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Conserved domains on  [gi|893567414|ref|NP_001297599|]
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zinc finger protein 111 isoform 2 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
9-58 6.16e-20

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.80  E-value: 6.16e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 893567414     9 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNLLAVGGQSPNKMEI 58
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLI 50
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
347-642 2.77e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 2.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 347 KPYKCEECGKGFTSASSFQRHQRVHTGEKPFVCSV--CGKGFSRTSYLQTHQRVHSGDKPY-QCDSCGKGFTQLSHLQAH 423
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 424 ERIHTDQKPYKCGDCGK------------RFSCSSNLHTHQRVHTGEKPYKCE----------ECGKGFSLVSGLQAHQR 481
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLppssrdpqlpdlLSISNLRNNPLPGNNSSSVNTPQSnslhpplpanSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 482 VETGKKPFKCNACQKRFSQAWNLHAHQRVHTGEKPYKCDTCGKAFGQRSGLQIHQRIHTGEKPFKCEECGKEFSLNSGLI 561
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 562 AHRRVHTGE-------KPYECKDCGKGFSLASSLRTHQR--VHTGE--KPFQCNE--CQKRFSQVSHLQSHQRVHTGEKP 628
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330
                 ....*....|....*.
gi 893567414 629 YKC--DRCGKAFSQKS 642
Cdd:COG5048  352 AKEklLNSSSKFSPLL 367
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
118-395 2.22e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 2.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 118 PRDSEDSSSPDLTNDHSSITENQEFLSGRAQGSwgkrrlRKRQNHQKNCLQTlmkNKPQLLAQHSPVHSTQEDTRHSFSV 197
Cdd:COG5048  207 SSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKS------LLSQSPSSLSSSD---SSSSASESPRSSLPTASSQSSSPNE 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 198 PVQESIYPGRKRYRCQECGKAFRQSSALQTHQRvhtgekpyrgnsrgknfSRSSDLNIHRQVHTREKPytckvCKKRFMQ 277
Cdd:COG5048  278 SDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLR-----------------SVNHSGESLKPFSCPYSL-----CGKLFSR 335

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 278 CSLLQAHKRIHTGEKPYKC--GDCGKRFSCISNFHIHQRVHTKSKPSK-----CDYG---KPFNLRCNFHSHQRVHTGEK 347
Cdd:COG5048  336 NDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKDLKNdkkseTLSNsciRNFKRDSNLSLHIITHLSFR 415

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 893567414 348 P--YKCEECGKGFTSASSFQRHQRVHTGEKPFVCSVCGKgFSRTSYLQTH 395
Cdd:COG5048  416 PynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
644-666 5.74e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.74e-04
                          10        20
                  ....*....|....*....|...
gi 893567414  644 LQVHKRIHTGEKPFKCEECGKEF 666
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
9-58 6.16e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.80  E-value: 6.16e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 893567414     9 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNLLAVGGQSPNKMEI 58
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLI 50
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 9-49 2.56e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.36  E-value: 2.56e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 893567414    9 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNLLAVG 49
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 9-45 7.23e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 68.73  E-value: 7.23e-15
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 893567414   9 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNL 45
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
347-642 2.77e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 2.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 347 KPYKCEECGKGFTSASSFQRHQRVHTGEKPFVCSV--CGKGFSRTSYLQTHQRVHSGDKPY-QCDSCGKGFTQLSHLQAH 423
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 424 ERIHTDQKPYKCGDCGK------------RFSCSSNLHTHQRVHTGEKPYKCE----------ECGKGFSLVSGLQAHQR 481
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLppssrdpqlpdlLSISNLRNNPLPGNNSSSVNTPQSnslhpplpanSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 482 VETGKKPFKCNACQKRFSQAWNLHAHQRVHTGEKPYKCDTCGKAFGQRSGLQIHQRIHTGEKPFKCEECGKEFSLNSGLI 561
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 562 AHRRVHTGE-------KPYECKDCGKGFSLASSLRTHQR--VHTGE--KPFQCNE--CQKRFSQVSHLQSHQRVHTGEKP 628
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330
                 ....*....|....*.
gi 893567414 629 YKC--DRCGKAFSQKS 642
Cdd:COG5048  352 AKEklLNSSSKFSPLL 367
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
118-395 2.22e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 2.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 118 PRDSEDSSSPDLTNDHSSITENQEFLSGRAQGSwgkrrlRKRQNHQKNCLQTlmkNKPQLLAQHSPVHSTQEDTRHSFSV 197
Cdd:COG5048  207 SSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKS------LLSQSPSSLSSSD---SSSSASESPRSSLPTASSQSSSPNE 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 198 PVQESIYPGRKRYRCQECGKAFRQSSALQTHQRvhtgekpyrgnsrgknfSRSSDLNIHRQVHTREKPytckvCKKRFMQ 277
Cdd:COG5048  278 SDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLR-----------------SVNHSGESLKPFSCPYSL-----CGKLFSR 335

