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Conserved domains on  [gi|973185969|ref|NP_001305636|]
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regulator of MON1-CCZ1 complex isoform 3 [Homo sapiens]

Protein Classification

Mic1 family protein( domain architecture ID 10537131)

Mic1 family protein similar to Homo sapiens regulator of MON1-CCZ1 complex, which is a componement of the CCZ1-MON1 RAB7A guanine exchange factor (GEF) and acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization

Gene Ontology:  GO:0010506|GO:0006914|GO:0035658

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Mic1 pfam07035
Colon cancer-associated protein Mic1-like; This family represents the C-terminus ...
318-475 7.06e-82

Colon cancer-associated protein Mic1-like; This family represents the C-terminus (approximately 160 residues) of a number of proteins that resemble colon cancer-associated protein Mic1.


:

Pssm-ID: 429257  Cd Length: 157  Bit Score: 251.00  E-value: 7.06e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973185969  318 PHKFVIAVLMEYIRSLNQFQIAVQHYLHELVIKTLVQHNLFYMLHQFLQYHVLSDSKPLACLLLSLESFYPPAHQLSLDM 397
Cdd:pfam07035   1 DSSYLVAVLMEYLRSLSKYEIPVQHYLYELLINLLVRNKRFYQLHQFVQYHVLTDSKPLACLLLSLENVYPPAFQLALDM 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 973185969  398 LKRLStANDEIVEVLLSKHQVLAALRFIRGIGGHDNISARKFLDAAKQTEDNMLFYTIFRFFEQRNQRLRGSPNFTPG 475
Cdd:pfam07035  81 LKRLS-AHEEIIEVLLSKGQVLSALRFARSAGGVDSVSARKFLEAAQATNDDMLFYSVYKFFEERNLRLRGSPSFLKG 157
 
Name Accession Description Interval E-value
Mic1 pfam07035
Colon cancer-associated protein Mic1-like; This family represents the C-terminus ...
318-475 7.06e-82

Colon cancer-associated protein Mic1-like; This family represents the C-terminus (approximately 160 residues) of a number of proteins that resemble colon cancer-associated protein Mic1.


Pssm-ID: 429257  Cd Length: 157  Bit Score: 251.00  E-value: 7.06e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973185969  318 PHKFVIAVLMEYIRSLNQFQIAVQHYLHELVIKTLVQHNLFYMLHQFLQYHVLSDSKPLACLLLSLESFYPPAHQLSLDM 397
Cdd:pfam07035   1 DSSYLVAVLMEYLRSLSKYEIPVQHYLYELLINLLVRNKRFYQLHQFVQYHVLTDSKPLACLLLSLENVYPPAFQLALDM 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 973185969  398 LKRLStANDEIVEVLLSKHQVLAALRFIRGIGGHDNISARKFLDAAKQTEDNMLFYTIFRFFEQRNQRLRGSPNFTPG 475
Cdd:pfam07035  81 LKRLS-AHEEIIEVLLSKGQVLSALRFARSAGGVDSVSARKFLEAAQATNDDMLFYSVYKFFEERNLRLRGSPSFLKG 157
 
Name Accession Description Interval E-value
Mic1 pfam07035
Colon cancer-associated protein Mic1-like; This family represents the C-terminus ...
318-475 7.06e-82

Colon cancer-associated protein Mic1-like; This family represents the C-terminus (approximately 160 residues) of a number of proteins that resemble colon cancer-associated protein Mic1.


Pssm-ID: 429257  Cd Length: 157  Bit Score: 251.00  E-value: 7.06e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973185969  318 PHKFVIAVLMEYIRSLNQFQIAVQHYLHELVIKTLVQHNLFYMLHQFLQYHVLSDSKPLACLLLSLESFYPPAHQLSLDM 397
Cdd:pfam07035   1 DSSYLVAVLMEYLRSLSKYEIPVQHYLYELLINLLVRNKRFYQLHQFVQYHVLTDSKPLACLLLSLENVYPPAFQLALDM 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 973185969  398 LKRLStANDEIVEVLLSKHQVLAALRFIRGIGGHDNISARKFLDAAKQTEDNMLFYTIFRFFEQRNQRLRGSPNFTPG 475
Cdd:pfam07035  81 LKRLS-AHEEIIEVLLSKGQVLSALRFARSAGGVDSVSARKFLEAAQATNDDMLFYSVYKFFEERNLRLRGSPSFLKG 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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