NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|922581394|ref|NP_001300267|]
View 

PAW domain-containing protein [Caenorhabditis elegans]

Protein Classification

PAW domain-containing protein( domain architecture ID 10652287)

PAW domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PAW smart00613
domain present in PNGases and other hypothetical proteins; present in several copies in ...
 83-170 1.32e-34

domain present in PNGases and other hypothetical proteins; present in several copies in proteins with unknown function in C. elegans


:

Pssm-ID: 214745  Cd Length: 89  Bit Score: 126.61  E-value: 1.32e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581394    83 RFKNRYFEFKYEIVRGNYSHTNEDELAVKPFIVRNIERHSDGEPYDVYLHKIKPDEEGM-IYWKFNLKATDKVVKTLVIR 161
Cdd:smart00613   1 ESGENYVKFTYDIINDTYSHTNEDGSPVQPYEVKNIERVVDKELNEVYLHKKRPEEEGNyIYWKFDLKSTGKSVEKVVIR 80


                   ....*....
gi 922581394   162 MIGINQTLN 170
Cdd:smart00613  81 MSGIEEIAN 89
PAW smart00613
domain present in PNGases and other hypothetical proteins; present in several copies in ...
 449-536 1.56e-34

domain present in PNGases and other hypothetical proteins; present in several copies in proteins with unknown function in C. elegans


:

Pssm-ID: 214745  Cd Length: 89  Bit Score: 126.61  E-value: 1.56e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581394   449 RFKNRYFEFKYEIERGKYSHTNEDESAVKPFLVKNIERHADDDTYDVYLQKIKPDEEGM-IYWKFDLKATDKVVKTLVIR 527
Cdd:smart00613   1 ESGENYVKFTYDIINDTYSHTNEDGSPVQPYEVKNIERVVDKELNEVYLHKKRPEEEGNyIYWKFDLKSTGKSVEKVVIR 80


                   ....*....
gi 922581394   528 MIGINQTLN 536
Cdd:smart00613  81 MSGIEEIAN 89
PAW smart00613
domain present in PNGases and other hypothetical proteins; present in several copies in ...
 266-353 3.20e-33

domain present in PNGases and other hypothetical proteins; present in several copies in proteins with unknown function in C. elegans


:

Pssm-ID: 214745  Cd Length: 89  Bit Score: 122.76  E-value: 3.20e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581394   266 KTGENYAKFTYNFLNNSYSHNEPDGSPVRLFDFNGLERVEDYTENTVFLRRKNPKEKGN-IKWALDLNIDGLSVETVVIK 344
Cdd:smart00613   1 ESGENYVKFTYDIINDTYSHTNEDGSPVQPYEVKNIERVVDKELNEVYLHKKRPEEEGNyIYWKFDLKSTGKSVEKVVIR 80


                   ....*....
gi 922581394   345 IIGIDEIDN 353
Cdd:smart00613  81 MSGIEEIAN 89
PAW smart00613
domain present in PNGases and other hypothetical proteins; present in several copies in ...
 632-706 5.58e-26

domain present in PNGases and other hypothetical proteins; present in several copies in proteins with unknown function in C. elegans


:

Pssm-ID: 214745  Cd Length: 89  Bit Score: 101.96  E-value: 5.58e-26
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 922581394   632 KTGENYAKFTYNFINNLYSHTEPDGSPVRLFDFNGLERVEDYTENTVFLRRKNPKEKGN-IRWALNLRIDGKYVEK 706
Cdd:smart00613   1 ESGENYVKFTYDIINDTYSHTNEDGSPVQPYEVKNIERVVDKELNEVYLHKKRPEEEGNyIYWKFDLKSTGKSVEK 76
 
Name Accession Description Interval E-value
PAW smart00613
domain present in PNGases and other hypothetical proteins; present in several copies in ...
 83-170 1.32e-34

domain present in PNGases and other hypothetical proteins; present in several copies in proteins with unknown function in C. elegans