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 278 CSLLQAHKRIHTGEKPYKC--GDCGKRFSCISNFHIHQRVHTKSKPSK-----CDYG---KPFNLRCNFHSHQRVHTGEK 347
Cdd:COG5048  336 NDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKDLKNdkkseTLSNsciRNFKRDSNLSLHIITHLSFR 415

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 893567414 348 P--YKCEECGKGFTSASSFQRHQRVHTGEKPFVCSVCGKgFSRTSYLQTH 395
Cdd:COG5048  416 PynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
615-640 2.91e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.91e-04
                          10        20
                  ....*....|....*....|....*.
gi 893567414  615 HLQSHQRVHTGEKPYKCDRCGKAFSQ 640
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
644-666 5.74e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.74e-04
                          10        20
                  ....*....|....*....|...
gi 893567414  644 LQVHKRIHTGEKPFKCEECGKEF 666
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 599-647 5.98e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 5.98e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 893567414 599 KPFqCNECQKRFSQVSHLQSHQRvhtgEKPYKCDRCGKAFSQKSGLQVH 647
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-305 7.93e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.93e-04
                          10        20
                  ....*....|....*....|....*
gi 893567414  281 LQAHKRIHTGEKPYKCGDCGKRFSC 305
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 625-677 9.72e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 9.72e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 893567414 625 GEKPYKCD--RCGKAFSQKSGLQVHKR-------------------IHTGEKPFKCEECGKEFIWSSGLSAHRK 677
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
9-58 6.16e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.80  E-value: 6.16e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 893567414     9 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNLLAVGGQSPNKMEI 58
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLI 50
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 9-49 2.56e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.36  E-value: 2.56e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 893567414    9 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNLLAVG 49
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 9-45 7.23e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 68.73  E-value: 7.23e-15
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 893567414   9 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNL 45
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
347-642 2.77e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 2.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 347 KPYKCEECGKGFTSASSFQRHQRVHTGEKPFVCSV--CGKGFSRTSYLQTHQRVHSGDKPY-QCDSCGKGFTQLSHLQAH 423
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 424 ERIHTDQKPYKCGDCGK------------RFSCSSNLHTHQRVHTGEKPYKCE----------ECGKGFSLVSGLQAHQR 481
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLppssrdpqlpdlLSISNLRNNPLPGNNSSSVNTPQSnslhpplpanSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 482 VETGKKPFKCNACQKRFSQAWNLHAHQRVHTGEKPYKCDTCGKAFGQRSGLQIHQRIHTGEKPFKCEECGKEFSLNSGLI 561
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 562 AHRRVHTGE-------KPYECKDCGKGFSLASSLRTHQR--VHTGE--KPFQCNE--CQKRFSQVSHLQSHQRVHTGEKP 628
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330
                 ....*....|....*.
gi 893567414 629 YKC--DRCGKAFSQKS 642
Cdd:COG5048  352 AKEklLNSSSKFSPLL 367
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
210-619 6.30e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.10  E-value: 6.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 210 YRCQECGKAFRQSSALQTHQRVHTGEKPY--RGNSRGKNFSRSSDLNIHRQVHTREKPYTCKvckkrfmQCSLLQAHKRI 287
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSqcSYSGCDKSFSRPLELSRHLRTHHNNPSDLNS-------KSLPLSNSKAS 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 288 HTGEKPYKCGDCGKRFSCISNFHIHQRVHTKSKP-SKCDYGKPFNLRCN------------------------------F 336
Cdd:COG5048  107 SSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLlSISNLRNNPLPGNNsssvntpqsnslhpplpanslskdpssnlsL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 337 HSHQRVHTGEKPYKCEECGKGFTSASSFQRHQRVHTGEKPFVCSVCGKGFSRTSYLQTHQRVHSGDKPYQCDSCGKGFTQ 416
Cdd:COG5048  187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLP 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 417 LSHLQAHERIHTD-------QKPYKCGDCGKRFSCSSNLHTHQR--VHTGE--KPYKCEE--CGKGFSLVSGLQAHQRVE 483
Cdd:COG5048  267 TASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLH 346

