|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
10-441 |
0e+00 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 609.34 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 10 RTVIFISMFVGYMLYYFNRKTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGT 89
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 90 INIAFSCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIM 169
Cdd:cd17343 81 TTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 170 SVSGLICMAVAVVCLLMVKNEPSDVGLPSIQPgAKKGKGKKGGPNDESSLKDFLLSPYLWVLSAGYLVVFGVKIACTDWG 249
Cdd:cd17343 161 SISGTVAVVMSVVCLLFIKNEPSDVGLNNIEE-EESKGKKKKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVTDWG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 250 QLFLMQEKGQSAMMGSSYMSALEVGGFFGSIGAGYLSDRAVARQGLGVYGNPRHGLLLMMMAGMAVSMYLFRVTITPETP 329
Cdd:cd17343 240 QLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSSSRGNPRMPLALVFMAGLTVSLHLFRVHITSDSS 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 330 eeaplwvlalhpvsvltgvsekELWILILGAAFGFSSYGPIALFGVIASESAPSNFCGTSHAIVALMANVGAFIAGLPFS 409
Cdd:cd17343 320 ----------------------ELFILLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFS 377
|
410 420 430
....*....|....*....|....*....|..
gi 1034541960 410 TIAKRYSWDTAFWVAEVSCAITTVCFFFVRNM 441
Cdd:cd17343 378 YIAKHYDWRTAFLLLEILCAITVVILFLLRNI 409
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
18-421 |
9.44e-116 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 344.36 E-value: 9.44e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 18 FVGYMLYYFNRKTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGTINIAFSCS 97
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 98 STVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGP-IITTVLVQYYDWRVIMSVSGLIC 176
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPpLVLFGIAELYSWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 177 MAVAVVCLLMVKNEPSDVGLPSIQPGAKKGKGKKGGPNDESSLKD------FLLSPYLWVLSAGYLVVFGVKIACTDWGQ 250
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCGLPPAEEMPNEEPDGDAEKKEEELTKKqiflqyVLLNKVLWYISLGYVFVYVVRTGILDWSP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 251 LFLMQEKGQSAMMGSSYMSALEVGGFFGSIGAGYLSDRavarqglgVYGNPRHGLLLMMMAGMAVSMYLFRVTitpetpe 330
Cdd:TIGR00881 241 LYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDK--------LFNGRRGPLAVFFMALIIVSLLVYWLN------- 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 331 eaplwvlalhpvsvltgVSEKELWILILGAAFGFSSYGPIALFGVIASESAPSNFCGTSHAIVALMANVGAFIAGLPFST 410
Cdd:TIGR00881 306 -----------------PAANPLMDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGY 368
|
410
....*....|.
gi 1034541960 411 IAKRYSWDTAF 421
Cdd:TIGR00881 369 LADGFGWAGAF 379
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
10-439 |
2.01e-101 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 307.28 E-value: 2.01e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 10 RTVIFISMFVGYMLYYFNRKTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGT 89
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 90 INIAFSCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIM 169
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 170 SVSGLICMAVAVVCLLMVKNEPsdvglpsiqpgakkgkgkkggpndesslkdfllsPYLWVLSAGYLVVFGVKIACTDWG 249
Cdd:cd17312 161 LVPGIVGLVVAIILFFFLRDSP----------------------------------PYVWVLSLAYAFVYIVRYACLDWG 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 250 QLFLMQEKGQSAMMGSSYMSALEVGGFFGSIGAGYLSDRavarqglgVYGNPRHGLLLMMMAGMAVSMYLFRVtitpetp 329
Cdd:cd17312 207 PLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDK--------LFGGRRAPIAVIYMLLMTLSLALFWF------- 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 330 eeaplwvlalhpvsvltgVSEKELWILILGAAFGFSSYGPIALFGVIASESAPSNF-CGTSHAIVALMANVGAFIAGLPF 408
Cdd:cd17312 272 ------------------FPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKEaAGTATGFVGLFGYLGASLAGLPL 333
|
410 420 430
....*....|....*....|....*....|.
gi 1034541960 409 STIAKRYSWDTAFWVAEVSCAITTVCFFFVR 439
Cdd:cd17312 334 GYIIDHYGWSTVFYFLISAALLSVLLLLSLW 364
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
4-430 |
2.71e-76 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 244.62 E-value: 2.71e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 4 AGYGYYRTVIFISMFVGYMLYYFNRKTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIG 83
Cdd:PRK11663 15 ARYRYWRRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 84 LFIVGTINIAFSCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYY 163
Cdd:PRK11663 95 LIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALHY 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 164 DWRVIMSVSGLICMAVAVVCLLMVKNEPSDVGLPSI------QPGAKKGKGKKGGPNDESSLKDFLLSPYLWVLSAGYLV 237
Cdd:PRK11663 175 GWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVgewrhdALELAQQQEGAGLSRKEILTKYVLLNPYIWLLSFSYVL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 238 VFGVKIACTDWGQLFLMQEKGQSAMMGSSYMSALEVGGFFGSIGAGYLSDRavarqglgVYGNPRHGLLLMMMAGMAVSM 317
Cdd:PRK11663 255 VYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDK--------LFNGNRGPMNLIFAAGILLSV 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 318 ylfrvtitpetpeeAPLWVLALHPVSVLTGvsekelwiliLGAAFGFSSYGPIALFGVIASESAPSNFCGTSHAIVALMA 397
Cdd:PRK11663 327 --------------GSLWLMPFASYVMQAA----------CFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFA 382
|
410 420 430
....*....|....*....|....*....|...
gi 1034541960 398 NVGAFIAGLPFSTIAKRYSWDTAFWVAEVSCAI 430
Cdd:PRK11663 383 YLGAALSGYPLAKVLEIWHWTGFFVVISIAAGI 415
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
10-435 |
2.81e-73 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 234.61 E-value: 2.81e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 10 RTVIFISMFVGYMLYYFNRKTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGT 89
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 90 INIAFSCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIM 169
Cdd:cd17488 81 INILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 170 SVSGLICMAVAVVCLLMVKNEPsdvglpsiqpgakkgkgkkggpndesslkdfllsPYLWVLSAGYLVVFGVKIACTDWG 249
Cdd:cd17488 161 YVPGIIAILMGIVLCWRLRDRP----------------------------------PYIWLLAFCYVLVYVVRTAINDWG 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 250 QLFLMQEKGQSAMMGSSYMSALEVGGFFGSIGAGYLSDRavarqglgVYGNPRHGLLLMMMAGMAVSMylfrvtitpetp 329
Cdd:cd17488 207 NLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDK--------LFKGNRGPMNLIFALGLLVSV------------ 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 330 eeAPLWVLALHPVSVLTgvsekelwilILGAAFGFSSYGPIALFGVIASESAPSNFCGTSHAIVALMANVGAFIAGLPFS 409
Cdd:cd17488 267 --GALWLVPVHSYWLLA----------TCFFTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYLGAALAGYPLA 334
|
410 420
....*....|....*....|....*.
