MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane and are capable of cleaving growth factors, extracellular matrix proteins, and biologically active peptides. TRAF molecules serve as adapter proteins that link cell surface receptors of the Tumor Necrosis Factor and 1nterleukin-1/Toll-like families to downstream kinase cascades, which results in the activation of transcription factors and the regulation of cell survival, proliferation and stress responses in the immune and inflammatory systems. Other members include the ubiquitin ligases, TRIM37 and SPOP, and the ubiquitin-specific proteases, HAUSP and Ubp21p. A large number of uncharacterized members mostly from lineage-specific expansions in C. elegans and rice contain MATH and BTB domains, similar to SPOP. The MATH domain has been shown to bind peptide/protein substrates in TRAFs and HAUSP. It is possible that the MATH domain in other members of this superfamily also interacts with various protein substrates. The TRAF domain may also be involved in the trimerization of TRAFs. Based on homology, it is postulated that the MATH domain in meprins may be involved in its tetramer assembly and that the MATH domain, in general, may take part in diverse modular arrangements defined by adjacent multimerization domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305   1 MRIKRDNGFMSFGLYCPMTGKTT-NWSIVADIRVELMPLTGMWKSVECECKIAKSpsliSEVLRSTIMPWGRMMTNYVVD 79
Cdd:pfam00917  27 LQIYRKGGFLGLYLHCDKEEELErGWSIETEFTLKLVSSNGKSVTKTDTHVFEKP----KGWGWGKFISWDDLEKDYLVD 102

                          90
                  ....*....|.
gi 1017368305  80 DALMIEVFVTI 90
Cdd:pfam00917 103 DSITVEAHVKI 113

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305  114 DVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLYGDSA-INDLTVEGILHIADMY 192
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLdLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 1017368305  193 DTPMVVRKCEEFLIKGT 209
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97

MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This domain is hugely expanded in the nematode C. elegans.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305   1 MRIKRDNGFMSFGLYCPMTGKTT-NWSIVADIRVELMPLTGMWKSVECECKIAKSpsliSEVLRSTIMPWGRMMTNYVVD 79
Cdd:pfam00917  27 LQIYRKGGFLGLYLHCDKEEELErGWSIETEFTLKLVSSNGKSVTKTDTHVFEKP----KGWGWGKFISWDDLEKDYLVD 102

                          90
                  ....*....|.
gi 1017368305  80 DALMIEVFVTI 90
Cdd:pfam00917 103 DSITVEAHVKI 113

MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane and are capable of cleaving growth factors, extracellular matrix proteins, and biologically active peptides. TRAF molecules serve as adapter proteins that link cell surface receptors of the Tumor Necrosis Factor and 1nterleukin-1/Toll-like families to downstream kinase cascades, which results in the activation of transcription factors and the regulation of cell survival, proliferation and stress responses in the immune and inflammatory systems. Other members include the ubiquitin ligases, TRIM37 and SPOP, and the ubiquitin-specific proteases, HAUSP and Ubp21p. A large number of uncharacterized members mostly from lineage-specific expansions in C. elegans and rice contain MATH and BTB domains, similar to SPOP. The MATH domain has been shown to bind peptide/protein substrates in TRAFs and HAUSP. It is possible that the MATH domain in other members of this superfamily also interacts with various protein substrates. The TRAF domain may also be involved in the trimerization of TRAFs. Based on homology, it is postulated that the MATH domain in meprins may be involved in its tetramer assembly and that the MATH domain, in general, may take part in diverse modular arrangements defined by adjacent multimerization domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305   6 DNGFMSFGLYCpMTGKTT--NWSIVADIRVELMPLTGmWKSVECECKIAKSPSLISEVLRSTIMPWGRMMTNY-VVDDAL 82
Cdd:cd00121    42 SGDYLSLYLEL-DKGESDleKWSVRAEFTLKLVNQNG-GKSLSKSFTHVFFSEKGSGWGFPKFISWDDLEDSYyLVDDSL 119

                  ....*..
gi 1017368305  83 MIEVFVT 89
Cdd:cd00121   120 TIEVEVK 126

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305  114 DVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLYGDSA-INDLTVEGILHIADMY 192
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLdLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 1017368305  193 DTPMVVRKCEEFLIKGT 209
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305 112 FSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLY-GDSAINDLTVEGILHIAD 190
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYtGELELSEENVEELLAAAD 80

                  ..
gi 1017368305 191 MY 192
Cdd:cd18186    81 KL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305 110 EEFSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLY-GDSAINDLTVEGILHI 188
Cdd:cd18257    16 HELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYtGTVFISQATVESLLPA 95

                          90
                  ....*....|....*..
gi 1017368305 189 ADMYDTPMVVRKCEEFL 205
Cdd:cd18257    96 ANLLQIKLVLKECCDFL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305 110 EEFSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLY-GDSAINDL---TVEGI 185
Cdd:cd18287    20 EEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYtGRLTLTDLkedVLLDV 99

                  ....*...
gi 1017368305 186 LHIADMYD 193
Cdd:cd18287   100 LGLAHQYG 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305 110 EEFSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLY-GDSAINDLTVEGILHI 188
Cdd:cd18237    19 KTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYtARISVNSNNVQSLLDA 98

                          90
                  ....*....|....*..
gi 1017368305 189 ADMYDTPMVVRKCEEFL 205
Cdd:cd18237    99 ANQYQIEPVKKMCVDFL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305 112 FSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLY-GDSAINDLTVEGILHIAD 190
Cdd:cd18340    27 FVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYtSEIEITEQNVQDIFAAAN 106

                          90
                  ....*....|....*..
gi 1017368305 191 MYDTPMVVRKCEEFLIK 207
Cdd:cd18340   107 MFQIPSIFTVCVSFLQK 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305 112 FSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLY-GDSAINDLTVEGILHIAD 190
Cdd:cd18269    27 FVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYtSEIDLNDQNVQDIFALAS 106

                          90
                  ....*....|....*..
gi 1017368305 191 MYDTPMVVRKCEEFLIK 207
Cdd:cd18269   107 RFQIPSIFTVCVSYLQK 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305 113 SDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLY-GDSAINDLTVEGILHIADM 191
Cdd:cd18234     2 CDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYtGRLELKEDNVESLLATACL 81

                          90
                  ....*....|....*.
gi 1017368305 192 YDTPMVVRKCEEFLIK 207
Cdd:cd18234    82 LQLSEVVEACCGFLMK 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305 114 DVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLY-GDSAINDLTVEGILHIADMY 192
Cdd:cd18247    21 DVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYsGRIAIDTSNVQSLLVGASFL 100

                          90
                  ....*....|....*
gi 1017368305 193 DTPMVVRKCEEFLIK 207
Cdd:cd18247   101 QLQSVKDACCEFLKE 115

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305 110 EEFSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLYGDSA--INDLTVEGILH 187
Cdd:cd18300     7 GLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQApiLEDGDCVGLIV 86

                          90       100
                  ....*....|....*....|.
gi 1017368305 188 IADMYDTPMVVRKCEEFLIKG 208
Cdd:cd18300    87 LANRLCLPRLVALCEQYIVKE 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305 110 EEFSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLYGDSAINDLTVEG----- 184
Cdd:cd18280    12 EEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYKDELPDDVEPAGsdsss 91

                          90       100
                  ....*....|....*....|....*.
gi 1017368305 185 --------ILHIADMYDTPMVVRKCE 202
Cdd:cd18280    92 ldttmaqhLLAAADRYALERLRLLCE 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305 101 NLRSFDESmEEFSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLY-GDSAIND 179
Cdd:cd18238     5 VLHQFYEN-GELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYtGKLTLTV 83

                          90       100
                  ....*....|....*....|....*.
gi 1017368305 180 LTVEGILHIADMYDTPMVVRKCEEFL 205
Cdd:cd18238    84 DNVQSLLYAASLLQVEEVAKACCEFM 109

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305 101 NLRSFDESMEEFSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEE-----GKSSEVTLTSIDPNDFQFFLEVLYGDS 175
Cdd:cd18296     6 ELPFPPEQELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAEseennGSIPVVTLHDVSPEVFAIVLYYIYTDD 85

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1017368305 176 A-INDLTVEGILHIADMYDTPMVVRKCEEFLIK 207
Cdd:cd18296    86 TdLPPENAYDVLYVADMYLLPGLKRLCGTVLAQ 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305 111 EFSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLY-GDSAINDLTVEGILHIA 189
Cdd:cd18341    26 KFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLYsAEIDLNDGNVQDIFALA 105

