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Conserved domains on  [gi|974005295|ref|NP_001305716|]
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toll-like receptor 2 precursor [Homo sapiens]

Protein Classification

toll-like receptor( domain architecture ID 11471523)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
640-784 1.06e-40

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 145.93  E-value: 1.06e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295   640 CYDAFVSYSERDayWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDF 719
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 974005295   720 SHFRLFDENNDAAILILLEPIeKKAIPQRFCKLRKIMnTKTYLEWPMDEAQRegFWVNLRAAIKS 784
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVI-PSDVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPS 139
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-296 1.99e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 1.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295  39 SSGSLNSIPSGLTE--AVKSLDLSNNRITYISNSdLQRCVNLQALVLTSNGINTIEEdSFSSLGSLEHLDLSYNYLSNLS 116
Cdd:COG4886  144 SNNQLTDLPEPLGNltNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLP 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 117 SSwFKPLSSLTFLNLLGNPYKTLGEtslFSHLTKLQILRVGNmdtfTKIQR-KDFAGLTFLEELEIDASDLQSYEPKSLK 195
Cdd:COG4886  222 EP-LANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSN----NQLTDlPPLANLTNLKTLDLSNNQLTDLKLKELE 293

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 196 SIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQ 275
Cdd:COG4886  294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373

                        250       260
                 ....*....|....*....|.
gi 974005295 276 ISGLLELEFDDCTLNGVGNFR 296
Cdd:COG4886  374 LLEATLLTLALLLLTLLLLLL 394
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
221-556 4.71e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.97  E-value: 4.71e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 221 TSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDN 300
Cdd:COG4886    6 LSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 301 DrvIDPGKVETLT-IRRLHIPRFYLFYDLSTLYSLTERVKRITVenskvflVPCLLSQhLKSLEYLDLSENLM--VEEYL 377
Cdd:COG4886   86 L--LGLTDLGDLTnLTELDLSGNEELSNLTNLESLDLSGNQLTD-------LPEELAN-LTNLKELDLSNNQLtdLPEPL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 378 KNsacedaWPSLQTLILRQNHLASLektGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIP- 456
Cdd:COG4886  156 GN------LTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLAn 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 457 -KTLEILDVS--NNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGN 533
Cdd:COG4886  227 lTNLETLDLSnnQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306

                        330       340
                 ....*....|....*....|...
gi 974005295 534 NFICSCEFLSFTQEQQALAKVLI 556
Cdd:COG4886  307 LLNLLELLILLLLLTTLLLLLLL 329
LRRCT smart00082
Leucine rich repeat C-terminal domain;
533-586 1.70e-07

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.20  E-value: 1.70e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 974005295   533 NNFICSCEFLSFTQEQQalAKVLIDWPANYLCDSPSHVRGQQVQDVRlSVSECH 586
Cdd:smart00082   1 NPFICDCELRWLLRWLQ--ANEHLQDPVDLRCASPSSLRGPLLELLH-SEFKCP 51
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
640-784 1.06e-40

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 145.93  E-value: 1.06e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295   640 CYDAFVSYSERDayWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDF 719
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 974005295   720 SHFRLFDENNDAAILILLEPIeKKAIPQRFCKLRKIMnTKTYLEWPMDEAQRegFWVNLRAAIKS 784
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVI-PSDVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPS 139
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 641-767 4.09e-18

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 82.41  E-value: 4.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295  641 YDAFVSYSERDAywVENLMVQELENFN-PPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDF 719
Cdd:pfam01582   1 YDVFLSFRGSDT--REWFVSHLLKELKqKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVK 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 974005295  720 S-HFRLfdENNDAAILILLEPIE------KKAIPQRFCKLRKIMNTKTYLEWPMD 767
Cdd:pfam01582  79 IlECAL--DLGQKVIPIFYEVDPsdvrkqTGSFGKAFKKHKKVLTEEKVLKWRGA 131
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-296 1.99e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 1.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295  39 SSGSLNSIPSGLTE--AVKSLDLSNNRITYISNSdLQRCVNLQALVLTSNGINTIEEdSFSSLGSLEHLDLSYNYLSNLS 116
Cdd:COG4886  144 SNNQLTDLPEPLGNltNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLP 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 117 SSwFKPLSSLTFLNLLGNPYKTLGEtslFSHLTKLQILRVGNmdtfTKIQR-KDFAGLTFLEELEIDASDLQSYEPKSLK 195
Cdd:COG4886  222 EP-LANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSN----NQLTDlPPLANLTNLKTLDLSNNQLTDLKLKELE 293

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 196 SIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQ 275
Cdd:COG4886  294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373