Pssm-ID: 214745  Cd Length: 89  Bit Score: 126.61  E-value: 1.32e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581394    83 RFKNRYFEFKYEIVRGNYSHTNEDELAVKPFIVRNIERHSDGEPYDVYLHKIKPDEEGM-IYWKFNLKATDKVVKTLVIR 161
Cdd:smart00613   1 ESGENYVKFTYDIINDTYSHTNEDGSPVQPYEVKNIERVVDKELNEVYLHKKRPEEEGNyIYWKFDLKSTGKSVEKVVIR 80


                   ....*....
gi 922581394   162 MIGINQTLN 170
Cdd:smart00613  81 MSGIEEIAN 89
PAW smart00613
domain present in PNGases and other hypothetical proteins; present in several copies in ...
 449-536 1.56e-34

domain present in PNGases and other hypothetical proteins; present in several copies in proteins with unknown function in C. elegans


Pssm-ID: 214745  Cd Length: 89  Bit Score: 126.61  E-value: 1.56e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581394   449 RFKNRYFEFKYEIERGKYSHTNEDESAVKPFLVKNIERHADDDTYDVYLQKIKPDEEGM-IYWKFDLKATDKVVKTLVIR 527
Cdd:smart00613   1 ESGENYVKFTYDIINDTYSHTNEDGSPVQPYEVKNIERVVDKELNEVYLHKKRPEEEGNyIYWKFDLKSTGKSVEKVVIR 80


                   ....*....
gi 922581394   528 MIGINQTLN 536
Cdd:smart00613  81 MSGIEEIAN 89
PAW smart00613
domain present in PNGases and other hypothetical proteins; present in several copies in ...
 266-353 3.20e-33

domain present in PNGases and other hypothetical proteins; present in several copies in proteins with unknown function in C. elegans


Pssm-ID: 214745  Cd Length: 89  Bit Score: 122.76  E-value: 3.20e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581394   266 KTGENYAKFTYNFLNNSYSHNEPDGSPVRLFDFNGLERVEDYTENTVFLRRKNPKEKGN-IKWALDLNIDGLSVETVVIK 344
Cdd:smart00613   1 ESGENYVKFTYDIINDTYSHTNEDGSPVQPYEVKNIERVVDKELNEVYLHKKRPEEEGNyIYWKFDLKSTGKSVEKVVIR 80


                   ....*....
gi 922581394   345 IIGIDEIDN 353
Cdd:smart00613  81 MSGIEEIAN 89
PAW smart00613
domain present in PNGases and other hypothetical proteins; present in several copies in ...
 632-706 5.58e-26

domain present in PNGases and other hypothetical proteins; present in several copies in proteins with unknown function in C. elegans


Pssm-ID: 214745  Cd Length: 89  Bit Score: 101.96  E-value: 5.58e-26
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 922581394   632 KTGENYAKFTYNFINNLYSHTEPDGSPVRLFDFNGLERVEDYTENTVFLRRKNPKEKGN-IRWALNLRIDGKYVEK 706
Cdd:smart00613   1 ESGENYVKFTYDIINDTYSHTNEDGSPVQPYEVKNIERVVDKELNEVYLHKKRPEEEGNyIYWKFDLKSTGKSVEK 76
PAW pfam04721
PNGase C-terminal domain, mannose-binding module PAW; The PAW domain is found at the ...
 451-561 2.31e-06

PNGase C-terminal domain, mannose-binding module PAW; The PAW domain is found at the C-terminus of PGNase, or peptide-N-glycanase, enzymes. It was named for 'domain present in PNGases and other worm proteins'. PNGase catalyzes the deglycosylation of several misfolded N-linked glycoproteins by cleaving off the bulky glycan chain before these proteins are degraded by the proteasome. PNGase specifically acts on the unfolded form of high-mannose type N-glycosylated proteins, and this domain appears to be the mannose-binding domain, which contributes to the oligosaccharide-binding specificity of PNGase.