gi 1034541960 410 TIAKRYSWDTAFWVAEVSCAITTVCF 435
Cdd:cd17488 335 KVIESWGWSGFFIVISIAAAISGLLL 360
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
10-439 |
5.00e-64 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 212.10 E-value: 5.00e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 10 RTVIFISMFVGYMLYYFNRKTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGT 89
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 90 INIAF----SCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYY-- 163
Cdd:cd17345 81 INILIgfvpSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFgd 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 164 -DWRVIMSVSGLICMAVAVVCLLMVKNEPSDVGLPSIQPGAKKGKGKKGGPNDESSL-------KDFLLSPYLWVLSAGY 235
Cdd:cd17345 161 gWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKGDYPEEADGEEEEQELsaweifvKYVLKNKLLWYIAIAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 236 LVVFGVKIACTDWGQLFLMQEKGQSAMMGSSYMSALEVGGFFGSIGAGYLSDRavarqglgVYGNPRhglllmmmagmav 315
Cdd:cd17345 241 VFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDK--------LFKGRR------------- 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 316 smylfrvtitpetpeeAPLWVLALHPVSVLTGV---SEKELWILILGAAFGFSSYGPIALFGVIASESAPSNFCGTSHAI 392
Cdd:cd17345 300 ----------------APTGIIFMILVIVALIVywlAPNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGL 363
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 1034541960 393 VALMANV-GAFIAGLPFSTIAKRYSWDTAFWVAEVSCAITTVCFFFVR 439
Cdd:cd17345 364 TGLFGYLgGSVLATALIGIIVDHFGWNGGFIVLLASCILAIIFLALVA 411
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-439 |
7.71e-55 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 186.61 E-value: 7.71e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 3 AAGYGYYRTVIFISMFVGYMLYYFNRKTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSI 82
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 83 GLFIVGTINIAFSCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQY 162
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 163 YDWRVIMSVSGLICMAVAVVcllmvknepsdvglpsiqpgakkgkgkkggpndesslkdfllspYLWVLSAGYLVVFGVK 242
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALL--------------------------------------------RFWLLALAYFLVYFAL 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 243 IACTDWGQLFLMQEKGQSAMMGSSYMSALEVGGFFGSIGAGYLSDRavarqglgvYGNPRHGLLLMMMAGMAVSMYLFRV 322
Cdd:COG2271 197 YGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR---------LGRRRKLVLAIGLLLAALALLLLAL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 323 TITPetpeeaplwvlalhpvsvltgvsekeLWILILGAAFGFSSYGPIALFGVIASESAPSNFCGTSHAIVALMANVGAF 402
Cdd:COG2271 268 LPSP--------------------------ALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGA 321
|
410 420 430
....*....|....*....|....*....|....*..
gi 1034541960 403 IAGLPFSTIAKRYSWDTAFWVAEVSCAITTVCFFFVR 439
Cdd:COG2271 322 LGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| glpT |
TIGR00712 |
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted ... |
4-440 |
6.61e-43 |
|
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted to span the membrane at least 8 times. The two members confirmed experimentally as glycerol-3-phosphate transporters, from E. coli and B. subtilis, share more than 50 % amino acid identity. Proteins of the hexose phosphate and phosphoglycerate transport systems are also quite similar. [Transport and binding proteins, Other]
Pssm-ID: 129795 [Multi-domain] Cd Length: 438 Bit Score: 156.93 E-value: 6.61e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 4 AGYGYYRTVIFISMFVGYMLYYFNRKTFSFLMPSVMEEiELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIG 83
Cdd:TIGR00712 19 PTYKRLRWQVFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSKGELGFALSAISIAYGFSKFIMGSVSDRSNPRVFLPAG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 84 LFIVGTINIAFS----CSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGS-LGPIITTV 158
Cdd:TIGR00712 98 LILSAAVMLLMGfvpwATSSIAIMFVLLFLNGWFQGMGWPPCGRTMVHWWSQSERGTIVSIWNCAHNIGGGiPPLLVLLG 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 159 LVQYYDWRVIMSVSGLICMAVAVVCLLMVKNEPSDVGLPSIQ------PGAKKGKGKKGGPNDESSLKDFLLSPYLWVLS 232
Cdd:TIGR00712 178 MAWFNDWHAALYFPAICAIIVALFAFAMMRDTPQSCGLPPIEeyrndyPDDYNEKAEQELTAKEIFMQYVLPNKLLWYIA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 233 AGYLVVFGVKIACTDWGQLFLMQEKGQSAMMGSSYMSALEVGGFFGSIGAGYLSDRAV-ARQGLGvygnprhGLLLMMMA 311
Cdd:TIGR00712 258 IANVFVYLLRYGVLDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFkGNRGAT-------GVFFMTLV 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 312 GMAVSMYLFRVTITPETPeeaplwvlalhpvsvltgvsekelwiLILGAAFGFSSYGPIALFGVIASESAPSNFCGTSHA 391
Cdd:TIGR00712 331 TIAVIVYWMNPAGNPLVD--------------------------MICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAG 384
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 1034541960 392 IVALMANVGAFI-AGLPFSTIAKRYSWDTAFWVAEVSCAITTVCFFFVRN 440
Cdd:TIGR00712 385 FTGLFGYLGGSVaASAIVGYTVDFFGWDGGFMVMIGGSILAVILLIVVMI 434
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
9-439 |
8.74e-34 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 130.77 E-value: 8.74e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 9 YRTVIFISMFVGYMLYYFNRKTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVG 88
Cdd:COG2223 2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 89 TINIAFSCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVI 168
Cdd:COG2223 82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 169 MSVSGLICMAVAVVCLLMVKNEPSDVGLPSIQPGakkgkgkkggpndeSSLKDFLLSPYLWVLSAGYLVVFGVKIACTDW 248
Cdd:COG2223 162 FLILGILLLVVAVLAWLFLRDPPAGAAAAAKASL--------------RDQLEALRDPRFWLLSLLYFGTFGSFIGFSSW 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 249 GQLFLMQEKGQSAMMGSSYMSALEVGGFFGSIGAGYLSDRAvarqglgvygnPRHGLLLMMMAGMAVSMYLFrvtitpet 328
Cdd:COG2223 228 LPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI-----------GGRRVLLIVFALMALGLLLL-------- 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 329 peeaplwVLALHPVSVLTGVsekelwILILGAAFGFssyGPIALFGVIASESAPSNFcGTSHAIVALMANVGAFIAGLPF 408
Cdd:COG2223 289 -------ALALGSLWLFLVL------FLLLGLALGG---GNGAVFALVPDIFPTKNA-GAVYGLVGAAGGLGGFLGPLLF 351
|
410 420 430
....*....|....*....|....*....|..
gi 1034541960 409 STIAKRY-SWDTAFWVAEVSCAITTVCFFFVR 439
Cdd:COG2223 352 GALLDATgSYTAAFLVFAVLALVALVLTLLLY 383
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
6-438 |
5.32e-33 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 129.83 E-value: 5.32e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 6 YGYYRTVIFISMFVGYMLYYFNRKTFSFLMPSVMEEiELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLF 85
Cdd:PRK11273 23 YRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 86 IVGTINIAFS----CSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSL-GPIITTVLV 160
Cdd:PRK11273 102 LAAAVMLFMGfvpwATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLpPLLFLLGMA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 161 QYYDWRVIMSVSGLICMAVAVVCLLMVKNEPSDVGLPSIQ------PGAKKGKGKKGGPNDESSLKDFLLSPYLWVLSAG 234
Cdd:PRK11273 182 WFNDWHAALYMPAFAAILVALFAFAMMRDTPQSCGLPPIEeykndyPDDYNEKHEQELTAKQIFMQYVLPNKLLWYIAIA 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 235 YLVVFGVKIACTDWGQLFLMQEKGQSAMMGSSYMSALEVGGFFGSIGAGYLSDRAV-ARQGLGvygnprhGLLLMMMAGM 313
Cdd:PRK11273 262 NVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFrGNRGAT-------GVFFMTLVTI 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 314 AVSMYLFrvtitpeTPEEAPlwvlalhpvsvltGVSekelwiLILGAAFGFSSYGPIALFGVIASESAPSNFCGTSHAIV 393
Cdd:PRK11273 335 ATIVYWL-------NPAGNP-------------TVD------MACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFT 388
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1034541960 394 ALMANV-GAFIAGLPFSTIAKRYSWDTAFWVAEVSCAITTVCFFFV 438
Cdd:PRK11273 389 GLFGYLgGSVAASAIVGYTVDFFGWDGGFMVMIGGSILAVILLIVV 434
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
10-438 |
1.55e-27 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 112.66 E-value: 1.55e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 10 RTVIFISMFVGYMLYYFNRKTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGT 89
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 90 INIAFSCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIM 169
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 170 SVSGLICMAVAVVCLLMVKNepsdvglpsiqpgakkgkgkkggpndesslkdfllspyLWVLSAGYLVVFGVKIACTDWG 249
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYLRQ--------------------------------------VWGLALGYFGINYALYGLLTWL 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 250 QLFLMQEKGQSAMMGSSYMSALEVGGFFGSIGAGYLSDRavarqglgVYGNPRHGLLLMMMAGMAVSMYLFrvtitpetp 329
Cdd:cd17319 203 PTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDR--------LLRGARRLVIIIGLLLAAVGLLLA--------- 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 330 eeaplwVLALHPVSVLtgvsekelwILILGAAFGFSSYGPiaLFGVIASESAPSNFCGTSHAIVALMANVGAFIAglPFS 409
Cdd:cd17319 266 ------YLTTSPVVAV---------ILLSLAGFGIGAASP--VFWSLPADLLPGEAAATAGGLINSGGNLGGFVA--PLL 326
|
410 420 430
....*....|....*....|....*....|..
