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Conserved domains on  [gi|1063692445|ref|NP_001319369|]
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Mannose-binding lectin superfamily protein [Arabidopsis thaliana]

Protein Classification

jacalin family lectin( domain architecture ID 10176320)

jacalin family lectin is a sugar-binding protein containing a jacalin domain

Gene Ontology:  GO:0030246
PubMed:  15329359|28737678
SCOP:  4002758

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Jacalin cd09612
Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains ...
 23-153 4.37e-50

Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. The family was initially named after an abundant protein found in the jackfruit seed. Jacalin specifically binds to the alpha-O-glycoside of the disaccharide Gal-beta1-3-GalNAc, and has proven useful in the study of O-linked glycoproteins. Jacalin-like lectins in this family may occur in various oligomerization states.


:

Pssm-ID: 187708 [Multi-domain]  Cd Length: 130  Bit Score: 157.34  E-value: 4.37e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063692445  23 GTTWDDGIY-DGVREIRLVYDH-CIDSISVIYDKNGKPAKSEKHGGvGGNKTSEIKLQYPEEYLTGVSGYYCPmvNSGTP 100
Cdd:cd09612     1 GSAWDDGVFpDGLRKITVRSGEnGIDSIKFEYDKDGQHVVGPWHGG-GGGTPEEIVLDYPDEYITSVSGTYGP--VSGSN 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1063692445 101 VIRSMTFKSNKQVYGPYGVEQGTPFTFSVNGGRIVGMNGRSGWYLDSIGFHLS 153
Cdd:cd09612    78 VITSLTFKTNKRTYGPFGVESGTPFSLPVEGGKIVGFHGRSGDYLDAIGVYVS 130
 
Name Accession Description Interval E-value
Jacalin cd09612
Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains ...
 23-153 4.37e-50

Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. The family was initially named after an abundant protein found in the jackfruit seed. Jacalin specifically binds to the alpha-O-glycoside of the disaccharide Gal-beta1-3-GalNAc, and has proven useful in the study of O-linked glycoproteins. Jacalin-like lectins in this family may occur in various oligomerization states.


Pssm-ID: 187708 [Multi-domain]  Cd Length: 130  Bit Score: 157.34  E-value: 4.37e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063692445  23 GTTWDDGIY-DGVREIRLVYDH-CIDSISVIYDKNGKPAKSEKHGGvGGNKTSEIKLQYPEEYLTGVSGYYCPmvNSGTP 100
Cdd:cd09612     1 GSAWDDGVFpDGLRKITVRSGEnGIDSIKFEYDKDGQHVVGPWHGG-GGGTPEEIVLDYPDEYITSVSGTYGP--VSGSN 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1063692445 101 VIRSMTFKSNKQVYGPYGVEQGTPFTFSVNGGRIVGMNGRSGWYLDSIGFHLS 153
Cdd:cd09612    78 VITSLTFKTNKRTYGPFGVESGTPFSLPVEGGKIVGFHGRSGDYLDAIGVYVS 130
Jacalin pfam01419
Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 ...
 23-151 9.07e-39

Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 copies in these proteins. The domain is also found in the animal prostatic spermine-binding protein.


Pssm-ID: 396138 [Multi-domain]  Cd Length: 134  Bit Score: 128.93  E-value: 9.07e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063692445  23 GTTWDDGIYDGVREIRLVYDH-CIDSISVIYDKNGKPAKSEKHGGVGGNKTSEIKLQYPEEYLTGVSGYYCPMVNSGTPV 101
Cdd:pfam01419   1 GASWDDGVYDGVRKVYVGQGGdGITYIKFEYVKGGGKVEGDEHGKKGLLGPEEFEIDYPDEYITSVEGTYDKVFGSDSEV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063692445 102 IRSMTFKSNKQVYGP-YGVEQGTPFTFSVNGGRIVGMNGRSGWYLDSIGFH 151
Cdd:pfam01419  81 ITSLTFKTNKGRTSPfFGTPSGTKFSLEVKGKKIVGFHGRAGNALNALGAY 131
Jacalin smart00915
Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a ...
 23-153 2.22e-36

Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B- cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.


