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Conserved domains on  [gi|939619905|ref|NP_001303370|]
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thoc6, isoform C [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12822048)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 115-265 1.24e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 64.28  E-value: 1.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619905 115 DVNSMWLDSENSILFAGCGDGVIYQVSLEDGRIQREYRGHTDYVHSVVGNANG-QIFSGAEDGTVRVWSTKQQQHTSMLE 193
Cdd:cd00200  137 WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLR 216

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 939619905 194 PYKNpnllrpdwgkWIGAVAVNED-WLLCGGGPKASIFHLRSMESTCVFSFPG---RVHLCDFVDD-CVLIGGEHNH 265
Cdd:cd00200  217 GHEN----------GVNSVAFSPDgYLLASGSEDGTIRVWDLRTGECVQTLSGhtnSVTSLAWSPDgKRLASGSADG 283
WD40 COG2319
WD40 repeat [General function prediction only];
11-184 1.40e-10

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.85  E-value: 1.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619905  11 NNVLAQAISGSKQYLFAGNLFGDIFVLRIKeldkgseepPGKLKIFPQGSDVDINYLAFHRD--FLIVG----AVGLiyg 84
Cdd:COG2319  247 GSVRSVAFSPDGRLLASGSADGTVRLWDLA---------TGELLRTLTGHSGGVNSVAFSPDgkLLASGsddgTVRL--- 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619905  85 leWNeeeesLATKRswevkiPMQVDAVEVPDVNSMWLDSENSILFAGCGDGVIYQVSLEDGRIQREYRGHTDYVHSVVGN 164
Cdd:COG2319  315 --WD-----LATGK------LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS 381

                        170       180
                 ....*....|....*....|.
gi 939619905 165 ANGQ-IFSGAEDGTVRVWSTK 184
Cdd:COG2319  382 PDGRtLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 115-265 1.24e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.28  E-value: 1.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619905 115 DVNSMWLDSENSILFAGCGDGVIYQVSLEDGRIQREYRGHTDYVHSVVGNANG-QIFSGAEDGTVRVWSTKQQQHTSMLE 193
Cdd:cd00200  137 WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLR 216

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 939619905 194 PYKNpnllrpdwgkWIGAVAVNED-WLLCGGGPKASIFHLRSMESTCVFSFPG---RVHLCDFVDD-CVLIGGEHNH 265
Cdd:cd00200  217 GHEN----------GVNSVAFSPDgYLLASGSEDGTIRVWDLRTGECVQTLSGhtnSVTSLAWSPDgKRLASGSADG 283
WD40 COG2319
WD40 repeat [General function prediction only];
11-184 1.40e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.85  E-value: 1.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619905  11 NNVLAQAISGSKQYLFAGNLFGDIFVLRIKeldkgseepPGKLKIFPQGSDVDINYLAFHRD--FLIVG----AVGLiyg 84
Cdd:COG2319  247 GSVRSVAFSPDGRLLASGSADGTVRLWDLA---------TGELLRTLTGHSGGVNSVAFSPDgkLLASGsddgTVRL--- 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619905  85 leWNeeeesLATKRswevkiPMQVDAVEVPDVNSMWLDSENSILFAGCGDGVIYQVSLEDGRIQREYRGHTDYVHSVVGN 164
Cdd:COG2319  315 --WD-----LATGK------LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS 381

                        170       180
                 ....*....|....*....|.
gi 939619905 165 ANGQ-IFSGAEDGTVRVWSTK 184
Cdd:COG2319  382 PDGRtLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
116-226 2.79e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.08  E-value: 2.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619905 116 VNSMWLDSENSILFAGCGDGVIYQVSLEDGRIQREYRGHTDYVHSVVGNANGQ-IFSGAEDGTVRVWSTKQQQHTSMLEP 194
Cdd:COG2319  123 VRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKlLASGSDDGTVRLWDLATGKLLRTLTG 202

                         90       100       110
                 ....*....|....*....|....*....|....
gi 939619905 195 YKNpnllrpdwgkWIGAVAVNED--WLLCGGGPK 226
Cdd:COG2319  203 HTG----------AVRSVAFSPDgkLLASGSADG 226
WD40 pfam00400
WD domain, G-beta repeat;
145-182 1.63e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.63e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 939619905  145 GRIQREYRGHTDYVHSVVGNANGQ-IFSGAEDGTVRVWS 182
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKlLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 144-182 1.89e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 1.89e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 939619905   144 DGRIQREYRGHTDYVHSVVGNANGQIF-SGAEDGTVRVWS 182
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLaSGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 115-265 1.24e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.28  E-value: 1.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619905 115 DVNSMWLDSENSILFAGCGDGVIYQVSLEDGRIQREYRGHTDYVHSVVGNANG-QIFSGAEDGTVRVWSTKQQQHTSMLE 193
Cdd:cd00200  137 WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLR 216

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 939619905 194 PYKNpnllrpdwgkWIGAVAVNED-WLLCGGGPKASIFHLRSMESTCVFSFPG---RVHLCDFVDD-CVLIGGEHNH 265
Cdd:cd00200  217 GHEN----------GVNSVAFSPDgYLLASGSEDGTIRVWDLRTGECVQTLSGhtnSVTSLAWSPDgKRLASGSADG 283
WD40 COG2319
WD40 repeat [General function prediction only];
11-184 1.40e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.85  E-value: 1.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619905  11 NNVLAQAISGSKQYLFAGNLFGDIFVLRIKeldkgseepPGKLKIFPQGSDVDINYLAFHRD--FLIVG----AVGLiyg 84
Cdd:COG2319  247 GSVRSVAFSPDGRLLASGSADGTVRLWDLA---------TGELLRTLTGHSGGVNSVAFSPDgkLLASGsddgTVRL--- 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619905  85 leWNeeeesLATKRswevkiPMQVDAVEVPDVNSMWLDSENSILFAGCGDGVIYQVSLEDGRIQREYRGHTDYVHSVVGN 164
Cdd:COG2319  315 --WD-----LATGK------LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS 381

