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Conserved domains on  [gi|999808071|ref|NP_001307326|]
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PEST proteolytic signal-containing nuclear protein isoform c [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PCNP super family cl21289
PEST, proteolytic signal-containing nuclear protein family; PCNP is a PEST-containing nuclear ...
 22-138 1.26e-46

PEST, proteolytic signal-containing nuclear protein family; PCNP is a PEST-containing nuclear protein that is ubiquitinated by NIRF, a Np95/ICBP90-like RING finger protein. PEST sequences, which are rich in proline (P), glutamic acid (E), serine (S) and threonine (T), are found in a number of short-lived proteins, such as transcription factors and cell cycle-associated proteins. Their function is generally controlled by proteolysis, mostly via ubiquitin-mediated degradation. Thus, NIRF and PCNP are a ubiquitin ligase and its substrate, respectively, that may constitute a novel signalling pathway with some relation to cell proliferation.


The actual alignment was detected with superfamily member pfam15473:

Pssm-ID: 464736  Cd Length: 155  Bit Score: 148.46  E-value: 1.26e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999808071   22 GPEEEAEKPVKTKTVSSSNGGESSSRS----AEKRSAEEEAAD--LPTKPTKISKFGFAI-------------------- 75
Cdd:pfam15473   1 GPEERRRKEVKTKTVSSRPRVGGRGRSssrsDDKRSAEEEDESdeAPPAPPKISKIGFSFskqaakkpkpisiklgatsk 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 999808071   76 ------------VAAAFNEDEDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDNQKLWERNIKSHLG 138
Cdd:pfam15473  81 pkepvpklkkptVASVFNEDDDSEPEEMPAEARMRMRNIGRETPTSAGPNSFGKTKHGFCDSKKLWEKKLKSHTD 155
 
Name Accession Description Interval E-value
PCNP pfam15473
PEST, proteolytic signal-containing nuclear protein family; PCNP is a PEST-containing nuclear ...
 22-138 1.26e-46

PEST, proteolytic signal-containing nuclear protein family; PCNP is a PEST-containing nuclear protein that is ubiquitinated by NIRF, a Np95/ICBP90-like RING finger protein. PEST sequences, which are rich in proline (P), glutamic acid (E), serine (S) and threonine (T), are found in a number of short-lived proteins, such as transcription factors and cell cycle-associated proteins. Their function is generally controlled by proteolysis, mostly via ubiquitin-mediated degradation. Thus, NIRF and PCNP are a ubiquitin ligase and its substrate, respectively, that may constitute a novel signalling pathway with some relation to cell proliferation.


Pssm-ID: 464736  Cd Length: 155  Bit Score: 148.46  E-value: 1.26e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999808071   22 GPEEEAEKPVKTKTVSSSNGGESSSRS----AEKRSAEEEAAD--LPTKPTKISKFGFAI-------------------- 75
Cdd:pfam15473   1 GPEERRRKEVKTKTVSSRPRVGGRGRSssrsDDKRSAEEEDESdeAPPAPPKISKIGFSFskqaakkpkpisiklgatsk 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 999808071   76 ------------VAAAFNEDEDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDNQKLWERNIKSHLG 138
Cdd:pfam15473  81 pkepvpklkkptVASVFNEDDDSEPEEMPAEARMRMRNIGRETPTSAGPNSFGKTKHGFCDSKKLWEKKLKSHTD 155
 
Name Accession Description Interval E-value
PCNP pfam15473
PEST, proteolytic signal-containing nuclear protein family; PCNP is a PEST-containing nuclear ...
 22-138 1.26e-46

PEST, proteolytic signal-containing nuclear protein family; PCNP is a PEST-containing nuclear protein that is ubiquitinated by NIRF, a Np95/ICBP90-like RING finger protein. PEST sequences, which are rich in proline (P), glutamic acid (E), serine (S) and threonine (T), are found in a number of short-lived proteins, such as transcription factors and cell cycle-associated proteins. Their function is generally controlled by proteolysis, mostly via ubiquitin-mediated degradation. Thus, NIRF and PCNP are a ubiquitin ligase and its substrate, respectively, that may constitute a novel signalling pathway with some relation to cell proliferation.


Pssm-ID: 464736  Cd Length: 155  Bit Score: 148.46  E-value: 1.26e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999808071   22 GPEEEAEKPVKTKTVSSSNGGESSSRS----AEKRSAEEEAAD--LPTKPTKISKFGFAI-------------------- 75
Cdd:pfam15473   1 GPEERRRKEVKTKTVSSRPRVGGRGRSssrsDDKRSAEEEDESdeAPPAPPKISKIGFSFskqaakkpkpisiklgatsk 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 999808071   76 ------------VAAAFNEDEDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDNQKLWERNIKSHLG 138
Cdd:pfam15473  81 pkepvpklkkptVASVFNEDDDSEPEEMPAEARMRMRNIGRETPTSAGPNSFGKTKHGFCDSKKLWEKKLKSHTD 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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