Pssm-ID: 214909 [Multi-domain]  Cd Length: 128  Bit Score: 122.72  E-value: 2.22e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063692445   23 GTTWDDGIYDGVREIRLVYD-HCIDSISVIYDKnGKPAKSEKHGGVGGnkTSEIKLQYPEEYLTGVSGYYCPmvnsgTPV 101
Cdd:smart00915   1 GTEWDDGAFDGVRKIYVGQGgEGIKSIQFDYDK-GGKVWGDEHGGKGG--TGEEILLYPGEYITSVEGTYDK-----SGV 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1063692445  102 IRSMTFKSNK-QVYGPYGVEQGTPFTF-SVNGGRIVGMNGR-SGWYLDSIGFHLS 153
Cdd:smart00915  73 ITSLTFKTNKgRTSPFGGYEGGTKFVLeSKEGKKIVGFHGRsSGDGLDSLGAYFS 127
PLN02193 PLN02193
nitrile-specifier protein
 19-166 6.66e-14

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 68.44  E-value: 6.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063692445  19 GGNGGTTWDDGIYDGVREIRL----------VYDHCIDSISVIYDKNGKpaKSEKhggvgGNKTSEIKlqyPEEYLTGVS 88
Cdd:PLN02193    9 GGETGDVWDDGVYDNVRKVYVgqgqygiafvKFEYVNGSQVVVGDEHGK--KTEL-----GVEEFEID---ADDYIVYVE 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063692445  89 GYYCPMVNSGTPVIRSMTFKSNK-QVYGPYGVEQGTPFTfsVNGGRIVGMNGRSGWYLDSIGFHLSRPKSTKMINKLRK 166
Cdd:PLN02193   79 GYREKVNDMTSEMITFLSFKTYKgKTSHPIEKRPGVKFV--LQGGKIVGFHGRSTDVLHSLGAYISLPSTPKLLGKWIK 155
 
Name Accession Description Interval E-value
Jacalin cd09612
Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains ...
 23-153 4.37e-50

Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. The family was initially named after an abundant protein found in the jackfruit seed. Jacalin specifically binds to the alpha-O-glycoside of the disaccharide Gal-beta1-3-GalNAc, and has proven useful in the study of O-linked glycoproteins. Jacalin-like lectins in this family may occur in various oligomerization states.


Pssm-ID: 187708 [Multi-domain]  Cd Length: 130  Bit Score: 157.34  E-value: 4.37e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063692445  23 GTTWDDGIY-DGVREIRLVYDH-CIDSISVIYDKNGKPAKSEKHGGvGGNKTSEIKLQYPEEYLTGVSGYYCPmvNSGTP 100
Cdd:cd09612     1 GSAWDDGVFpDGLRKITVRSGEnGIDSIKFEYDKDGQHVVGPWHGG-GGGTPEEIVLDYPDEYITSVSGTYGP--VSGSN 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1063692445 101 VIRSMTFKSNKQVYGPYGVEQGTPFTFSVNGGRIVGMNGRSGWYLDSIGFHLS 153
Cdd:cd09612    78 VITSLTFKTNKRTYGPFGVESGTPFSLPVEGGKIVGFHGRSGDYLDAIGVYVS 130
Jacalin pfam01419
Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 ...
 23-151 9.07e-39

Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 copies in these proteins. The domain is also found in the animal prostatic spermine-binding protein.


Pssm-ID: 396138 [Multi-domain]  Cd Length: 134  Bit Score: 128.93  E-value: 9.07e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063692445  23 GTTWDDGIYDGVREIRLVYDH-CIDSISVIYDKNGKPAKSEKHGGVGGNKTSEIKLQYPEEYLTGVSGYYCPMVNSGTPV 101
Cdd:pfam01419   1 GASWDDGVYDGVRKVYVGQGGdGITYIKFEYVKGGGKVEGDEHGKKGLLGPEEFEIDYPDEYITSVEGTYDKVFGSDSEV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063692445 102 IRSMTFKSNKQVYGP-YGVEQGTPFTFSVNGGRIVGMNGRSGWYLDSIGFH 151
Cdd:pfam01419  81 ITSLTFKTNKGRTSPfFGTPSGTKFSLEVKGKKIVGFHGRAGNALNALGAY 131
Jacalin smart00915
Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a ...
 23-153 2.22e-36

Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B- cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.


Pssm-ID: 214909 [Multi-domain]  Cd Length: 128  Bit Score: 122.72  E-value: 2.22e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063692445   23 GTTWDDGIYDGVREIRLVYD-HCIDSISVIYDKnGKPAKSEKHGGVGGnkTSEIKLQYPEEYLTGVSGYYCPmvnsgTPV 101
Cdd:smart00915   1 GTEWDDGAFDGVRKIYVGQGgEGIKSIQFDYDK-GGKVWGDEHGGKGG--TGEEILLYPGEYITSVEGTYDK-----SGV 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1063692445  102 IRSMTFKSNK-QVYGPYGVEQGTPFTF-SVNGGRIVGMNGR-SGWYLDSIGFHLS 153
Cdd:smart00915  73 ITSLTFKTNKgRTSPFGGYEGGTKFVLeSKEGKKIVGFHGRsSGDGLDSLGAYFS 127
Jacalin_like cd09302
Jacalin-like lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly ...
 23-153 6.16e-15

Jacalin-like lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. Taxonomic distribution is not restricted to plants, the domain is also found in various mammalian proteins, for example.


