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Conserved domains on  [gi|1021312380|ref|NP_001310513|]
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ATP-dependent RNA helicase SUPV3L1, mitochondrial isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEXQc_Suv3 cd17913
DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA ...
 69-214 3.16e-99

DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA unwinding enzyme belonging to the class of DexH-box helicases. It localizes predominantly in the mitochondria, where it forms an RNA-degrading complex called mitochondrial degradosome (mtEXO) with exonuclease PNP (polynucleotide phosphorylase), that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Suv3 plays a role in the RNA surveillance system in mitochondria; it regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. It also confers salinity and drought stress tolerance by maintaining both photosynthesis and antioxidant machinery, probably via an increase in plant hormone levels such as gibberellic acid (GA3), the cytokinin zeatin (Z), and indole-3-acetic acid (IAA). Suv3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


:

Pssm-ID: 350671 [Multi-domain]  Cd Length: 142  Bit Score: 299.47  E-value: 3.16e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380  69 RKIIFHSGPTNSGKTYHAIQKYFSAKSGVYCGPLKLLAHEIFEKSNAAGVPCDLVTGEERVTVQPngkqASHVSCTVEMC 148
Cdd:cd17913     1 RKIIFHAGPTNSGKTYHALQRLKSAKSGVYCGPLRLLAWEVYERLNAEGVPCDLVTGQERREVEG----ATHVSCTVEMA 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1021312380 149 SVTTPYEVAVIDEIQMIRDPARGWAWTRALLGLCAEEVHLCGEPAAIDLVMELMYTTGEEVEVRDY 214
Cdd:cd17913    77 SISEPYDVAVIDEIQMIGDPQRGWAWTRALLGLPAEEIHLCGDPSALPLVRKLAETTGDELEVREY 142
SF2_C_suv3 cd18805
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene ...
 218-356 5.00e-80

C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene encodes a DNA and RNA helicase, which is localized in mitochondria and is a subunit of the degradosome complex involved in regulation of RNA surveillance and turnover. SUV3 exhibits DNA and RNA-dependent ATPase, DNA and RNA-binding and DNA and RNA unwinding activities. SUV3 is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


:

Pssm-ID: 350192 [Multi-domain]  Cd Length: 135  Bit Score: 249.78  E-value: 5.00e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380 218 TPISVLDHALESLDNLRPGDCIVCFSKNDIYSVSRQIEIR-GLESAVIYGSLPPGTKLAQAKKFNDPNDPCKILVATDAI 296
Cdd:cd18805     1 TPLSVESKPLGSLRNLRPGDCVVAFSRKDIFSLKREIEKRtGLKCAVIYGALPPETRRQQARLFNDPESGYDVLVASDAI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380 297 GMGLNLSIRRIIFYSLIKPSINekgerELEPITTSQALQIAGRAGRFSSRFKEGEVTTMN 356
Cdd:cd18805    81 GMGLNLNIRRVIFSSLSKFDGN-----EMRPLSPSEVKQIAGRAGRFGSHFPEGEVTTLR 135
Suv3_N super family cl39503
Suv3 helical N-terminal domain; This is the N-terminal domain of Suv3 present in Homo sapiens. ...
 1-48 1.18e-24

Suv3 helical N-terminal domain; This is the N-terminal domain of Suv3 present in Homo sapiens. Suv3 is an NTP-dependent RNA/DNA helicase that is necessary for the degradation of mature mtRNAs. Suv3 has been found to interact in vitro with polynucleotide phosphorylase.


The actual alignment was detected with superfamily member pfam18114:

Pssm-ID: 436283  Cd Length: 116  Bit Score: 98.94  E-value: 1.18e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1021312380   1 MQSHSLDVDIHIVLNDICFGAAHADDLFPFFLRHAKQIFPVLDCKDDL 48
Cdd:pfam18114  69 LESESLPVDLHILLSDIIKGGGHVDDLFPYFLRHAKQVFPHLECMDDL 116
Suv3_C_1 pfam18147
Suv3 C-terminal domain 1; This domain is found in Suv3 present in Homo sapiens. Suv3 is an ...
 427-467 2.46e-15

Suv3 C-terminal domain 1; This domain is found in Suv3 present in Homo sapiens. Suv3 is an NTP-dependent RNA/DNA helicase that is necessary for the degradation of mature mtRNAs. Suv3 has been found to interact in vitro with polynucleotide phosphorylase. This domain makes up part of the C-terminal domain.


