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Conserved domains on  [gi|1063710352|ref|NP_001327466|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
400-719 7.07e-35

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.12  E-value: 7.07e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  400 SEGVSFTTCSEDGTIRLWDLAFQVNPLEANASSNPSES---STQGIMhLASAG---------IFERDLVET-CGSKFGFR 466
Cdd:COG2319     88 PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSvafSPDGKT-LASGSadgtvrlwdLATGKLLRTlTGHSGAVT 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  467 ALAVSEDGKYLAAGDCGGNLHIYDLQESEYTCFMDAHEAEIQSLSFSfPvltnvDSEnassLLASGGKGRAIHIYDVKRN 546
Cdd:COG2319    167 SVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS-P-----DGK----LLASGSADGTVRLWDLATG 236

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  547 fDPVGSVCG-SAAVTSVKFACNGRKMLTSGADR-LQMFDVNrkassvrlSPSHTQTLSH--GTIYDVAVDPTSGLVVTVG 622
Cdd:COG2319    237 -KLLRTLTGhSGSVRSVAFSPDGRLLASGSADGtVRLWDLA--------TGELLRTLTGhsGGVNSVAFSPDGKLLASGS 307

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  623 QDKKINIFDIESGKLVRSFKqdrDHGDPVK-VILDPSCNYLVCSYSNRTICFVDFVTGELVAQATGHGEAVTGVIFLPDC 701
Cdd:COG2319    308 DDGTVRLWDLATGKLLRTLT---GHTGAVRsVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDG 384

                          330
                   ....*....|....*...
gi 1063710352  702 KHIISVASDGCIFVWKLP 719
Cdd:COG2319    385 RTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
75-544 4.35e-23

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 4.35e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352   75 VAISQNGRFVAAGESPNlsAVLIWDCDTLGLVSELKGHLYGSQCLSFSPNGEYLVSVG--GYIYLWDWRKSILVAKVKAS 152
Cdd:COG2319     84 VAFSPDGRLLASASADG--TVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSadGTVRLWDLATGKLLRTLTGH 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  153 SNcsEITSVTFSSNGKFIVT-SGNKHLKFWTVGSFQRTRsskvgSLAFHGNqtddgfqkgnsfvsvisanrvnssgsdeq 231
Cdd:COG2319    162 SG--AVTSVAFSPDGKLLASgSDDGTVRLWDLATGKLLR-----TLTGHTG----------------------------- 205

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  232 ideviSIYALteagvlmlmsygmlikksvdlkvqkcfALSASSRLIACACSKGMVQLFTPETLDYAGTIQFSDAkssnte 311
Cdd:COG2319    206 -----AVRSV---------------------------AFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSG------ 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  312 nlsqspepkniesspgiFPDAVAcqFSTTDKLVVIYG-NRSLYVWDVDDvNKPTRcsMMISHSAGIWDIKnlscgnmHSP 390
Cdd:COG2319    248 -----------------SVRSVA--FSPDGRLLASGSaDGTVRLWDLAT-GELLR--TLTGHSGGVNSVA-------FSP 298

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  391 TAACVArgcsegvsftTCSEDGTIRLWDLAfqvnpleanassnpsesstqgimhlasagifERDLVETC-GSKFGFRALA 469
Cdd:COG2319    299 DGKLLA----------SGSDDGTVRLWDLA-------------------------------TGKLLRTLtGHTGAVRSVA 337

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063710352  470 VSEDGKYLAAGDCGGNLHIYDLQESEYTCFMDAHEAEIQSLSFSfpvltnvdseNASSLLASGGKGRAIHIYDVK 544
Cdd:COG2319    338 FSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS----------PDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
400-719 7.07e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.12  E-value: 7.07e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  400 SEGVSFTTCSEDGTIRLWDLAFQVNPLEANASSNPSES---STQGIMhLASAG---------IFERDLVET-CGSKFGFR 466
Cdd:COG2319     88 PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSvafSPDGKT-LASGSadgtvrlwdLATGKLLRTlTGHSGAVT 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  467 ALAVSEDGKYLAAGDCGGNLHIYDLQESEYTCFMDAHEAEIQSLSFSfPvltnvDSEnassLLASGGKGRAIHIYDVKRN 546
Cdd:COG2319    167 SVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS-P-----DGK----LLASGSADGTVRLWDLATG 236

