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Conserved domains on  [gi|1061385181|ref|NP_001317871|]
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LOW QUALITY PROTEIN: Cadherin-4 [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 724-822 3.44e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 3.44e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  724 SYYLRISENEKPGKDIFKVTANDFDGGNNGKIKFSLGNNQEkSSVISIDAKTGIVKLLKSLDREDQDVHTFAIIASDEGF 803
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1061385181  804 PMRVSVTNLTISVEDVNDN 822
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1674-1779 4.65e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.78  E-value: 4.65e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1674 VYRGTIRENMPTGSSVLsksllplVVSAIDEDPGSNGLVGYRMLSPKDEQMFSVDQYSGAIRTQMSFDFEKMKEYSFYVQ 1753
Cdd:cd11304      1 SYEVSVPENAPPGTVVL-------TVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVT 73

                           90       100
                   ....*....|....*....|....*.
gi 1061385181 1754 AFDMGQPPRRSlmPSLIVVTVIDEND 1779
Cdd:cd11304     74 ATDGGGPPLSS--TATVTITVLDVND 97
LamG smart00282
Laminin G domain;
3781-3907 5.02e-26

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 105.88  E-value: 5.02e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  3781 ELEIELKTTTHNGIIMW--SRGKRDFHMLRLVNGTPEYHWNAGTGTGIVTSKTSVV-DGQWHRIAISRRQRRTRMTVDDE 3857
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLnDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 1061385181  3858 DLQEAFSPIGSTVINLHrysQKLVLGAKVDDGEL-----TDGVSACFRTISVDGM 3907
Cdd:smart00282   81 NRVSGESPGGLTILNLD---GPLYLGGLPEDLKLpplpvTPGFRGCIRNLKVNGK 132
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2718-2808 1.29e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.55  E-value: 1.29e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2718 RFTISEDAAVGTSVTIFSAMDRDDSPSGRIRFSLVEENP--YFDLNENSGWLTVASQLDREKIDHYKLIARATDEGG--F 2793
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGppL 82

                           90
                   ....*....|....*
gi 1061385181 2794 NTDLPFTIVVSDVND 2808
Cdd:cd11304     83 SSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3221-3322 3.72e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 3.72e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3221 YVGKVKENSKSGEKVLTVKALDVDSEHFGAVSYELeivsetTTDTPVLPFAINSN-GDVLISQSIDYEKIKKYNLKVIAK 3299
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI------VSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|...
gi 1061385181 3300 DGGRPPLRSEALLEIHVEDENDH 3322
Cdd:cd11304     76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3117-3212 8.76e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.54  E-value: 8.76e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3117 TYSMKVMESESIGYELAHFRASGGDQ--NETIEYYLKPSDVTSFVNLNAQTGILTLAKPLDFETLSALKLTVVAKDSGVP 3194
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSgeNGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1061385181 3195 PLETEAQVEISVMDENDN 3212
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2510-2598 5.78e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 5.78e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2510 YSTSISESAKEGDTVMMVSATDDDE--NDTIEYSLLDGSESQFFSVHPRQGTITVAKKLEHKAGVTLSLTIKATDSANPP 2587
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSgeNGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|.
gi 1061385181 2588 HHATTTVEVNI 2598
Cdd:cd11304     82 LSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1473-1562 7.91e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.07  E-value: 7.91e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1473 FAFVDESDTVDDVLATVTAFDKDRGENGIVTYSIVSGNEESLFKIDAKSGEVRLAKPLDPELQHvESILRIRAIDSAANS 1552
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQS-SYTLTVTATDGGGPP 81

                           90
                   ....*....|
gi 1061385181 1553 LKDEMSLHIR 1562
Cdd:cd11304     82 LSSTATVTIT 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 940-1042 2.62e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 2.62e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  940 EASVYENSEIGTEVIMIEAKetgDEQKVKAENLEYRIIGGDGWPHFSIDQK-GTVRTTHLLDRETKSAYWITVEARDSKT 1018
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSAT---DPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90       100
                   ....*....|....*....|....
gi 1061385181 1019 dlykdPRRRDVLHVFIRILDRNDH 1042
Cdd:cd11304     80 -----PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1051-1152 3.18e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.14  E-value: 3.18e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1051 YIASVAENSPANVVIVKVEATDADDVDNDaaaPLMFKIERGDPQSFFRIDLTSGYITTsgIRRLDREKQSEHELWVSICD 1130
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENG---EVTYSIVSGNEDGLFSIDPSTGEITT--AKPLDREEQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|..
gi 1061385181 1131 GGEPQLCSNVIVIVNVLDENDN 1152
Cdd:cd11304     77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 615-716 7.85e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.98  E-value: 7.85e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  615 VEVTEDAPIGTVVAKLQANDEDTGYNGFIRYVIHDiaGSSHEVLTVDEQSGEITVAsdlSKLMKEKLEVLdvQLKVSAID 694
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS--GNEDGLFSIDPSTGEITTA---KPLDREEQSSY--TLTVTATD 76

                           90       100
                   ....*....|....*....|..
gi 1061385181  695 AGTPVKSSVKTMKLRIKDVNNH 716
Cdd:cd11304     77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2191-2280 1.34e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.60  E-value: 1.34e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2191 YTASTPESTSIGQRLLTIKATTSDE--NDTIEYSLSGSKDIE---IHPETGDVTITGQLDYEKTQKYDLKLVATSSGK-Q 2264
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSgeNGEVTYSIVSGNEDGlfsIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpP 81

                           90
                   ....*....|....*.
gi 1061385181 2265 VSSEAEFIVLIEDVND 2280
Cdd:cd11304     82 LSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3018-3109 1.65e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.52  E-value: 1.65e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3018 VSIDENLPtsedARQYITRIVAEDAD---FDEIKFRMV-DDFGGLFQIDDINGVVTVVKPLDSEILGFFNLTVVASDGE- 3092
Cdd:cd11304      4 VSVPENAP----PGTVVLTVSATDPDsgeNGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGg 79

                           90
                   ....*....|....*....
gi 1061385181 3093 --FEDKATILVTVIDQNDN 3109
Cdd:cd11304     80 ppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2612-2708 3.43e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 79.66  E-value: 3.43e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2612 HYLFSVMEDADVGNVIGRVQQM---ETEIDEIRFTIVPGSEESdsflPFSVERSTGKIIVKSSLDRERKNQWKMTIRA-D 2687
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSGNEDG----LFSIDPSTGEITTAKPLDREEQSSYTLTVTAtD 76

                           90       100
                   ....*....|....*....|..
gi 1061385181 2688 AAGGVH-AITTVTVDIGDVNDN 2708
Cdd:cd11304     77 GGGPPLsSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 832-925 4.46e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 79.28  E-value: 4.46e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  832 RARIPEDLPHGAFVSCMAAFDEDIGQNSKLKFLL--NSEKVPFRIDHHSGCIFIHAPeypLDYHKTPFFNLSIEVADHGD 909
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKP---LDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*.
gi 1061385181  910 PILSTSCHLHVELVDI 925
Cdd:cd11304     80 PPLSSTATVTITVLDV 95
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1887-1979 8.25e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.26  E-value: 8.25e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1887 EYHTSLIENTtlPPGSIILSV-ATIGDKLD----HFSIV--NPHEAFFIHPGTGVISSSGiALDREKSAIIRLVVQAKSH 1959
Cdd:cd11304      1 SYEVSVPENA--PPGTVVLTVsATDPDSGEngevTYSIVsgNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|
gi 1061385181 1960 EKNPVMARALVVVGIENIND 1979
Cdd:cd11304     78 GGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 160-254 9.45e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.26  E-value: 9.45e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  160 YEAEIDDDLEPFSTVLRVEASDADIGINSAIYFSLV--NRSHDFIVEPVTGWV---RSLRHVKPGKYSLKVKSEDRASRl 234
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEIttaKPLDREEQSSYTLTVTATDGGGP- 80

                           90       100
                   ....*....|....*....|
gi 1061385181  235 yyfdenevQPSWTADVLITV 254
Cdd:cd11304     81 --------PLSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1367-1463 1.49e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 63.49  E-value: 1.49e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1367 HYQTDVSERVAVGTQIYTLKASGESLGTKPLVFnlFSVDDVAMEDKIRVEPSSGNVIVMEPLDYEAARRIRAVVQVQ--- 1443
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVT--YSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATdgg 78

                           90       100
                   ....*....|....*....|
gi 1061385181 1444 QANMKSFATFSVNINDENDN 1463
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1269-1353 4.43e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.25  E-value: 4.43e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1269 YVIPISDADQVGLTVGKLEASDADGDELWW---SISSGDPDSVFDVRQDTGQLLLAKKVELLKRGELRLNISVTDG---Q 1342
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEvtySIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggpP 81

                           90
                   ....*....|.
gi 1061385181 1343 AWDHSTVIIQV 1353
Cdd:cd11304     82 LSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1175-1235 7.14e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.86  E-value: 7.14e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1061385181 1175 RIFAVDADEGENARLTYNITEGDAR--FSID-NNGNIIASEAIhgD----ESYALTVQATDHGTPGQQ 1235
Cdd:cd11304     18 TVSATDPDSGENGEVTYSIVSGNEDglFSIDpSTGEITTAKPL--DreeqSSYTLTVTATDGGGPPLS 83
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 416-490 1.30e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.36  E-value: 1.30e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1061385181   416 SLIRYSLEYSksdlpNATLPFAIGSKNGILRVSAKINRSER-VYNFKVIASLHGINEKLAEKDVSIEILDSNDHAP 490
Cdd:smart00112   11 GKVTYSILSG-----NDDGLFSIDPETGEITTTKPLDREEQpEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3332-3418 2.21e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 57.32  E-value: 2.21e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3332 TALVQEGEAIGHRLLKFSVSDLDGPKNGaPFTVEIQGDGAKS-FKVNEKL-ELLTAKKLEYRKKDKYLLTVIAKD--VKG 3407
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDGlFSIDPSTgEITTAKPLDREEQSSYTLTVTATDggGPP 81

                           90
                   ....*....|.
gi 1061385181 3408 KTTDCPLTIFI 3418
Cdd:cd11304     82 LSSTATVTITV 92
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3968-4004 1.25e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 53.41  E-value: 1.25e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1061385181 3968 DLEPCAS-SPCPTGIQCIPFYNDYLCKCPNGFTGKHCE 4004
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2291-2386 1.60e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.01  E-value: 1.60e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2291 SAKISDSAITGQFITIMSATDMDttnslDEESQKLLYKIVDGDET-LFNISPATGELSLARPV--EQDDLVNedtkkvLN 2367
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPD-----SGENGEVTYSIVSGNEDgLFSIDPSTGEITTAKPLdrEEQSSYT------LT 71

                           90       100
                   ....*....|....*....|..
gi 1061385181 2368 VSVTDG---MFTAYAKLVVEIL 2386
Cdd:cd11304     72 VTATDGggpPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3440-3536 1.81e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 54.63  E-value: 1.81e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3440 NELPEGIIGRLKASDEDEeDQNGLLRFGLVEGSiqspraqvqesrSTHLFRVDPNTGDIWSDHSI---TQGLHTFNVTVT 3516
Cdd:cd11304      9 NAPPGTVVLTVSATDPDS-GENGEVTYSIVSGN------------EDGLFSIDPSTGEITTAKPLdreEQSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|...
gi 1061385181 3517 DS---KFNTVSYVEVHVTSIdND 3536
Cdd:cd11304     76 DGggpPLSSTATVTITVLDV-ND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2817-2903 7.09e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 53.09  E-value: 7.09e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2817 EFNIDLHLPSTSPILHFSIKDDDLSPNNVSQFFIPKGNEEGVFWIDSNN-DLLLKRPEIVENKMQYQLKVTAFDG---VF 2892
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTgEITTAKPLDREEQSSYTLTVTATDGggpPL 82

