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Conserved domains on  [gi|1012443756|ref|NP_001308754|]
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fidgetin isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 476-639 2.70e-104

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


:

Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 316.06  E-value: 2.70e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 476 DIAGLDLVKAVIKEEVLWPVLRSDAFSGLTALPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEAEKI 555
Cdd:cd19523     1 DIAGLGALKAAIKEEVLWPLLRPDAFSGLLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 556 IHASFLVARCRQPSVIFVSDIDMLLSSQVnEEHSPVSRMRTEFLMQLDTVLTSAEDQIVVICATSKPEEIDESLRRYFMK 635
Cdd:cd19523    81 LQASFLAARCRQPSVLFISDLDALLSSQD-DEASPVGRLQVELLAQLDGVLGSGEDGVLVVCTTSKPEEIDESLRRYFSK 159


                  ....
gi 1012443756 636 RLLI 639
Cdd:cd19523   160 RLLV 163
Vps4_C super family cl07827
Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase ...
 712-745 1.17e-05

Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase proteins involved in vacuolar sorting. It forms an alpha helix structure and is required for oligomerization.


The actual alignment was detected with superfamily member pfam09336:

Pssm-ID: 462762 [Multi-domain]  Cd Length: 61  Bit Score: 43.25  E-value: 1.17e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1012443756 712 PVTYQDFENAFCKIQPSISQKELDMYVEWNKMFG 745
Cdd:pfam09336  28 PVTMKDFLKALKSSRPTVSKEDLEKYEEFTKEFG 61
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 664-695 1.30e-03

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


:

Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 37.13  E-value: 1.30e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1012443756 664 DKEFALLVQRTEGFSGLDVAHLCQEAVVGPLH 695
Cdd:pfam17862   1 DVDLEELAERTEGFSGADLEALCREAALAALR 32
 
Name Accession Description Interval E-value
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 476-639 2.70e-104

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 316.06  E-value: 2.70e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 476 DIAGLDLVKAVIKEEVLWPVLRSDAFSGLTALPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEAEKI 555
Cdd:cd19523     1 DIAGLGALKAAIKEEVLWPLLRPDAFSGLLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 556 IHASFLVARCRQPSVIFVSDIDMLLSSQVnEEHSPVSRMRTEFLMQLDTVLTSAEDQIVVICATSKPEEIDESLRRYFMK 635
Cdd:cd19523    81 LQASFLAARCRQPSVLFISDLDALLSSQD-DEASPVGRLQVELLAQLDGVLGSGEDGVLVVCTTSKPEEIDESLRRYFSK 159


                  ....
gi 1012443756 636 RLLI 639
Cdd:cd19523   160 RLLV 163
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 470-732 5.39e-54

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 189.06  E-value: 5.39e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 470 PPVDWNDIAGLDLVKAVIKEEVLWPVLRSDAFS--GLTAlPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAK 547
Cdd:COG1222    73 PDVTFDDIGGLDEQIEEIREAVELPLKNPELFRkyGIEP-PKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSK 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 548 WLGEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQVNE-EHSPVSRMRTEFLMQLDTVltSAEDQIVVICATSKPEEID 626
Cdd:COG1222   152 YIGEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDgTSGEVQRTVNQLLAELDGF--ESRGDVLIIAATNRPDLLD 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 627 ESLRRY--FMKRLLIPLPDSTARHQIIvQLLSQHNYCLNDKEFALLVQRTEGFSGLDVAHLCQEAvvgplhAMpatdlSA 704
Cdd:COG1222   230 PALLRPgrFDRVIEVPLPDEEAREEIL-KIHLRDMPLADDVDLDKLAKLTEGFSGADLKAIVTEA------GM-----FA 297

                         250       260
                  ....*....|....*....|....*...
gi 1012443756 705 IMpSQLRPVTYQDFENAFCKIQPSISQK 732
Cdd:COG1222   298 IR-EGRDTVTMEDLEKAIEKVKKKTETA 324
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 464-745 4.61e-45

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 172.78  E-value: 4.61e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 464 EIITQGPPVDWNDIAGLDLVKAVIKEEVLWPVLRSDAFS--GLTAlPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAG 541
Cdd:TIGR01243 442 EVLVEVPNVRWSDIGGLEEVKQELREAVEWPLKHPEIFEkmGIRP-PKGVLLFGPPGTGKTLLAKAVATESGANFIAVRG 520

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 542 SGLVAKWLGEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQVNEEHSPVS-RMRTEFLMQLDTVLTSAEdqIVVICATS 620
Cdd:TIGR01243 521 PEILSKWVGESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDTSVTdRIVNQLLTEMDGIQELSN--VVVIAATN 598

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 621 KPEEIDESLRR--YFMKRLLIPLPDSTARHQIivqlLSQHNYCLN---DKEFALLVQRTEGFSGLDVAHLCQEAVVGPLH 695
Cdd:TIGR01243 599 RPDILDPALLRpgRFDRLILVPPPDEEARKEI----FKIHTRSMPlaeDVDLEELAEMTEGYTGADIEAVCREAAMAALR 674

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1012443756 696 ----AMPATDLSAIMPSQLRP--VTYQDFENAFCKIQPSISQKELDMYVEWNKMFG 745
Cdd:TIGR01243 675 esigSPAKEKLEVGEEEFLKDlkVEMRHFLEALKKVKPSVSKEDMLRYERLAKELK 730
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 464-745 2.37e-35

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 138.43  E-value: 2.37e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 464 EIITQgPPVDWNDIAGLDLVKAVIKEEVLWPVLRSDAFS--GLTAlPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAG 541
Cdd:PRK03992  121 EVIES-PNVTYEDIGGLEEQIREVREAVELPLKKPELFEevGIEP-PKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVG 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 542 SGLVAKWLGEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQVNEEHSPvSR--MRTefLMQLdtvLtsAE-------DQ 612
Cdd:PRK03992  199 SELVQKFIGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRTDSGTSG-DRevQRT--LMQL---L--AEmdgfdprGN 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 613 IVVICATSKPEEIDESLRR--YFmKRLL-IPLPDSTARHQIivqlLSQHNYCLN---DKEFALLVQRTEGFSGLDVAHLC 686
Cdd:PRK03992  271 VKIIAATNRIDILDPAILRpgRF-DRIIeVPLPDEEGRLEI----LKIHTRKMNladDVDLEELAELTEGASGADLKAIC 345

