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Conserved domains on  [gi|948284321|ref|NP_001303864|]
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intraflagellar transport protein 25 homolog isoform a [Homo sapiens]

Protein Classification

discoidin domain-containing protein( domain architecture ID 10465410)

discoidin domain-containing protein similar to intraflagellar transport protein 25 (IFT25) that links signal-dependent movement of Hedgehog components to intraflagellar transport and to Clostridium perfringens family 31 glycoside hydrolase

CATH:  2.60.120.260
Gene Ontology:  GO:0030246
PubMed:  9684896|17702679
SCOP:  4002466

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 19-125 2.90e-08

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


:

Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 48.98  E-value: 2.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284321   19 TSSDEKHPPENIIDGNPETFWTTTGMFPQEFI-ICFHKHVRIERLVIQ------SYFVQTLKIEKSTskepvDFEQWIEK 91
Cdd:pfam00754   6 SSYSGEGPAAAALDGDPNTAWSAWSGDDPQWIqVDLGKPKKITGVVTQgrqdgsNGYVTSYKIEYSL-----DGENWTTV 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 948284321   92 DLVHTEGQLQNEEIVAHD----GSATYLRFIIVSAFDH 125
Cdd:pfam00754  81 KDEKIPGNNDNNTPVTNTfdppIKARYVRIVPTSWNGG 118
 
Name Accession Description Interval E-value
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 19-125 2.90e-08

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 48.98  E-value: 2.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284321   19 TSSDEKHPPENIIDGNPETFWTTTGMFPQEFI-ICFHKHVRIERLVIQ------SYFVQTLKIEKSTskepvDFEQWIEK 91
Cdd:pfam00754   6 SSYSGEGPAAAALDGDPNTAWSAWSGDDPQWIqVDLGKPKKITGVVTQgrqdgsNGYVTSYKIEYSL-----DGENWTTV 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 948284321   92 DLVHTEGQLQNEEIVAHD----GSATYLRFIIVSAFDH 125
Cdd:pfam00754  81 KDEKIPGNNDNNTPVTNTfdppIKARYVRIVPTSWNGG 118
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 16-89 6.45e-04

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 37.72  E-value: 6.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284321  16 ILATSSDEKHPPENIIDGNPETFWTTTGMFPQEFI-ICFHKHVRIERLVIQ-------SYFVQTLKIEKSTskepvDFEQ 87
Cdd:cd00057   14 ITASSSYSSGWEASRARLNSDNAWTPAVNDPPQWLqVDLGKTRRVTGIQTQgrkgggsSEWVTSYKVQYSL-----DGET 88


                 ..
gi 948284321  88 WI 89
Cdd:cd00057   89 WT 90
 
Name Accession Description Interval E-value
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 19-125 2.90e-08

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 48.98  E-value: 2.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284321   19 TSSDEKHPPENIIDGNPETFWTTTGMFPQEFI-ICFHKHVRIERLVIQ------SYFVQTLKIEKSTskepvDFEQWIEK 91
Cdd:pfam00754   6 SSYSGEGPAAAALDGDPNTAWSAWSGDDPQWIqVDLGKPKKITGVVTQgrqdgsNGYVTSYKIEYSL-----DGENWTTV 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 948284321   92 DLVHTEGQLQNEEIVAHD----GSATYLRFIIVSAFDH 125
Cdd:pfam00754  81 KDEKIPGNNDNNTPVTNTfdppIKARYVRIVPTSWNGG 118
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 16-89 6.45e-04

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 37.72  E-value: 6.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284321  16 ILATSSDEKHPPENIIDGNPETFWTTTGMFPQEFI-ICFHKHVRIERLVIQ-------SYFVQTLKIEKSTskepvDFEQ 87
Cdd:cd00057   14 ITASSSYSSGWEASRARLNSDNAWTPAVNDPPQWLqVDLGKTRRVTGIQTQgrkgggsSEWVTSYKVQYSL-----DGET 88


                 ..
gi 948284321  88 WI 89
Cdd:cd00057   89 WT 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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