gi 1034541960 410 T---IAKRYSWDTAFWVAEVSCAITTVCFFFV 438
Cdd:cd17319 327 IgylVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
8-404 |
1.46e-26 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 109.68 E-value: 1.46e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 8 YYRTVIFISMFVGYMLYYFNRKTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIV 87
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 88 GTINIAFSCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRV 167
Cdd:COG2814 86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 168 IMSVSGLICMAVAVVCLLMVKNEPSDVGlpsiqpgakkgkgkkggPNDESSLKDFLLSPYLWVLSAGYLVVFGVKIACTD 247
Cdd:COG2814 166 VFLVNAVLALLALLLLLRLLPESRPAAR-----------------ARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFT 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 248 WGQLFLMQEKGQSAMMGSSYMSALEVGGFFGSIGAGYLSDRAvarqglgvygnPRHGLLLMMMAGMAVSMYLFRVTITPe 327
Cdd:COG2814 229 YLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF-----------GRRRLLLIGLLLLALGLLLLALAGSL- 296
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034541960 328 tpeeaplwvlalhpvsvltgvsekeLWILILGAAFGFSSYGPIALFGVIASESAPSNFCGTSHAIVALMANVGAFIA 404
Cdd:COG2814 297 -------------------------WLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-404 |
2.47e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 109.04 E-value: 2.47e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 17 MFVGYMLYYFNRKTFSFLMPSVM-EEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGTINIAFS 95
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 96 CSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIMSVSGLI 175
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 176 CMAVAVVCLLMVKNEPSDVGLPSIQPGAKKGkgkkggpndeSSLKDFLLSPYLWVLSAGYLVVFGVkIACTDWGQLFlMQ 255
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLI----------VAWKALLRDPVLWLLLALLLFGFAF-FGLLTYLPLY-QE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 256 EKGQSAMMGSSYMSALEVGGFFGSIGAGYLSDRAvarqglgvygnPRHGLLLMMMAGMAVSMYLFrvtitpetpeeaplw 335
Cdd:pfam07690 229 VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRL-----------GRRRRLLLALLLLILAALGL--------------- 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034541960 336 vlalhpvsVLTGVSEKELWILILGAAFGFSSYGPIALFGVIASESAPSNFCGTSHAIVALMANVGAFIA 404
Cdd:pfam07690 283 --------LLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
17-423 |
4.60e-22 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 97.31 E-value: 4.60e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 17 MFVGYMLYYFNRKTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGTINIAFSC 96
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 97 SSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIMSVSGLIC 176
Cdd:cd17475 81 VGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 177 MAVAVVCLLMVKNEPSDVGLPSIQPGAKkgkgkkggpndeSSLKDFLLSPYLWVLSAGYLVVFGVKIACTDWGQLFLMQE 256
Cdd:cd17475 161 ILAAVLFWLFYREPPAASAATESASTLL------------RSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDH 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 257 KGQSAMMGSSYMSALEVGGFFGSIGAGYLSDRAVArqglgvyGNPRHGLLLMMMAGMAVSmylfrvtitpetpeeAPLWV 336
Cdd:cd17475 229 LGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFG-------GRRRPVLVITAAIAAAAL---------------LVLSL 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 337 LALHPVSVLtgvsekelwILILGAAFGFSSYGPIALFGVIASESAPSNFCGTSHAIVALMANVGAFIAGLPF-STIAKRY 415
Cdd:cd17475 287 LSPGTPLWL---------LVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFgLLVDATH 357
|
....*...
gi 1034541960 416 SWDTAFWV 423
Cdd:cd17475 358 SYAPAWLA 365
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
17-436 |
9.13e-22 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 96.34 E-value: 9.13e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 17 MFVGYMLYYFNRKTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGTINIAFSC 96
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 97 SSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQY--YDWRVIMSVSGL 174
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 175 ICMAVAVVCLLMVKNEPSDVGLPSIQPGAKKGKgkkggpndeSSLKDFLLSPYLWVLSAGYLVVFGVKIACTDWGQLFLM 254
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVL---------KLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 255 QEKGQSAMMGSSYMSALEVGGFFGSIGAGYLSDRavarqglgvyGNPRHGLLLMMMAGMAVSMYLFRVTITPetpeeapl 334
Cdd:cd06174 232 DLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDR----------LIGRKPLLLIGLLLMALGLALLLLAPSL-------- 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 335 wvlalhpvsvltgvsekeLWILILGAAFGFSSYGPIALFGVIASESAPSNFCGTSHAIVALMANVGAFIAGLPFSTIAKR 414
Cdd:cd06174 294 ------------------LLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAA 355
|
410 420
....*....|....*....|...
gi 1034541960 415 -YSWDTAFWVAEVSCAITTVCFF 436
Cdd:cd06174 356 tFGLTGAFLVLAVLLLLAAILLL 378
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
14-295 |
4.41e-19 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 89.34 E-value: 4.41e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 14 FISMFVGYMLYYFNRKTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGTINIA 93
Cdd:PRK09556 31 YLVVFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 94 FSCS-----STVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQY-YDWRV 167
Cdd:PRK09556 111 FGASlgsgsVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWGANYfFDGHV 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 168 I--MSVSGLICMAVAVVCLLMVKNEPSDVGLPSIQPGAKKGKGKKGGPNDESSLKDF-------LLSPYLWVLSAGYLVV 238
Cdd:PRK09556 191 IgmFIFPSIIALIIGFIGLRYGSDSPEELGWGKAEEIFGEPISEEDKETESTDMTKWqifveyvLKNPVIWLLCFANIFL 270
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1034541960 239 FGVKIACTDWGQLFLMQEKGQSAMMGSSYMSALEVGGFFGSIGAGYLSDRAVARQGL 295
Cdd:PRK09556 271 YIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLANGRRAL 327
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
13-406 |
5.69e-15 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 76.24 E-value: 5.69e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 13 IFISMFVGYMLYYFNRKTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGTINI 92
Cdd:TIGR00895 18 AIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 93 AFSCSSTVMLFTVLWFVNGFGQGFGWPPCgKVLRKWFEPSQF-GTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIMSV 171
Cdd:TIGR00895 98 LCALATNVTQLLILRFLAGLGLGGLMPNL-NALVSEYAPKRFrGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 172 SGLICMAVAVVcLLMVKNEPSD---------------VGLPSIQ-PGAKKGKGKKGGPNDESSLKDFLLS-------PYL 228
Cdd:TIGR00895 177 GGIAPLLLLLL-LMRFLPESIDflvskrpetvrrivnAIAPQMQaEAQSALPEQKSTQGTKRSVFKALFQgktaritVLL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 229 WVL-SAGYLVVFGVkiacTDWGQlFLMQEKGQSAMMGSSYMSALEVGGFFGSIGAGYLSDRAvarqglgvygNPRHGLLL 307
Cdd:TIGR00895 256 WLLyFMLLVGVYFL----TNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRL----------GPRVTALL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 308 MMMAGMAVSMYLFRVTITpetpeeaplwvlalhpvsvlTGvsekelwILILGAAFGFSSYGPIALFGVIASESAPSNFCG 387
Cdd:TIGR00895 321 LLLGAVFAVLVGSTLFSP--------------------TL-------LLLLGAIAGFFVNGGQSGLYALMALFYPTAIRA 373
|
410
....*....|....*....