                        250       260
                 ....*....|....*....|.
gi 974005295 276 ISGLLELEFDDCTLNGVGNFR 296
Cdd:COG4886  374 LLEATLLTLALLLLTLLLLLL 394
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
221-556 4.71e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.97  E-value: 4.71e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 221 TSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDN 300
Cdd:COG4886    6 LSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 301 DrvIDPGKVETLT-IRRLHIPRFYLFYDLSTLYSLTERVKRITVenskvflVPCLLSQhLKSLEYLDLSENLM--VEEYL 377
Cdd:COG4886   86 L--LGLTDLGDLTnLTELDLSGNEELSNLTNLESLDLSGNQLTD-------LPEELAN-LTNLKELDLSNNQLtdLPEPL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 378 KNsacedaWPSLQTLILRQNHLASLektGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIP- 456
Cdd:COG4886  156 GN------LTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLAn 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 457 -KTLEILDVS--NNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGN 533
Cdd:COG4886  227 lTNLETLDLSnnQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306

                        330       340
                 ....*....|....*....|...
gi 974005295 534 NFICSCEFLSFTQEQQALAKVLI 556
Cdd:COG4886  307 LLNLLELLILLLLLTTLLLLLLL 329
LRR_8 pfam13855
Leucine rich repeat;
77-135 6.46e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 6.46e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 974005295   77 NLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNP 135
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
324-558 7.43e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 59.33  E-value: 7.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 324 LFYDLSTLYSLTER----VKRITVENSKVFLVPCLLSQhlkSLEYLDLSENLMVE--EYLknsacedawPS-LQTLILRQ 396
Cdd:PRK15370 204 LILDNNELKSLPENlqgnIKTLYANSNQLTSIPATLPD---TIQEMELSINRITElpERL---------PSaLQSLDLFH 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 397 NHLASLEKTgetllTLKNLTNIDISKNSFHSMPEtcQWPEKMKYLNLSStriHSVTGcIPKTLEildvsnnnlnlfslnl 476
Cdd:PRK15370 272 NKISCLPEN-----LPEELRYLSVYDNSIRTLPA--HLPSGITHLNVQS---NSLTA-LPETLP---------------- 324

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 477 PQLKELYISRNKLMTLPdASLLPMLLVLKISRNAITTFSK------EQLDSFH------------TLKTLEAGGNNFICS 538
Cdd:PRK15370 325 PGLKTLEAGENALTSLP-ASLPPELQVLDVSKNQITVLPEtlpptiTTLDVSRnaltnlpenlpaALQIMQASRNNLVRL 403

                        250       260
                 ....*....|....*....|.
gi 974005295 539 CEFL-SFTQEQQALAKVLIDW 558
Cdd:PRK15370 404 PESLpHFRGEGPQPTRIIVEY 424
LRRCT smart00082
Leucine rich repeat C-terminal domain;
533-586 1.70e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.20  E-value: 1.70e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 974005295   533 NNFICSCEFLSFTQEQQalAKVLIDWPANYLCDSPSHVRGQQVQDVRlSVSECH 586
Cdd:smart00082   1 NPFICDCELRWLLRWLQ--ANEHLQDPVDLRCASPSSLRGPLLELLH-SEFKCP 51
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 57-209 2.56e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.01  E-value: 2.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295  57 LDLSNNRITYISNsdLQRCVNLQALVLTSNGINTIEedSFSSLGSLEHLDLSYNYLS---NLSSswfkpLSSLTFLNL-- 131
Cdd:cd21340   29 LYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISvveGLEN-----LTNLEELHIen 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 132 ----LGNPYkTLGETSLFSHLTKLQILRVGNmdtfTKIQR-KDFAGLTFLEELeiDASDLQsyepksLKSIQNVSHLILH 206
Cdd:cd21340  100 qrlpPGEKL-TFDPRSLAALSNSLRVLNISG----NNIDSlEPLAPLRNLEQL--DASNNQ------ISDLEELLDLLSS 166


                 ...
gi 974005295 207 MKQ 209
Cdd:cd21340  167 WPS 169
PLN03150 PLN03150
hypothetical protein; Provisional
 54-134 1.85e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 48.27  E-value: 1.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295  54 VKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLG 133
Cdd:PLN03150 420 IDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNG 499


                 .
gi 974005295 134 N 134
Cdd:PLN03150 500 N 500
LRR_8 pfam13855
Leucine rich repeat;
477-535 4.82e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 4.82e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 974005295  477 PQLKELYISRNKLMTLPDASL--LPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNF 535
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT pfam01463
Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 561-586 3.96e-03

Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.


