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Conserved domains on  [gi|987437912|ref|NP_001306913|]
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Fanconi anemia group D2 protein isoform b [Homo sapiens]

Protein Classification

fanconi anemia group D2 protein( domain architecture ID 11235073)

fanconi anemia group D2 protein (FANCD2) is required for maintenance of chromosomal stability, promotion of accurate and efficient pairing of homologs during meiosis, and the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing

Gene Ontology:  GO:0006281|GO:0031573|GO:1990918|GO:0070182

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FancD2 pfam14631
Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease ...
 35-1415 0e+00

Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.


:

Pssm-ID: 464225  Cd Length: 1346  Bit Score: 2493.08  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912    35 SHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHPSYPKIIEEFVSGLESYIEDEDSFRNCL 114
Cdd:pfam14631    1 SHAQNEVEENGSVFVKLLKTAGVILKTGENQNEIAVDQVIFQKKLQQALRKHPSYPKVIEEFITGLESYIEDRDTFRNCL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   115 LSCERLQDEEA-SMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIVSQLKWLDRVVDGKDLT 193
Cdd:pfam14631   81 LPCVPLQSEEAsSMVTSYQESLIKLLLGIEILQPAIIKTLFEKLPEFMFESVNSDGLNMPRLIINQLKWLDRIVDGKDLT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   194 TKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVMDKLSSI 273
Cdd:pfam14631  161 SKLMQLISVAPVELQHDIITSLPEILEDSQHNDVARELSSLLVENTQLTVPILDALSSLNLDPTLLSEVRQAVMGTLSAV 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   274 RLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSA 353
Cdd:pfam14631  241 QLEDLPVVVKFILHSVSATDAYEVISELRKKLDLEQCVLPPVLQASQSKLKSKGAASSSGNQASSSQDCISLVFDVIKSA 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   354 IRYEKTISEAWIKAIENTASVSEHKVFDLVMLFIIYSTNTQTKKYIDRVLRNKIRSGCIQEQLLQSTFSVHYLVLKDMCS 433
Cdd:pfam14631  321 VRFQKTISEAWLKAIENIDSVSDHKVLDLLMLFIIYSTNANQKKGIERVLRNKVRSGCIQEQLLQSTFRTHALVLRDYFP 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   434 SILSLAQSLLHSLDQSIISFGSLLYKYAFKFFDTYCQQEVVGALVTHICSGNEAEVDTALDVLLELVVLNPSAMMMNAVF 513
Cdd:pfam14631  401 SILALAQSLLHSPDQSIVSFGSHMYKYAFTAFDSYCQQEVVGALVTHVCSGNEAEVDVALELLLELVVLKPSAMRLYAVF 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   514 VKGILDYLDNISPQQIRKLFYVLSTLAFSKQNEASSHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAADRSESp 593
Cdd:pfam14631  481 VKGILDYMDNLTPQQIRKLFHILSTLAFSQQHEQSSHIQDDMHIVIRKQLSSTVPKYKRIGIIGAVTMVGSMAADRSKS- 559

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   594 SLTQERANLSDEQCTQVTSLLQLVHSCSEQSPQASALYYDEFANLIQHEKLDPKALEWVGHTICNDFQDAFVVDSCVVPE 673
Cdd:pfam14631  560 GSSSQSASLSKEQCRQVTSLLELVHSCSEQSPQAAALYYDELANLIQKGKLDPKVLEWIGQSVLNDFQDDFVVDLGPDIE 639

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   674 GDFPFPVKALYGLEEYDTQDGIAINLLPLLFSQDFAKDGGPVTSQESGQKLVSPLCLAPYFRLLRLCVERQHNGNLEEID 753
Cdd:pfam14631  640 GDFPFPVKALYGLEEEESQGGIAINLLPLLAKDEQAKDEGEVTAQEKGQKRVSPLCLSPFFRLLRLCVEKQHDGDLEEID 719

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   754 GLLDCPIFLTDLEPGEKLESMSAKERSFMCSLIFLTLNWFREIVNAFCQETSPEMKGKVLTRLKHIVELQIILEKYLAVT 833
Cdd:pfam14631  720 GLLGCPLILTDLEVGEKLESLSKKEREFLCSLLFHTINWFREVVNAFCQQKDPEMKGKVLTRLQNITELQSLLEKYLAVT 799

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   834 PDYVPPLGNFDvetlditphtvtaisakirkkgkierkqktdgsktssSDTLSEEKNSECDPTPSHRGQLNKEFTGKEEK 913
Cdd:pfam14631  800 PGYVPPLANFD-------------------------------------LDSSQKEEASEAEESQSEKSQLEKEFKGKEGK 842

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   914 TSLLLHNSHAFFRELDIEVFSILHCGLVTKFILDTEMHTEATEVVQLGPPELLFLLEDLSQKLESMLTPPIARRVPFLKN 993
Cdd:pfam14631  843 TGVSLQSYRAFFRELDIEVFSVLHCGLLTKSLLDTEMHTKAREEVQLGPAELLFLLEDLSRKLEFMLTPAPAKRAPFLKG 922