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  547 fDPVGSVCG-SAAVTSVKFACNGRKMLTSGADR-LQMFDVNrkassvrlSPSHTQTLSH--GTIYDVAVDPTSGLVVTVG 622
Cdd:COG2319    237 -KLLRTLTGhSGSVRSVAFSPDGRLLASGSADGtVRLWDLA--------TGELLRTLTGhsGGVNSVAFSPDGKLLASGS 307

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  623 QDKKINIFDIESGKLVRSFKqdrDHGDPVK-VILDPSCNYLVCSYSNRTICFVDFVTGELVAQATGHGEAVTGVIFLPDC 701
Cdd:COG2319    308 DDGTVRLWDLATGKLLRTLT---GHTGAVRsVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDG 384

                          330
                   ....*....|....*...
gi 1063710352  702 KHIISVASDGCIFVWKLP 719
Cdd:COG2319    385 RTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 466-718 1.30e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.89  E-value: 1.30e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  466 RALAVSEDGKYLAAGDCGGNLHIYDLQESEYTCFMDAHEAEIQSLSFSfpvltnvdseNASSLLASGGKGRAIHIYDVKr 545
Cdd:cd00200     13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAS----------ADGTYLASGSSDKTIRLWDLE- 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  546 NFDPVGSVCG-SAAVTSVKFACNGRKMLTSGADR-LQMFDVnRKASSVRLSPSHTqtlshGTIYDVAVDPTSGLVVTVGQ 623
Cdd:cd00200     82 TGECVRTLTGhTSYVSSVAFSPDGRILSSSSRDKtIKVWDV-ETGKCLTTLRGHT-----DWVNSVAFSPDGTFVASSSQ 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  624 DKKINIFDIESGKLVRSFKqdrDHGDPVK-VILDPSCNYLVCSYSNRTICFVDFVTGELVAQATGHGEAVTGVIFLPDCK 702
Cdd:cd00200    156 DGTIKLWDLRTGKCVATLT---GHTGEVNsVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGY 232

                          250
                   ....*....|....*.
gi 1063710352  703 HIISVASDGCIFVWKL 718
Cdd:cd00200    233 LLASGSEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
75-544 4.35e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 4.35e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352   75 VAISQNGRFVAAGESPNlsAVLIWDCDTLGLVSELKGHLYGSQCLSFSPNGEYLVSVG--GYIYLWDWRKSILVAKVKAS 152
Cdd:COG2319     84 VAFSPDGRLLASASADG--TVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSadGTVRLWDLATGKLLRTLTGH 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  153 SNcsEITSVTFSSNGKFIVT-SGNKHLKFWTVGSFQRTRsskvgSLAFHGNqtddgfqkgnsfvsvisanrvnssgsdeq 231
Cdd:COG2319    162 SG--AVTSVAFSPDGKLLASgSDDGTVRLWDLATGKLLR-----TLTGHTG----------------------------- 205

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  232 ideviSIYALteagvlmlmsygmlikksvdlkvqkcfALSASSRLIACACSKGMVQLFTPETLDYAGTIQFSDAkssnte 311
Cdd:COG2319    206 -----AVRSV---------------------------AFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSG------ 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  312 nlsqspepkniesspgiFPDAVAcqFSTTDKLVVIYG-NRSLYVWDVDDvNKPTRcsMMISHSAGIWDIKnlscgnmHSP 390
Cdd:COG2319    248 -----------------SVRSVA--FSPDGRLLASGSaDGTVRLWDLAT-GELLR--TLTGHSGGVNSVA-------FSP 298

