NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|972777443|ref|NP_001305447|]
View 

cell division cycle protein 16 homolog isoform 3 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 12124078)

tetratricopeptide repeat (TPR) protein with an ANAPC3 (anaphase-promoting complex, subunit 3) domain, such as human cell division cycle protein 27 homolog and Dictyostelium discoideum anaphase-promoting complex/cyclosome (APC/C) subunit 3

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  16896351|21153002|10517866|30708253
SCOP:  4001344

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANAPC3 pfam12895
Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of ...
 15-93 2.00e-20

Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.


:

Pssm-ID: 463743 [Multi-domain]  Cd Length: 82  Bit Score: 85.77  E-value: 2.00e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443   15 DQQQYQSALFWADKV-ASLSREPQDIYWLAQCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDVLD 93
Cdd:pfam12895   1 DQHQYKNAIFLAERLlAAEPESPEDAYLLAQCLFLNGQYKRAYELLRKAKLNGSSLGCRYLFAQCLLKLKKYDEALDALG 80
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
291-470 8.93e-15

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 74.27  E-value: 8.93e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 291 VDLYPSNPVSWFAVGCYYLMVGhKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGWKTAe 370
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLG-RYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEA- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 371 kwfldalekikaignevtvdkweplLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYF 450
Cdd:COG0457   79 -------------------------LNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAY 133

                        170       180
                 ....*....|....*....|
gi 972777443 451 HTALGLRRDDTFSVTMLGHC 470
Cdd:COG0457  134 ERALELDPDDADALYNLGIA 153
 
Name Accession Description Interval E-value
ANAPC3 pfam12895
Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of ...
 15-93 2.00e-20

Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.


Pssm-ID: 463743 [Multi-domain]  Cd Length: 82  Bit Score: 85.77  E-value: 2.00e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443   15 DQQQYQSALFWADKV-ASLSREPQDIYWLAQCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDVLD 93
Cdd:pfam12895   1 DQHQYKNAIFLAERLlAAEPESPEDAYLLAQCLFLNGQYKRAYELLRKAKLNGSSLGCRYLFAQCLLKLKKYDEALDALG 80
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
291-470 8.93e-15

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 74.27  E-value: 8.93e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 291 VDLYPSNPVSWFAVGCYYLMVGhKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGWKTAe 370
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLG-RYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEA- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 371 kwfldalekikaignevtvdkweplLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYF 450
Cdd:COG0457   79 -------------------------LNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAY 133

                        170       180
                 ....*....|....*....|
gi 972777443 451 HTALGLRRDDTFSVTMLGHC 470
Cdd:COG0457  134 ERALELDPDDADALYNLGIA 153
TPR_12 pfam13424
Tetratricopeptide repeat;
395-459 6.35e-08

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 50.08  E-value: 6.35e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 972777443  395 LLNNLGHVCRKLKKYAEALDYHRQALVLI--------PQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRD 459
Cdd:pfam13424   5 ALNNLAAVLRRLGRYDEALELLEKALEIArrllgpdhPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 133-454 3.31e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 53.55  E-value: 3.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443  133 LLRGKIYDALDNRTLATYSYKEALKLD-----VYCFEAFDLLTSHHMLTAQEEKE-LLESLPLSKLCNEEQELLRFlfen 206
Cdd:TIGR02917 197 LLKGDLLLSLGNIELALAAYRKAIALRpnniaVLLALATILIEAGEFEEAEKHADaLLKKAPNSPLAHYLKALVDF---- 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443  207 KLKKYNKPSETVIpESVDGLQENLDVVVSLAERHYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYL 286
Cdd:TIGR02917 273 QKKNYEDARETLQ-DALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIAT 351

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443  287 SHKLVDLYPSNPVSWFAVGCYYLMVGhKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGW 366
Cdd:TIGR02917 352 LSPALGLDPDDPAALSLLGEAYLALG-DFEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSEAIADLETAAQLDPEL 430

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443  367 KTAEKW----FLDALEKIKAIGnevTVDKWE------PLLNNL-GHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGY 435
Cdd:TIGR02917 431 GRADLLlilsYLRSGQFDKALA---AAKKLEkkqpdnASLHNLlGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLAR 507

