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Conserved domains on  [gi|1045961242|ref|NP_001316596|]
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galanin peptides isoform 2 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Galanin super family cl30967
Galanin; Galanin is a neuropeptide that controls various biological activities: it regulates ...
 21-108 6.36e-54

Galanin; Galanin is a neuropeptide that controls various biological activities: it regulates the release growth hormone, inhibits the release of insulin and somatostatin, contracts smooth muscle of the gastrointestinal and genitourinary tract and may be involved in the control of adrenal secretion


The actual alignment was detected with superfamily member smart00071:

Pssm-ID: 128385 [Multi-domain]  Cd Length: 103  Bit Score: 165.05  E-value: 6.36e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045961242   21 TLGLGMPAKEKRGWTLNSAGYLLGPHAIDNHRSFSDKHGLTGKRELQLEVeERRPGSVDVPLPESNIVRTIMEFLSFLHL 100
Cdd:smart00071   1 TLGLGSPVKEKRGWTLNSAGYLLGPHAIDNHRSFHDKHGLTGKRELEPED-EARPGSFDRPLSESNIVRTIIEFLTFLHL 79

                           90
                   ....*....|
gi 1045961242  101 KGRG--PRQP 108
Cdd:smart00071  80 KEAGalDRLP 89
 
Name Accession Description Interval E-value
Galanin smart00071
Galanin; Galanin is a neuropeptide that controls various biological activities: it regulates ...
 21-108 6.36e-54

Galanin; Galanin is a neuropeptide that controls various biological activities: it regulates the release growth hormone, inhibits the release of insulin and somatostatin, contracts smooth muscle of the gastrointestinal and genitourinary tract and may be involved in the control of adrenal secretion


Pssm-ID: 128385 [Multi-domain]  Cd Length: 103  Bit Score: 165.05  E-value: 6.36e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045961242   21 TLGLGMPAKEKRGWTLNSAGYLLGPHAIDNHRSFSDKHGLTGKRELQLEVeERRPGSVDVPLPESNIVRTIMEFLSFLHL 100
Cdd:smart00071   1 TLGLGSPVKEKRGWTLNSAGYLLGPHAIDNHRSFHDKHGLTGKRELEPED-EARPGSFDRPLSESNIVRTIIEFLTFLHL 79

                           90
                   ....*....|
gi 1045961242  101 KGRG--PRQP 108
Cdd:smart00071  80 KEAGalDRLP 89
GMAP pfam06540
Galanin message associated peptide (GMAP); This family consists of several galanin message ...
 62-104 4.78e-21

Galanin message associated peptide (GMAP); This family consists of several galanin message associated peptides. In rat preprogalanin, galanin is C-terminally flanked by a 60 amino acid long peptide: galanin message-associated peptide (GMAP). GMAP sequences in different species show high degree of homology, but the biological function of this family is unknown.


Pssm-ID: 461941  Cd Length: 61  Bit Score: 80.18  E-value: 4.78e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1045961242  62 GKRELQLEvEERRPGSVDVPLPESNIVRTIMEFLSFLHLKGRG 104
Cdd:pfam06540   1 GKRELQPE-DEAKPGSFDRPLPENNIVRTIIEFLTFLHLKEAG 42
 
Name Accession Description Interval E-value
Galanin smart00071
Galanin; Galanin is a neuropeptide that controls various biological activities: it regulates ...
 21-108 6.36e-54

Galanin; Galanin is a neuropeptide that controls various biological activities: it regulates the release growth hormone, inhibits the release of insulin and somatostatin, contracts smooth muscle of the gastrointestinal and genitourinary tract and may be involved in the control of adrenal secretion


Pssm-ID: 128385 [Multi-domain]  Cd Length: 103  Bit Score: 165.05  E-value: 6.36e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045961242   21 TLGLGMPAKEKRGWTLNSAGYLLGPHAIDNHRSFSDKHGLTGKRELQLEVeERRPGSVDVPLPESNIVRTIMEFLSFLHL 100
Cdd:smart00071   1 TLGLGSPVKEKRGWTLNSAGYLLGPHAIDNHRSFHDKHGLTGKRELEPED-EARPGSFDRPLSESNIVRTIIEFLTFLHL 79

                           90
                   ....*....|
gi 1045961242  101 KGRG--PRQP 108
Cdd:smart00071  80 KEAGalDRLP 89
GMAP pfam06540
Galanin message associated peptide (GMAP); This family consists of several galanin message ...
 62-104 4.78e-21

Galanin message associated peptide (GMAP); This family consists of several galanin message associated peptides. In rat preprogalanin, galanin is C-terminally flanked by a 60 amino acid long peptide: galanin message-associated peptide (GMAP). GMAP sequences in different species show high degree of homology, but the biological function of this family is unknown.


Pssm-ID: 461941  Cd Length: 61  Bit Score: 80.18  E-value: 4.78e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1045961242  62 GKRELQLEvEERRPGSVDVPLPESNIVRTIMEFLSFLHLKGRG 104
Cdd:pfam06540   1 GKRELQPE-DEAKPGSFDRPLPENNIVRTIIEFLTFLHLKEAG 42
Galanin pfam01296
Galanin;
33-60 4.30e-14

Galanin;


Pssm-ID: 366564  Cd Length: 29  Bit Score: 61.87  E-value: 4.30e-14
                          10        20
                  ....*....|....*....|....*...
gi 1045961242  33 GWTLNSAGYLLGPHAIDNHRSFSDKHGL 60
Cdd:pfam01296   1 GWTLNSAGYLLGPHAIDGHRSFGDKHGL 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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