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  391 TAACVArgcsegvsftTCSEDGTIRLWDLAfqvnpleanassnpsesstqgimhlasagifERDLVETC-GSKFGFRALA 469
Cdd:COG2319    299 DGKLLA----------SGSDDGTVRLWDLA-------------------------------TGKLLRTLtGHTGAVRSVA 337

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063710352  470 VSEDGKYLAAGDCGGNLHIYDLQESEYTCFMDAHEAEIQSLSFSfpvltnvdseNASSLLASGGKGRAIHIYDVK 544
Cdd:COG2319    338 FSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS----------PDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 69-418 1.05e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.55  E-value: 1.05e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352   69 PKPLSCVAISQNGRFVAAGeSPNlSAVLIWDCDTLGLVSELKGHLYGSQCLSFSPNGEYLVSVG--GYIYLWDWRKSILV 146
Cdd:cd00200      9 TGGVTCVAFSPDGKLLATG-SGD-GTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSsdKTIRLWDLETGECV 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  147 AKVKASsnCSEITSVTFSSNGKFIVTSG-NKHLKFWTVGSFQrtrssKVGSLAFHgnqTDDGfqkgnSFVSVISANRVNS 225
Cdd:cd00200     87 RTLTGH--TSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGK-----CLTTLRGH---TDWV-----NSVAFSPDGTFVA 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  226 SGSDeqiDEVISIYALTEAGVLMLMsYGMliKKSVdlkvqKCFALSASSRLIACACSKGMVQLFTPETLDYAGTIQFSDA 305
Cdd:cd00200    152 SSSQ---DGTIKLWDLRTGKCVATL-TGH--TGEV-----NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN 220

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  306 KssntenlsqspepkniesspgifpdAVACQFSTTDKLVVIYG-NRSLYVWDVDDvnkpTRCSMMIS-HSAGIWDIknls 383
Cdd:cd00200    221 G-------------------------VNSVAFSPDGYLLASGSeDGTIRVWDLRT----GECVQTLSgHTNSVTSL---- 267

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 1063710352  384 cgnMHSPTAACVArgcsegvsftTCSEDGTIRLWD 418
Cdd:cd00200    268 ---AWSPDGKRLA----------SGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 678-717 1.89e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.89e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1063710352   678 TGELVAQATGHGEAVTGVIFLPDCKHIISVASDGCIFVWK 717
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
679-716 1.43e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.43e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1063710352  679 GELVAQATGHGEAVTGVIFLPDCKHIISVASDGCIFVW 716
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 102-139 1.83e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.83e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1063710352   102 TLGLVSELKGHLYGSQCLSFSPNGEYLVSVG--GYIYLWD 139
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSddGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
400-719 7.07e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.12  E-value: 7.07e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  400 SEGVSFTTCSEDGTIRLWDLAFQVNPLEANASSNPSES---STQGIMhLASAG---------IFERDLVET-CGSKFGFR 466
Cdd:COG2319     88 PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSvafSPDGKT-LASGSadgtvrlwdLATGKLLRTlTGHSGAVT 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  467 ALAVSEDGKYLAAGDCGGNLHIYDLQESEYTCFMDAHEAEIQSLSFSfPvltnvDSEnassLLASGGKGRAIHIYDVKRN 546
Cdd:COG2319    167 SVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS-P-----DGK----LLASGSADGTVRLWDLATG 236

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  547 fDPVGSVCG-SAAVTSVKFACNGRKMLTSGADR-LQMFDVNrkassvrlSPSHTQTLSH--GTIYDVAVDPTSGLVVTVG 622
Cdd:COG2319    237 -KLLRTLTGhSGSVRSVAFSPDGRLLASGSADGtVRLWDLA--------TGELLRTLTGhsGGVNSVAFSPDGKLLASGS 307

