|
Name |
Accession |
Description |
Interval |
E-value |
| PLN03012 |
PLN03012 |
Camelliol C synthase |
1-751 |
0e+00 |
|
Camelliol C synthase
Pssm-ID: 166653 [Multi-domain] Cd Length: 759 Bit Score: 943.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 1 MWRLKLSEGDEE-----SVNQHVGRQFWEYDNQFGTSEERHHINHLRSNFTLNRFSSKHSSDLLYRFQCWKEKgKGMERL 75
Cdd:PLN03012 1 MWKLKIAEGNGDdpylfSTNNFAGRQTWEFDPDAGSPEELAAVEEARRIFYDDRFHVKASSDLIWRMQFLKEK-KFEQRI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 76 PQVKVKEGEErlINEEVVNVTLRRSLRFYSILQSQDGFWPGDYGGPLFLLPALVIGLYVTEVLDGTLTAQHQIEIRRYLY 155
Cdd:PLN03012 80 APAKVEDAEK--ITFEIATNALRKGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDEIFTQDHRKEILRYIY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 156 NHQNKDGGWGLHVEGNSTMFCTVLSYVALRLMGEELDGG-DGAMESARSWIHHHGGATFIPSWGKFWLSVLGAYEWSGNN 234
Cdd:PLN03012 158 CHQKEDGGWGLHIEGHSTMFCTTLNYICMRILGEGPDGGhDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSN 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 235 PLPPELWLLPYSLPFHPGRMWCHCRMVYLPMSYLYGRRFVCRTNGTILSLRRELYTIPYHHIDWDTARNQCAKEDLYYPH 314
Cdd:PLN03012 238 PMPPEFWILPSFFPIHPAKMWCYCRLVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPH 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 315 PKIQDVLWSCLNKFGEPLLERWPLNNL-RNHALQTVMQHIHYEDQNSHYICIGPVNKVLNMLCCWVESSNSEAFKSHLSR 393
Cdd:PLN03012 318 PLIQDLIWDCLYIFAEPFLACWPFNKLlREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGDHFKKHLLR 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 394 IKDYLWVAEDGMKMQGYnGSQLWDVTLAVQAILATNLVDDYGLMLKKAHNYIKNTQIRKDTSGDPGLWYRHPCKGGWGFS 473
Cdd:PLN03012 398 ISDYLWIAEDGMKMQSF-GSQLWDSGFALQALLASNLSNEIPDVLRRGHDFIKNSQVGENPSGDFKNMYRHISKGAWTFS 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 474 TGDNPWPVSDCTAEALKAALLLSQMPVNLVGEPMPEEHLVDAVNFILSLQNKNGGFASYELTRSYPELEVINPSETFGDI 553
Cdd:PLN03012 477 DRDHGWQASDCTAEGFKCCLLFSMIAPDIVGPKMDPEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLELLNPTEMFADI 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 554 IIDYQYVECTSAAIQGLVLFTTLNSSYKRKEIVGSINKAVEFIEKTQLPDGSWYGSWGVCFTYATWFGIKGMLASGKTYE 633
Cdd:PLN03012 557 VIEHEYNECTSSAIQALILFKQLYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFALAGLAAAGKTFN 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 634 SSLCIRKACGFLLSKQLCCGGWGESYLSCQNKVYTNLPGNKSHIVNTSWALLALIEAGQASRDPMPLHRGAKSLINSQME 713
Cdd:PLN03012 637 DCEAIRKGVHFLLAAQKDNGGWGESYLSCPKKIYIAQEGEISNLVQTAWALMGLIHAGQAERDPIPLHRAAKLIINSQLE 716
|
730 740 750
....*....|....*....|....*....|....*...
gi 1063715067 714 DGDYPQQEILGVFNRNCMISYSAYRNIFPIWALGEYRK 751
Cdd:PLN03012 717 NGDFPQQEATGAFLKNCLLHYAAYRNIFPLWALAEYRA 754
|
|
| SQCY_1 |
cd02892 |
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ... |
97-749 |
0e+00 |
|
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.
