BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619957  27 HTDCTFIIEDESggsqsFPCHKLLFSCASDVFDRMLYGDYIESTSGVVRLNDVQPDIFEKFRDYVYGYECDKlqkyDFDT 106
Cdd:cd18186    1 LCDVTLVVGGRE-----FPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELEL----SEEN 71

                         90
                 ....*....|.
gi 939619957 107 LIRLCEFANKY 117
Cdd:cd18186   72 VEELLAAADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619957  27 HTDCTFIIEDESggsqsFPCHKLLFSCASDVFDRMLYGDYIESTSGVVRLNDVQPDIFEKFRDYVYGYECDKlqkyDFDT 106
Cdd:cd18186    1 LCDVTLVVGGRE-----FPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELEL----SEEN 71

                         90
                 ....*....|.
gi 939619957 107 LIRLCEFANKY 117
Cdd:cd18186   72 VEELLAAADKL 82

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619957    29 DCTFIIEDesggsQSFPCHKLLFSCASDVFDRMLYGDYIESTSGVVRLNDVQPDIFEKFRDYVYGYECDKLQkydfDTLI 108
Cdd:smart00225   1 DVTLVVGG-----KKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPE----ENVE 71

                           90       100
                   ....*....|....*....|....*
gi 939619957   109 RLCEFANKYLVQSLEEDCVKDLLIR 133
Cdd:smart00225  72 ELLELADYLQIPGLVELCEEFLLKL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619957  27 HTDCTFIIEDESggsqsFPCHKLLFSCASDVFDRMLYGDYIESTSGVVRLNDVQPDIFEKFRDYVYGYECDKlqkyDFDT 106
Cdd:cd18186    1 LCDVTLVVGGRE-----FPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELEL----SEEN 71

                         90
                 ....*....|.
gi 939619957 107 LIRLCEFANKY 117
Cdd:cd18186   72 VEELLAAADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619957  28 TDCTFIIEDEsGGSQSFPCHKLLFSCASDVFDRMLYGDYIESTSGVVrLNDVQPDIFEKFRDYVYgyeCDKLQkYDFDTL 107
Cdd:cd18282    8 ADVHFIVGPP-GGTQRIPAHKYVLATGSSVFYAMFYGGLAENKNEIE-IPDVEPAAFLNLLRYLY---CDEID-LEPDTV 81

                         90       100
                 ....*....|....*....|
gi 939619957 108 IRLCEFANKYLVQSLEEDCV 127
Cdd:cd18282   82 LATLYAAKKYLVPHLARACV 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619957  27 HTDCTFIIEDesggsQSFPCHKLLFSCASDVFDRMLYGDYIESTSGVVRLNDVQPDIFEKFRDYVY-GYEcdKLQKYDFD 105
Cdd:cd18287   22 YSDVTFVVEE-----KRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYtGRL--TLTDLKED 94

                         90
                 ....*....|....*....
gi 939619957 106 TLIRLCEFANKYLVQSLEE 124
Cdd:cd18287   95 VLLDVLGLAHQYGFEELEA 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619957  10 PNSKMRSCMMELGRTNRHTDCTFIIedesgGSQSFPCHKLLFSCASDVFDRMLYGDYIESTSGVVRLNDVQPDIFEKFRD 89
Cdd:cd18279    1 PECRLAEDLGNLWENSRFTDCCLCV-----GGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMR 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 939619957  90 YVYGYECDKLQKYDFDTLIRlcefANKYLVQSL---EEDCVKDLLIRKN 135
Cdd:cd18279   76 FIYTGKAPNLDKMADDLLAA----ADKYALERLkvmCEDALCSNLSVEN 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619957   9 LPNSKMRSCMMELGRTNRHTDCTFIIedesgGSQSFPCHKLLFSCASDVFDRMLYGDYIESTSGVVRLNDVQPDIFEKFR 88
Cdd:cd18343    3 VPECRLAEDLGNLWENSRFTDCSLFV-----GGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMM 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 939619957  89 DYVYGYECDKLQKYDfDTLIRLcefANKYLVQSLEEDCVKDL 130
Cdd:cd18343   78 RFIYTGKAPNLDKMA-DNLLAA---ADKYALERLKVMCEEAL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619957  28 TDCTFIIEDESGgSQSFPCHKLLFSCASDVFDRMLYGDyIESTSGVVRLNDVQPDIFEKFRDYVYGYECDklqkYDFDTL 107
Cdd:cd18281   23 SDVHFIVGKGDN-EQRIPAHKFVLSIGSAVFDAMFNGG-MATTSAEIELPDVEPAAFLALLRFLYSDEVQ----IGPETV 96

                         90       100
                 ....*....|....*....|...
gi 939619957 108 IRLCEFANKYLVQSLEEDCVKDL 130
Cdd:cd18281   97 MTTLYTAKKYAVPALESACVEFL 119