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   994 KGSRNIGFSHLQQRSAQEIVHCVFQLLTPMCNHLENIHNYFQCLAAENHGVVDGPGVKVQEYHIMSSCYQRLLQIFHGLF 1073
Cdd:pfam14631  923 KGDRNVGFSHLQQRSAQEIAHCVVQLLPPLCNHLENIHNYFQCLLAENHGVVDGPGVDVQEHQLMSSCYQLLLQVLHTLF 1002

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  1074 AWSGFSQPENQNLLYSALHVLSSRLKQGEHSQPLEELLSQSVHYLQNFHQSIPSFQCALYLIRLLMVILEKSTASAQNKE 1153
Cdd:pfam14631 1003 AWSGFSQPENRSLLKSALGVLAGRLKEGEAELTLEELVSHSFEYLQNFRSSVPSFQCALCLIQLLIVIAEKSGNPAAKRE 1082

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  1154 KIASLARQFLCRVW--PSGDKEKSNISNDQLHALLCIYLEHTESILKAIEEIAGVGVPELINSPKDASSSTFPTLTRHTF 1231
Cdd:pfam14631 1083 KIASLARQFLCQVWvtPSGEKEKGNKFNDALHTLLCIYLEHTDDVLKAIEEIAGEGVPELINSSKDASSSTFPTLTRQTF 1162

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  1232 VVFFRVMMAELEKTVKKIEPGTAADSQQIHEEKLLYWNMAVRDFSILINLIKVFDSHPVLHVCLKYGRLFVEAFLKQCMP 1311
Cdd:pfam14631 1163 LVFFRVMMAELEKSVRKIQPGTASDSQEVQEEKLLYWNMAVRDFHILVNLVKVFDSRPVLHVCLKYGRLFVEAFLKLGMP 1242

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  1312 LLDFSFRKHREDVLSLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPLLKKTLELLVCRVKAMLTLNNCREAFWLGNLKN 1391
Cdd:pfam14631 1243 LLDFSFKKHREDVQSLLKTFQLSTRQLHHMCGHSKIHQDTGLTNHVPLLKKSLELFVYRVKAMLVLNNCQEAFWLGNLKN 1322

                         1370      1380
                   ....*....|....*....|....
gi 987437912  1392 RDLQGEEIKSQNSQESTADESEDD 1415
Cdd:pfam14631 1323 RDLQGEEILSQRSQESDEEEEEDS 1346
 
Name Accession Description Interval E-value
FancD2 pfam14631
Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease ...
 35-1415 0e+00

Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.


Pssm-ID: 464225  Cd Length: 1346  Bit Score: 2493.08  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912    35 SHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHPSYPKIIEEFVSGLESYIEDEDSFRNCL 114
Cdd:pfam14631    1 SHAQNEVEENGSVFVKLLKTAGVILKTGENQNEIAVDQVIFQKKLQQALRKHPSYPKVIEEFITGLESYIEDRDTFRNCL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   115 LSCERLQDEEA-SMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIVSQLKWLDRVVDGKDLT 193
Cdd:pfam14631   81 LPCVPLQSEEAsSMVTSYQESLIKLLLGIEILQPAIIKTLFEKLPEFMFESVNSDGLNMPRLIINQLKWLDRIVDGKDLT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   194 TKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVMDKLSSI 273
Cdd:pfam14631  161 SKLMQLISVAPVELQHDIITSLPEILEDSQHNDVARELSSLLVENTQLTVPILDALSSLNLDPTLLSEVRQAVMGTLSAV 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   274 RLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSA 353
Cdd:pfam14631  241 QLEDLPVVVKFILHSVSATDAYEVISELRKKLDLEQCVLPPVLQASQSKLKSKGAASSSGNQASSSQDCISLVFDVIKSA 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   354 IRYEKTISEAWIKAIENTASVSEHKVFDLVMLFIIYSTNTQTKKYIDRVLRNKIRSGCIQEQLLQSTFSVHYLVLKDMCS 433
Cdd:pfam14631  321 VRFQKTISEAWLKAIENIDSVSDHKVLDLLMLFIIYSTNANQKKGIERVLRNKVRSGCIQEQLLQSTFRTHALVLRDYFP 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   434 SILSLAQSLLHSLDQSIISFGSLLYKYAFKFFDTYCQQEVVGALVTHICSGNEAEVDTALDVLLELVVLNPSAMMMNAVF 513
Cdd:pfam14631  401 SILALAQSLLHSPDQSIVSFGSHMYKYAFTAFDSYCQQEVVGALVTHVCSGNEAEVDVALELLLELVVLKPSAMRLYAVF 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   514 VKGILDYLDNISPQQIRKLFYVLSTLAFSKQNEASSHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAADRSESp 593
Cdd:pfam14631  481 VKGILDYMDNLTPQQIRKLFHILSTLAFSQQHEQSSHIQDDMHIVIRKQLSSTVPKYKRIGIIGAVTMVGSMAADRSKS- 559

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   594 SLTQERANLSDEQCTQVTSLLQLVHSCSEQSPQASALYYDEFANLIQHEKLDPKALEWVGHTICNDFQDAFVVDSCVVPE 673
Cdd:pfam14631  560 GSSSQSASLSKEQCRQVTSLLELVHSCSEQSPQAAALYYDELANLIQKGKLDPKVLEWIGQSVLNDFQDDFVVDLGPDIE 639