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1012443756 687 QEAvvgplhAMPAtdlsaimpsqLRP----VTYQDFENAFCKIQpsiSQKELDMYVEWNKMFG 745
Cdd:PRK03992  346 TEA------GMFA----------IRDdrteVTMEDFLKAIEKVM---GKEEKDSMEEPGVMFA 389
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 511-641 1.60e-33

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 125.01  E-value: 1.60e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 511 ILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQVNEEHSP 590
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1012443756 591 VSRMRTEFLMQLDTVlTSAEDQIVVICATSKPEEIDESLRRYFMKRLLIPL 641
Cdd:pfam00004  81 SRRVVNQLLTELDGF-TSSNSKVIVIAATNRPDKLDPALLGRFDRIIEFPL 130
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 508-643 7.39e-10

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 58.15  E-value: 7.39e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756  508 PRSILLFGPRGTGKTLLGRCIASQLGAT---FFKIAGSGLVAKWLGEAEKIIHASF------------LVARCRQ--PSV 570
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPgggVIYIDGEDILEEVLDQLLLIIVGGKkasgsgelrlrlALALARKlkPDV 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1012443756  571 IFVSDIDMLLSSQVNEEHSPVSRMRTEFLMQLdtvltsaEDQIVVICATSKPEEIDES-LRRYFMKRLLIPLPD 643
Cdd:smart00382  82 LILDEITSLLDAEQEALLLLLEELRLLLLLKS-------EKNLTVILTTNDEKDLGPAlLRRRFDRRIVLLLIL 148
Vps4_C pfam09336
Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase ...
 712-745 1.17e-05

Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase proteins involved in vacuolar sorting. It forms an alpha helix structure and is required for oligomerization.


Pssm-ID: 462762 [Multi-domain]  Cd Length: 61  Bit Score: 43.25  E-value: 1.17e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1012443756 712 PVTYQDFENAFCKIQPSISQKELDMYVEWNKMFG 745
Cdd:pfam09336  28 PVTMKDFLKALKSSRPTVSKEDLEKYEEFTKEFG 61
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 664-695 1.30e-03

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 37.13  E-value: 1.30e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1012443756 664 DKEFALLVQRTEGFSGLDVAHLCQEAVVGPLH 695
Cdd:pfam17862   1 DVDLEELAERTEGFSGADLEALCREAALAALR 32
 
Name Accession Description Interval E-value
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 476-639 2.70e-104

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 316.06  E-value: 2.70e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 476 DIAGLDLVKAVIKEEVLWPVLRSDAFSGLTALPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEAEKI 555
Cdd:cd19523     1 DIAGLGALKAAIKEEVLWPLLRPDAFSGLLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 556 IHASFLVARCRQPSVIFVSDIDMLLSSQVnEEHSPVSRMRTEFLMQLDTVLTSAEDQIVVICATSKPEEIDESLRRYFMK 635
Cdd:cd19523    81 LQASFLAARCRQPSVLFISDLDALLSSQD-DEASPVGRLQVELLAQLDGVLGSGEDGVLVVCTTSKPEEIDESLRRYFSK 159


                  ....
gi 1012443756 636 RLLI 639
Cdd:cd19523   160 RLLV 163
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 477-639 6.16e-87

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 271.15  E-value: 6.16e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 477 IAGLDLVKAVIKEEVLWPVLRSDAFSGLTALPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEAEKII 556
Cdd:cd19509     1 IAGLDDAKEALKEAVILPSLRPDLFPGLRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKIV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 557 HASFLVARCRQPSVIFVSDIDMLLSSQVNEEHSPVSRMRTEFLMQLDTVLTSAEDQIVVICATSKPEEIDESLRRYFMKR 636
Cdd:cd19509    81 RALFALARELQPSIIFIDEIDSLLSERGSGEHEASRRVKTEFLVQMDGVLNKPEDRVLVLGATNRPWELDEAFLRRFEKR 160


                  ...
gi 1012443756 637 LLI 639
Cdd:cd19509   161 IYI 163
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 454-639 3.85e-78

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 248.75  E-value: 3.85e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 454 DTHLIDLVTNEIITQGPPVDWNDIAGLDLVKAVIKEEVLWPVLRSDAFSGLTALPRSILLFGPRGTGKTLLGRCIASQLG 533
Cdd:cd19525     1 EPKMIELIMSEIMDHGPPINWADIAGLEFAKKTIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 534 ATFFKIAGSGLVAKWLGEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQVNEEHSPVSRMRTEFLMQLDTVLTSAEDQI 613
Cdd:cd19525    81 ATFFSISASSLTSKWVGEGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGEGEHESSRRIKTEFLVQLDGATTSSEDRI 160

                         170       180
                  ....*....|....*....|....*.
gi 1012443756 614 VVICATSKPEEIDESLRRYFMKRLLI 639
Cdd:cd19525   161 LVVGATNRPQEIDEAARRRLVKRLYI 186
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 470-732 5.39e-54

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 189.06  E-value: 5.39e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 470 PPVDWNDIAGLDLVKAVIKEEVLWPVLRSDAFS--GLTAlPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAK 547
Cdd:COG1222    73 PDVTFDDIGGLDEQIEEIREAVELPLKNPELFRkyGIEP-PKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSK 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 548 WLGEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQVNE-EHSPVSRMRTEFLMQLDTVltSAEDQIVVICATSKPEEID 626
Cdd:COG1222   152 YIGEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDgTSGEVQRTVNQLLAELDGF--ESRGDVLIIAATNRPDLLD 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 627 ESLRRY--FMKRLLIPLPDSTARHQIIvQLLSQHNYCLNDKEFALLVQRTEGFSGLDVAHLCQEAvvgplhAMpatdlSA 704
Cdd:COG1222   230 PALLRPgrFDRVIEVPLPDEEAREEIL-KIHLRDMPLADDVDLDKLAKLTEGFSGADLKAIVTEA------GM-----FA 297