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  623 QDKKINIFDIESGKLVRSFKqdrDHGDPVK-VILDPSCNYLVCSYSNRTICFVDFVTGELVAQATGHGEAVTGVIFLPDC 701
Cdd:COG2319    308 DDGTVRLWDLATGKLLRTLT---GHTGAVRsVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDG 384

                          330
                   ....*....|....*...
gi 1063710352  702 KHIISVASDGCIFVWKLP 719
Cdd:COG2319    385 RTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
466-718 2.81e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.78  E-value: 2.81e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  466 RALAVSEDGKYLAAGDCGGNLHIYDLQESEYTCFMDAHEAEIQSLSFSfPvltnvDsenaSSLLASGGKGRAIHIYDVKR 545
Cdd:COG2319     82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS-P-----D----GKTLASGSADGTVRLWDLAT 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  546 NfDPVGSVCG-SAAVTSVKFACNGRKMLTSGADR-LQMFDVNRKASSVRLsPSHTqtlshGTIYDVAVDPTSGLVVTVGQ 623
Cdd:COG2319    152 G-KLLRTLTGhSGAVTSVAFSPDGKLLASGSDDGtVRLWDLATGKLLRTL-TGHT-----GAVRSVAFSPDGKLLASGSA 224

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  624 DKKINIFDIESGKLVRSFKqdrDHGDPVK-VILDPSCNYLVCSYSNRTICFVDFVTGELVAQATGHGEAVTGVIFLPDCK 702
Cdd:COG2319    225 DGTVRLWDLATGKLLRTLT---GHSGSVRsVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGK 301

                          250
                   ....*....|....*.
gi 1063710352  703 HIISVASDGCIFVWKL 718
Cdd:COG2319    302 LLASGSDDGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 466-718 1.30e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.89  E-value: 1.30e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  466 RALAVSEDGKYLAAGDCGGNLHIYDLQESEYTCFMDAHEAEIQSLSFSfpvltnvdseNASSLLASGGKGRAIHIYDVKr 545
Cdd:cd00200     13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAS----------ADGTYLASGSSDKTIRLWDLE- 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  546 NFDPVGSVCG-SAAVTSVKFACNGRKMLTSGADR-LQMFDVnRKASSVRLSPSHTqtlshGTIYDVAVDPTSGLVVTVGQ 623
Cdd:cd00200     82 TGECVRTLTGhTSYVSSVAFSPDGRILSSSSRDKtIKVWDV-ETGKCLTTLRGHT-----DWVNSVAFSPDGTFVASSSQ 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  624 DKKINIFDIESGKLVRSFKqdrDHGDPVK-VILDPSCNYLVCSYSNRTICFVDFVTGELVAQATGHGEAVTGVIFLPDCK 702
Cdd:cd00200    156 DGTIKLWDLRTGKCVATLT---GHTGEVNsVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGY 232

                          250
                   ....*....|....*.
gi 1063710352  703 HIISVASDGCIFVWKL 718
Cdd:cd00200    233 LLASGSEDGTIRVWDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 503-718 1.45e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.89  E-value: 1.45e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  503 HEAEIQSLSFSfpvltnvdseNASSLLASGGKGRAIHIYDVKRNfDPVGSVCG-SAAVTSVKFACNGRKMLTSGADR-LQ 580
Cdd:cd00200      8 HTGGVTCVAFS----------PDGKLLATGSGDGTIKVWDLETG-ELLRTLKGhTGPVRDVAASADGTYLASGSSDKtIR 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  581 MFDVNRKASSVRLSpSHTQTlshgtIYDVAVDPTSGLVVTVGQDKKINIFDIESGKLVRSFkqdRDHGDPVK-VILDPSC 659
Cdd:cd00200     77 LWDLETGECVRTLT-GHTSY-----VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL---RGHTDWVNsVAFSPDG 147