                          90
                  ....*....|....*...
gi 1017368305 190 DMYDTPMVVRKCEEFLIK 207
Cdd:cd18341   106 SRFQIPSVFTVCVTYLQK 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305 102 LRSFDESMEE--FSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDF-QFFLEVLYGDSAIN 178
Cdd:cd18268    11 LRQLNSLRQEriLTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLdQIVDYVYTGEILIT 90

                          90       100
                  ....*....|....*....|....*..
gi 1017368305 179 DLTVEGILHIADMYDTPMVVRKCEEFL 205
Cdd:cd18268    91 RDNVLPLMEAASMLQYPKLFEACSLYL 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305 111 EFSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLYGDS-AINDLTVEGILHIA 189
Cdd:cd18249    22 ELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYTSQiTVEEGNVQTLLPAA 101

                          90
                  ....*....|....*.
gi 1017368305 190 DMYDTPMVVRKCEEFL 205
Cdd:cd18249   102 CLLQLAEIQEVCCEFL 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305 112 FSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTL-TSIDPNDFQFFLEVLYGDS-AINDLTVEGILHIA 189
Cdd:cd18254    22 FTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFhDSLHPEVLELLLDFAYSSRiIINEENAESLLEAG 101

                          90
                  ....*....|....*...
gi 1017368305 190 DMYDTPMVVRKCEEFLIK 207
Cdd:cd18254   102 DMLQFHDVRDAAAEFLEK 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305 111 EFSDVVLLVGEKKFYVLRKYLAaQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLYG-----DSAINDLTVEGI 185
Cdd:cd18305    14 ENSDITICALGREWKLHKIYLC-QSGYFASMFSGSWKESKETVINLEIPDDNITVEALNVVFGslyrdEIEIKPSRVVSI 92

                          90       100
                  ....*....|....*....|.
gi 1017368305 186 LHIADMYDTPMVVRKCEEFLI 206
Cdd:cd18305    93 LAAATLLQLDGLIQQCSEVMK 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305 112 FSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLYGDSAIN-DLTVEGILHIAD 190
Cdd:cd18343    21 FTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNlDKMADNLLAAAD 100

                          90
                  ....*....|....*
gi 1017368305 191 MYDTPMVVRKCEEFL 205
Cdd:cd18343   101 KYALERLKVMCEEAL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305 113 SDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLYGDSA-INDLTVEGILHIADM 191
Cdd:cd18236    25 TDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKVlITKQNVQRVLEAASL 104

                          90
                  ....*....|....
gi 1017368305 192 YDTPMVVRKCEEFL 205
Cdd:cd18236   105 FQFLRMVDACASFL 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305 110 EEFSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLY-GDSAINDLTVEGILHI 188
Cdd:cd18297    10 PEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYtGGVESLDVAQDDALEL 89

                          90       100
                  ....*....|....*....|
gi 1017368305 189 ---ADMYDTPMVVRKCEEFL 205
Cdd:cd18297    90 lraASFFQLDGLKRHCEILL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305 106 DESMEE--FSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLY-GDSAINDLTV 182
Cdd:cd18272    24 DLCLEDglFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYhGTVKLRVEEL 103

                          90       100
                  ....*....|....*....|....*
gi 1017368305 183 EGILHIADMYDTPMVVRKCEEFLIK 207
Cdd:cd18272   104 QETYEVADMYQLTALFEECSRFLAR 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305 102 LRSFDESmEEFSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLY-GDSAINDL 180
Cdd:cd18271    15 LQNFREQ-NAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYtGKAEITDD 93

                          90       100
                  ....*....|....*....|....*..
gi 1017368305 181 TVEGILHIADMYDTPMVVRKCEEFLIK 207
Cdd:cd18271    94 NVEMFFQMSSFLQVSLLSKACSDFLIK 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305 114 DVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLYGDS-AINDLTVEGILHIADMY 192
Cdd:cd18328    27 DVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPEALSAILEFAYTSTlTITTSNVKHILNAAQML 106

                          90
                  ....*....|...
gi 1017368305 193 DTPMVVRKCEEFL 205
Cdd:cd18328   107 EIQCIINVCLEIM 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368305 114 DVVLLVGEKKFYVLRKYLAAQSKYFKALllgsFEEGKSSEVTL--TSIDPNDFQFFLEVLY-GDSAINDLTVEGILHIAD 190
Cdd:cd18217    20 DCTIVIGQFQFKAHRNVLAAFSEYFGAQ----YKDTEDNIVFLdqSQVSADGFQKLLEFIYtGNLNLDSWNVAEIHQAAS 95