:

Pssm-ID: 436308  Cd Length: 41  Bit Score: 70.16  E-value: 2.46e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1021312380 427 AELIQHIPLSLRVRYVFCTAPINKKQPFVCSSLLQFARQYS 467
Cdd:pfam18147   1 ADLIQPVPLSLRDRYTFCMAPVNTRDPKAVAALVEFARCYA 41
SUV3_C pfam12513
Mitochondrial degradasome RNA helicase subunit C terminal; This domain family is found in ...
 495-541 5.79e-15

Mitochondrial degradasome RNA helicase subunit C terminal; This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length. The family is found in association with pfam00271. The yeast mitochondrial degradosome (mtEXO) is an NTP-dependent exoribonuclease involved in mitochondrial RNA metabolism. mtEXO is made up of two subunits: an RNase (DSS1) and an RNA helicase (SUV3). These co-purify with mitochondrial ribosomes.


:

Pssm-ID: 463616  Cd Length: 47  Bit Score: 69.08  E-value: 5.79e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1021312380 495 MDLEAVHDVLDLYLWLSYRFMDMFPDASLIRDLQKELDGIIQDGVHN 541
Cdd:pfam12513   1 ERLESLHKVLDLYLWLSYRFPEVFPDRELAEELKKLVEEKIEEGLER 47
 
Name Accession Description Interval E-value
DEXQc_Suv3 cd17913
DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA ...
 69-214 3.16e-99

DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA unwinding enzyme belonging to the class of DexH-box helicases. It localizes predominantly in the mitochondria, where it forms an RNA-degrading complex called mitochondrial degradosome (mtEXO) with exonuclease PNP (polynucleotide phosphorylase), that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Suv3 plays a role in the RNA surveillance system in mitochondria; it regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. It also confers salinity and drought stress tolerance by maintaining both photosynthesis and antioxidant machinery, probably via an increase in plant hormone levels such as gibberellic acid (GA3), the cytokinin zeatin (Z), and indole-3-acetic acid (IAA). Suv3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350671 [Multi-domain]  Cd Length: 142  Bit Score: 299.47  E-value: 3.16e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380  69 RKIIFHSGPTNSGKTYHAIQKYFSAKSGVYCGPLKLLAHEIFEKSNAAGVPCDLVTGEERVTVQPngkqASHVSCTVEMC 148
Cdd:cd17913     1 RKIIFHAGPTNSGKTYHALQRLKSAKSGVYCGPLRLLAWEVYERLNAEGVPCDLVTGQERREVEG----ATHVSCTVEMA 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1021312380 149 SVTTPYEVAVIDEIQMIRDPARGWAWTRALLGLCAEEVHLCGEPAAIDLVMELMYTTGEEVEVRDY 214
Cdd:cd17913    77 SISEPYDVAVIDEIQMIGDPQRGWAWTRALLGLPAEEIHLCGDPSALPLVRKLAETTGDELEVREY 142
SF2_C_suv3 cd18805
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene ...
 218-356 5.00e-80

C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene encodes a DNA and RNA helicase, which is localized in mitochondria and is a subunit of the degradosome complex involved in regulation of RNA surveillance and turnover. SUV3 exhibits DNA and RNA-dependent ATPase, DNA and RNA-binding and DNA and RNA unwinding activities. SUV3 is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350192 [Multi-domain]  Cd Length: 135  Bit Score: 249.78  E-value: 5.00e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380 218 TPISVLDHALESLDNLRPGDCIVCFSKNDIYSVSRQIEIR-GLESAVIYGSLPPGTKLAQAKKFNDPNDPCKILVATDAI 296
Cdd:cd18805     1 TPLSVESKPLGSLRNLRPGDCVVAFSRKDIFSLKREIEKRtGLKCAVIYGALPPETRRQQARLFNDPESGYDVLVASDAI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380 297 GMGLNLSIRRIIFYSLIKPSINekgerELEPITTSQALQIAGRAGRFSSRFKEGEVTTMN 356
Cdd:cd18805    81 GMGLNLNIRRVIFSSLSKFDGN-----EMRPLSPSEVKQIAGRAGRFGSHFPEGEVTTLR 135
Dob10 COG4581
Superfamily II RNA helicase [Replication, recombination and repair];
64-375 1.45e-31