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063710352  660 NYLVCSYSNRTICFVDFVTGELVAQATGHGEAVTGVIFLPDCKHIISVASDGCIFVWKL 718
Cdd:cd00200    148 TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 407-717 5.10e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 106.27  E-value: 5.10e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  407 TCSEDGTIRLWDLAFqvnpleanassnpsesstqgimhlasaGIFERDLvetCGSKFGFRALAVSEDGKYLAAGDCGGNL 486
Cdd:cd00200     26 TGSGDGTIKVWDLET---------------------------GELLRTL---KGHTGPVRDVAASADGTYLASGSSDKTI 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  487 HIYDLQESEYTCFMDAHEAEIQSLSFSfpvltnvdseNASSLLASGGKGRAIHIYDVkRNFDPVGSVCG-SAAVTSVKFA 565
Cdd:cd00200     76 RLWDLETGECVRTLTGHTSYVSSVAFS----------PDGRILSSSSRDKTIKVWDV-ETGKCLTTLRGhTDWVNSVAFS 144

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  566 CNGRKMLTSGADR-LQMFDVnRKASSVRLSPSHTqtlshGTIYDVAVDPTSGLVVTVGQDKKINIFDIESGKLVRSFkqd 644
Cdd:cd00200    145 PDGTFVASSSQDGtIKLWDL-RTGKCVATLTGHT-----GEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL--- 215

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063710352  645 RDHGDPV-KVILDPSCNYLVCSYSNRTICFVDFVTGELVAQATGHGEAVTGVIFLPDCKHIISVASDGCIFVWK 717
Cdd:cd00200    216 RGHENGVnSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
75-544 4.35e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 4.35e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352   75 VAISQNGRFVAAGESPNlsAVLIWDCDTLGLVSELKGHLYGSQCLSFSPNGEYLVSVG--GYIYLWDWRKSILVAKVKAS 152
Cdd:COG2319     84 VAFSPDGRLLASASADG--TVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSadGTVRLWDLATGKLLRTLTGH 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  153 SNcsEITSVTFSSNGKFIVT-SGNKHLKFWTVGSFQRTRsskvgSLAFHGNqtddgfqkgnsfvsvisanrvnssgsdeq 231
Cdd:COG2319    162 SG--AVTSVAFSPDGKLLASgSDDGTVRLWDLATGKLLR-----TLTGHTG----------------------------- 205

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  232 ideviSIYALteagvlmlmsygmlikksvdlkvqkcfALSASSRLIACACSKGMVQLFTPETLDYAGTIQFSDAkssnte 311
Cdd:COG2319    206 -----AVRSV---------------------------AFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSG------ 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  312 nlsqspepkniesspgiFPDAVAcqFSTTDKLVVIYG-NRSLYVWDVDDvNKPTRcsMMISHSAGIWDIKnlscgnmHSP 390
Cdd:COG2319    248 -----------------SVRSVA--FSPDGRLLASGSaDGTVRLWDLAT-GELLR--TLTGHSGGVNSVA-------FSP 298

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  391 TAACVArgcsegvsftTCSEDGTIRLWDLAfqvnpleanassnpsesstqgimhlasagifERDLVETC-GSKFGFRALA 469
Cdd:COG2319    299 DGKLLA----------SGSDDGTVRLWDLA-------------------------------TGKLLRTLtGHTGAVRSVA 337

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063710352  470 VSEDGKYLAAGDCGGNLHIYDLQESEYTCFMDAHEAEIQSLSFSfpvltnvdseNASSLLASGGKGRAIHIYDVK 544
Cdd:COG2319    338 FSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS----------PDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
49-420 6.06e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 6.06e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352   49 VVVYDVDSCTQSHLVVSHRmpKPLSCVAISQNGRFVAAGESPNlsAVLIWDCDTLGLVSELKGHLYGSQCLSFSPNGEYL 128
Cdd:COG2319    102 VRLWDLATGLLLRTLTGHT--GAVRSVAFSPDGKTLASGSADG--TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLL 177