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   674 GDFPFPVKALYGLEEYDTQDGIAINLLPLLFSQDFAKDGGPVTSQESGQKLVSPLCLAPYFRLLRLCVERQHNGNLEEID 753
Cdd:pfam14631  640 GDFPFPVKALYGLEEEESQGGIAINLLPLLAKDEQAKDEGEVTAQEKGQKRVSPLCLSPFFRLLRLCVEKQHDGDLEEID 719

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   754 GLLDCPIFLTDLEPGEKLESMSAKERSFMCSLIFLTLNWFREIVNAFCQETSPEMKGKVLTRLKHIVELQIILEKYLAVT 833
Cdd:pfam14631  720 GLLGCPLILTDLEVGEKLESLSKKEREFLCSLLFHTINWFREVVNAFCQQKDPEMKGKVLTRLQNITELQSLLEKYLAVT 799

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   834 PDYVPPLGNFDvetlditphtvtaisakirkkgkierkqktdgsktssSDTLSEEKNSECDPTPSHRGQLNKEFTGKEEK 913
Cdd:pfam14631  800 PGYVPPLANFD-------------------------------------LDSSQKEEASEAEESQSEKSQLEKEFKGKEGK 842

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   914 TSLLLHNSHAFFRELDIEVFSILHCGLVTKFILDTEMHTEATEVVQLGPPELLFLLEDLSQKLESMLTPPIARRVPFLKN 993
Cdd:pfam14631  843 TGVSLQSYRAFFRELDIEVFSVLHCGLLTKSLLDTEMHTKAREEVQLGPAELLFLLEDLSRKLEFMLTPAPAKRAPFLKG 922

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   994 KGSRNIGFSHLQQRSAQEIVHCVFQLLTPMCNHLENIHNYFQCLAAENHGVVDGPGVKVQEYHIMSSCYQRLLQIFHGLF 1073
Cdd:pfam14631  923 KGDRNVGFSHLQQRSAQEIAHCVVQLLPPLCNHLENIHNYFQCLLAENHGVVDGPGVDVQEHQLMSSCYQLLLQVLHTLF 1002

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  1074 AWSGFSQPENQNLLYSALHVLSSRLKQGEHSQPLEELLSQSVHYLQNFHQSIPSFQCALYLIRLLMVILEKSTASAQNKE 1153
Cdd:pfam14631 1003 AWSGFSQPENRSLLKSALGVLAGRLKEGEAELTLEELVSHSFEYLQNFRSSVPSFQCALCLIQLLIVIAEKSGNPAAKRE 1082

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  1154 KIASLARQFLCRVW--PSGDKEKSNISNDQLHALLCIYLEHTESILKAIEEIAGVGVPELINSPKDASSSTFPTLTRHTF 1231
Cdd:pfam14631 1083 KIASLARQFLCQVWvtPSGEKEKGNKFNDALHTLLCIYLEHTDDVLKAIEEIAGEGVPELINSSKDASSSTFPTLTRQTF 1162

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  1232 VVFFRVMMAELEKTVKKIEPGTAADSQQIHEEKLLYWNMAVRDFSILINLIKVFDSHPVLHVCLKYGRLFVEAFLKQCMP 1311
Cdd:pfam14631 1163 LVFFRVMMAELEKSVRKIQPGTASDSQEVQEEKLLYWNMAVRDFHILVNLVKVFDSRPVLHVCLKYGRLFVEAFLKLGMP 1242

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  1312 LLDFSFRKHREDVLSLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPLLKKTLELLVCRVKAMLTLNNCREAFWLGNLKN 1391
Cdd:pfam14631 1243 LLDFSFKKHREDVQSLLKTFQLSTRQLHHMCGHSKIHQDTGLTNHVPLLKKSLELFVYRVKAMLVLNNCQEAFWLGNLKN 1322

                         1370      1380
                   ....*....|....*....|....
gi 987437912  1392 RDLQGEEIKSQNSQESTADESEDD 1415
Cdd:pfam14631 1323 RDLQGEEILSQRSQESDEEEEEDS 1346
FANCD2 cd11721
Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi ...
 90-1403 0e+00

Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome. The phosphorylation of FANCD2 is required for DNA damage-induced intra-S phase checkpoint and for cellular resistance to DNA crosslinking agents.