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 484 TGKKPFKCNACQkrfsqawnlhaHQRVHTGEKPYKcdtcgkafgqRSGLQIHQRIHTGEKPFKCE--ECGKEFSLNSGLI 561
Cdd:COG5048  347 TSISPAKEKLLN-----------SSSKFSPLLNNE----------PPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLS 405

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 562 AHRRVHTGEKPYECKD--CGKGFSLASSLRTHQRVHTGEKPFQCNeCQKRFSQVSHLQSH 619
Cdd:COG5048  406 LHIITHLSFRPYNCKNppCSKSFNRHYNLIPHKKIHTNHAPLLCS-ILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
402-685 3.54e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 3.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 402 DKPYQCDSCGKGFTQLSHLQAHERIHTDQKPYKCGD--CGKRFSCSSNLHTHQRVHTGEKPYKCE--------------- 464
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssl 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 465 -ECGKGFSLVSGLQAHQRVETGKKPFKCNACQKRFSQ-----------------AWNLHAHQRVHTGEKPYKCDTCG--- 523
Cdd:COG5048  111 sSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRnnplpgnnsssvntpqsNSLHPPLPANSLSKDPSSNLSLLiss 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 524 -KAFGQRSGLQIHQRIHTGEKPFKCEECGKEFSlNSGLIAHRRVHTGEKPYECkdcgkgfSLASSLRTHQRVHTGEKPFQ 602
Cdd:COG5048  191 nVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLS-------QSPSSLSSSDSSSSASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 603 CNECQKRFSQVSHLQSHQRVHTG-EKPYKCDRCGKAFSQKSGLQVHKR--IHTGE--KPFKCEE--CGKEFIWSSGLSAH 675
Cdd:COG5048  263 SSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330
                 ....*....|
gi 893567414 676 RKVHTGEKPY 685
Cdd:COG5048  343 ILLHTSISPA 352
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
118-395 2.22e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 2.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 118 PRDSEDSSSPDLTNDHSSITENQEFLSGRAQGSwgkrrlRKRQNHQKNCLQTlmkNKPQLLAQHSPVHSTQEDTRHSFSV 197
Cdd:COG5048  207 SSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKS------LLSQSPSSLSSSD---SSSSASESPRSSLPTASSQSSSPNE 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 198 PVQESIYPGRKRYRCQECGKAFRQSSALQTHQRvhtgekpyrgnsrgknfSRSSDLNIHRQVHTREKPytckvCKKRFMQ 277
Cdd:COG5048  278 SDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLR-----------------SVNHSGESLKPFSCPYSL-----CGKLFSR 335

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 278 CSLLQAHKRIHTGEKPYKC--GDCGKRFSCISNFHIHQRVHTKSKPSK-----CDYG---KPFNLRCNFHSHQRVHTGEK 347
Cdd:COG5048  336 NDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKDLKNdkkseTLSNsciRNFKRDSNLSLHIITHLSFR 415

