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Conserved domains on  [gi|1003701506|ref|NP_001307763|]
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sphingosine-1-phosphate phosphatase 2 isoform b [Homo sapiens]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 10130232)

type 2 phosphatidic acid phosphatase (PAP2) family protein is a type 2 lipid phosphate phosphatase, such as mammalian sphingosine-1-phosphate phosphatases and fungal dihydrosphingosine 1-phosphate phosphatase

CATH:  1.20.144.10
EC:  3.1.3.-
Gene Ontology:  GO:0042577|GO:0046839|GO:0008610
PubMed:  9122162|12447906|9260289
SCOP:  3001110|4001226

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_SPPase1 cd03388
PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an ...
 1-105 3.36e-46

PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second messenger in the cell, and extracellularly by binding to G-protein coupled receptors of the endothelial differentiation gene family.


:

Pssm-ID: 239482  Cd Length: 151  Bit Score: 152.00  E-value: 3.36e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003701506   1 MYIGQVAKDVLKWPRPSSPPVVKLEKRLIA-EYGMPSTHAMAATAIAFTLLISTMDRYQYPFVLGLVMAVVFSTLVCLSR 79
Cdd:cd03388    46 MYIGQFIKDLFCLPRPSSPPVVRLTMSSAAlEYGFPSTHAMNATAISFYLLIYLYDRYQYPFVLGLILALFYSTLVCLSR 125

                          90       100
                  ....*....|....*....|....*.
gi 1003701506  80 LYTGMHTVLDVLGGVLITALLIVLTY 105
Cdd:cd03388   126 IYMGMHSVLDVIAGSLIGVLILLFRF 151
 
Name Accession Description Interval E-value
PAP2_SPPase1 cd03388
PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an ...
 1-105 3.36e-46

PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second messenger in the cell, and extracellularly by binding to G-protein coupled receptors of the endothelial differentiation gene family.


Pssm-ID: 239482  Cd Length: 151  Bit Score: 152.00  E-value: 3.36e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003701506   1 MYIGQVAKDVLKWPRPSSPPVVKLEKRLIA-EYGMPSTHAMAATAIAFTLLISTMDRYQYPFVLGLVMAVVFSTLVCLSR 79
Cdd:cd03388    46 MYIGQFIKDLFCLPRPSSPPVVRLTMSSAAlEYGFPSTHAMNATAISFYLLIYLYDRYQYPFVLGLILALFYSTLVCLSR 125

                          90       100
                  ....*....|....*....|....*.
gi 1003701506  80 LYTGMHTVLDVLGGVLITALLIVLTY 105
Cdd:cd03388   126 IYMGMHSVLDVIAGSLIGVLILLFRF 151
PLN02525 PLN02525
phosphatidic acid phosphatase family protein
 2-222 1.37e-18

phosphatidic acid phosphatase family protein


Pssm-ID: 215288  Cd Length: 352  Bit Score: 84.02  E-value: 1.37e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003701506   2 YIGQVAKDVLKWPRPSSPPV-----VKLEKRLIAEYGMPSTHAMAATAIAFTLLISTMDRYQYP----FVLGLVMAVVFS 72
Cdd:PLN02525   49 YVGNCIKDVVSAPRPSCPPVrrvtaTKDEEENAMEYGLPSSHTLNTVCLSGYLLHYVLSYLQNVdasvIFAGLALFCLLV 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003701506  73 TLVCLSRLYTGMHTVLDVLGGVLITALLIVLtypaWTFIDC-LDS-------ASPLFpvcvIVVPFFLCYNYPVSDYYSP 144
Cdd:PLN02525  129 ALVGFGRLYLGMHSPIDIIAGLAIGLVILAF----WLTVDEyVDAfitsgqnVTPFW----AALSFLLLFAYPTPEFPTP 200

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1003701506 145 TRADTTTILAAGAGVTIGfwINHFFQlvSKPAESLPVIQNiPPLTTYMLvlgLTKFAVGIVLILLVRQLVQNLSLQVL 222
Cdd:PLN02525  201 SFEYHTAFNGVAFGIVAG--VQQTYS--QFHHEAAPRIFS-PQLPIAAF---LGRVAVGIPTILAVKFCSKALAKWLL 270
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 1-105 6.07e-13

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 63.98  E-value: 6.07e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003701506   1 MYIGQVAKDVLKWPRPS-----SPPVVKLEKRLIAEYGMPSTHAMAATAIAFTLLISTMDRYQYPFVLGLVMAVVFSTLV 75
Cdd:pfam01569  10 GLLSSVLKDYFGRPRPFfllleGGLVPAPSTLPGLGYSFPSGHSATAFALALLLALLLRRLRKIVRVLLALLLLVLALLV 89