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619957  29 DCTFIIEDesggsQSFPCHKLLFSCASDVFDRMLYGDYIESTSGVVRLNDVQPDIFEKFRDYVYGYECDKLQ-------- 100
Cdd:cd18300   11 DVTFIVED-----GTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPILEdgdcvgli 85

                         90       100
                 ....*....|....*....|....*.
gi 939619957 101 ----KYDFDTLIRLCEfanKYLVQSL 122
Cdd:cd18300   86 vlanRLCLPRLVALCE---QYIVKEL 108

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619957  40 GSQSFPCHKLLFSCASDVFDRMLYGDYIESTSGVVRLNDVQPDIFEKFRDYVYGYECDKLQKYDFDTLIrlceFANKYLV 119
Cdd:cd18314   14 GDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLM----LASKYQV 89

                 ....*..
gi 939619957 120 QSLEEDC 126
Cdd:cd18314   90 PDLEKLC 96

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619957  28 TDCTFIIEDESggsqsFPCHKLLFSCASDVFDRMLYGDYIESTSG-----VVRLNDVQPDIFEKFRDYVYGYECDKLQKY 102
Cdd:cd18296   18 PDVCFQVEGHR-----FPCHKAFFCGRSDYFKALLRDHFAESEENngsipVVTLHDVSPEVFAIVLYYIYTDDTDLPPEN 92

                         90       100
                 ....*....|....*....|....
gi 939619957 103 DFDTLIrlceFANKYLVQSLEEDC 126
Cdd:cd18296   93 AYDVLY----VADMYLLPGLKRLC 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619957   9 LPNSKMRsCMMELGRTNRHTDCTFIIEDesggsQSFPCHKLLFSCASDVFDRMLYGDYIESTSGVVRLNDVQPDIFEKFR 88
Cdd:cd18237    4 LLADFMG-VMNNMRKQKTLCDVILIVEG-----REIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLV 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 939619957  89 DYVYGYECDklqkYDFDTLIRLCEFANKYLVQSLEEDCVKDL 130
Cdd:cd18237   78 EFAYTARIS----VNSNNVQSLLDAANQYQIEPVKKMCVDFL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619957  38 SGGSQSFPCHKLLFSCASDVFDRMLYGDyIESTSGVVRLNDVQPDIFEKFRDYVYGyecDKLQkYDFDTLIRLCEFANKY 117
Cdd:cd18346   38 GPGAQRIPAHRFVLAAGSAVFDAMFNGG-MATTSAEIELPDVEPAAFLALLRFLYS---DEVQ-IGPETVMTTLYTAKKY 112

                         90
                 ....*....|...
gi 939619957 118 LVQSLEEDCVKDL 130
Cdd:cd18346  113 AVPALEAHCVEFL 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619957  40 GSQSFPCHKLLFSCASDVFDRMLYGdyiESTSGVVRLNDVQPDIFEKFRDYVYGyECDKLQKYDFDTLIRlcefANKYL- 118
Cdd:cd18218   26 GSQEFPAHSLVLAGASQQLGRQLTN---PNPGQWCLGEGISPSTFKQLLDFVYG-ESVEVQPGELRPLLE----AARALe 97

                         90
                 ....*....|..
gi 939619957 119 VQSLEEDCVKDL 130
Cdd:cd18218   98 VESLEEACWRAL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619957   9 LPNSKMRSCMMELGRTNRHTDCTFIIedesgGSQSFPCHKLLFSCASDVFDRMLYGDYIESTSGVVRLNDVQPDIFEKFR 88
Cdd:cd18342    4 VPECRLADELGGLWENSRFTDCCLCV-----AGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMM 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 939619957  89 DYVYGYECDKLQKYDFDTLIRlcefANKYLVQSLEEDCVKDL 130
Cdd:cd18342   79 CFIYTGKAPNLDKMADDLLAA----ADKYALERLKVMCEDAL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 939619957  20 ELGRTNRHTDCTFIIedesgGSQSFPCHKLLFSCASDVFDRMLYGDYIESTSGVVRLNDVQPDIFEKFRDYVYGYECD 97
Cdd:cd18341   20 ELLDENKFVDCTLKA-----GDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLYSAEID 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619957  26 RHTDCTFIIEDESggsQSFPCHKLLFSCASDVFDRMLY-GDYIESTSGVVRLNDVQPDIFEKFRDYVYGyECDKLQKydf 104
Cdd:cd18294   13 EFSDVKFLVGPER---QEIFAHKCILAARCEVFRAMFLtGPQKESTQSPLVLSDIEPEVFRAVLEFIYT-NCVTLSN--- 85

                         90       100
                 ....*....|....*....|....
gi 939619957 105 DTLIRLCEFANKYLVQSLEEDCVK 128
Cdd:cd18294   86 HTVIEVLAAAVEYGLDELRKLCER 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 939619957  25 NRHTDCTFIIEDesggsQSFPCHKLLFSCASDVFDRMLYGDYIESTSGVVRLNDVQPDIFEKFRDYVYGYE 95
Cdd:cd18340   25 NKFVDCVLKIKE-----KEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSE 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619957  40 GSQSFPCHKLLFSCASDVFDRMLYGDYIESTSGVVRLNDVQPDIFEKFRDYVYGyecDKLQkYDFDTLIRLCEFANKYLV 119
Cdd:cd18265   31 DGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYG---GGLR-IQEDNVESVLEASDLLQV 106

                         90
                 ....*....|.
gi 939619957 120 QSLEEDCVKDL 130
Cdd:cd18265  107 SKLREACVRFL 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 939619957  40 GSQSFPCHKLLFSCASDVFDRMLYGDYIESTSGVVRLNDVQPDIFEKFRDYVY 92
Cdd:cd18242   29 EGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVY 81

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619957  44 FPCHKLLFSCASDVFDRMLYGDYIESTSGVVRLNDVQPDIFEKFRDYVYGYECDKL-QKYDFDTLIRLCEFANKYLVQSL 122
Cdd:cd18302   18 FPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEASAVkESQNVEFLCNVLVIADQLLITRL 97

                 ....
gi 939619957 123 EEDC 126
Cdd:cd18302   98 KEIC 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619957  11 NSKMRSCMMelgrtnrhTDCTFIiedesGGSQSFPCHKLLFSCASDVFDRMLYGDYIESTSGVVRLND-VQPDIFEKFRD 89
Cdd:cd18254   14 NTLRKQCMF--------TDVTLW-----AGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHDsLHPEVLELLLD 80

                 ...
gi 939619957  90 YVY 92
Cdd:cd18254   81 FAY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619957  28 TDCTFIIEDesggsQSFPCHKLLFSCASDVFDRMLYGDYIESTSGVVRLNDVQPDIFEKFRDYVYGYEC--------DKL 99
Cdd:cd18255   19 LDVTLIADG-----QRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTSELtldldciqDVL 93

                         90       100
                 ....*....|....*....|....*...
gi 939619957 100 QKYDFDTLIRLCEFANKYLVQSLE-EDC 126
Cdd:cd18255   94 GAAVHLQMLPVVELCEEFLKSAMSvENC 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619957  20 ELGRTNRHTDCTFIIEDesggsQSFPCHKLLFSCASDVFDRMLYGDYIESTsgvvrLNDVQPDIFEKFRDYVYGYECDkl 99
Cdd:cd18303   11 SLFDKELYSDITIKLAD-----KSIPAHKFVLAARSEKWSNENLASTNELD-----LSDISYEVVLALLRWLYTDELD-- 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 939619957 100 QKYDFDTLIRLCEFANKYLVQSLEEDCVKDLLIRKNT 136
Cdd:cd18303   79 LTLDDEFLLELMKAAKRFQLTDLVERCERALMSSVNV 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 939619957  40 GSQSFPCHKLLFSCASDVFDRMLYGDYIESTSGVVRLNDVQPDIFEKFRDYVY 92
Cdd:cd18336   27 GNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAY 79

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 939619957  40 GSQSFPCHKLLFSCASDVFdRMLYGDYIESTS-----GVVRLNDVQPDIFEKFRDYVYGYECDKL 99
Cdd:cd18301   26 GGKTFPAHKFILASRSDYF-RKLFLSSLLTSEdavgcDVVHIEKVPPEIFEQLLQFIYTDTCDLL 89

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619957  12 SKMRSCMMElgrtNRHTDCTFIIEDesgGSQSfpCHKLLFSCASDVFDRMLYGDYIESTSGVVRLNDVQPDIFEKFRDYV 91
Cdd:cd18358    9 NRIKECLSK----GTFSDVTFKLDD---GTIN--AHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKVSMQAVLDYL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 939619957  92 YGYECDKLQKYDFDTLIRLC-EFANKYLVQSLEEDCVKDLL 131
Cdd:cd18358   80 YTKQLSPTADLDPLELIALAnRFCLPHLVALTEQHAVQELT 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 939619957  28 TDCTFiiedESGGSQSFPCHKLLFSCASDVFDRMLYGDYIESTSGVVRLNDVQPDIFEKFRDYVY 92
Cdd:cd18252   22 TDITL----QCASGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVY 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 939619957  29 DCTFIIEDESggsqsFPCHKLLFSCASDVFDRMLYGDYIESTSGVVRLNDVQPDIFEKFRDYVY 92
Cdd:cd18271   26 DFNIIVKDET-----IPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAY 84