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Conserved domains on  [gi|1063717085|ref|NP_001326518|]
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Sodium Bile acid symporter family [Arabidopsis thaliana]

Protein Classification

bile acid:sodium symporter family protein( domain architecture ID 139610)

bile acid:sodium symporter (BASS) family protein, similar to Homo sapiens solute carrier family 10 (SLC10) proteins, which comprises influx transporters of bile acids, steroidal hormones, various drugs, and several other substrates

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SBF super family cl19217
Sodium Bile acid symporter family; This family consists of Na+/bile acid co-transporters. ...
81-327 1.11e-25

Sodium Bile acid symporter family; This family consists of Na+/bile acid co-transporters. These transmembrane proteins function in the liver in the uptake of bile acids from portal blood plasma a process mediated by the co-transport of Na+. Also in the family is ARC3 from S. cerevisiae; this is a putative transmembrane protein involved in resistance to arsenic compounds.


The actual alignment was detected with superfamily member pfam13593:

Pssm-ID: 450274  Cd Length: 313  Bit Score: 104.97  E-value: 1.11e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063717085  81 NFLPLALVSGVGLGFANPTLGC----LADKYSfTKISTCGIFIISGLTLRTEAIGAAVKGWPLGLFGLISILLLTPS--- 153
Cdd:pfam13593   1 QWFLLGLVLAILLASLLPVFGAaggpIRAEYV-ITYGVALIFFLSGLRLSTEELLAGLRNWRLHLFVQLFTFVLFPLlgl 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063717085 154 -FSRLIMLvqLQPRELVTGLGIFCCMPTTLSSGVALTHLAGGNAALALAVTVASNLLGILTIPFWVSRYIAGGvGVSFPT 232
Cdd:pfam13593  80 gLSSLLPA--ALPPELLIGFLLLAALPTTVSSSVAMTSQAGGNVAAAVCNASIGNLLGVFLTPALVGLLLGGG-GAGIDY 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063717085 233 DQLFRSLIVTLLIPLIIGKVIResfKGFANFVDNNRKLFSKINAICLSLVPWIQVSRS--RSLLLSVQPKVFLAAVGIGI 310
Cdd:pfam13593 157 GAVLKKLGLQVLLPLVLGQLLR---PWFPKWTKRHKKLLKKVDSGVILLIVYTSFSTAfvQGAFHSVSHSILLVIFNVGL 233
                         250
                  ....*....|....*..
gi 1063717085 311 LLHLSLLAFNAVSIRIL 327
Cdd:pfam13593 234 YLLAVVLGATWFLARLL 250
 
Name Accession Description Interval E-value
SBF_like pfam13593
SBF-like CPA transporter family (DUF4137); These family members are 7TM putative membrane ...
81-327 1.11e-25

SBF-like CPA transporter family (DUF4137); These family members are 7TM putative membrane transporter proteins. The family is similar to the SBF family of bile-acid symporters, pfam01758.


Pssm-ID: 433336  Cd Length: 313  Bit Score: 104.97  E-value: 1.11e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063717085  81 NFLPLALVSGVGLGFANPTLGC----LADKYSfTKISTCGIFIISGLTLRTEAIGAAVKGWPLGLFGLISILLLTPS--- 153
Cdd:pfam13593   1 QWFLLGLVLAILLASLLPVFGAaggpIRAEYV-ITYGVALIFFLSGLRLSTEELLAGLRNWRLHLFVQLFTFVLFPLlgl 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063717085 154 -FSRLIMLvqLQPRELVTGLGIFCCMPTTLSSGVALTHLAGGNAALALAVTVASNLLGILTIPFWVSRYIAGGvGVSFPT 232
Cdd:pfam13593  80 gLSSLLPA--ALPPELLIGFLLLAALPTTVSSSVAMTSQAGGNVAAAVCNASIGNLLGVFLTPALVGLLLGGG-GAGIDY 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063717085 233 DQLFRSLIVTLLIPLIIGKVIResfKGFANFVDNNRKLFSKINAICLSLVPWIQVSRS--RSLLLSVQPKVFLAAVGIGI 310
Cdd:pfam13593 157 GAVLKKLGLQVLLPLVLGQLLR---PWFPKWTKRHKKLLKKVDSGVILLIVYTSFSTAfvQGAFHSVSHSILLVIFNVGL 233
                         250
                  ....*....|....*..
gi 1063717085 311 LLHLSLLAFNAVSIRIL 327
Cdd:pfam13593 234 YLLAVVLGATWFLARLL 250
YfeH COG0385
Predicted Na+-dependent transporter YfeH [General function prediction only];
81-327 1.63e-16

Predicted Na+-dependent transporter YfeH [General function prediction only];


Pssm-ID: 440154  Cd Length: 294  Bit Score: 78.66  E-value: 1.63e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063717085  81 NFLPLALVSGVGLGFANPTlgcladkySFTKISTCGIFII---SGLTLRTEAIGAAVKGWPLGLFGLISILLLTPSFSRL 157
Cdd:COG0385     1 DWFLLLLLLAVVLALLLPA--------AFEPLLPLLLALImfgMGLTLSPEDFKRVLRRPRLVLLGLLAQFVLMPLLALA 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063717085 158 IMLVQLQPRELVTGLGIFCCMPTTLSSGVaLTHLAGGNAALALAVTVASNLLGILTIPFWVSrYIAGGVGVSFPTDQLFR 237
Cdd:COG0385    73 LALLFGLPPELALGLLLLAACPGGVASNV-FTSLARGNVALSVSLTAVSTLLAPFLTPLLVA-LLLGLQGVEVDPLDMIL 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063717085 238 SLIVTLLIPLIIGKVIRESFKGFAnfvDNNRKLFSKINAICLSLVPWIQVSRSRSLLLSVQPKVFLAAvgigILLHLSLL 317
Cdd:COG0385   151 SLLLIVLLPLVLGMLLRRLLPKWA---ERLKKPLPLVSRLAILLIVYAAFAANVDNLLSVGLLVLLAV----LLLNALGL 223
                         250
                  ....*....|
gi 1063717085 318 AFNAVSIRIL 327
Cdd:COG0385   224 LLGYLLARLL 233
 
Name Accession Description Interval E-value
SBF_like pfam13593
SBF-like CPA transporter family (DUF4137); These family members are 7TM putative membrane ...
81-327 1.11e-25

SBF-like CPA transporter family (DUF4137); These family members are 7TM putative membrane transporter proteins. The family is similar to the SBF family of bile-acid symporters, pfam01758.