Pssm-ID: 239222 [Multi-domain] Cd Length: 634 Bit Score: 864.58 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 97 LRRSLRFYSILQSQDGFWPGDYGGPLFLLPALVIGLYVTEVLDgtlTAQHQIEIRRYLYNHQNKDGGWGLHVEGNSTMFC 176
Cdd:cd02892 1 IRRALEFLLSLQAPDGHWPGELEGPLFITAEYILLLYILGIPI---DPEHRKEIARYLRNHQNPDGGWGLHHEGPSTMFG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 177 TVLSYVALRLMGEELDggDGAMESARSWIHHHGGATFIPSWGKFWLSVLGAYEWSGNNPLPPELWLLPYSLPFHPGRMWC 256
Cdd:cd02892 78 TVLNYVALRLLGVSPD--DPHMVKARNWILSHGGAARIPVWGKIWLALLGVYPWEGVPPLPPELWLLPSWLPFHPYKFWC 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 257 HCRMVYLPMSYLYGRRFVCRTNGTILSLRRELYTIPYHHIDWDTARNqcAKEDLYYPHPKIQDVLWSCLNKFgepllERW 336
Cdd:cd02892 156 WARTVYVPMSYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRN--DLYDYRPPWQRLFDALDRLLHWY-----EPL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 337 PLNNLRNHALQTVMQHIHYEDQNSHYICIGPVNKVLNMLCCWVES-SNSEAFKSHLSRIKDYLWVAEDGMKMQGYNGSQL 415
Cdd:cd02892 229 PPKPLRRKALRKAYEWILYRDENTGYLGIIPPPKANNMLALWVLGyPDSPAFKRHLERIDDFLWLGPEGMKMCQTNGSQV 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 416 WDVTLAVQAILATNLVDDYGLMLKKAHNYIKNTQIRkDTSGDPGLWYRHPCKGGWGFSTGDNPWPVSDCTAEALKAALLL 495
Cdd:cd02892 309 WDTALAVQALLEAGLAPEFDPALKKALDWLLESQIL-DNPGDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKALLRL 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 496 SQMPVNlvGEPMPEEHLVDAVNFILSLQNKNGGFASYELTRSYPELEVINPSETFGDIIIDYQYVECTSAAIQGLVLFTT 575
Cdd:cd02892 388 QELPPF--GEKVSRERLYDAVDWLLGMQNSNGGFAAFEPDNTYHWLENLNPFEDFGDIMIDPPYVECTGSVLEALGLFGK 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 576 LNSSYkRKEIVGSINKAVEFIEKTQLPDGSWYGSWGVCFTYATWFGIKGMLASGKTYESSLCIRKACGFLLSKQLCCGGW 655
Cdd:cd02892 466 LYPGH-RREIDPAIRRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEALAAAGEDYENSPYIRKACDFLLSKQNPDGGW 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 656 GESYLSCQNKVYtnLPGNKSHIVNTSWALLALIEAGQAsrDPMPLHRGAKSLINSQMEDGDYPQQEILGVFNRNCMISYS 735
Cdd:cd02892 545 GESYLSYEDKSY--AGGGRSTVVQTAWALLALMAAGEP--DSEAVERGIKYLLNTQLPDGDWPQEEITGVGFPNFYIRYH 620
|
650
....*....|....
gi 1063715067 736 AYRNIFPIWALGEY 749
Cdd:cd02892 621 NYRNYFPLWALGRY 634
|
|
| squalene_cyclas |
TIGR01787 |
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ... |
96-751 |
0e+00 |
|
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.