                         250       260
                  ....*....|....*....|....*...
gi 1012443756 705 IMpSQLRPVTYQDFENAFCKIQPSISQK 732
Cdd:COG1222   298 IR-EGRDTVTMEDLEKAIEKVKKKTETA 324
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 476-639 1.08e-51

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 176.96  E-value: 1.08e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 476 DIAGLDLVKAVIKEEVLWPVLRSDAFSGLTALPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEAEKI 555
Cdd:cd19524     1 DIAGQDLAKQALQEMVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 556 IHASFLVARCRQPSVIFVSDIDMLLSSQVNEEHSPVSRMRTEFLMQLDTVLTSAEDQIVVICATSKPEEIDESLRRYFMK 635
Cdd:cd19524    81 VRALFAVARELQPSIIFIDEVDSLLSERSEGEHEASRRLKTEFLIEFDGVQSNGDDRVLVMGATNRPQELDDAVLRRFTK 160


                  ....
gi 1012443756 636 RLLI 639
Cdd:cd19524   161 RVYV 164
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 474-721 4.89e-48

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 174.71  E-value: 4.89e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 474 WNDIAGLDLVKAVIKEEVLWPVLRSDAFS--GLTaLPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGE 551
Cdd:COG0464   156 LDDLGGLEEVKEELRELVALPLKRPELREeyGLP-PPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGE 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 552 AEKIIHASFLVARCRQPSVIFVSDIDMLLSSQVNEEHSPVSRMRTEFLMQLDTVltsaEDQIVVICATSKPEEIDESLRR 631
Cdd:COG0464   235 TEKNLREVFDKARGLAPCVLFIDEADALAGKRGEVGDGVGRRVVNTLLTEMEEL----RSDVVVIAATNRPDLLDPALLR 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 632 YFMKRLLIPLPDSTARHQIIVQLLSQHNYClNDKEFALLVQRTEGFSGLDVAHLCQEAVvgpLHAMPATDlsaimpsqlR 711
Cdd:COG0464   311 RFDEIIFFPLPDAEERLEIFRIHLRKRPLD-EDVDLEELAEATEGLSGADIRNVVRRAA---LQALRLGR---------E 377

                         250
                  ....*....|
gi 1012443756 712 PVTYQDFENA 721
Cdd:COG0464   378 PVTTEDLLEA 387
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 464-745 4.61e-45

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 172.78  E-value: 4.61e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 464 EIITQGPPVDWNDIAGLDLVKAVIKEEVLWPVLRSDAFS--GLTAlPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAG 541
Cdd:TIGR01243 442 EVLVEVPNVRWSDIGGLEEVKQELREAVEWPLKHPEIFEkmGIRP-PKGVLLFGPPGTGKTLLAKAVATESGANFIAVRG 520

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 542 SGLVAKWLGEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQVNEEHSPVS-RMRTEFLMQLDTVLTSAEdqIVVICATS 620
Cdd:TIGR01243 521 PEILSKWVGESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDTSVTdRIVNQLLTEMDGIQELSN--VVVIAATN 598

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 621 KPEEIDESLRR--YFMKRLLIPLPDSTARHQIivqlLSQHNYCLN---DKEFALLVQRTEGFSGLDVAHLCQEAVVGPLH 695
Cdd:TIGR01243 599 RPDILDPALLRpgRFDRLILVPPPDEEARKEI----FKIHTRSMPlaeDVDLEELAEMTEGYTGADIEAVCREAAMAALR 674

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1012443756 696 ----AMPATDLSAIMPSQLRP--VTYQDFENAFCKIQPSISQKELDMYVEWNKMFG 745
Cdd:TIGR01243 675 esigSPAKEKLEVGEEEFLKDlkVEMRHFLEALKKVKPSVSKEDMLRYERLAKELK 730
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 470-639 4.41e-43

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 153.48  E-value: 4.41e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 470 PPVDWNDIAGLDLVKAVIKEEVLWPVLRSDAFSGLTALPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWL 549
Cdd:cd19521     2 PNVKWEDVAGLEGAKEALKEAVILPVKFPHLFTGNRKPWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWM 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 550 GEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQVNEEHSPVSRMRTEFLMQLDTVlTSAEDQIVVICATSKPEEIDESL 629
Cdd:cd19521    82 GESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRGEGESEASRRIKTELLVQMNGV-GNDSQGVLVLGATNIPWQLDSAI 160

                         170
                  ....*....|
gi 1012443756 630 RRYFMKRLLI 639
Cdd:cd19521   161 RRRFEKRIYI 170
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 476-639 1.99e-42

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 151.42  E-value: 1.99e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 476 DIAGLDLVKAVIKEEVLWPVLRSDAF--SGLTALPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEAE 553
Cdd:cd19520     1 DIGGLDEVITELKELVILPLQRPELFdnSRLLQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 554 KIIHASFLVARCRQPSVIFVSDIDMLLSSQVNEEHSPVSRMRTEFLMQLDTVLTSAEDQIVVICATSKPEEIDESLRRYF 633
Cdd:cd19520    81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQRSSTDHEATAMMKAEFMSLWDGLSTDGNCRVIVMGATNRPQDLDEAILRRM 160


                  ....*.
gi 1012443756 634 MKRLLI 639
Cdd:cd19520   161 PKRFHI 166
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 476-639 1.36e-38

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 140.89  E-value: 1.36e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 476 DIAGLDLVKAVIKEEVLWPVLRSDAFSGLTALPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEAEKI 555
Cdd:cd19522     1 DIADLEEAKKLLEEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESEKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 556 IHASFLVARCRQPSVIFVSDIDMLLSSQ-VNEEHSPVSRMRTEFLMQLDTVLTSAEDQ-----IVVICATSKPEEIDESL 629
Cdd:cd19522    81 VRLLFEMARFYAPTTIFIDEIDSICSRRgTSEEHEASRRVKSELLVQMDGVGGASENDdpskmVMVLAATNFPWDIDEAL 160

                         170
                  ....*....|
gi 1012443756 630 RRYFMKRLLI 639
Cdd:cd19522   161 RRRLEKRIYI 170
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 464-745 2.37e-35