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  129 VSVG--GYIYLWDWRKSILVAKVKASSNcsEITSVTFSSNGKFIVT-SGNKHLKFWTVGSFQRTR-----SSKVGSLAFH 200
Cdd:COG2319    178 ASGSddGTVRLWDLATGKLLRTLTGHTG--AVRSVAFSPDGKLLASgSADGTVRLWDLATGKLLRtltghSGSVRSVAFS 255

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  201 GNqtddgfqkGNSFVsvisanrvnSSGSDEQI-------DEVISIYALTEAGVLmlmsygmlikkSVdlkvqkcfALSAS 273
Cdd:COG2319    256 PD--------GRLLA---------SGSADGTVrlwdlatGELLRTLTGHSGGVN-----------SV--------AFSPD 299

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  274 SRLIACACSKGMVQLFTPETLDYAGTIQFSDAKssntenlsqspepkniesspgifPDAVAcqFSTTDKLVVIYG-NRSL 352
Cdd:COG2319    300 GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA-----------------------VRSVA--FSPDGKTLASGSdDGTV 354

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063710352  353 YVWDVDDVNKPTRcsmMISHSAGIWDIKnlscgnmHSPTAACVArgcsegvsftTCSEDGTIRLWDLA 420
Cdd:COG2319    355 RLWDLATGELLRT---LTGHTGAVTSVA-------FSPDGRTLA----------SGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 69-418 1.05e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.55  E-value: 1.05e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352   69 PKPLSCVAISQNGRFVAAGeSPNlSAVLIWDCDTLGLVSELKGHLYGSQCLSFSPNGEYLVSVG--GYIYLWDWRKSILV 146
Cdd:cd00200      9 TGGVTCVAFSPDGKLLATG-SGD-GTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSsdKTIRLWDLETGECV 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  147 AKVKASsnCSEITSVTFSSNGKFIVTSG-NKHLKFWTVGSFQrtrssKVGSLAFHgnqTDDGfqkgnSFVSVISANRVNS 225
Cdd:cd00200     87 RTLTGH--TSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGK-----CLTTLRGH---TDWV-----NSVAFSPDGTFVA 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  226 SGSDeqiDEVISIYALTEAGVLMLMsYGMliKKSVdlkvqKCFALSASSRLIACACSKGMVQLFTPETLDYAGTIQFSDA 305
Cdd:cd00200    152 SSSQ---DGTIKLWDLRTGKCVATL-TGH--TGEV-----NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN 220

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  306 KssntenlsqspepkniesspgifpdAVACQFSTTDKLVVIYG-NRSLYVWDVDDvnkpTRCSMMIS-HSAGIWDIknls 383
Cdd:cd00200    221 G-------------------------VNSVAFSPDGYLLASGSeDGTIRVWDLRT----GECVQTLSgHTNSVTSL---- 267

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 1063710352  384 cgnMHSPTAACVArgcsegvsftTCSEDGTIRLWD 418
Cdd:cd00200    268 ---AWSPDGKRLA----------SGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
269-634 7.56e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.36  E-value: 7.56e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  269 ALSASSRLIACACSKGMVQLFTPETLDYAGTIqfsdakssntenlsqspepknieSSPGIFPDAVAcqFSTTDKLVVIYG 348
Cdd:COG2319    127 AFSPDGKTLASGSADGTVRLWDLATGKLLRTL-----------------------TGHSGAVTSVA--FSPDGKLLASGS 181

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  349 -NRSLYVWDVDDVNKPTRcsmMISHSAGIWDiknlscgnmhsptaacvargcsegVSFT-------TCSEDGTIRLWDLA 420
Cdd:COG2319    182 dDGTVRLWDLATGKLLRT---LTGHTGAVRS------------------------VAFSpdgkllaSGSADGTVRLWDLA 234