                         330
                  ....*....|....*....
gi 972777443  436 IHSLMGNFENAVDYFHTAL 454
Cdd:TIGR02917 508 IDIQEGNPDDAIQRFEKVL 526
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 3-128 3.40e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.54  E-value: 3.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443   3 LERLRKRVRQ--------------YLDQQQYQSALFWADKVASLSRE-PQDIYWLAQCLYLTAQYHRAAHAL-RSRKLDK 66
Cdd:COG4235    3 IARLRQALAAnpndaegwlllgraYLRLGRYDEALAAYEKALRLDPDnADALLDLAEALLAAGDTEEAEELLeRALALDP 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 972777443  67 LYEACRYLAARCHYAAKEHQQALDvldmeepinkrLFEKYLKDEsgfkDPSSDWEMSQSSIK 128
Cdd:COG4235   83 DNPEALYLLGLAAFQQGDYAEAIA-----------AWQKLLALL----PADAPARLLEASIA 129
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 396-426 5.71e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 40.12  E-value: 5.71e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 972777443   396 LNNLGHVCRKLKKYAEALDYHRQALVLIPQN 426
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
PRK02603 PRK02603
photosystem I assembly protein Ycf3; Provisional
 409-456 7.97e-03

photosystem I assembly protein Ycf3; Provisional


Pssm-ID: 179448 [Multi-domain]  Cd Length: 172  Bit Score: 37.73  E-value: 7.97e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 972777443 409 YAEALDYHRQALVLiPQNASTYSAI----GYIHSLMGNFENAVDYFHTALGL 456
Cdd:PRK02603  51 YAEALENYEEALKL-EEDPNDRSYIlynmGIIYASNGEHDKALEYYHQALEL 101
 
Name Accession Description Interval E-value
ANAPC3 pfam12895
Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of ...
 15-93 2.00e-20

Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.


Pssm-ID: 463743 [Multi-domain]  Cd Length: 82  Bit Score: 85.77  E-value: 2.00e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443   15 DQQQYQSALFWADKV-ASLSREPQDIYWLAQCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDVLD 93
Cdd:pfam12895   1 DQHQYKNAIFLAERLlAAEPESPEDAYLLAQCLFLNGQYKRAYELLRKAKLNGSSLGCRYLFAQCLLKLKKYDEALDALG 80
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
291-470 8.93e-15

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 74.27  E-value: 8.93e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 291 VDLYPSNPVSWFAVGCYYLMVGhKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGWKTAe 370
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLG-RYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEA- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 371 kwfldalekikaignevtvdkweplLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYF 450
Cdd:COG0457   79 -------------------------LNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAY 133

                        170       180
                 ....*....|....*....|
gi 972777443 451 HTALGLRRDDTFSVTMLGHC 470
Cdd:COG0457  134 ERALELDPDDADALYNLGIA 153
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 332-481 1.22e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 61.16  E-value: 1.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 332 YGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGWKTAEKWFLDALEKikaignevtVDKWEPLLNNLGHVCRKLKKYAE 411
Cdd:COG3914   94 YEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALAL---------NPDFAEAYLNLGEALRRLGRLEE 164

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 412 ALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIeMYIGDSEAY 481
Cdd:COG3914  165 AIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFAL-RQACDWEVY 233
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 274-440 1.66e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 60.39  E-value: 1.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 274 LVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAM 353
Cdd:COG3914   88 LQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEE-ALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAI 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 354 AAYFTAAQLmkgwktaEKWFLDALekikaignevtvdkwepllNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAi 433
Cdd:COG3914  167 AALRRALEL-------DPDNAEAL-------------------NNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSN- 219


                 ....*..
gi 972777443 434 gYIHSLM 440
Cdd:COG3914  220 -LLFALR 225
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 301-460 3.28e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.50  E-value: 3.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 301 WFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLmkgwktaekwfldaleki 380
Cdd:COG4783    7 LYALAQALLLAGDYDE-AEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALEL------------------ 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 381 kaignevtvDKWEP-LLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRD 459
Cdd:COG4783   68 ---------DPDEPeARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPD 138


                 .
gi 972777443 460 D 460
Cdd:COG4783  139 D 139
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 300-468 3.94e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 54.74  E-value: 3.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 300 SWFAVGCYYLMVGhKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAY---------FTAAQLMKG----- 365
Cdd:COG2956   10 GWYFKGLNYLLNG-QPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHqkllerdpdRAEALLELAqdylk 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 366 ---WKTAEKWFLDALEkikaignevTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGN 442
Cdd:COG2956   89 aglLDRAEELLEKLLE---------LDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGD 159

