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Conserved domains on  [gi|1020738801|ref|NP_001310327|]
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dematin isoform 7 [Homo sapiens]

Protein Classification

actin-binding LIM protein; villin family protein( domain architecture ID 11241350)

actin-binding LIM protein (abLIM) may act as a scaffold protein for signaling modules of the actin cytoskeleton| villin family protein similar to Oryza sativa villin-4, a Ca(2+)-regulated actin-binding protein involved in actin filament bundling, severing and capping

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AbLIM_anchor pfam16182
Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between ...
 7-293 4.74e-79

Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between the LIM actin-binding and the vilin-head domain of actin-binding LIM proteins. It is likely that this domain is involved in anchoring abLIMs to circumferential actin bundles in specific cell types.


:

Pssm-ID: 465046 [Multi-domain]  Cd Length: 319  Bit Score: 244.31  E-value: 4.74e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738801   7 AKMDNQVLGYKDLAAIPKDKAILDIERPDLMIYEPHFTYSLLEHVE-----------------LPRSREV-WADSRSPGI 68
Cdd:pfam16182  26 AKLDNEILDYKDLAALPKVKAIYDIERPDLISYEPYVSYSSDDRLErqsygeslstlspssedSYDSRELrQRRSSSPGS 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738801  69 ISQASAPRTTGTPRTS--LPHFHHPET--------------------------------SRPDSNIYKKPPIYKQRESVG 114
Cdd:pfam16182 106 IGSPTYSRHGYTPTLSrsPQHFHRPGSesgrsspslsqpsdrkspptyvqapkhfhvpdTGVKDNIYRKPPIYKQHGTSA 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738801 115 GSPQTkhliEDLIIESSKFPAAqppdpnqpakietdywpcppslAVVETEWRkrkasrrgaeeeeeeedddsgeemkaLR 194
Cdd:pfam16182 186 SASQS----SEDIIHSSRFPAS----------------------GGEEEGWN--------------------------RR 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738801 195 ERQREELSKVTSNLGKMILKEEME-KSLPIRRKTRSLPDRTPFHTSL-HQGTSKSSSLPAYGRTTLSRLQSTEFSPSGSE 272
Cdd:pfam16182 214 LLQEEELSKIQSGLGKLILKEEMEaRSGSERRDPWSSPRSSPSGSSGsDSPYSKSASLPGYGRNGLHRPQSADFFQYGSD 293

                         330       340
                  ....*....|....*....|....*.
gi 1020738801 273 TGSPG-----LQIYPYEMLVVTNKGR 293
Cdd:pfam16182 294 GDVSWggmreYKIYPYEMLAVTNRGR 319
VHP smart00153
Villin headpiece domain;
308-343 2.99e-14

Villin headpiece domain;


:

Pssm-ID: 128458  Cd Length: 36  Bit Score: 65.80  E-value: 2.99e-14
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1020738801  308 HLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF 343
Cdd:smart00153   1 YLSDEDFEEVFGMTREEFYKLPLWKQNQLKKKKGLF 36
 
Name Accession Description Interval E-value
AbLIM_anchor pfam16182
Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between ...
 7-293 4.74e-79

Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between the LIM actin-binding and the vilin-head domain of actin-binding LIM proteins. It is likely that this domain is involved in anchoring abLIMs to circumferential actin bundles in specific cell types.


Pssm-ID: 465046 [Multi-domain]  Cd Length: 319  Bit Score: 244.31  E-value: 4.74e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738801   7 AKMDNQVLGYKDLAAIPKDKAILDIERPDLMIYEPHFTYSLLEHVE-----------------LPRSREV-WADSRSPGI 68
Cdd:pfam16182  26 AKLDNEILDYKDLAALPKVKAIYDIERPDLISYEPYVSYSSDDRLErqsygeslstlspssedSYDSRELrQRRSSSPGS 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738801  69 ISQASAPRTTGTPRTS--LPHFHHPET--------------------------------SRPDSNIYKKPPIYKQRESVG 114
Cdd:pfam16182 106 IGSPTYSRHGYTPTLSrsPQHFHRPGSesgrsspslsqpsdrkspptyvqapkhfhvpdTGVKDNIYRKPPIYKQHGTSA 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738801 115 GSPQTkhliEDLIIESSKFPAAqppdpnqpakietdywpcppslAVVETEWRkrkasrrgaeeeeeeedddsgeemkaLR 194
Cdd:pfam16182 186 SASQS----SEDIIHSSRFPAS----------------------GGEEEGWN--------------------------RR 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738801 195 ERQREELSKVTSNLGKMILKEEME-KSLPIRRKTRSLPDRTPFHTSL-HQGTSKSSSLPAYGRTTLSRLQSTEFSPSGSE 272
Cdd:pfam16182 214 LLQEEELSKIQSGLGKLILKEEMEaRSGSERRDPWSSPRSSPSGSSGsDSPYSKSASLPGYGRNGLHRPQSADFFQYGSD 293