Pssm-ID: 433336  Cd Length: 313  Bit Score: 104.97  E-value: 1.11e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063717085  81 NFLPLALVSGVGLGFANPTLGC----LADKYSfTKISTCGIFIISGLTLRTEAIGAAVKGWPLGLFGLISILLLTPS--- 153
Cdd:pfam13593   1 QWFLLGLVLAILLASLLPVFGAaggpIRAEYV-ITYGVALIFFLSGLRLSTEELLAGLRNWRLHLFVQLFTFVLFPLlgl 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063717085 154 -FSRLIMLvqLQPRELVTGLGIFCCMPTTLSSGVALTHLAGGNAALALAVTVASNLLGILTIPFWVSRYIAGGvGVSFPT 232
Cdd:pfam13593  80 gLSSLLPA--ALPPELLIGFLLLAALPTTVSSSVAMTSQAGGNVAAAVCNASIGNLLGVFLTPALVGLLLGGG-GAGIDY 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063717085 233 DQLFRSLIVTLLIPLIIGKVIResfKGFANFVDNNRKLFSKINAICLSLVPWIQVSRS--RSLLLSVQPKVFLAAVGIGI 310
Cdd:pfam13593 157 GAVLKKLGLQVLLPLVLGQLLR---PWFPKWTKRHKKLLKKVDSGVILLIVYTSFSTAfvQGAFHSVSHSILLVIFNVGL 233
                         250
                  ....*....|....*..
gi 1063717085 311 LLHLSLLAFNAVSIRIL 327
Cdd:pfam13593 234 YLLAVVLGATWFLARLL 250
YfeH COG0385
Predicted Na+-dependent transporter YfeH [General function prediction only];
81-327 1.63e-16

Predicted Na+-dependent transporter YfeH [General function prediction only];


Pssm-ID: 440154  Cd Length: 294  Bit Score: 78.66  E-value: 1.63e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063717085  81 NFLPLALVSGVGLGFANPTlgcladkySFTKISTCGIFII---SGLTLRTEAIGAAVKGWPLGLFGLISILLLTPSFSRL 157
Cdd:COG0385     1 DWFLLLLLLAVVLALLLPA--------AFEPLLPLLLALImfgMGLTLSPEDFKRVLRRPRLVLLGLLAQFVLMPLLALA 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063717085 158 IMLVQLQPRELVTGLGIFCCMPTTLSSGVaLTHLAGGNAALALAVTVASNLLGILTIPFWVSrYIAGGVGVSFPTDQLFR 237
Cdd:COG0385    73 LALLFGLPPELALGLLLLAACPGGVASNV-FTSLARGNVALSVSLTAVSTLLAPFLTPLLVA-LLLGLQGVEVDPLDMIL 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063717085 238 SLIVTLLIPLIIGKVIRESFKGFAnfvDNNRKLFSKINAICLSLVPWIQVSRSRSLLLSVQPKVFLAAvgigILLHLSLL 317
Cdd:COG0385   151 SLLLIVLLPLVLGMLLRRLLPKWA---ERLKKPLPLVSRLAILLIVYAAFAANVDNLLSVGLLVLLAV----LLLNALGL 223
                         250
                  ....*....|
gi 1063717085 318 AFNAVSIRIL 327
Cdd:COG0385   224 LLGYLLARLL 233
SBF pfam01758
Sodium Bile acid symporter family; This family consists of Na+/bile acid co-transporters. ...
122-283 2.21e-03

Sodium Bile acid symporter family; This family consists of Na+/bile acid co-transporters. These transmembrane proteins function in the liver in the uptake of bile acids from portal blood plasma a process mediated by the co-transport of Na+. Also in the family is ARC3 from S. cerevisiae; this is a putative transmembrane protein involved in resistance to arsenic compounds.


Pssm-ID: 366796  Cd Length: 191  Bit Score: 38.81  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063717085 122 GLTLRTEAIGAAVK-GWPLGLfGLISILLLTP----SFSRLIMLVQLQPRELVTGLGIFCCMPTTLSSGVAlTHLAGGNA 196
Cdd:pfam01758  12 GLKVRYEDFKELFRrPKALLL-GLLLQWVIMPllmfLLAKFFLRDFPLPPELAVGLILVGCAPGGAMSNVW-TYLAKGDV 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063717085 197 ALALAVTVASNLLGILTIPFWV---SRYIAGGVGVSFPTDQLFRSLIVTLLIPLIIGKVIRE-SFKGFANFVDNNRKLFS 272
Cdd:pfam01758  90 ELSVVMVALSTLLAILFTPLLLyllAGLLVEGTTLPVPIEEIAKSVLIYVIIPLIAGILTRYfLPKHFESRILPAVPPIS 169
                         170
                  ....*....|.
gi 1063717085 273 KINAICLSLVP 283
Cdd:pfam01758 170 LIGLLLTIVVI 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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