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 138.43  E-value: 2.37e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 464 EIITQgPPVDWNDIAGLDLVKAVIKEEVLWPVLRSDAFS--GLTAlPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAG 541
Cdd:PRK03992  121 EVIES-PNVTYEDIGGLEEQIREVREAVELPLKKPELFEevGIEP-PKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVG 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 542 SGLVAKWLGEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQVNEEHSPvSR--MRTefLMQLdtvLtsAE-------DQ 612
Cdd:PRK03992  199 SELVQKFIGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRTDSGTSG-DRevQRT--LMQL---L--AEmdgfdprGN 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 613 IVVICATSKPEEIDESLRR--YFmKRLL-IPLPDSTARHQIivqlLSQHNYCLN---DKEFALLVQRTEGFSGLDVAHLC 686
Cdd:PRK03992  271 VKIIAATNRIDILDPAILRpgRF-DRIIeVPLPDEEGRLEI----LKIHTRKMNladDVDLEELAELTEGASGADLKAIC 345

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1012443756 687 QEAvvgplhAMPAtdlsaimpsqLRP----VTYQDFENAFCKIQpsiSQKELDMYVEWNKMFG 745
Cdd:PRK03992  346 TEA------GMFA----------IRDdrteVTMEDFLKAIEKVM---GKEEKDSMEEPGVMFA 389
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 511-641 1.60e-33

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 125.01  E-value: 1.60e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 511 ILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQVNEEHSP 590
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1012443756 591 VSRMRTEFLMQLDTVlTSAEDQIVVICATSKPEEIDESLRRYFMKRLLIPL 641
Cdd:pfam00004  81 SRRVVNQLLTELDGF-TSSNSKVIVIAATNRPDKLDPALLGRFDRIIEFPL 130
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 476-631 1.63e-33

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 126.25  E-value: 1.63e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 476 DIAGLDLVKAVIKEEVLWPVLRSDAFS--GLTAlPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEAE 553
Cdd:cd19503     1 DIGGLDEQIASLKELIELPLKYPELFRalGLKP-PRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESE 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1012443756 554 KIIHASFLVARCRQPSVIFVSDIDMLLSSQVNEEHSPVSRMRTEFLMQLDTVltSAEDQIVVICATSKPEEIDESLRR 631
Cdd:cd19503    80 KNLREIFEEARSHAPSIIFIDEIDALAPKREEDQREVERRVVAQLLTLMDGM--SSRGKVVVIAATNRPDAIDPALRR 155
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 483-631 3.89e-33

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 125.09  E-value: 3.89e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 483 VKAVIKEEVLWPVLRSDAFS--GLTaLPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEAEKIIHASF 560
Cdd:cd19511     1 VKRELKEAVEWPLKHPDAFKrlGIR-PPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIF 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1012443756 561 LVARCRQPSVIFVSDIDMLLSSQVNEEHSPVS-RMRTEFLMQLDTVltSAEDQIVVICATSKPEEIDESLRR 631
Cdd:cd19511    80 QKARQAAPCIIFFDEIDSLAPRRGQSDSSGVTdRVVSQLLTELDGI--ESLKGVVVIAATNRPDMIDPALLR 149
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 452-739 6.02e-33

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 135.80  E-value: 6.02e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 452 NTDTHLIDLVTNEIITQG-PPVDWNDIAGLDLVKAVIKEEVLWPVLRSDAFSGL-TALPRSILLFGPRGTGKTLLGRCIA 529
Cdd:TIGR01243 154 ATEVEIREKPVREEIERKvPKVTYEDIGGLKEAKEKIREMVELPMKHPELFEHLgIEPPKGVLLYGPPGTGKTLLAKAVA 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 530 SQLGATFFKIAGSGLVAKWLGEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQVNEEHSPVSRMRTEFLMQLDTVltSA 609
Cdd:TIGR01243 234 NEAGAYFISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVTGEVEKRVVAQLLTLMDGL--KG 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 610 EDQIVVICATSKPEEIDESLRR--YFMKRLLIPLPDSTARHQIIvQLLSQHNYCLNDKEFALLVQRTEGFSGLDVAHLCQ 687
Cdd:TIGR01243 312 RGRVIVIGATNRPDALDPALRRpgRFDREIVIRVPDKRARKEIL-KVHTRNMPLAEDVDLDKLAEVTHGFVGADLAALAK 390

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 688 EAVVGPLHAM--------PATDLSAIMPSQLRpVTYQDFENAFCKIQPSISQkelDMYVE 739
Cdd:TIGR01243 391 EAAMAALRRFiregkinfEAEEIPAEVLKELK-VTMKDFMEALKMVEPSAIR---EVLVE 446
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 483-631 7.77e-32

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 121.24  E-value: 7.77e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 483 VKAVIKEEVLWPVLRSDAFSGLTALPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEAEKIIHASFLV 562
Cdd:cd19481     1 LKASLREAVEAPRRGSRLRRYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFER 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 563 ARCRQPSVIFVSDIDMLLSSQVNEEHSPV-SRMRTEFLMQLDTVltSAEDQIVVICATSKPEEIDESLRR 631
Cdd:cd19481    81 ARRLAPCILFIDEIDAIGRKRDSSGESGElRRVLNQLLTELDGV--NSRSKVLVIAATNRPDLLDPALLR 148
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
474-711 6.85e-31

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 121.53  E-value: 6.85e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 474 WNDIAGLDLVKA----VIKEEVLWPVLRSdafSGLTAlPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWL 549
Cdd:COG1223     1 LDDVVGQEEAKKklklIIKELRRRENLRK---FGLWP-PRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 550 GEAEKIIHASFLVARcRQPSVIFVSDIDML-LSSQVNEEHSPVSRMRTEFLMQLDTVltsaEDQIVVICATSKPEEIDES 628
Cdd:COG1223    77 GETARNLRKLFDFAR-RAPCVIFFDEFDAIaKDRGDQNDVGEVKRVVNALLQELDGL----PSGSVVIAATNHPELLDSA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 629 LRRYFMKRLLIPLPDSTARHQIIVQLLSQHnYCLNDKEFALLVQRTEGFSGLDVAHLCQEAVvgplHAMPATDLSAIMPS 708
Cdd:COG1223   152 LWRRFDEVIEFPLPDKEERKEILELNLKKF-PLPFELDLKKLAKKLEGLSGADIEKVLKTAL----KKAILEDREKVTKE 226


