|
Name |
Accession |
Description |
Interval |
E-value |
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
169-864 |
4.48e-138 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 435.04 E-value: 4.48e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 169 RKPSRRDGKKVKVVSFREDTDFDAVFDGASAGFVETERDELVRKGILTPFHKLDGFERRLQQPGPSNSRNLPEGDDENED 248
Cdd:COG0553 25 RLGALLLELVLARELLLLLLAADALLLLALLLLLELLLLLAALLLLALLLLALSALALLLLRLLLALLLLALLLLLAGLL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 249 SSIIDRAVQSMSLAA-KARPTTKLLDAEDLPKLEPPTAPFRRLRKLYKTPNSPDNEAKKRKAGKKSKKTRPLPEKKWRKR 327
Cdd:COG0553 105 ALALLLLALLGLLLSlALLLLLLLLLLLLLLALLLVLLAALLLLLLLLLLLALLLGRLLLLALLLLALEALLLLGLLLAL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 328 ISREDSSLQGSGDGRRILTTSSCEEEELDDFDDADDNERSSVQLEGGLNIPECIFRKLFDYQRVGVQWLWELHCQRAGGI 407
Cdd:COG0553 185 ALLALLELALLAAEAELLLLLELLLELELLAEAAVDAFRLRRLREALESLPAGLKATLRPYQLEGAAWLLFLRRLGLGGL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 408 IGDEMGLGKTIQVLSFLGSLHFSKMYKPSIIICPVTLLRQWRREAQKWYPDFHVEILHDSAQdsghgkgqgkasesdyds 487
Cdd:COG0553 265 LADDMGLGKTIQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKFAPGLRVLVLDGTRE------------------ 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 488 essvdsdhepKSKNTKKWDsllnrvlnsESGLLITTYEQLRLQGEKLLNIEWGYAVLDEGHRIRNPNSDITLVCKQLQTV 567
Cdd:COG0553 327 ----------RAKGANPFE---------DADLVITSYGLLRRDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKAR 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 568 HRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEFSVPITVGGYANASplqvstayrcavVLRDLIMPYLLRRMKA 647
Cdd:COG0553 388 HRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIEKGDEEALE------------RLRRLLRPFLLRRTKE 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 648 DVNAHLTKKTEHVLFCSLTVEQRSTYRAFLAssEVEQIFDGNRNSLYGIDV------MRKICNHPDLLEREHSHQNpdyg 721
Cdd:COG0553 456 DVLKDLPEKTEETLYVELTPEQRALYEAVLE--YLRRELEGAEGIRRRGLIlaaltrLRQICSHPALLLEEGAELS---- 529
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 722 npERSGKMKVVAEVLKVWKQQGHRVLLFSQTQQMLDILESFLVANEYSYRRMDGLTPVKQRMALIDEFNNSEDMFVFVLT 801
Cdd:COG0553 530 --GRSAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLIS 607
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063704106 802 TKVGGLGTNLTGANRVIIFDPDWNPSNDMQARERAWRIGQKKDVTVYRLITRGTIEEKVYHRQ 864
Cdd:COG0553 608 LKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELL 670
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
385-593 |
1.18e-108 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 338.14 E-value: 1.18e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 385 LFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSLHFSKM-YKPSIIICPVTLLRQWRREAQKWYPDFHVEI 463
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLAALHHSKLgLGPSLIVCPATVLKQWVKEFHRWWPPFRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 464 LHDSAQDSGHGKGQGkasesdydsessvdsdhepksknTKKWDSLLNRVLNSESGLLITTYEQLRLQGEKLLNIEWGYAV 543
Cdd:cd18000 81 LHSSGSGTGSEEKLG-----------------------SIERKSQLIRKVVGDGGILITTYEGFRKHKDLLLNHNWQYVI 137
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1063704106 544 LDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFP 593
Cdd:cd18000 138 LDEGHKIRNPDAEITLACKQLRTPHRLILSGTPIQNNLKELWSLFDFVFP 187
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
378-867 |
5.66e-84 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 296.33 E-value: 5.66e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 378 PECIFRKLFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSLH-FSKMYKPSIIICPVTLLRQWRREAQKWY 456
Cdd:PLN03142 163 PSCIKGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHeYRGITGPHMVVAPKSTLGNWMNEIRRFC 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 457 PDFHVEILHDSAQDSGHGKGQGKASEsdydsessvdsdhepkskntkKWDsllnrvlnsesgLLITTYEQLRLQGEKLLN 536
Cdd:PLN03142 243 PVLRAVKFHGNPEERAHQREELLVAG---------------------KFD------------VCVTSFEMAIKEKTALKR 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 537 IEWGYAVLDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEFSVpitvGGYA 616
Cdd:PLN03142 290 FSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQI----SGEN 365
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 617 NasplQVSTAYRCAVVLRdlimPYLLRRMKADVNAHLTKKTEHVLFCSLTVEQRSTYRAFLaSSEVEQIFDG-NRNSLYG 695
Cdd:PLN03142 366 D----QQEVVQQLHKVLR----PFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKALL-QKDLDVVNAGgERKRLLN 436
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 696 IdVM--RKICNHPDLLerehshQNPDYGNP--------ERSGKMKVVAEVLKVWKQQGHRVLLFSQTQQMLDILESFLVA 765
Cdd:PLN03142 437 I-AMqlRKCCNHPYLF------QGAEPGPPyttgehlvENSGKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMY 509
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 766 NEYSYRRMDGLTPVKQRMALIDEFN--NSEDmFVFVLTTKVGGLGTNLTGANRVIIFDPDWNPSNDMQARERAWRIGQKK 843
Cdd:PLN03142 510 RGYQYCRIDGNTGGEDRDASIDAFNkpGSEK-FVFLLSTRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKK 588
|
490 500
....*....|....*....|....
gi 1063704106 844 DVTVYRLITRGTIEEKVYHRQiYK 867
Cdd:PLN03142 589 EVQVFRFCTEYTIEEKVIERA-YK 611
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
388-709 |
1.75e-83 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 273.79 E-value: 1.75e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 388 YQRVGVQWLWELHCQRA-GGIIGDEMGLGKTIQVLSFLGSL-HFSKMY-KPSIIICPVTLLRQWRREAQKW--YPDFHVE 462
Cdd:pfam00176 1 YQIEGVNWMLSLENNLGrGGILADEMGLGKTLQTISLLLYLkHVDKNWgGPTLIVVPLSLLHNWMNEFERWvsPPALRVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 463 ILHdsaqdsGHGKGQgkasesdydsessvdsdHEPKSKNTKKWDSllnrvlnsesGLLITTYEQLRLQGEKLLNIEWGYA 542
Cdd:pfam00176 81 VLH------GNKRPQ-----------------ERWKNDPNFLADF----------DVVITTYETLRKHKELLKKVHWHRI 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 543 VLDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEFSVPITVGGyanasplq 622
Cdd:pfam00176 128 VLDEGHRLKNSKSKLSKALKSLKTRNRWILTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERGG-------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 623 vstAYRCAVVLRDLIMPYLLRRMKADVNAHLTKKTEHVLFCSLTVEQRSTYRAFLASSEVEQIFDGN------RNSLYGI 696
Cdd:pfam00176 200 ---GKKGVSRLHKLLKPFLLRRTKKDVEKSLPPKVEYILFCRLSKLQRKLYQTFLLKKDLNAIKTGEggreikASLLNIL 276
|
330
....*....|...