Pssm-ID: 212595  Cd Length: 1161  Bit Score: 1331.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   90 PKIIEEFVSGLESYIEDEDSFRNCLLSCERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFE-NKNSD 168
Cdd:cd11721     1 PENVDEFLSGLEDFLADRDRLRKALLPCNLLTTESSSASSVPQDSLIRLLLQVDPLQPKVIELLLEKLPEFLDEdASVPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  169 EINIPRLIVSQLKWLDRVVDGKDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDV 248
Cdd:cd11721    81 EDNLPRLILNQFKWLDHIVDSEDLTEKLLELLSVAPSELQKEIITSLPEIIGDSQHEDVAEELCKLLQENSELTVPILDA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  249 LSSLRLDPNFLLKVRQLVMDKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLqasqvklkskgr 328
Cdd:cd11721   161 LSNLNLSPELLSEIREKVLSCLKTVPLEDLPVLVKFLLQSITATEALEIISKLRKNLDFSPLSDPSSS------------ 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  329 aSSSGNQESSGQSCIILLFDVIKSAIRYEKTISEAWIKAIENTASVSEHKVFDLVMLFIIYSTNTQTKKYIDRVLRNKIR 408
Cdd:cd11721   229 -GSSDKSKASANSCQSLILEAIKSALRFSKLLAEAWIKVISSIDAPQDHKVIDLILLLILYSTNEDKRKSIESLLKKKIK 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  409 SGCIQEQLLQSTFSVHYLVLKDMCSSILSLAQSLLHSLDQSIISFGSLLYKYAFKFFDTYCQQEVVGALVTHICSGNEAE 488
Cdd:cd11721   308 SGFIRTSLLDLAFTGHSQVLKDYFKSLLSLADNLLRSAEPVVREFGSHLYKLLFKHFDRYYQQEVVGALITHIGSGNSSE 387

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  489 VDTALDVLLELVVLNPSAMMMNAVFVKGILDYLDNISPQQIRKLFYVLSTLAFS-KQNEASSHIQDDMHLVIRKQLSSTV 567
Cdd:cd11721   388 VDAALDVLRELAEKNPDELLPYATFIKGILDYLDSLNLKQIRQLFDILCHLAFSeRPLSEGSSIQDDLHIIVRKQLSNSS 467

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  568 FKYKLIGIIGAVTMAGIMAADRSESPSLTQERAN---LSDEQCTQVTSLLQLVHSCSEQSPQASALYYDEFANLIQHE-K 643
Cdd:cd11721   468 PKYKRMGIIGAVTLVKHLASANSSDDAVERSSSNgssLPDERLKQAANLLELVLSSCKNSPEALALFYDELANIISQAsN 547

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  644 LDPKALEWVGHTICNDFQDAFVVDscvvpegdfpfpvkalygLEEYdtqdgiainllpllfsqdfakdggpvtsqesgqk 723
Cdd:cd11721   548 LDPKFLEWLGETITEDFQESFVVD------------------LDET---------------------------------- 575

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  724 lvSPLCLAPYFRLLRLCVERQHNGNLEEIDGLLDCPIFLTDLEPGEKLESMSAKERSFMCSLIFLTLNWFREIVNAFCQE 803
Cdd:cd11721   576 --SSAILASLFRLLRLLERSQQGGSLDEIDALLGCPLVLPDFEVDEKFDSLSTEQRSVVLDCLFYAINWFREVINAFATQ 653

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  804 TSPEMKGKVLTRLKHIVELQIILEKYLavtpdyvpplgnfdvetlditphtvtaisakirkkgkierkqktdgsktsssd 883
Cdd:cd11721   654 KDASTKKKVLKRLRNLIELEGRLSKLL----------------------------------------------------- 680

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  884 tlseeknsecdptpshrgqlnkeftgkeektslllhnSHAFFRELDIEVFSILHCGLVTKFILdtemHTEATEVVQLGPP 963
Cdd:cd11721   681 -------------------------------------AHCYFRELDLEVFSLLKSGLVTDTSL----ELSEEEGVHLGPK 719

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  964 ELLFLLEDLSQKLESMLTPPIARRVPFLKnKGSRNIGFSHLQQRSAQEIVHCVFQLLTPMCNHLENIHNYFQCLAAENHG 1043
Cdd:cd11721   720 ELRFLLEDLNRKLEHVLTSPKKKRMPLLK-PLKKGQGFSSLSQKSPKEVLKALVPLLPHLCKHLEKIHNYLQNLLLSNAG 798

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912 1044 VVDGPGVKVQEYHIMSSCYQRLLQIFHGLFAWSGFSQPENQNLLYSALHVLSSRLKQGEHS-QPLEELLSQSVHYLQNFH 1122
Cdd:cd11721   799 QLDAPGPFVQENQYAKSCYGLLLQCLRLLFAWPGFSSQSNRVLLKSALRAIASRLKESTGKdLPLKELVSSLFKYLKSFE 878

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912 1123 QSIPSFQCALYLIRLLMVILEKSTASAQNKEKIASLARQFLCRVWP--SGDKEKSNISNDQLHALLCIYLEHTESILKAI 1200
Cdd:cd11721   879 PSVPSLSTAVSLVQLLQALMEKSPDRPQLREKLADLARNFLCRQWPdlSGESEKGQKYNDLIDTLLRIYLEHSDDPLKKL 958

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912 1201 EEIAGVGVPELINSPKD-ASSSTFPTLTRHTFVVFFRVMMAELEKTVKKIEPGtAADSQQIHEEKLLYWNMAVRDFSILI 1279
Cdd:cd11721   959 EEIAGEALPELLEKKKDkDALETFPTLSKSTFPIFFRVLMEALIESVKKILSS-AADTGGGEMERLLLWQSAVRVFKALV 1037

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912 1280 NLIKVFDSHPVLHVCLKYGRLFVEAFLKQCMPLLDFSFRKHREDVLSLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPL 1359
Cdd:cd11721  1038 NLVKTFDKRPVLAICLKYGRLFLKLFLKLGMPLLEKLFKNHKEEVQELLKTLQQSTRYLHHICCHSKIHKDTALTNHVPA 1117

                        1290      1300      1310      1320
                  ....*....|....*....|....*....|....*....|....
gi 987437912 1360 LKKTLELLVCRVKAMLTLNNCREAFWLGNLKNRDLQGEEIKSQN 1403
Cdd:cd11721  1118 LKKSLETLVYRVKAMLVANNCSEAFWMGNLKNKDLQGEEILSQR 1161
 
Name Accession Description Interval E-value
FancD2 pfam14631
Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease ...
 35-1415 0e+00

Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.