                  ...
gi 1012443756 709 QLR 711
Cdd:COG1223   227 DLE 229
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 483-631 1.12e-29

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 115.29  E-value: 1.12e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 483 VKAVIKEEVLWPVLRSDAF--SGLTAlPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEAEKIIHASF 560
Cdd:cd19529     1 VKQELKEAVEWPLLKPEVFkrLGIRP-PKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIF 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1012443756 561 LVARCRQPSVIFVSDIDMLLSSQVNEEHSPVS-RMRTEFLMQLDTvLTSAEDqIVVICATSKPEEIDESLRR 631
Cdd:cd19529    80 RKARQVAPCVIFFDEIDSIAPRRGTTGDSGVTeRVVNQLLTELDG-LEEMNG-VVVIAATNRPDIIDPALLR 149
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 473-631 1.43e-29

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 115.13  E-value: 1.43e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 473 DWNDIAGLDLVKAVIKEEVLWPVLRSDAFSGL-TALPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGE 551
Cdd:cd19502     1 TYEDIGGLDEQIREIREVVELPLKHPELFEELgIEPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 552 AEKIIHASFLVARCRQPSVIFVSDIDMLLSSQVNEEHS---PVSRMRTEFLMQLDTVltSAEDQIVVICATSKPEEIDES 628
Cdd:cd19502    81 GARLVRELFEMAREKAPSIIFIDEIDAIGAKRFDSGTGgdrEVQRTMLELLNQLDGF--DPRGNIKVIMATNRPDILDPA 158


                  ...
gi 1012443756 629 LRR 631
Cdd:cd19502   159 LLR 161
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 466-737 1.34e-28

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 118.71  E-value: 1.34e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 466 ITQGPPVDWNDIAGLDLVKAVIKEEVLWPVLRSDAFS--GLTAlPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSG 543
Cdd:PTZ00454  136 MSEKPDVTYSDIGGLDIQKQEIREAVELPLTCPELYEqiGIDP-PRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSE 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 544 LVAKWLGEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQVNEEHSP---VSRMRTEFLMQLDTVltsaeDQIV---VIC 617
Cdd:PTZ00454  215 FVQKYLGEGPRMVRDVFRLARENAPSIIFIDEVDSIATKRFDAQTGAdreVQRILLELLNQMDGF-----DQTTnvkVIM 289

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 618 ATSKPEEIDESLRR--YFMKRLLIPLPDSTARHQIIVQLLSQHNYClNDKEFALLVQRTEGFSGLDVAHLCQEAvvgplh 695
Cdd:PTZ00454  290 ATNRADTLDPALLRpgRLDRKIEFPLPDRRQKRLIFQTITSKMNLS-EEVDLEDFVSRPEKISAADIAAICQEA------ 362

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1012443756 696 AMPATDLSAIMpsqlrpVTYQDFENAFcKIQPSISQKELDMY 737
Cdd:PTZ00454  363 GMQAVRKNRYV------ILPKDFEKGY-KTVVRKTDRDYDFY 397
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 476-632 8.34e-26

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 104.44  E-value: 8.34e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 476 DIAGLDLVKAVIKEEVLWPVLRSDAFSGL-TALPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEAEK 554
Cdd:cd19519     1 DIGGCRKQLAQIREMVELPLRHPELFKAIgIKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESES 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 555 IIHASFLVARCRQPSVIFVSDIDMlLSSQVNEEHSPVSRmrtEFLMQLDTVL--TSAEDQIVVICATSKPEEIDESLRRY 632
Cdd:cd19519    81 NLRKAFEEAEKNAPAIIFIDEIDA-IAPKREKTHGEVER---RIVSQLLTLMdgLKQRAHVIVMAATNRPNSIDPALRRF 156
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 480-631 5.77e-25

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 101.80  E-value: 5.77e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 480 LDLVKAVIKEEVLWPVLRSDAFSGL-TALPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEAEKIIHA 558
Cdd:cd19530     1 LDHVREELTMSILRPIKRPDIYKALgIDLPTGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVRQ 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1012443756 559 SFLVARCRQPSVIFVSDIDMLLSSQVNEEHSPVSRMRTEFLMQLDTVltSAEDQIVVICATSKPEEIDESLRR 631
Cdd:cd19530    81 VFQRARASAPCVIFFDEVDALVPKRGDGGSWASERVVNQLLTEMDGL--EERSNVFVIAATNRPDIIDPAMLR 151
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 460-689 6.82e-24

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 105.24  E-value: 6.82e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 460 LVTNEIITQGPPVDWNDIAGLDLVKAVIKEEVLWPVLRSDAFS--GLTAlPRSILLFGPRGTGKTLLGRCIASQLGATFF 537
Cdd:PTZ00361  168 LVSVMKVDKAPLESYADIGGLEQQIQEIKEAVELPLTHPELYDdiGIKP-PKGVILYGPPGTGKTLLAKAVANETSATFL 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 538 KIAGSGLVAKWLGEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQVNEEHS---PVSRMRTEFLMQLDTVLTSAEdqIV 614
Cdd:PTZ00361  247 RVVGSELIQKYLGDGPKLVRELFRVAEENAPSIVFIDEIDAIGTKRYDATSGgekEIQRTMLELLNQLDGFDSRGD--VK 324

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1012443756 615 VICATSKPEEIDESLRR--YFMKRLLIPLPDSTARHQIIVQLLSQHNYClNDKEFALLVQRTEGFSGLDVAHLCQEA 689
Cdd:PTZ00361  325 VIMATNRIESLDPALIRpgRIDRKIEFPNPDEKTKRRIFEIHTSKMTLA-EDVDLEEFIMAKDELSGADIKAICTEA 400
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 476-631 2.24e-23

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 97.58  E-value: 2.24e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 476 DIAGLDLVKAVIKEEVLWPVLRSDAFSGLTALP-RSILLFGPRGTGKTLLGRCIASQLGA-----TFFKIAGSGLVAKWL 549
Cdd:cd19517     1 DIGGLSHYINQLKEMVFFPLLYPEVFAKFKITPpRGVLFHGPPGTGKTLMARALAAECSKggqkvSFFMRKGADCLSKWV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 550 GEAEKIIHASFLVARCRQPSVIFVSDIDMLL---SSQVNEEHSPVSRMRTEFLMQLDTvltsaEDQIVVICATSKPEEID 626
Cdd:cd19517    81 GEAERQLRLLFEEAYRMQPSIIFFDEIDGLApvrSSKQEQIHASIVSTLLALMDGLDN-----RGQVVVIGATNRPDALD 155