gi 1063704106 697 DVMRKICNHPDLL 709
Cdd:pfam00176 277 MRLRKICNHPGLI 289
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
385-644 |
8.51e-65 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 219.17 E-value: 8.51e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 385 LFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSLHFSKMYKPSIIICPVTLLRQWRREAQKWYPDFHVEIL 464
Cdd:cd18001 1 LYPHQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSGMFDSGLIKSVLVVMPTSLIPHWVKEFAKWTPGLRVKVF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 465 HdsaqdsghgkgqgkasesdydsessvdsdhepkSKNTKKWDSLLNRVLNsESGLLITTYEQLR-----LQGEKLLNIEW 539
Cdd:cd18001 81 H---------------------------------GTSKKERERNLERIQR-GGGVLLTTYGMVLsnteqLSADDHDEFKW 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 540 GYAVLDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGK-LGVLPVFEAEFSVPITVGGYANA 618
Cdd:cd18001 127 DYVILDEGHKIKNSKTKSAKSLREIPAKNRIILTGTPIQNNLKELWALFDFACNGSlLGTRKTFKMEFENPITRGRDKDA 206
|
250 260
....*....|....*....|....*.
gi 1063704106 619 SPLQVSTAYRCAVVLRDLIMPYLLRR 644
Cdd:cd18001 207 TQGEKALGSEVAENLRQIIKPYFLRR 232
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
385-593 |
3.45e-63 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 212.43 E-value: 3.45e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 385 LFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSLHFS-KMYKPSIIICPVTLLRQWRREAQKWYPDFHVEI 463
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAYLLKEgKERGPVLVVCPLSVLENWEREFEKWTPDLRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 464 LHDSAQDSghgkgqgkasesdydsessvdsdhepKSKNTKKWDsllnrvlnSESGLLITTYEQLRLQGEKLLNIEWGYAV 543
Cdd:cd17919 81 YHGSQRER--------------------------AQIRAKEKL--------DKFDVVLTTYETLRRDKASLRKFRWDLVV 126
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1063704106 544 LDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFP 593
Cdd:cd17919 127 VDEAHRLKNPKSQLSKALKALRAKRRLLLTGTPLQNNLEELWALLDFLDP 176
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
726-851 |
3.70e-60 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 201.94 E-value: 3.70e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 726 SGKMKVVAEVLKVWKQQGHRVLLFSQTQQMLDILESFLVANEYSYRRMDGLTPVKQRMALIDEFNNSEDMFVFVLTTKVG 805
Cdd:cd18793 10 SGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKAG 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1063704106 806 GLGTNLTGANRVIIFDPDWNPSNDMQARERAWRIGQKKDVTVYRLI 851
Cdd:cd18793 90 GVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
385-646 |
4.76e-59 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 202.41 E-value: 4.76e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 385 LFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSLHFSKMYKPSIIICPVTLLRQWRREAQKWYPDFHVEIL 464
Cdd:cd18012 5 LRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALLLSRKEEGRKGPSLVVAPTSLIYNWEEEAAKFAPELKVLVI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 465 HDSaqdsghgkgqgkasesdydsessvdSDHEPKSKNTKKWDsllnrvlnsesgLLITTYEQLRLQGEKLLNIEWGYAVL 544
Cdd:cd18012 85 HGT-------------------------KRKREKLRALEDYD------------LVITSYGLLRRDIELLKEVKFHYLVL 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 545 DEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEFSVPITVGGYANASplqvs 624
Cdd:cd18012 128 DEAQNIKNPQTKTAKAVKALKADHRLALTGTPIENHLGELWSIFDFLNPGLLGSYKRFKKRFAKPIEKDGDEEAL----- 202
|
250 260
....*....|....*....|..
gi 1063704106 625 tayrcaVVLRDLIMPYLLRRMK 646
Cdd:cd18012 203 ------EELKKLISPFILRRLK 218
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
385-644 |
7.06e-53 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 185.66 E-value: 7.06e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 385 LFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSL---------------------HFSKMYKPSIIICPVT 443
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLAAVlgktgtrrdrennrprfkkkpPASSAKKPVLIVAPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 444 LLRQWRREAQKWyPDFHVEILHdsaqdsghgkGQGKAsesdydsessvdsdhepkskntkkwDSLLNRVLNSESGLLITT 523
Cdd:cd18005 81 VLYNWKDELDTW-GHFEVGVYH----------GSRKD-------------------------DELEGRLKAGRLEVVVTT 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 524 YEQLRLQGEKLLNIEWGYAVLDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFE 603
Cdd:cd18005 125 YDTLRRCIDSLNSINWSAVIADEAHRIKNPKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFK 204
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1063704106 604 AEFSVPITVGGYANASPLQVSTAYRCAVVLRDLIMPYLLRR 644
Cdd:cd18005 205 KHFSEPIKRGQRHTATARELRLGRKRKQELAVKLSKFFLRR 245
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
385-644 |
4.84e-51 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 179.85 E-value: 4.84e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 385 LFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSLHFSK------MYKPSIIICPVTLLRQWRREAQKWYPD 458
Cdd:cd17999 1 LRPYQQEGINWLAFLNKYNLHGILCDDMGLGKTLQTLCILASDHHKRansfnsENLPSLVVCPPTLVGHWVAEIKKYFPN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 459 FHVEILHDsaqdsgHGKGQGKASESdydsessvdsdHEPKSKNtkkwdsllnrvlnsesgLLITTYEQLRLQGEKLLNIE 538
Cdd:cd17999 81 AFLKPLAY------VGPPQERRRLR-----------EQGEKHN-----------------VIVASYDVLRNDIEVLTKIE 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 539 WGYAVLDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEFSVPITVGGYANA 618
Cdd:cd17999 127 WNYCVLDEGHIIKNSKTKLSKAVKQLKANHRLILSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRFLKPILASRDSKA 206
|
250 260
....*....|....*....|....*.
gi 1063704106 619 SPLQVSTAYRCAVVLRDLIMPYLLRR 644
Cdd:cd17999 207 SAKEQEAGALALEALHKQVLPFLLRR 232
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
385-644 |
3.11e-43 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 157.02 E-value: 3.11e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 385 LFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSL-HFSKMYKPSIIICPVTLLRQWRREAQKWyPDFHVEI 463
Cdd:cd17995 1 LRDYQLEGVNWLLFNWYNRRNCILADEMGLGKTIQSIAFLEHLyQVEGIRGPFLVIAPLSTIPNWQREFETW-TDMNVVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 464 LHDSAQDSGhgkgqgkasesdydsessVDSDHEPKSK-NTKKWDSllnRVLNSEsgLLITTYEQLRLQGEKLLNIEWGYA 542
Cdd:cd17995 80 YHGSGESRQ------------------IIQQYEMYFKdAQGRKKK---GVYKFD--VLITTYEMVIADAEELRKIPWRVV 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 543 VLDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEFsvpitvGGYANASplQ 622
Cdd:cd17995 137 VVDEAHRLKNRNSKLLQGLKKLTLEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEF------GDLKTAE--Q 208
|
250 260
....*....|....*....|..
gi 1063704106 623 VSTayrcavvLRDLIMPYLLRR 644
Cdd:cd17995 209 VEK-------LQALLKPYMLRR 223
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
389-644 |
3.29e-42 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 154.75 E-value: 3.29e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 389 QRVGVQWLWE-LHCQRAGGIIG----DEMGLGKTIQVLSFLGSLHFSKMYKPS-----IIICPVTLLRQWRREAQKWYPD 458
Cdd:cd18004 5 QREGVQFLYDcLTGRRGYGGGGailaDEMGLGKTLQAIALVWTLLKQGPYGKPtakkaLIVCPSSLVGNWKAEFDKWLGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 459 fhvEILHDSAQDSGHGKGQgkasesdydsessvdsdhepkskntkkwDSLLNRVLNSESGLLITTYEQLRLQGEKLLN-I 537
Cdd:cd18004 85 ---RRIKVVTADGNAKDVK----------------------------ASLDFFSSASTYPVLIISYETLRRHAEKLSKkI 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 538 EWGYAVLDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEFSVPITVGGYAN 617
Cdd:cd18004 134 SIDLLICDEGHRLKNSESKTTKALNSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPILRSRDPD 213
|
250 260
....*....|....*....|....*..
gi 1063704106 618 ASPLQVSTAYRCAVVLRDLIMPYLLRR 644
Cdd:cd18004 214 ASEEDKELGAERSQELSELTSRFILRR 240
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
384-646 |
1.88e-39 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 146.75 E-value: 1.88e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 384 KLFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSL-HFSKMYKPSIIICPVTLLRQWRREAQKWYPDFHVE 462
Cdd:cd17996 3 TLKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLITYLmEKKKNNGPYLVIVPLSTLSNWVSEFEKWAPSVSKI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 463 ILhdsaqdsghgKGqgkasesdydsessvdsdhepkSKNTKKwdSLLNRVLNSESGLLITTYEQLRLQGEKLLNIEWGYA 542
Cdd:cd17996 83 VY----------KG----------------------TPDVRK--KLQSQIRAGKFNVLLTTYEYIIKDKPLLSKIKWKYM 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 543 VLDEGHRIRNPNSDITLVCKQ-LQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEFSVPITVGGYANASPL 621
Cdd:cd17996 129 IIDEGHRMKNAQSKLTQTLNTyYHARYRLLLTGTPLQNNLPELWALLNFLLPKIFKSCKTFEQWFNTPFANTGEQVKIEL 208
|
250 260
....*....|....*....|....*....
gi 1063704106 622 ----QVSTAYRCAVVLRdlimPYLLRRMK 646
Cdd:cd17996 209 neeeTLLIIRRLHKVLR----PFLLRRLK 233
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
385-644 |
1.66e-38 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 143.65 E-value: 1.66e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 385 LFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSLHFSK-MYKPSIIICPVTLLRQWRREAQKWYPDFHVEI 463
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLACEKgNWGPHLIVVPTSVMLNWEMEFKRWCPGFKILT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 464 LHDSAQDSgHGKGQGKASEsdydsessvDSDHepkskntkkwdsllnrvlnsesgLLITTYeQLRLQGEKLLN-IEWGYA 542
Cdd:cd18003 81 YYGSAKER-KLKRQGWMKP---------NSFH-----------------------VCITSY-QLVVQDHQVFKrKKWKYL 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 543 VLDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEFSVPITVggyanasPLQ 622
Cdd:cd18003 127 ILDEAHNIKNFKSQRWQTLLNFNTQRRLLLTGTPLQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNPLTA-------MSE 199
|
250 260
....*....|....*....|....
gi 1063704106 623 VSTAYRCAVV--LRDLIMPYLLRR 644
Cdd:cd18003 200 GSQEENEELVrrLHKVLRPFLLRR 223
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
384-646 |
2.75e-38 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 142.85 E-value: 2.75e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 384 KLFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSL-HFSKMYKPSIIICPVTLLRQWRREAQKWYPDFHVE 462
Cdd:cd17997 3 TMRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLGYLkHYKNINGPHLIIVPKSTLDNWMREFKRWCPSLRVV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 463 ILHdsaqdsGHGKGQGKASESDYDsessvdsdhepksknTKKWDsllnrvlnsesgLLITTYEQLRLQGEKLLNIEWGYA 542
Cdd:cd17997 83 VLI------GDKEERADIIRDVLL---------------PGKFD------------VCITSYEMVIKEKTVLKKFNWRYI 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 543 VLDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEFSVpitvggyANASPLQ 622
Cdd:cd17997 130 IIDEAHRIKNEKSKLSQIVRLFNSRNRLLLTGTPLQNNLHELWALLNFLLPDVFTSSEDFDEWFNV-------NNCDDDN 202
|
250 260
....*....|....*....|....
gi 1063704106 623 VSTAYRCAVVLRdlimPYLLRRMK 646
Cdd:cd17997 203 QEVVQRLHKVLR----PFLLRRIK 222
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
388-646 |
8.88e-38 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 141.75 E-value: 8.88e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 388 YQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSLHFSKMYKPSIIICPVTLLRQWRREAQKWYPDFHVEILHDS 467
Cdd:cd18009 7 YQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLAHLRERGVWGPFLVIAPLSTLPNWVNEFARFTPSVPVLLYHGT 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 468 AQDSghgkgqgkasesdydsessvdsDHEPKSKNTKKWDSLLNRVLnsesgllITTYEQLRLQGEKLLNIEWGYAVLDEG 547
Cdd:cd18009 87 KEER----------------------ERLRKKIMKREGTLQDFPVV-------VTSYEIAMRDRKALQHYAWKYLIVDEG 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 548 HRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEFSVPITVGGYANASPLQVSTAY 627
Cdd:cd18009 138 HRLKNLNCRLIQELKTFNSDNRLLLTGTPLQNNLSELWSLLNFLLPDVFDDLSSFESWFDFSSLSDNAADISNLSEEREQ 217
|
250
....*....|....*....
gi 1063704106 628 RCAVVLRDLIMPYLLRRMK 646
Cdd:cd18009 218 NIVHMLHAILKPFLLRRLK 236
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
385-644 |
2.98e-36 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 137.80 E-value: 2.98e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 385 LFDYQRVGVQWLweLHCqraGGIIGDEMGLGKTIQVLS----------------FLGSLHFSKMYKPS--IIICPVTLLR 446
Cdd:cd18008 1 LLPYQKQGLAWM--LPR---GGILADEMGLGKTIQALAlilatrpqdpkipeelEENSSDPKKLYLSKttLIVVPLSLLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 447 QWRREAQK--WYPDFHVEILHDSaqdsghgkgqgkasesdydsessvdsdhePKSKNTKKWdsllnrvlnSESGLLITTY 524
Cdd:cd18008 76 QWKDEIEKhtKPGSLKVYVYHGS-----------------------------KRIKSIEEL---------SDYDIVITTY 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 525 EQLR----------------LQGEKLLNIEWGYAVLDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLF 588
Cdd:cd18008 118 GTLAsefpknkkgggrdskeKEASPLHRIRWYRVILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLL 197
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1063704106 589 DFVFPGKLGVLPVFEAEFSVPITVGGYANASPLQVstayrcavvlrdLIMPYLLRR 644
Cdd:cd18008 198 RFLRVEPFGDYPWFNSDISKPFSKNDRKALERLQA------------LLKPILLRR 241
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
389-623 |
4.34e-36 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 137.04 E-value: 4.34e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 389 QRVGVQWLWElHC-------QRAGG-IIGDEMGLGKTIQVLSFLGSL--HFSKMYKPsIIICPVTLLRQWRREAQKWYPD 458
Cdd:cd18007 5 QVEGVRFLWS-NLvgtdvgsDEGGGcILAHTMGLGKTLQVITFLHTYlaAAPRRSRP-LVLCPASTLYNWEDEFKKWLPP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 459 FHVeILHDSAQDSGHGKGQGKAsesdydsessvdsdhepksKNTKKWdsllnrvlNSESGLLITTYEQLR---LQGEKLL 535
Cdd:cd18007 83 DLR-PLLVLVSLSASKRADARL-------------------RKINKW--------HKEGGVLLIGYELFRnlaSNATTDP 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 536 NIEW-----------GYAVLDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEA 604
Cdd:cd18007 135 RLKQefiaalldpgpDLLVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKK 214
|
250
....*....|....*....
gi 1063704106 605 EFSVPITVGGYANASPLQV 623
Cdd:cd18007 215 KFVKPIEAGQCVDSTEEDV 233
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
384-605 |
8.16e-36 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 135.56 E-value: 8.16e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 384 KLFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSL-HFSKMYKPSIIICPVTLLRQWRREAQKWYPDFHVe 462
Cdd:cd17993 1 ELRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLSYLfHSQQQYGPFLVVVPLSTMPAWQREFAKWAPDMNV- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 463 ILHDSAQDSghgkgqgkasesdydseSSVDSDHE---PKSKNTKkwdslLNrvlnsesgLLITTYEQLRLQGEKLLNIEW 539
Cdd:cd17993 80 IVYLGDIKS-----------------RDTIREYEfyfSQTKKLK-----FN--------VLLTTYEIILKDKAFLGSIKW 129
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063704106 540 GYAVLDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAE 605
Cdd:cd17993 130 QYLAVDEAHRLKNDESLLYEALKEFKTNNRLLITGTPLQNSLKELWALLHFLMPGKFDIWEEFEEE 195
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
384-644 |
1.42e-34 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 132.82 E-value: 1.42e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 384 KLFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSL-HFSKMYKPSIIICPVTLLRQWRREAQKWYPDFHVE 462
Cdd:cd18054 20 ELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLfHQHQLYGPFLLVVPLSTLTSWQREFEIWAPEINVV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 463 ILHDSAQdsghgkgqgkasesdydsessvdsdhepkSKNT-KKWDSLLNRVLNSESGLLITTYEQLRLQGEKLLNIEWGY 541
Cdd:cd18054 100 VYIGDLM-----------------------------SRNTiREYEWIHSQTKRLKFNALITTYEILLKDKTVLGSINWAF 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 542 AVLDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEFSvpitvGGYANaspl 621
Cdd:cd18054 151 LGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHG-----KGREN---- 221
|
250 260
....*....|....*....|...
gi 1063704106 622 qvstAYRCavvLRDLIMPYLLRR 644
Cdd:cd18054 222 ----GYQS---LHKVLEPFLLRR 237
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
388-644 |
7.07e-34 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 129.87 E-value: 7.07e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 388 YQRVGVQWLWE-LHCQRaGGIIGDEMGLGKTIQVLSFLGSLHFS-KMYKPSIIICPVTLLRQWRREAQKWYPDFHV---- 461
Cdd:cd18006 4 YQLEGVNWLLQcRAEQH-GCILGDEMGLGKTCQTISLLWYLAGRlKLLGPFLVLCPLSVLDNWKEELNRFAPDLSVitym 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 462 ---EILHDSAQDSghgkgqgkasesdydsessvdsdhepksKNTKKWDSLLnrvlnsesglliTTYEQLRLQGEKLLNIE 538
Cdd:cd18006 83 gdkEKRLDLQQDI----------------------------KSTNRFHVLL------------TTYEICLKDASFLKSFP 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 539 WGYAVLDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGvlpvfeaefsvPITVGGYANA 618
Cdd:cd18006 123 WASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLLTGTPIQNSLQELYALLSFIEPNVFP-----------KDKLDDFIKA 191
|
250 260
....*....|....*....|....*.
gi 1063704106 619 SPlQVSTAYRCAVVLRDLIMPYLLRR 644
Cdd:cd18006 192 YS-ETDDESETVEELHLLLQPFLLRR 216
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
384-656 |
3.05e-33 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 129.02 E-value: 3.05e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 384 KLFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSL-HFSKMYKPSIIICPVTLLRQWRREAQKWYPDFH-V 461
Cdd:cd18064 15 KLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMkHYRNIPGPHMVLVPKSTLHNWMAEFKRWVPTLRaV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 462 EILHDSAQDSGHGKgqgkasesdydsessvdsdhepkskntkkwdsllNRVLNSESGLLITTYEQLRLQGEKLLNIEWGY 541
Cdd:cd18064 95 CLIGDKDQRAAFVR----------------------------------DVLLPGEWDVCVTSYEMLIKEKSVFKKFNWRY 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 542 AVLDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEFSVPITVGgyanaspl 621
Cdd:cd18064 141 LVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDSWFDTNNCLG-------- 212
|
250 260 270
....*....|....*....|....*....|....*
gi 1063704106 622 QVSTAYRCAVVLRdlimPYLLRRMKADVNAHLTKK 656
Cdd:cd18064 213 DQKLVERLHMVLR----PFLLRRIKADVEKSLPPK 243
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
388-644 |
1.11e-32 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 127.27 E-value: 1.11e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 388 YQRVGVQWLWEL-----HCQRAGGIIGDEMGLGKTIQVLSFLGSLHFSKMY--KP----SIIICPVTLLRQWRREAQKWY 456
Cdd:cd18066 4 HQREGIEFLYECvmgmrVNERFGAILADEMGLGKTLQCISLIWTLLRQGPYggKPvikrALIVTPGSLVKNWKKEFQKWL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 457 PDFHVEILhdsaqdsghgkgqgkasesdydsesSVDSDHepkskntkKWDSLLNRVLNSesgLLITTYEQLRLQGEKLLN 536
Cdd:cd18066 84 GSERIKVF-------------------------TVDQDH--------KVEEFIASPLYS---VLIISYEMLLRSLDQISK 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 537 IEWGYAVLDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEFSVPITVGGYA 616
Cdd:cd18066 128 LNFDLVICDEGHRLKNTSIKTTTALTSLSCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVYEEPIVRSREP 207
|
250 260
....*....|....*....|....*...
gi 1063704106 617 NASPLQVSTAYRCAVVLRDLIMPYLLRR 644
Cdd:cd18066 208 TATPEEKKLGEARAAELTRLTGLFILRR 235
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
385-593 |
3.17e-32 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 124.03 E-value: 3.17e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 385 LFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSLHFSKMYKPSIIICPVTLLRQWRREAQKWYPDFHVEIL 464
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLAYLKEIGIPGPHLVVVPSSTLDNWLREFKRWCPSLKVEPY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 465 HDSAQDSGHGKGQGKasesdydsessvdsdhepksKNTKKWDsllnrvlnsesgLLITTYEQLRLQGE--KLL-NIEWGY 541
Cdd:cd17998 81 YGSQEERKHLRYDIL--------------------KGLEDFD------------VIVTTYNLATSNPDdrSFFkRLKLNY 128
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1063704106 542 AVLDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFP 593
Cdd:cd17998 129 VVYDEGHMLKNMTSERYRHLMTINANFRLLLTGTPLQNNLLELMSLLNFIMP 180
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
384-605 |
4.70e-30 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 119.77 E-value: 4.70e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 384 KLFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSL-HFSKMYKPSIIICPVTLLRQWRREAQKWYPDFHVE 462
Cdd:cd18053 20 ELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLfHEHQLYGPFLLVVPLSTLTSWQREIQTWAPQMNAV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 463 I-LHDsaqdsghgkgqgkasesdyDSESSVDSDHEPKSKNTKKWdsllnrvlnsESGLLITTYEQLRLQGEKLLNIEWGY 541
Cdd:cd18053 100 VyLGD-------------------INSRNMIRTHEWMHPQTKRL----------KFNILLTTYEILLKDKSFLGGLNWAF 150
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063704106 542 AVLDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAE 605
Cdd:cd18053 151 IGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEE 214
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
388-646 |
5.16e-29 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 117.09 E-value: 5.16e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 388 YQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSL-HFSKMYKPSIIICPVTLLRQWRREAQKWYPDFhVEILHd 466
Cdd:cd18063 27 YQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLmEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSV-VKISY- 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 467 saqdsghgKGQgkasesdydsessvdsdhePKSKNtkkwdSLLNRVLNSESGLLITTYEQLRLQGEKLLNIEWGYAVLDE 546
Cdd:cd18063 105 --------KGT-------------------PAMRR-----SLVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 547 GHRIRNPNSDITLVCKQLQTV-HRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEFSVPITVGGyaNASPLQVST 625
Cdd:cd18063 153 GHRMKNHHCKLTQVLNTHYVApRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTG--ERVDLNEEE 230
|
250 260
....*....|....*....|.
gi 1063704106 626 AYRCAVVLRDLIMPYLLRRMK 646
Cdd:cd18063 231 TILIIRRLHKVLRPFLLRRLK 251
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
405-628 |
9.76e-29 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 115.68 E-value: 9.76e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 405 GGIIGDEMGLGKTIQVLSFLGSLHFSKMYKPSIIICPVTLLRQWRREAQKWYP-----------DFHVEILHDSAQDSgh 473
Cdd:cd18069 30 GCILAHSMGLGKTLQVISFLDVLLRHTGAKTVLAIVPVNTLQNWLSEFNKWLPppealpnvrprPFKVFILNDEHKTT-- 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 474 gkgqgkasesdydsessvdsdhEPKSKNTKKWDSllnrvlnsESGLLITTYEQLRLQ-GEKLLniewgyaVLDEGHRIRN 552
Cdd:cd18069 108 ----------------------AARAKVIEDWVK--------DGGVLLMGYEMFRLRpGPDVV-------ICDEGHRIKN 150
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063704106 553 PNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEFSVPITVGGYANASPLQVSTA-YR 628
Cdd:cd18069 151 CHASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCVDSTPQDVKLMrYR 227
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
385-646 |
1.07e-28 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 116.30 E-value: 1.07e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 385 LFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSL-HFSKMYKPSIIICPVTLLRQWRREAQKWYPDFhvei 463
Cdd:cd18062 24 LKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLmEHKRINGPFLIIVPLSTLSNWVYEFDKWAPSV---- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 464 lhdsaqdsghgkgqgkasesdydseSSVDSDHEPKSKNtkkwdSLLNRVLNSESGLLITTYEQLRLQGEKLLNIEWGYAV 543
Cdd:cd18062 100 -------------------------VKVSYKGSPAARR-----AFVPQLRSGKFNVLLTTYEYIIKDKQILAKIRWKYMI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 544 LDEGHRIRNPNSDITLVCK-QLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEFSVPITVGGyaNASPLQ 622
Cdd:cd18062 150 VDEGHRMKNHHCKLTQVLNtHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTG--EKVDLN 227
|
250 260
....*....|....*....|....
gi 1063704106 623 VSTAYRCAVVLRDLIMPYLLRRMK 646
Cdd:cd18062 228 EEETILIIRRLHKVLRPFLLRRLK 251
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
388-644 |
1.82e-28 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 115.26 E-value: 1.82e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 388 YQRVGVQWLWELHCQRA-----GGIIGDEMGLGKTIQVLSFLGSL-HFSKMYKPSI----IICPVTLLRQWRREAQKWyp 457
Cdd:cd18067 4 HQREGVKFLYRCVTGRRirgshGCIMADEMGLGKTLQCITLMWTLlRQSPQCKPEIdkaiVVSPSSLVKNWANELGKW-- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 458 dfhveiLHDSAQDSGHGKGQGKASESdydsessvdsdhepkskNTKKWDSLLNRVLNSEsgLLITTYEQLRLQGEKLLNI 537
Cdd:cd18067 82 ------LGGRLQPLAIDGGSKKEIDR-----------------KLVQWASQQGRRVSTP--VLIISYETFRLHVEVLQKG 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 538 EWGYAVLDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEFSVPITVGGYAN 617
Cdd:cd18067 137 EVGLVICDEGHRLKNSDNQTYQALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPILKGRDAD 216
|
250 260
....*....|....*....|....*..
gi 1063704106 618 ASPLQVSTAYRCAVVLRDLIMPYLLRR 644
Cdd:cd18067 217 ASEKERQLGEEKLQELISIVNRCIIRR 243
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
727-840 |
5.58e-28 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 109.22 E-value: 5.58e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 727 GKMKVVAEVLKvwKQQGHRVLLFSQTQQMLDIlESFLVANEYSYRRMDGLTPVKQRMALIDEFNNSEdmFVFVLTTKVGG 806
Cdd:pfam00271 1 EKLEALLELLK--KERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGK--IDVLVATDVAE 75
|
90 100 110
....*....|....*....|....*....|....
gi 1063704106 807 LGTNLTGANRVIIFDPDWNPSNDMQARERAWRIG 840
Cdd:pfam00271 76 RGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
385-646 |
2.48e-27 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 111.65 E-value: 2.48e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 385 LFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSL-HFSKMYKPSIIICPVTLLRQWRREAQKWYPDFHVEI 463
Cdd:cd18065 16 LRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLkHYRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRAVC 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 464 LHdsaqdsghGKGQGKASEsdydsessvdsdhepkskntkkwdsLLNRVLNSESGLLITTYEQLRLQGEKLLNIEWGYAV 543
Cdd:cd18065 96 LI--------GDKDARAAF-------------------------IRDVMMPGEWDVCVTSYEMVIKEKSVFKKFNWRYLV 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 544 LDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEFSVPITVGgyanasplQV 623
Cdd:cd18065 143 IDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWFDTKNCLG--------DQ 214
|
250 260
....*....|....*....|...
gi 1063704106 624 STAYRCAVVLRdlimPYLLRRMK 646
Cdd:cd18065 215 KLVERLHAVLK----PFLLRRIK 233
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
385-644 |
3.28e-27 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 110.22 E-value: 3.28e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 385 LFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSLHFSKMYK-PSIIICPVTLLRQWRREAQKWYPDFHVEI 463
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHSKgPFLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 464 LHdsaqdsghgkgqgkasesdydsessvdSDHepkskntkkwdsllnrvlnsesgLLITTYEQLRLQGEKLLNIEWGYAV 543
Cdd:cd17994 81 YV---------------------------GDH-----------------------VLLTSYELISIDQAILGSIDWAVLV 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 544 LDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEFSVPitvggyanASPLQV 623
Cdd:cd17994 111 VDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLQGFLEEFADI--------SKEDQI 182
|
250 260
....*....|....*....|.
gi 1063704106 624 STayrcavvLRDLIMPYLLRR 644
Cdd:cd17994 183 KK-------LHDLLGPHMLRR 196
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
385-644 |
7.57e-27 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 110.29 E-value: 7.57e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 385 LFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSLHFSK-MYKPSIIICPVTLLRQWRREAQKWYPDFHVEI 463
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLAHLAEEHnIWGPFLVIAPASTLHNWQQEISRFVPQFKVLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 464 LHDSAQDsghgkgqgkasesdydsessvdsdhepKSKNTKKWDSLLNRVLNSESGLLITTYeQLRLQGEKLLN-IEWGYA 542
Cdd:cd18002 81 YWGNPKD---------------------------RKVLRKFWDRKNLYTRDAPFHVVITSY-QLVVQDEKYFQrVKWQYM 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 543 VLDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEFSVPIT--VGGYANASP 620
Cdd:cd18002 133 VLDEAQAIKSSSSSRWKTLLSFHCRNRLLLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIEshAENKTGLNE 212
|
250 260
....*....|....*....|....
gi 1063704106 621 LQVStayRCAVVLRdlimPYLLRR 644
Cdd:cd18002 213 HQLK---RLHMILK----PFMLRR 229
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
388-644 |
1.20e-24 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 103.94 E-value: 1.20e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 388 YQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSLHFSKMYK-PSIIICPVTLLRQWRREAQKWYPDFHVeILHD 466
Cdd:cd18055 4 YQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTKgPFLVSAPLSTIINWEREFQMWAPDFYV-VTYT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 467 SAQDSghgkgqgkaSESDYDSESSVDSDHEPKSKNTKKwdslLNRVLNSESGLLITTYEQLRLQGEKLLNIEWGYAVLDE 546
Cdd:cd18055 83 GDKDS---------RAIIRENEFSFDDNAVKGGKKAFK----MKREAQVKFHVLLTSYELVTIDQAALGSIRWACLVVDE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 547 GHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEFSvpitvggyanasplQVSTA 626
Cdd:cd18055 150 AHRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFA--------------DISKE 215
|
250
....*....|....*...
gi 1063704106 627 YRCAvVLRDLIMPYLLRR 644
Cdd:cd18055 216 DQIK-KLHDLLGPHMLRR 232
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
385-606 |
1.43e-24 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 103.20 E-value: 1.43e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 385 LFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSLHFSKMYKPSIIICPVTLLRQWRREAQKWyPDFHVEIL 464
Cdd:cd18058 1 LREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLSEIFLMGIRGPFLIIAPLSTITNWEREFRTW-TEMNAIVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 465 HDSaqdsghgkgQGKASESDYDSESSVDSDHEPKSKNTKkwdsllnrvlnseSGLLITTYEQLRLQGEKLLNIEWGYAVL 544
Cdd:cd18058 80 HGS---------QISRQMIQQYEMYYRDEQGNPLSGIFK-------------FQVVITTFEMILADCPELKKINWSCVII 137
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063704106 545 DEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEF 606
Cdd:cd18058 138 DEAHRLKNRNCKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEF 199
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
385-606 |
2.81e-24 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 102.44 E-value: 2.81e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 385 LFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSLHFSKMYKPSIIICPVTLLRQWRREAQKWyPDFHVEIL 464
Cdd:cd18060 1 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVYNVGIHGPFLVIAPLSTITNWEREFNTW-TEMNTIVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 465 HDSaqdsghgkgqgkasesdyDSESSVDSDHEPKSKNTK--------KWDSLlnrvlnsesgllITTYEQLRLQGEKLLN 536
Cdd:cd18060 80 HGS------------------LASRQMIQQYEMYCKDSRgrlipgayKFDAL------------ITTFEMILSDCPELRE 129
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 537 IEWGYAVLDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVlpvfEAEF 606
Cdd:cd18060 130 IEWRCVIIDEAHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPS----ESEF 195
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
385-606 |
3.42e-24 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 102.42 E-value: 3.42e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 385 LFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSLHFSKMYKPSIIICPVTLLRQWRREAQKWyPDFHVEIL 464
Cdd:cd18059 1 LREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFLVIAPLSTIPNWEREFRTW-TELNVVVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 465 HDSaqdsghgkgqgKASESDYDSESSVDSDHEPKS-KNTKKWDSLlnrvlnsesgllITTYEQLRLQGEKLLNIEWGYAV 543
Cdd:cd18059 80 HGS-----------QASRRTIQLYEMYFKDPQGRViKGSYKFHAI------------ITTFEMILTDCPELRNIPWRCVV 136
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063704106 544 LDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEF 606
Cdd:cd18059 137 IDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEF 199
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
385-644 |
8.40e-24 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 101.29 E-value: 8.40e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 385 LFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSLHFSKMYK-PSIIICPVTLLRQWRREAQKWYPDFHVeI 463
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKgPYLVSAPLSTIINWEREFEMWAPDFYV-V 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 464 LHDSAQDSghgkgqgkasesdYDSESSVDSDHEPKSKNTKKWDSLLNRVLNSESGLLITTYEQLRLQGEKLLNIEWGYAV 543
Cdd:cd18057 80 TYTGDKES-------------RSVIRENEFSFEDNAIRSGKKVFRMKKEAQIKFHVLLTSYELITIDQAILGSIEWACLV 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 544 LDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEFSvpitvggyanasplQV 623
Cdd:cd18057 147 VDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFA--------------DI 212
|
250 260
....*....|....*....|.
gi 1063704106 624 STAYRCAvVLRDLIMPYLLRR 644
Cdd:cd18057 213 SKEDQIK-KLHDLLGPHMLRR 232
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
388-624 |
3.79e-23 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 99.96 E-value: 3.79e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 388 YQRVGVQWLWELHCQR---------AGGIIGDEMGLGKTIQVLSFLGSLHFSKM---YKPSIIICPVTLLRQWRREAQKW 455
Cdd:cd18068 4 HQVDGVQFMWDCCCESlkktkkspgSGCILAHCMGLGKTLQVVTFLHTVLLCEKlenFSRVLVVCPLNTVLNWLNEFEKW 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 456 YPDfhveilhdsaqdsghgkgqgkASESDYDSESSVDSDHEPKSKNTKKWDSllnrvlNSESGLLITTYEQLR-LQGEK- 533
Cdd:cd18068 84 QEG---------------------LKDEEKIEVNELATYKRPQERSYKLQRW------QEEGGVMIIGYDMYRiLAQERn 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 534 --------------LLNIEWGYAVLDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVL 599
Cdd:cd18068 137 vksreklkeifnkaLVDPGPDFVVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTI 216
|
250 260
....*....|....*....|....*
gi 1063704106 600 PVFEAEFSVPITVGGYANASPLQVS 624
Cdd:cd18068 217 KEFRNRFVNPIQNGQCADSTLVDVR 241
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
385-644 |
4.52e-23 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 99.37 E-value: 4.52e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 385 LFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSLHFSKMYK-PSIIICPVTLLRQWRREAQKWYPDFHVeI 463
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKgPFLVSAPLSTIINWEREFEMWAPDMYV-V 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 464 LHDSAQDSghgkgqgkasesdYDSESSVDSDHEPKSKNTKKWDSLLNRVLNSESGLLITTYEQLRLQGEKLLNIEWGYAV 543
Cdd:cd18056 80 TYVGDKDS-------------RAIIRENEFSFEDNAIRGGKKASRMKKEASVKFHVLLTSYELITIDMAILGSIDWACLI 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 544 LDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEFSvpitvggyANASPLQV 623
Cdd:cd18056 147 VDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFA--------DIAKEDQI 218
|
250 260
....*....|....*....|.
gi 1063704106 624 STayrcavvLRDLIMPYLLRR 644
Cdd:cd18056 219 KK-------LHDMLGPHMLRR 232
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
757-840 |
7.40e-22 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 90.73 E-value: 7.40e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 757 DILESFLVANEYSYRRMDGLTPVKQRMALIDEFNNSEdmFVFVLTTKVGGLGTNLTGANRVIIFDPDWNPSNDMQARERA 836
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGK--IKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78
|
....
gi 1063704106 837 WRIG 840
Cdd:smart00490 79 GRAG 82
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
377-601 |
8.48e-22 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 94.48 E-value: 8.48e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 377 IPECIFRKLFDYQRVGVQWLWELHCqraGGIIGDEMGLGKTIQVLSFLGSLHFSKMYKPSIIICP-VTLLRQWRREAQKW 455
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGLR---DVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPtRELAEQWAEELKKL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 456 YPDFHVEILhdsaqdsghgkgqgkasesdydsesSVDSDHEPKSKntkkwdslLNRVLNSESGLLITTYEQLR--LQGEK 533
Cdd:smart00487 78 GPSLGLKVV-------------------------GLYGGDSKREQ--------LRKLESGKTDILVTTPGRLLdlLENDK 124
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063704106 534 LLNIEWGYAVLDEGHRIRNPN--SDITLVCKQL-QTVHRIIMTGAP---IQNKLTELWSLFDFVFPGKLGVLPV 601
Cdd:smart00487 125 LSLSNVDLVILDEAHRLLDGGfgDQLEKLLKLLpKNVQLLLLSATPpeeIENLLELFLNDPVFIDVGFTPLEPI 198
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
405-623 |
1.48e-21 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 95.23 E-value: 1.48e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 405 GGIIGDEMGLGKTIQVLSFLgslhfskMYKPSIIICPVTLLRQWRREAQKWYPDFHVEILhdsaqdSGHGKGQGKasesd 484
Cdd:cd18071 50 GGILADDMGLGKTLTTISLI-------LANFTLIVCPLSVLSNWETQFEEHVKPGQLKVY------TYHGGERNR----- 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 485 ydsessvdsdhEPKskntkkwdsllnrvLNSESGLLITTYEQLRLQ-----GEKLLNIEWGYAVLDEGHRIRNPNSDITL 559
Cdd:cd18071 112 -----------DPK--------------LLSKYDIVLTTYNTLASDfgakgDSPLHTINWLRVVLDEGHQIRNPNAQQTK 166
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063704106 560 VCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEFSVPITVGGYANASPLQV 623
Cdd:cd18071 167 AVLNLSSERRWVLTGTPIQNSPKDLGSLLSFLHLKPFSNPEYWRRLIQRPLTMGDPTGLKRLQV 230
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
385-606 |
1.52e-21 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 94.69 E-value: 1.52e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 385 LFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSLHFSKMYKPSIIICPVTLLRQWRREAQKWyPDFHVEIL 464
Cdd:cd18061 1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYEILLTGIRGPFLIIAPLSTIANWEREFRTW-TDLNVVVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 465 HDSAqdsghgkgqgkasesdydSESSVDSDHEPKSKNTKkwdsllNRVLNSESGL--LITTYEQLRLQGEKLLNIEWGYA 542
Cdd:cd18061 80 HGSL------------------ISRQMIQQYEMYFRDSQ------GRIIRGAYRFqaIITTFEMILGGCPELNAIDWRCV 135
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063704106 543 VLDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEF 606
Cdd:cd18061 136 IIDEAHRLKNKNCKLLEGLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEF 199
|
|
| CSB_WHD |
cd22254 |
winged-helix domain (WHD) found in cockayne syndrome group B (CSB) and similar proteins; CSB, ... |
1120-1186 |
1.50e-19 |
|
winged-helix domain (WHD) found in cockayne syndrome group B (CSB) and similar proteins; CSB, also called cockayne syndrome protein CSB, DNA excision repair protein ERCC-6, ERCC Excision Repair 6, or ATP-dependent helicase ERCC6, is involved in many DNA repair processes and is essential for transcription-coupled repair (TCR). It regulates DNA double-strand break (DSB) repair and checkpoint activation. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for TCR complex formation. CSB also regulates transcription and chromatin remodeling activities that are essential for neuronal differentiation and neuritogenesis. This model corresponds to the winged-helix domain (WHD) of CSB, which is involved in the recruitment of CSB to DSBs. The CSB WHD folds as a single globular domain, defining a class of ubiquitin-binding domains (UBDs) different from other UBD classes.
Pssm-ID: 439329 Cd Length: 72 Bit Score: 83.72 E-value: 1.50e-19
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063704106 1120 QPEVLIRKICSFV-QQKGGSADTTSIVNHFRDIVSFNDKQLFKNLLKEIATLEKDQN-RSFWVLKSEYK 1186
Cdd:cd22254 4 EAEELLADIRDFLaFQAGGQATTDEIVDHFKDRLPPEQSALFKALLKQICTFERDPGgRGVWVLKPEFR 72
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
385-597 |
1.83e-18 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 85.33 E-value: 1.83e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 385 LFDYQRVGVQWLWElHCQRAggIIGDEMGLGKTIQVlsfLGSLHFSKMYKPSIIICPVTLLRQWRREAQKWYPDFHVEIL 464
Cdd:cd18010 1 LLPFQREGVCFALR-RGGRV--LIADEMGLGKTVQA---IAIAAYYREEWPLLIVCPSSLRLTWADEIERWLPSLPPDDI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 465 H--DSAQDSGhgkgqgkasesdydsessvdSDHEPKskntkkwdsllnrvlnsesgLLITTYEQLRLQGEKLLNIEWGYA 542
Cdd:cd18010 75 QviVKSKDGL--------------------RDGDAK--------------------VVIVSYDLLRRLEKQLLARKFKVV 114
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1063704106 543 VLDEGHRIRNPNSDITLVCKQL--QTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLG 597
Cdd:cd18010 115 ICDESHYLKNSKAKRTKAALPLlkRAKRVILLSGTPALSRPIELFTQLDALDPKLFG 171
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
385-591 |
7.42e-16 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 78.29 E-value: 7.42e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 385 LFDYQRVGVQWL-WELHCQRAGGIIGDEMGLGKTIQVLSFL--------------------GSLHFSKMYKPS---IIIC 440
Cdd:cd18072 1 LLLHQKQALAWLlWRERQKPRGGILADDMGLGKTLTMIALIlaqkntqnrkeeekekalteWESKKDSTLVPSagtLVVC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 441 PVTLLRQWRREAQKWYPDFHVEILhdsaqdSGHGkgqgkasesdydsessvdSDHEPKSKNTKKWDsllnrvlnsesgLL 520
Cdd:cd18072 81 PASLVHQWKNEVESRVASNKLRVC------LYHG------------------PNRERIGEVLRDYD------------IV 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 521 ITTY----EQLRLQGEK-----LLNIEWGYAVLDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFV 591
Cdd:cd18072 125 ITTYslvaKEIPTYKEEsrsspLFRIAWARIILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFL 204
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
385-601 |
1.62e-15 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 77.77 E-value: 1.62e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 385 LFDYQRVGVQWLWElhcqrAGGIIGDEMGLGKTIQVLSFL------------GSLHFSKMY--------------KPSII 438
Cdd:cd18070 1 LLPYQRRAVNWMLV-----PGGILADEMGLGKTVEVLALIllhprpdndldaADDDSDEMVccpdclvaetpvssKATLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 439 ICPVTLLRQWRREAQKWYPDfHVEILHDSAQDSghgkgqgkasesdydseSSVDSDHEPKskntkkwdsllnRVLNSEsg 518
Cdd:cd18070 76 VCPSAILAQWLDEINRHVPS-SLKVLTYQGVKK-----------------DGALASPAPE------------ILAEYD-- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 519 LLITTYEQLR--------------LQGEK--------LLNIEWGYAVLDEGHRIRNPNSDITLVCKQLQTVHRIIMTGAP 576
Cdd:cd18070 124 IVVTTYDVLRtelhyaeanrsnrrRRRQKryeappspLVLVEWWRVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTP 203
|
250 260
....*....|....*....|....*
gi 1063704106 577 IQNKLTELWSLFDFvfpgkLGVLPV 601
Cdd:cd18070 204 IQRGLDDLFGLLSF-----LGVEPF 223
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
385-587 |
3.35e-12 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 66.93 E-value: 3.35e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 385 LFDYQRVGVqwLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSLHFSKMYKPSIIICPVTLLRQWRREAQKwypDFHVEIL 464
Cdd:cd18011 1 PLPHQIDAV--LRALRKPPVRLLLADEVGLGKTIEAGLIIKELLLRGDAKRVLILCPASLVEQWQDELQD---KFGLPFL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 465 hdsaqdsghgkgqgkasesdydsesSVDSDHEPKSKNtkkwdslLNRVLNSESGLLITTYEQLRLQGE---KLLNIEWGY 541
Cdd:cd18011 76 -------------------------ILDRETAAQLRR-------LIGNPFEEFPIVIVSLDLLKRSEErrgLLLSEEWDL 123
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1063704106 542 AVLDEGHRIRN-----PNSDITLvCKQL--QTVHRIIMTGAPIQNKLTELWSL 587
Cdd:cd18011 124 VVVDEAHKLRNsgggkETKRYKL-GRLLakRARHVLLLTATPHNGKEEDFRAL 175
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
385-597 |
1.55e-11 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 65.06 E-value: 1.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 385 LFDYQRVGVQWLWElhcQRAGGIIGDeMGLGKTIQVLSFLGSLHFSKMYKPSIIICPVTLLRQ-WRREAQKWypdfhvEI 463
Cdd:cd18013 1 PHPYQKVAINFIIE---HPYCGLFLD-MGLGKTVTTLTALSDLQLDDFTRRVLVIAPLRVARStWPDEVEKW------NH 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 464 LHDSAQDSGHGKGqgkasesdydsessvdsdhepkskntkkwdSLLNRVLNSESGLLITTYEQLR-LQGEKLLNIEWGYA 542
Cdd:cd18013 71 LRNLTVSVAVGTE------------------------------RQRSKAANTPADLYVINRENLKwLVNKSGDPWPFDMV 120
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1063704106 543 VLDEGHRIRNPNSDITLVCKQLQ-TVHRII-MTGAPIQNKLTELWSLFDFVFPGK-LG 597
Cdd:cd18013 121 VIDELSSFKSPRSKRFKALRKVRpVIKRLIgLTGTPSPNGLMDLWAQIALLDQGErLG 178
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
728-973 |
2.72e-08 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 58.20 E-value: 2.72e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 728 KMKVVAEVLK--VWKQQGHRVLLFSQTQQMLDILESFLVANEYSYRRM---------DGLTPvKQRMALIDEFNNSEdmF 796
Cdd:COG1111 336 KLSKLREILKeqLGTNPDSRIIVFTQYRDTAEMIVEFLSEPGIKAGRFvgqaskegdKGLTQ-KEQIEILERFRAGE--F 412
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 797 VFVLTTKVGGLGTNLTGANRVIIFDPDWNPSNDMQARERAWRIGQKKdvtVYRLITRGTIEEKVYHRQIYKHFLTNKILK 876
Cdd:COG1111 413 NVLVATSVAEEGLDIPEVDLVIFYEPVPSEIRSIQRKGRTGRKREGR---VVVLIAKGTRDEAYYWSSRRKEKKMKSILK 489
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704106 877 NpqQRRFFKARDMKDLFI-----LKDDGDSNASTETSNIFSQLAEEINIVGVQSDKKPESDTQLALHKTAEGSSEQTDVE 951
Cdd:COG1111 490 K--LKKLLDKQEKEKLKEsaqatLDEFESIKELAEDEINEKDLDEIESSENGAHVDWREPVLLQVIVSTLAESLELRELG 567
|
250 260
....*....|....*....|..
gi 1063704106 952 MTDKTGEAMDEETNILKSLFDA 973
Cdd:COG1111 568 EKVDDEVNLILEIDRVDVVDDG 589
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
786-848 |
1.18e-05 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 44.62 E-value: 1.18e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063704106 786 IDEFNNSEDMFVFVLTTKVGGLGTNLTGANRVIIFDPDWNPSNDMQARERAWRIGQKKDVTVY 848
Cdd:cd18785 13 IEHAEEIASSLEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEGEVIL 75
|
|
| |