gi 1034541960 388 TShaiVALMANVGAFIAGL 406
Cdd:TIGR00895 374 TG---VGWAIGIGRLGAII 389
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
13-439 |
6.30e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 76.08 E-value: 6.30e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 13 IFISMFVGYMLYYfnrkTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGTINI 92
Cdd:cd17325 1 LSLALFLDMLGYG----IIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 93 AFSCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIMSVS 172
Cdd:cd17325 77 LFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 173 GLICMAVAVVCLLMVKNEPSDVGLPSIQPGakkgkgkkggpNDESSLKDFLLSPYLWVLSAGYLVVFGVKIACTDWGQLF 252
Cdd:cd17325 157 AALALLALVLALLLLPEPRPPPNKRAVSAA-----------RLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLY 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 253 LMQEKGQSAMMGSSYMSALEVGGFFGSIGAGYLSDRAvarqglgvygnPRHGLLLMMMAGMAVSMYLFRVTITpetpeea 332
Cdd:cd17325 226 AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI-----------GRKPLILIGLLLSAVALLLLPLATS------- 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 333 pLWVLALhpVSVLTGVsekelwililGAAFGFSSYGPialfgvIASESAPSNFCGTSHAIVALMANVGAFIAGLPFSTIA 412
Cdd:cd17325 288 -FWLLLL--LLALLGL----------GLGLVFPATLA------LLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLY 348
|
410 420
....*....|....*....|....*..
gi 1034541960 413 KRYSWDTAFWVAEVSCAITTVCFFFVR 439
Cdd:cd17325 349 DAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
34-406 |
1.28e-14 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 75.29 E-value: 1.28e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 34 LMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGTINIAFSCSSTVMLFTVLWFVNGFG 113
Cdd:COG2807 40 LLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 114 QGFGWPPCGKVLRKWFePSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIMSVSGLICMAVAVVCLLMVKNEPSD 193
Cdd:COG2807 120 IAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAA 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 194 VGLPSiqpgakkgkgkkggpnDESSLKDFLLSPYLWVLSAGYLVVFGVKIACTDWGQLFLmQEKGQSAMMGSSYMSALEV 273
Cdd:COG2807 199 AAAAP----------------AAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 274 GGFFGSIGAGYLSDRAVARQGLGVygnprhGLLLMMMAGMAvsmylfrvtitpetpeeaplwVLALHPVSVLTgvsekeL 353
Cdd:COG2807 262 AGIPGSLLVPLLADRLGDRRPLLL------LLGLLGLAGLL---------------------GLLLAPGSLPW------L 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1034541960 354 WILILGAAFGfssyGPIALFGVIASESAPSNfcGTSHAIVALMANVGAFIAGL 406
Cdd:COG2807 309 WAVLLGLGQG----GLFPLALTLIGLRARTP--AEAAALSGMAQSVGYLLAAL 355
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
12-187 |
1.16e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 72.22 E-value: 1.16e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 12 VIFISMFVGYMLYYFNrktFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGTIN 91
Cdd:cd17325 203 ALFLAIFVLAFAFGAL---EPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 92 IAFSCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIMSV 171
Cdd:cd17325 280 LLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLA 359
|
170
....*....|....*.
gi 1034541960 172 SGLICMAVAVVCLLMV 187
Cdd:cd17325 360 AAALLLLAAVLFLLLR 375
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
14-337 |
2.28e-13 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 71.50 E-value: 2.28e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 14 FISMFVGYMLYYFNRKTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGTINIA 93
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 94 FSCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQY-YDWRVIMSVS 172
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 173 GLICMAVAVVCLLMVKNEPSdvglpsiQPGAKKGKGKKGGPNDESSLKDFLLSPYLWVLSAGYLVVFGVKIACTDWGQLF 252
Cdd:cd17328 161 GVLGVLLAILLLLFVREPPR-------GAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 253 LMqeKGQSAMMGSSYMSALE------VGGFFGSIGAGYLSDRAVARqglgvygnPRHGLLLMMMAGMAVSMYLFRVTITP 326
Cdd:cd17328 234 FL--RAFGVGDLSSADVGLIfgaitcIAGVLGVLLGGILADRLRRK--------TPRADPLVCAVGLLAAAPFLFLALVL 303
|
330
....*....|.
gi 1034541960 327 ETPEEAPLWVL 337
Cdd:cd17328 304 ALSNLLLAWVL 314
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
28-430 |
6.03e-13 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 69.99 E-value: 6.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 28 RKTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGTINIAFSCSSTVMLFTVLW 107
Cdd:cd17355 19 RYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 108 FVNGFGQ-GFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIMSVSGLICMAVAVVCLLM 186
Cdd:cd17355 99 GLLGGGGaGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 187 VKNEPSDVGLPSIQPGAKKGKGkkggpndeSSLKDFLLSPYLWVLSAGYLVVfGVKIACTDWGQLFLMQEKGQSAMMGSS 266
Cdd:cd17355 179 LRRRPADLALRAYDDASPASPG--------STLKEALRSASFWLLALAFFLC-GFAVVGLIVHLVPYLADRGISPAAAAV 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 267 YMSALEVGGFFGSIGAGYLSDRavarqglgvyGNPRHGLLLMMMAGMAVSMYLFRVTITPetpeeaplwvlalhpvsvlt 346
Cdd:cd17355 250 ALALIGLFNIVGRLLSGWLGDR----------YSPRRLLAASYALRALGLALLLLLPFPP-------------------- 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 347 gvsekeLWILILGAAFGFSSYGPIALFGVIASESAPSNFCGTSHAIVALMANVGAFIAGLPFSTIAKRY-SWDTAFWVAE 425
Cdd:cd17355 300 ------LALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTgSYTAAWALAV 373
|
....*
gi 1034541960 426 VSCAI 430
Cdd:cd17355 374 ALGLI 378
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
10-291 |
7.73e-13 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 68.68 E-value: 7.73e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 10 RTVIFISMFVGYMLYYFNRKTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGT 89
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 90 INIAFSCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIM 169
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 170 svsgLICMAVAVVCLLMVKNEPSDVGLPSIQPGAKKGKGKKGGPNDESSLKDFLLSPYLWVLSAGYLVVFGVKIACTDWG 249
Cdd:COG0477 172 ----LINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLL 247
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1034541960 250 QLFLMQEKGQSAMMGSSYMSALEVGGFFGSIGAGYLSDRAVA 291
Cdd:COG0477 248 LALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLL 289
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
10-319 |
1.24e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 69.11 E-value: 1.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 10 RTVIFISMFVGYMLYYFNRKTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGT 89
Cdd:COG0738 6 YRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 90 INIAFSCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRkWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQY---YDWR 166
Cdd:COG0738 86 GLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVA-ALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 167 VIMSVSGLICMAVAVVCLLmvknepsdVGLPSIQPGAKKGkgkkggPNDESSLKDFLLSPYLWVLSAGYLVVFGVKIACT 246
Cdd:COG0738 165 LPYLILAVLLLLLALLFLR--------SKLPEIEEEEEEA------AGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIG 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034541960 247 DWGQLFLMQEKGQSAMMGSSYMSALEVGGFFGSIGAGYLSDRAVARQGLGVYGnprhgllLMMMAGMAVSMYL 319
Cdd:COG0738 231 DWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSA-------LLAAVGLLLALLA 296
