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Conserved domains on  [gi|1005261204|ref|NP_001305131|]
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FH1/FH2 domain-containing protein 1 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FH2 pfam02181
Formin Homology 2 Domain;
642-1014 2.51e-109

Formin Homology 2 Domain;


:

Pssm-ID: 396655  Cd Length: 372  Bit Score: 347.34  E-value: 2.51e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  642 DSSALPTKRKTVKLFWRELKLAGGHGvsasrfgpcaTLWASLDPVS----VDTARLEHLFESRAKEVLPSK----KAGEG 713
Cdd:pfam02181    1 PKKTPKPKKKLKPLHWDKVRPSQDRG----------TVWDKLDDESfeldGDLSELEELFSAKAKTKKNKKsedkSSSKK 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  714 RRTMTTVLDPKRSNAINIGLTTL-PPVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIeeAQLANPDIPLGPAEN 792
Cdd:pfam02181   71 KPKEVSLLDPKRAQNIAILLRKLkLPPEEIIQAILEGDEDALDLELLENLLKMAPTKEELKKL--KEYKGDPSELGRAEQ 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  793 FLMTLASIGGLAARLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNGS----QSSGFELS 868
Cdd:pfam02181  149 FLLELSKIPRLEARLRALLFKSTFEEEIEELKPSLEALEAASEELRNSRKFKKLLELILALGNYMNDGtrrgQAKGFKLS 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  869 YLEKVSEVKDTVRRQSLLHHLCSLVLQTRPESSDLYSEIPALTRCAKVDFEQLTENLGQLERRSRAAEESLRSLAK-HEL 947
Cdd:pfam02181  229 SLLKLSDTKSTDNKTTLLHYLVKIIREKFPEVLDFSSELSHVKKAAKVNLEQLEKDVKQLERGLKKLERELELSALdEHP 308

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1005261204  948 APALRARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYLGYTPqaaREVRIMQFCHTLREFALEYR 1014
Cdd:pfam02181  309 DDKFREVLKEFLKSAEEKLDKLESLLREALELFKELVEYFGEDP---KETSPEEFFKILRDFLKEFK 372
Formin_GBD_N super family cl39720
Formin N-terminal GTPase-binding domain; This is the N-terminal GTPase-binding domain (GBD) of ...
 17-135 9.97e-56

Formin N-terminal GTPase-binding domain; This is the N-terminal GTPase-binding domain (GBD) of formins also known as formin homology domain-containing proteins (FHOD) pfam02181. This GBD is recruited by Rac and Ras GTPases in cells and plays an essential role for FHOD1-mediated actin remodelling and transcriptional activation, localizes to specific GTPases in cells, and binds to GTPases in vitro. It exhibits structural similarity to the ubiquitin superfold as found, for example, in the Ras-binding domains of c-Raf1 or PI3 kinase, but contains an unusual loop that inserts into the first FH3 repeat.


The actual alignment was detected with superfamily member pfam18382:

Pssm-ID: 465735  Cd Length: 119  Bit Score: 188.72  E-value: 9.97e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204   17 TVRVQYLEDTDPFAC-ANFPEPRRAPTCSLDGALPLGAQIPAVHRLLGAPLKLEDCALQV---SPSGYYLDTELSLEEQR 92
Cdd:pfam18382    1 TCRVQYLNDTDPFACtSNFPEPTRPPTFTFNEDLPLSEQLAGVHRLLQAPHKLEDCALQVyrdGDYGNYLDLDSSLAEQR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1005261204   93 EMLEGFYEEiskgRKPTLILRTQLSVRVNAILEKLYSSSGPEL 135
Cdd:pfam18382   81 EELEGFQED----RKNSLVLRTQLSVRVHAIIEKLLNSSGREL 119
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 337-553 9.47e-07

