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Conserved domains on  [gi|1063694775|ref|NP_001322969|]
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Lipase/lipooxygenase, PLAT/LH2 family protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLAT super family cl00011
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 130-242 1.40e-05

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


The actual alignment was detected with superfamily member cd01756:

Pssm-ID: 412108  Cd Length: 120  Bit Score: 44.08  E-value: 1.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063694775 130 YKVKLQTSNLFGSGisdMNARVLICLIDEKGDSvlqtippNLSSLDPEVVENgesfRFQRGSLDEFSFEGPKLGKIRAFW 209
Cdd:cd01756     3 YEVTVKTGDVKGAG---TDANVFITLYGENGDT-------GKRKLKKSNNKN----KFERGQTDKFTVEAVDLGKLKKIR 68

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1063694775 210 I-----GLESGqWRVGRVSLWVVNpRGKETeakTF-CYR 242
Cdd:cd01756    69 IghdnsGLGAG-WFLDKVEIREPG-TGDEY---TFpCNR 102
 
Name Accession Description Interval E-value
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 130-242 1.40e-05

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 44.08  E-value: 1.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063694775 130 YKVKLQTSNLFGSGisdMNARVLICLIDEKGDSvlqtippNLSSLDPEVVENgesfRFQRGSLDEFSFEGPKLGKIRAFW 209
Cdd:cd01756     3 YEVTVKTGDVKGAG---TDANVFITLYGENGDT-------GKRKLKKSNNKN----KFERGQTDKFTVEAVDLGKLKKIR 68

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1063694775 210 I-----GLESGqWRVGRVSLWVVNpRGKETeakTF-CYR 242
Cdd:cd01756    69 IghdnsGLGAG-WFLDKVEIREPG-TGDEY---TFpCNR 102
 
Name Accession Description Interval E-value
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 130-242 1.40e-05

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 44.08  E-value: 1.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063694775 130 YKVKLQTSNLFGSGisdMNARVLICLIDEKGDSvlqtippNLSSLDPEVVENgesfRFQRGSLDEFSFEGPKLGKIRAFW 209
Cdd:cd01756     3 YEVTVKTGDVKGAG---TDANVFITLYGENGDT-------GKRKLKKSNNKN----KFERGQTDKFTVEAVDLGKLKKIR 68

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1063694775 210 I-----GLESGqWRVGRVSLWVVNpRGKETeakTF-CYR 242
Cdd:cd01756    69 IghdnsGLGAG-WFLDKVEIREPG-TGDEY---TFpCNR 102
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 130-210 4.40e-04

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 39.63  E-value: 4.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063694775 130 YKVKLQTSNLFGSGISDmnaRVLICLIDEKGDSVLQTIPPNLssldpevvengesFRFQRGSLDEFSFEGPK-LGKIRAF 208
Cdd:cd00113     3 YTVTIKTGDKKGAGTDS---NISLALYGENGNSSDIPILDGP-------------GSFERGSTDTFQIDLKLdIGDITKV 66


                  ..
gi 1063694775 209 WI 210
Cdd:cd00113    67 YL 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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