Superfamily II RNA helicase [Replication, recombination and repair];


Pssm-ID: 443638 [Multi-domain]  Cd Length: 751  Bit Score: 130.83  E-value: 1.45e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380  64 ARAM-QRKIIFHSGPTNSGKTYHAIQKYFSA----KSGVYCGPLKLLAHEIFEKSNAA--GVPCDLVTGEERVtvqpNGk 136
Cdd:COG4581    34 ILALeAGRSVLVAAPTGSGKTLVAEFAIFLAlargRRSFYTAPIKALSNQKFFDLVERfgAENVGLLTGDASV----NP- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380 137 QASHVSCTVEM--------CSVTTPYEVAVIDEIQMIRDPARGWAWTRALLGLcAEEVHLCGEPAAI----DLVMELMYT 204
Cdd:COG4581   109 DAPIVVMTTEIlrnmlyreGADLEDVGVVVMDEFHYLADPDRGWVWEEPIIHL-PARVQLVLLSATVgnaeEFAEWLTRV 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380 205 TGEEVEVRDYKR-------------LTPISVLDHAL-------ESLDNLRPGDC----IVCFS----------------- 243
Cdd:COG4581   188 RGETAVVVSEERpvplefhylvtprLFPLFRVNPELlrppsrhEVIEELDRGGLlpaiVFIFSrrgcdeaaqqllsarlt 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380 244 ---------------KNDIYSVSRQIEIRGLES--AVIYGSLPPGTK-----LAQAKKfndpndpCKILVATDAIGMGLN 301
Cdd:COG4581   268 tkeeraeireaidefAEDFSVLFGKTLSRLLRRgiAVHHAGMLPKYRrlveeLFQAGL-------LKVVFATDTLAVGIN 340

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1021312380 302 LSIRRIIFYSLIKpsINEKGERelePITTSQALQIAGRAGRfssR--FKEGEVTTM--NHEDLSLLKEILKRPVDPIR 375
Cdd:COG4581   341 MPARTVVFTKLSK--FDGERHR---PLTAREFHQIAGRAGR---RgiDTEGHVVVLapEHDDPKKFARLASARPEPLR 410
Suv3_N pfam18114
Suv3 helical N-terminal domain; This is the N-terminal domain of Suv3 present in Homo sapiens. ...
 1-48 1.18e-24

Suv3 helical N-terminal domain; This is the N-terminal domain of Suv3 present in Homo sapiens. Suv3 is an NTP-dependent RNA/DNA helicase that is necessary for the degradation of mature mtRNAs. Suv3 has been found to interact in vitro with polynucleotide phosphorylase.


Pssm-ID: 436283  Cd Length: 116  Bit Score: 98.94  E-value: 1.18e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1021312380   1 MQSHSLDVDIHIVLNDICFGAAHADDLFPFFLRHAKQIFPVLDCKDDL 48
Cdd:pfam18114  69 LESESLPVDLHILLSDIIKGGGHVDDLFPYFLRHAKQVFPHLECMDDL 116
Suv3_C_1 pfam18147
Suv3 C-terminal domain 1; This domain is found in Suv3 present in Homo sapiens. Suv3 is an ...
 427-467 2.46e-15

Suv3 C-terminal domain 1; This domain is found in Suv3 present in Homo sapiens. Suv3 is an NTP-dependent RNA/DNA helicase that is necessary for the degradation of mature mtRNAs. Suv3 has been found to interact in vitro with polynucleotide phosphorylase. This domain makes up part of the C-terminal domain.


Pssm-ID: 436308  Cd Length: 41  Bit Score: 70.16  E-value: 2.46e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1021312380 427 AELIQHIPLSLRVRYVFCTAPINKKQPFVCSSLLQFARQYS 467
Cdd:pfam18147   1 ADLIQPVPLSLRDRYTFCMAPVNTRDPKAVAALVEFARCYA 41
SUV3_C pfam12513
Mitochondrial degradasome RNA helicase subunit C terminal; This domain family is found in ...
 495-541 5.79e-15

Mitochondrial degradasome RNA helicase subunit C terminal; This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length. The family is found in association with pfam00271. The yeast mitochondrial degradosome (mtEXO) is an NTP-dependent exoribonuclease involved in mitochondrial RNA metabolism. mtEXO is made up of two subunits: an RNase (DSS1) and an RNA helicase (SUV3). These co-purify with mitochondrial ribosomes.