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 53.15  E-value: 9.47e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  337 EDGDIEEAPGAGGRRERRKP-SSEEGKRSRRSlegggCPARAPEPG--------PTGPASPVGPTSSTGPALLTGP--AS 405
Cdd:PTZ00449   530 EEGEHEDSKESDEPKEGGKPgETKEGEVGKKP-----GPAKEHKPSkiptlskkPEFPKDPKHPKDPEEPKKPKRPrsAQ 604

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  406 SPVGPPSGLQASVNLFPTISVAPSADTSSERSIYKlHQTASVWAPESPPVPQSP--PGQAR--LEARFLENVAAAETEKq 481
Cdd:PTZ00449   605 RPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPP-QRPSSPERPEGPKIIKSPkpPKSPKppFDPKFKEKFYDDYLDA- 682

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1005261204  482 valAQGRAETLAGAMPNEAGGHPDARQLwdsPETAPAARTPQSPAPCVLLRAQRSLAPEPKEPLIPASPKAE 553
Cdd:PTZ00449   683 ---AAKSKETKTTVVLDESFESILKETL---PETPGTPFTTPRPLPPKLPRDEEFPFEPIGDPDAEQPDDIE 748
 
Name Accession Description Interval E-value
FH2 pfam02181
Formin Homology 2 Domain;
642-1014 2.51e-109

Formin Homology 2 Domain;


Pssm-ID: 396655  Cd Length: 372  Bit Score: 347.34  E-value: 2.51e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  642 DSSALPTKRKTVKLFWRELKLAGGHGvsasrfgpcaTLWASLDPVS----VDTARLEHLFESRAKEVLPSK----KAGEG 713
Cdd:pfam02181    1 PKKTPKPKKKLKPLHWDKVRPSQDRG----------TVWDKLDDESfeldGDLSELEELFSAKAKTKKNKKsedkSSSKK 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  714 RRTMTTVLDPKRSNAINIGLTTL-PPVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIeeAQLANPDIPLGPAEN 792
Cdd:pfam02181   71 KPKEVSLLDPKRAQNIAILLRKLkLPPEEIIQAILEGDEDALDLELLENLLKMAPTKEELKKL--KEYKGDPSELGRAEQ 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  793 FLMTLASIGGLAARLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNGS----QSSGFELS 868
Cdd:pfam02181  149 FLLELSKIPRLEARLRALLFKSTFEEEIEELKPSLEALEAASEELRNSRKFKKLLELILALGNYMNDGtrrgQAKGFKLS 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  869 YLEKVSEVKDTVRRQSLLHHLCSLVLQTRPESSDLYSEIPALTRCAKVDFEQLTENLGQLERRSRAAEESLRSLAK-HEL 947
Cdd:pfam02181  229 SLLKLSDTKSTDNKTTLLHYLVKIIREKFPEVLDFSSELSHVKKAAKVNLEQLEKDVKQLERGLKKLERELELSALdEHP 308

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1005261204  948 APALRARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYLGYTPqaaREVRIMQFCHTLREFALEYR 1014
Cdd:pfam02181  309 DDKFREVLKEFLKSAEEKLDKLESLLREALELFKELVEYFGEDP---KETSPEEFFKILRDFLKEFK 372
FH2 smart00498
Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, ...
 647-1085 1.12e-93

Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarisation. Members of this family have been found to interact with Rho-GTPases, profilin and other actin-assoziated proteins. These interactions are mediated by the proline-rich FH1 domain, usually located in front of FH2 (but not listed in SMART). Despite this cytosolic function, vertebrate formins have been assigned functions within the nucleus. A set of Formin-Binding Proteins (FBPs) has been shown to bind FH1 with their WW domain.


