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Conserved domains on  [gi|1018191517|ref|NP_001309757|]
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zinc finger protein 461 isoform 6 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 12142358)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
224-427 5.80e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 5.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191517 224 QRSQLTQHQRLHTGE-----KPYECKQCGKAFIRGFQLTEHLR--LHTGE--KPYECKE--CGKTFRHRSHLTIHQRIHT 292
Cdd:COG5048   268 ASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191517 293 GEKPYECRECgkafsyHSSFSHHQKIHSgkkpyechecgkafcDGLQLTLHQRIHTGEKPYEC--KECGKTFRQCSHLKR 370
Cdd:COG5048   348 SISPAKEKLL------NSSSKFSPLLNN---------------EPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSL 406

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1018191517 371 HQRIHTGEKPHECM--ICGKAFRLHSHLIQHQRIHTGEKPYECkECGKAFSYHSSFSHH 427
Cdd:COG5048   407 HIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
199-224 2.68e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.68e-03
                          10        20
                  ....*....|....*....|....*.
gi 1018191517 199 ELTLHQRIHTGEKPYECKECGKAFRQ 224
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
224-427 5.80e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 5.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191517 224 QRSQLTQHQRLHTGE-----KPYECKQCGKAFIRGFQLTEHLR--LHTGE--KPYECKE--CGKTFRHRSHLTIHQRIHT 292
Cdd:COG5048   268 ASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191517 293 GEKPYECRECgkafsyHSSFSHHQKIHSgkkpyechecgkafcDGLQLTLHQRIHTGEKPYEC--KECGKTFRQCSHLKR 370
Cdd:COG5048   348 SISPAKEKLL------NSSSKFSPLLNN---------------EPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSL 406

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1018191517 371 HQRIHTGEKPHECM--ICGKAFRLHSHLIQHQRIHTGEKPYECkECGKAFSYHSSFSHH 427
Cdd:COG5048   407 HIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
367-390 4.77e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.77e-04
                          10        20
                  ....*....|....*....|....
gi 1018191517 367 HLKRHQRIHTGEKPHECMICGKAF 390
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
199-224 2.68e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.68e-03
                          10        20
                  ....*....|....*....|....*.
gi 1018191517 199 ELTLHQRIHTGEKPYECKECGKAFRQ 224
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
224-427 5.80e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 5.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191517 224 QRSQLTQHQRLHTGE-----KPYECKQCGKAFIRGFQLTEHLR--LHTGE--KPYECKE--CGKTFRHRSHLTIHQRIHT 292
Cdd:COG5048   268 ASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191517 293 GEKPYECRECgkafsyHSSFSHHQKIHSgkkpyechecgkafcDGLQLTLHQRIHTGEKPYEC--KECGKTFRQCSHLKR 370
Cdd:COG5048   348 SISPAKEKLL------NSSSKFSPLLNN---------------EPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSL 406

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1018191517 371 HQRIHTGEKPHECM--ICGKAFRLHSHLIQHQRIHTGEKPYECkECGKAFSYHSSFSHH 427
Cdd:COG5048   407 HIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
379-475 1.95e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 1.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191517 379 KPHECMICGKAFRLHSHLIQHQRIHTGEKPYEC--KECGKAFSYHSSFSHHQRIHSGKKPYQCGKAFNHRLQLNLHQTLH 456
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90
                  ....*....|....*....
gi 1018191517 457 TGEKPVRFPLLPPHPSLAS 475
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPP 130
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
141-473 2.28e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 2.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191517 141 NTPCLFKQQTIQNGDKCNECKECWKAFVHCSQLK-HLRIHNGEKRYECNECGKAFNYG--SELTLHQRIHTGEKPYE--- 214
Cdd:COG5048    17 SSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTrHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLnsk 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191517 215 --------------------------CKECGKAFRQRSQLTQHQRLHTGEKPYECKQCGKAFIRGFQ------------- 255
Cdd:COG5048    97 slplsnskasssslsssssnsndnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnslhpplpansl 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191517 256 ---------LTEHLRLHTGEKPYECKECGKTFRHRSHLTIHQRIHTGEKPYECRECGKAFSYH------SSFSHHQKIHS 320
Cdd:COG5048   177 skdpssnlsLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSS 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191517 321 GKKPYECHECGKAFCDGLQLTLHQRIHTG-EKPYECKECGKTFRQCSHLKRHQR--IHTGE--KPHEC--MICGKAFRLH 393
Cdd:COG5048   257 ASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRN 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191517 394 SHLIQHQRIHTGEKPYECK--ECGKAFS------YHSSFSHHQRIHSGKKPYQ----CGKAFNHRLQLNLHQTLHTGEKP 461
Cdd:COG5048   337 DALKRHILLHTSISPAKEKllNSSSKFSpllnnePPQSLQQYKDLKNDKKSETlsnsCIRNFKRDSNLSLHIITHLSFRP 416

                         410
                  ....*....|..
gi 1018191517 462 VRFPLLPPHPSL 473
Cdd:COG5048   417 YNCKNPPCSKSF 428
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
183-332 4.09e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 4.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191517 183 KRYECNECGKAFNYGSELTLHQR--IHTGE--KPYECKE--CGKAFRQRSQLTQHQRLHTGEKPYECKQC-------GKA 249
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191517 250 FIRGFQLTEHLRLHTGEKPYEC--KECGKTFRHRSHLTIHQRIHTGEKPYECR--ECGKAFSYHSSFSHHQKIHSGKKPY 325
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447


                  ....*..
gi 1018191517 326 ECHECGK 332
Cdd:COG5048   448 LCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
295-439 7.66e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 7.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191517 295 KPYECRECGKAFSYHSSFSHHQ--KIHSGK--KPYECHE--CGKAFCDGLQLTLHQRIHTGEKPYECK--ECGKTFRQCS 366
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191517 367 HLKRHQRIH-----TGEKPHEC-MICGKAFRLHSHLIQHQRI-HTGEKPYECK--ECGKAFSYHSSFSHHQRIHSGKKPY 437
Cdd:COG5048   368 NNEPPQSLQqykdlKNDKKSETlSNSCIRNFKRDSNLSLHIItHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447


                  ..
gi 1018191517 438 QC 439
Cdd:COG5048   448 LC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
367-390 4.77e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.77e-04
                          10        20
                  ....*....|....*....|....
gi 1018191517 367 HLKRHQRIHTGEKPHECMICGKAF 390
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
395-420 6.79e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.79e-04
                          10        20
                  ....*....|....*....|....*.
gi 1018191517 395 HLIQHQRIHTGEKPYECKECGKAFSY 420
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
140-315 1.60e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 1.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191517 140 VNTPCLFKQQTIQNGDKCNECKECwkafvhCSQLKHLR------IHNGE--KRYECNE--CGKAFNYGSELTLHQRIHTG 209
Cdd:COG5048   275 PNESDSSSEKGFSLPIKSKQCNIS------FSRSSPLTrhlrsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191517 210 EKPYECK--ECGKAFRQRS-----QLTQHQRLHTGEKPYEC--KQCGKAFIRGFQLTEHLRLHTGEKPYECK--ECGKTF 278
Cdd:COG5048   349 ISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSF 428

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1018191517 279 RHRSHLTIHQRIHTGEKPYECRECGKaFSYHSSFSHH 315
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
283-308 2.51e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.51e-03
                          10        20
                  ....*....|....*....|....*.
gi 1018191517 283 HLTIHQRIHTGEKPYECRECGKAFSY 308
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
199-224 2.68e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.68e-03
                          10        20
                  ....*....|....*....|....*.
gi 1018191517 199 ELTLHQRIHTGEKPYECKECGKAFRQ 224
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 349-427 2.71e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 2.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191517 349 GEKPYECK--ECGKTFRQCSHLKRHQRI-HTGEKPHEcmicgkafrlHSHLIQHQRIHTGEKPYECKECGKAF------S 419
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHE----------NPSPEKMNIFSAKDKPYRCEVCDKRYknlnglK 415


                  ....*...
gi 1018191517 420 YHSSFSHH 427
Cdd:COG5189   416 YHRKHSHD 423
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 353-375 3.42e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.42e-03
                          10        20
                  ....*....|....*....|...
gi 1018191517 353 YECKECGKTFRQCSHLKRHQRIH 375
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
228-252 4.47e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.47e-03
                          10        20
                  ....*....|....*....|....*
gi 1018191517 228 LTQHQRLHTGEKPYECKQCGKAFIR 252
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 269-291 4.87e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.87e-03
                          10        20
                  ....*....|....*....|...
gi 1018191517 269 YECKECGKTFRHRSHLTIHQRIH 291
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
340-364 5.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.08e-03
                          10        20
                  ....*....|....*....|....*
gi 1018191517 340 LTLHQRIHTGEKPYECKECGKTFRQ 364
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-280 5.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.66e-03
                          10        20
                  ....*....|....*....|....*
gi 1018191517 256 LTEHLRLHTGEKPYECKECGKTFRH 280
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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