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
10-185 |
2.40e-12 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 68.11 E-value: 2.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 10 RTVIFISMFVGYMLYYFNRKTFSFLMPSVMEE---------IELDKEE----------------LGLITSSQTLAYAISK 64
Cdd:cd17342 1 HVVVFILTFFSYALLHATRKTFSNVKPSISAEwtpsnsntsIELHEETwnanplfpsqddaalfLGVLDTIFLFSYAIGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 65 FISGVLSDRISARWLFSIGLFIVGTINIAFSCSS------TVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTW- 137
Cdd:cd17342 81 FISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTewlhfyNKYLYCILWVLNGLLQSTGWPCVVAIMGNWFGKSSRGFVl 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1034541960 138 --WAILCCSMNLAGSLgpIITTVLVQYYDWRVIMSVSGLICMAVAVVCLL 185
Cdd:cd17342 161 glWSACASVGNIIGAL--LASSVLDYGYEYAFLVTSSLLFAGAIVVFFGL 208
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
50-436 |
2.01e-11 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 65.26 E-value: 2.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 50 GLITSSQTLAYAISKFISGVLSDRISAR--WLFSIGLFIVGTINIAFSCSSTVMLftVLWFVNGFGQGFGWPPCGKVLRK 127
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRrlLLVLLLLFILGNLLAALAPSFALLL--LARALAGLAHGGFWAIAAAYAAD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 128 WFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIMSVSGLICMAVAVVCLLmvknepsdvGLPSIQPGAKKGK 207
Cdd:cd17324 115 LVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWR---------LLPSLPPKKPGSL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 208 GKKggpndeSSLKDFLLSPYLWVLSAGYLVVFGVKIACTDWGQLFLMQEKGQSAMMGSSYMSALEVGGFFGSIGAGYLSD 287
Cdd:cd17324 186 GLL------SSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLAD 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 288 RAVARQglgvygnprhglLLMMMAGMAVSMYLfrvtitpetpeeapLWVLALHPVSVLTGvsekelwILILGAAFgFSSY 367
Cdd:cd17324 260 RGGRRA------------LLIALLLLAAALLL--------------LTLLGPSPLLLLVG-------LVLWGLGF-FAAH 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034541960 368 GPIALFGVIASESAPSNFCGTSHAIVALMANVGAFIAGLPFStiakRYSWDTAFWVAEVSCAITTVCFF 436
Cdd:cd17324 306 SALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLD----HGGWAGVGWVGAALLLLALLLAL 370
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
12-188 |
8.65e-11 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 63.35 E-value: 8.65e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 12 VIFISMFVGYMLYYFNRKTFSFLMPS-VMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISAR--WLFSIGLFIVG 88
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 89 TINIAFSCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVI 168
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339
|
170 180
....*....|....*....|
gi 1034541960 169 MSVSGLICMAVAVVCLLMVK 188
Cdd:COG2271 340 FLLLAALALLAALLALLLLR 359
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
14-430 |
6.45e-10 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 60.31 E-value: 6.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 14 FISMFVGYMLYYFNRKTFSFLMPSVMEEIE--LDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGTIN 91
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 92 IAFSCSSTVMLFTVLWFVNGFGQGfGWPPCGKVLRKWFEPSQF-GTWWAILCCSMN----LAGSLGPIITTVLVQYYDWR 166
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIG-GEYPGASTYVAEFAPSKRrGFALGLLQSGWAlgalLAALVASLLIPLLSGDWGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 167 VIMSVSGLICMAVavvcllmvknepsdvglpsiqpgakkgkgkkggpndesslkdFLLSPYLWVLSAGYLVVFGVKIACT 246
Cdd:cd17316 160 ILFLIGALPALLA------------------------------------------LLLRRRTLLLILLWFFISFGYYGLT 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 247 DWGQLFLMQEKGQSAMMGSSYMSALEVGGFFGSIGAGYLSDRAvarqglgvygnPRHGLLLMMMAGMAVSMYLFrvtitp 326
Cdd:cd17316 198 TFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI-----------GRKKTLVIGLILSGILALPL------ 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 327 etpeeaplwvlalhpvsvLTGVSEKELWILILGAAFGFSSYGPIALFGVIASESAPSNFCGTSHAIVALMANVGAFIAGL 406
Cdd:cd17316 261 ------------------FYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPP 322
|
410 420
....*....|....*....|....
gi 1034541960 407 PFSTIAKRYSWDTAFWVAEVSCAI 430
Cdd:cd17316 323 LIALLLASTGGTGVPALILALLAI 346
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
35-187 |
1.57e-09 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 59.51 E-value: 1.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 35 MPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLF--SIGLFIVGTINIAFSCSSTVMLFtvLWFVNGF 112
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFltALALFTLGSLLCGLAPNLASLII--FRILQGF 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034541960 113 GQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIMsvsgLICMAVAVVCLLMV 187
Cdd:cd17503 97 GGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIF----YINLPIGILALLLA 167
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
32-288 |
1.63e-09 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 59.14 E-value: 1.63e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 32 SFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISAR--WLFSIGLFIVGTINIAFscSSTVMLFTVLWFV 109
Cdd:cd17365 19 GFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKrvLLVSVALFGLFTLLTAF--AQSVLQLALLRFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 110 NGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIMSVSG---LICMAVAVVCLLm 186
Cdd:cd17365 97 TGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGvppLILLPLLRGTLL- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 187 vknepsdvglpsiqpgakkgkgkkggpndesslkdfllspyLWVLS-AGYLVVFGVkiacTDWGQLfLMQEKGQSAMMGS 265
Cdd:cd17365 176 -----------------------------------------LWVTFfMGLLLVYLL----NSWLPK-LMVEAGYSLSQAL 209
|
250 260
....*....|....*....|...
gi 1034541960 266 SYMSALEVGGFFGSIGAGYLSDR 288
Cdd:cd17365 210 TITLLLNIGGVIGSLLLGWLADR 232
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
30-438 |
1.93e-09 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 59.16 E-value: 1.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 30 TFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIG--LFIVGTINIAFScSSTVMLFTVLW 107
Cdd:cd17353 21 AWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGgiLFGLGFILSAFA-ISLPLLFLGYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 108 FVNGFGQGFGWPPCGKVLRKWFePSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIMSVSGLICMAVAVVCLLMV 187
Cdd:cd17353 100 VLGGIGAGIGYITPVSTAVKWF-PDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLI 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 188 KNEPSDVGLPSIQPgakkgkgkkGGPNDESSLKDF-----LLSPYLWVLsagYLVVFgvkIACTdWGQLFLMQEK----- 257
Cdd:cd17353 179 RDPPKGWVPPGVDP---------LANNAENSPRDYtpremLRTPTFWLL---WLMFF---LNAT-AGLMLIGQAKpigqe 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 258 --GQSAMMGSSYMSALEVGGFFGSIGAGYLSDRavarqgLGvygnpRHGLLLMMMAGMAVSMYLFrvtitPETPEEAPLW 335
Cdd:cd17353 243 faGLDAGIAALAVSILSIFNGGGRPFWGWLSDK------IG-----RKNTLSIAFLIQGVAMFLL-----PFIGSVAVLF 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 336 VlalhpvsvltgvsekeLWILILGAAFGfssyGPIALFGVIASESAPSNFCGTSHAIVALMANVGAFIAGLPFSTIAKRY 415
Cdd:cd17353 307 V----------------LGVALIGFCYG----GGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTG 366
|
410 420
....*....|....*....|...