Pssm-ID: 273809 [Multi-domain] Cd Length: 621 Bit Score: 699.58 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 96 TLRRSLRFYSILQSQDGFWPGDYGGPLFLLPALVIGLYVTevldGTLTAQHQIEIRRYLYNHQNKDGGWGLHVEGNSTMF 175
Cdd:TIGR01787 1 TARRAVEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIA----DTPLPGYREKIVRYLRHHQNEDGGWGLHIGGKSTVF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 176 CTVLSYVALRLMGEELDggDGAMESARSWIHHHGGATFIPSWGKFWLSVLGAYEWSGNNPLPPELWLLPYSLPFHPGRMW 255
Cdd:TIGR01787 77 GTVLAYVALKILGMSPD--DPAMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSKSW 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 256 CHCRMVYLPMSYLYGRRFVCRtngtiLSLRRELYTIPyhhIDWDTARNQCAKEDLYYPHPKIQDVLWSCLNKFGEPLLER 335
Cdd:TIGR01787 155 CRCRMVYLPMSYCYGERLSAP-----IDPREELYVED---DSIRAQRNNVAKEDLYTPHSWLLRALYGLLNLFYHPFLRK 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 336 WplnnLRNHALQTVMQHIHYEDqnshyiCIGPVNKVLNMLCCW-VESSNSEAFKSHLSRIKDYLWVAEDGMKMQGYnGSQ 414
Cdd:TIGR01787 227 A----LRKRALQWLYEHIAADG------SIGPISKAMAMLALWfLDGPNSPAFQKHLQRIDDYLWLQLDGMKMQGT-GSQ 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 415 LWDVTLAVQAILATNLV--DDYGLMLKKAHNYIKNTQIRKDTSGDPGLwYRHPCK-GGWGFSTGDNPWP-VSDCTAEALK 490
Cdd:TIGR01787 296 VWDTAFAIQALRESGDHrlPEFHPALVKAHEWLLLSQIPDNPPGDWKV-YRHNLKpGGWAFSFLNCGYPdVDDTAVVALK 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 491 AALLLSQMpvnlvgEPMPEEHLVDAVNFILSLQNKNGGFASYELTRSYPELEVINPSETFGDIIIDYQYVECTSAAIQGL 570
Cdd:TIGR01787 375 AVLLLQED------EHVKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGDIMIDPPYVDVTARVIQAL 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 571 VLFTtlnssYKRKEIVGSINKAVEFIEKTQLPDGSWYGSWGVCFTYATWFGIKGMLASGKTYESSLCIRKACGFLLSKQL 650
Cdd:TIGR01787 449 GAFG-----HRADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTYRNCPEVQKACDWLLSRQM 523
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 651 CCGGWGESYLSCQNKVYTnlPGNKSHIVNTSWALLALIEAGQASRDpmPLHRGAKSLINSQMEDGDYPQQEILGVFN-RN 729
Cdd:TIGR01787 524 PDGGWGEDCFSYEDPSYV--GSGGSTPSQTGWALMALIAAGEADSE--AIERGVKYLLETQRPDGDWPQEYITGVGFpKN 599
|
650 660
....*....|....*....|..
gi 1063715067 730 CMISYSAYRNIFPIWALGEYRK 751
Cdd:TIGR01787 600 FYLKYTNYRNIFPLWALGRYRQ 621
|
|
| SqhC |
COG1657 |
Terpene cyclase SqhC [Lipid transport and metabolism]; |
96-753 |
3.41e-172 |
|
Terpene cyclase SqhC [Lipid transport and metabolism];
Pssm-ID: 441263 [Multi-domain] Cd Length: 644 Bit Score: 509.36 E-value: 3.41e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 96 TLRRSLRFYSILQSQDGFWPGDYGGPLFLLPALVIGLYVtevLDGTLTAQHQIEIRRYLYNHQNKDGGWGLHVEGNSTMF 175
Cdd:COG1657 23 AAIAAAQALLLQQQDDGGWWGGELEADVTIAAEYILLHH---FLGPDDEELEAKIARYLRRQQNDDGGWPLYHGGPGDLS 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 176 CTVLSYVALRLMGEELDggDGAMESARSWIHHHGGATFIPSWGKFWLSVLGAYEWSGNNplppelwllpySLP------- 248