Pssm-ID: 464225  Cd Length: 1346  Bit Score: 2493.08  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912    35 SHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHPSYPKIIEEFVSGLESYIEDEDSFRNCL 114
Cdd:pfam14631    1 SHAQNEVEENGSVFVKLLKTAGVILKTGENQNEIAVDQVIFQKKLQQALRKHPSYPKVIEEFITGLESYIEDRDTFRNCL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   115 LSCERLQDEEA-SMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIVSQLKWLDRVVDGKDLT 193
Cdd:pfam14631   81 LPCVPLQSEEAsSMVTSYQESLIKLLLGIEILQPAIIKTLFEKLPEFMFESVNSDGLNMPRLIINQLKWLDRIVDGKDLT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   194 TKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVMDKLSSI 273
Cdd:pfam14631  161 SKLMQLISVAPVELQHDIITSLPEILEDSQHNDVARELSSLLVENTQLTVPILDALSSLNLDPTLLSEVRQAVMGTLSAV 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   274 RLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSA 353
Cdd:pfam14631  241 QLEDLPVVVKFILHSVSATDAYEVISELRKKLDLEQCVLPPVLQASQSKLKSKGAASSSGNQASSSQDCISLVFDVIKSA 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   354 IRYEKTISEAWIKAIENTASVSEHKVFDLVMLFIIYSTNTQTKKYIDRVLRNKIRSGCIQEQLLQSTFSVHYLVLKDMCS 433
Cdd:pfam14631  321 VRFQKTISEAWLKAIENIDSVSDHKVLDLLMLFIIYSTNANQKKGIERVLRNKVRSGCIQEQLLQSTFRTHALVLRDYFP 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   434 SILSLAQSLLHSLDQSIISFGSLLYKYAFKFFDTYCQQEVVGALVTHICSGNEAEVDTALDVLLELVVLNPSAMMMNAVF 513
Cdd:pfam14631  401 SILALAQSLLHSPDQSIVSFGSHMYKYAFTAFDSYCQQEVVGALVTHVCSGNEAEVDVALELLLELVVLKPSAMRLYAVF 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   514 VKGILDYLDNISPQQIRKLFYVLSTLAFSKQNEASSHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAADRSESp 593
Cdd:pfam14631  481 VKGILDYMDNLTPQQIRKLFHILSTLAFSQQHEQSSHIQDDMHIVIRKQLSSTVPKYKRIGIIGAVTMVGSMAADRSKS- 559

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   594 SLTQERANLSDEQCTQVTSLLQLVHSCSEQSPQASALYYDEFANLIQHEKLDPKALEWVGHTICNDFQDAFVVDSCVVPE 673
Cdd:pfam14631  560 GSSSQSASLSKEQCRQVTSLLELVHSCSEQSPQAAALYYDELANLIQKGKLDPKVLEWIGQSVLNDFQDDFVVDLGPDIE 639

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   674 GDFPFPVKALYGLEEYDTQDGIAINLLPLLFSQDFAKDGGPVTSQESGQKLVSPLCLAPYFRLLRLCVERQHNGNLEEID 753
Cdd:pfam14631  640 GDFPFPVKALYGLEEEESQGGIAINLLPLLAKDEQAKDEGEVTAQEKGQKRVSPLCLSPFFRLLRLCVEKQHDGDLEEID 719

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   754 GLLDCPIFLTDLEPGEKLESMSAKERSFMCSLIFLTLNWFREIVNAFCQETSPEMKGKVLTRLKHIVELQIILEKYLAVT 833
Cdd:pfam14631  720 GLLGCPLILTDLEVGEKLESLSKKEREFLCSLLFHTINWFREVVNAFCQQKDPEMKGKVLTRLQNITELQSLLEKYLAVT 799

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   834 PDYVPPLGNFDvetlditphtvtaisakirkkgkierkqktdgsktssSDTLSEEKNSECDPTPSHRGQLNKEFTGKEEK 913
Cdd:pfam14631  800 PGYVPPLANFD-------------------------------------LDSSQKEEASEAEESQSEKSQLEKEFKGKEGK 842

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   914 TSLLLHNSHAFFRELDIEVFSILHCGLVTKFILDTEMHTEATEVVQLGPPELLFLLEDLSQKLESMLTPPIARRVPFLKN 993
Cdd:pfam14631  843 TGVSLQSYRAFFRELDIEVFSVLHCGLLTKSLLDTEMHTKAREEVQLGPAELLFLLEDLSRKLEFMLTPAPAKRAPFLKG 922