                  ....*
gi 1012443756 627 ESLRR 631
Cdd:cd19517   156 PALRR 160
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 483-631 8.83e-23

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 95.65  E-value: 8.83e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 483 VKAVIKEEVLWPVLRSDAFSGLTALP-RSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEAEKIIHASFL 561
Cdd:cd19528     1 VKRELQELVQYPVEHPDKFLKFGMTPsKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1012443756 562 VARCRQPSVIFVSDIDMLL---SSQVNEEHSPVSRMRTEFLMQLDTVltSAEDQIVVICATSKPEEIDESLRR 631
Cdd:cd19528    81 KARAAAPCVLFFDELDSIAkarGGNIGDAGGAADRVINQILTEMDGM--NTKKNVFIIGATNRPDIIDPAILR 151
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
431-691 2.84e-22

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 102.03  E-value: 2.84e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 431 MQGPGLRAATSSNHS-----VDEQLKNTdthlidlvtneiitqgppvdWNDIAGLDLVKAVIKEEVLWpvLRSDA-FSGL 504
Cdd:PRK10733  123 MQGGGGKGAMSFGKSkarmlTEDQIKTT--------------------FADVAGCDEAKEEVAELVEY--LREPSrFQKL 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 505 TA-LPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEAEKIIHASFLVARCRQPSVIFVSDIDML---L 580
Cdd:PRK10733  181 GGkIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVgrqR 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 581 SSQVNEEHSPVSRMRTEFLMQLDTVltSAEDQIVVICATSKPEEIDESLRR--YFMKRLLIPLPDSTARHQIIvQLLSQH 658
Cdd:PRK10733  261 GAGLGGGHDEREQTLNQMLVEMDGF--EGNEGIIVIAATNRPDVLDPALLRpgRFDRQVVVGLPDVRGREQIL-KVHMRR 337

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1012443756 659 NYCLNDKEFALLVQRTEGFSGLDVAHLCQEAVV 691
Cdd:PRK10733  338 VPLAPDIDAAIIARGTPGFSGADLANLVNEAAL 370
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 476-631 6.68e-22

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 93.24  E-value: 6.68e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 476 DIAGLDLVKAVIKEEVLWPVLRSDAFSGLTALP-RSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEAEK 554
Cdd:cd19518     1 DIGGMDSTLKELCELLIHPILPPEYFQHLGVEPpRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESEE 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1012443756 555 IIHASFLVARCRQPSVIFVSDIDMLLSSQVNEEHSPVSRMRTEFLMQLD--TVLTSAEDQIVVICATSKPEEIDESLRR 631
Cdd:cd19518    81 KIRELFDQAISNAPCIVFIDEIDAITPKRESAQREMERRIVSQLLTCMDelNNEKTAGGPVLVIGATNRPDSLDPALRR 159
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 483-631 2.45e-21

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 91.42  E-value: 2.45e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 483 VKAVIKEEVLWPVLRSDAFSGLTALPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEAEKIIHASFLV 562
Cdd:cd19527     1 VKKEILDTIQLPLEHPELFSSGLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQK 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1012443756 563 ARCRQPSVIFVSDIDMLLSSQVNEEHSP--VSRMRTEFLMQLDTVLTSAEDqIVVICATSKPEEIDESLRR 631
Cdd:cd19527    81 ARDAKPCVIFFDELDSLAPSRGNSGDSGgvMDRVVSQLLAELDGMSSSGQD-VFVIGATNRPDLLDPALLR 150
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 483-631 1.07e-19

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 86.71  E-value: 1.07e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 483 VKAVIKEEVLWPVLRSDAFSGL-TALPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEAEKIIHASFL 561
Cdd:cd19526     1 VKKALEETIEWPSKYPKIFASSpLRLRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 562 VARCRQPSVIFVSDIDMLLSSQVNEEHSPVSRMRTEFLMQLDTVltSAEDQIVVICATSKPEEIDESLRR 631
Cdd:cd19526    81 RAQSAKPCILFFDEFDSIAPKRGHDSTGVTDRVVNQLLTQLDGV--EGLDGVYVLAATSRPDLIDPALLR 148
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 472-631 4.47e-19

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 84.98  E-value: 4.47e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 472 VDWNDIAGLDLVKAVIKE--EVLwpvLRSDAFSGLTA-LPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKW 548
Cdd:cd19501     1 VTFKDVAGCEEAKEELKEvvEFL---KNPEKFTKLGAkIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMF 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 549 LGEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQ---VNEEHSPVSRMRTEFLMQLDTVLTSaeDQIVVICATSKPEEI 625
Cdd:cd19501    78 VGVGASRVRDLFEQAKKNAPCIVFIDEIDAVGRKRgagLGGGHDEREQTLNQLLVEMDGFESN--TGVIVIAATNRPDVL 155


                  ....*.
gi 1012443756 626 DESLRR 631
Cdd:cd19501   156 DPALLR 161
ftsH CHL00176
cell division protein; Validated
 472-691 1.51e-17

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 87.03  E-value: 1.51e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 472 VDWNDIAGLDLVKAVIkEEVLWPVLRSDAFSGLTA-LPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLG 550
Cdd:CHL00176  180 ITFRDIAGIEEAKEEF-EEVVSFLKKPERFTAVGAkIPKGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEMFVG 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 551 EAEKIIHASFLVARCRQPSVIFVSDIDML---LSSQVNEEHSPvsrmRTEFLMQLDTVLTSAEDQ--IVVICATSKPEEI 625
Cdd:CHL00176  259 VGAARVRDLFKKAKENSPCIVFIDEIDAVgrqRGAGIGGGNDE----REQTLNQLLTEMDGFKGNkgVIVIAATNRVDIL 334

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1012443756 626 DESLRR--YFMKRLLIPLPDSTARHQIivqlLSQHnycLNDKEFA------LLVQRTEGFSGLDVAHLCQEAVV 691
Cdd:CHL00176  335 DAALLRpgRFDRQITVSLPDREGRLDI----LKVH---ARNKKLSpdvsleLIARRTPGFSGADLANLLNEAAI 401
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
 483-639 3.75e-16