                        170       180
                 ....*....|....*....|.
gi 939619905 165 ANGQ-IFSGAEDGTVRVWSTK 184
Cdd:COG2319  382 PDGRtLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
116-226 2.79e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.08  E-value: 2.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619905 116 VNSMWLDSENSILFAGCGDGVIYQVSLEDGRIQREYRGHTDYVHSVVGNANGQ-IFSGAEDGTVRVWSTKQQQHTSMLEP 194
Cdd:COG2319  123 VRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKlLASGSDDGTVRLWDLATGKLLRTLTG 202

                         90       100       110
                 ....*....|....*....|....*....|....
gi 939619905 195 YKNpnllrpdwgkWIGAVAVNED--WLLCGGGPK 226
Cdd:COG2319  203 HTG----------AVRSVAFSPDgkLLASGSADG 226
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 116-251 8.15e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.89  E-value: 8.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619905 116 VNSMWLDSENSILFAGCGDGVIYQVSLEDGRIQREYRGHTDYVHSVVGNANG-QIFSGAEDGTVRVWSTKQQQHTSMLEP 194
Cdd:cd00200   12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGtYLASGSSDKTIRLWDLETGECVRTLTG 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619905 195 YKnpnllrpdwgKWIGAVAVNED--WLLCGGGPK-ASIFHLRSmeSTCVFSFPGrvHLCD 251
Cdd:cd00200   92 HT----------SYVSSVAFSPDgrILSSSSRDKtIKVWDVET--GKCLTTLRG--HTDW 137
WD40 COG2319
WD40 repeat [General function prediction only];
51-224 1.41e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.77  E-value: 1.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619905  51 GKLKIFPQGSDVDINYLAFHRD--FLIVGAVG---LIYGLEWNEEEESLATKRSWevkipmqvdavevpdVNSMWLDSEN 125
Cdd:COG2319  236 GKLLRTLTGHSGSVRSVAFSPDgrLLASGSADgtvRLWDLATGELLRTLTGHSGG---------------VNSVAFSPDG 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619905 126 SILFAGCGDGVIYQVSLEDGRIQREYRGHTDYVHSVVGNANGQ-IFSGAEDGTVRVWSTKQQQHTSMLEPYKNpnllrpd 204
Cdd:COG2319  301 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKtLASGSDDGTVRLWDLATGELLRTLTGHTG------- 373

                        170       180
                 ....*....|....*....|..
gi 939619905 205 wgkWIGAVAVNED--WLLCGGG 224
Cdd:COG2319  374 ---AVTSVAFSPDgrTLASGSA 392
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 116-182 1.38e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.42  E-value: 1.38e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 939619905 116 VNSMWLDSENSILFAGCGDGVIYQVSLEDGRIQREYRGHTDYVHSVVGNANGQ-IFSGAEDGTVRVWS 182
Cdd:cd00200  222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKrLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
116-223 1.76e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.69  E-value: 1.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619905 116 VNSMWLDSENSILFAGCGDGVIYQVSLEDGRIQREYRGHTDYVHSVVGNANGQ-IFSGAEDGTVRVWSTKQQQHTSMLEP 194
Cdd:COG2319  207 VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRlLASGSADGTVRLWDLATGELLRTLTG 286

                         90       100       110
                 ....*....|....*....|....*....|.
gi 939619905 195 YKNpnllrpdwgkWIGAVAVNED--WLLCGG 223
Cdd:COG2319  287 HSG----------GVNSVAFSPDgkLLASGS 307
WD40 COG2319
WD40 repeat [General function prediction only];
116-224 5.56e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.07  E-value: 5.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619905 116 VNSMWLDSENSILFAGCGDGVIYQVSLEDGRIQREYRGHTDYVHSVVGNANGQ-IFSGAEDGTVRVWSTKQQQHTSMLEP 194
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKtLASGSADGTVRLWDLATGKLLRTLTG 160

                         90       100       110
                 ....*....|....*....|....*....|..
gi 939619905 195 YKNpnllrpdwgkWIGAVAVNED--WLLCGGG 224
Cdd:COG2319  161 HSG----------AVTSVAFSPDgkLLASGSD 182
WD40 pfam00400
WD domain, G-beta repeat;
145-182 1.63e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.63e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 939619905  145 GRIQREYRGHTDYVHSVVGNANGQ-IFSGAEDGTVRVWS 182
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKlLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 144-182 1.89e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 1.89e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 939619905   144 DGRIQREYRGHTDYVHSVVGNANGQIF-SGAEDGTVRVWS 182
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLaSGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 123-197 2.31e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 39.28  E-value: 2.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619905  123 SENSILFAGCGDGVIYQVSLEDGRIQREYRGHTDYVHSVVGNANGQIF-SGAEDGTVRVW-------STKQQQHTSMLEP 194
Cdd:pfam20426  92 SENFLISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILaTGSYDTTVMVWevlrgrsSEKRSRNTQTEFP 171


                  ...
gi 939619905  195 YKN 197
Cdd:pfam20426 172 RKD 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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