Cdd:COG1657 100 TTVKAYFALKLLGDDPD--APHMVRAREFILARGGAARANVFTKIWLALFGQYPWRGVP-----------ALPpeimllp 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 249 ----FHPGRMWCHCRMVYLPMSYLYGRRFVCRTNGTIlsLRRELYTIPYHHIDWDTARNQcakedlyyPHPKIQDVLWSc 324
Cdd:COG1657 167 rwfpFHIYKFSYWARTVIVPLLILYARKPVAPLPPGV--GIDELFVEPPEQVDYYFPAPR--------DRSPWSRFFLA- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 325 LNKFGEpLLERWPLNNLRNHALQTVMQHIHYEDQNS-HYICIGP-VNKVLNMLCCWVESSNSEAFKSHLSRIKDYLWVAE 402
Cdd:COG1657 236 LDRLLR-AYERLPPKPLRRRALRKAEDWILERLEGDgGLGGIFPaMVNSLMALLALGYPPDHPVVRRALEALEKLLVETE 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 403 DGMKMQGyNGSQLWDVTLAVQAILATNLVDDYGlMLKKAHNYIKNTQIRkdtsgDPGLW---YRHPCKGGWGFSTGDNPW 479
Cdd:COG1657 315 DGARCQP-CVSPVWDTALAVQALQEAGLPEDHP-ALERAADWLLSKQIL-----VKGDWavkRPDVEPGGWAFQFANDHY 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 480 PVSDCTAEALKAALLlsqmpVNLVGEPMPEEHLVDAVNFILSLQNKNGGFASYELTRSYPELEVINPSEtFGdIIIDYQY 559
Cdd:COG1657 388 PDVDDTAVVLMALLR-----LRLPDEPRYREAIERAVEWILGMQSRDGGWGAFDKDNTKEWLNKIPFAD-HG-ALLDPPT 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 560 VECTSAAIQGLvlfttlnSSYKRKEIVGSINKAVEFIEKTQLPDGSWYGSWGVCFTYATWFGIKGMLASGKTYESSLcIR 639
Cdd:COG1657 461 ADVTARCLEML-------GQLGLTEDHPAIRRAVAYLRREQEPDGSWFGRWGVNYIYGTWSVLTGLNAAGVDPDDPA-IR 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 640 KACGFLLSKQLCCGGWGESYLSCQNKVYTNLPgnKSHIVNTSWALLALIEAGQASRDpmPLHRGAKSLINSQMEDGDYPQ 719
Cdd:COG1657 533 RAVAWLLSIQNADGGWGEDCRSYEDPRYVGLG--PSTASQTAWALLALLAAGEADSP--AVARGIAYLLSTQREDGSWDE 608
|
650 660 670
....*....|....*....|....*....|....*
gi 1063715067 720 QEILGV-FNRNCMISYSAYRNIFPIWALGEYRKLM 753
Cdd:COG1657 609 EYFTGTgFPRVFYLRYHLYRQYFPLWALARYRNLR 643
|
|
| SQHop_cyclase_C |
pfam13243 |
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ... |
413-751 |
1.38e-42 |
|
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the C-terminal half of the molecule.
Pssm-ID: 433057 [Multi-domain] Cd Length: 319 Bit Score: 157.11 E-value: 1.38e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 413 SQLWDVTLAVQAILATNlVDDYGLMLKKAHNYIKNTQIRkdtsgDPGLWY---RHPCKGGWGFSTgDNPW-PVSDCTAEA 488
Cdd:pfam13243 2 SPVWDTALALHALLEAG-VPADHPALVKAAQWLLDRQVL-----VKGDWAvkrPDLEPGGWAFQF-ANDHyPDVDDTAVV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 489 LKAALLlsqmpVNLVGEPMPEEHLVDAVNFILSLQNKNGGFASYELTRSYpelEVIN--PsetFGDI--IIDYqyvecTS 564
Cdd:pfam13243 75 VLALDR-----VRLPDERRRDDAIARGIEWILGMQSKNGGWGAFDKDNTK---YYLNkiP---FADHgaLLDP-----PT 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 565 AAIQGLVLFTTLNSSYKRKEIVgsINKAVEFIEKTQLPDGSWYGSWGVCFTYATWFGIKGMLASGKTYESSLcIRKACGF 644
Cdd:pfam13243 139 ADVTARVLEMLGQLGYPDDHPV--AARALEYLKKEQEPDGSWFGRWGVNYIYGTWSVLCGLAAVGEDHNRPY-IRKAVDW 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 645 LLSKQLCCGGWGEsylSCQNKVYTNLPG-NKSHIVNTSWALLALIEAGQASRDpmPLHRGAKSLINSQMEDGDYPQQEIL 723
Cdd:pfam13243 216 LKSRQNPDGGWGE---DCESYKDPKLAGrGPSTASQTAWALLALMAAGEVDSP--AVRRGIQYLLETQKPDGTWDEPYFT 290
|
330 340
....*....|....*....|....*....
