BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450  15 FSRSLLETLNGQRLGGHFCDVTVRIREASLRAHRCVLAAGSPFFQDKLLLGHSEIRVPPVVPAQTVRQLVEFLYSGSLVV 94
Cdd:cd18229    1 FSKSLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLGHSEIEVPPVVPAQTVRQLVEFMYSGSLVV 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 948284450  95 AQGEALQVLTAASVLRIQTVIDECTQIIARAR 126
Cdd:cd18229   81 AQSEALQILTAASILQIKTVIDECTQIISQSR 112

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 948284450  403 YECSHCRKTFSSRKNYTKHMFIH 425
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450  15 FSRSLLETLNGQRLGGHFCDVTVRIREASLRAHRCVLAAGSPFFQDKLLLGHSEIRVPPVVPAQTVRQLVEFLYSGSLVV 94
Cdd:cd18229    1 FSKSLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLGHSEIEVPPVVPAQTVRQLVEFMYSGSLVV 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 948284450  95 AQGEALQVLTAASVLRIQTVIDECTQIIARAR 126
Cdd:cd18229   81 AQSEALQILTAASILQIKTVIDECTQIISQSR 112

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450    34 DVTVRIREASLRAHRCVLAAGSPFFQDKLLLGHSEIRVPPV----VPAQTVRQLVEFLYSGSLVVAQGEALQVLTAASVL 109
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIylddVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*
gi 948284450   110 RIQTVIDECTQIIAR 124
Cdd:smart00225  81 QIPGLVELCEEFLLK 95

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 948284450  403 YECSHCRKTFSSRKNYTKHMFIH 425
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

zinc finger;

                           10        20
                   ....*....|....*....|...
gi 948284450   459 FQCAVCAKRFTQKSSLNVHMRTH 481
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23

zinc finger;

                           10        20
                   ....*....|....*....|...
gi 948284450   403 YECSHCRKTFSSRKNYTKHMFIH 425
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450  15 FSRSLLETLNGQRLGGHFCDVTVRIREASLRAHRCVLAAGSPFFQDKLLLGHSEIRVPPVVPAQTVRQLVEFLYSGSLVV 94
Cdd:cd18229    1 FSKSLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLGHSEIEVPPVVPAQTVRQLVEFMYSGSLVV 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 948284450  95 AQGEALQVLTAASVLRIQTVIDECTQIIARAR 126
Cdd:cd18229   81 AQSEALQILTAASILQIKTVIDECTQIISQSR 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450   9 HIHLQNFSRSLLETLNGQRLGGHFCDVTVRIREASLRAHRCVLAAGSPFFQDKLLLGHS-EIRVPPVVPAQTVRQLVEFL 87
Cdd:cd18227    2 RVEFPDFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDQVLLKNSrRIVLPDVMNPRVFENILLSC 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 948284450  88 YSGSLVVAQGEALQVLTAASVLRIQTVIDECTQII 122
Cdd:cd18227   82 YTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450  14 NFSRSLLETLNGQRLGGHFCDVTVRIREASLRAHRCVLAAGSPFFQDKLLL-GHSEIRVPPVVPAQTVRQLVEFLYSGSL 92
Cdd:cd18210    3 EITSSLLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFHDQVLLkNMSSISLPGVMDPGAFESVLASAYTGKL 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 948284450  93 VVAQGEALQVLTAASVLRIQTVIDECTQII 122
Cdd:cd18210   83 TMLADEIVNYLTVGSVLQMWHIVDKCTELL 112

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450   23 LNGQRLGGHFCDVTVRIREASLRAHRCVLAAGSPFFQDKLLLGHSEIRVPPV----VPAQTVRQLVEFLYSGSLvVAQGE 98
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEItlddVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....
gi 948284450   99 ALQVLTAASVLRIQTVIDECTQII 122
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFL 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450   9 HIHLQNFSRSLLETLNGQRLGGHFCDVTVRIREASLRAHRCVLAAGSPFFQDkllLGHSE----IRVPPVVPAQTVRQLV 84
Cdd:cd18290    4 QMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRD---LFNSSrsavVELPAAVQPQSFQQIL 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 948284450  85 EFLYSGSLVVAQGEALQVLTAASVLRIQTVIDECTQ 120
Cdd:cd18290   81 SFCYTGRLSMNVGDQFLLMYTAGFLQIQEIMEKGTE 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450  32 FCDVTVRIREASLRAHRCVLAAGSPFFQDKLLLGHSEIRVPPV----VPAQTVRQLVEFLYSGSLVVAQGEALQVLTAAS 107
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIelddVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80

                 ..
gi 948284450 108 VL 109
Cdd:cd18186   81 KL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450   9 HIHLQNFSRSLLETLNGQRLGGHFCDVTVRIREASLRAHRCVLAAGSPFFQDKLLLGHS-EIRVPPVVPAQTVRQLVEFL 87
Cdd:cd18197    2 HFKFEQQGDAVLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQFLLNQSkQVRITILQSAEVGRKLLLSC 81

                         90       100       110
                 ....*....|....*....|....*....|...
gi 948284450  88 YSGSLVVAQGEALQVLTAASVLRIQTVIDECTQ 120
Cdd:cd18197   82 YTGALEVKKKELLKYLTAASYLQMVHIVEKCTE 114

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450    34 DVTVRIREASLRAHRCVLAAGSPFFQDKLLLGHSEIRVPPV----VPAQTVRQLVEFLYSGSLVVAQGEALQVLTAASVL 109
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIylddVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*
gi 948284450   110 RIQTVIDECTQIIAR 124
Cdd:smart00225  81 QIPGLVELCEEFLLK 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450  19 LLETLNGQRLGGHFCDVTVRIREASLRAHRCVLAAGSPFFQDKLLL-----GHSEIRVPPVVPAQTVRQLVEFLYSGSLV 93
Cdd:cd18293    2 AFLQLHRQQNSGVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSepppaGQKVVLELQGLKAHTLLKLVDFLYTSELE 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 948284450  94 VAQGEALQVLTAASVLRIQTVIDECTQIIARARAP 128
Cdd:cd18293   82 VSSEEAQDVLAAARRLQISELESLCLEGGKLVKAP 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450  10 IHLQNFSRSLLETLNGQRLGGHFCDVTVRIREASLRAHRCVLAAGSPFFQdKLLLGHSEIRVPPV-----VPAQTVRQLV 84
Cdd:cd18198    3 IPFPDHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFK-KLFTSGAVVDQQNVyeidfVSPEALTALL 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 948284450  85 EFLYSGSLVVAQGEALQVLTAASVLRIQTVIDECTQII 122
Cdd:cd18198   82 EFAYTATLTVSTANVGDILSAARLLEIPCVSHVCAEIL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450  15 FSRSLLETLNGQRLGGHFCDVTVRIREASLRAHRCVLAAGSPFFQD---KLLLGHSEI--RVPPVVPAqTVRQLVEFLYS 89
Cdd:cd18306    1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFElfsSDSDGESILtvKLDGLDPD-AVEVLVNYAYT 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 948284450  90 GSLVVAQGEALQVLTAASVLRIQTVIDECTQIIAR 124
Cdd:cd18306   80 SRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLE 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450  19 LLETLNGQRLGGHFCDVTVRIREASLRAHRCVLAAGSPFFQDKLLLGHSE------IRVPPVVPAQTVRQLVEFLYSGSL 92
Cdd:cd18201    8 LLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKEscdqttVTHLDVVAVQGFSVILDFMYSGNL 87

                         90       100       110
                 ....*....|....*....|....*....|...
gi 948284450  93 VVAQGEALQVLTAASVLRIQTVIDECTQIIARA 125
Cdd:cd18201   88 VLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDA 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450  14 NFSRSLLETLNGQRLGGHFCDVTVRIREASLRAHRCVLAAGSPFFQDKLLLGHSEIRVpPVVPAQTV-----RQLVEFLY 88
Cdd:cd18256    2 KHASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSK-DVVQIHGVepdifHILLDFIY 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 948284450  89 SGSLVVAQGEALQVLTAASVLRIQTVIDECTQ 120
Cdd:cd18256   81 TGVVEVTVSNVQELLVAADMLQLTEVVEICCE 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450  16 SRSLLETLNGQRLGGHFCDVTVRIREASLRAHRCVLAAGSPFFQDKLLLGHSEIRVPPV--VPAQTV--RQLVEFLYSGS 91
Cdd:cd18266    9 SNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVelVGASYIglKAVIDFLYSSE 88

                         90       100
                 ....*....|....*....|....*....
gi 948284450  92 LVVAQGEALQVLTAASVLRIQTVIDECTQ 120
Cdd:cd18266   89 LPLDGGNIDYVLETAHLLQIWKVVDFCCE 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450  16 SRSLLETLNGQRLGGHFCDVTVRIREASLRAHRCVLAAGSPFFQDKLLLGHSEIRVPPVVPAQTVRQLVEFLYSGSLVVA 95
Cdd:cd18232    2 SVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGSVVLPESFAEVFGLLLDFFYTGELALT 81