                           90
                   ....*....|.
gi 1061385181 2893 ETSTKVKINLK 2903
Cdd:cd11304     83 SSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2449-2503 5.61e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.04  E-value: 5.61e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1061385181  2449 PVAIDRKTGRIHVSRVLNYHRDKRYQIPLVVEDATG--RRAFSTLTLSVIDINDKPP 2503
Cdd:smart00112   25 LFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 506-570 7.07e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 50.39  E-value: 7.07e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  506 KPGDVLVKVDATDQDEGENGKIVYKFTS---ELPLEINANTGEITLVEV--PKKGNSWPATVWAIDLGLP 570
Cdd:cd11304     11 PPGTVVLTVSATDPDSGENGEVTYSIVSgneDGLFSIDPSTGEITTAKPldREEQSSYTLTVTATDGGGP 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2085-2176 8.11e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 50.00  E-value: 8.11e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2085 VYTAVISkESTKKSTVLVKVMAkSSLQSKSKGLIGYRIL--DKKSPFSVDFLTGEVRLNN-LKMLAETNYTFEVEAREVT 2161
Cdd:cd11304      1 SYEVSVP-ENAPPGTVVLTVSA-TDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKpLDREEQSSYTLTVTATDGG 78

                           90
                   ....*....|....*
gi 1061385181 2162 RPKMIAKAQVEIIVK 2176
Cdd:cd11304     79 GPPLSSTATVTITVL 93
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 3933-3963 2.46e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 46.61  E-value: 2.46e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1061385181 3933 CNDLPCQHAGTCIsQGKSHFKCECPSRYSGN 3963
Cdd:pfam00008    1 CAPNPCSNGGTCV-DTPGGYTCICPEGYTGK 30
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1988-2075 9.05e-04

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 41.53  E-value: 9.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1988 PYDITIG-HSDIGTVVLEPKVIDNDEGD----VVTISSENMPEYFKI--VGGKVVLGKKLPSieEEDLEFNFKLIAKDNG 2060
Cdd:cd11304      1 SYEVSVPeNAPPGTVVLTVSATDPDSGEngevTYSIVSGNEDGLFSIdpSTGEITTAKPLDR--EEQSSYTLTVTATDGG 78

                           90
                   ....*....|....*.
gi 1061385181 2061 SVHRVEE-PVKIRVVD 2075
Cdd:cd11304     79 GPPLSSTaTVTITVLD 94
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2941-3009 1.01e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member smart00112:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 81  Bit Score: 40.80  E-value: 1.01e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1061385181  2941 NVTFKL-SDNDGNVFVVNFRNGIVKVKEsdQIDYEKNQQLEFhRLTIQDNSEVCKE---LITVVIENLNDNRP 3009
Cdd:smart00112   12 KVTYSIlSGNDDGLFSIDPETGEITTTK--PLDREEQPEYTL-TVEATDGGGPPLSstaTVTITVLDVNDNAP 81
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 3710-3749 9.84e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


:

Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 9.84e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1061385181 3710 CAKS-PCEQWQLCIPSVhnSTYECVCPLGMEGDKcsvpSCQ 3749
Cdd:cd00053      2 CAASnPCSNGGTCVNTP--GSYRCVCPPGYTGDR----SCE 36
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 724-822 3.44e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 3.44e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  724 SYYLRISENEKPGKDIFKVTANDFDGGNNGKIKFSLGNNQEkSSVISIDAKTGIVKLLKSLDREDQDVHTFAIIASDEGF 803
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1061385181  804 PMRVSVTNLTISVEDVNDN 822
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1674-1779 4.65e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.78  E-value: 4.65e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1674 VYRGTIRENMPTGSSVLsksllplVVSAIDEDPGSNGLVGYRMLSPKDEQMFSVDQYSGAIRTQMSFDFEKMKEYSFYVQ 1753
Cdd:cd11304      1 SYEVSVPENAPPGTVVL-------TVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVT 73

                           90       100
                   ....*....|....*....|....*.
gi 1061385181 1754 AFDMGQPPRRSlmPSLIVVTVIDEND 1779
Cdd:cd11304     74 ATDGGGPPLSS--TATVTITVLDVND 97
LamG smart00282
Laminin G domain;
3781-3907 5.02e-26

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 105.88  E-value: 5.02e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  3781 ELEIELKTTTHNGIIMW--SRGKRDFHMLRLVNGTPEYHWNAGTGTGIVTSKTSVV-DGQWHRIAISRRQRRTRMTVDDE 3857
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLnDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 1061385181  3858 DLQEAFSPIGSTVINLHrysQKLVLGAKVDDGEL-----TDGVSACFRTISVDGM 3907
Cdd:smart00282   81 NRVSGESPGGLTILNLD---GPLYLGGLPEDLKLpplpvTPGFRGCIRNLKVNGK 132
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2718-2808 1.29e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.55  E-value: 1.29e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2718 RFTISEDAAVGTSVTIFSAMDRDDSPSGRIRFSLVEENP--YFDLNENSGWLTVASQLDREKIDHYKLIARATDEGG--F 2793
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGppL 82

                           90
                   ....*....|....*
gi 1061385181 2794 NTDLPFTIVVSDVND 2808
Cdd:cd11304     83 SSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3221-3322 3.72e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 3.72e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3221 YVGKVKENSKSGEKVLTVKALDVDSEHFGAVSYELeivsetTTDTPVLPFAINSN-GDVLISQSIDYEKIKKYNLKVIAK 3299
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI------VSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|...
gi 1061385181 3300 DGGRPPLRSEALLEIHVEDENDH 3322
Cdd:cd11304     76 DGGGPPLSSTATVTITVLDVNDN 98
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 3760-3905 2.32e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 102.11  E-value: 2.32e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3760 LSVGGDGYFEISLSNEIETRMELEIELKTTTHNGIIMW--SRGKRDFHMLRLVNGTPEYHWNAGTGTGIVTSKTSVVDGQ 3837
Cdd:cd00110      2 VSFSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYagSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQ 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1061385181 3838 WHRIAISRRQRRTRMTVDDEDLQEAFSPIGSTVINLHrysQKLVLGAKVDDGEL-----TDGVSACFRTISVD 3905
Cdd:cd00110     82 WHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLD---GPLYLGGLPEDLKSpglpvSPGFVGCIRDLKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3117-3212 8.76e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.54  E-value: 8.76e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3117 TYSMKVMESESIGYELAHFRASGGDQ--NETIEYYLKPSDVTSFVNLNAQTGILTLAKPLDFETLSALKLTVVAKDSGVP 3194
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSgeNGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1061385181 3195 PLETEAQVEISVMDENDN 3212
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2510-2598 5.78e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 5.78e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2510 YSTSISESAKEGDTVMMVSATDDDE--NDTIEYSLLDGSESQFFSVHPRQGTITVAKKLEHKAGVTLSLTIKATDSANPP 2587
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSgeNGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|.
gi 1061385181 2588 HHATTTVEVNI 2598
Cdd:cd11304     82 LSSTATVTITV 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 743-824 9.07e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.03  E-value: 9.07e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181   743 TANDFDGGNNGKIKFSLgNNQEKSSVISIDAKTGIVKLLKSLDREDQDVHTFAIIASDEGFPMRVSVTNLTISVEDVNDN 822
Cdd:smart00112    1 SATDADSGENGKVTYSI-LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1061385181   823 PP 824
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1700-1782 3.15e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.49  E-value: 3.15e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  1700 SAIDEDPGSNGLVGYRMLSPKDEQMFSVDQYSGAIRTQMSFDFEKMKEYSFYVQAFDMGQPPRRSlmPSLIVVTVIDEND 1779
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSS--TATVTITVLDVND 78


                    ...
gi 1061385181  1780 EPP 1782
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1473-1562 7.91e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.07  E-value: 7.91e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1473 FAFVDESDTVDDVLATVTAFDKDRGENGIVTYSIVSGNEESLFKIDAKSGEVRLAKPLDPELQHvESILRIRAIDSAANS 1552
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQS-SYTLTVTATDGGGPP 81

                           90
                   ....*....|
gi 1061385181 1553 LKDEMSLHIR 1562
Cdd:cd11304     82 LSSTATVTIT 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 940-1042 2.62e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 2.62e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  940 EASVYENSEIGTEVIMIEAKetgDEQKVKAENLEYRIIGGDGWPHFSIDQK-GTVRTTHLLDRETKSAYWITVEARDSKT 1018
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSAT---DPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90       100
                   ....*....|....*....|....
gi 1061385181 1019 dlykdPRRRDVLHVFIRILDRNDH 1042
Cdd:cd11304     80 -----PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1051-1152 3.18e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.14  E-value: 3.18e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1051 YIASVAENSPANVVIVKVEATDADDVDNDaaaPLMFKIERGDPQSFFRIDLTSGYITTsgIRRLDREKQSEHELWVSICD 1130
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENG---EVTYSIVSGNEDGLFSIDPSTGEITT--AKPLDREEQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|..
gi 1061385181 1131 GGEPQLCSNVIVIVNVLDENDN 1152
Cdd:cd11304     77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 615-716 7.85e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.98  E-value: 7.85e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  615 VEVTEDAPIGTVVAKLQANDEDTGYNGFIRYVIHDiaGSSHEVLTVDEQSGEITVAsdlSKLMKEKLEVLdvQLKVSAID 694
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS--GNEDGLFSIDPSTGEITTA---KPLDREEQSSY--TLTVTATD 76

                           90       100
                   ....*....|....*....|..
gi 1061385181  695 AGTPVKSSVKTMKLRIKDVNNH 716
Cdd:cd11304     77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2191-2280 1.34e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.60  E-value: 1.34e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2191 YTASTPESTSIGQRLLTIKATTSDE--NDTIEYSLSGSKDIE---IHPETGDVTITGQLDYEKTQKYDLKLVATSSGK-Q 2264
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSgeNGEVTYSIVSGNEDGlfsIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpP 81

                           90
                   ....*....|....*.
gi 1061385181 2265 VSSEAEFIVLIEDVND 2280
Cdd:cd11304     82 LSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
2719-2804 2.35e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.43  E-value: 2.35e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2719 FTISEDAAVGTSVTIFSAMDRDDSPSGRIRFSLVEENPY--FDLNENSGWLTVASQLDREKIDHYKLIARATDEGGFNTD 2796
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82


                   ....*...
gi 1061385181 2797 LPFTIVVS 2804
Cdd:pfam00028   83 STATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2735-2811 8.84e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.55  E-value: 8.84e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  2735 SAMDRDDSPSGRIRFSLVEENP--YFDLNENSGWLTVASQLDREKIDHYKLIARATDEGGFN--TDLPFTIVVSDVNDSP 2810
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDdgLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPlsSTATVTITVLDVNDNA 80


                    .
gi 1061385181  2811 P 2811
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3141-3214 1.06e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.17  E-value: 1.06e-18
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1061385181  3141 DQNETIEYYLKPSDVTSFVNLNAQTGILTLAKPLDFETLSALKLTVVAKDSGVPPLETEAQVEISVMDENDNAP 3214
Cdd:smart00112    8 GENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3018-3109 1.65e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.52  E-value: 1.65e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3018 VSIDENLPtsedARQYITRIVAEDAD---FDEIKFRMV-DDFGGLFQIDDINGVVTVVKPLDSEILGFFNLTVVASDGE- 3092
Cdd:cd11304      4 VSVPENAP----PGTVVLTVSATDPDsgeNGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGg 79

                           90
                   ....*....|....*....
gi 1061385181 3093 --FEDKATILVTVIDQNDN 3109
Cdd:cd11304     80 ppLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1675-1775 3.01e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.35  E-value: 3.01e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1675 YRGTIRENMPTGSSVLSksllplvVSAIDEDPGSNGLVGYRMLSPKDEQMFSVDQYSGAIRTQMSFDFEKMKEYSFYVQA 1754
Cdd:pfam00028    1 YSASVPENAPVGTEVLT-------VTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA 73

                           90       100
                   ....*....|....*....|.
gi 1061385181 1755 FDMGQPPRRSlmPSLIVVTVI 1775
Cdd:pfam00028   74 TDSGGPPLSS--TATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3239-3324 7.32e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.86  E-value: 7.32e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  3239 KALDVDSEHFGAVSYELeivsetTTDTPVLPFAINSN-GDVLISQSIDYEKIKKYNLKVIAKDGGRPPLRSEALLEIHVE 3317
Cdd:smart00112    1 SATDADSGENGKVTYSI------LSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                    ....*..
gi 1061385181  3318 DENDHAP 3324
Cdd:smart00112   75 DVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1084-1154 3.06e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.93  E-value: 3.06e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1061385181  1084 LMFKIERGDPQSFFRIDLTSGYITTSgiRRLDREKQSEHELWVSICDGGEPQLCSNVIVIVNVLDENDNSP 1154
Cdd:smart00112   13 VTYSILSGNDDGLFSIDPETGEITTT--KPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2612-2708 3.43e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 79.66  E-value: 3.43e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2612 HYLFSVMEDADVGNVIGRVQQM---ETEIDEIRFTIVPGSEESdsflPFSVERSTGKIIVKSSLDRERKNQWKMTIRA-D 2687
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSGNEDG----LFSIDPSTGEITTAKPLDREEQSSYTLTVTAtD 76

                           90       100
                   ....*....|....*....|..
gi 1061385181 2688 AAGGVH-AITTVTVDIGDVNDN 2708
Cdd:cd11304     77 GGGPPLsSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 832-925 4.46e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 79.28  E-value: 4.46e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  832 RARIPEDLPHGAFVSCMAAFDEDIGQNSKLKFLL--NSEKVPFRIDHHSGCIFIHAPeypLDYHKTPFFNLSIEVADHGD 909
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKP---LDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*.
gi 1061385181  910 PILSTSCHLHVELVDI 925
Cdd:cd11304     80 PPLSSTATVTITVLDV 95
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1490-1562 1.62e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.31  E-value: 1.62e-15
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1061385181  1490 TAFDKDRGENGIVTYSIVSGNEESLFKIDAKSGEVRLAKPLDPELQHVESiLRIRAIDSAANSLKDEMSLHIR 1562
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYT-LTVEATDGGGPPLSSTATVTIT 72
Cadherin pfam00028
Cadherin domain;
725-817 1.65e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.64  E-value: 1.65e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  725 YYLRISENEKPGKDIFKVTANDFDGGNNGKIKFSLGNnQEKSSVISIDAKTGIVKLLKSLDREDQDVHTFAIIASDEGFP 804
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILG-GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1061385181  805 MRVSVTNLTISVE 817
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1474-1561 3.96e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.49  E-value: 3.96e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1474 AFVDESDTVDDVLATVTAFDKDRGENGIVTYSIVSGNEESLFKIDAKSGEVRLAKPLDPELQHvESILRIRAIDSAANSL 1553
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIG-EYELTVEATDSGGPPL 81


                   ....*...
gi 1061385181 1554 KDEMSLHI 1561
Cdd:pfam00028   82 SSTATVTI 89
Cadherin pfam00028
Cadherin domain;
3118-3206 1.19e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 1.19e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3118 YSMKVMESESIGYELAHFRASGGD--QNETIEYYLKPSDVTSFVNLNAQTGILTLAKPLDFETLSALKLTVVAKDSGVPP 3195
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDlgPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1061385181 3196 LETEAQVEISV 3206
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
2510-2598 1.25e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 1.25e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2510 YSTSISESAKEGDTVMMVSATDDDE--NDTIEYSLLDGSESQFFSVHPRQGTITVAKKLEHKAGVTLSLTIKATDSANPP 2587
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLgpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1061385181 2588 HHATTTVEVNI 2598
Cdd:pfam00028   81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3038-3111 1.35e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.61  E-value: 1.35e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  3038 VAEDADFDE---IKFRMVDDF-GGLFQIDDINGVVTVVKPLDSEILGFFNLTVVASDG---EFEDKATILVTVIDQNDNA 3110
Cdd:smart00112    1 SATDADSGEngkVTYSILSGNdDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVNDNA 80


                    .
gi 1061385181  3111 P 3111
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 971-1044 2.16e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.84  E-value: 2.16e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1061385181   971 NLEYRIIGGDGWPHFSIDQK-GTVRTTHLLDRETKSAYWITVEARDSKTdlykdPRRRDVLHVFIRILDRNDHRP 1044
Cdd:smart00112   12 KVTYSILSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGG-----PPLSSTATVTITVLDVNDNAP 81
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 3786-3906 2.73e-14

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 72.45  E-value: 2.73e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3786 LKTTTHNGIIMWSRGKR-DFHMLRLVNGTPEYHWNAGTGTGIVTSKTSVV-DGQWHRIAISRRQRRTRMTVDDEDLQEAF 3863
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGsDFLALELVNGRLVLRYDLGSGPESLLSSGKNLnDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1061385181 3864 SPIGSTVINLHRYsqkLVLGAKVDDGEL-----TDGVSACFRTISVDG 3906
Cdd:pfam02210   81 PPGESLLLNLNGP---LYLGGLPPLLLLpalpvRAGFVGCIRDVRVNG 125
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2528-2598 1.01e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 1.01e-13
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1061385181  2528 SATDDDE--NDTIEYSLLDGSESQFFSVHPRQGTITVAKKLEHKAGVTLSLTIKATDSANPPHHATTTVEVNI 2598
Cdd:smart00112    1 SATDADSgeNGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 850-925 1.61e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 1.61e-13
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1061385181   850 AFDEDIGQNSKLKFLLNS--EKVPFRIDHHSGCIFIHAPeypLDYHKTPFFNLSIEVADHGDPILSTSCHLHVELVDI 925
Cdd:smart00112    2 ATDADSGENGKVTYSILSgnDDGLFSIDPETGEITTTKP---LDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76
Cadherin pfam00028
Cadherin domain;
3221-3317 2.85e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.10  E-value: 2.85e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3221 YVGKVKENSKSGEKVLTVKALDVDSEHFGAVSYELeivsetTTDTPVLPFAIN-SNGDVLISQSIDYEKIKKYNLKVIAK 3299
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI------LGGGPGGNFRIDpDTGDISTTKPLDRESIGEYELTVEAT 74

                           90
                   ....*....|....*...
gi 1061385181 3300 DGGRPPLRSEALLEIHVE 3317
Cdd:pfam00028   75 DSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2639-2710 1.88e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.45  E-value: 1.88e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1061385181  2639 EIRFTIVPGSEESdsflPFSVERSTGKIIVKSSLDRERKNQWKMTIRADAAGGV--HAITTVTVDIGDVNDNAP 2710
Cdd:smart00112   12 KVTYSILSGNDDG----LFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPplSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
2191-2276 2.73e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.40  E-value: 2.73e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2191 YTASTPESTSIGQRLLTIKATTSDE--NDTIEYSLSG---SKDIEIHPETGDVTITGQLDYEKTQKYDLKLVATSSGKQ- 2264
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLgpNGRIFYSILGggpGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPp 80

                           90
                   ....*....|..
gi 1061385181 2265 VSSEAEFIVLIE 2276
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2213-2283 3.28e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.68  E-value: 3.28e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1061385181  2213 SDENDTIEYSLSGSKD---IEIHPETGDVTITGQLDYEKTQKYDLKLVATSSGKQV-SSEAEFIVLIEDVNDEMP 2283
Cdd:smart00112    7 SGENGKVTYSILSGNDdglFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPlSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1887-1979 8.25e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.26  E-value: 8.25e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1887 EYHTSLIENTtlPPGSIILSV-ATIGDKLD----HFSIV--NPHEAFFIHPGTGVISSSGiALDREKSAIIRLVVQAKSH 1959
Cdd:cd11304      1 SYEVSVPENA--PPGTVVLTVsATDPDSGEngevTYSIVsgNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|
gi 1061385181 1960 EKNPVMARALVVVGIENIND 1979
Cdd:cd11304     78 GGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 160-254 9.45e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.26  E-value: 9.45e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  160 YEAEIDDDLEPFSTVLRVEASDADIGINSAIYFSLV--NRSHDFIVEPVTGWV---RSLRHVKPGKYSLKVKSEDRASRl 234
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEIttaKPLDREEQSSYTLTVTATDGGGP- 80

                           90       100
                   ....*....|....*....|
gi 1061385181  235 yyfdenevQPSWTADVLITV 254
Cdd:cd11304     81 --------PLSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1367-1463 1.49e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 63.49  E-value: 1.49e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1367 HYQTDVSERVAVGTQIYTLKASGESLGTKPLVFnlFSVDDVAMEDKIRVEPSSGNVIVMEPLDYEAARRIRAVVQVQ--- 1443
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVT--YSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATdgg 78

                           90       100
                   ....*....|....*....|
gi 1061385181 1444 QANMKSFATFSVNINDENDN 1463
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
833-922 1.69e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 1.69e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  833 ARIPEDLPHGAFVSCMAAFDEDIGQNSKLKFLL--NSEKVPFRIDHHSGCIFIHAPeypLDYHKTPFFNLSIEVADHGDP 910
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIDPDTGDISTTKP---LDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|..
gi 1061385181  911 ILSTSCHLHVEL 922
Cdd:pfam00028   80 PLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 631-718 7.44e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.83  E-value: 7.44e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181   631 QANDEDTGYNGFIRYVIHDiaGSSHEVLTVDEQSGEITVASDLSKlmkEKLEVLdvQLKVSAIDAGTPVKSSVKTMKLRI 710
Cdd:smart00112    1 SATDADSGENGKVTYSILS--GNDDGLFSIDPETGEITTTKPLDR---EEQPEY--TLTVEATDGGGPPLSSTATVTITV 73


                    ....*...
gi 1061385181   711 KDVNNHSP 718
Cdd:smart00112   74 LDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
615-711 4.34e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.24  E-value: 4.34e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  615 VEVTEDAPIGTVVAKLQANDEDTGYNGFIRYVIhdIAGSSHEVLTVDEQSGEITVASDLSklmKEKLEvlDVQLKVSAID 694
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI--LGGGPGGNFRIDPDTGDISTTKPLD---RESIG--EYELTVEATD 75