gi 1034541960 416 SWDTAFWVAEVSCAITTVCFFFV 438
Cdd:cd17353 367 GYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
14-421 |
8.00e-09 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 57.31 E-value: 8.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 14 FISMFVGYMLYYFNRKTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISAR--WLFSIGLFIVGTIN 91
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVrvLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 92 IAFSCSSTVMLftVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYD----WRV 167
Cdd:cd17371 81 CGFAQNYWQLL--ILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPpeiaWRV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 168 IMsVSGLICMAVAVVCLLMVKnEPsdvglPSIQPGAKKGKGKKGGPndesSLKDFLLSPYLWVLSAGYLVVFGVKIAC-- 245
Cdd:cd17371 159 LF-LLGALPALLVLFIRRFVK-EP-----PQWQAARAARRHFADRP----SLRELFSPPLLRTTLLASLLATGALGGYyg 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 246 -TDWGQLFLMQEKGQSAMMGSSYMSALEVGGFFGSIGAGYLSDRavarqglgvYGNPRHGLLLMMMAGMAVSMYLFrvti 324
Cdd:cd17371 228 iTTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADR---------IGRRNNFALFALGSAISILLYFF---- 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 325 TPETPEEaplwvlalhpvsvltgvsekelwILILGAAFGFSSYGPIALFGVIASESAPSNFCGTShaiVALMANVGAFIA 404
Cdd:cd17371 295 LPLSPTL-----------------------ILILGFPLGFFASGPFSGMGAYLTELFPTAVRATA---QGFCYNVGRIIG 348
|
410 420
....*....|....*....|
gi 1034541960 405 GL-PFST--IAKRYSWDTAF 421
Cdd:cd17371 349 ALfPFLVgfLATSGSLGTAI 368
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
17-188 |
1.01e-08 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 56.79 E-value: 1.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 17 MFVGYMLYYFNRKTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGTINIA--F 94
Cdd:cd17380 4 LFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLtpL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 95 SCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIMSVSGL 174
Cdd:cd17380 84 LAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGL 163
|
170
....*....|....
gi 1034541960 175 ICMAVAVVCLLMVK 188
Cdd:cd17380 164 LGLLWALVWLIYLP 177
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
50-186 |
1.86e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 56.06 E-value: 1.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 50 GLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGTINIAFSCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWF 129
Cdd:cd17489 34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADII 113
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1034541960 130 EPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIMSVSGLICMAVAVVCLLM 186
Cdd:cd17489 114 PPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLV 170
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
36-438 |
2.80e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 55.65 E-value: 2.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 36 PSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGTINIAFSCSSTVMLFTVLWFVNGFGQG 115
Cdd:cd17474 23 PAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 116 FGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVqYYDWRVIMSVSGLIcMAVAVVCLLMVKNEPSDVG 195
Cdd:cd17474 103 GLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAAL-IPVAFLAILFLLPEPKEKA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 196 LPSIQpgakkgkgkkggpNDESSLKDFLLSPYLWVLSAGYLVVFGVKIACTDWGQLFLMQEKGQSAMMGSSYMSALEVGG 275
Cdd:cd17474 181 KSSSA-------------TKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 276 FFGSIGAGYLSDRAVarqglgvygnPRHGLLLMMMAGMAVSMYLFRVTitpetpeEAPLWVLALhpvsvltgvsekelwI 355
Cdd:cd17474 248 ALGSLFVGRLLKKRF----------GARRILVIGLLLYALSLLLLGFV-------PSLALLLIA---------------I 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 356 LILGAAFGFSsygpIALFGVIASESAPSNFCGTSHAIVALMANVGAFIAGLPFSTIAKRYSWDTAFWVAEVSCAITTVCF 435
Cdd:cd17474 296 VLFGLGLGLN----LPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLL 371
|
...
gi 1034541960 436 FFV 438
Cdd:cd17474 372 ALL 374
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
46-194 |
8.04e-08 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 54.24 E-value: 8.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 46 KEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGTINIAFSCS-----STVMLFTVLWFVNGFGQGFGWPP 120
Cdd:cd17344 61 TELLGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLGyywniHSLWYFVVVQILAGLFQSTGWPS 140
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034541960 121 CGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQyYDWRVIMSVSGLICMAVAVVCLLMVKNEPSDV 194
Cdd:cd17344 141 VVACVGNWFGKGKRGLIMGIWNSHTSVGNILGSLIAGIFVS-SAWGLSFIVPGIIIAAMGVLVFLFLVEHPPGV 213
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
34-436 |
1.13e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 53.71 E-value: 1.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 34 LMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGTINIAFSCSSTVMLFTVLWFVNGFG 113
Cdd:cd17478 18 LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 114 QGFGWPPCGKVLRKwFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIMSVSGLICMAVAVVCLLMvknepsd 193
Cdd:cd17478 98 SAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRL------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 194 vglpsIQPGAKKGKGKKGGPNDESSLKD--FLLSPYLWVLSAGYLVVFGVKIACTdwgqlFLMQEKGQSAMMGSSYMSAL 271
Cdd:cd17478 170 -----RPLKKPEAKKAAAKSSARSTLKGvwRALLLLLIIVFLRSWVLSSLTTFLP-----FYLVQRGYSLVFAGLLLSLF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 272 EVGGFFGSIGAGYLSDravarqglgvygnpRHGLLLMMMAGMAVSMylfrvtitpetpeeAPLWVLALHPVsvltgvsek 351
Cdd:cd17478 240 LFAGAIGTLIGGPLSD--------------RFGRRRVIIASLLLAA--------------PFLLLFLLTPG--------- 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 352 eLWILILGAAFGFSSYGPIALFGVIASESAPSNFcGTSHAIVALMANVGAFIAGLPFSTIAKRYSWDTAFWVAEVSCAIT 431
Cdd:cd17478 283 -IWSYILLVLAGFLLFASFPVTVVLAQELLPGNV-GLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLG 360
|
....*
gi 1034541960 432 TVCFF 436
Cdd:cd17478 361 ALLAF 365
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
17-288 |
2.04e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 52.71 E-value: 2.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 17 MFVGYMLYYFNRKTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGTINIAFSC 96
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 97 SSTVMLFTVLWFVNGFGQGFGwPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLV-QYYDWRVIMSVSGLI 175
Cdd:cd17333 81 TPSIYLFVVLMFLAGLGAGIL-DTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLtSELSWSWAYLIIGLI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 176 CMAVAVVCLLMVKNEPSDVGLPSIQPGakkgkgkkggpNDESSLKDFLLSPYLWVLSAGYLVVFGVKIACTDWGQLFLMQ 255
Cdd:cd17333 160 YLLLAILILLTLFPELPSARNPQQSVG-----------AFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVE 228
|
250 260 270
....*....|....*....|....*....|...
gi 1034541960 256 EKGQSAMMGSSYMSALEVGGFFGSIGAGYLSDR 288
Cdd:cd17333 229 KKHVSDGLAGYLLSGFWVGITIGRLLGGPISRR 261
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
35-401 |
4.52e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 51.79 E-value: 4.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 35 MPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIG--LFIVGTINIAFScsSTVMLFTVLWFVNGF 112
Cdd:cd17321 19 LPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGlaLFGLASLLCALA--PSLAFLIAARALQGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 113 GQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIMsvsgLICMAVAVVCLLMVKNeps 192
Cdd:cd17321 97 GAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIF----LINVPIGLVALLLART--- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 193 dvglpsiqpgakkgkgkkggpndesslkdFLLSpylwvlSAGYLVVFGVKIACTDWGQLFLMQEKGQSAMMGSSYMSALE 272
Cdd:cd17321 170 -----------------------------FSGA------VLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLA 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 273 VGGFFGSIGAGYLSDRAVARQglgvygnprhgLLLMMMAGMAVSMYLFRVTITPetpeeAPLWVLAlhpvsvltgvseke 352
Cdd:cd17321 215 LAMLVAAPLAGRLADRFGPRL-----------VLVAGLLLTAVGLLLLALLGAD-----SSVWLLL-------------- 264
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1034541960 353 LWILILGAAFGFSsygpIALFGVIASESAPSNFCGTSHAIVALMANVGA 401
Cdd:cd17321 265 PGLVLLGLGLGLF----ATPLTNAALSSVPKEKAGAASGILNTARQLGG 309
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
14-190 |
5.51e-07 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 51.61 E-value: 5.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 14 FISMFVGYMLYYFNRKTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGTINIA 93
Cdd:TIGR00711 4 TIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 94 FSCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIMSVSG 173
Cdd:TIGR00711 84 CGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINV 163
|
170
....*....|....*..