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   994 KGSRNIGFSHLQQRSAQEIVHCVFQLLTPMCNHLENIHNYFQCLAAENHGVVDGPGVKVQEYHIMSSCYQRLLQIFHGLF 1073
Cdd:pfam14631  923 KGDRNVGFSHLQQRSAQEIAHCVVQLLPPLCNHLENIHNYFQCLLAENHGVVDGPGVDVQEHQLMSSCYQLLLQVLHTLF 1002

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  1074 AWSGFSQPENQNLLYSALHVLSSRLKQGEHSQPLEELLSQSVHYLQNFHQSIPSFQCALYLIRLLMVILEKSTASAQNKE 1153
Cdd:pfam14631 1003 AWSGFSQPENRSLLKSALGVLAGRLKEGEAELTLEELVSHSFEYLQNFRSSVPSFQCALCLIQLLIVIAEKSGNPAAKRE 1082

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  1154 KIASLARQFLCRVW--PSGDKEKSNISNDQLHALLCIYLEHTESILKAIEEIAGVGVPELINSPKDASSSTFPTLTRHTF 1231
Cdd:pfam14631 1083 KIASLARQFLCQVWvtPSGEKEKGNKFNDALHTLLCIYLEHTDDVLKAIEEIAGEGVPELINSSKDASSSTFPTLTRQTF 1162

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  1232 VVFFRVMMAELEKTVKKIEPGTAADSQQIHEEKLLYWNMAVRDFSILINLIKVFDSHPVLHVCLKYGRLFVEAFLKQCMP 1311
Cdd:pfam14631 1163 LVFFRVMMAELEKSVRKIQPGTASDSQEVQEEKLLYWNMAVRDFHILVNLVKVFDSRPVLHVCLKYGRLFVEAFLKLGMP 1242

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  1312 LLDFSFRKHREDVLSLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPLLKKTLELLVCRVKAMLTLNNCREAFWLGNLKN 1391
Cdd:pfam14631 1243 LLDFSFKKHREDVQSLLKTFQLSTRQLHHMCGHSKIHQDTGLTNHVPLLKKSLELFVYRVKAMLVLNNCQEAFWLGNLKN 1322

                         1370      1380
                   ....*....|....*....|....
gi 987437912  1392 RDLQGEEIKSQNSQESTADESEDD 1415
Cdd:pfam14631 1323 RDLQGEEILSQRSQESDEEEEEDS 1346
FANCD2 cd11721
Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi ...
 90-1403 0e+00

Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome. The phosphorylation of FANCD2 is required for DNA damage-induced intra-S phase checkpoint and for cellular resistance to DNA crosslinking agents.


Pssm-ID: 212595  Cd Length: 1161  Bit Score: 1331.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912   90 PKIIEEFVSGLESYIEDEDSFRNCLLSCERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFE-NKNSD 168
Cdd:cd11721     1 PENVDEFLSGLEDFLADRDRLRKALLPCNLLTTESSSASSVPQDSLIRLLLQVDPLQPKVIELLLEKLPEFLDEdASVPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  169 EINIPRLIVSQLKWLDRVVDGKDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDV 248
Cdd:cd11721    81 EDNLPRLILNQFKWLDHIVDSEDLTEKLLELLSVAPSELQKEIITSLPEIIGDSQHEDVAEELCKLLQENSELTVPILDA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  249 LSSLRLDPNFLLKVRQLVMDKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLqasqvklkskgr 328
Cdd:cd11721   161 LSNLNLSPELLSEIREKVLSCLKTVPLEDLPVLVKFLLQSITATEALEIISKLRKNLDFSPLSDPSSS------------ 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  329 aSSSGNQESSGQSCIILLFDVIKSAIRYEKTISEAWIKAIENTASVSEHKVFDLVMLFIIYSTNTQTKKYIDRVLRNKIR 408
Cdd:cd11721   229 -GSSDKSKASANSCQSLILEAIKSALRFSKLLAEAWIKVISSIDAPQDHKVIDLILLLILYSTNEDKRKSIESLLKKKIK 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  409 SGCIQEQLLQSTFSVHYLVLKDMCSSILSLAQSLLHSLDQSIISFGSLLYKYAFKFFDTYCQQEVVGALVTHICSGNEAE 488
Cdd:cd11721   308 SGFIRTSLLDLAFTGHSQVLKDYFKSLLSLADNLLRSAEPVVREFGSHLYKLLFKHFDRYYQQEVVGALITHIGSGNSSE 387

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  489 VDTALDVLLELVVLNPSAMMMNAVFVKGILDYLDNISPQQIRKLFYVLSTLAFS-KQNEASSHIQDDMHLVIRKQLSSTV 567
Cdd:cd11721   388 VDAALDVLRELAEKNPDELLPYATFIKGILDYLDSLNLKQIRQLFDILCHLAFSeRPLSEGSSIQDDLHIIVRKQLSNSS 467

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  568 FKYKLIGIIGAVTMAGIMAADRSESPSLTQERAN---LSDEQCTQVTSLLQLVHSCSEQSPQASALYYDEFANLIQHE-K 643
Cdd:cd11721   468 PKYKRMGIIGAVTLVKHLASANSSDDAVERSSSNgssLPDERLKQAANLLELVLSSCKNSPEALALFYDELANIISQAsN 547