Pssm-ID: 279765  Cd Length: 26  Bit Score: 35.49  E-value: 3.96e-03
                          10        20
                  ....*....|....*....|....*.
gi 974005295  561 NYLCDSPSHVRGQQVQDVRLSVSECH 586
Cdd:pfam01463   1 NARCASPPRLRGQPLLDLLPSDFSCS 26
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
640-784 1.06e-40

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 145.93  E-value: 1.06e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295   640 CYDAFVSYSERDayWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDF 719
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 974005295   720 SHFRLFDENNDAAILILLEPIeKKAIPQRFCKLRKIMnTKTYLEWPMDEAQRegFWVNLRAAIKS 784
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVI-PSDVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPS 139
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 641-767 4.09e-18

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 82.41  E-value: 4.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295  641 YDAFVSYSERDAywVENLMVQELENFN-PPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDF 719
Cdd:pfam01582   1 YDVFLSFRGSDT--REWFVSHLLKELKqKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVK 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 974005295  720 S-HFRLfdENNDAAILILLEPIE------KKAIPQRFCKLRKIMNTKTYLEWPMD 767
Cdd:pfam01582  79 IlECAL--DLGQKVIPIFYEVDPsdvrkqTGSFGKAFKKHKKVLTEEKVLKWRGA 131
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-296 1.99e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 1.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295  39 SSGSLNSIPSGLTE--AVKSLDLSNNRITYISNSdLQRCVNLQALVLTSNGINTIEEdSFSSLGSLEHLDLSYNYLSNLS 116
Cdd:COG4886  144 SNNQLTDLPEPLGNltNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLP 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 117 SSwFKPLSSLTFLNLLGNPYKTLGEtslFSHLTKLQILRVGNmdtfTKIQR-KDFAGLTFLEELEIDASDLQSYEPKSLK 195
Cdd:COG4886  222 EP-LANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSN----NQLTDlPPLANLTNLKTLDLSNNQLTDLKLKELE 293

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 196 SIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQ 275
Cdd:COG4886  294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373

                        250       260
                 ....*....|....*....|.
gi 974005295 276 ISGLLELEFDDCTLNGVGNFR 296
Cdd:COG4886  374 LLEATLLTLALLLLTLLLLLL 394
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-334 3.36e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.36  E-value: 3.36e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295  39 SSGSLNSIPSGLTE--AVKSLDLSNNRITYISnSDLQRCVNLQALVLTSNGINTIEEdSFSSLGSLEHLDLSYNYLSNLS 116
Cdd:COG4886  121 SGNQLTDLPEELANltNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 117 SSwFKPLSSLTFLNLLGNPYKTLGETslFSHLTKLQILRVGNmdtfTKIQR-KDFAGLTFLEELEIDASDLQSYEPksLK 195
Cdd:COG4886  199 EP-LGNLTNLEELDLSGNQLTDLPEP--LANLTNLETLDLSN----NQLTDlPELGNLTNLEELDLSNNQLTDLPP--LA 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 196 SIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQ 275
Cdd:COG4886  270 NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLAL 349

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 974005295 276 ISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSL 334
Cdd:COG4886  350 LTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALL 408
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
221-556 4.71e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.97  E-value: 4.71e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 221 TSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDN 300
Cdd:COG4886    6 LSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 301 DrvIDPGKVETLT-IRRLHIPRFYLFYDLSTLYSLTERVKRITVenskvflVPCLLSQhLKSLEYLDLSENLM--VEEYL 377
Cdd:COG4886   86 L--LGLTDLGDLTnLTELDLSGNEELSNLTNLESLDLSGNQLTD-------LPEELAN-LTNLKELDLSNNQLtdLPEPL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 378 KNsacedaWPSLQTLILRQNHLASLektGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIP- 456
Cdd:COG4886  156 GN------LTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLAn 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 457 -KTLEILDVS--NNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGN 533
Cdd:COG4886  227 lTNLETLDLSnnQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306

                        330       340
                 ....*....|....*....|...
gi 974005295 534 NFICSCEFLSFTQEQQALAKVLI 556
Cdd:COG4886  307 LLNLLELLILLLLLTTLLLLLLL 329
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 644-718 1.18e-13