Pssm-ID: 214697 [Multi-domain]  Cd Length: 392  Bit Score: 305.81  E-value: 1.12e-93
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204   647 PTKRKTVKLFWRELKLAGghgvsasrfgPCATLWASLDPVS-VDTARLEHLFESRAKEVLPSKKAGEGR-------RTMT 718
Cdd:smart00498    5 KPKKKLKPLHWDKLNPSD----------LSGTVWDKIDEESeGDLDELEELFSAKEKTKSASKDVSEKKsilkkkaSQEF 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204   719 TVLDPKRSNAINIGLTTLP-PVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIEEAQLANPdIPLGPAENFLMTL 797
Cdd:smart00498   75 KILDPKRSQNLAILLRKLHmSYEEIKEAILEGDEDVLSVDLLEQLLKYAPTKEELKKLREYKEEDP-EELARAEQFLLLI 153

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204   798 ASIGGLAARLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNG----SQSSGFELSYLEKV 873
Cdd:smart00498  154 SNIPYLEERLNALLFKANFEEEVEDLKPQIEKVEAACEELRESKKFRKLLELILAIGNYMNGgsrrGQAYGFKLSSLLKL 233

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204   874 SEVKDTVRRQSLLHHLCSLVLQTRpessdlyseipaltrcakvdfeqltenlgqlerrsraaeesLRSLAKHELAP-ALR 952
Cdd:smart00498  234 SDVKSADNKTTLLHFLVKIIRKKY-----------------------------------------LGGLSDPENLDdKFI 272

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204   953 ARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYLGYTPQaarEVRIMQFCHTLREFALEYRTCRErvlQQQQKQATYRE 1032
Cdd:smart00498  273 EVMKPFLKAAKEKYDKLQKDLSDLKTRFEKLVEYYGEDPK---DTSPEEFFKDFNEFLKEFSKAAE---ENIKKEEEEEE 346

                           410       420       430       440       450
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1005261204  1033 RNKTRGRMITETEKFSGVAGEapSNPSVPVAVSsgpgrgdADSHASMKSLLTS 1085
Cdd:smart00498  347 RRKKLVKETTEYEQSSSRQKE--RNPSMDFEVE-------RDFLGVLDSLLEE 390
Formin_GBD_N pfam18382
Formin N-terminal GTPase-binding domain; This is the N-terminal GTPase-binding domain (GBD) of ...
 17-135 9.97e-56

Formin N-terminal GTPase-binding domain; This is the N-terminal GTPase-binding domain (GBD) of formins also known as formin homology domain-containing proteins (FHOD) pfam02181. This GBD is recruited by Rac and Ras GTPases in cells and plays an essential role for FHOD1-mediated actin remodelling and transcriptional activation, localizes to specific GTPases in cells, and binds to GTPases in vitro. It exhibits structural similarity to the ubiquitin superfold as found, for example, in the Ras-binding domains of c-Raf1 or PI3 kinase, but contains an unusual loop that inserts into the first FH3 repeat.


Pssm-ID: 465735  Cd Length: 119  Bit Score: 188.72  E-value: 9.97e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204   17 TVRVQYLEDTDPFAC-ANFPEPRRAPTCSLDGALPLGAQIPAVHRLLGAPLKLEDCALQV---SPSGYYLDTELSLEEQR 92
Cdd:pfam18382    1 TCRVQYLNDTDPFACtSNFPEPTRPPTFTFNEDLPLSEQLAGVHRLLQAPHKLEDCALQVyrdGDYGNYLDLDSSLAEQR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1005261204   93 EMLEGFYEEiskgRKPTLILRTQLSVRVNAILEKLYSSSGPEL 135
Cdd:pfam18382   81 EELEGFQED----RKNSLVLRTQLSVRVHAIIEKLLNSSGREL 119
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 337-553 9.47e-07

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 53.15  E-value: 9.47e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  337 EDGDIEEAPGAGGRRERRKP-SSEEGKRSRRSlegggCPARAPEPG--------PTGPASPVGPTSSTGPALLTGP--AS 405
Cdd:PTZ00449   530 EEGEHEDSKESDEPKEGGKPgETKEGEVGKKP-----GPAKEHKPSkiptlskkPEFPKDPKHPKDPEEPKKPKRPrsAQ 604