                        170       180
                 ....*....|....*....|....*.
gi 972777443 443 FENAVDYFHTALGLRRDDTFSVTMLG 468
Cdd:COG2956  160 YDEAIEALEKALKLDPDCARALLLLA 185
TPR_12 pfam13424
Tetratricopeptide repeat;
395-459 6.35e-08

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 50.08  E-value: 6.35e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 972777443  395 LLNNLGHVCRKLKKYAEALDYHRQALVLI--------PQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRD 459
Cdd:pfam13424   5 ALNNLAAVLRRLGRYDEALELLEKALEIArrllgpdhPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 133-454 3.31e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 53.55  E-value: 3.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443  133 LLRGKIYDALDNRTLATYSYKEALKLD-----VYCFEAFDLLTSHHMLTAQEEKE-LLESLPLSKLCNEEQELLRFlfen 206
Cdd:TIGR02917 197 LLKGDLLLSLGNIELALAAYRKAIALRpnniaVLLALATILIEAGEFEEAEKHADaLLKKAPNSPLAHYLKALVDF---- 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443  207 KLKKYNKPSETVIpESVDGLQENLDVVVSLAERHYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYL 286
Cdd:TIGR02917 273 QKKNYEDARETLQ-DALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIAT 351

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443  287 SHKLVDLYPSNPVSWFAVGCYYLMVGhKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGW 366
Cdd:TIGR02917 352 LSPALGLDPDDPAALSLLGEAYLALG-DFEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSEAIADLETAAQLDPEL 430

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443  367 KTAEKW----FLDALEKIKAIGnevTVDKWE------PLLNNL-GHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGY 435
Cdd:TIGR02917 431 GRADLLlilsYLRSGQFDKALA---AAKKLEkkqpdnASLHNLlGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLAR 507

                         330
                  ....*....|....*....
gi 972777443  436 IHSLMGNFENAVDYFHTAL 454
Cdd:TIGR02917 508 IDIQEGNPDDAIQRFEKVL 526
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
359-459 4.20e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 48.24  E-value: 4.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 359 AAQLMKGWKTAEKWFLDALEKIKAIGNevtvdkwepLLNNLGHVCRKLKKYAEALDYhRQALVLIPQNASTYSAIGYIHS 438
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNAD---------ALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAELLL 70

                         90       100
                 ....*....|....*....|.
gi 972777443 439 LMGNFENAVDYFHTALGLRRD 459
Cdd:COG3063   71 ELGDYDEALAYLERALELDPS 91
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 402-468 5.82e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 49.57  E-value: 5.82e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 972777443 402 VCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLG 468
Cdd:COG5010   63 LYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLA 129
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 276-470 6.47e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.27  E-value: 6.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 276 ELNKANELFylsHKLVDLYPSNPVSWFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAA 355
Cdd:COG2956   23 QPDKAIDLL---EEALELDPETVEAHLALGNLYRRRGEYDR-AIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEEL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 356 YFTAAQL-----------------MKGWKTAekwfLDALEKIKAIGnevtvDKWEPLLNNLGHVCRKLKKYAEALDYHRQ 418
Cdd:COG2956   99 LEKLLELdpddaealrllaeiyeqEGDWEKA----IEVLERLLKLG-----PENAHAYCELAELYLEQGDYDEAIEALEK 169

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 972777443 419 ALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHC 470
Cdd:COG2956  170 ALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAEL 221
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 347-470 1.92e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.49  E-value: 1.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 347 SEHDQAMAAYFTAAQLMKGWKTAEKWFLDALEKikaignevtVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQN 426
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALEL---------DPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDE 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 972777443 427 ASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHC 470
Cdd:COG4783   72 PEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARA 115
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 335-470 1.94e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 50.76  E-value: 1.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 335 AWIAYGHSFAVESEHDQAMAAYFTAAQLMKGWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLNN----LGHVCRKLKKYA 410
Cdd:COG3914   16 ALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAAllelAALLLQALGRYE 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 411 EALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHC 470
Cdd:COG3914   96 EALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEA 155
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 3-128 3.40e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.54  E-value: 3.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443   3 LERLRKRVRQ--------------YLDQQQYQSALFWADKVASLSRE-PQDIYWLAQCLYLTAQYHRAAHAL-RSRKLDK 66
Cdd:COG4235    3 IARLRQALAAnpndaegwlllgraYLRLGRYDEALAAYEKALRLDPDnADALLDLAEALLAAGDTEEAEELLeRALALDP 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 972777443  67 LYEACRYLAARCHYAAKEHQQALDvldmeepinkrLFEKYLKDEsgfkDPSSDWEMSQSSIK 128
Cdd:COG4235   83 DNPEALYLLGLAAFQQGDYAEAIA-----------AWQKLLALL----PADAPARLLEASIA 129
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 307-456 4.53e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 46.88  E-value: 4.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 307 YYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGWKTAEKWFLDALEKIKaigne 386
Cdd:COG5010   11 PLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDP----- 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 387 vtvdKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGL 456
Cdd:COG5010   86 ----NNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGT 151
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 289-480 7.16e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.80  E-value: 7.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 289 KLVDLYPSNPVSWFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKG--- 365
Cdd:COG2956   67 KLLERDPDRAEALLELAQDYLKAGLLDR-AEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPEnah 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 366 --------------WKTAEKWFLDALEKIKaignevtvdKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYS 431
Cdd:COG2956  146 aycelaelyleqgdYDEAIEALEKALKLDP---------DCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALP 216