gi 1063715067 724 GV-FNRNCMISYSAYRNIFPIWALGEYRK 751
Cdd:pfam13243 291 GTgFPRVFYLKYHGYRNYFPLWALARYRN 319
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN03012 |
PLN03012 |
Camelliol C synthase |
1-751 |
0e+00 |
|
Camelliol C synthase
Pssm-ID: 166653 [Multi-domain] Cd Length: 759 Bit Score: 943.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 1 MWRLKLSEGDEE-----SVNQHVGRQFWEYDNQFGTSEERHHINHLRSNFTLNRFSSKHSSDLLYRFQCWKEKgKGMERL 75
Cdd:PLN03012 1 MWKLKIAEGNGDdpylfSTNNFAGRQTWEFDPDAGSPEELAAVEEARRIFYDDRFHVKASSDLIWRMQFLKEK-KFEQRI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 76 PQVKVKEGEErlINEEVVNVTLRRSLRFYSILQSQDGFWPGDYGGPLFLLPALVIGLYVTEVLDGTLTAQHQIEIRRYLY 155
Cdd:PLN03012 80 APAKVEDAEK--ITFEIATNALRKGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDEIFTQDHRKEILRYIY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 156 NHQNKDGGWGLHVEGNSTMFCTVLSYVALRLMGEELDGG-DGAMESARSWIHHHGGATFIPSWGKFWLSVLGAYEWSGNN 234
Cdd:PLN03012 158 CHQKEDGGWGLHIEGHSTMFCTTLNYICMRILGEGPDGGhDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSN 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 235 PLPPELWLLPYSLPFHPGRMWCHCRMVYLPMSYLYGRRFVCRTNGTILSLRRELYTIPYHHIDWDTARNQCAKEDLYYPH 314
Cdd:PLN03012 238 PMPPEFWILPSFFPIHPAKMWCYCRLVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPH 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 315 PKIQDVLWSCLNKFGEPLLERWPLNNL-RNHALQTVMQHIHYEDQNSHYICIGPVNKVLNMLCCWVESSNSEAFKSHLSR 393
Cdd:PLN03012 318 PLIQDLIWDCLYIFAEPFLACWPFNKLlREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGDHFKKHLLR 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 394 IKDYLWVAEDGMKMQGYnGSQLWDVTLAVQAILATNLVDDYGLMLKKAHNYIKNTQIRKDTSGDPGLWYRHPCKGGWGFS 473
Cdd:PLN03012 398 ISDYLWIAEDGMKMQSF-GSQLWDSGFALQALLASNLSNEIPDVLRRGHDFIKNSQVGENPSGDFKNMYRHISKGAWTFS 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 474 TGDNPWPVSDCTAEALKAALLLSQMPVNLVGEPMPEEHLVDAVNFILSLQNKNGGFASYELTRSYPELEVINPSETFGDI 553
Cdd:PLN03012 477 DRDHGWQASDCTAEGFKCCLLFSMIAPDIVGPKMDPEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLELLNPTEMFADI 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 554 IIDYQYVECTSAAIQGLVLFTTLNSSYKRKEIVGSINKAVEFIEKTQLPDGSWYGSWGVCFTYATWFGIKGMLASGKTYE 633
Cdd:PLN03012 557 VIEHEYNECTSSAIQALILFKQLYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFALAGLAAAGKTFN 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 634 SSLCIRKACGFLLSKQLCCGGWGESYLSCQNKVYTNLPGNKSHIVNTSWALLALIEAGQASRDPMPLHRGAKSLINSQME 713
Cdd:PLN03012 637 DCEAIRKGVHFLLAAQKDNGGWGESYLSCPKKIYIAQEGEISNLVQTAWALMGLIHAGQAERDPIPLHRAAKLIINSQLE 716
|
730 740 750
....*....|....*....|....*....|....*...
gi 1063715067 714 DGDYPQQEILGVFNRNCMISYSAYRNIFPIWALGEYRK 751