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  406 SPVGPPSGLQASVNLFPTISVAPSADTSSERSIYKlHQTASVWAPESPPVPQSP--PGQAR--LEARFLENVAAAETEKq 481
Cdd:PTZ00449   605 RPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPP-QRPSSPERPEGPKIIKSPkpPKSPKppFDPKFKEKFYDDYLDA- 682

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1005261204  482 valAQGRAETLAGAMPNEAGGHPDARQLwdsPETAPAARTPQSPAPCVLLRAQRSLAPEPKEPLIPASPKAE 553
Cdd:PTZ00449   683 ---AAKSKETKTTVVLDESFESILKETL---PETPGTPFTTPRPLPPKLPRDEEFPFEPIGDPDAEQPDDIE 748
 
Name Accession Description Interval E-value
FH2 pfam02181
Formin Homology 2 Domain;
642-1014 2.51e-109

Formin Homology 2 Domain;


Pssm-ID: 396655  Cd Length: 372  Bit Score: 347.34  E-value: 2.51e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  642 DSSALPTKRKTVKLFWRELKLAGGHGvsasrfgpcaTLWASLDPVS----VDTARLEHLFESRAKEVLPSK----KAGEG 713
Cdd:pfam02181    1 PKKTPKPKKKLKPLHWDKVRPSQDRG----------TVWDKLDDESfeldGDLSELEELFSAKAKTKKNKKsedkSSSKK 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  714 RRTMTTVLDPKRSNAINIGLTTL-PPVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIeeAQLANPDIPLGPAEN 792
Cdd:pfam02181   71 KPKEVSLLDPKRAQNIAILLRKLkLPPEEIIQAILEGDEDALDLELLENLLKMAPTKEELKKL--KEYKGDPSELGRAEQ 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  793 FLMTLASIGGLAARLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNGS----QSSGFELS 868
Cdd:pfam02181  149 FLLELSKIPRLEARLRALLFKSTFEEEIEELKPSLEALEAASEELRNSRKFKKLLELILALGNYMNDGtrrgQAKGFKLS 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  869 YLEKVSEVKDTVRRQSLLHHLCSLVLQTRPESSDLYSEIPALTRCAKVDFEQLTENLGQLERRSRAAEESLRSLAK-HEL 947
Cdd:pfam02181  229 SLLKLSDTKSTDNKTTLLHYLVKIIREKFPEVLDFSSELSHVKKAAKVNLEQLEKDVKQLERGLKKLERELELSALdEHP 308

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1005261204  948 APALRARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYLGYTPqaaREVRIMQFCHTLREFALEYR 1014
Cdd:pfam02181  309 DDKFREVLKEFLKSAEEKLDKLESLLREALELFKELVEYFGEDP---KETSPEEFFKILRDFLKEFK 372
FH2 smart00498
Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, ...
 647-1085 1.12e-93

Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarisation. Members of this family have been found to interact with Rho-GTPases, profilin and other actin-assoziated proteins. These interactions are mediated by the proline-rich FH1 domain, usually located in front of FH2 (but not listed in SMART). Despite this cytosolic function, vertebrate formins have been assigned functions within the nucleus. A set of Formin-Binding Proteins (FBPs) has been shown to bind FH1 with their WW domain.


Pssm-ID: 214697 [Multi-domain]  Cd Length: 392  Bit Score: 305.81  E-value: 1.12e-93
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204   647 PTKRKTVKLFWRELKLAGghgvsasrfgPCATLWASLDPVS-VDTARLEHLFESRAKEVLPSKKAGEGR-------RTMT 718
Cdd:smart00498    5 KPKKKLKPLHWDKLNPSD----------LSGTVWDKIDEESeGDLDELEELFSAKEKTKSASKDVSEKKsilkkkaSQEF 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204   719 TVLDPKRSNAINIGLTTLP-PVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIEEAQLANPdIPLGPAENFLMTL 797
Cdd:smart00498   75 KILDPKRSQNLAILLRKLHmSYEEIKEAILEGDEDVLSVDLLEQLLKYAPTKEELKKLREYKEEDP-EELARAEQFLLLI 153

