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Conserved domains on  [gi|922580996|ref|NP_001300068|]
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Galectin [Caenorhabditis elegans]

Protein Classification

GLECT domain-containing protein( domain architecture ID 10209291)

GLECT domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 69-198 8.36e-20

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


:

Pssm-ID: 214904  Cd Length: 122  Bit Score: 80.71  E-value: 8.36e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580996    69 PGGFVSPQSARFTITPFLSSERFTINLKSK--GEFLFHFRVDMPNQaqkikpHVIRNSSKNGvKWLTEERTfGTFPFHKG 146
Cdd:smart00908   1 PGGLSPGSSITIRGIVLPDAKRFSINLQCGpnADIALHFNPRFDEG------TIVRNSKQNG-KWGKEERS-GGFPFQPG 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 922580996   147 ITHDIVFTAYGKSVTVDVDGAPFVKFVYRDGddPVNVDQITVVGDVLIHRFE 198
Cdd:smart00908  73 QPFELEILVEEDEFKVAVNGQHFLEFPHRLP--LESIDTLEISGDVQLTSVQ 122
GLECT super family cl00071
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 2-30 9.62e-05

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


The actual alignment was detected with superfamily member smart00276:

Pssm-ID: 469601  Cd Length: 128  Bit Score: 40.67  E-value: 9.62e-05
                           10        20
                   ....*....|....*....|....*....
gi 922580996     2 CDFPHRVPVESIRTISINGNIRVDYVEFH 30
Cdd:smart00276 100 TTFPHRLPLESIDYLSINGDVQLTSVSFE 128
 
Name Accession Description Interval E-value
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 69-198 8.36e-20

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 80.71  E-value: 8.36e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580996    69 PGGFVSPQSARFTITPFLSSERFTINLKSK--GEFLFHFRVDMPNQaqkikpHVIRNSSKNGvKWLTEERTfGTFPFHKG 146
Cdd:smart00908   1 PGGLSPGSSITIRGIVLPDAKRFSINLQCGpnADIALHFNPRFDEG------TIVRNSKQNG-KWGKEERS-GGFPFQPG 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 922580996   147 ITHDIVFTAYGKSVTVDVDGAPFVKFVYRDGddPVNVDQITVVGDVLIHRFE 198
Cdd:smart00908  73 QPFELEILVEEDEFKVAVNGQHFLEFPHRLP--LESIDTLEISGDVQLTSVQ 122
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 62-198 5.35e-17

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 73.44  E-value: 5.35e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580996  62 PFELPLPpGGFVSPQSARFTITPFLSSERFTINL-KSKGEFLFHFRVDMPNqaqkikPHVIRNSSKNGvKWLTEERtFGT 140
Cdd:cd00070    1 PYKLPLP-GGLKPGSTLTVKGRVLPNAKRFSINLgTGSSDIALHFNPRFDE------NVIVRNSFLNG-NWGPEER-SGG 71

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 922580996 141 FPFHKGITHDIVFTAYGKSVTVDVDGAPFVKFVYRDGddPVNVDQITVVGDVLIHRFE 198
Cdd:cd00070   72 FPFQPGQPFELTILVEEDKFQIFVNGQHFFSFPHRLP--LESIDYLSINGDVSLTSVE 127
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 69-198 1.14e-12

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 61.89  E-value: 1.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580996   69 PGGFVSPQSARFTITPFLSSERFTINLKSKGEF----LFHFRVDMPnqaqkiKPHVIRNSSKNGvKWLTEERTfGTFPFH 144
Cdd:pfam00337   1 PGGLQPGSSLTIKGIVLPDAQRFSINLQTGVGPsddiALHFNPRFD------ENVIVRNSRQNG-QWGQEERE-GGFPFQ 72

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 922580996  145 KGITHDIVFTAYGKSVTVDVDGAPFVKFVYRDGddPVNVDQITVVGDVLIHRFE 198
Cdd:pfam00337  73 PGQPFELTILVGDDHFKIYVNGQHFTTFKHRLP--PEDIDALQVRGDVKLTSVL 124
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
 2-30 9.62e-05

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 40.67  E-value: 9.62e-05
                           10        20
                   ....*....|....*....|....*....
gi 922580996     2 CDFPHRVPVESIRTISINGNIRVDYVEFH 30
Cdd:smart00276 100 TTFPHRLPLESIDYLSINGDVQLTSVSFE 128
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 1-28 2.09e-04

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 39.54  E-value: 2.09e-04
                         10        20
                 ....*....|....*....|....*...
gi 922580996   1 MCDFPHRVPVESIRTISINGNIRVDYVE 28
Cdd:cd00070  100 FFSFPHRLPLESIDYLSINGDVSLTSVE 127
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 2-28 3.13e-03