                          90       100       110
                  ....*....|....*....|....*....|
gi 1003701506  76 CLSRLYTGMHTVLDVLGGVLITALLIVLTY 105
Cdd:pfam01569  90 GLSRLYLGVHFPSDVLAGALIGILLALLVY 119
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 6-108 5.71e-10

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 57.36  E-value: 5.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003701506   6 VAKDVLKWPRPSSPPVVKLEKRLIAEYGMPSTHAMAATAIAFTLListmdrYQYPFVLGLVMAVVFSTLVCLSRLYTGMH 85
Cdd:COG0671    91 LLKYLFGRPRPFVVPDLELLLGTAGGYSFPSGHAAAAFALALVLA------LLLPRRWLAALLLALALLVGLSRVYLGVH 164

                          90       100
                  ....*....|....*....|...
gi 1003701506  86 TVLDVLGGVLITALLIVLTYPAW 108
Cdd:COG0671   165 YPSDVLAGALLGLAIALLLLALL 187
acidPPc smart00014
Acid phosphatase homologues;
1-105 2.01e-08

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 51.19  E-value: 2.01e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003701506    1 MYIGQVAKDVLKW----PRP------SSPPVVKLEKRLIAEYGMPSTHAMAATAIAFTLLISTMDRYQYPFVLGLVMAVV 70
Cdd:smart00014   4 AVVSQLFNGVIKNyfgrPRPfflsigDACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYLPARAGRKLLIFLLLLLA 83

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1003701506   71 FstLVCLSRLYTGMHTVLDVLGGVLITALLIVLTY 105
Cdd:smart00014  84 L--VVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
 
Name Accession Description Interval E-value
PAP2_SPPase1 cd03388
PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an ...
 1-105 3.36e-46

PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second messenger in the cell, and extracellularly by binding to G-protein coupled receptors of the endothelial differentiation gene family.


Pssm-ID: 239482  Cd Length: 151  Bit Score: 152.00  E-value: 3.36e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003701506   1 MYIGQVAKDVLKWPRPSSPPVVKLEKRLIA-EYGMPSTHAMAATAIAFTLLISTMDRYQYPFVLGLVMAVVFSTLVCLSR 79
Cdd:cd03388    46 MYIGQFIKDLFCLPRPSSPPVVRLTMSSAAlEYGFPSTHAMNATAISFYLLIYLYDRYQYPFVLGLILALFYSTLVCLSR 125

                          90       100
                  ....*....|....*....|....*.
gi 1003701506  80 LYTGMHTVLDVLGGVLITALLIVLTY 105
Cdd:cd03388   126 IYMGMHSVLDVIAGSLIGVLILLFRF 151
PLN02525 PLN02525
phosphatidic acid phosphatase family protein
 2-222 1.37e-18

phosphatidic acid phosphatase family protein


Pssm-ID: 215288  Cd Length: 352  Bit Score: 84.02  E-value: 1.37e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003701506   2 YIGQVAKDVLKWPRPSSPPV-----VKLEKRLIAEYGMPSTHAMAATAIAFTLLISTMDRYQYP----FVLGLVMAVVFS 72
Cdd:PLN02525   49 YVGNCIKDVVSAPRPSCPPVrrvtaTKDEEENAMEYGLPSSHTLNTVCLSGYLLHYVLSYLQNVdasvIFAGLALFCLLV 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003701506  73 TLVCLSRLYTGMHTVLDVLGGVLITALLIVLtypaWTFIDC-LDS-------ASPLFpvcvIVVPFFLCYNYPVSDYYSP 144
Cdd:PLN02525  129 ALVGFGRLYLGMHSPIDIIAGLAIGLVILAF----WLTVDEyVDAfitsgqnVTPFW----AALSFLLLFAYPTPEFPTP 200

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1003701506 145 TRADTTTILAAGAGVTIGfwINHFFQlvSKPAESLPVIQNiPPLTTYMLvlgLTKFAVGIVLILLVRQLVQNLSLQVL 222
Cdd:PLN02525  201 SFEYHTAFNGVAFGIVAG--VQQTYS--QFHHEAAPRIFS-PQLPIAAF---LGRVAVGIPTILAVKFCSKALAKWLL 270
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 3-105 1.72e-14

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 68.26  E-value: 1.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003701506   3 IGQVAKDVLKWPRPSSPPVVKLEKRLI----AEYGMPSTHAMAATAIAFTLLISTMDRYQYPFVLGLvmAVVFSTLVCLS 78
Cdd:cd01610    18 LTGVLKYLFGRPRPYFLLRCGPDGDPLllteGGYSFPSGHAAFAFALALFLALLLPRRLLRLLLGLL--LLLLALLVGLS 95