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204   798 ASIGGLAARLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNG----SQSSGFELSYLEKV 873
Cdd:smart00498  154 SNIPYLEERLNALLFKANFEEEVEDLKPQIEKVEAACEELRESKKFRKLLELILAIGNYMNGgsrrGQAYGFKLSSLLKL 233

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204   874 SEVKDTVRRQSLLHHLCSLVLQTRpessdlyseipaltrcakvdfeqltenlgqlerrsraaeesLRSLAKHELAP-ALR 952
Cdd:smart00498  234 SDVKSADNKTTLLHFLVKIIRKKY-----------------------------------------LGGLSDPENLDdKFI 272

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204   953 ARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYLGYTPQaarEVRIMQFCHTLREFALEYRTCRErvlQQQQKQATYRE 1032
Cdd:smart00498  273 EVMKPFLKAAKEKYDKLQKDLSDLKTRFEKLVEYYGEDPK---DTSPEEFFKDFNEFLKEFSKAAE---ENIKKEEEEEE 346

                           410       420       430       440       450
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1005261204  1033 RNKTRGRMITETEKFSGVAGEapSNPSVPVAVSsgpgrgdADSHASMKSLLTS 1085
Cdd:smart00498  347 RRKKLVKETTEYEQSSSRQKE--RNPSMDFEVE-------RDFLGVLDSLLEE 390
Formin_GBD_N pfam18382
Formin N-terminal GTPase-binding domain; This is the N-terminal GTPase-binding domain (GBD) of ...
 17-135 9.97e-56

Formin N-terminal GTPase-binding domain; This is the N-terminal GTPase-binding domain (GBD) of formins also known as formin homology domain-containing proteins (FHOD) pfam02181. This GBD is recruited by Rac and Ras GTPases in cells and plays an essential role for FHOD1-mediated actin remodelling and transcriptional activation, localizes to specific GTPases in cells, and binds to GTPases in vitro. It exhibits structural similarity to the ubiquitin superfold as found, for example, in the Ras-binding domains of c-Raf1 or PI3 kinase, but contains an unusual loop that inserts into the first FH3 repeat.


Pssm-ID: 465735  Cd Length: 119  Bit Score: 188.72  E-value: 9.97e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204   17 TVRVQYLEDTDPFAC-ANFPEPRRAPTCSLDGALPLGAQIPAVHRLLGAPLKLEDCALQV---SPSGYYLDTELSLEEQR 92
Cdd:pfam18382    1 TCRVQYLNDTDPFACtSNFPEPTRPPTFTFNEDLPLSEQLAGVHRLLQAPHKLEDCALQVyrdGDYGNYLDLDSSLAEQR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1005261204   93 EMLEGFYEEiskgRKPTLILRTQLSVRVNAILEKLYSSSGPEL 135
Cdd:pfam18382   81 EELEGFQED----RKNSLVLRTQLSVRVHAIIEKLLNSSGREL 119
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 337-553 9.47e-07

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 53.15  E-value: 9.47e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  337 EDGDIEEAPGAGGRRERRKP-SSEEGKRSRRSlegggCPARAPEPG--------PTGPASPVGPTSSTGPALLTGP--AS 405
Cdd:PTZ00449   530 EEGEHEDSKESDEPKEGGKPgETKEGEVGKKP-----GPAKEHKPSkiptlskkPEFPKDPKHPKDPEEPKKPKRPrsAQ 604

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  406 SPVGPPSGLQASVNLFPTISVAPSADTSSERSIYKlHQTASVWAPESPPVPQSP--PGQAR--LEARFLENVAAAETEKq 481
Cdd:PTZ00449   605 RPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPP-QRPSSPERPEGPKIIKSPkpPKSPKppFDPKFKEKFYDDYLDA- 682