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  644 LDPKALEWVGHTICNDFQDAFVVDscvvpegdfpfpvkalygLEEYdtqdgiainllpllfsqdfakdggpvtsqesgqk 723
Cdd:cd11721   548 LDPKFLEWLGETITEDFQESFVVD------------------LDET---------------------------------- 575

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  724 lvSPLCLAPYFRLLRLCVERQHNGNLEEIDGLLDCPIFLTDLEPGEKLESMSAKERSFMCSLIFLTLNWFREIVNAFCQE 803
Cdd:cd11721   576 --SSAILASLFRLLRLLERSQQGGSLDEIDALLGCPLVLPDFEVDEKFDSLSTEQRSVVLDCLFYAINWFREVINAFATQ 653

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  804 TSPEMKGKVLTRLKHIVELQIILEKYLavtpdyvpplgnfdvetlditphtvtaisakirkkgkierkqktdgsktsssd 883
Cdd:cd11721   654 KDASTKKKVLKRLRNLIELEGRLSKLL----------------------------------------------------- 680

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  884 tlseeknsecdptpshrgqlnkeftgkeektslllhnSHAFFRELDIEVFSILHCGLVTKFILdtemHTEATEVVQLGPP 963
Cdd:cd11721   681 -------------------------------------AHCYFRELDLEVFSLLKSGLVTDTSL----ELSEEEGVHLGPK 719

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  964 ELLFLLEDLSQKLESMLTPPIARRVPFLKnKGSRNIGFSHLQQRSAQEIVHCVFQLLTPMCNHLENIHNYFQCLAAENHG 1043
Cdd:cd11721   720 ELRFLLEDLNRKLEHVLTSPKKKRMPLLK-PLKKGQGFSSLSQKSPKEVLKALVPLLPHLCKHLEKIHNYLQNLLLSNAG 798

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912 1044 VVDGPGVKVQEYHIMSSCYQRLLQIFHGLFAWSGFSQPENQNLLYSALHVLSSRLKQGEHS-QPLEELLSQSVHYLQNFH 1122
Cdd:cd11721   799 QLDAPGPFVQENQYAKSCYGLLLQCLRLLFAWPGFSSQSNRVLLKSALRAIASRLKESTGKdLPLKELVSSLFKYLKSFE 878

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912 1123 QSIPSFQCALYLIRLLMVILEKSTASAQNKEKIASLARQFLCRVWP--SGDKEKSNISNDQLHALLCIYLEHTESILKAI 1200
Cdd:cd11721   879 PSVPSLSTAVSLVQLLQALMEKSPDRPQLREKLADLARNFLCRQWPdlSGESEKGQKYNDLIDTLLRIYLEHSDDPLKKL 958

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912 1201 EEIAGVGVPELINSPKD-ASSSTFPTLTRHTFVVFFRVMMAELEKTVKKIEPGtAADSQQIHEEKLLYWNMAVRDFSILI 1279
Cdd:cd11721   959 EEIAGEALPELLEKKKDkDALETFPTLSKSTFPIFFRVLMEALIESVKKILSS-AADTGGGEMERLLLWQSAVRVFKALV 1037

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912 1280 NLIKVFDSHPVLHVCLKYGRLFVEAFLKQCMPLLDFSFRKHREDVLSLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPL 1359
Cdd:cd11721  1038 NLVKTFDKRPVLAICLKYGRLFLKLFLKLGMPLLEKLFKNHKEEVQELLKTLQQSTRYLHHICCHSKIHKDTALTNHVPA 1117

                        1290      1300      1310      1320
                  ....*....|....*....|....*....|....*....|....
gi 987437912 1360 LKKTLELLVCRVKAMLTLNNCREAFWLGNLKNRDLQGEEIKSQN 1403
Cdd:cd11721  1118 LKKSLETLVYRVKAMLVANNCSEAFWMGNLKNKDLQGEEILSQR 1161
FANC cd11719
Fanconi anemia ID complex proteins FANCI and FANCD2; The Fanconi anemia ID complex consists of ...
 131-1280 0e+00

Fanconi anemia ID complex proteins FANCI and FANCD2; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome.