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 972777443 432 AIGYIHSLMGNFENAVDYFHTALGLRRDDTFsVTMLGHCIEMYIGDSEA 480
Cdd:COG2956  217 RLAELYEKLGDPEEALELLRKALELDPSDDL-LLALADLLERKEGLEAA 264
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
395-463 3.44e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 45.29  E-value: 3.44e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 395 LLNNLGHVCRKLKKYAEAL-DYhRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFS 463
Cdd:COG4785   75 LYYERGVAYDSLGDYDLAIaDF-DQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYA 143
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 396-426 5.71e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 40.12  E-value: 5.71e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 972777443   396 LNNLGHVCRKLKKYAEALDYHRQALVLIPQN 426
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR_1 pfam00515
Tetratricopeptide repeat;
396-426 7.58e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 40.10  E-value: 7.58e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 972777443  396 LNNLGHVCRKLKKYAEALDYHRQALVLIPQN 426
Cdd:pfam00515   4 LYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 398-468 8.22e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 42.69  E-value: 8.22e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 972777443 398 NLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLG 468
Cdd:COG4235   22 LLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLG 92
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
289-420 1.26e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.84  E-value: 1.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 289 KLVDLYPSNPVSWFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQL------ 362
Cdd:COG0457   33 KALELDPDDAEALYNLGLAYLRLGRYEE-ALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELdpddae 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 972777443 363 -----------MKGWKTAEKWFLDALEKikaignevtVDKWEPLLNNLGHVCRKLKKYAEALDYHRQAL 420
Cdd:COG0457  112 alynlglalleLGRYDEAIEAYERALEL---------DPDDADALYNLGIALEKLGRYEEALELLEKLE 171
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 308-468 1.94e-04

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 43.09  E-value: 1.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443  308 YLMVGHKnEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLmkGWKTAEkwfldalekikaignev 387
Cdd:TIGR02521  41 YLEQGDL-EVAKENLDKALEHDPDDYLAYLALALYYQQLGELEKAEDSFRRALTL--NPNNGD----------------- 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443  388 tvdkwepLLNNLGHVCRKLKKYAEALDYHRQALV--LIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDdtFSVT 465
Cdd:TIGR02521 101 -------VLNNYGTFLCQQGKYEQAMQQFEQAIEdpLYPQPARSLENAGLCALKAGDFDKAEKYLTRALQIDPQ--RPES 171


                  ...
gi 972777443  466 MLG 468
Cdd:TIGR02521 172 LLE 174
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 335-460 2.56e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 41.14  E-value: 2.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 335 AWIAYGHSFAVESEHDQAMAAYFTAAQLMKgwKTAEkwfldalekikaignevtvdkwepLLNNLGHVCRKLKKYAEALD 414
Cdd:COG4235   19 GWLLLGRAYLRLGRYDEALAAYEKALRLDP--DNAD------------------------ALLDLAEALLAAGDTEEAEE 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 972777443 415 YHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDD 460
Cdd:COG4235   73 LLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPAD 118
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
402-469 2.88e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 40.15  E-value: 2.88e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 972777443 402 VCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDyFHTALGLRRDDTFSVTMLGH 469
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAE 67
TPR_11 pfam13414
TPR repeat;
400-441 8.39e-04