Pssm-ID: 461409  Cd Length: 197  Bit Score: 48.82  E-value: 2.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581394  451 KNRYFEFKYEIERGKYSHTNED-------ESAVkpFLVKNIERHADDDTYDVYLQKIKPDEEGMIYWKFDLKATDKVVKT 523
Cdd:pfam04721  35 KAKLFHLRYSIVKDIYTRVSNNnetikgwESGV--FSSENIFRKVEHDWKMVYLARTEGTSSGSISWKFDLSSSGLKIKS 112

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 922581394  524 LVIRmigINQTLNGGGKAEACLETFENCTEIPVDEDLI 561
Cdd:pfam04721 113 ISLK---ASSQTFESGKVSWRLQSDKTTVEIPGDKTLQ 147
PAW pfam04721
PNGase C-terminal domain, mannose-binding module PAW; The PAW domain is found at the ...
 85-191 2.41e-04

PNGase C-terminal domain, mannose-binding module PAW; The PAW domain is found at the C-terminus of PGNase, or peptide-N-glycanase, enzymes. It was named for 'domain present in PNGases and other worm proteins'. PNGase catalyzes the deglycosylation of several misfolded N-linked glycoproteins by cleaving off the bulky glycan chain before these proteins are degraded by the proteasome. PNGase specifically acts on the unfolded form of high-mannose type N-glycosylated proteins, and this domain appears to be the mannose-binding domain, which contributes to the oligosaccharide-binding specificity of PNGase.


Pssm-ID: 461409  Cd Length: 197  Bit Score: 43.04  E-value: 2.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581394   85 KNRYFEFKYEIVRGNYSHTNEDELAVKPFI-----VRNIERHsdgEPYD---VYLHKIKPDEEGMIYWKFNLKATDKVVK 156
Cdd:pfam04721  35 KAKLFHLRYSIVKDIYTRVSNNNETIKGWEsgvfsSENIFRK---VEHDwkmVYLARTEGTSSGSISWKFDLSSSGLKIK 111

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 922581394  157 TLVIRmigINQTLNEGGKAEACLETFENCLEAPAN 191
Cdd:pfam04721 112 SISLK---ASSQTFESGKVSWRLQSDKTTVEIPGD 143
 
Name Accession Description Interval E-value
PAW smart00613
domain present in PNGases and other hypothetical proteins; present in several copies in ...
 83-170 1.32e-34

domain present in PNGases and other hypothetical proteins; present in several copies in proteins with unknown function in C. elegans


Pssm-ID: 214745  Cd Length: 89  Bit Score: 126.61  E-value: 1.32e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581394    83 RFKNRYFEFKYEIVRGNYSHTNEDELAVKPFIVRNIERHSDGEPYDVYLHKIKPDEEGM-IYWKFNLKATDKVVKTLVIR 161
Cdd:smart00613   1 ESGENYVKFTYDIINDTYSHTNEDGSPVQPYEVKNIERVVDKELNEVYLHKKRPEEEGNyIYWKFDLKSTGKSVEKVVIR 80


                   ....*....
gi 922581394   162 MIGINQTLN 170
Cdd:smart00613  81 MSGIEEIAN 89
PAW smart00613
domain present in PNGases and other hypothetical proteins; present in several copies in ...
 449-536 1.56e-34

domain present in PNGases and other hypothetical proteins; present in several copies in proteins with unknown function in C. elegans


Pssm-ID: 214745  Cd Length: 89  Bit Score: 126.61  E-value: 1.56e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581394   449 RFKNRYFEFKYEIERGKYSHTNEDESAVKPFLVKNIERHADDDTYDVYLQKIKPDEEGM-IYWKFDLKATDKVVKTLVIR 527
Cdd:smart00613   1 ESGENYVKFTYDIINDTYSHTNEDGSPVQPYEVKNIERVVDKELNEVYLHKKRPEEEGNyIYWKFDLKSTGKSVEKVVIR 80


                   ....*....
gi 922581394   528 MIGINQTLN 536
Cdd:smart00613  81 MSGIEEIAN 89
PAW smart00613
domain present in PNGases and other hypothetical proteins; present in several copies in ...
 266-353 3.20e-33

domain present in PNGases and other hypothetical proteins; present in several copies in proteins with unknown function in C. elegans