gi 1034541960 174 LICMAVAVVCLLMVKNE 190
Cdd:TIGR00711 164 PIGIIVVVVAFFILPRD 180
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
11-189 |
1.51e-06 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 50.27 E-value: 1.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 11 TVIFISMFVgymlyYFNRKTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGTI 90
Cdd:cd17323 3 IISFLTFVV-----TFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 91 NIAFSCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIMS 170
Cdd:cd17323 78 QIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFW 157
|
170
....*....|....*....
gi 1034541960 171 VSGLICMAVAVVCLLMVKN 189
Cdd:cd17323 158 FLAIISGFCLILIFLFLPI 176
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
58-182 |
1.78e-06 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 47.26 E-value: 1.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 58 LAYAISKFI----SGVLSDRISARWLFSIGLFIVGTINIAFSCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQ 133
Cdd:TIGR00880 5 AGYALGQLIysplSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEE 84
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1034541960 134 FGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIMSVSGLICMAVAVV 182
Cdd:TIGR00880 85 RGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFIL 133
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
45-187 |
4.07e-06 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 48.77 E-value: 4.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 45 DKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGTIN--IAFSCSSTVMLFTVLWFVNGFGQGFGWPPCG 122
Cdd:cd17318 54 SEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTllTPLAARGGYGALIVLRILQGLAQGVTFPAMH 133
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034541960 123 KVLRKWFEPSQFGTwwaiLCCSMNLAGSLGPIITT----VLVQYYDWRVIMSVSGLICMAVAVVCLLMV 187
Cdd:cd17318 134 ALWAKWAPPLERSR----LTSIAYSGSQFGTVIAMplsgFLCESLGWPSIFYIFGGLGLLWCLLWFFLV 198
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
12-186 |
6.54e-06 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 47.93 E-value: 6.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 12 VIFISMFVGYMLYYFNRKTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGT-I 90
Cdd:cd17352 3 VVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALgL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 91 NIAFSCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEpSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIMS 170
Cdd:cd17352 83 LLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFE-KKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALL 161
|
170
....*....|....*.
gi 1034541960 171 VSGLICMAVAVVCLLM 186
Cdd:cd17352 162 ILGGLCLNLCVCGLLL 177
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
11-186 |
7.60e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.95 E-value: 7.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 11 TVIFISMFVGYMLYYfnrkTFSFLMPSVMEEIEL-DKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGT 89
Cdd:cd17473 200 LPIYFLAFLAMLLFY----VIPIQLPFLLQERGGgSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMAL 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 90 INIAFSCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYY-DWRVI 168
Cdd:cd17473 276 GFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTgGLSGA 355
|
170
....*....|....*...
gi 1034541960 169 MSVSGLICMAVAVVCLLM 186
Cdd:cd17473 356 FLILGVLALVLAIVLLLL 373
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
58-320 |
1.17e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 47.19 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 58 LAYAISKFISGVLSDRISAR--WLFSIGLFIVGTINIAFScsSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFG 135
Cdd:cd17320 45 LGFALGQLLYGPLSDRFGRRpvLLAGLLLFILASLLCALA--SSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 136 TWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIMSVSGLICMAVAVVCLLmvknepsdvGLPSIQPGAKKGKGKKGGPnd 215
Cdd:cd17320 123 KIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLL---------FLPETLPEEKRKPLLSSLL-- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 216 eSSLKDFLLSPYLWVLSAGYLVVFGVKIACTDWGQLFLMQEKGQSAMMGSSYMSALEVGGFFGSIGAGYLSDRAVARQGL 295
Cdd:cd17320 192 -RAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLL 270
|
250 260
....*....|....*....|....*
gi 1034541960 296 gvygnpRHGLLLMMMAGMAVSMYLF 320
Cdd:cd17320 271 ------RLGLLLLLAAALVLLLAAL 289
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
1-185 |
1.33e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 47.18 E-value: 1.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 1 MGAAGYGYYRTVIFisMFVGYMLYYFNRKTFSFLMPSVM-EEIELDKEELGLITSSQTLAYAISKFISGVLSDRI---SA 76
Cdd:cd17319 170 LAVLWWFYLRQVWG--LALGYFGINYALYGLLTWLPTYLkQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgAR 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 77 RWLFSIGLFIVGTINIAFSCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIIT 156
Cdd:cd17319 248 RLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLI 327
|
170 180 190
....*....|....*....|....*....|
gi 1034541960 157 TVLVQY-YDWRVIMSVSGLiCMAVAVVCLL 185
Cdd:cd17319 328 GYLVDAtGSYTAAFLFLAA-VALLAALLVL 356
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
12-185 |
1.56e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.84 E-value: 1.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 12 VIFISMFvgymlyyFNRKTFSFLMPSVM----EEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIV 87
Cdd:cd17329 3 VLLIGSF-------LNRLGFFMVWPFMAiylhQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 88 GTINIAFSCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYdwrv 167
Cdd:cd17329 76 ALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYS---- 151
|
170
....*....|....*...
gi 1034541960 168 imsvSGLICMAVAVVCLL 185
Cdd:cd17329 152 ----FRLLFLAAAVLFLL 165
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
11-186 |
1.60e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 46.80 E-value: 1.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 11 TVIFISMFVGYMLYYfnrkTFSFLMPSVMEEI-ELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGT 89
Cdd:cd17503 181 TLGLLLSFLLGLGLF----GAMFLLPLYLQNVlGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLAL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 90 INIAFSC---SSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWR 166
Cdd:cd17503 257 GTLLLAFltpDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRTQF 336
|
170 180
....*....|....*....|
gi 1034541960 167 VIMSVSGLICMAVAVVCLLM 186
Cdd:cd17503 337 HHSRLSELLAQQVQKQALII 356
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
38-186 |
2.06e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.45 E-value: 2.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 38 VMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGTINIAFSCSSTVMLFTVLWFVNGFGQGFG 117
Cdd:cd06173 235 AKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLF 314
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034541960 118 WPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIMSVSGLICMAVAVVCLLM 186
Cdd:cd06173 315 NVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
49-433 |
5.37e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 45.30 E-value: 5.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 49 LGLITSSQTLAYAISKFISGVLSDRISARWL------FSIGLFIVGTINIAFSCSSTVMLFTVLwFVNGFGQGFGWPPCG 122
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladlLRALLAAVLALLALLGSLSLWLLLVLA-FLLGIASAFFGPARQ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 123 KVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIMSVSGLICMAVAVVCLLMVKNEPSDVGLPSIQPG 202
Cdd:cd06173 115 ALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 203 AKKgkgkkggpndESSLKDFLLSPYLWVLSAGYLVVFGVKIACTDWGQLFLMQEKGQSAMMGSSYMSALEVGGFFGSIGA 282
Cdd:cd06173 195 RDL----------REGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 283 GYLSdravarqglgvygnPRHGLLLMMMAGMAVSMylfrvtitpetpeeAPLWVLALHPVSVLTGVsekelWILILGAAF 362
Cdd:cd06173 265 GRLS--------------KRRRRGRLLLIGALLLG--------------LALLVLGLSPSLWLLLA-----ALFLLGLAG 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034541960 363 GFSsygpIALFGVIASESAPSNFCGTSHAIVALMANVGAFIAGLPFSTIAKRYSWDTAFWVAEVSCAITTV 433
Cdd:cd06173 312 GLF----NVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAAL 378
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
13-186 |
8.32e-05 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 44.47 E-value: 8.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 13 IFISMFVGYMLYYFNRKTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDR--ISARWLFSIGLFIVGTI 90
Cdd:cd17352 184 TFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLS 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 91 N--IAFSCSSTVMLFTVLWFvnGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIIT-TVLVQYYDWRV 167
Cdd:cd17352 264 LlaFPLATTYVGLIVFSVLF--GFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAgLLRDYTGDYDA 341
|
170
....*....|....*....