Cdd:PLN03012 717 NGDFPQQEATGAFLKNCLLHYAAYRNIFPLWALAEYRA 754
|
|
| PLN02993 |
PLN02993 |
lupeol synthase |
1-751 |
0e+00 |
|
lupeol synthase
Pssm-ID: 215537 [Multi-domain] Cd Length: 763 Bit Score: 925.85 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 1 MWRLKLSEGDEE-----SVNQHVGRQFWEYDNQFGTSEERHHINHLRSNFTLNRFSSKHSSDLLYRFQCWKEKgKGMERL 75
Cdd:PLN02993 1 MWKLKIGEGNGEdpylfSSNNFVGRQTWEFDPKAGTPEERAAVEEARRSFLDNRSRVKGCSDLLWRMQFLKEA-KFEQVI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 76 PQVKVKEGEErlINEEVVNVTLRRSLRFYSILQSQDGFWPGDYGGPLFLLPALVIGLYVTEVLDGTLTAQHQIEIRRYLY 155
Cdd:PLN02993 80 PPVKIDRGEE--ITYETATNALRRGVSFFSALQASDGHWPGEITGPLFFLPPLVFCLYITGHLEEVFDAEHRKEMLRHIY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 156 NHQNKDGGWGLHVEGNSTMFCTVLSYVALRLMGEELDGG-DGAMESARSWIHHHGGATFIPSWGKFWLSVLGAYEWSGNN 234
Cdd:PLN02993 158 CHQNEDGGWGLHIESKSVMFCTVLNYICLRMLGEGPNGGrENACKRARQWILDHGGVTYIPSWGKFWLSILGIYDWSGTN 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 235 PLPPELWLLPYSLPFHPGRMWCHCRMVYLPMSYLYGRRFVCRTNGTILSLRRELYTIPYHHIDWDTARNQCAKEDLYYPH 314
Cdd:PLN02993 238 PMPPEIWLLPSFLPIHLGKTLCYTRMVYMPMSYLYGKRFVGPITPLIMLLREELHLQPYEEINWNKARRLCAKEDMYYPH 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 315 PKIQDVLWSCLNKFGEPLLERWPLNNL-RNHALQTVMQHIHYEDQNSHYICIGPVNKVLNMLCCWVESSNSEAFKSHLSR 393
Cdd:PLN02993 318 PLVQDLIWDTLHNFVEPFLTRWPLNKLvREKALQVAMKHIHYEDENSHYITIGCVEKVLCMLACWIENPNGDHFKKHLAR 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 394 IKDYLWVAEDGMKMQGYnGSQLWDVTLAVQAILATNLVDDYGLMLKKAHNYIKNTQIRKDTSGDPGLWYRHPCKGGWGFS 473
Cdd:PLN02993 398 IPDYMWVAEDGMKMQSF-GSQLWDTGFAIQALLASDLSDETDDVLRRGHNYIKKSQVRENPSGDFKSMYRHISKGAWTLS 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 474 TGDNPWPVSDCTAEALKAALLLSQMPVNLVGEPMPEEHLVDAVNFILSLQNKNGGFASYELTRSYPELEVINPSETFGDI 553
Cdd:PLN02993 477 DRDHGWQVSDCTAEALKCCMLLSMMPADVVGQKIDPEQLYDSVNLLLSLQSENGGVTAWEPVRAYKWLELLNPTDFFANT 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 554 IIDYQYVECTSAAIQGLVLFTTLNSSYKRKEIVGSINKAVEFIEKTQLPDGSWYGSWGVCFTYATWFGIKGMLASGKTYE 633
Cdd:PLN02993 557 MVEREYVECTSAVIQALVLFKQLYPDHRTKEIIKSIEKAVQFIESKQTPDGSWYGNWGICFIYATWFALGGLAAAGKTYN 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 634 SSLCIRKACGFLLSKQLCCGGWGESYLSCQNKVYTNLPGNKSHIVNTSWALLALIEAGQASRDPMPLHRGAKSLINSQME 713
Cdd:PLN02993 637 DCLAMRKGVHFLLTIQRDDGGWGESYLSCPEQRYIPLEGNRSNLVQTAWAMMGLIHAGQAERDLIPLHRAAKLIITSQLE 716
|
730 740 750
....*....|....*....|....*....|....*...
gi 1063715067 714 DGDYPQQEILGVFNRNCMISYSAYRNIFPIWALGEYRK 751
Cdd:PLN02993 717 NGDFPQQEILGAFMNTCMLHYATYRNTFPLWALAEYRK 754
|
|
| SQCY_1 |
cd02892 |
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ... |
97-749 |
0e+00 |
|
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.