                           90
                   ....*....|....*..
gi 1061385181  695 AGTPVKSSVKTmkLRIK 711
Cdd:pfam00028   76 SGGPPLSSTAT--VTIT 90
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1269-1353 4.43e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.25  E-value: 4.43e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1269 YVIPISDADQVGLTVGKLEASDADGDELWW---SISSGDPDSVFDVRQDTGQLLLAKKVELLKRGELRLNISVTDG---Q 1342
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEvtySIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggpP 81

                           90
                   ....*....|.
gi 1061385181 1343 AWDHSTVIIQV 1353
Cdd:cd11304     82 LSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1175-1235 7.14e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.86  E-value: 7.14e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1061385181 1175 RIFAVDADEGENARLTYNITEGDAR--FSID-NNGNIIASEAIhgD----ESYALTVQATDHGTPGQQ 1235
Cdd:cd11304     18 TVSATDPDSGENGEVTYSIVSGNEDglFSIDpSTGEITTAKPL--DreeqSSYTLTVTATDGGGPPLS 83
Cadherin pfam00028
Cadherin domain;
940-1037 1.04e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.08  E-value: 1.04e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  940 EASVYENSEIGTEVIMIEAKetgDEQKVKAENLEYRIIGGDGWPHFSIDQK-GTVRTTHLLDRETKSAYWITVEARDSKT 1018
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTAT---DPDLGPNGRIFYSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....*....
gi 1061385181 1019 dlykdPRRRDVLHVFIRIL 1037
Cdd:pfam00028   79 -----PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 416-490 1.30e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.36  E-value: 1.30e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1061385181   416 SLIRYSLEYSksdlpNATLPFAIGSKNGILRVSAKINRSER-VYNFKVIASLHGINEKLAEKDVSIEILDSNDHAP 490
Cdd:smart00112   11 GKVTYSILSG-----NDDGLFSIDPETGEITTTKPLDREEQpEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
3018-3104 1.77e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.31  E-value: 1.77e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3018 VSIDENLPTSedarQYITRIVAEDADFDE---IKFRMV-DDFGGLFQIDDINGVVTVVKPLDSEILGFFNLTVVASDGEF 3093
Cdd:pfam00028    3 ASVPENAPVG----TEVLTVTATDPDLGPngrIFYSILgGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 1061385181 3094 ---EDKATILVTVI 3104
Cdd:pfam00028   79 pplSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 394-488 1.97e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 57.32  E-value: 1.97e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  394 EMAPIGRILYRmnVNVENPDD--VSLIRYSLEYsksdlPNATLPFAIGSKNGILRVSAKINR-SERVYNFKVIASLHGIN 470
Cdd:cd11304      8 ENAPPGTVVLT--VSATDPDSgeNGEVTYSIVS-----GNEDGLFSIDPSTGEITTAKPLDReEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1061385181  471 EKLAEKDVSIEILDSNDH 488
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3332-3418 2.21e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 57.32  E-value: 2.21e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3332 TALVQEGEAIGHRLLKFSVSDLDGPKNGaPFTVEIQGDGAKS-FKVNEKL-ELLTAKKLEYRKKDKYLLTVIAKD--VKG 3407
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDGlFSIDPSTgEITTAKPLDREEQSSYTLTVTATDggGPP 81

                           90
                   ....*....|.
gi 1061385181 3408 KTTDCPLTIFI 3418
Cdd:cd11304     82 LSSTATVTITV 92
Cadherin pfam00028
Cadherin domain;
1051-1147 2.24e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.31  E-value: 2.24e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1051 YIASVAENSPANVVIVKVEATDADDVDNDAaapLMFKIERGDPQSFFRIDLTSGYITTsgIRRLDREKQSEHELWVSICD 1130
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGR---IFYSILGGGPGGNFRIDPDTGDIST--TKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*..
gi 1061385181 1131 GGEPQLCSNVIVIVNVL 1147
Cdd:pfam00028   76 SGGPPLSSTATVTITVL 92
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3968-4004 1.25e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 53.41  E-value: 1.25e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1061385181 3968 DLEPCAS-SPCPTGIQCIPFYNDYLCKCPNGFTGKHCE 4004
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2291-2386 1.60e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.01  E-value: 1.60e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2291 SAKISDSAITGQFITIMSATDMDttnslDEESQKLLYKIVDGDET-LFNISPATGELSLARPV--EQDDLVNedtkkvLN 2367
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPD-----SGENGEVTYSIVSGNEDgLFSIDPSTGEITTAKPLdrEEQSSYT------LT 71

                           90       100
                   ....*....|....*....|..
gi 1061385181 2368 VSVTDG---MFTAYAKLVVEIL 2386
Cdd:cd11304     72 VTATDGggpPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3440-3536 1.81e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 54.63  E-value: 1.81e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3440 NELPEGIIGRLKASDEDEeDQNGLLRFGLVEGSiqspraqvqesrSTHLFRVDPNTGDIWSDHSI---TQGLHTFNVTVT 3516
Cdd:cd11304      9 NAPPGTVVLTVSATDPDS-GENGEVTYSIVSGN------------EDGLFSIDPSTGEITTAKPLdreEQSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|...
gi 1061385181 3517 DS---KFNTVSYVEVHVTSIdND 3536
Cdd:cd11304     76 DGggpPLSSTATVTITVLDV-ND 97
Cadherin pfam00028
Cadherin domain;
2613-2702 5.27e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.07  E-value: 5.27e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2613 YLFSVMEDADVGNVIGRVQQmeTEIDE-----IRFTIVPGSEESdsflPFSVERSTGKIIVKSSLDRERKNQWKMTIRAD 2687
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTA--TDPDLgpngrIFYSILGGGPGG----NFRIDPDTGDISTTKPLDRESIGEYELTVEAT 74

                           90
                   ....*....|....*
gi 1061385181 2688 AAGGVHAITTVTVDI 2702
Cdd:pfam00028   75 DSGGPPLSSTATVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1916-1982 6.04e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 52.74  E-value: 6.04e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1061385181  1916 HFSIV--NPHEAFFIHPGTGVISSSGiALDREKSAIIRLVVQAKSHEKNPVMARALVVVGIENINDETP 1982
Cdd:smart00112   14 TYSILsgNDDGLFSIDPETGEITTTK-PLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2817-2903 7.09e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 53.09  E-value: 7.09e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2817 EFNIDLHLPSTSPILHFSIKDDDLSPNNVSQFFIPKGNEEGVFWIDSNN-DLLLKRPEIVENKMQYQLKVTAFDG---VF 2892
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTgEITTAKPLDREEQSSYTLTVTATDGggpPL 82

                           90
                   ....*....|.
gi 1061385181 2893 ETSTKVKINLK 2903
Cdd:cd11304     83 SSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
3332-3418 9.19e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 52.69  E-value: 9.19e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3332 TALVQEGEAIGHRLLKFSVSDLDGPKNGAPFTVEIQGDGAKSFKVNEK-LELLTAKKLEYRKKDKYLLTVIAKD--VKGK 3408
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDsgGPPL 81

                           90
                   ....*....|
gi 1061385181 3409 TTDCPLTIFI 3418
Cdd:pfam00028   82 SSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
1175-1234 1.51e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 1.51e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1061385181 1175 RIFAVDADEGENARLTYNITEGDAR--FSIDNNGNIIAS------EAIhgdESYALTVQATDHGTPGQ 1234
Cdd:pfam00028   17 TVTATDPDLGPNGRIFYSILGGGPGgnFRIDPDTGDISTtkpldrESI---GEYELTVEATDSGGPPL 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1178-1234 1.82e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.20  E-value: 1.82e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1061385181  1178 AVDADEGENARLTYNITEGDAR--FSID-NNGNIIASEAI--HGDESYALTVQATDHGTPGQ 1234
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDglFSIDpETGEITTTKPLdrEEQPEYTLTVEATDGGGPPL 63
Cadherin pfam00028
Cadherin domain;
160-233 3.82e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.76  E-value: 3.82e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1061385181  160 YEAEIDDDLEPFSTVLRVEASDADIGINSAIYFSLV--NRSHDFIVEPVTGWVRSLRHV---KPGKYSLKVKSEDRASR 233
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPLdreSIGEYELTVEATDSGGP 79
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2449-2503 5.61e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.04  E-value: 5.61e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1061385181  2449 PVAIDRKTGRIHVSRVLNYHRDKRYQIPLVVEDATG--RRAFSTLTLSVIDINDKPP 2503
Cdd:smart00112   25 LFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 506-570 7.07e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 50.39  E-value: 7.07e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  506 KPGDVLVKVDATDQDEGENGKIVYKFTS---ELPLEINANTGEITLVEV--PKKGNSWPATVWAIDLGLP 570
Cdd:cd11304     11 PPGTVVLTVSATDPDSGENGEVTYSIVSgneDGLFSIDPSTGEITTAKPldREEQSSYTLTVTATDGGGP 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2085-2176 8.11e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 50.00  E-value: 8.11e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2085 VYTAVISkESTKKSTVLVKVMAkSSLQSKSKGLIGYRIL--DKKSPFSVDFLTGEVRLNN-LKMLAETNYTFEVEAREVT 2161
Cdd:cd11304      1 SYEVSVP-ENAPPGTVVLTVSA-TDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKpLDREEQSSYTLTVTATDGG 78

                           90
                   ....*....|....*
gi 1061385181 2162 RPKMIAKAQVEIIVK 2176
Cdd:cd11304     79 GPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1402-1465 8.89e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.27  E-value: 8.89e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1061385181  1402 FSVDDVAMEDKIRVEPSSGNVIVMEPLDYEAARRIRAVVQVQ---QANMKSFATFSVNINDENDNSP 1465
Cdd:smart00112   15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATdggGPPLSSTATVTITVLDVNDNAP 81
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 3933-3963 2.46e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 46.61  E-value: 2.46e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1061385181 3933 CNDLPCQHAGTCIsQGKSHFKCECPSRYSGN 3963
Cdd:pfam00008    1 CAPNPCSNGGTCV-DTPGGYTCICPEGYTGK 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
3972-4004 2.74e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 2.74e-06
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1061385181  3972 CAS-SPCPTGIQCIPFYNDYLCKCPNGFT-GKHCE 4004
Cdd:smart00179    5 CASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 3972-4002 8.38e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 45.07  E-value: 8.38e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1061385181 3972 CASSPCPTGIQCIPFYNDYLCKCPNGFTGKH 4002
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2451-2500 1.48e-05

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 46.54  E-value: 1.48e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1061385181 2451 AIDRKTGRIHVSRVLNYHRDKRYQIPLVVEDATG--RRAFSTLTLSVIDIND 2500
Cdd:cd11304     46 SIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGppLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
1888-1975 1.51e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 46.14  E-value: 1.51e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1888 YHTSLIENTtlPPGSIILSV-ATIGDKLDH----FSIVNPHEA--FFIHPGTGVISSsGIALDREKSAIIRLVVQAKSHE 1960
Cdd:pfam00028    1 YSASVPENA--PVGTEVLTVtATDPDLGPNgrifYSILGGGPGgnFRIDPDTGDIST-TKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1061385181 1961 KNPVMARALVVVGIE 1975
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1269-1353 5.60e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 44.60  E-value: 5.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1269 YVIPISDADQVGLTVGKLEASDADGDELW---WSISSGDPDSVFDVRQDTGQLLLAKKVELLKRGELRLNISVTDGQAWD 1345
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGrifYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1061385181 1346 HS---TVIIQV 1353
Cdd:pfam00028   81 LSstaTVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3451-3541 1.21e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 43.49  E-value: 1.21e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  3451 KASDEDEeDQNGLLRFGLVEGSIQspraqvqesrstHLFRVDPNTGDIWSDHSI---TQGLHTFNVTVTDS---KFNTVS 3524
Cdd:smart00112    1 SATDADS-GENGKVTYSILSGNDD------------GLFSIDPETGEITTTKPLdreEQPEYTLTVEATDGggpPLSSTA 67