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1005261204  482 valAQGRAETLAGAMPNEAGGHPDARQLwdsPETAPAARTPQSPAPCVLLRAQRSLAPEPKEPLIPASPKAE 553
Cdd:PTZ00449   683 ---AAKSKETKTTVVLDESFESILKETL---PETPGTPFTTPRPLPPKLPRDEEFPFEPIGDPDAEQPDDIE 748
PHA03247 PHA03247
large tegument protein UL36; Provisional
 347-564 3.47e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 3.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  347 AGGRRERRKPSSEEGKRSRRSLEGGGCPARAPEPGPTGPASPVGPTSSTGPAlltgPASSPVGPPSGLQASVNLFPTISV 426
Cdd:PHA03247  2581 AVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPS----PAANEPDPHPPPTVPPPERPRDDP 2656

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  427 APSADTSSERsiyklhqtasVWAPESPPVPQSPPGQARLEArflenvaaaetekqvalaqgrAETLAGAMPNEAGGHPDA 506
Cdd:PHA03247  2657 APGRVSRPRR----------ARRLGRAAQASSPPQRPRRRA---------------------ARPTVGSLTSLADPPPPP 2705

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1005261204  507 RqlwdSPETAPAARTPQSPAPCVLLRAQRSLAPEPKEPLIPASPKAEPIWELPTRAPR 564
Cdd:PHA03247  2706 P----TPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPAR 2759
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
377-554 7.83e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 50.23  E-value: 7.83e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  377 APEPGPTGPASPVGPTSSTGPALLtgPASSPVGPPSGLQASVNLFPTISVAPSAdTSSERSIYKLHQTASVWAPESPPVP 456
Cdd:PRK07003   357 AFEPAVTGGGAPGGGVPARVAGAV--PAPGARAAAAVGASAVPAVTAVTGAAGA-ALAPKAAAAAAATRAEAPPAAPAPP 433

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  457 QS-----------PPGQARLEARFLENVAAAETEKQVALAQGRAETLAGAMPNEAGGHPDARQLWDSPETAPAARTPQSP 525
Cdd:PRK07003   434 ATadrgddaadgdAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAP 513

                          170       180
                   ....*....|....*....|....*....
gi 1005261204  526 APcvllrAQRSLAPEPKEPLIPASPKAEP 554
Cdd:PRK07003   514 AA-----ASREDAPAAAAPPAPEARPPTP 537
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
342-526 4.03e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 47.92  E-value: 4.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  342 EEAPGAGGRRERRKPSSEEGKRSR---RSLEGGGCPARAPEPGPTGPASPVGPTSSTGPALLTGPASSPVGPPSGLQASV 418
Cdd:PRK07003   359 EPAVTGGGAPGGGVPARVAGAVPApgaRAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADR 438

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  419 NLFPTISVAPSADTSSERSIYKLHQTASVWAPESPPVPQS-PPGQARLEARFLENVAAAETEKQVALAQGRAETLAGAMP 497
Cdd:PRK07003   439 GDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASaPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASR 518

                          170       180
                   ....*....|....*....|....*....
gi 1005261204  498 NEAGGHPDARQLWDSPEtAPAARTPQSPA 526
Cdd:PRK07003   519 EDAPAAAAPPAPEARPP-TPAAAAPAARA 546
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 370-583 1.22e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.52  E-value: 1.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  370 GGGCPARAPEPGPTG-------PASPVGPTSSTGPAllTGPASSPVGPPSGLQASVNLFPTISVAPSADTSSERSIYKLH 442
Cdd:PRK07764   593 GAAGGEGPPAPASSGppeeaarPAAPAAPAAPAAPA--PAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWP 670

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  443 QTASVWAPESPPVPQSPPGQArlearflenvAAAETEKQVALAQGRAETLAGAMPNEAGGHPDARQLWDSPETAPAARTP 522
Cdd:PRK07764   671 AKAGGAAPAAPPPAPAPAAPA----------APAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVP 740

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1005261204  523 QSPAP---CVLLRAQRSLAPE--PKEPLIPASPKAEPIWELPTRAPRLSIGDLDFSDLGEDEDQDM 583
Cdd:PRK07764   741 LPPEPddpPDPAGAPAQPPPPpaPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAM 806
PHA03378 PHA03378
EBNA-3B; Provisional
 344-561 1.60e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 46.21  E-value: 1.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  344 APGAGGRRE-RRKPSSEEGKRSRRSL-EGGGCPARAPEPGPTGPASPVGPTSST-GPALLTGPASSPVGPPSGLQASVNL 420
Cdd:PHA03378   589 APSYAQTPWpVPHPSQTPEPPTTQSHiPETSAPRQWPMPLRPIPMRPLRMQPITfNVLVFPTPHQPPQVEITPYKPTWTQ 668

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  421 FPTISVAPS-ADTSSERSIYKLHQTASVWA--------PESPPVPQSPPGQARLEARflENVAAAETEKQVALAQGRAET 491
Cdd:PHA03378   669 IGHIPYQPSpTGANTMLPIQWAPGTMQPPPraptpmrpPAAPPGRAQRPAAATGRAR--PPAAAPGRARPPAAAPGRARP 746

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1005261204  492 LAGAmPNEAGGHPDARQLWDSPETAPAARTPQSP---APCVLLRAQRSLAPEPKEPLIPAS----PKAEPIWELPTR 561
Cdd:PHA03378   747 PAAA-PGRARPPAAAPGRARPPAAAPGAPTPQPPpqaPPAPQQRPRGAPTPQPPPQAGPTSmqlmPRAAPGQQGPTK 822
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
398-571 2.17e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 45.64  E-value: 2.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  398 ALLTGPASSPVGPPSGLQASVNLFPTISVAPSAdtssersiyklhqtasvwAPESPPVPQSPPGQARLEARFLENVAAAE 477
Cdd:PRK12323   362 AFRPGQSGGGAGPATAAAAPVAQPAPAAAAPAA------------------AAPAPAAPPAAPAAAPAAAAAARAVAAAP 423

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  478 TEKQVALaqgraETLAGAMPNEAGGHPDARQLWDSPETAPAARTPQSPAPCVLLRAQRSLAPEPKEPLIPASPKAE--PI 555
Cdd:PRK12323   424 ARRSPAP-----EALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDdpPP 498

                          170
                   ....*....|....*..
gi 1005261204  556 WE-LPTRAPRLSIGDLD 571
Cdd:PRK12323   499 WEeLPPEFASPAPAQPD 515
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 386-563 9.95e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.54  E-value: 9.95e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  386 ASPVGPTSSTGPALLTGPASS-PV---GPPSGLQAsvnlfPTISVAPSADTSSERSIYKLHQTASVwAPESPPVPQSPPG 461
Cdd:PRK10263   334 AAPVEPVTQTPPVASVDVPPAqPTvawQPVPGPQT-----GEPVIAPAPEGYPQQSQYAQPAVQYN-EPLQQPVQPQQPY 407

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  462 QARLEARFLENVAAAETEKQVALAQGRAETLAGAMPNEAGGHPDARQLWDSPETAPAARTPQSPAPcvllRAQRSLAPEP 541
Cdd:PRK10263   408 YAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAA----QEPLYQQPQP 483

                          170       180
                   ....*....|....*....|....
gi 1005261204  542 KEPliPASPKAEPIWE--LPTRAP 563
Cdd:PRK10263   484 VEQ--QPVVEPEPVVEetKPARPP 505
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 377-527 2.40e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.01  E-value: 2.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  377 APEPGPTGPASPVGPTSSTGPALLTGPASSPVGPPSGLQASVNLFPTISVAPSADtssersiyklhQTASVWAPESPPVP 456
Cdd:PRK14951   363 AFKPAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAP-----------PAAAPPAPVAAPAA 431