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 76.41  E-value: 3.75e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 483 VKAVIKEEVLWPvLRSDAFSGLTALPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEA--EKIIHASF 560
Cdd:cd19506     2 VRQLLTLYGILP-LGSQAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNglQMMLHLVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 561 LVARCRQPSVIFVSDIDMLLSSQVNEEHSPVSRMRTEFLMQLDTVLTSAEDQIVVICATSKPEEID-ESLRRYFMKRLLI 639
Cdd:cd19506    81 KVARQLQPSVIWIGDAEKTFYKKVPKTEKQLDPKRLKKDLPKILKSLKPEDRVLIVGTTSRPFEADlKSFCKVYNKIILI 160
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 508-641 7.87e-16

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 75.26  E-value: 7.87e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 508 PRSILLFGPRGTGKTLLGRCIASQL---GATFFKIAGSGLVAKWLGEAEK---IIHASFLVARCRQPSVIFVSDIDMLLs 581
Cdd:cd00009    19 PKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAELFghfLVRLLFELAEKAKPGVLFIDEIDSLS- 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1012443756 582 sqvneehspvSRMRTEFLMQLDTVLTSAE--DQIVVICATSKPEEIDESLRRY--FMKRLLIPL 641
Cdd:cd00009    98 ----------RGAQNALLRVLETLNDLRIdrENVRVIGATNRPLLGDLDRALYdrLDIRIVIPL 151
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
470-726 1.78e-11

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 67.37  E-value: 1.78e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 470 PPVDWNDIAGLDLVKAVIKEEVLWpvLRS-DAFSGLTA-LPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAK 547
Cdd:COG0465   137 PKVTFDDVAGVDEAKEELQEIVDF--LKDpEKFTRLGAkIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEM 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 548 WLGeaekiIHAS-----FLVARCRQPSVIFVSDIDmllssqvneehsPVSRMR-------------TefLMQLdtvLT-- 607
Cdd:COG0465   215 FVG-----VGASrvrdlFEQAKKNAPCIIFIDEID------------AVGRQRgaglggghdereqT--LNQL---LVem 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 608 ---SAEDQIVVICATSKPEEIDESLRR--YFMKRLLIPLPDSTARHQIivqlLSQHnycLNDKEFA------LLVQRTEG 676
Cdd:COG0465   273 dgfEGNEGVIVIAATNRPDVLDPALLRpgRFDRQVVVDLPDVKGREAI----LKVH---ARKKPLApdvdleVIARRTPG 345

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1012443756 677 FSGLDVAHLCQEAvvgplhampatdlsAIMP--SQLRPVTYQDFENAFCKIQ 726
Cdd:COG0465   346 FSGADLANLVNEA--------------ALLAarRNKKAVTMEDFEEAIDRVI 383
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 508-643 7.39e-10

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 58.15  E-value: 7.39e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756  508 PRSILLFGPRGTGKTLLGRCIASQLGAT---FFKIAGSGLVAKWLGEAEKIIHASF------------LVARCRQ--PSV 570
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPgggVIYIDGEDILEEVLDQLLLIIVGGKkasgsgelrlrlALALARKlkPDV 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1012443756  571 IFVSDIDMLLSSQVNEEHSPVSRMRTEFLMQLdtvltsaEDQIVVICATSKPEEIDES-LRRYFMKRLLIPLPD 643
Cdd:smart00382  82 LILDEITSLLDAEQEALLLLLEELRLLLLLKS-------EKNLTVILTTNDEKDLGPAlLRRRFDRRIVLLLIL 148
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 476-599 8.85e-10

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 58.15  E-value: 8.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 476 DIAGLDLVKAvikeevlWPVLRSDAFS------GLtALPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWL 549
Cdd:cd19507     1 DVGGLDNLKD-------WLKKRKAAFSkqasayGL-PTPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLV 72

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1012443756 550 GEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQVNE-EHSPVSRMRTEFL 599
Cdd:cd19507    73 GESESRLRQMIQTAEAIAPCVLWIDEIEKGFSNADSKgDSGTSSRVLGTFL 123
ycf46 CHL00195
Ycf46; Provisional
 449-727 2.06e-08

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 57.34  E-value: 2.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 449 QLKNTDTHLIDLVTNE---IITQGP-----PVDW--NDIAGLDLVKavikeevLWPVLRSDAFS------GLTAlPRSIL 512
Cdd:CHL00195  192 TYKTIDENSIPLILEEkkqIISQTEilefySVNEkiSDIGGLDNLK-------DWLKKRSTSFSkqasnyGLPT-PRGLL 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 513 LFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEAEKIIHASFLVARCRQPSVIFVSDIDMLLS-SQVNEEHSPV 591
Cdd:CHL00195  264 LVGIQGTGKSLTAKAIANDWQLPLLRLDVGKLFGGIVGESESRMRQMIRIAEALSPCILWIDEIDKAFSnSESKGDSGTT 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 592 SRMRTEFLMQLdtvltSAEDQIVVICAT-----SKPEEIdesLRR-YFMKRLLIPLPDSTARHQIIVQLLSQ------HN 659
Cdd:CHL00195  344 NRVLATFITWL-----SEKKSPVFVVATannidLLPLEI---LRKgRFDEIFFLDLPSLEEREKIFKIHLQKfrpkswKK 415

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1012443756 660 YclndkEFALLVQRTEGFSGLDVahlcQEAVVGPLHampatdlsaIMPSQLRPVTYQDFENAFCKIQP 727
Cdd:CHL00195  416 Y-----DIKKLSKLSNKFSGAEI----EQSIIEAMY---------IAFYEKREFTTDDILLALKQFIP 465
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 509-631 1.46e-07

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 52.11  E-value: 1.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 509 RSILLFGPRGTGKTLLGRCIASQLGATFFKIA-GSGLVAKWLGEAEKIIHASFLVARCRQPS--------VIFVSDIDML 579
Cdd:cd19504    36 KGILLYGPPGTGKTLMARQIGKMLNAREPKIVnGPEILNKYVGESEANIRKLFADAEEEQRRlgansglhIIIFDEIDAI 115