                            90
                    ....*....|....*..
gi 1061385181  3525 YVEVHVTsidnDVIDHA 3541
Cdd:smart00112   68 TVTITVL----DVNDNA 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3349-3426 1.75e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 42.72  E-value: 1.75e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  3349 SVSDLDGPKNGAPFTVEIQGDGAKSFKVNEKL-ELLTAKKLEYRKKDKYLLTVIAKD--VKGKTTDCPLTIFIRQTSRHA 3425
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETgEITTTKPLDREEQPEYTLTVEATDggGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1061385181  3426 P 3426
Cdd:smart00112   81 P 81
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3937-3966 2.26e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 2.26e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1061385181 3937 PCQHAGTCISQGKShFKCECPSRYSGNVCE 3966
Cdd:cd00054     10 PCQNGGTCVNTVGS-YRCSCPPGYTGRNCE 38
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 179-254 3.22e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.95  E-value: 3.22e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181   179 ASDADIGINSAIYFSLVNRSHD--FIVEPVTGWVRSLRHV---KPGKYSLKVKSEDRASRlyyfdenevQPSWTADVLIT 253
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDglFSIDPETGEITTTKPLdreEQPEYTLTVEATDGGGP---------PLSSTATVTIT 72


                    .
gi 1061385181   254 V 254
Cdd:smart00112   73 V 73
Cadherin pfam00028
Cadherin domain;
3440-3531 3.65e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 42.29  E-value: 3.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3440 NELPEGIIGRLKASDEDEEdQNGLLRFGLVEGSIQspraqvqesrstHLFRVDPNTGDIWSDHSI---TQGLHTFNVTVT 3516
Cdd:pfam00028    8 NAPVGTEVLTVTATDPDLG-PNGRIFYSILGGGPG------------GNFRIDPDTGDISTTKPLdreSIGEYELTVEAT 74

                           90
                   ....*....|....*.
gi 1061385181 3517 DS-KFNTVSYVEVHVT 3531
Cdd:pfam00028   75 DSgGPPLSSTATVTIT 90
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1988-2075 9.05e-04

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 41.53  E-value: 9.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1988 PYDITIG-HSDIGTVVLEPKVIDNDEGD----VVTISSENMPEYFKI--VGGKVVLGKKLPSieEEDLEFNFKLIAKDNG 2060
Cdd:cd11304      1 SYEVSVPeNAPPGTVVLTVSATDPDSGEngevTYSIVSGNEDGLFSIdpSTGEITTAKPLDR--EEQSSYTLTVTATDGG 78

                           90
                   ....*....|....*.
gi 1061385181 2061 SVHRVEE-PVKIRVVD 2075
Cdd:cd11304     79 GPPLSSTaTVTITVLD 94
Cadherin pfam00028
Cadherin domain;
2291-2386 9.41e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 41.13  E-value: 9.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2291 SAKISDSAITGQFITIMSATDMDTTnsldeESQKLLYKIVDGDET-LFNISPATGELSLARPV--EQDDLVNedtkkvLN 2367
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLG-----PNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLdrESIGEYE------LT 70

                           90       100
                   ....*....|....*....|...
gi 1061385181 2368 VSVTD----GMfTAYAKLVVEIL 2386
Cdd:pfam00028   71 VEATDsggpPL-SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2941-3009 1.01e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 40.80  E-value: 1.01e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1061385181  2941 NVTFKL-SDNDGNVFVVNFRNGIVKVKEsdQIDYEKNQQLEFhRLTIQDNSEVCKE---LITVVIENLNDNRP 3009
Cdd:smart00112   12 KVTYSIlSGNDDGLFSIDPETGEITTTK--PLDREEQPEYTL-TVEATDGGGPPLSstaTVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
507-570 3.77e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.59  E-value: 3.77e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1061385181  507 PGDVLVKVDATDQDEGENGKIVYKFTSELP---LEINANTGEITLVEV--PKKGNSWPATVWAIDLGLP 570
Cdd:pfam00028   11 VGTEVLTVTATDPDLGPNGRIFYSILGGGPggnFRIDPDTGDISTTKPldRESIGEYELTVEATDSGGP 79
Cadherin pfam00028
Cadherin domain;
1368-1457 5.20e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.21  E-value: 5.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1368 YQTDVSERVAVGTQIYTLKASGESLGTKPLVFNLFSVDDVamEDKIRVEPSSGNVIVMEPLDYEAARRIRAVVQVQ---Q 1444
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGP--GGNFRIDPDTGDISTTKPLDRESIGEYELTVEATdsgG 78

                           90
                   ....*....|...
gi 1061385181 1445 ANMKSFATFSVNI 1457
Cdd:pfam00028   79 PPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 516-549 5.20e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.87  E-value: 5.20e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1061385181   516 ATDQDEGENGKIVYKFTSE---LPLEINANTGEITLV 549
Cdd:smart00112    2 ATDADSGENGKVTYSILSGnddGLFSIDPETGEITTT 38
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2837-2903 7.47e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.10  E-value: 7.47e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1061385181  2837 DDDLSPNNVSQFFIPKGNEEGVFWIDSNNDLLLKRPEI-VENKMQYQLKVTAFDG---VFETSTKVKINLK 2903
Cdd:smart00112    4 DADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLdREEQPEYTLTVEATDGggpPLSSTATVTITVL 74
EGF_CA smart00179
Calcium-binding EGF-like domain;
3937-3966 8.00e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 8.00e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1061385181  3937 PCQHAGTCISQGKShFKCECPSRYS-GNVCE 3966
Cdd:smart00179   10 PCQNGGTCVNTVGS-YRCECPPGYTdGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 3710-3749 9.84e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 9.84e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1061385181 3710 CAKS-PCEQWQLCIPSVhnSTYECVCPLGMEGDKcsvpSCQ 3749
Cdd:cd00053      2 CAASnPCSNGGTCVNTP--GSYRCVCPPGYTGDR----SCE 36
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 724-822 3.44e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 3.44e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  724 SYYLRISENEKPGKDIFKVTANDFDGGNNGKIKFSLGNNQEkSSVISIDAKTGIVKLLKSLDREDQDVHTFAIIASDEGF 803
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1061385181  804 PMRVSVTNLTISVEDVNDN 822
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1674-1779 4.65e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.78  E-value: 4.65e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1674 VYRGTIRENMPTGSSVLsksllplVVSAIDEDPGSNGLVGYRMLSPKDEQMFSVDQYSGAIRTQMSFDFEKMKEYSFYVQ 1753
Cdd:cd11304      1 SYEVSVPENAPPGTVVL-------TVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVT 73

                           90       100
                   ....*....|....*....|....*.
gi 1061385181 1754 AFDMGQPPRRSlmPSLIVVTVIDEND 1779
Cdd:cd11304     74 ATDGGGPPLSS--TATVTITVLDVND 97
LamG smart00282
Laminin G domain;
3781-3907 5.02e-26

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 105.88  E-value: 5.02e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  3781 ELEIELKTTTHNGIIMW--SRGKRDFHMLRLVNGTPEYHWNAGTGTGIVTSKTSVV-DGQWHRIAISRRQRRTRMTVDDE 3857
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLnDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 1061385181  3858 DLQEAFSPIGSTVINLHrysQKLVLGAKVDDGEL-----TDGVSACFRTISVDGM 3907
Cdd:smart00282   81 NRVSGESPGGLTILNLD---GPLYLGGLPEDLKLpplpvTPGFRGCIRNLKVNGK 132
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2718-2808 1.29e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.55  E-value: 1.29e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2718 RFTISEDAAVGTSVTIFSAMDRDDSPSGRIRFSLVEENP--YFDLNENSGWLTVASQLDREKIDHYKLIARATDEGG--F 2793
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGppL 82

                           90
                   ....*....|....*
gi 1061385181 2794 NTDLPFTIVVSDVND 2808
Cdd:cd11304     83 SSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3221-3322 3.72e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 3.72e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3221 YVGKVKENSKSGEKVLTVKALDVDSEHFGAVSYELeivsetTTDTPVLPFAINSN-GDVLISQSIDYEKIKKYNLKVIAK 3299
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI------VSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|...
gi 1061385181 3300 DGGRPPLRSEALLEIHVEDENDH 3322
Cdd:cd11304     76 DGGGPPLSSTATVTITVLDVNDN 98
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 3760-3905 2.32e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 102.11  E-value: 2.32e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3760 LSVGGDGYFEISLSNEIETRMELEIELKTTTHNGIIMW--SRGKRDFHMLRLVNGTPEYHWNAGTGTGIVTSKTSVVDGQ 3837
Cdd:cd00110      2 VSFSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYagSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQ 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1061385181 3838 WHRIAISRRQRRTRMTVDDEDLQEAFSPIGSTVINLHrysQKLVLGAKVDDGEL-----TDGVSACFRTISVD 3905
Cdd:cd00110     82 WHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLD---GPLYLGGLPEDLKSpglpvSPGFVGCIRDLKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3117-3212 8.76e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.54  E-value: 8.76e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3117 TYSMKVMESESIGYELAHFRASGGDQ--NETIEYYLKPSDVTSFVNLNAQTGILTLAKPLDFETLSALKLTVVAKDSGVP 3194
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSgeNGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1061385181 3195 PLETEAQVEISVMDENDN 3212
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2510-2598 5.78e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 5.78e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2510 YSTSISESAKEGDTVMMVSATDDDE--NDTIEYSLLDGSESQFFSVHPRQGTITVAKKLEHKAGVTLSLTIKATDSANPP 2587
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSgeNGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|.
gi 1061385181 2588 HHATTTVEVNI 2598
Cdd:cd11304     82 LSSTATVTITV 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 743-824 9.07e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.03  E-value: 9.07e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181   743 TANDFDGGNNGKIKFSLgNNQEKSSVISIDAKTGIVKLLKSLDREDQDVHTFAIIASDEGFPMRVSVTNLTISVEDVNDN 822
Cdd:smart00112    1 SATDADSGENGKVTYSI-LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1061385181   823 PP 824
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1700-1782 3.15e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.49  E-value: 3.15e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  1700 SAIDEDPGSNGLVGYRMLSPKDEQMFSVDQYSGAIRTQMSFDFEKMKEYSFYVQAFDMGQPPRRSlmPSLIVVTVIDEND 1779
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSS--TATVTITVLDVND 78


                    ...
gi 1061385181  1780 EPP 1782
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1473-1562 7.91e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.07  E-value: 7.91e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1473 FAFVDESDTVDDVLATVTAFDKDRGENGIVTYSIVSGNEESLFKIDAKSGEVRLAKPLDPELQHvESILRIRAIDSAANS 1552
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQS-SYTLTVTATDGGGPP 81