Pssm-ID: 212593  Cd Length: 977  Bit Score: 1012.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  131 YSKSLIKLLLGID----ILQPAIIKTLFEKLPEYFFENKN-SDEINIPRLIVSQLKWLDRVVDGKDLTTKIMQLISIAPE 205
Cdd:cd11719     2 AVGTLLRAVLKGSpcseEDGALRRYKIYSCCIQLVESGDLqQDVASEIIGLLMLEVHHFPGPLLVDLASDFVGAVREDRL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  206 NLQHDIITSLPEILG-----------------DSQHADVGKELSDLLiENTSLTVPILDVLSSLRLDPNFLLKVRQLVMD 268
Cdd:cd11719    82 VNGKSLELLPIILTAlatkkevlacgkgdlngEEYKRQLIDTLCSVR-WPQRYMIQLTSVFKDVCLTPEEMNLVVAKVLT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  269 KLSSIRLEDLPVIIKFILHS---VTAMDTLEVISELREKLDLQHCVLPSRLQAsqvklkskgrASSSGNQESSGQSCIIL 345
Cdd:cd11719   161 MFSKLNLQEIPPLVYQLLVLsskGSRRSVLDGIIAFFRELDKQHREEQSSDEL----------SELITAPADELYHVEGT 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  346 LFDVIKSAIRYE-KTISEAWIKAIE--NTASVSEHKVFDLVMLFIIYSTNTQTKKYIDRVLRNKIRSGC----------- 411
Cdd:cd11719   231 VILHIVFAIKLDcELGRELLKHLKAgqQGDPSKCLCPFSIALLLSLTRIQRFEEQVFDLLKTSVVKSFKdlqllqgskfl 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  412 --------IQEQLLQSTFSVHYLVLKDMCSSILSLAQSLLHSL---------------------DQSIISFGSLLYKYAF 462
Cdd:cd11719   311 qtlvpqrtCVSTMILEVVRNSVHSWDHVTQGLIEFGFILMDSYgpkkildgkaveigtslskmtNQHACKLGANILLETF 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  463 KfFDTYCQQEVVGALVTHICSGNEAEVDTALDVLLELVVLNPSAmMMNAVFVKGILDYLDNISPQQIRKLFYVLSTLAFS 542
Cdd:cd11719   391 K-IHEMIRQEILEQVLNRVVTRTSSPINHFLDLFSDIIMYAPLI-LQNCSKVTETFDYLTFLPLQTVQGLLKAVQPLLKI 468

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  543 KqneasSHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAADRS------------ESPSLTQERANLSDEQCTQV 610
Cdd:cd11719   469 S-----MSMRDSLILVLRKAMFASQLDARKSAVAGFLLLLKNFKVLGSlpssqctqsigvTQVRVDVHSRYSAVANETFC 543

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  611 TSLLQLVHSCSEQSPQASALYYDEfanliqhEKLDPKALEWVGHTICNDFQDAFVVDSCVVPEGDFPFPVKAlygleeyd 690
Cdd:cd11719   544 LEIIDSLKRSLGQQADIRLMLYDG-------FYDVLRRNSQLASSIMQTLFSQLKQFYEPEPDLLPPLKLGA-------- 608

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  691 tqdgiainllpllfsqdfakdggpvTSQESGQKLVSPLCLAPYFRLLRLCVERQhngnleeidglldcpifltdlepgek 770
Cdd:cd11719   609 -------------------------CVLTQGSQIFLQEPLDHLLSCIQHCLAWY-------------------------- 637

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  771 lesmsakersfmcsliflTLNWFREIVNAFCQETSPE-----MKGKVLTRLKHIVELQIIlekylavtpdyvpplgnfdv 845
Cdd:cd11719   638 ------------------ACLIMGVCEVLMEYNFSISnfsksKFEEILSLFTCYKKFSDI-------------------- 679

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  846 etlditphtvtaisakirkkgkierkqktdgsktsssdtlseeknsecdptpshrgqlnkeftgkeektslllhnshaff 925
Cdd:cd11719       --------------------------------------------------------------------------------

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912  926 relDIEVFSILHCGLVTKFILDT---EMHTEATEVVQLGPPELLFLLEDLSQKLESmltppiarrvpflknkgsrnigfs 1002
Cdd:cd11719   680 ---IFQNLCDITRVLLWRYTSIPtsvEESGKKEKGKSISLLCLEGLQKTFSVVLQF------------------------ 732

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912 1003 hlqqrsaqeIVHCVFQLL-----------------TPMCNHLENIHNYFQCLAAENHGVvdgpgvkVQEYHIMSSCYQRL 1065
Cdd:cd11719   733 ---------YQPKVQQFLqaldvmgteeeeagvtvTQRASFQIRQFQRSLLNLLSSEED-------DFNSKEALLLIAVL 796

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912 1066 LQIFHGLFAwsgfsqpenqnllysalhvlssrlkqgehsqpleelLSQSVHYLQNFHQ----------SIPSFQCALYLI 1135
Cdd:cd11719   797 STLSRLLEP------------------------------------TSPQFVQMLSWTSkickeysqedASFCKSLMNLFF 840

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912 1136 RLLMVILEkstasaqnkekiASLARQFLCRVWPSGDK-----------------EKSNISNDQLHALLCIYLEhtESILK 1198
Cdd:cd11719   841 SLHVLYKS------------PVTLLRDLSQDIHGQLGdidqdveiektdhfavvNLRTAAPTVCLLVLSQAEK--VMQLG 906

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987437912 1199 AIEEIAGVGVPElinspkdassSTFPTLTRHTFVVFFRVMMAELEKTVKKIEPGTaADSQQIHEEKLLYWNMAVRDFSIL 1278
Cdd:cd11719   907 TLVTFFHELVQT----------ALPSGSCVDTLLKGLSKIYSTLTAFVKYYLQVC-QSSRGIPNTVEKLVKLSGSHLTPV 975


                  ..
gi 987437912 1279 IN 1280
Cdd:cd11719   976 CY 977
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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