Pssm-ID: 463616  Cd Length: 47  Bit Score: 69.08  E-value: 5.79e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1021312380 495 MDLEAVHDVLDLYLWLSYRFMDMFPDASLIRDLQKELDGIIQDGVHN 541
Cdd:pfam12513   1 ERLESLHKVLDLYLWLSYRFPEVFPDRELAEELKKLVEEKIEEGLER 47
HELICc smart00490
helicase superfamily c-terminal domain;
250-343 7.59e-14

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 67.24  E-value: 7.59e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380  250 VSRQIEIRGLESAVIYGSLPPGTKLAQAKKFNdpNDPCKILVATDAIGMGLNL-SIRRIIFYSLikpsinekgerelePI 328
Cdd:smart00490   3 LAELLKELGIKVARLHGGLSQEEREEILDKFN--NGKIKVLVATDVAERGLDLpGVDLVIIYDL--------------PW 66

                           90
                   ....*....|....*
gi 1021312380  329 TTSQALQIAGRAGRF 343
Cdd:smart00490  67 SPASYIQRIGRAGRA 81
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 225-343 3.67e-13

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 66.08  E-value: 3.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380 225 HALESLDNLRPGDCIVCFSKNDIYSVSRQIEIR-GLESAVIYGSLPPGTKLAQAKKFNDPNdpCKILVATDAIGMGLNL- 302
Cdd:pfam00271   4 EALLELLKKERGGKVLIFSQTKKTLEAELLLEKeGIKVARLHGDLSQEEREEILEDFRKGK--IDVLVATDVAERGLDLp 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1021312380 303 SIRRIIFYSLikpsinekgerelePITTSQALQIAGRAGRF 343
Cdd:pfam00271  82 DVDLVINYDL--------------PWNPASYIQRIGRAGRA 108
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 250-302 7.11e-05

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 45.99  E-value: 7.11e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1021312380 250 VSRQIEIRGLESAVIYGSLPPGTKLAQAKKFNDPNDPCKILVATDAIGMGLNL 302
Cdd:COG0553   565 LEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNL 617
PLN03137 PLN03137
ATP-dependent DNA helicase; Q4-like; Provisional
 239-346 3.35e-03

ATP-dependent DNA helicase; Q4-like; Provisional


Pssm-ID: 215597 [Multi-domain]  Cd Length: 1195  Bit Score: 40.65  E-value: 3.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380  239 IVCFSKNDIYSVSRQIEIRGLESAVIYGSLPPGTKLAQAKKFNdpNDPCKILVATDAIGMGLNL-SIRRIIFYSLIKpSI 317
Cdd:PLN03137   685 IYCLSRMDCEKVAERLQEFGHKAAFYHGSMDPAQRAFVQKQWS--KDEINIICATVAFGMGINKpDVRFVIHHSLPK-SI 761

                           90       100
                   ....*....|....*....|....*....
gi 1021312380  318 neKGERelepittsqalQIAGRAGRFSSR 346
Cdd:PLN03137   762 --EGYH-----------QECGRAGRDGQR 777
 
Name Accession Description Interval E-value
DEXQc_Suv3 cd17913
DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA ...
 69-214 3.16e-99

DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA unwinding enzyme belonging to the class of DexH-box helicases. It localizes predominantly in the mitochondria, where it forms an RNA-degrading complex called mitochondrial degradosome (mtEXO) with exonuclease PNP (polynucleotide phosphorylase), that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Suv3 plays a role in the RNA surveillance system in mitochondria; it regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. It also confers salinity and drought stress tolerance by maintaining both photosynthesis and antioxidant machinery, probably via an increase in plant hormone levels such as gibberellic acid (GA3), the cytokinin zeatin (Z), and indole-3-acetic acid (IAA). Suv3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350671 [Multi-domain]  Cd Length: 142  Bit Score: 299.47  E-value: 3.16e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380  69 RKIIFHSGPTNSGKTYHAIQKYFSAKSGVYCGPLKLLAHEIFEKSNAAGVPCDLVTGEERVTVQPngkqASHVSCTVEMC 148
Cdd:cd17913     1 RKIIFHAGPTNSGKTYHALQRLKSAKSGVYCGPLRLLAWEVYERLNAEGVPCDLVTGQERREVEG----ATHVSCTVEMA 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1021312380 149 SVTTPYEVAVIDEIQMIRDPARGWAWTRALLGLCAEEVHLCGEPAAIDLVMELMYTTGEEVEVRDY 214
Cdd:cd17913    77 SISEPYDVAVIDEIQMIGDPQRGWAWTRALLGLPAEEIHLCGDPSALPLVRKLAETTGDELEVREY 142
SF2_C_suv3 cd18805
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene ...
 218-356 5.00e-80