                           90
                   ....*....|
gi 1061385181 1553 LKDEMSLHIR 1562
Cdd:cd11304     82 LSSTATVTIT 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 940-1042 2.62e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 2.62e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  940 EASVYENSEIGTEVIMIEAKetgDEQKVKAENLEYRIIGGDGWPHFSIDQK-GTVRTTHLLDRETKSAYWITVEARDSKT 1018
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSAT---DPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90       100
                   ....*....|....*....|....
gi 1061385181 1019 dlykdPRRRDVLHVFIRILDRNDH 1042
Cdd:cd11304     80 -----PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1051-1152 3.18e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.14  E-value: 3.18e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1051 YIASVAENSPANVVIVKVEATDADDVDNDaaaPLMFKIERGDPQSFFRIDLTSGYITTsgIRRLDREKQSEHELWVSICD 1130
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENG---EVTYSIVSGNEDGLFSIDPSTGEITT--AKPLDREEQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|..
gi 1061385181 1131 GGEPQLCSNVIVIVNVLDENDN 1152
Cdd:cd11304     77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 615-716 7.85e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.98  E-value: 7.85e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  615 VEVTEDAPIGTVVAKLQANDEDTGYNGFIRYVIHDiaGSSHEVLTVDEQSGEITVAsdlSKLMKEKLEVLdvQLKVSAID 694
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS--GNEDGLFSIDPSTGEITTA---KPLDREEQSSY--TLTVTATD 76

                           90       100
                   ....*....|....*....|..
gi 1061385181  695 AGTPVKSSVKTMKLRIKDVNNH 716
Cdd:cd11304     77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2191-2280 1.34e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.60  E-value: 1.34e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2191 YTASTPESTSIGQRLLTIKATTSDE--NDTIEYSLSGSKDIE---IHPETGDVTITGQLDYEKTQKYDLKLVATSSGK-Q 2264
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSgeNGEVTYSIVSGNEDGlfsIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpP 81

                           90
                   ....*....|....*.
gi 1061385181 2265 VSSEAEFIVLIEDVND 2280
Cdd:cd11304     82 LSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
2719-2804 2.35e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.43  E-value: 2.35e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2719 FTISEDAAVGTSVTIFSAMDRDDSPSGRIRFSLVEENPY--FDLNENSGWLTVASQLDREKIDHYKLIARATDEGGFNTD 2796
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82


                   ....*...
gi 1061385181 2797 LPFTIVVS 2804
Cdd:pfam00028   83 STATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2735-2811 8.84e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.55  E-value: 8.84e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  2735 SAMDRDDSPSGRIRFSLVEENP--YFDLNENSGWLTVASQLDREKIDHYKLIARATDEGGFN--TDLPFTIVVSDVNDSP 2810
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDdgLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPlsSTATVTITVLDVNDNA 80


                    .
gi 1061385181  2811 P 2811
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3141-3214 1.06e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.17  E-value: 1.06e-18
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1061385181  3141 DQNETIEYYLKPSDVTSFVNLNAQTGILTLAKPLDFETLSALKLTVVAKDSGVPPLETEAQVEISVMDENDNAP 3214
Cdd:smart00112    8 GENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3018-3109 1.65e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.52  E-value: 1.65e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3018 VSIDENLPtsedARQYITRIVAEDAD---FDEIKFRMV-DDFGGLFQIDDINGVVTVVKPLDSEILGFFNLTVVASDGE- 3092
Cdd:cd11304      4 VSVPENAP----PGTVVLTVSATDPDsgeNGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGg 79

                           90
                   ....*....|....*....
gi 1061385181 3093 --FEDKATILVTVIDQNDN 3109
Cdd:cd11304     80 ppLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1675-1775 3.01e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.35  E-value: 3.01e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1675 YRGTIRENMPTGSSVLSksllplvVSAIDEDPGSNGLVGYRMLSPKDEQMFSVDQYSGAIRTQMSFDFEKMKEYSFYVQA 1754
Cdd:pfam00028    1 YSASVPENAPVGTEVLT-------VTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA 73

                           90       100
                   ....*....|....*....|.
gi 1061385181 1755 FDMGQPPRRSlmPSLIVVTVI 1775
Cdd:pfam00028   74 TDSGGPPLSS--TATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3239-3324 7.32e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.86  E-value: 7.32e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  3239 KALDVDSEHFGAVSYELeivsetTTDTPVLPFAINSN-GDVLISQSIDYEKIKKYNLKVIAKDGGRPPLRSEALLEIHVE 3317
Cdd:smart00112    1 SATDADSGENGKVTYSI------LSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                    ....*..
gi 1061385181  3318 DENDHAP 3324
Cdd:smart00112   75 DVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1084-1154 3.06e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.93  E-value: 3.06e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1061385181  1084 LMFKIERGDPQSFFRIDLTSGYITTSgiRRLDREKQSEHELWVSICDGGEPQLCSNVIVIVNVLDENDNSP 1154
Cdd:smart00112   13 VTYSILSGNDDGLFSIDPETGEITTT--KPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2612-2708 3.43e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 79.66  E-value: 3.43e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2612 HYLFSVMEDADVGNVIGRVQQM---ETEIDEIRFTIVPGSEESdsflPFSVERSTGKIIVKSSLDRERKNQWKMTIRA-D 2687
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSGNEDG----LFSIDPSTGEITTAKPLDREEQSSYTLTVTAtD 76

                           90       100
                   ....*....|....*....|..
gi 1061385181 2688 AAGGVH-AITTVTVDIGDVNDN 2708
Cdd:cd11304     77 GGGPPLsSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 832-925 4.46e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 79.28  E-value: 4.46e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  832 RARIPEDLPHGAFVSCMAAFDEDIGQNSKLKFLL--NSEKVPFRIDHHSGCIFIHAPeypLDYHKTPFFNLSIEVADHGD 909
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKP---LDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*.
gi 1061385181  910 PILSTSCHLHVELVDI 925
Cdd:cd11304     80 PPLSSTATVTITVLDV 95
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1490-1562 1.62e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.31  E-value: 1.62e-15
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1061385181  1490 TAFDKDRGENGIVTYSIVSGNEESLFKIDAKSGEVRLAKPLDPELQHVESiLRIRAIDSAANSLKDEMSLHIR 1562
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYT-LTVEATDGGGPPLSSTATVTIT 72
Cadherin pfam00028
Cadherin domain;
725-817 1.65e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.64  E-value: 1.65e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  725 YYLRISENEKPGKDIFKVTANDFDGGNNGKIKFSLGNnQEKSSVISIDAKTGIVKLLKSLDREDQDVHTFAIIASDEGFP 804
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILG-GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1061385181  805 MRVSVTNLTISVE 817
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1474-1561 3.96e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.49  E-value: 3.96e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1474 AFVDESDTVDDVLATVTAFDKDRGENGIVTYSIVSGNEESLFKIDAKSGEVRLAKPLDPELQHvESILRIRAIDSAANSL 1553
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIG-EYELTVEATDSGGPPL 81


                   ....*...
gi 1061385181 1554 KDEMSLHI 1561
Cdd:pfam00028   82 SSTATVTI 89
Cadherin pfam00028
Cadherin domain;
3118-3206 1.19e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 1.19e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3118 YSMKVMESESIGYELAHFRASGGD--QNETIEYYLKPSDVTSFVNLNAQTGILTLAKPLDFETLSALKLTVVAKDSGVPP 3195
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDlgPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1061385181 3196 LETEAQVEISV 3206
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
2510-2598 1.25e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 1.25e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2510 YSTSISESAKEGDTVMMVSATDDDE--NDTIEYSLLDGSESQFFSVHPRQGTITVAKKLEHKAGVTLSLTIKATDSANPP 2587
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLgpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1061385181 2588 HHATTTVEVNI 2598
Cdd:pfam00028   81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3038-3111 1.35e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.61  E-value: 1.35e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  3038 VAEDADFDE---IKFRMVDDF-GGLFQIDDINGVVTVVKPLDSEILGFFNLTVVASDG---EFEDKATILVTVIDQNDNA 3110
Cdd:smart00112    1 SATDADSGEngkVTYSILSGNdDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVNDNA 80


                    .
gi 1061385181  3111 P 3111
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 971-1044 2.16e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.84  E-value: 2.16e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1061385181   971 NLEYRIIGGDGWPHFSIDQK-GTVRTTHLLDRETKSAYWITVEARDSKTdlykdPRRRDVLHVFIRILDRNDHRP 1044
Cdd:smart00112   12 KVTYSILSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGG-----PPLSSTATVTITVLDVNDNAP 81
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 3786-3906 2.73e-14

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 72.45  E-value: 2.73e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3786 LKTTTHNGIIMWSRGKR-DFHMLRLVNGTPEYHWNAGTGTGIVTSKTSVV-DGQWHRIAISRRQRRTRMTVDDEDLQEAF 3863
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGsDFLALELVNGRLVLRYDLGSGPESLLSSGKNLnDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1061385181 3864 SPIGSTVINLHRYsqkLVLGAKVDDGEL-----TDGVSACFRTISVDG 3906
Cdd:pfam02210   81 PPGESLLLNLNGP---LYLGGLPPLLLLpalpvRAGFVGCIRDVRVNG 125
Laminin_G_1 pfam00054
Laminin G domain;
3787-3910 5.34e-14

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 71.58  E-value: 5.34e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3787 KTTTHNGIIMW--SRGKRDFHMLRLVNGTPEYHWNAGTGTGIVTSKTSVVDGQWHRIAISRRQRRTRMTVDDEDLQEAFS 3864
Cdd:pfam00054    2 RTTEPSGLLLYngTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGES 81

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1061385181 3865 PIGSTV-INLHRysqKLVLG------AKVDDGELTDGVSACFRTISVDGMKVL 3910
Cdd:pfam00054   82 PLGATTdLDVDG---PLYVGglpslgVKKRRLAISPSFDGCIRDVIVNGKPLD 131
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2528-2598 1.01e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 1.01e-13
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1061385181  2528 SATDDDE--NDTIEYSLLDGSESQFFSVHPRQGTITVAKKLEHKAGVTLSLTIKATDSANPPHHATTTVEVNI 2598
Cdd:smart00112    1 SATDADSgeNGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 850-925 1.61e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 1.61e-13
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1061385181   850 AFDEDIGQNSKLKFLLNS--EKVPFRIDHHSGCIFIHAPeypLDYHKTPFFNLSIEVADHGDPILSTSCHLHVELVDI 925
Cdd:smart00112    2 ATDADSGENGKVTYSILSgnDDGLFSIDPETGEITTTKP---LDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76
Cadherin pfam00028
Cadherin domain;
3221-3317 2.85e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.10  E-value: 2.85e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3221 YVGKVKENSKSGEKVLTVKALDVDSEHFGAVSYELeivsetTTDTPVLPFAIN-SNGDVLISQSIDYEKIKKYNLKVIAK 3299
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI------LGGGPGGNFRIDpDTGDISTTKPLDRESIGEYELTVEAT 74

                           90
                   ....*....|....*...
gi 1061385181 3300 DGGRPPLRSEALLEIHVE 3317
Cdd:pfam00028   75 DSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2639-2710 1.88e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.45  E-value: 1.88e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1061385181  2639 EIRFTIVPGSEESdsflPFSVERSTGKIIVKSSLDRERKNQWKMTIRADAAGGV--HAITTVTVDIGDVNDNAP 2710
Cdd:smart00112   12 KVTYSILSGNDDG----LFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPplSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
2191-2276 2.73e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.40  E-value: 2.73e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2191 YTASTPESTSIGQRLLTIKATTSDE--NDTIEYSLSG---SKDIEIHPETGDVTITGQLDYEKTQKYDLKLVATSSGKQ- 2264
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLgpNGRIFYSILGggpGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPp 80