gi 1034541960 168 IMSVSGLICMAVAVVCLLM 186
Cdd:cd17352 342 AFYFCGACLLLSGVLLFLL 360
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
14-433 |
1.51e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 43.78 E-value: 1.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 14 FISMFVGYMLYYfnrkTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIG--LFIVGTIN 91
Cdd:cd17341 5 WLSFFLGFMVWF----LFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASllLLLIPLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 92 IAFSCSSTVMLFTVLWFVnGFGqGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQ-------YYD 164
Cdd:cd17341 81 LALAVSSYWGLLVLGFLL-GFA-GANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGaivfdggFVG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 165 WRVIMSVSGLICMAVAVVCLLMVKNEPSDVglpsiqpgakkgkgkKGGPNDESSLKDFLLSPYLWVLSAGYLVVFGVKIA 244
Cdd:cd17341 159 WRNAFFVPGILLAIAAVLVLLFGDDLPTGK---------------ASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 245 CTDWGQLFLMQEKGQSAMMGSSYMSALEVGGFFGSIGAGYLSDRAVARqglgvygnprhGLLLMMMAGMAVSMYLFrvtI 324
Cdd:cd17341 224 FSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGR-----------RRLWWLFIVMTIGAALL---S 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 325 TPETPEEAPLWVLALhpVSVLTGVSekelwiliLGAAFGfssygpiALFGVIASESAPSnfCGTSHAIVALMANVGAFIA 404
Cdd:cd17341 290 LSLPTSGTNLVLFLA--LFVALGLG--------AGAGNG-------SVFRMVPFIFRRE--LGAVTGLVGAIGGLGGFFL 350
|
410 420 430
....*....|....*....|....*....|...
gi 1034541960 405 GLPFSTIAK-RYSWDTAFW---VAEVSCAITTV 433
Cdd:cd17341 351 PLLFGSSALmTGSGVGAFSlfgVLAVACTLLVW 383
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
14-186 |
2.45e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 42.94 E-value: 2.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 14 FISMFVGYMLYYFNRKTFSFLMPSVME-EIELDKEELGLITSSQTLAYAISKFISG-VLSDRISARWLFSIGLFIVGTIN 91
Cdd:cd17474 200 LLTFLVSAFLYFFLYFAFLTYLPFLLElLYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYALSL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 92 IAFSCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDWRVIMSV 171
Cdd:cd17474 280 LLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLV 359
|
170
....*....|....*
gi 1034541960 172 SGLICMAVAVVCLLM 186
Cdd:cd17474 360 GAAIALAAAVLLALL 374
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
49-193 |
3.21e-04 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 42.81 E-value: 3.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 49 LGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGTINIAFSCSSTVMLftVLWFVNGFGQGFGWPPC----GKV 124
Cdd:TIGR00894 78 QGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGI--ALVVFCRVIQGLAQGSVspatHKI 155
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034541960 125 LRKWFEPSQFGTWwailcCSMNLAG-SLGPII----TTVLVQYYD-WRVIMSVSGLICMAVAVVCLLMVKNEPSD 193
Cdd:TIGR00894 156 IVKWAPPKERSRL-----LGMSTSGfQLGTFIflpiSGWLCESWGgWPMIFYVFGIVGCAWSLLWFVFPADDPSI 225
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
14-119 |
5.08e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.20 E-value: 5.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 14 FISMFVGYMLYYFNRKTFSFLMPSVMEE-IELDKEELGLITSSQTLAYAISKFISGVLSDRISAR--WLFSIGLFIVGTI 90
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKkaFIIGLLLAALGLL 309
|
90 100
....*....|....*....|....*....
gi 1034541960 91 NIAFSCSSTVMLFTVLWFVNGFGQGFGWP 119
Cdd:COG2211 310 LLFFLGPGNLWLLLVLAALAGIGLGAILV 338
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
45-165 |
6.38e-04 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 41.94 E-value: 6.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 45 DKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGTIN--IAFSCSSTVMLFTVLWFVNGFGQGFGWPPCG 122
Cdd:cd17382 47 TPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNmlIPIAARVHYGCVIFVRILQGLVEGVTYPACH 126
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1034541960 123 KVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQYYDW 165
Cdd:cd17382 127 GIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGW 169
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
355-438 |
1.02e-03 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 41.11 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 355 ILILGAAFGFSSYGPIALFGVIASESAPSNFCGTSHAIVALMANVGAFIAGLPFSTIAKRYSWDTAFWVAEVSCAITTVC 434
Cdd:cd17364 302 FVLYGLTFFFSNFGPNTTTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFLSLTQNIGVRNVLIILAGVALLGIIL 381
|
....
gi 1034541960 435 FFFV 438
Cdd:cd17364 382 TLLF 385
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
58-180 |
1.35e-03 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 40.66 E-value: 1.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 58 LAYAISKFISGVLSDRISAR--WLFSIGLFIVGTINIAFSCSSTVMLftVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFG 135
Cdd:PRK11652 54 LTYGLSQLFYGPLSDRVGRRpvILVGMSIFILGTLVALFAHSLTVLI--AASAIQGLGTGVGGVMARTLPRDLYEGTQLR 131
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1034541960 136 TWWAILccSMNLAGS--LGPIITTVLVQYYDWRVIMSVSGLICMAVA 180
Cdd:PRK11652 132 HANSLL--NMGILVSplLAPLIGGLLTTLFGWRACYLFLLLLGAGVT 176
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
7-99 |
2.26e-03 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 40.42 E-value: 2.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 7 GYYRTVIFISMFVGYML----YYFNRKTFSFLMPSVMEEIElDKEELGLITSSQTLAYAISKFISGVLSDRISARwLFSI 82
Cdd:pfam06609 35 GYYRSPRIIASFAAFSLnvcaTYFVLQASASALPNILQDIG-QSENQGLFSTLWTMGQAVSILMMGRLTDRFGRR-PFVI 112
|
90
....*....|....*..
gi 1034541960 83 GLFIVGTINIAFSCSST 99
Cdd:pfam06609 113 ATHIIGLVGAIVGCTAN 129
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
12-184 |
3.87e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.12 E-value: 3.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 12 VIFISMFVGYMLYYfnrkTFSFLMPSVMEEIE-LDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFI--VG 88
Cdd:cd17316 181 LLILLWFFISFGYY----GLTTFLPTYLQTVLgLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILsgIL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 89 TINIAFSCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAIlccSMNLAGSLG----PIITTVLVQYYD 164
Cdd:cd17316 257 ALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGL---SYNLGRLGGggapPLIALLLASTGG 333
|
170 180
....*....|....*....|
gi 1034541960 165 WRVIMSVSGLICMAVAVVCL 184
Cdd:cd17316 334 TGVPALILALLAIVALIVAL 353
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
2-153 |
4.91e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.94 E-value: 4.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 2 GAAGYGYYRTVIFISMFVGYMLYYFNRKTFSFLMPSVMEEIELDKEELGLITSSQTLAYAISKFISGVLSDRISAR--WL 79
Cdd:pfam07690 190 LIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRrrLL 269
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034541960 80 FSIGLFIVGTINIAFSC-SSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGP 153
Cdd:pfam07690 270 LALLLLILAALGLLLLSlTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
12-193 |
8.32e-03 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 38.38 E-value: 8.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 12 VIFISMFVGYMLYYFNRKTFSFLMPSVM-EEIELDKEELGLITSSQTLAYAISKFISGVLSDRISARWLFSIGLFIVGTI 90
Cdd:cd17327 5 FILPLLCILYFLQYLDKSNISNAAVMGMkEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034541960 91 NIAFSCSSTVMLFTVLWFVNGFGQGFGWPPCGKVLRKWFEPSQFGTWWAILCCSMNLAGSLGPIITTVLVQY------YD 164
Cdd:cd17327 85 TLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKIlgvgglAG 164
|
170 180
....*....|....*....|....*....
gi 1034541960 165 WRVIMSVSGLICMAVAVVCLLMVKNEPSD 193
Cdd:cd17327 165 WRWLFIIEGLITIIIGLVIFFWLPDNPSK 193
|
|
| |