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  421 fqvnpleanassnpsessTQGIMHLASagiferdlvetcGSKFGFRALAVSEDGKYLAAGDCGGNLHIYDLQESEYTCFM 500
Cdd:COG2319    235 ------------------TGKLLRTLT------------GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  501 DAHEAEIQSLSFSfPvltnvDSEnassLLASGGKGRAIHIYDVKRNfDPVGSVCG-SAAVTSVKFACNGRKMLTSGADR- 578
Cdd:COG2319    285 TGHSGGVNSVAFS-P-----DGK----LLASGSDDGTVRLWDLATG-KLLRTLTGhTGAVRSVAFSPDGKTLASGSDDGt 353

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1063710352  579 LQMFDVNRKASSVRLSpSHTqtlshGTIYDVAVDPTSGLVVTVGQDKKINIFDIES 634
Cdd:COG2319    354 VRLWDLATGELLRTLT-GHT-----GAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
19-185 9.98e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.81  E-value: 9.98e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352   19 QEIIGLTTKNANGLASVTCSSKCVYLAGC----VVVVYDVDSCTQSHLVVSHrmPKPLSCVAISQNGRFVAAGESPNlsA 94
Cdd:COG2319    236 GKLLRTLTGHSGSVRSVAFSPDGRLLASGsadgTVRLWDLATGELLRTLTGH--SGGVNSVAFSPDGKLLASGSDDG--T 311

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352   95 VLIWDCDTLGLVSELKGHLYGSQCLSFSPNGEYLVSVG--GYIYLWDWRKSILVAKVKASSNcsEITSVTFSSNGKFIVT 172
Cdd:COG2319    312 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSddGTVRLWDLATGELLRTLTGHTG--AVTSVAFSPDGRTLAS 389

                          170
                   ....*....|....
gi 1063710352  173 -SGNKHLKFWTVGS 185
Cdd:COG2319    390 gSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 606-729 4.22e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.99  E-value: 4.22e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  606 IYDVAVDPTSGLVVTVGQDKKINIFDIESGKLVRSFKQdrdHGDPV-KVILDPSCNYLVCSYSNRTICFVDFVTGELVAQ 684
Cdd:cd00200     12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG---HTGPVrDVAASADGTYLASGSSDKTIRLWDLETGECVRT 88

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1063710352  685 ATGHGEAVTGVIFLPDCKHIISVASDGCIFVWKLPLRMATRIIRA 729
Cdd:cd00200     89 LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG 133
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 31-203 1.70e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 72.37  E-value: 1.70e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352   31 GLASVTCSSKCVYLAGC----VVVVYDVDSCTQSHLVVSHRmpKPLSCVAISQNGRFVAAgeSPNLSAVLIWDCDTLGLV 106
Cdd:cd00200     53 PVRDVAASADGTYLASGssdkTIRLWDLETGECVRTLTGHT--SYVSSVAFSPDGRILSS--SSRDKTIKVWDVETGKCL 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  107 SELKGHLYGSQCLSFSPNGEYLVSVG--GYIYLWDWRKSILVAKVKASSNcsEITSVTFSSNG-KFIVTSGNKHLKFWTV 183
Cdd:cd00200    129 TTLRGHTDWVNSVAFSPDGTFVASSSqdGTIKLWDLRTGKCVATLTGHTG--EVNSVAFSPDGeKLLSSSSDGTIKLWDL 206

                          170       180
                   ....*....|....*....|....*
gi 1063710352  184 GSFQ-----RTRSSKVGSLAFHGNQ 203
Cdd:cd00200    207 STGKclgtlRGHENGVNSVAFSPDG 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 51-181 4.68e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.13  E-value: 4.68e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352   51 VYDVDSCTQSHLVVSHRMPkpLSCVAISQNGRFVAAGeSPNlSAVLIWDCDTLGLVSELKGHLYGSQCLSFSPNGEYLVS 130
Cdd:cd00200    161 LWDLRTGKCVATLTGHTGE--VNSVAFSPDGEKLLSS-SSD-GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS 236