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 893567414 348 P--YKCEECGKGFTSASSFQRHQRVHTGEKPFVCSVCGKgFSRTSYLQTH 395
Cdd:COG5048  416 PynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
615-640 2.91e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.91e-04
                          10        20
                  ....*....|....*....|....*.
gi 893567414  615 HLQSHQRVHTGEKPYKCDRCGKAFSQ 640
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
644-666 5.74e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.74e-04
                          10        20
                  ....*....|....*....|...
gi 893567414  644 LQVHKRIHTGEKPFKCEECGKEF 666
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 599-647 5.98e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 5.98e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 893567414 599 KPFqCNECQKRFSQVSHLQSHQRvhtgEKPYKCDRCGKAFSQKSGLQVH 647
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVH 44
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 571-623 7.21e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 7.21e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 893567414 571 KPYeCKDCGKGFSLASSLRTHQRvhtgEKPFQCNECQKRFSQVSHLQSH-QRVH 623
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
587-612 7.93e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.93e-04
                          10        20
                  ....*....|....*....|....*.
gi 893567414  587 SLRTHQRVHTGEKPFQCNECQKRFSQ 612
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-305 7.93e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.93e-04
                          10        20
                  ....*....|....*....|....*
gi 893567414  281 LQAHKRIHTGEKPYKCGDCGKRFSC 305
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
532-555 9.28e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.28e-04
                          10        20
                  ....*....|....*....|....
gi 893567414  532 LQIHQRIHTGEKPFKCEECGKEFS 555
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 625-677 9.72e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 9.72e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 893567414 625 GEKPYKCD--RCGKAFSQKSGLQVHKR-------------------IHTGEKPFKCEECGKEFIWSSGLSAHRK 677
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 513-564 1.04e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.04e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 893567414 513 GEKPYKCDT--CGKAFGQRSGLQIH-------------------QRIHTGEKPFKCEECGKEFSLNSGLIAHR 564
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHmlhghqnqklhenpspekmNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 457-535 1.39e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 457 GEKPYKCE--ECGKGFSLVSGLQAHQrvetgkkpfKCNACQKRFSQAWNLHAHQRVHTGEKPYKCDTCGKAFGQRSGLQI 534
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 893567414 535 H 535
Cdd:COG5189  417 H 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 345-429 1.56e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 345 GEKPYKCE--ECGKGFTSASSFQRHqRVHtgekpfvcSVCGKGFSRTSYLQTHQRVHSGDKPYQCDSCGKGFTQLSHLQA 422
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*..
gi 893567414 423 HERIHTD 429
Cdd:COG5189  417 HRKHSHD 423
zf-H2C2_2 pfam13465
Zinc-finger double domain;
363-388 2.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.06e-03
                          10        20
                  ....*....|....*....|....*.
gi 893567414  363 SFQRHQRVHTGEKPFVCSVCGKGFSR 388
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 515-567 2.31e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.54  E-value: 2.31e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 893567414 515 KPYkCDTCGKAFGQRSGLQIHQRIHTgekpFKCEECGKEFSLNSGLIAH-RRVH 567
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
391-416 2.68e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.68e-03
                          10        20
                  ....*....|....*....|....*.
gi 893567414  391 YLQTHQRVHSGDKPYQCDSCGKGFTQ 416
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 562-648 3.32e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 3.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 562 AHRRVHTGEKPYECK--DCGKGFSLASSLRTHqRVHtgekpfqcNECQKRFSQVSHLQSHQRVHTGEKPYKCDRCGKAFS 639
Cdd:COG5189  339 SRMLKVKDGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYK 409


                 ....*....
gi 893567414 640 QKSGLQVHK 648
Cdd:COG5189  410 NLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 401-479 3.44e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 3.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 401 GDKPYQCD--SCGKGFTQLSHLQAHeRIHtdqkpykcGDCGKRFSCSSNLHTHQRVHTGEKPYKCEECGKGFSLVSGLQA 478
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 893567414 479 H 479
Cdd:COG5189  417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
338-360 3.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.78e-03
                          10        20
                  ....*....|....*....|...
gi 893567414  338 SHQRVHTGEKPYKCEECGKGFTS 360
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
419-444 3.93e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.93e-03
                          10        20
                  ....*....|....*....|....*.
gi 893567414  419 HLQAHERIHTDQKPYKCGDCGKRFSC 444
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
429-680 6.37e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 6.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 429 DQKPYKCGDCGKRFSCSSNLHTHQRVHTGEKPYKC--EECGKGFSLVSGLQAHQRVETGKKPFKCNAC-----QKRFSQA 501
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSlplsnSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 502 WNLHAHQRVhtgeKPYKCDTCGKAFGQRSGLQIHQRIHTGEKPFKCEECGKEF-----SLNSGLIAHRRVHTGEKPYEck 576
Cdd:COG5048  110 LSSSSSNSN----DNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqSNSLHPPLPANSLSKDPSSN-- 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567414 577 dcgkgfslaSSLRTHQRVHTGEKPFQCNECQKRFSQVSHLQSHQRVHTGEKPYKCDRCGKAFSQKSGLQVHKRIHTGEKP 656
Cdd:COG5048  184 ---------LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS 254

                        250       260
                 ....*....|....*....|....
gi 893567414 657 FKCEECGKEFIWSSGLSAHRKVHT 680
Cdd:COG5048  255 SSASESPRSSLPTASSQSSSPNES 278
zf-H2C2_2 pfam13465
Zinc-finger double domain;
507-526 6.95e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.95e-03
                          10        20
                  ....*....|....*....|
gi 893567414  507 HQRVHTGEKPYKCDTCGKAF 526
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 349-371 7.05e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 7.05e-03
                          10        20
                  ....*....|....*....|...
gi 893567414  349 YKCEECGKGFTSASSFQRHQRVH 371
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 210-232 7.63e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.63e-03
                          10        20
                  ....*....|....*....|...
gi 893567414  210 YRCQECGKAFRQSSALQTHQRVH 232
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
447-471 8.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.14e-03
                          10        20
                  ....*....|....*....|....*
gi 893567414  447 NLHTHQRVHTGEKPYKCEECGKGFS 471
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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