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 68.11  E-value: 1.18e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 974005295  644 FVSYSERDAYWVENLmVQELENFNppFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELD 718
Cdd:pfam13676   2 FISYAGEDRAWAEWL-ADALEAAG--YRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWE 73
LRR_8 pfam13855
Leucine rich repeat;
77-135 6.46e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 6.46e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 974005295   77 NLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNP 135
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
54-112 8.65e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 8.65e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 974005295   54 VKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYL 112
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
324-558 7.43e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 59.33  E-value: 7.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 324 LFYDLSTLYSLTER----VKRITVENSKVFLVPCLLSQhlkSLEYLDLSENLMVE--EYLknsacedawPS-LQTLILRQ 396
Cdd:PRK15370 204 LILDNNELKSLPENlqgnIKTLYANSNQLTSIPATLPD---TIQEMELSINRITElpERL---------PSaLQSLDLFH 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 397 NHLASLEKTgetllTLKNLTNIDISKNSFHSMPEtcQWPEKMKYLNLSStriHSVTGcIPKTLEildvsnnnlnlfslnl 476
Cdd:PRK15370 272 NKISCLPEN-----LPEELRYLSVYDNSIRTLPA--HLPSGITHLNVQS---NSLTA-LPETLP---------------- 324

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 477 PQLKELYISRNKLMTLPdASLLPMLLVLKISRNAITTFSK------EQLDSFH------------TLKTLEAGGNNFICS 538
Cdd:PRK15370 325 PGLKTLEAGENALTSLP-ASLPPELQVLDVSKNQITVLPEtlpptiTTLDVSRnaltnlpenlpaALQIMQASRNNLVRL 403

                        250       260
                 ....*....|....*....|.
gi 974005295 539 CEFL-SFTQEQQALAKVLIDW 558
Cdd:PRK15370 404 PESLpHFRGEGPQPTRIIVEY 424
LRRCT smart00082
Leucine rich repeat C-terminal domain;
533-586 1.70e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.20  E-value: 1.70e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 974005295   533 NNFICSCEFLSFTQEQQalAKVLIDWPANYLCDSPSHVRGQQVQDVRlSVSECH 586
Cdd:smart00082   1 NPFICDCELRWLLRWLQ--ANEHLQDPVDLRCASPSSLRGPLLELLH-SEFKCP 51
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
359-555 1.62e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.09  E-value: 1.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 359 LKSLEYLDLSENLMVE--EYLKNsacedaWPSLQTLILRQNHLASLektGETLLTLKNLTNIDISKNSFHSMPETCQWPe 436
Cdd:COG4886  181 LTNLKELDLSNNQITDlpEPLGN------LTNLEELDLSGNQLTDL---PEPLANLTNLETLDLSNNQLTDLPELGNLT- 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 437 KMKYLNLSSTRIHSvtgcIPKTLEIldvsnnnlnlfslnlPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSK 516
Cdd:COG4886  251 NLEELDLSNNQLTD----LPPLANL---------------TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 974005295 517 EQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVL 555
Cdd:COG4886  312 ELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 57-209 2.56e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.01  E-value: 2.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295  57 LDLSNNRITYISNsdLQRCVNLQALVLTSNGINTIEedSFSSLGSLEHLDLSYNYLS---NLSSswfkpLSSLTFLNL-- 131
Cdd:cd21340   29 LYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISvveGLEN-----LTNLEELHIen 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 132 ----LGNPYkTLGETSLFSHLTKLQILRVGNmdtfTKIQR-KDFAGLTFLEELeiDASDLQsyepksLKSIQNVSHLILH 206
Cdd:cd21340  100 qrlpPGEKL-TFDPRSLAALSNSLRVLNISG----NNIDSlEPLAPLRNLEQL--DASNNQ------ISDLEELLDLLSS 166


                 ...
gi 974005295 207 MKQ 209
Cdd:cd21340  167 WPS 169
PLN03150 PLN03150
hypothetical protein; Provisional
 54-134 1.85e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 48.27  E-value: 1.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295  54 VKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLG 133
Cdd:PLN03150 420 IDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNG 499


                 .
gi 974005295 134 N 134
Cdd:PLN03150 500 N 500
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 57-199 3.86e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 3.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295  57 LDLSNNRITYISNsdLQRCVNLQALVLTSNGINTIEedSFSSLGSLEHLDLSYNYLS---NLSSswfkpLSSLTFLNLLG 133
Cdd:cd21340    7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEkieNLEN-----LVNLKKLYLGG 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 974005295 134 NpyktlgetslfshltklQILRVGNMDtftkiqrkdfaGLTFLEELEIDASDLQS-----YEPKSLKSIQN 199
Cdd:cd21340   78 N-----------------RISVVEGLE-----------NLTNLEELHIENQRLPPgekltFDPRSLAALSN 120
LRR_8 pfam13855
Leucine rich repeat;
477-535 4.82e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 4.82e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 974005295  477 PQLKELYISRNKLMTLPDASL--LPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNF 535
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 57-135 5.09e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.16  E-value: 5.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295  57 LDLSNNRITYISNsdLQRCVNLQAL----------------------------VLT--SNGINTIEEdsFSSLGSLEHLD 106
Cdd:cd21340   73 LYLGGNRISVVEG--LENLTNLEELhienqrlppgekltfdprslaalsnslrVLNisGNNIDSLEP--LAPLRNLEQLD 148