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1005261204  457 QSPPGQArlearflENVAAAETEKQVALAQGRAETLAGAMPNEAGGHPDARQLWDSPETAPAARTPQSPAP 527
Cdd:PRK14951   432 AAPAAAP-------AAAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEEGD 495
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
365-563 2.95e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 2.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  365 RRSLEGGGCparAPEPGPTGPASPVGPTSSTGPALLTGPASSPVGPPSGLQASVNLFPTISVAPSADTSSERSIYKLHQT 444
Cdd:PRK12323   364 RPGQSGGGA---GPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQAS 440

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  445 ASVWAPESPPVPQSPPgqarlearflenVAAAETEKQVALAQGRAETLAGAMPNEAGGHPDARQLWDSP--ETAPAARTP 522
Cdd:PRK12323   441 ARGPGGAPAPAPAPAA------------APAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPpwEELPPEFAS 508

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1005261204  523 QSPAPCVLLRAQRSLAPEPKEPLIPASPKAEPIWELPTRAP 563
Cdd:PRK12323   509 PAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAP 549
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 348-554 5.79e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.92  E-value: 5.79e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  348 GGRRERRKPSSEEGKRSRRSLEGGGC--PARAPEPGPTGPASPVGPTSSTGPAlLTGPASSPVGPPSGLQASVNLFPTIS 425
Cdd:PHA03307    81 ANESRSTPTWSLSTLAPASPAREGSPtpPGPSSPDPPPPTPPPASPPPSPAPD-LSEMLRPVGSPGPPPAASPPAAGASP 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  426 VAPSADTSSERSIYKLHQ-----TASVWAPESPPVPQSPPGQARLEARFLENVAAAETEKQVALAQGRAETLAGAMPNEA 500
Cdd:PHA03307   160 AAVASDAASSRQAALPLSspeetARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDS 239

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1005261204  501 GGHPDARQLWDSPETAPAARTPQSPAPCVLLRAQRSLAPEPKEPliPASPKAEP 554
Cdd:PHA03307   240 SSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPG--PASSSSSP 291
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
346-566 8.06e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.24  E-value: 8.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  346 GAGGRRERRKPSSEEGKRSRRSLEGGGCPARAPEPGPTGPAS-PVGPTSSTGPAlltgpASSPvgPPSGLQASVNLFPTI 424
Cdd:PRK12323   371 GAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAaAAARAVAAAPA-----RRSP--APEALAAARQASARG 443

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  425 SVAPSADTSSersiyklhqTASVWAPESPPVPQSPPGQARLEARFLENVAAAETEKQVALAQGRAETLAGAMPNEAGGHP 504
Cdd:PRK12323   444 PGGAPAPAPA---------PAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQP 514

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1005261204  505 DA--RQLWDSPETAPAARTPQSPAPcvllraqrSLAPEPKEPLIPAsPKAEPIWELPTRAPRLS 566
Cdd:PRK12323   515 DAapAGWVAESIPDPATADPDDAFE--------TLAPAPAAAPAPR-AAAATEPVVAPRPPRAS 569
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 375-585 9.79e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 39.91  E-value: 9.79e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  375 ARAPEPGPTGPASPVGPTSSTGPALLTGPASSPvGPPSGLQASVNLFPTISVAPSADTSSERSIYKLHQTASVWAPESPP 454
Cdd:PLN03209   336 ADGPKPVPTKPVTPEAPSPPIEEEPPQPKAVVP-RPLSPYTAYEDLKPPTSPIPTPPSSSPASSKSVDAVAKPAEPDVVP 414

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005261204  455 VPQSPPGQARLE--------ARFLENVAAAETEKQVALAQGRAETLAGAMPNEAGGHPdarqlwDSPETAP--AARTPQS 524
Cdd:PLN03209   415 SPGSASNVPEVEpaqveakkTRPLSPYARYEDLKPPTSPSPTAPTGVSPSVSSTSSVP------AVPDTAPatAATDAAA 488

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1005261204  525 PAPCVLLRAQRSLAPEPKEPLIPASPKAEPIWELPTRAPRLSIGDLDFSDLGEDEDQDMLN 585
Cdd:PLN03209   489 PPPANMRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSAPPTALADEQHHAQ 549
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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