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 37.07  E-value: 8.39e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 972777443  400 GHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMG 441
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKLG 42
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 328-456 1.39e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.61  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443  328 LEKTYGPAWIAYGHSFAVESEHDQAM---AAYFTAAQLMKGWKTAEKW-----------------FLDALEKIKAIGNEV 387
Cdd:TIGR02917 715 RQKDYPAAIQAYRKALKRAPSSQNAIklhRALLASGNTAEAVKTLEAWlkthpndavlrtalaelYLAQKDYDKAIKHYQ 794

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 972777443  388 TVDKWEP----LLNNLGHVCRKLKKyAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGL 456
Cdd:TIGR02917 795 TVVKKAPdnavVLNNLAWLYLELKD-PRALEYAERALKLAPNIPAILDTLGWLLVEKGEADRALPLLRKAVNI 866
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 314-424 1.97e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.17  E-value: 1.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 314 KNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGWKTAekwfldalekikaignevtvdkwe 393
Cdd:COG5010   69 DFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNA------------------------ 124

                         90       100       110
                 ....*....|....*....|....*....|.
gi 972777443 394 plLNNLGHVCRKLKKYAEALDYHRQALVLIP 424
Cdd:COG5010  125 --YSNLAALLLSLGQDDEAKAALQRALGTSP 153
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 2-159 3.57e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 39.71  E-value: 3.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443   2 NLERLRKRVRQYLDQQQYQSALFWADKVASLSREPQDIYW-LAQCLYLTAQYHRAAHAL-RSRKLDKLYEACRYLAARCH 79
Cdd:COG2956  109 DAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCeLAELYLEQGDYDEAIEALeKALKLDPDCARALLLLAELY 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443  80 YAAKEHQQALDVLdmeepinKRLFEkylkdesgfKDPSSdwemsqssikSSICLLRGKIYDALDNRTLATYSYKEALKLD 159
Cdd:COG2956  189 LEQGDYEEAIAAL-------ERALE---------QDPDY----------LPALPRLAELYEKLGDPEEALELLRKALELD 242
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 273-362 3.79e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.86  E-value: 3.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 273 TLVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQA 352
Cdd:COG4783   47 ILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDE-ALALLEKALKLDPEHPEAYLRLARAYRALGRPDEA 125

                         90
                 ....*....|
gi 972777443 353 MAAYFTAAQL 362
Cdd:COG4783  126 IAALEKALEL 135
TPR_7 pfam13176
Tetratricopeptide repeat;
395-422 5.34e-03

Tetratricopeptide repeat;


Pssm-ID: 433012 [Multi-domain]  Cd Length: 36  Bit Score: 34.82  E-value: 5.34e-03
                          10        20
                  ....*....|....*....|....*...
gi 972777443  395 LLNNLGHVCRKLKKYAEALDYHRQALVL 422
Cdd:pfam13176   1 ALLNLGRIYRKLGDYDEAISLYEQALAL 28
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
13-93 7.00e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 36.30  E-value: 7.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443  13 YLDQQQYQSALFWADKVASLSREPQDIY-WLAQCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDV 91
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALELDPDNADALnNLGLLLLEQGRYDEAIALEKALKLDPNNAEALLNLAELLLELGDYDEALAY 81


                 ..
gi 972777443  92 LD 93
Cdd:COG3063   82 LE 83
PRK02603 PRK02603
photosystem I assembly protein Ycf3; Provisional
 409-456 7.97e-03

photosystem I assembly protein Ycf3; Provisional


Pssm-ID: 179448 [Multi-domain]  Cd Length: 172  Bit Score: 37.73  E-value: 7.97e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 972777443 409 YAEALDYHRQALVLiPQNASTYSAI----GYIHSLMGNFENAVDYFHTALGL 456
Cdd:PRK02603  51 YAEALENYEEALKL-EEDPNDRSYIlynmGIIYASNGEHDKALEYYHQALEL 101
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
396-460 8.48e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 37.97  E-value: 8.48e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 972777443 396 LNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDD 460
Cdd:COG4785  110 YNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPND 174
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 295-427 8.80e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.91  E-value: 8.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777443 295 PSNPVSWFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLmkgwktaEKWFL 374
Cdd:COG4235   14 PNDAEGWLLLGRAYLRLGRYDE-ALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL-------DPDNP 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 972777443 375 DALEkikaignevtvdkwepllnNLGHVCRKLKKYAEALDYHRQALVLIPQNA 427
Cdd:COG4235   86 EALY-------------------LLGLAAFQQGDYAEAIAAWQKLLALLPADA 119
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 427-460 9.98e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 33.96  E-value: 9.98e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 972777443   427 ASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDD 460
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH