second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619971 1110 PRRLGEDLLKMFLQEIATDMLVEVHGRRIRAHKCILRSRCQYFAAMLAGHG---SQSVVSLQGYSYAAVHFALCHIYSGA 1186
Cdd:cd18286     1 CSRLGKDLLQLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWaesNSSEITLTGVSHAAVSFVLLFIYGGV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 939619971 1187 SHPPDGISLMELAALADLLGLEGLKEVTAHALKTNYCHNFH 1227
Cdd:cd18286    81 LDLPDDVNLGELLSLADMYGLDGLKDVVAYTLRRDYCHFFH 121

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619971  1309 AQLSAYRWGHVCEQLVREILEAAyayvgdhfaSLIASDSFLSLGHDRSRHIPRLetlLLHTAA-ELTPEQACRSYQRVTR 1387
Cdd:TIGR00618  251 AQEEQLKKQQLLKQLRARIEELR---------AQEAVLEETQERINRARKAAPL---AAHIKAvTQIEQQAQRIHTELQS 318

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619971  1388 LNTVLqAKVIHMPASLGQSELARELQGLQEEQLDWQPEYIRLVGALVYAVEQCLIRQCSRAMRVTAWQRMDLELRKKIQT 1467
Cdd:TIGR00618  319 KMRSR-AKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQS 397

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 939619971  1468 LARLTEPLDMKRQNGKPVGKAFSfggsTRSQDLVQIKLAIQAQTKRANAQETLMYKATQTQDAA 1531
Cdd:TIGR00618  398 LCKELDILQREQATIDTRTSAFR----DLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLE 457

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619971 1110 PRRLGEDLLKMFLQEIATDMLVEVHGRRIRAHKCILRSRCQYFAAMLAGHG---SQSVVSLQGYSYAAVHFALCHIYSGA 1186
Cdd:cd18286     1 CSRLGKDLLQLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWaesNSSEITLTGVSHAAVSFVLLFIYGGV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 939619971 1187 SHPPDGISLMELAALADLLGLEGLKEVTAHALKTNYCHNFH 1227
Cdd:cd18286    81 LDLPDDVNLGELLSLADMYGLDGLKDVVAYTLRRDYCHFFH 121

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 939619971  1117 LLKMFLQEIATDMLVEVHGRRIRAHKCILRSRCQYFAAMLAGHG---SQSVVSLQGYSYAAVHFALCHIYSG 1185
Cdd:pfam00651    1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQEsesSVSEITLDDVSPEDFEALLEFMYTG 72

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 939619971   1238 LQVLPVALNHALDDLYRKCLRWTCRHYLKVWPTRQFAQLPPDIL 1281
Cdd:smart00875    2 LGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQL 45

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619971 1110 PRRLGEDLLKMFLQEIATDMLVEVHGRRIRAHKCILRSRCQYFAAMLAGHG---SQSVVSLQGYSYAAVHFALCHIYSGA 1186
Cdd:cd18286     1 CSRLGKDLLQLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWaesNSSEITLTGVSHAAVSFVLLFIYGGV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 939619971 1187 SHPPDGISLMELAALADLLGLEGLKEVTAHALKTNYCHNFH 1227
Cdd:cd18286    81 LDLPDDVNLGELLSLADMYGLDGLKDVVAYTLRRDYCHFFH 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 939619971 1127 TDMLVEVHGRRIRAHKCILRSRCQYFAAMLAGH---GSQSVVSLQGYSYAAVHFALCHIYSG 1185
Cdd:cd18186     2 CDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGmkeSSSSEIELDDVSPEAFEALLDYIYTG 63

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 939619971 1115 EDLLKMFLQEIATDMLVEVHGRRIRAHKCILRSRCQYFAAMLAGH---GSQSVVSLQGYSYaAVHFA-LCHIYSG 1185
Cdd:cd18298     1 DSLRKAFNDPRTSDLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHwneDDKNVIEIDQYSY-PVYYAfLRYLYTD 74

