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Conserved domains on  [gi|1043261390|ref|NP_001316354|]
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ral-GDS-related protein isoform 3 [Homo sapiens]

Protein Classification

RasGEF domain-containing protein( domain architecture ID 940)

RasGEF domain-containing protein may function as a guanine nucleotide exchange factor for Ras-like small GTPases

CATH:  1.10.840.10
Gene Ontology:  GO:0005085|GO:0007264
PubMed:  10431174|7786285
SCOP:  4001268

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RasGEF super family cl02485
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of ...
 5-88 4.72e-13

Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. Guanine-nucleotide-exchange factors (GEFs) positively regulate these GTP-binding proteins in response to a variety of signals. GEFs catalyze the dissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors.


The actual alignment was detected with superfamily member cd00155:

Pssm-ID: 470590 [Multi-domain]  Cd Length: 237  Bit Score: 61.88  E-value: 4.72e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043261390   5 RQKKGVVPFLGDFLTELQRLDSAIPDDLDGNT---NKRSKEVRVLQEMQLLQVAamNYRLRPLEKFVTYFT--RMEQLSD 79
Cdd:cd00155   151 GPNPPCVPFLGVYLKDLTFLHEGNPDFLEGNLvnfEKRRKIAEILREIRQLQSN--SYELNRDEDILAFLWklLELILNE 228


                  ....*....
gi 1043261390  80 KESYKLSCQ 88
Cdd:cd00155   229 DELYELSLE 237
 
Name Accession Description Interval E-value
RasGEF cd00155
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of ...
 5-88 4.72e-13

Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. Guanine-nucleotide-exchange factors (GEFs) positively regulate these GTP-binding proteins in response to a variety of signals. GEFs catalyze the dissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors.


Pssm-ID: 238087 [Multi-domain]  Cd Length: 237  Bit Score: 61.88  E-value: 4.72e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043261390   5 RQKKGVVPFLGDFLTELQRLDSAIPDDLDGNT---NKRSKEVRVLQEMQLLQVAamNYRLRPLEKFVTYFT--RMEQLSD 79
Cdd:cd00155   151 GPNPPCVPFLGVYLKDLTFLHEGNPDFLEGNLvnfEKRRKIAEILREIRQLQSN--SYELNRDEDILAFLWklLELILNE 228


                  ....*....
gi 1043261390  80 KESYKLSCQ 88
Cdd:cd00155   229 DELYELSLE 237
RasGEF smart00147
Guanine nucleotide exchange factor for Ras-like small GTPases;
7-91 9.81e-12

Guanine nucleotide exchange factor for Ras-like small GTPases;


Pssm-ID: 214539  Cd Length: 242  Bit Score: 58.41  E-value: 9.81e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043261390    7 KKGVVPFLGDFLTELQRLDSAIPDDLDG---NTNKRSKEVRVLQEMQLLQVAamNYRLRPLEKFVTYFTR--MEQL-SDK 80
Cdd:smart00147 152 LPPCIPFLGVLLKDLTFIDEGNPDFLENglvNFEKRRQIAEILREIRQLQSQ--PYNLRPNRSDIQSLLQqlLDHLdEEE 229

                           90
                   ....*....|.
gi 1043261390   81 ESYKLSCQLEP 91
Cdd:smart00147 230 ELYQLSLKIEP 240
 
Name Accession Description Interval E-value
RasGEF cd00155
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of ...
 5-88 4.72e-13

Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. Guanine-nucleotide-exchange factors (GEFs) positively regulate these GTP-binding proteins in response to a variety of signals. GEFs catalyze the dissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors.


Pssm-ID: 238087 [Multi-domain]  Cd Length: 237  Bit Score: 61.88  E-value: 4.72e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043261390   5 RQKKGVVPFLGDFLTELQRLDSAIPDDLDGNT---NKRSKEVRVLQEMQLLQVAamNYRLRPLEKFVTYFT--RMEQLSD 79
Cdd:cd00155   151 GPNPPCVPFLGVYLKDLTFLHEGNPDFLEGNLvnfEKRRKIAEILREIRQLQSN--SYELNRDEDILAFLWklLELILNE 228


                  ....*....
gi 1043261390  80 KESYKLSCQ 88
Cdd:cd00155   229 DELYELSLE 237
RasGEF smart00147
Guanine nucleotide exchange factor for Ras-like small GTPases;
7-91 9.81e-12

Guanine nucleotide exchange factor for Ras-like small GTPases;


Pssm-ID: 214539  Cd Length: 242  Bit Score: 58.41  E-value: 9.81e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043261390    7 KKGVVPFLGDFLTELQRLDSAIPDDLDG---NTNKRSKEVRVLQEMQLLQVAamNYRLRPLEKFVTYFTR--MEQL-SDK 80
Cdd:smart00147 152 LPPCIPFLGVLLKDLTFIDEGNPDFLENglvNFEKRRQIAEILREIRQLQSQ--PYNLRPNRSDIQSLLQqlLDHLdEEE 229

                           90
                   ....*....|.
gi 1043261390   81 ESYKLSCQLEP 91
Cdd:smart00147 230 ELYQLSLKIEP 240
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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