                          90       100
                  ....*....|....*....|....*..
gi 1003701506  79 RLYTGMHTVLDVLGGVLITALLIVLTY 105
Cdd:cd01610    96 RVYLGVHYPSDVLAGALLGILVALLVL 122
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 1-105 6.07e-13

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 63.98  E-value: 6.07e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003701506   1 MYIGQVAKDVLKWPRPS-----SPPVVKLEKRLIAEYGMPSTHAMAATAIAFTLLISTMDRYQYPFVLGLVMAVVFSTLV 75
Cdd:pfam01569  10 GLLSSVLKDYFGRPRPFfllleGGLVPAPSTLPGLGYSFPSGHSATAFALALLLALLLRRLRKIVRVLLALLLLVLALLV 89

                          90       100       110
                  ....*....|....*....|....*....|
gi 1003701506  76 CLSRLYTGMHTVLDVLGGVLITALLIVLTY 105
Cdd:pfam01569  90 GLSRLYLGVHFPSDVLAGALIGILLALLVY 119
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 6-108 5.71e-10

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 57.36  E-value: 5.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003701506   6 VAKDVLKWPRPSSPPVVKLEKRLIAEYGMPSTHAMAATAIAFTLListmdrYQYPFVLGLVMAVVFSTLVCLSRLYTGMH 85
Cdd:COG0671    91 LLKYLFGRPRPFVVPDLELLLGTAGGYSFPSGHAAAAFALALVLA------LLLPRRWLAALLLALALLVGLSRVYLGVH 164

                          90       100
                  ....*....|....*....|...
gi 1003701506  86 TVLDVLGGVLITALLIVLTYPAW 108
Cdd:COG0671   165 YPSDVLAGALLGLAIALLLLALL 187
PAP2_like_3 cd03393
PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 2-103 5.29e-09

PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239487 [Multi-domain]  Cd Length: 125  Bit Score: 53.14  E-value: 5.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003701506   2 YIGQVAKDVLKWPRPSSPPVVKLEKRLIAE-YGMPSTHAMAATAIAFTLLISTMDRYQYPFvlglvmAVVFSTLVCLSRL 80
Cdd:cd03393    27 YLNAALKEVFKIPRPFTYDGIQAIYEESAGgYGFPSGHAQTSATFWGSLMLHVRKKWFTLI------GVVLVVLISFSRL 100

                          90       100
                  ....*....|....*....|...
gi 1003701506  81 YTGMHTVLDVLGGVLITALLIVL 103
Cdd:cd03393   101 YLGVHWPSDVIGGVLIGLLVLVL 123
acidPPc smart00014
Acid phosphatase homologues;
1-105 2.01e-08

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 51.19  E-value: 2.01e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003701506    1 MYIGQVAKDVLKW----PRP------SSPPVVKLEKRLIAEYGMPSTHAMAATAIAFTLLISTMDRYQYPFVLGLVMAVV 70
Cdd:smart00014   4 AVVSQLFNGVIKNyfgrPRPfflsigDACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYLPARAGRKLLIFLLLLLA 83

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1003701506   71 FstLVCLSRLYTGMHTVLDVLGGVLITALLIVLTY 105
Cdd:smart00014  84 L--VVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 6-100 6.96e-07

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 48.04  E-value: 6.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003701506   6 VAKDVLKWPRPSSPpvvklEKRLIAEYGMPSTHA--MAATAIAFTLLISTMDRYQYPFVLGLVMAVVF---STLVCLSRL 80
Cdd:cd03382    60 VLKRIIKEPRPCSG-----AYFVRSGYGMPSSHSqfMGFFAVYLLLFIYLRLGRLNSLVSRFLLSLGLlllALLVSYSRV 134

                          90       100
                  ....*....|....*....|
gi 1003701506  81 YTGMHTVLDVLGGVLITALL 100
Cdd:cd03382   135 YLGYHTVSQVVVGAIVGILL 154
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 3-107 7.37e-06

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 45.29  E-value: 7.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003701506   3 IGQVAKDVLKWPRPSSPPVVklekrLIAEYGMPSTHAMAATAIAFTLLI-----STMDRYQYPFVLGLVMAVVfstLVCL 77
Cdd:cd03392    77 LNTLLKLLVQRPRPPLHLLV-----PEGGYSFPSGHAMGATVLYGFLAYllarrLPRRRVRILLLILAAILIL---LVGL 148

                          90       100       110
                  ....*....|....*....|....*....|
gi 1003701506  78 SRLYTGMHTVLDVLGGVLITALLIVLTYPA 107
Cdd:cd03392   149 SRLYLGVHYPSDVLAGWLLGLAWLALLILL 178
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 6-111 1.90e-05

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 44.18  E-value: 1.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003701506   6 VAKDVLKWPRPSSPPVVKLEKRLIAE---YGMPSTHAMAATAIAFTLLIStmdryqYPFVLGLVMAVVFSTLVCLSRLYT 82
Cdd:cd03395    75 FLKPLVARLRPCNALDGVRLVVLGDQggsYSFASSHAANSFALALFIWLF------FRRGLFSPVLLLWALLVGYSRVYV 148

                          90       100
                  ....*....|....*....|....*....
gi 1003701506  83 GMHTVLDVLGGVLITALLIVLTYPAWTFI 111
Cdd:cd03395   149 GVHYPGDVIAGALIGIISGLLFYLLFSWL 177
PAP2_BcrC_like cd03385
PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as ...
 14-99 7.20e-05

PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from Bacillus subtilis posesses undecaprenyl pyrophosphate (UPP) phospatase activity, and it is hypothesized that it competes with bacitracin for UPP, increasing the cell's resistance to bacitracin.


Pssm-ID: 239480  Cd Length: 144  Bit Score: 41.86  E-value: 7.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003701506  14 PRPSSPPVVKLEKRLIAEYGMPSTHAMAATAIAFTLLIStmdRYQYPFVLGLVMAVvfstLVCLSRLYTGMHTVLDVLGG 93
Cdd:cd03385    59 PRPFVVGLGHNLLPHAADSSFPSDHTTLFFSIAFSLLLR---RRKWAGWILLILAL----LVAWSRIYLGVHYPLDMLGA 131


                  ....*.
gi 1003701506  94 VLITAL 99
Cdd:cd03385   132 ALVAVL 137
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 33-106 1.62e-03

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 38.46  E-value: 1.62e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1003701506  33 GMPSTHAMAATAIAFTLLIsTMDRYQYPFVLGLVmavvfstLVCLSRLYTGMHTVLDVLGGVLITALLIVLTYP 106
Cdd:cd03389   119 SFPSGHSATAGAAAAALAL-LFPRYRWAFILLAL-------LIAFSRVIVGAHYPSDVIAGSLLGAVTALALYQ 184
PAP2_diacylglycerolkinase cd03383
PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like ...
 33-103 2.20e-03

PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be determined.


Pssm-ID: 239478 [Multi-domain]  Cd Length: 109  Bit Score: 36.92  E-value: 2.20e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1003701506  33 GMPSTHAMAATAIAFTLLISTMDryqyPFVLGLVMAVVFstLVCLSRLYTGMHTVLDVLGGVLITALLIVL 103
Cdd:cd03383    40 GMPSGHAAIAFSIATAISLITNN----PIISILSVLLAV--MVAHSRVEMKIHTMWEVVVGAILGALITLL 104
PAP2_3 pfam14378
PAP2 superfamily;
34-103 6.15e-03

PAP2 superfamily;


Pssm-ID: 433919  Cd Length: 190  Bit Score: 36.93  E-value: 6.15e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003701506  34 MPSTHAmaATAIAFTLLISTMDRYQYPFVLGLVMAVvfstLVCLSRLYTGMHTVLDVLGGVLITALLIVL 103
Cdd:pfam14378 127 MPSLHV--AWALLCALALWRLRRTRILRWLAVAYNV----LMIVSTVATGNHYLLDVVAGVALALAAIAL 190
PRK10699 PRK10699
phosphatidylglycerophosphatase B; Provisional
 32-103 7.25e-03

phosphatidylglycerophosphatase B; Provisional


Pssm-ID: 182658  Cd Length: 244  Bit Score: 36.93  E-value: 7.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1003701506  32 YGMPSTHAM-AAT--AIAFTLListMDRYQYPFVlglVMAVVFSTLVCLSRLYTGMHTVLDVLGGVLITALLIVL 103
Cdd:PRK10699  157 FAFPSGHTMfAASwaLLAVGLL---WPRRRYKTV---ALLMLWATGVMGSRLLLGMHWPRDLVVATLISWLLVTV 225
PRK09597 PRK09597
lipid A 1-phosphatase LpxE;
30-103 7.32e-03

lipid A 1-phosphatase LpxE;


Pssm-ID: 181978  Cd Length: 190  Bit Score: 36.79  E-value: 7.32e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1003701506  30 AEYGMPSTHA-MAATAIAFTllistMDRYQYPFVLGLVMAVVfstLVCLSRLYTGMHTVLDVLGGVLITALLIVL 103
Cdd:PRK09597  117 GNFNMPSGHSsMVGLAVAFL-----MRRYSFKKYWWLLPLIP---LTMLARIYLDMHTIGAVLAGLGVGMLCVSL 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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