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1012443756 580 LSSQ--VNEEHSPVSRMRTEFLMQLDTVltSAEDQIVVICATSKPEEIDESLRR 631
Cdd:cd19504   116 CKQRgsMAGSTGVHDTVVNQLLSKIDGV--EQLNNILVIGMTNRKDLIDEALLR 167
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 506-626 1.60e-06

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 48.29  E-value: 1.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 506 ALPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGsGLVAKWLGEAEKIIHASFLVA-RCRQPSVIFVSDIDMLLSSQV 584
Cdd:cd19512    20 GLYRNILFYGPPGTGKTLFAKKLALHSGMDYAIMTG-GDVAPMGREGVTAIHKVFDWAnTSRRGLLLFVDEADAFLRKRS 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1012443756 585 NEEHSPVSRmrteflMQLDTVLTSAEDQ---IVVICATSKPEEID 626
Cdd:cd19512    99 TEKISEDLR------AALNAFLYRTGEQsnkFMLVLASNQPEQFD 137
Vps4_C pfam09336
Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase ...
 712-745 1.17e-05

Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase proteins involved in vacuolar sorting. It forms an alpha helix structure and is required for oligomerization.


Pssm-ID: 462762 [Multi-domain]  Cd Length: 61  Bit Score: 43.25  E-value: 1.17e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1012443756 712 PVTYQDFENAFCKIQPSISQKELDMYVEWNKMFG 745
Cdd:pfam09336  28 PVTMKDFLKALKSSRPTVSKEDLEKYEEFTKEFG 61
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 510-633 2.56e-05

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 44.59  E-value: 2.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 510 SILLFGPRGTGKTLLGRCIASQL-GATFFKIAGSG------LVAKW-LGEAEKIIHASFLVARCRQPSVIFVSDIDMLLS 581
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAALsNRPVFYVQLTRdtteedLFGRRnIDPGGASWVDGPLVRAAREGEIAVLDEINRANP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1012443756 582 SQVNEEHSPVSRmRTEFLMQLDTVLTSAEDQIVVIcATSKP-----EEIDESLRRYF 633
Cdd:pfam07728  81 DVLNSLLSLLDE-RRLLLPDGGELVKAAPDGFRLI-ATMNPldrglNELSPALRSRF 135
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 509-631 1.37e-04

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 42.72  E-value: 1.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 509 RSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAkwlgEAEKIIHasfLVARCRQPSVIFVSDIDMLLSSQvneEH 588
Cdd:cd19510    24 RGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEVVL----TDDRLNH---LLNTAPKQSIILLEDIDAAFESR---EH 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1012443756 589 SPVSRMRTEF---------LMQLDTVlTSAEDQIVVIcATSKPEEIDESLRR 631
Cdd:cd19510    94 NKKNPSAYGGlsrvtfsglLNALDGV-ASSEERIVFM-TTNHIERLDPALIR 143
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 487-629 1.63e-04

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 43.59  E-value: 1.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 487 IKEEVLWPVLRSDAFS------GLTALPRSILLFGPRGTGKTLLGRCIASQLG---------ATFFKIAGSGLVAKWLGE 551
Cdd:cd19508    25 LKSRLLDYVTTTLLFSdknvntNLITWNRLVLLHGPPGTGKTSLCKALAQKLSirlssryryGQLIEINSHSLFSKWFSE 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 552 AEKIIHASF-----LVARCRQPSVIFVSDIDMLLSSQVN----EEHSPVSRMRTEFLMQLDTVLTSaeDQIVVICATSKP 622
Cdd:cd19508   105 SGKLVTKMFqkiqeLIDDKDALVFVLIDEVESLAAARSAsssgTEPSDAIRVVNAVLTQIDRIKRY--HNNVILLTSNLL 182


                  ....*..
gi 1012443756 623 EEIDESL 629
Cdd:cd19508   183 EKIDVAF 189
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
 510-582 3.81e-04

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 42.16  E-value: 3.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 510 SILLF-GPRGTGKTLLGRCIASQLGATFFKIAGSGLVakwlGEAE--------------KIIHAsFLVARCRQPsVIFVS 574
Cdd:cd19500    38 PILCLvGPPGVGKTSLGKSIARALGRKFVRISLGGVR----DEAEirghrrtyvgampgRIIQA-LKKAGTNNP-VFLLD 111


                  ....*...
gi 1012443756 575 DIDMLLSS 582
Cdd:cd19500   112 EIDKIGSS 119
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 510-537 4.26e-04

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 41.39  E-value: 4.26e-04
                          10        20
                  ....*....|....*....|....*...
gi 1012443756 510 SILLFGPRGTGKTLLGRCIASQLGATFF 537
Cdd:cd00464     1 NIVLIGMMGAGKTTVGRLLAKALGLPFV 28
RecA-like_HslU cd19498
ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease ...
 507-593 7.59e-04

ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease HslVU. In HslVU, HslU ATPase serves to unfold and translocate protein substrate, and the HslV protease degrades the unfolded proteins. This RecA-like_HslU subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410906 [Multi-domain]  Cd Length: 183  Bit Score: 41.21  E-value: 7.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443756 507 LPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGS-----GLVAKwlgEAEKIIhasflvaRCRQPSVIFVSDIDMLLS 581
Cdd:cd19498    45 TPKNILMIGPTGVGKTEIARRLAKLAGAPFIKVEATkftevGYVGR---DVESII-------RDLVEGIVFIDEIDKIAK 114

                          90
                  ....*....|...
gi 1012443756 582 SqvNEEHSP-VSR 593
Cdd:cd19498   115 R--GGSSGPdVSR 125
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 664-695 1.30e-03

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 37.13  E-value: 1.30e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1012443756 664 DKEFALLVQRTEGFSGLDVAHLCQEAVVGPLH 695
Cdd:pfam17862   1 DVDLEELAERTEGFSGADLEALCREAALAALR 32
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 508-539 1.80e-03

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 41.22  E-value: 1.80e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1012443756 508 PRSILLFGPRGTGKTLLGRCIASQLGATFFKI 539
Cdd:PRK13342   36 LSSMILWGPPGTGKTTLARIIAGATDAPFEAL 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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