C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene encodes a DNA and RNA helicase, which is localized in mitochondria and is a subunit of the degradosome complex involved in regulation of RNA surveillance and turnover. SUV3 exhibits DNA and RNA-dependent ATPase, DNA and RNA-binding and DNA and RNA unwinding activities. SUV3 is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350192 [Multi-domain]  Cd Length: 135  Bit Score: 249.78  E-value: 5.00e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380 218 TPISVLDHALESLDNLRPGDCIVCFSKNDIYSVSRQIEIR-GLESAVIYGSLPPGTKLAQAKKFNDPNDPCKILVATDAI 296
Cdd:cd18805     1 TPLSVESKPLGSLRNLRPGDCVVAFSRKDIFSLKREIEKRtGLKCAVIYGALPPETRRQQARLFNDPESGYDVLVASDAI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380 297 GMGLNLSIRRIIFYSLIKPSINekgerELEPITTSQALQIAGRAGRFSSRFKEGEVTTMN 356
Cdd:cd18805    81 GMGLNLNIRRVIFSSLSKFDGN-----EMRPLSPSEVKQIAGRAGRFGSHFPEGEVTTLR 135
Dob10 COG4581
Superfamily II RNA helicase [Replication, recombination and repair];
64-375 1.45e-31

Superfamily II RNA helicase [Replication, recombination and repair];


Pssm-ID: 443638 [Multi-domain]  Cd Length: 751  Bit Score: 130.83  E-value: 1.45e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380  64 ARAM-QRKIIFHSGPTNSGKTYHAIQKYFSA----KSGVYCGPLKLLAHEIFEKSNAA--GVPCDLVTGEERVtvqpNGk 136
Cdd:COG4581    34 ILALeAGRSVLVAAPTGSGKTLVAEFAIFLAlargRRSFYTAPIKALSNQKFFDLVERfgAENVGLLTGDASV----NP- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380 137 QASHVSCTVEM--------CSVTTPYEVAVIDEIQMIRDPARGWAWTRALLGLcAEEVHLCGEPAAI----DLVMELMYT 204
Cdd:COG4581   109 DAPIVVMTTEIlrnmlyreGADLEDVGVVVMDEFHYLADPDRGWVWEEPIIHL-PARVQLVLLSATVgnaeEFAEWLTRV 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380 205 TGEEVEVRDYKR-------------LTPISVLDHAL-------ESLDNLRPGDC----IVCFS----------------- 243
Cdd:COG4581   188 RGETAVVVSEERpvplefhylvtprLFPLFRVNPELlrppsrhEVIEELDRGGLlpaiVFIFSrrgcdeaaqqllsarlt 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380 244 ---------------KNDIYSVSRQIEIRGLES--AVIYGSLPPGTK-----LAQAKKfndpndpCKILVATDAIGMGLN 301
Cdd:COG4581   268 tkeeraeireaidefAEDFSVLFGKTLSRLLRRgiAVHHAGMLPKYRrlveeLFQAGL-------LKVVFATDTLAVGIN 340

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1021312380 302 LSIRRIIFYSLIKpsINEKGERelePITTSQALQIAGRAGRfssR--FKEGEVTTM--NHEDLSLLKEILKRPVDPIR 375
Cdd:COG4581   341 MPARTVVFTKLSK--FDGERHR---PLTAREFHQIAGRAGR---RgiDTEGHVVVLapEHDDPKKFARLASARPEPLR 410
Suv3_N pfam18114
Suv3 helical N-terminal domain; This is the N-terminal domain of Suv3 present in Homo sapiens. ...
 1-48 1.18e-24

Suv3 helical N-terminal domain; This is the N-terminal domain of Suv3 present in Homo sapiens. Suv3 is an NTP-dependent RNA/DNA helicase that is necessary for the degradation of mature mtRNAs. Suv3 has been found to interact in vitro with polynucleotide phosphorylase.