Pssm-ID: 214745  Cd Length: 89  Bit Score: 122.76  E-value: 3.20e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581394   266 KTGENYAKFTYNFLNNSYSHNEPDGSPVRLFDFNGLERVEDYTENTVFLRRKNPKEKGN-IKWALDLNIDGLSVETVVIK 344
Cdd:smart00613   1 ESGENYVKFTYDIINDTYSHTNEDGSPVQPYEVKNIERVVDKELNEVYLHKKRPEEEGNyIYWKFDLKSTGKSVEKVVIR 80


                   ....*....
gi 922581394   345 IIGIDEIDN 353
Cdd:smart00613  81 MSGIEEIAN 89
PAW smart00613
domain present in PNGases and other hypothetical proteins; present in several copies in ...
 632-706 5.58e-26

domain present in PNGases and other hypothetical proteins; present in several copies in proteins with unknown function in C. elegans


Pssm-ID: 214745  Cd Length: 89  Bit Score: 101.96  E-value: 5.58e-26
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 922581394   632 KTGENYAKFTYNFINNLYSHTEPDGSPVRLFDFNGLERVEDYTENTVFLRRKNPKEKGN-IRWALNLRIDGKYVEK 706
Cdd:smart00613   1 ESGENYVKFTYDIINDTYSHTNEDGSPVQPYEVKNIERVVDKELNEVYLHKKRPEEEGNyIYWKFDLKSTGKSVEK 76
PAW pfam04721
PNGase C-terminal domain, mannose-binding module PAW; The PAW domain is found at the ...
 451-561 2.31e-06

PNGase C-terminal domain, mannose-binding module PAW; The PAW domain is found at the C-terminus of PGNase, or peptide-N-glycanase, enzymes. It was named for 'domain present in PNGases and other worm proteins'. PNGase catalyzes the deglycosylation of several misfolded N-linked glycoproteins by cleaving off the bulky glycan chain before these proteins are degraded by the proteasome. PNGase specifically acts on the unfolded form of high-mannose type N-glycosylated proteins, and this domain appears to be the mannose-binding domain, which contributes to the oligosaccharide-binding specificity of PNGase.


Pssm-ID: 461409  Cd Length: 197  Bit Score: 48.82  E-value: 2.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581394  451 KNRYFEFKYEIERGKYSHTNED-------ESAVkpFLVKNIERHADDDTYDVYLQKIKPDEEGMIYWKFDLKATDKVVKT 523
Cdd:pfam04721  35 KAKLFHLRYSIVKDIYTRVSNNnetikgwESGV--FSSENIFRKVEHDWKMVYLARTEGTSSGSISWKFDLSSSGLKIKS 112

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 922581394  524 LVIRmigINQTLNGGGKAEACLETFENCTEIPVDEDLI 561
Cdd:pfam04721 113 ISLK---ASSQTFESGKVSWRLQSDKTTVEIPGDKTLQ 147
PAW pfam04721
PNGase C-terminal domain, mannose-binding module PAW; The PAW domain is found at the ...
 85-191 2.41e-04

PNGase C-terminal domain, mannose-binding module PAW; The PAW domain is found at the C-terminus of PGNase, or peptide-N-glycanase, enzymes. It was named for 'domain present in PNGases and other worm proteins'. PNGase catalyzes the deglycosylation of several misfolded N-linked glycoproteins by cleaving off the bulky glycan chain before these proteins are degraded by the proteasome. PNGase specifically acts on the unfolded form of high-mannose type N-glycosylated proteins, and this domain appears to be the mannose-binding domain, which contributes to the oligosaccharide-binding specificity of PNGase.


Pssm-ID: 461409  Cd Length: 197  Bit Score: 43.04  E-value: 2.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581394   85 KNRYFEFKYEIVRGNYSHTNEDELAVKPFI-----VRNIERHsdgEPYD---VYLHKIKPDEEGMIYWKFNLKATDKVVK 156
Cdd:pfam04721  35 KAKLFHLRYSIVKDIYTRVSNNNETIKGWEsgvfsSENIFRK---VEHDwkmVYLARTEGTSSGSISWKFDLSSSGLKIK 111

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 922581394  157 TLVIRmigINQTLNEGGKAEACLETFENCLEAPAN 191
Cdd:pfam04721 112 SISLK---ASSQTFESGKVSWRLQSDKTTVEIPGD 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH