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Conserved domains on  [gi|1063705226|ref|NP_001325269|]
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Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11468027)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 424-519 2.92e-12

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 63.87  E-value: 2.92e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705226 424 YQTELSQEPNNPLLLANYAQfLYLVSNDHDRAEEYFKRAVGVEPKDAEAFSKYATFLWRARDDLwAAEETFLEAIDADPT 503
Cdd:COG4235     6 LRQALAANPNDAEGWLLLGR-AYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTE-EAEELLERALALDPD 83

                          90
                  ....*....|....*.
gi 1063705226 504 NSYYAANYANFLWNTG 519
Cdd:COG4235    84 NPEALYLLGLAAFQQG 99
 
Name Accession Description Interval E-value
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 424-519 2.92e-12

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 63.87  E-value: 2.92e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705226 424 YQTELSQEPNNPLLLANYAQfLYLVSNDHDRAEEYFKRAVGVEPKDAEAFSKYATFLWRARDDLwAAEETFLEAIDADPT 503
Cdd:COG4235     6 LRQALAANPNDAEGWLLLGR-AYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTE-EAEELLERALALDPD 83

                          90
                  ....*....|....*.
gi 1063705226 504 NSYYAANYANFLWNTG 519
Cdd:COG4235    84 NPEALYLLGLAAFQQG 99
TPR_19 pfam14559
Tetratricopeptide repeat;
449-513 9.16e-05

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 40.65  E-value: 9.16e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063705226 449 SNDHDRAEEYFKRAVGVEPKDAEAFSKYATFLWRArDDLWAAEETFLEAIDADPTNSYYAANYAN 513
Cdd:pfam14559   1 EGDYAEALELLEQALAEDPDNAEARLGLAEALLAL-GRLDEAEALLAALPAADPDDPRYAALLAK 64
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 428-504 8.81e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.99  E-value: 8.81e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063705226 428 LSQEPNNPLLLaNYAQFLYLVSNDHDRAEEYFKRAVGVEPKDAEAFSKYATfLWRARDDLWAAEETFLEAIDADPTN 504
Cdd:TIGR02917 458 EKKQPDNASLH-NLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLAR-IDIQEGNPDDAIQRFEKVLTIDPKN 532
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 428-476 1.53e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 40.69  E-value: 1.53e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1063705226 428 LSQEPNNPLLLANYAQfLYLVSNDHDRAEEYFKRAVGVEPkdAEAFSKY 476
Cdd:cd24142    27 LELEPNNVEALELLGE-ILLELGDVEEAREVLLRAIELDP--DGGYEKY 72
 
Name Accession Description Interval E-value
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 424-519 2.92e-12

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 63.87  E-value: 2.92e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705226 424 YQTELSQEPNNPLLLANYAQfLYLVSNDHDRAEEYFKRAVGVEPKDAEAFSKYATFLWRARDDLwAAEETFLEAIDADPT 503
Cdd:COG4235     6 LRQALAANPNDAEGWLLLGR-AYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTE-EAEELLERALALDPD 83

                          90
                  ....*....|....*.
gi 1063705226 504 NSYYAANYANFLWNTG 519
Cdd:COG4235    84 NPEALYLLGLAAFQQG 99
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 423-519 2.25e-11

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 61.75  E-value: 2.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705226 423 MYQTELSQEPNNPLLLANYAQfLYLVSNDHDRAEEYFKRAVGVEPKDAEAFSKYATFLWRARD-DlwAAEETFLEAIDAD 501
Cdd:COG4783    26 LLEKALELDPDNPEAFALLGE-ILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDyD--EALALLEKALKLD 102

                          90
                  ....*....|....*...
gi 1063705226 502 PTNSYYAANYANFLWNTG 519
Cdd:COG4783   103 PEHPEAYLRLARAYRALG 120
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 421-519 5.33e-10

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 58.05  E-value: 5.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705226 421 ELMYQTELSQEPNNPLLLANYAQFLYLVSNDHDRAEEYFKRAVGVEPKDAEAFSKYAtFLWRARDDLWAAEETFLEAIDA 500
Cdd:COG5010    39 EDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLA-LLYSRSGDKDEAKEYYEKALAL 117

                          90
                  ....*....|....*....
gi 1063705226 501 DPTNSYYAANYANFLWNTG 519
Cdd:COG5010   118 SPDNPNAYSNLAALLLSLG 136
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
424-519 8.65e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 59.25  E-value: 8.65e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705226 424 YQTELSQEPNNPLLLANYAQfLYLVSNDHDRAEEYFKRAVGVEPKDAEAFSKYAtFLWRARDDLWAAEETFLEAIDADPT 503
Cdd:COG0457    31 YEKALELDPDDAEALYNLGL-AYLRLGRYEEALADYEQALELDPDDAEALNNLG-LALQALGRYEEALEDYDKALELDPD 108

                          90
                  ....*....|....*.
gi 1063705226 504 NSYYAANYANFLWNTG 519
Cdd:COG0457   109 DAEALYNLGLALLELG 124
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
445-519 1.24e-09

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 55.18  E-value: 1.24e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063705226 445 LYLVSNDHDRAEEYFKRAVGVEPKDAEAFSKYATFLWRaRDDLWAAEEtFLEAIDADPTNSYYAANYANFLWNTG 519
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLE-QGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELG 73
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 423-513 2.32e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 58.59  E-value: 2.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705226 423 MYQTELSQEPNNPLLLANYAQfLYLVSNDHDRAEEYFKRAVGVEPKDAEAFSKYATfLWRARDDLWAAEETFLEAIDADP 502
Cdd:COG2956    64 IHQKLLERDPDRAEALLELAQ-DYLKAGLLDRAEELLEKLLELDPDDAEALRLLAE-IYEQEGDWEKAIEVLERLLKLGP 141

                          90
                  ....*....|.
gi 1063705226 503 TNSYYAANYAN 513
Cdd:COG2956   142 ENAHAYCELAE 152
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
424-519 4.42e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 57.32  E-value: 4.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705226 424 YQTELSQEPNNPLLLANYAqFLYLVSNDHDRAEEYFKRAVGVEPKDAEAFSKYATfLWRARDDLWAAEETFLEAIDADPT 503
Cdd:COG0457    65 YEQALELDPDDAEALNNLG-LALQALGRYEEALEDYDKALELDPDDAEALYNLGL-ALLELGRYDEAIEAYERALELDPD 142

                          90
                  ....*....|....*.
gi 1063705226 504 NSYYAANYANFLWNTG 519
Cdd:COG0457   143 DADALYNLGIALEKLG 158
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 423-504 4.69e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.81  E-value: 4.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705226 423 MYQTELSQEPNNPLLLANYAQfLYLVSNDHDRAEEYFKRAVGVEPKDAEAFSKYATFLWRArDDLWAAEETFLEAIDADP 502
Cdd:COG4783    60 LLHEALELDPDEPEARLNLGL-ALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRAL-GRPDEAIAALEKALELDP 137


                  ..
gi 1063705226 503 TN 504
Cdd:COG4783   138 DD 139
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 424-515 5.26e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 58.85  E-value: 5.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705226 424 YQTELSQEPNNPLLLANYAQfLYLVSNDHDRAEEYFKRAVGVEPKDAEAFSKYATFLWRARdDLWAAEETFLEAIDADPT 503
Cdd:COG3914   101 YRRALALNPDNAEALFNLGN-LLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLG-RLEEAIAALRRALELDPD 178

                          90
                  ....*....|..
gi 1063705226 504 NSYYAANYANFL 515
Cdd:COG3914   179 NAEALNNLGNAL 190
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 424-509 5.98e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 54.24  E-value: 5.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705226 424 YQTELSQEPNNPLLLANYAQFLYLvSNDHDRAEEYFKRAVGVEPKDAEAFSKYATFLWRARDDLwAAEETFLEAIDADPT 503
Cdd:COG4235    40 YEKALRLDPDNADALLDLAEALLA-AGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYA-EAIAAWQKLLALLPA 117


                  ....*.
gi 1063705226 504 NSYYAA 509
Cdd:COG4235   118 DAPARL 123
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 424-502 9.85e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 54.58  E-value: 9.85e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063705226 424 YQTELSQEPNNPLLLANYAqFLYLVSNDHDRAEEYFKRAVGVEPKDAEAFSKYATFLWRARDDLwAAEETFLEAIDADP 502
Cdd:COG5010    77 LEQALQLDPNNPELYYNLA-LLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDD-EAKAALQRALGTSP 153
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 445-519 1.23e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 53.66  E-value: 1.23e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063705226 445 LYLVSNDHDRAEEYFKRAVGVEPKDAEAFSKYAtFLWRARDDLWAAEETFLEAIDADPTNSYYAANYANFLWNTG 519
Cdd:COG4783    13 ALLLAGDYDEAEALLEKALELDPDNPEAFALLG-EILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAG 86
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 378-519 3.34e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 54.74  E-value: 3.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705226 378 VEEAERMqYSNIDDSLDQetrkrfvsHVEARVEAEEDtgYFKTEL------MYQTELSQEPNNPLLLANYAQfLYLVSND 451
Cdd:COG2956    58 YDRAIRI-HQKLLERDPD--------RAEALLELAQD--YLKAGLldraeeLLEKLLELDPDDAEALRLLAE-IYEQEGD 125

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063705226 452 HDRAEEYFKRAVGVEPKDAEAFSKYATfLWRARDDLWAAEETFLEAIDADPTNSYYAANYANFLWNTG 519
Cdd:COG2956   126 WEKAIEVLERLLKLGPENAHAYCELAE-LYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQG 192
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
423-502 9.14e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 49.78  E-value: 9.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705226 423 MYQTELSQEPNNPLLLANYAQFLYLvSNDHDRAEEyFKRAVGVEPKDAEAFSKYATFLWRaRDDLWAAEETFLEAIDADP 502
Cdd:COG3063    14 YYEKALELDPDNADALNNLGLLLLE-QGRYDEAIA-LEKALKLDPNNAEALLNLAELLLE-LGDYDEALAYLERALELDP 90
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
428-519 9.40e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 53.09  E-value: 9.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705226 428 LSQEPNNPLLLANYAqFLYLVSNDHDRAEEYFKRAVGVEPKDAEAFSKYATFLWRArDDLWAAEETFLEAIDADPTNSYY 507
Cdd:COG0457     1 LELDPDDAEAYNNLG-LAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRL-GRYEEALADYEQALELDPDDAEA 78

                          90
                  ....*....|..
gi 1063705226 508 AANYANFLWNTG 519
Cdd:COG0457    79 LNNLGLALQALG 90
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 423-519 1.23e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 50.11  E-value: 1.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705226 423 MYQTELSQEPNNPLLLANYAQfLYLVSNDHDRAEEYFKRAVGVEPKDAEAFSKYATfLWRARDDLWAAEETFLEAIDADP 502
Cdd:COG2956   132 VLERLLKLGPENAHAYCELAE-LYLEQGDYDEAIEALEKALKLDPDCARALLLLAE-LYLEQGDYEEAIAALERALEQDP 209

                          90
                  ....*....|....*..
gi 1063705226 503 TNSYYAANYANFLWNTG 519
Cdd:COG2956   210 DYLPALPRLAELYEKLG 226
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 436-519 4.10e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.57  E-value: 4.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705226 436 LLLANYAQF-------LYLVSNDHDRAEEYFKRAVGVEPKDAEAFSKYATfLWRARDDLWAAEETFLEAIDADPTNSYYA 508
Cdd:COG2956     1 LLLPVAAALgwyfkglNYLLNGQPDKAIDLLEEALELDPETVEAHLALGN-LYRRRGEYDRAIRIHQKLLERDPDRAEAL 79

                          90
                  ....*....|.
gi 1063705226 509 ANYANFLWNTG 519
Cdd:COG2956    80 LELAQDYLKAG 90
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
423-515 3.28e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.38  E-value: 3.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705226 423 MYQTELSQEPNNPLLLANYAQfLYLVSNDHDRAEEYFKRAVGVEPKDAEAFSKYATFLWRARDDLwAAEETFLEAIDADP 502
Cdd:COG0457    98 DYDKALELDPDDAEALYNLGL-ALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYE-EALELLEKLEAAAL 175

                          90
                  ....*....|...
gi 1063705226 503 TNSYYAANYANFL 515
Cdd:COG0457   176 AALLAAALGEAAL 188
TPR_19 pfam14559
Tetratricopeptide repeat;
449-513 9.16e-05

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 40.65  E-value: 9.16e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063705226 449 SNDHDRAEEYFKRAVGVEPKDAEAFSKYATFLWRArDDLWAAEETFLEAIDADPTNSYYAANYAN 513
Cdd:pfam14559   1 EGDYAEALELLEQALAEDPDNAEARLGLAEALLAL-GRLDEAEALLAALPAADPDDPRYAALLAK 64
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 428-509 1.38e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.95  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705226 428 LSQEPNNPLLLANYAQfLYLVSNDHDRAEEYFKRAVGVEPKDAEAFSKYATFLwRARDDLWAAEETFLEAIDADPTNSYY 507
Cdd:COG2956   171 LKLDPDCARALLLLAE-LYLEQGDYEEAIAALERALEQDPDYLPALPRLAELY-EKLGDPEEALELLRKALELDPSDDLL 248


                  ..
gi 1063705226 508 AA 509
Cdd:COG2956   249 LA 250
TPR_19 pfam14559
Tetratricopeptide repeat;
423-477 5.12e-04

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 38.33  E-value: 5.12e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1063705226 423 MYQTELSQEPNNPLLLANYAQfLYLVSNDHDRAEEYFKRAVGVEPKDAEAFSKYA 477
Cdd:pfam14559  10 LLEQALAEDPDNAEARLGLAE-ALLALGRLDEAEALLAALPAADPDDPRYAALLA 63
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 428-504 8.81e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.99  E-value: 8.81e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063705226 428 LSQEPNNPLLLaNYAQFLYLVSNDHDRAEEYFKRAVGVEPKDAEAFSKYATfLWRARDDLWAAEETFLEAIDADPTN 504
Cdd:TIGR02917 458 EKKQPDNASLH-NLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLAR-IDIQEGNPDDAIQRFEKVLTIDPKN 532
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 445-505 1.07e-03

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 37.70  E-value: 1.07e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063705226 445 LYLVSNDHDRAEEYFKRAV---GVEPKDAEAFSKYATFLWRARdDLWAAEETFLEAIDADPTNS 505
Cdd:pfam13432   6 AALRAGDYDDAAAALEAALarfPESPDAAAALLLLGLAALRQG-RLAEAAAAYRAALRAAPGDP 68
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 428-476 1.53e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 40.69  E-value: 1.53e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1063705226 428 LSQEPNNPLLLANYAQfLYLVSNDHDRAEEYFKRAVGVEPkdAEAFSKY 476
Cdd:cd24142    27 LELEPNNVEALELLGE-ILLELGDVEEAREVLLRAIELDP--DGGYEKY 72
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 406-519 3.10e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 40.36  E-value: 3.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705226 406 EARVEAEEDTGYFKTELMYQTELSQEPNNPLLLANYAQFLYLvSNDHDRAEEYFKRAVGVEPKDAEAFSKYATFLwRARD 485
Cdd:COG3914    49 AALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQA-LGRYEEALALYRRALALNPDNAEALFNLGNLL-LALG 126

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1063705226 486 DLWAAEETFLEAIDADPTNSYYAANYANFLWNTG 519
Cdd:COG3914   127 RLEEALAALRRALALNPDFAEAYLNLGEALRRLG 160
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 424-522 3.11e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.45  E-value: 3.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705226 424 YQTELSQEPNNPLLLANYAqFLYLvSNDHDRAEEYFKRAVGVEPKDAEAFSKYATFLWRaRDDLWAAEETFLEAIDADPT 503
Cdd:TIGR02917 793 YQTVVKKAPDNAVVLNNLA-WLYL-ELKDPRALEYAERALKLAPNIPAILDTLGWLLVE-KGEADRALPLLRKAVNIAPE 869

                          90
                  ....*....|....*....
gi 1063705226 504 NSYYAANYANFLWNTGGDD 522
Cdd:TIGR02917 870 AAAIRYHLALALLATGRKA 888
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
424-506 3.25e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 39.13  E-value: 3.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705226 424 YQTELSQEPNNPLLLANYAQ--FLYLVSNDHDRAEEYFKRAVGVEPKDAEAFSKYAtFLWRARDDLWAAEETFLEAIDAD 501
Cdd:COG4785    59 AAERIDRALALPDLAQLYYErgVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRG-LAYLLLGDYDAALEDFDRALELD 137


                  ....*
gi 1063705226 502 PTNSY 506
Cdd:COG4785   138 PDYAY 142
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 419-505 3.53e-03

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 39.24  E-value: 3.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705226 419 KTELMYQTELSQEPNNPLLLANYAQFLYlVSNDHDRAEEYFKRAVGVE--PKDAEAFSKYATFLWRARDDLwAAEETFLE 496
Cdd:TIGR02521  83 KAEDSFRRALTLNPNNGDVLNNYGTFLC-QQGKYEQAMQQFEQAIEDPlyPQPARSLENAGLCALKAGDFD-KAEKYLTR 160


                  ....*....
gi 1063705226 497 AIDADPTNS 505
Cdd:TIGR02521 161 ALQIDPQRP 169
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
424-506 4.58e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 38.74  E-value: 4.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705226 424 YQTELSQEPNNPLLLANYAqFLYLVSNDHDRAEEYFKRAVGVEPKDAEAfskyatFLWRA-----RDDLWAAEETFLEAI 498
Cdd:COG4785    96 FDQALELDPDLAEAYNNRG-LAYLLLGDYDAALEDFDRALELDPDYAYA------YLNRGialyyLGRYELAIADLEKAL 168


                  ....*...
gi 1063705226 499 DADPTNSY 506
Cdd:COG4785   169 ELDPNDPE 176
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 454-522 9.42e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.52  E-value: 9.42e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063705226 454 RAEEYFKRAVGVEPKDAEAFSKYAtFLWRARDDLWAAEETFLEAIDADPTNSYYAANYANFLWNTGGDD 522
Cdd:COG4235     1 EAIARLRQALAANPNDAEGWLLLG-RAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTE 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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