Pssm-ID: 436283  Cd Length: 116  Bit Score: 98.94  E-value: 1.18e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1021312380   1 MQSHSLDVDIHIVLNDICFGAAHADDLFPFFLRHAKQIFPVLDCKDDL 48
Cdd:pfam18114  69 LESESLPVDLHILLSDIIKGGGHVDDLFPYFLRHAKQVFPHLECMDDL 116
DEAD-like_helicase_N cd17912
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ...
 71-192 3.01e-19

N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.


Pssm-ID: 350670 [Multi-domain]  Cd Length: 81  Bit Score: 82.57  E-value: 3.01e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380  71 IIFHSGPTNSGKTYHAIQKYFSA----KSGVYCGPLKLLAHEIfeksnaagvpcdlvtgeervtvqpngkqashvsctve 146
Cdd:cd17912     1 NILHLGPTGSGKTLVAIQKIASAmssgKSVLVVTPTKLLAHEI------------------------------------- 43

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1021312380 147 mcsvttpyeVAVIDEIQMIRDPARGWAW-TRALLGLCAEEVHLCGEP 192
Cdd:cd17912    44 ---------LIVIDEIQ*ILDPAAGWAWaTRALLGLKAEKVIGVGAT 81
Suv3_C_1 pfam18147
Suv3 C-terminal domain 1; This domain is found in Suv3 present in Homo sapiens. Suv3 is an ...
 427-467 2.46e-15

Suv3 C-terminal domain 1; This domain is found in Suv3 present in Homo sapiens. Suv3 is an NTP-dependent RNA/DNA helicase that is necessary for the degradation of mature mtRNAs. Suv3 has been found to interact in vitro with polynucleotide phosphorylase. This domain makes up part of the C-terminal domain.


Pssm-ID: 436308  Cd Length: 41  Bit Score: 70.16  E-value: 2.46e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1021312380 427 AELIQHIPLSLRVRYVFCTAPINKKQPFVCSSLLQFARQYS 467
Cdd:pfam18147   1 ADLIQPVPLSLRDRYTFCMAPVNTRDPKAVAALVEFARCYA 41
SUV3_C pfam12513
Mitochondrial degradasome RNA helicase subunit C terminal; This domain family is found in ...
 495-541 5.79e-15

Mitochondrial degradasome RNA helicase subunit C terminal; This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length. The family is found in association with pfam00271. The yeast mitochondrial degradosome (mtEXO) is an NTP-dependent exoribonuclease involved in mitochondrial RNA metabolism. mtEXO is made up of two subunits: an RNase (DSS1) and an RNA helicase (SUV3). These co-purify with mitochondrial ribosomes.


Pssm-ID: 463616  Cd Length: 47  Bit Score: 69.08  E-value: 5.79e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1021312380 495 MDLEAVHDVLDLYLWLSYRFMDMFPDASLIRDLQKELDGIIQDGVHN 541
Cdd:pfam12513   1 ERLESLHKVLDLYLWLSYRFPEVFPDRELAEELKKLVEEKIEEGLER 47
HELICc smart00490
helicase superfamily c-terminal domain;
250-343 7.59e-14

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 67.24  E-value: 7.59e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380  250 VSRQIEIRGLESAVIYGSLPPGTKLAQAKKFNdpNDPCKILVATDAIGMGLNL-SIRRIIFYSLikpsinekgerelePI 328
Cdd:smart00490   3 LAELLKELGIKVARLHGGLSQEEREEILDKFN--NGKIKVLVATDVAERGLDLpGVDLVIIYDL--------------PW 66

                           90
                   ....*....|....*
gi 1021312380  329 TTSQALQIAGRAGRF 343
Cdd:smart00490  67 SPASYIQRIGRAGRA 81
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 225-343 3.67e-13