                           90
                   ....*....|..
gi 1061385181 2265 VSSEAEFIVLIE 2276
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2213-2283 3.28e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.68  E-value: 3.28e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1061385181  2213 SDENDTIEYSLSGSKD---IEIHPETGDVTITGQLDYEKTQKYDLKLVATSSGKQV-SSEAEFIVLIEDVNDEMP 2283
Cdd:smart00112    7 SGENGKVTYSILSGNDdglFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPlSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1887-1979 8.25e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.26  E-value: 8.25e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1887 EYHTSLIENTtlPPGSIILSV-ATIGDKLD----HFSIV--NPHEAFFIHPGTGVISSSGiALDREKSAIIRLVVQAKSH 1959
Cdd:cd11304      1 SYEVSVPENA--PPGTVVLTVsATDPDSGEngevTYSIVsgNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|
gi 1061385181 1960 EKNPVMARALVVVGIENIND 1979
Cdd:cd11304     78 GGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 160-254 9.45e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.26  E-value: 9.45e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  160 YEAEIDDDLEPFSTVLRVEASDADIGINSAIYFSLV--NRSHDFIVEPVTGWV---RSLRHVKPGKYSLKVKSEDRASRl 234
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEIttaKPLDREEQSSYTLTVTATDGGGP- 80

                           90       100
                   ....*....|....*....|
gi 1061385181  235 yyfdenevQPSWTADVLITV 254
Cdd:cd11304     81 --------PLSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1367-1463 1.49e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 63.49  E-value: 1.49e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1367 HYQTDVSERVAVGTQIYTLKASGESLGTKPLVFnlFSVDDVAMEDKIRVEPSSGNVIVMEPLDYEAARRIRAVVQVQ--- 1443
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVT--YSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATdgg 78

                           90       100
                   ....*....|....*....|
gi 1061385181 1444 QANMKSFATFSVNINDENDN 1463
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
833-922 1.69e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 1.69e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  833 ARIPEDLPHGAFVSCMAAFDEDIGQNSKLKFLL--NSEKVPFRIDHHSGCIFIHAPeypLDYHKTPFFNLSIEVADHGDP 910
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIDPDTGDISTTKP---LDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|..
gi 1061385181  911 ILSTSCHLHVEL 922
Cdd:pfam00028   80 PLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 631-718 7.44e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.83  E-value: 7.44e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181   631 QANDEDTGYNGFIRYVIHDiaGSSHEVLTVDEQSGEITVASDLSKlmkEKLEVLdvQLKVSAIDAGTPVKSSVKTMKLRI 710
Cdd:smart00112    1 SATDADSGENGKVTYSILS--GNDDGLFSIDPETGEITTTKPLDR---EEQPEY--TLTVEATDGGGPPLSSTATVTITV 73


                    ....*...
gi 1061385181   711 KDVNNHSP 718
Cdd:smart00112   74 LDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
615-711 4.34e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.24  E-value: 4.34e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  615 VEVTEDAPIGTVVAKLQANDEDTGYNGFIRYVIhdIAGSSHEVLTVDEQSGEITVASDLSklmKEKLEvlDVQLKVSAID 694
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI--LGGGPGGNFRIDPDTGDISTTKPLD---RESIG--EYELTVEATD 75

                           90
                   ....*....|....*..
gi 1061385181  695 AGTPVKSSVKTmkLRIK 711
Cdd:pfam00028   76 SGGPPLSSTAT--VTIT 90
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1269-1353 4.43e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.25  E-value: 4.43e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1269 YVIPISDADQVGLTVGKLEASDADGDELWW---SISSGDPDSVFDVRQDTGQLLLAKKVELLKRGELRLNISVTDG---Q 1342
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEvtySIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggpP 81

                           90
                   ....*....|.
gi 1061385181 1343 AWDHSTVIIQV 1353
Cdd:cd11304     82 LSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1175-1235 7.14e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.86  E-value: 7.14e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1061385181 1175 RIFAVDADEGENARLTYNITEGDAR--FSID-NNGNIIASEAIhgD----ESYALTVQATDHGTPGQQ 1235
Cdd:cd11304     18 TVSATDPDSGENGEVTYSIVSGNEDglFSIDpSTGEITTAKPL--DreeqSSYTLTVTATDGGGPPLS 83
Cadherin pfam00028
Cadherin domain;
940-1037 1.04e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.08  E-value: 1.04e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  940 EASVYENSEIGTEVIMIEAKetgDEQKVKAENLEYRIIGGDGWPHFSIDQK-GTVRTTHLLDRETKSAYWITVEARDSKT 1018
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTAT---DPDLGPNGRIFYSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....*....
gi 1061385181 1019 dlykdPRRRDVLHVFIRIL 1037
Cdd:pfam00028   79 -----PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 416-490 1.30e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.36  E-value: 1.30e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1061385181   416 SLIRYSLEYSksdlpNATLPFAIGSKNGILRVSAKINRSER-VYNFKVIASLHGINEKLAEKDVSIEILDSNDHAP 490
Cdd:smart00112   11 GKVTYSILSG-----NDDGLFSIDPETGEITTTKPLDREEQpEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
3018-3104 1.77e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.31  E-value: 1.77e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3018 VSIDENLPTSedarQYITRIVAEDADFDE---IKFRMV-DDFGGLFQIDDINGVVTVVKPLDSEILGFFNLTVVASDGEF 3093
Cdd:pfam00028    3 ASVPENAPVG----TEVLTVTATDPDLGPngrIFYSILgGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 1061385181 3094 ---EDKATILVTVI 3104
Cdd:pfam00028   79 pplSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 394-488 1.97e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 57.32  E-value: 1.97e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  394 EMAPIGRILYRmnVNVENPDD--VSLIRYSLEYsksdlPNATLPFAIGSKNGILRVSAKINR-SERVYNFKVIASLHGIN 470
Cdd:cd11304      8 ENAPPGTVVLT--VSATDPDSgeNGEVTYSIVS-----GNEDGLFSIDPSTGEITTAKPLDReEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1061385181  471 EKLAEKDVSIEILDSNDH 488
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3332-3418 2.21e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 57.32  E-value: 2.21e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3332 TALVQEGEAIGHRLLKFSVSDLDGPKNGaPFTVEIQGDGAKS-FKVNEKL-ELLTAKKLEYRKKDKYLLTVIAKD--VKG 3407
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDGlFSIDPSTgEITTAKPLDREEQSSYTLTVTATDggGPP 81

                           90
                   ....*....|.
gi 1061385181 3408 KTTDCPLTIFI 3418
Cdd:cd11304     82 LSSTATVTITV 92
Cadherin pfam00028
Cadherin domain;
1051-1147 2.24e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.31  E-value: 2.24e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1051 YIASVAENSPANVVIVKVEATDADDVDNDAaapLMFKIERGDPQSFFRIDLTSGYITTsgIRRLDREKQSEHELWVSICD 1130
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGR---IFYSILGGGPGGNFRIDPDTGDIST--TKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*..
gi 1061385181 1131 GGEPQLCSNVIVIVNVL 1147
Cdd:pfam00028   76 SGGPPLSSTATVTITVL 92
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3968-4004 1.25e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 53.41  E-value: 1.25e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1061385181 3968 DLEPCAS-SPCPTGIQCIPFYNDYLCKCPNGFTGKHCE 4004
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2291-2386 1.60e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.01  E-value: 1.60e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2291 SAKISDSAITGQFITIMSATDMDttnslDEESQKLLYKIVDGDET-LFNISPATGELSLARPV--EQDDLVNedtkkvLN 2367
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPD-----SGENGEVTYSIVSGNEDgLFSIDPSTGEITTAKPLdrEEQSSYT------LT 71

                           90       100
                   ....*....|....*....|..
gi 1061385181 2368 VSVTDG---MFTAYAKLVVEIL 2386
Cdd:cd11304     72 VTATDGggpPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3440-3536 1.81e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 54.63  E-value: 1.81e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3440 NELPEGIIGRLKASDEDEeDQNGLLRFGLVEGSiqspraqvqesrSTHLFRVDPNTGDIWSDHSI---TQGLHTFNVTVT 3516
Cdd:cd11304      9 NAPPGTVVLTVSATDPDS-GENGEVTYSIVSGN------------EDGLFSIDPSTGEITTAKPLdreEQSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|...
gi 1061385181 3517 DS---KFNTVSYVEVHVTSIdND 3536
Cdd:cd11304     76 DGggpPLSSTATVTITVLDV-ND 97
Cadherin pfam00028
Cadherin domain;
2613-2702 5.27e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.07  E-value: 5.27e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2613 YLFSVMEDADVGNVIGRVQQmeTEIDE-----IRFTIVPGSEESdsflPFSVERSTGKIIVKSSLDRERKNQWKMTIRAD 2687
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTA--TDPDLgpngrIFYSILGGGPGG----NFRIDPDTGDISTTKPLDRESIGEYELTVEAT 74

                           90
                   ....*....|....*
gi 1061385181 2688 AAGGVHAITTVTVDI 2702
Cdd:pfam00028   75 DSGGPPLSSTATVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1916-1982 6.04e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 52.74  E-value: 6.04e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1061385181  1916 HFSIV--NPHEAFFIHPGTGVISSSGiALDREKSAIIRLVVQAKSHEKNPVMARALVVVGIENINDETP 1982
Cdd:smart00112   14 TYSILsgNDDGLFSIDPETGEITTTK-PLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2817-2903 7.09e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 53.09  E-value: 7.09e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2817 EFNIDLHLPSTSPILHFSIKDDDLSPNNVSQFFIPKGNEEGVFWIDSNN-DLLLKRPEIVENKMQYQLKVTAFDG---VF 2892
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTgEITTAKPLDREEQSSYTLTVTATDGggpPL 82

                           90
                   ....*....|.
gi 1061385181 2893 ETSTKVKINLK 2903
Cdd:cd11304     83 SSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
3332-3418 9.19e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 52.69  E-value: 9.19e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3332 TALVQEGEAIGHRLLKFSVSDLDGPKNGAPFTVEIQGDGAKSFKVNEK-LELLTAKKLEYRKKDKYLLTVIAKD--VKGK 3408
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDsgGPPL 81

                           90
                   ....*....|
gi 1061385181 3409 TTDCPLTIFI 3418
Cdd:pfam00028   82 SSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
1175-1234 1.51e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 1.51e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1061385181 1175 RIFAVDADEGENARLTYNITEGDAR--FSIDNNGNIIAS------EAIhgdESYALTVQATDHGTPGQ 1234
Cdd:pfam00028   17 TVTATDPDLGPNGRIFYSILGGGPGgnFRIDPDTGDISTtkpldrESI---GEYELTVEATDSGGPPL 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1178-1234 1.82e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.20  E-value: 1.82e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1061385181  1178 AVDADEGENARLTYNITEGDAR--FSID-NNGNIIASEAI--HGDESYALTVQATDHGTPGQ 1234
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDglFSIDpETGEITTTKPLdrEEQPEYTLTVEATDGGGPPL 63
Cadherin pfam00028
Cadherin domain;
160-233 3.82e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.76  E-value: 3.82e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1061385181  160 YEAEIDDDLEPFSTVLRVEASDADIGINSAIYFSLV--NRSHDFIVEPVTGWVRSLRHV---KPGKYSLKVKSEDRASR 233
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPLdreSIGEYELTVEATDSGGP 79
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2449-2503 5.61e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.04  E-value: 5.61e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1061385181  2449 PVAIDRKTGRIHVSRVLNYHRDKRYQIPLVVEDATG--RRAFSTLTLSVIDINDKPP 2503
Cdd:smart00112   25 LFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 506-570 7.07e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 50.39  E-value: 7.07e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  506 KPGDVLVKVDATDQDEGENGKIVYKFTS---ELPLEINANTGEITLVEV--PKKGNSWPATVWAIDLGLP 570
Cdd:cd11304     11 PPGTVVLTVSATDPDSGENGEVTYSIVSgneDGLFSIDPSTGEITTAKPldREEQSSYTLTVTATDGGGP 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2085-2176 8.11e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 50.00  E-value: 8.11e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2085 VYTAVISkESTKKSTVLVKVMAkSSLQSKSKGLIGYRIL--DKKSPFSVDFLTGEVRLNN-LKMLAETNYTFEVEAREVT 2161
Cdd:cd11304      1 SYEVSVP-ENAPPGTVVLTVSA-TDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKpLDREEQSSYTLTVTATDGG 78