                         90       100       110
                 ....*....|....*....|....*....|.
gi 974005295 107 LSYNYLSNLS--SSWFKPLSSLTFLNLLGNP 135
Cdd:cd21340  149 ASNNQISDLEelLDLLSSWPSLRELDLTGNP 179
LRR_9 pfam14580
Leucine-rich repeat;
54-169 2.75e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 42.44  E-value: 2.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295   54 VKSLDLSNNRITYISNSDLQRCVNLQALVLTSNgintieedSFSSLGSLEHLdlsynylsnlssswfKPLSSLTFLNLLG 133
Cdd:pfam14580  66 LKTLLLNNNRICRIGEGLGEALPNLTELILTNN--------NLQELGDLDPL---------------ASLKKLTFLSLLR 122

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 974005295  134 NPYKTLGETSLFShLTKLQILRVGNmdtFTKIQRKD 169
Cdd:pfam14580 123 NPVTNKPHYRLYV-IYKVPQLRLLD---FRKVKQKE 154
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
387-533 4.49e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.00  E-value: 4.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 387 PSLQTLILRQNHLASLEKTGETLLTL--------------KNLTNIDISKNSFHSMPETcqwPEKMKYLNLSSTRIHSVT 452
Cdd:PRK15387 302 PGLQELSVSDNQLASLPALPSELCKLwaynnqltslptlpSGLQELSVSDNQLASLPTL---PSELYKLWAYNNRLTSLP 378

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 453 GcIPKTLEILDVSNNNLNLFSLNLPQLKELYISRNKLMTLPdasLLPM-LLVLKISRNAITTFSkEQLDSFHTLKTLEAG 531
Cdd:PRK15387 379 A-LPSGLKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLP---MLPSgLLSLSVYRNQLTRLP-ESLIHLSSETTVNLE 453


                 ..
gi 974005295 532 GN 533
Cdd:PRK15387 454 GN 455
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 49-110 5.52e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 5.52e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 974005295  49 GLTEAVKSLDLSNNRITYIsnSDLQRCVNLQALVLTSNGINTIEE--DSFSSLGSLEHLDLSYN 110
Cdd:cd21340  117 ALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 40-206 7.05e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.30  E-value: 7.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295  40 SGSLnsiPSGLTEA--VKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSlGSLEHLDLSYNYLSNLSS 117
Cdd:PLN00113 417 SGEL---PSEFTKLplVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVP 492

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295 118 SWFKPLSSLTFLNLLGNpyKTLGET-SLFSHLTKLQILRVGNmDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKS 196
Cdd:PLN00113 493 RKLGSLSELMQLKLSEN--KLSGEIpDELSSCKKLVSLDLSH-NQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGN 569

                        170
                 ....*....|....*
gi 974005295 197 IQ-----NVSHLILH 206
Cdd:PLN00113 570 VEslvqvNISHNHLH 584
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 22-113 1.75e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 1.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005295  22 SSNQASLSCDRNGICKGSSGSLNSIPSglteaVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGS 101
Cdd:PLN00113 474 SKRLENLDLSRNQFSGAVPRKLGSLSE-----LMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPV 548

                         90
                 ....*....|..
gi 974005295 102 LEHLDLSYNYLS 113
Cdd:PLN00113 549 LSQLDLSQNQLS 560
LRR_8 pfam13855
Leucine rich repeat;
387-448 3.92e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 3.92e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 974005295  387 PSLQTLILRQNHLASLEKtgETLLTLKNLTNIDISKNSFHSM-PETCQWPEKMKYLNLSSTRI 448
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDD--GAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRRCT pfam01463
Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 561-586 3.96e-03

Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.


Pssm-ID: 279765  Cd Length: 26  Bit Score: 35.49  E-value: 3.96e-03
                          10        20
                  ....*....|....*....|....*.
gi 974005295  561 NYLCDSPSHVRGQQVQDVRLSVSECH 586
Cdd:pfam01463   1 NARCASPPRLRGQPLLDLLPSDFSCS 26
LRR_8 pfam13855
Leucine rich repeat;
39-88 5.11e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 5.11e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 974005295   39 SSGSLNSIPSGL---TEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGI 88
Cdd:pfam13855   9 SNNRLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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