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 66.08  E-value: 3.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380 225 HALESLDNLRPGDCIVCFSKNDIYSVSRQIEIR-GLESAVIYGSLPPGTKLAQAKKFNDPNdpCKILVATDAIGMGLNL- 302
Cdd:pfam00271   4 EALLELLKKERGGKVLIFSQTKKTLEAELLLEKeGIKVARLHGDLSQEEREEILEDFRKGK--IDVLVATDVAERGLDLp 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1021312380 303 SIRRIIFYSLikpsinekgerelePITTSQALQIAGRAGRF 343
Cdd:pfam00271  82 DVDLVINYDL--------------PWNPASYIQRIGRAGRA 108
BRR2 COG1204
Replicative superfamily II helicase [Replication, recombination and repair];
75-511 7.89e-08

Replicative superfamily II helicase [Replication, recombination and repair];


Pssm-ID: 440817 [Multi-domain]  Cd Length: 529  Bit Score: 55.29  E-value: 7.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380  75 SGPTNSGKT---YHAIQKYFSAKS-GVYCGPLKLLAHEIFEKSNAA----GVPCDLVTGEeRVTVQPNGKQASHVSCTVE 146
Cdd:COG1204    44 SAPTASGKTliaELAILKALLNGGkALYIVPLRALASEKYREFKRDfeelGIKVGVSTGD-YDSDDEWLGRYDILVATPE 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380 147 MC--------SVTTPYEVAVIDEIQMIRDPARG----WAWTRAL--------LGLCA-----EEVH--LCGEPA-----A 194
Cdd:COG1204   123 KLdsllrngpSWLRDVDLVVVDEAHLIDDESRGptleVLLARLRrlnpeaqiVALSAtignaEEIAewLDAELVksdwrP 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380 195 IDLVMELMYttGEEVEVRDYKRLTPISVLDHALESLDNLrpGDCIV-CFSKNDIYSVSRQI--------------EIRGL 259
Cdd:COG1204   203 VPLNEGVLY--DGVLRFDDGSRRSKDPTLALALDLLEEG--GQVLVfVSSRRDAESLAKKLadelkrrltpeereELEEL 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380 260 ESAVI-----------------------YGSLPPGTKLAQAKKFNDPNdpCKILVATDAIGMGLNLSIRRIIFYSLikps 316
Cdd:COG1204   279 AEELLevseethtnekladclekgvafhHAGLPSELRRLVEDAFREGL--IKVLVATPTLAAGVNLPARRVIIRDT---- 352

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380 317 ineKGERElEPITTSQALQIAGRAGRFSSRFkEGE--VTTMNHEDLSLLKEI-LKRPVDPIR-----------------A 376
Cdd:COG1204   353 ---KRGGM-VPIPVLEFKQMAGRAGRPGYDP-YGEaiLVAKSSDEADELFERyILGEPEPIRsklanesalrthllaliA 427

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380 377 AGLHPTAEQIEMF------AYHLPDATLSNLIDIFVDFSQVDGqyFVcNMDDFKFSAELIQHIplslrvryvfctapink 450
Cdd:COG1204   428 SGFANSREELLDFlentfyAYQYDKGDLEEVVDDALEFLLENG--FI-EEDGDRLRATKLGKL----------------- 487

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1021312380 451 kqpfvcssllqFARQYSRnePLTFAWLRRYIKwpllppKNIKDLMDLEAVHDVLDLYLWLS 511
Cdd:COG1204   488 -----------VSRLYID--PLTAAELVDGLR------KADEEFTDLGLLHLILILRDWIN 529
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 208-310 5.40e-07

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 49.01  E-value: 5.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380 208 EVEVRDYKrltpISVLDHALESLdnLRPGDCIVCFSKN----DIysVSRQIEIRGLESAVIYGSLPPGTKLAQAKKFNDP 283
Cdd:cd18793     5 IEEVVSGK----LEALLELLEEL--REPGEKVLIFSQFtdtlDI--LEEALRERGIKYLRLDGSTSSKERQKLVDRFNED 76

                          90       100
                  ....*....|....*....|....*...
gi 1021312380 284 NDPCKILVATDAIGMGLNLSI-RRIIFY 310
Cdd:cd18793    77 PDIRVFLLSTKAGGVGLNLTAaNRVILY 104
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
 75-188 3.54e-06