                           90
                   ....*....|....*
gi 1061385181 2162 RPKMIAKAQVEIIVK 2176
Cdd:cd11304     79 GPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1402-1465 8.89e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.27  E-value: 8.89e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1061385181  1402 FSVDDVAMEDKIRVEPSSGNVIVMEPLDYEAARRIRAVVQVQ---QANMKSFATFSVNINDENDNSP 1465
Cdd:smart00112   15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATdggGPPLSSTATVTITVLDVNDNAP 81
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 3933-3963 2.46e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 46.61  E-value: 2.46e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1061385181 3933 CNDLPCQHAGTCIsQGKSHFKCECPSRYSGN 3963
Cdd:pfam00008    1 CAPNPCSNGGTCV-DTPGGYTCICPEGYTGK 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
3972-4004 2.74e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 2.74e-06
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1061385181  3972 CAS-SPCPTGIQCIPFYNDYLCKCPNGFT-GKHCE 4004
Cdd:smart00179    5 CASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 3971-4004 8.08e-06

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 45.16  E-value: 8.08e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1061385181 3971 PCA-SSPCPTGIQCIPFYNDYLCKCPNGFTG-KHCE 4004
Cdd:cd00053      1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 3972-4002 8.38e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 45.07  E-value: 8.38e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1061385181 3972 CASSPCPTGIQCIPFYNDYLCKCPNGFTGKH 4002
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2451-2500 1.48e-05

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 46.54  E-value: 1.48e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1061385181 2451 AIDRKTGRIHVSRVLNYHRDKRYQIPLVVEDATG--RRAFSTLTLSVIDIND 2500
Cdd:cd11304     46 SIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGppLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
1888-1975 1.51e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 46.14  E-value: 1.51e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1888 YHTSLIENTtlPPGSIILSV-ATIGDKLDH----FSIVNPHEA--FFIHPGTGVISSsGIALDREKSAIIRLVVQAKSHE 1960
Cdd:pfam00028    1 YSASVPENA--PVGTEVLTVtATDPDLGPNgrifYSILGGGPGgnFRIDPDTGDIST-TKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1061385181 1961 KNPVMARALVVVGIE 1975
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 731-822 3.34e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 45.41  E-value: 3.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  731 ENEKPGKDIFKVtANDFDGGNNGKIKFSLGNNQEKSSVISIDAKTGIVKLLKSLDREDQDVHTFAIIASDEGFPMRVSVT 810
Cdd:cd00031      8 EGRSRGSFRVSI-PTDLIASSGEIIKISAAGKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQTSS 86

                           90
                   ....*....|..
gi 1061385181  811 NLTISVEDVNDN 822
Cdd:cd00031     87 VFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
1269-1353 5.60e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 44.60  E-value: 5.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1269 YVIPISDADQVGLTVGKLEASDADGDELW---WSISSGDPDSVFDVRQDTGQLLLAKKVELLKRGELRLNISVTDGQAWD 1345
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGrifYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1061385181 1346 HS---TVIIQV 1353
Cdd:pfam00028   81 LSstaTVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3451-3541 1.21e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 43.49  E-value: 1.21e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  3451 KASDEDEeDQNGLLRFGLVEGSIQspraqvqesrstHLFRVDPNTGDIWSDHSI---TQGLHTFNVTVTDS---KFNTVS 3524
Cdd:smart00112    1 SATDADS-GENGKVTYSILSGNDD------------GLFSIDPETGEITTTKPLdreEQPEYTLTVEATDGggpPLSSTA 67

                            90
                    ....*....|....*..
gi 1061385181  3525 YVEVHVTsidnDVIDHA 3541
Cdd:smart00112   68 TVTITVL----DVNDNA 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3349-3426 1.75e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 42.72  E-value: 1.75e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181  3349 SVSDLDGPKNGAPFTVEIQGDGAKSFKVNEKL-ELLTAKKLEYRKKDKYLLTVIAKD--VKGKTTDCPLTIFIRQTSRHA 3425
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETgEITTTKPLDREEQPEYTLTVEATDggGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1061385181  3426 P 3426
Cdd:smart00112   81 P 81
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3937-3966 2.26e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 2.26e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1061385181 3937 PCQHAGTCISQGKShFKCECPSRYSGNVCE 3966
Cdd:cd00054     10 PCQNGGTCVNTVGS-YRCSCPPGYTGRNCE 38
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 179-254 3.22e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.95  E-value: 3.22e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181   179 ASDADIGINSAIYFSLVNRSHD--FIVEPVTGWVRSLRHV---KPGKYSLKVKSEDRASRlyyfdenevQPSWTADVLIT 253
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDglFSIDPETGEITTTKPLdreEQPEYTLTVEATDGGGP---------PLSSTATVTIT 72


                    .
gi 1061385181   254 V 254
Cdd:smart00112   73 V 73
Cadherin pfam00028
Cadherin domain;
3440-3531 3.65e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 42.29  E-value: 3.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 3440 NELPEGIIGRLKASDEDEEdQNGLLRFGLVEGSIQspraqvqesrstHLFRVDPNTGDIWSDHSI---TQGLHTFNVTVT 3516
Cdd:pfam00028    8 NAPVGTEVLTVTATDPDLG-PNGRIFYSILGGGPG------------GNFRIDPDTGDISTTKPLdreSIGEYELTVEAT 74

                           90
                   ....*....|....*.
gi 1061385181 3517 DS-KFNTVSYVEVHVT 3531
Cdd:pfam00028   75 DSgGPPLSSTATVTIT 90
EGF smart00181
Epidermal growth factor-like domain;
3971-4004 5.73e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 40.19  E-value: 5.73e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1061385181  3971 PCAS-SPCPTGiQCIPFYNDYLCKCPNGFTG-KHCE 4004
Cdd:smart00181    1 ECASgGPCSNG-TCINTPGSYTCSCPPGYTGdKRCE 35
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1988-2075 9.05e-04

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 41.53  E-value: 9.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1988 PYDITIG-HSDIGTVVLEPKVIDNDEGD----VVTISSENMPEYFKI--VGGKVVLGKKLPSieEEDLEFNFKLIAKDNG 2060
Cdd:cd11304      1 SYEVSVPeNAPPGTVVLTVSATDPDSGEngevTYSIVSGNEDGLFSIdpSTGEITTAKPLDR--EEQSSYTLTVTATDGG 78

                           90
                   ....*....|....*.
gi 1061385181 2061 SVHRVEE-PVKIRVVD 2075
Cdd:cd11304     79 GPPLSSTaTVTITVLD 94
Cadherin pfam00028
Cadherin domain;
2291-2386 9.41e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 41.13  E-value: 9.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 2291 SAKISDSAITGQFITIMSATDMDTTnsldeESQKLLYKIVDGDET-LFNISPATGELSLARPV--EQDDLVNedtkkvLN 2367
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLG-----PNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLdrESIGEYE------LT 70

                           90       100
                   ....*....|....*....|...
gi 1061385181 2368 VSVTD----GMfTAYAKLVVEIL 2386
Cdd:pfam00028   71 VEATDsggpPL-SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2941-3009 1.01e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 40.80  E-value: 1.01e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1061385181  2941 NVTFKL-SDNDGNVFVVNFRNGIVKVKEsdQIDYEKNQQLEFhRLTIQDNSEVCKE---LITVVIENLNDNRP 3009
Cdd:smart00112   12 KVTYSIlSGNDDGLFSIDPETGEITTTK--PLDREEQPEYTL-TVEATDGGGPPLSstaTVTITVLDVNDNAP 81
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 3932-3966 1.32e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 39.00  E-value: 1.32e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1061385181 3932 PCNDL-PCQHAGTCISQGKShFKCECPSRYSGNV-CE 3966
Cdd:cd00053      1 ECAASnPCSNGGTCVNTPGS-YRCVCPPGYTGDRsCE 36
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3157-3212 1.83e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 40.41  E-value: 1.83e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1061385181 3157 SFVNLNAQTGILTLAKPLDFETLSALKLTVVAKDSGVPPLETEAQVEISVMDENDN 3212
Cdd:cd00031     43 SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
507-570 3.77e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.59  E-value: 3.77e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1061385181  507 PGDVLVKVDATDQDEGENGKIVYKFTSELP---LEINANTGEITLVEV--PKKGNSWPATVWAIDLGLP 570
Cdd:pfam00028   11 VGTEVLTVTATDPDLGPNGRIFYSILGGGPggnFRIDPDTGDISTTKPldRESIGEYELTVEATDSGGP 79
Cadherin pfam00028
Cadherin domain;
1368-1457 5.20e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.21  E-value: 5.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385181 1368 YQTDVSERVAVGTQIYTLKASGESLGTKPLVFNLFSVDDVamEDKIRVEPSSGNVIVMEPLDYEAARRIRAVVQVQ---Q 1444
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGP--GGNFRIDPDTGDISTTKPLDRESIGEYELTVEATdsgG 78

                           90
                   ....*....|...
gi 1061385181 1445 ANMKSFATFSVNI 1457
Cdd:pfam00028   79 PPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 516-549 5.20e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.87  E-value: 5.20e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1061385181   516 ATDQDEGENGKIVYKFTSE---LPLEINANTGEITLV 549
Cdd:smart00112    2 ATDADSGENGKVTYSILSGnddGLFSIDPETGEITTT 38
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2837-2903 7.47e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.10  E-value: 7.47e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1061385181  2837 DDDLSPNNVSQFFIPKGNEEGVFWIDSNNDLLLKRPEI-VENKMQYQLKVTAFDG---VFETSTKVKINLK 2903
Cdd:smart00112    4 DADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLdREEQPEYTLTVEATDGggpPLSSTATVTITVL 74
EGF_CA smart00179
Calcium-binding EGF-like domain;
3937-3966 8.00e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 8.00e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1061385181  3937 PCQHAGTCISQGKShFKCECPSRYS-GNVCE 3966
Cdd:smart00179   10 PCQNGGTCVNTVGS-YRCECPPGYTdGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 3710-3749 9.84e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 9.84e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1061385181 3710 CAKS-PCEQWQLCIPSVhnSTYECVCPLGMEGDKcsvpSCQ 3749
Cdd:cd00053      2 CAASnPCSNGGTCVNTP--GSYRCVCPPGYTGDR----SCE 36
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 3938-3965 9.95e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 36.17  E-value: 9.95e-03
                           10        20
                   ....*....|....*....|....*...
gi 1061385181 3938 CQHAGTCISQGkshFKCECPSRYSGNVC 3965
Cdd:pfam07974    2 CSGRGTCVNQC---GKCVCDSGYQGATC 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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