Pssm-ID: 187706  Cd Length: 128  Bit Score: 67.43  E-value: 6.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063692445  23 GTTWDDGIYDG--VREIRLVYDHCIDSISVIYDKNGKPakseKHGGVGGNKTSEIKLQyPEEYLTGVSGYYcpMVNSGTP 100
Cdd:cd09302     1 GKPFSDTGGDGarLTEIRVRSGGAVDAIRVVLRDYTDG----RHGGNGGPNTSSVFLD-PGEYITITSVSS--GDNGGGT 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1063692445 101 VIRSMTFKSNKQVYGPYGV---EQGTPFTFSVnGGRIVGMNGRSGWYLDSIGFHLS 153
Cdd:cd09302    74 RIDAIQFTTNKGRSGTYGTtsgALGTEFTVPV-GGEIVGIYGRAGDDVDAFGFILS 128
PLN02193 PLN02193
nitrile-specifier protein
 19-166 6.66e-14

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 68.44  E-value: 6.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063692445  19 GGNGGTTWDDGIYDGVREIRL----------VYDHCIDSISVIYDKNGKpaKSEKhggvgGNKTSEIKlqyPEEYLTGVS 88
Cdd:PLN02193    9 GGETGDVWDDGVYDNVRKVYVgqgqygiafvKFEYVNGSQVVVGDEHGK--KTEL-----GVEEFEID---ADDYIVYVE 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063692445  89 GYYCPMVNSGTPVIRSMTFKSNK-QVYGPYGVEQGTPFTfsVNGGRIVGMNGRSGWYLDSIGFHLSRPKSTKMINKLRK 166
Cdd:PLN02193   79 GYREKVNDMTSEMITFLSFKTYKgKTSHPIEKRPGVKFV--LQGGKIVGFHGRSTDVLHSLGAYISLPSTPKLLGKWIK 155
griffithsin_like cd09614
Jacalin-like lectin domain of griffithsin and related proteins; Griffithsin is a lectin ...
 20-151 3.74e-12

Jacalin-like lectin domain of griffithsin and related proteins; Griffithsin is a lectin isolated from a red alga, which has shown potential as an inhibitor of viral entry, exhibiting antiviral activity against HIV and SARS. The biological functions of griffithsin and griffithsin-like proteins with respect to their source organisms are not known.


Pssm-ID: 187710  Cd Length: 128  Bit Score: 60.10  E-value: 3.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063692445  20 GNGGTTWDDGIYDGVREIRLVYDHCIDSISVIYDKNGKPAKSeKHGGVGGNKTSEIKLqYPEEYLTGVSGYYCPMVNSgt 99
Cdd:cd09614     1 GFGGSPGSDFDILTVSAIQLRSGSYVDQIITDYQDLNGTQNF-HHGGGGGNLSPTLNF-SSGEYITEVTGRSGDRVDQ-- 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1063692445 100 pvirsMTFKSNKQV-YGPYGVEQGTPFTFSVNGG-RIVGMNGRSGWYLDSIGFH 151
Cdd:cd09614    77 -----VQFTTNYGGrTLPGGGGGGSAFTWTVPDNqKVIGFAGRSGSYLDQLQVY 125
Jacalin_ZG16_like cd09611
Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a ...
 20-151 4.80e-08

Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a conserved secreted vertebrate protein with tissue-specific expression profiles, which might play a role in glycoprotein secretion, perhaps as a linker protein that participates in the formation and/or transport of the zymogen granule. Its paralog ZG16b (PAUF) has been associated with roles in gene regulation and cancer. This domain family also contains mammalian proteins labelled as prostatic spermine-binding protein (SBP) and salivary-gland specific secreted proteins.


Pssm-ID: 187707 [Multi-domain]  Cd Length: 128  Bit Score: 49.24  E-value: 4.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063692445  20 GNGGTTWDDGIYDGVREIRLVYDHC----IDSISVIYDKNgkpaKSEKHGGVGGNkTSEIKLQyPEEYLTGVSGYYcpmv 95
Cdd:cd09611     1 GSGGGKYFSDVGEGGGPITGIRVSVgnnyIKGIQVRYGSN----WSDVYGGRGGN-EQEIVLE-PGESITKVSGSY---- 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063692445  96 nsgTPVIRSMTFKSNKQVYGPYGVEQGTPFTFS--VNGGRIVGMNGRSGW-YLDSIGFH 151
Cdd:cd09611    71 ---KIYLHGLVFTTNKGRYLSFGKLRGRSFNATppPSNYVLRGISGRYGGlGIKSIGFH 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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