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 47.64  E-value: 3.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380  75 SGPTNSGKT---YHAIQKYF--SAKSGVYCGPLKLLAHEIF----EKSNAAGVPCDLVTGEERVTVQPNGKqASHVSCTV 145
Cdd:cd17921    23 SAPTSSGKTliaELAILRALatSGGKAVYIAPTRALVNQKEadlrERFGPLGKNVGLLTGDPSVNKLLLAE-ADILVATP 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1021312380 146 EMCSVTT---------PYEVAVIDEIQMIRDPARGWAWTRALLGLCAEEVHL 188
Cdd:cd17921   102 EKLDLLLrnggerliqDVRLVVVDEAHLIGDGERGVVLELLLSRLLRINKNA 153
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 288-352 2.75e-05

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 42.69  E-value: 2.75e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1021312380 288 KILVATDAIGMGL-NLSIRRIIFYSlikpsinekgerelEPITTSQALQIAGRAGRFSSRfkEGEV 352
Cdd:cd18785    24 EILVATNVLGEGIdVPSLDTVIFFD--------------PPSSAASYIQRVGRAGRGGKD--EGEV 73
SF2_C_RecQ cd18794
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ...
 235-342 2.89e-05

C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350181 [Multi-domain]  Cd Length: 134  Bit Score: 44.12  E-value: 2.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380 235 PGDC--IVCFSKNDIYSVSRQIEIRGLESAVIYGSLPPGTKLAQAKKFNdpNDPCKILVATDAIGMGLNLS-IRRIIFYS 311
Cdd:cd18794    29 LGGSgiIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWL--RDKIQVIVATVAFGMGIDKPdVRFVIHYS 106

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1021312380 312 LikpsinekgerelePITTSQALQIAGRAGR 342
Cdd:cd18794   107 L--------------PKSMESYYQESGRAGR 123
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 250-302 7.11e-05

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 45.99  E-value: 7.11e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1021312380 250 VSRQIEIRGLESAVIYGSLPPGTKLAQAKKFNDPNDPCKILVATDAIGMGLNL 302
Cdd:COG0553   565 LEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNL 617
SF2_C_Ski2 cd18795
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ...
 288-342 1.03e-03

C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350182 [Multi-domain]  Cd Length: 154  Bit Score: 40.23  E-value: 1.03e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1021312380 288 KILVATDAIGMGLNLSIRRIIFYSLIKpsINEKGERELePITTSqaLQIAGRAGR 342
Cdd:cd18795    91 KVLVATSTLAAGVNLPARTVIIKGTQR--YDGKGYREL-SPLEY--LQMIGRAGR 140
DEXHc_archSki2 cd18028
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ...
 75-171 2.73e-03

DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350786 [Multi-domain]  Cd Length: 177  Bit Score: 39.24  E-value: 2.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380  75 SGPTNSGKTYHA----IQKYFSAKSGVYCGPLKLLAHEI---FEKSNAAGVPCDLVTGEERVTVQPNGKqaSHVsctvem 147
Cdd:cd18028    23 SIPTASGKTLIAemamVNTLLEGGKALYLVPLRALASEKyeeFKKLEEIGLKVGISTGDYDEDDEWLGD--YDI------ 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1021312380 148 csVTTPYE-----------------VAVIDEIQMIRDPARG 171
Cdd:cd18028    95 --IVATYEkfdsllrhspswlrdvgVVVVDEIHLISDEERG 133
PLN03137 PLN03137
ATP-dependent DNA helicase; Q4-like; Provisional
 239-346 3.35e-03

ATP-dependent DNA helicase; Q4-like; Provisional


Pssm-ID: 215597 [Multi-domain]  Cd Length: 1195  Bit Score: 40.65  E-value: 3.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312380  239 IVCFSKNDIYSVSRQIEIRGLESAVIYGSLPPGTKLAQAKKFNdpNDPCKILVATDAIGMGLNL-SIRRIIFYSLIKpSI 317
Cdd:PLN03137   685 IYCLSRMDCEKVAERLQEFGHKAAFYHGSMDPAQRAFVQKQWS--KDEINIICATVAFGMGINKpDVRFVIHHSLPK-SI 761

                           90       100
                   ....*....|....*....|....*....
gi 1021312380  318 neKGERelepittsqalQIAGRAGRFSSR 346
Cdd:PLN03137   762 --EGYH-----------QECGRAGRDGQR 777
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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