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 939619971  1117 LLKMFLQEIATDMLVEVHGRRIRAHKCILRSRCQYFAAMLAGHG---SQSVVSLQGYSYAAVHFALCHIYSG 1185
Cdd:pfam00651    1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQEsesSVSEITLDDVSPEDFEALLEFMYTG 72

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 939619971 1119 KMFL-QEIATDMLVEVHGRRIRAHKCILRSRCQYFAAMLAG---HGSQSVVSLQGYSYAAVHFALCHIYSG 1185
Cdd:cd18300     1 KLFLnKGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGnfrESSAKEVELPGVSKETFLALLEYLYTD 71

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619971 1111 RRLGEDLLKMFLQEIAT-DMLVEVHGRRIRAHKCILRSRCQYFAAMLAGH--------GSQSVVSLQGYSYAAVHFALCH 1181
Cdd:cd18296     1 RVDLDELPFPPEQELSFpDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHfaeseennGSIPVVTLHDVSPEVFAIVLYY 80

                  ....
gi 939619971 1182 IYSG 1185
Cdd:cd18296    81 IYTD 84

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 939619971 1115 EDLLKMFLQEIATDMLVEVHGRRIRAHKCILRSRCQYFAAMLAG 1158
Cdd:cd18295     8 EFLRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFET 51

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 939619971 1118 LKMFLQEIA---TDMLVEVHGRRIRAHKCILRSRCQYFAAM 1155
Cdd:cd18309     9 MEAFLESVGgdfCDITLLLDGHPIPAHKAILAARCSYFEAM 49

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619971 1108 RQPRRLGEDLLKMFLQEIATDMLVEVHGRRIRAHKCILRSRCQYFAAMLAG---HGSQSVVSLQGYSYAAVHFALCHIYS 1184
Cdd:cd18256     2 KHASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGgmsESSKDVVQIHGVEPDIFHILLDFIYT 81

                  .
gi 939619971 1185 G 1185
Cdd:cd18256    82 G 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 939619971 1125 IATDMLVEVHGRRIRAHKCILRSRCQYFAAMLAGH---GSQSVVSLQGYSYAAVHFALCHIYSG 1185
Cdd:cd18265    22 TFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHlkeSRQAVVEIQKVSAAAMEVLLDYMYGG 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 939619971 1112 RLGEDLLKMFLQEIATDMLVEVHGRRIRAHKCILRSRCQYFAAM 1155
Cdd:cd18345     4 RLSDDLGLLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAM 47

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 939619971 1112 RLGEDLLKMFLQEIATDMLVEVHGRRIRAHKCILRSRCQYFAAM 1155
Cdd:cd18279     4 RLAEDLGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAM 47

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619971  1309 AQLSAYRWGHVCEQLVREILEAAyayvgdhfaSLIASDSFLSLGHDRSRHIPRLetlLLHTAA-ELTPEQACRSYQRVTR 1387
Cdd:TIGR00618  251 AQEEQLKKQQLLKQLRARIEELR---------AQEAVLEETQERINRARKAAPL---AAHIKAvTQIEQQAQRIHTELQS 318

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939619971  1388 LNTVLqAKVIHMPASLGQSELARELQGLQEEQLDWQPEYIRLVGALVYAVEQCLIRQCSRAMRVTAWQRMDLELRKKIQT 1467
Cdd:TIGR00618  319 KMRSR-AKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQS 397

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 939619971  1468 LARLTEPLDMKRQNGKPVGKAFSfggsTRSQDLVQIKLAIQAQTKRANAQETLMYKATQTQDAA 1531
Cdd:TIGR00618  398 LCKELDILQREQATIDTRTSAFR----DLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLE 457

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 939619971 1135 GRRIRAHKCILRSRCQYFAAMLAGHGSQS--VVSLQGYSYAAVHFALCHIYSG 1185
Cdd:cd18315    10 GGSLKAHKLVLAAASPYFAALLKETPPDEhpVIILPDVPYSELKALLDFIYTG 62