                         90       100
                 ....*....|....*....|...
gi 948284450  96 QGEALQVLTAASVLRIQTVIDEC 118
Cdd:cd18232   82 RENRDRVLLAAKELRVPEAVELC 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450  16 SRSLLETLNGQRLGGHFCDVTVRIREASLRAHRCVLAAGSPFFQ-------DK--LLLGHSEIRVPPVVPaqtvrQLVEF 86
Cdd:cd18194    7 SRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHlfyrdrlDKrdLVRLNSDIVTAPAFG-----LLLDF 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 948284450  87 LYSGSLVVAQGEALQVLTAASVLRIQTVIDECT---QIIARARAPGT 130
Cdd:cd18194   82 MYEGRLALRDLPVEDVLAAASYLHMYDIVKVCKgrlQEKALAEADST 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450  16 SRSLLETLNGQRLGGHFCDVTVRIREASLRAHRCVLAAGSPFFQ-------DKLLLGH--SEIrvppvVPAQTVRQLVEF 86
Cdd:cd18324    7 SRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHlfykdqlDKRDIVHlnSDI-----VTAPAFALLLEF 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 948284450  87 LYSGSLVVAQGEALQVLTAASVLRIQTVIDECTQ 120
Cdd:cd18324   82 MYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKK 115

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450  33 CDVTVRIREASLRAHRCVLAAGSPFFQDKLLLGHSEIR---VP-PVVPAQTVRQLVEFLYSGSLVVAQGEALQVLTAASV 108
Cdd:cd18263   14 CDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTqsvVQlPTIPAKDLRLLISFAYSGILHLSWENLFEATCTALQ 93

                         90       100
                 ....*....|....*....|...
gi 948284450 109 LRIQTVIDECTQIIARARAPGTS 131
Cdd:cd18263   94 LQISGALALCLDFLQREISPARC 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450  18 SLLETLNGQRLGGHFCDVTVRIREASLRAHRCVLAAGSPFFQdKLLLGHSE----IRVPPVVPAQTVRQLVEFLYSGSLV 93
Cdd:cd18278   17 NILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFL-QALVGQTEndlvVSLPEEVTARGFGPLLQFAYTAKLL 95

                         90       100
                 ....*....|....*....|....*
gi 948284450  94 VAQGEALQVLTAASVLRIQTVIDEC 118
Cdd:cd18278   96 LSRENIQEVIRCAEFLRMHNLEDSC 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450  14 NFSRSLLETLNGQRLGGHFCDVTVRIREASLRAHRCVLAAGSPFFQdKLLLGHSEIRVPPVVPAQTV-RQLVEFLYSGSL 92
Cdd:cd18216    2 SHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFK-SLVLHDNLIHLDQDMVSPTVfQQILDFIYTGKL 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 948284450  93 VVAQGEAL---QVLTAASVLRIQTVIDECTQIIARA 125
Cdd:cd18216   81 LDSLFEEPnlsEVLAAANYLQLPDLAALCRSKLKRG 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450  17 RSLLETLNGQRLGGHFCDVTVRIREASLRAHRCVLAAGSPFF-----QDKLLLGHSEIRVPPVVPAQTVRQLVEFLYSGS 91
Cdd:cd18230    6 RHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFktlycQVQKTSDQATVTHLDIVTAQGFKAIIDFMYSAH 85

                         90       100       110
                 ....*....|....*....|....*....|....
gi 948284450  92 LVVAQGEALQVLTAASVLRIQTVIDECTQIIARA 125
Cdd:cd18230   86 LALTSKNVIEVMSAASYLQMTDIVQACHNFIKAA 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450  16 SRSLLETLNGQRLGGHFCDVTVRIREASLRAHRCVLAAGSPFF----QDKLLLGHSEIRVPPVVPAQTVRQLVEFLYSGS 91
Cdd:cd18215    3 ASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFysifTDQLKNNVSVINLDPEIEPEGFRILLDFMYTSR 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 948284450  92 LVVAQGEALQVLTAASVLRIQTVIDECTQII 122
Cdd:cd18215   83 LNLREGNIMAVMATAMYLQMEHVVDTCRKFI 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450  15 FSRSLLETLNGQRLGGHFCDVTVRIREASLRAHRCVLAAGSPFF------------QDKLLLGHSEirvPPVVPAqtvrq 82
Cdd:cd18247    2 LPSSGFPVMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFhamfthdmveskQDEITMQGIE---PSALEA----- 73

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 948284450  83 LVEFLYSGSLVVAQGEALQVLTAASVLRIQTVIDEC 118
Cdd:cd18247   74 LINFAYSGRIAIDTSNVQSLLVGASFLQLQSVKDAC 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284450  17 RSLLETLNGQRLGGHFCDVTVRIREASLRAHRCVLAAGSPFFQDKLLLGHSEIRVPPV----VPAQTVRQLVEFLYSGSL 92
Cdd:cd18338    6 KKAFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVrikeVDGWTLKMLIDYVYTAEI 85

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 948284450  93 VVAQGEALQVLTAASVLRIQTVIDECTQIIARARAP 128
Cdd:cd18338   86 QVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHP 121