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1063710352  131 VG--GYIYLWDWRKSILVAKVKASSNcsEITSVTFSSNGKFIVT-SGNKHLKFW 181
Cdd:cd00200    237 GSedGTIRVWDLRTGECVQTLSGHTN--SVTSLAWSPDGKRLASgSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
592-718 8.96e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.61  E-value: 8.96e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  592 RLSPSHTQTLSHGTIYDVAVDPTSGLVVTVGQDKKINIFDIESGKLVRSFkqdRDHGDPVK-VILDPSCNYLVCSYSNRT 670
Cdd:COG2319     25 LGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATL---LGHTAAVLsVAFSPDGRLLASASADGT 101

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1063710352  671 ICFVDFVTGELVAQATGHGEAVTGVIFLPDCKHIISVASDGCIFVWKL 718
Cdd:COG2319    102 VRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
574-711 6.40e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.92  E-value: 6.40e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  574 SGADRLQMFDVNrkassvrlSPSHTQTLSHGT-IYDVAVDPTSG-LVVTVGQDKKINIFDIESGKLVRSFKQDRdhgDPV 651
Cdd:COG3391     87 SGSGRVSVIDLA--------TGKVVATIPVGGgPRGLAVDPDGGrLYVADSGNGRVSVIDTATGKVVATIPVGA---GPH 155

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063710352  652 KVILDPSCNYL-VCSYSNRTICFV----DFVTGELVAQATGhGEAVTGVIFLPDCKHIIsVASDG 711
Cdd:COG3391    156 GIAVDPDGKRLyVANSGSNTVSVIvsviDTATGKVVATIPV-GGGPVGVAVSPDGRRLY-VANRG 218
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 678-717 1.89e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.89e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1063710352   678 TGELVAQATGHGEAVTGVIFLPDCKHIISVASDGCIFVWK 717
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
568-711 1.97e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 44.30  E-value: 1.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  568 GRKMLTSGADRLQMFDVNRKASSVRLSPSHTQTLSHGTIYDVAVDPTSGLVVTVGQDKKINIFDIESGKLVRSFKQDrdh 647
Cdd:COG3391     33 GGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVG--- 109

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063710352  648 GDPVKVILDPSCNYL-VCSYSNRTICFVDFVTGELVAQATGhGEAVTGVIFLPDCKHIIsVASDG 711
Cdd:COG3391    110 GGPRGLAVDPDGGRLyVADSGNGRVSVIDTATGKVVATIPV-GAGPHGIAVDPDGKRLY-VANSG 172
WD40 pfam00400
WD domain, G-beta repeat;
679-716 1.43e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.43e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1063710352  679 GELVAQATGHGEAVTGVIFLPDCKHIISVASDGCIFVW 716
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 102-139 1.83e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.83e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1063710352   102 TLGLVSELKGHLYGSQCLSFSPNGEYLVSVG--GYIYLWD 139
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSddGTIKLWD 40
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 574-699 2.91e-03

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 40.72  E-value: 2.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063710352  574 SGADRLQMFDVNRKASSvRLSPSHTQTLSHGTIYDVAVDPTSGLVVTVGQDKKINIFDIESGKLV---RSFKQdrdhgdP 650
Cdd:cd14961     29 DGNKRIQVFDSDGNCLQ-QFGPKGDAGQDIRYPLDVAVTPDGHIVVTDAGDRSVKVFSFDGRLKLfvrKSFSL------P 101

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1063710352  651 VKVILDPSCNYLVCSYSNRTI-CF-VDFVTGELvaqatGHGEAVTGVIFLP 699
Cdd:cd14961    102 WGVAVNPSGEILVTDSEAGKLfVLtVDFKLGIL-----KKGQKLCSQLCRP 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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