                         330       340
                  ....*....|....*....|....*.
gi 1020738801 273 TGSPG-----LQIYPYEMLVVTNKGR 293
Cdd:pfam16182 294 GDVSWggmreYKIYPYEMLAVTNRGR 319
VHP smart00153
Villin headpiece domain;
308-343 2.99e-14

Villin headpiece domain;


Pssm-ID: 128458  Cd Length: 36  Bit Score: 65.80  E-value: 2.99e-14
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1020738801  308 HLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF 343
Cdd:smart00153   1 YLSDEDFEEVFGMTREEFYKLPLWKQNQLKKKKGLF 36
VHP pfam02209
Villin headpiece domain;
308-343 1.44e-12

Villin headpiece domain;


Pssm-ID: 460493  Cd Length: 36  Bit Score: 61.24  E-value: 1.44e-12
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1020738801 308 HLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF 343
Cdd:pfam02209   1 YLSDEDFEEVFGMSREEFYKLPKWKQNNLKKKAGLF 36
 
Name Accession Description Interval E-value
AbLIM_anchor pfam16182
Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between ...
 7-293 4.74e-79

Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between the LIM actin-binding and the vilin-head domain of actin-binding LIM proteins. It is likely that this domain is involved in anchoring abLIMs to circumferential actin bundles in specific cell types.


Pssm-ID: 465046 [Multi-domain]  Cd Length: 319  Bit Score: 244.31  E-value: 4.74e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738801   7 AKMDNQVLGYKDLAAIPKDKAILDIERPDLMIYEPHFTYSLLEHVE-----------------LPRSREV-WADSRSPGI 68
Cdd:pfam16182  26 AKLDNEILDYKDLAALPKVKAIYDIERPDLISYEPYVSYSSDDRLErqsygeslstlspssedSYDSRELrQRRSSSPGS 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738801  69 ISQASAPRTTGTPRTS--LPHFHHPET--------------------------------SRPDSNIYKKPPIYKQRESVG 114
Cdd:pfam16182 106 IGSPTYSRHGYTPTLSrsPQHFHRPGSesgrsspslsqpsdrkspptyvqapkhfhvpdTGVKDNIYRKPPIYKQHGTSA 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738801 115 GSPQTkhliEDLIIESSKFPAAqppdpnqpakietdywpcppslAVVETEWRkrkasrrgaeeeeeeedddsgeemkaLR 194
Cdd:pfam16182 186 SASQS----SEDIIHSSRFPAS----------------------GGEEEGWN--------------------------RR 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020738801 195 ERQREELSKVTSNLGKMILKEEME-KSLPIRRKTRSLPDRTPFHTSL-HQGTSKSSSLPAYGRTTLSRLQSTEFSPSGSE 272
Cdd:pfam16182 214 LLQEEELSKIQSGLGKLILKEEMEaRSGSERRDPWSSPRSSPSGSSGsDSPYSKSASLPGYGRNGLHRPQSADFFQYGSD 293

                         330       340
                  ....*....|....*....|....*.
gi 1020738801 273 TGSPG-----LQIYPYEMLVVTNKGR 293
Cdd:pfam16182 294 GDVSWggmreYKIYPYEMLAVTNRGR 319
VHP smart00153
Villin headpiece domain;
308-343 2.99e-14

Villin headpiece domain;


Pssm-ID: 128458  Cd Length: 36  Bit Score: 65.80  E-value: 2.99e-14
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1020738801  308 HLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF 343
Cdd:smart00153   1 YLSDEDFEEVFGMTREEFYKLPLWKQNQLKKKKGLF 36
VHP pfam02209
Villin headpiece domain;
308-343 1.44e-12

Villin headpiece domain;


Pssm-ID: 460493  Cd Length: 36  Bit Score: 61.24  E-value: 1.44e-12
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1020738801 308 HLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF 343
Cdd:pfam02209   1 YLSDEDFEEVFGMSREEFYKLPKWKQNNLKKKAGLF 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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