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 36.08  E-value: 3.13e-03
                          10        20
                  ....*....|....*....|....*..
gi 922580996    2 CDFPHRVPVESIRTISINGNIRVDYVE 28
Cdd:pfam00337  98 TTFKHRLPPEDIDALQVRGDVKLTSVL 124
 
Name Accession Description Interval E-value
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 69-198 8.36e-20

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 80.71  E-value: 8.36e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580996    69 PGGFVSPQSARFTITPFLSSERFTINLKSK--GEFLFHFRVDMPNQaqkikpHVIRNSSKNGvKWLTEERTfGTFPFHKG 146
Cdd:smart00908   1 PGGLSPGSSITIRGIVLPDAKRFSINLQCGpnADIALHFNPRFDEG------TIVRNSKQNG-KWGKEERS-GGFPFQPG 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 922580996   147 ITHDIVFTAYGKSVTVDVDGAPFVKFVYRDGddPVNVDQITVVGDVLIHRFE 198
Cdd:smart00908  73 QPFELEILVEEDEFKVAVNGQHFLEFPHRLP--LESIDTLEISGDVQLTSVQ 122
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 62-198 5.35e-17

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 73.44  E-value: 5.35e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580996  62 PFELPLPpGGFVSPQSARFTITPFLSSERFTINL-KSKGEFLFHFRVDMPNqaqkikPHVIRNSSKNGvKWLTEERtFGT 140
Cdd:cd00070    1 PYKLPLP-GGLKPGSTLTVKGRVLPNAKRFSINLgTGSSDIALHFNPRFDE------NVIVRNSFLNG-NWGPEER-SGG 71

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 922580996 141 FPFHKGITHDIVFTAYGKSVTVDVDGAPFVKFVYRDGddPVNVDQITVVGDVLIHRFE 198
Cdd:cd00070   72 FPFQPGQPFELTILVEEDKFQIFVNGQHFFSFPHRLP--LESIDYLSINGDVSLTSVE 127
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
 63-198 1.34e-14

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 67.25  E-value: 1.34e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580996    63 FELPLPpGGFVSPQSARFTITPFLSSERFTINL-KSKGEFLFHFRVDmPNqaqkiKPHVIRNSSKNGVkWLTEERTfGTF 141
Cdd:smart00276   1 FTLPIP-GGLKPGQTLTVRGIVLPDAKRFSINLlTGGDDIALHFNPR-FN-----ENKIVCNSKLNGS-WGSEERE-GGF 71

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 922580996   142 PFHKGITHDIVFTAYGKSVTVDVDGAPFVKFVYRDGddPVNVDQITVVGDVLIHRFE 198
Cdd:smart00276  72 PFQPGQPFDLTIIVQPDHFQIFVNGVHITTFPHRLP--LESIDYLSINGDVQLTSVS 126
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 69-198 1.14e-12

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 61.89  E-value: 1.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580996   69 PGGFVSPQSARFTITPFLSSERFTINLKSKGEF----LFHFRVDMPnqaqkiKPHVIRNSSKNGvKWLTEERTfGTFPFH 144
Cdd:pfam00337   1 PGGLQPGSSLTIKGIVLPDAQRFSINLQTGVGPsddiALHFNPRFD------ENVIVRNSRQNG-QWGQEERE-GGFPFQ 72

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 922580996  145 KGITHDIVFTAYGKSVTVDVDGAPFVKFVYRDGddPVNVDQITVVGDVLIHRFE 198
Cdd:pfam00337  73 PGQPFELTILVGDDHFKIYVNGQHFTTFKHRLP--PEDIDALQVRGDVKLTSVL 124
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
 2-30 9.62e-05

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 40.67  E-value: 9.62e-05
                           10        20
                   ....*....|....*....|....*....
gi 922580996     2 CDFPHRVPVESIRTISINGNIRVDYVEFH 30
Cdd:smart00276 100 TTFPHRLPLESIDYLSINGDVQLTSVSFE 128
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 2-28 1.36e-04

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 39.88  E-value: 1.36e-04
                           10        20
                   ....*....|....*....|....*..
gi 922580996     2 CDFPHRVPVESIRTISINGNIRVDYVE 28
Cdd:smart00908  96 LEFPHRLPLESIDTLEISGDVQLTSVQ 122
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 1-28 2.09e-04

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 39.54  E-value: 2.09e-04
                         10        20
                 ....*....|....*....|....*...
gi 922580996   1 MCDFPHRVPVESIRTISINGNIRVDYVE 28
Cdd:cd00070  100 FFSFPHRLPLESIDYLSINGDVSLTSVE 127
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 2-28 3.13e-03

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 36.08  E-value: 3.13e-03
                          10        20
                  ....*....|....*....|....*..
gi 922580996    2 CDFPHRVPVESIRTISINGNIRVDYVE 28
Cdd:pfam00337  98 TTFKHRLPPEDIDALQVRGDVKLTSVL 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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