Pssm-ID: 239222 [Multi-domain] Cd Length: 634 Bit Score: 864.58 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 97 LRRSLRFYSILQSQDGFWPGDYGGPLFLLPALVIGLYVTEVLDgtlTAQHQIEIRRYLYNHQNKDGGWGLHVEGNSTMFC 176
Cdd:cd02892 1 IRRALEFLLSLQAPDGHWPGELEGPLFITAEYILLLYILGIPI---DPEHRKEIARYLRNHQNPDGGWGLHHEGPSTMFG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 177 TVLSYVALRLMGEELDggDGAMESARSWIHHHGGATFIPSWGKFWLSVLGAYEWSGNNPLPPELWLLPYSLPFHPGRMWC 256
Cdd:cd02892 78 TVLNYVALRLLGVSPD--DPHMVKARNWILSHGGAARIPVWGKIWLALLGVYPWEGVPPLPPELWLLPSWLPFHPYKFWC 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 257 HCRMVYLPMSYLYGRRFVCRTNGTILSLRRELYTIPYHHIDWDTARNqcAKEDLYYPHPKIQDVLWSCLNKFgepllERW 336
Cdd:cd02892 156 WARTVYVPMSYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRN--DLYDYRPPWQRLFDALDRLLHWY-----EPL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 337 PLNNLRNHALQTVMQHIHYEDQNSHYICIGPVNKVLNMLCCWVES-SNSEAFKSHLSRIKDYLWVAEDGMKMQGYNGSQL 415
Cdd:cd02892 229 PPKPLRRKALRKAYEWILYRDENTGYLGIIPPPKANNMLALWVLGyPDSPAFKRHLERIDDFLWLGPEGMKMCQTNGSQV 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 416 WDVTLAVQAILATNLVDDYGLMLKKAHNYIKNTQIRkDTSGDPGLWYRHPCKGGWGFSTGDNPWPVSDCTAEALKAALLL 495
Cdd:cd02892 309 WDTALAVQALLEAGLAPEFDPALKKALDWLLESQIL-DNPGDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKALLRL 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 496 SQMPVNlvGEPMPEEHLVDAVNFILSLQNKNGGFASYELTRSYPELEVINPSETFGDIIIDYQYVECTSAAIQGLVLFTT 575
Cdd:cd02892 388 QELPPF--GEKVSRERLYDAVDWLLGMQNSNGGFAAFEPDNTYHWLENLNPFEDFGDIMIDPPYVECTGSVLEALGLFGK 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 576 LNSSYkRKEIVGSINKAVEFIEKTQLPDGSWYGSWGVCFTYATWFGIKGMLASGKTYESSLCIRKACGFLLSKQLCCGGW 655
Cdd:cd02892 466 LYPGH-RREIDPAIRRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEALAAAGEDYENSPYIRKACDFLLSKQNPDGGW 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 656 GESYLSCQNKVYtnLPGNKSHIVNTSWALLALIEAGQAsrDPMPLHRGAKSLINSQMEDGDYPQQEILGVFNRNCMISYS 735
Cdd:cd02892 545 GESYLSYEDKSY--AGGGRSTVVQTAWALLALMAAGEP--DSEAVERGIKYLLNTQLPDGDWPQEEITGVGFPNFYIRYH 620
|
650
....*....|....
gi 1063715067 736 AYRNIFPIWALGEY 749
Cdd:cd02892 621 NYRNYFPLWALGRY 634
|
|
| squalene_cyclas |
TIGR01787 |
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ... |
96-751 |
0e+00 |
|
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.
Pssm-ID: 273809 [Multi-domain] Cd Length: 621 Bit Score: 699.58 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 96 TLRRSLRFYSILQSQDGFWPGDYGGPLFLLPALVIGLYVTevldGTLTAQHQIEIRRYLYNHQNKDGGWGLHVEGNSTMF 175
Cdd:TIGR01787 1 TARRAVEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIA----DTPLPGYREKIVRYLRHHQNEDGGWGLHIGGKSTVF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 176 CTVLSYVALRLMGEELDggDGAMESARSWIHHHGGATFIPSWGKFWLSVLGAYEWSGNNPLPPELWLLPYSLPFHPGRMW 255
Cdd:TIGR01787 77 GTVLAYVALKILGMSPD--DPAMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSKSW 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 256 CHCRMVYLPMSYLYGRRFVCRtngtiLSLRRELYTIPyhhIDWDTARNQCAKEDLYYPHPKIQDVLWSCLNKFGEPLLER 335
Cdd:TIGR01787 155 CRCRMVYLPMSYCYGERLSAP-----IDPREELYVED---DSIRAQRNNVAKEDLYTPHSWLLRALYGLLNLFYHPFLRK 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 336 WplnnLRNHALQTVMQHIHYEDqnshyiCIGPVNKVLNMLCCW-VESSNSEAFKSHLSRIKDYLWVAEDGMKMQGYnGSQ 414
Cdd:TIGR01787 227 A----LRKRALQWLYEHIAADG------SIGPISKAMAMLALWfLDGPNSPAFQKHLQRIDDYLWLQLDGMKMQGT-GSQ 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 415 LWDVTLAVQAILATNLV--DDYGLMLKKAHNYIKNTQIRKDTSGDPGLwYRHPCK-GGWGFSTGDNPWP-VSDCTAEALK 490
Cdd:TIGR01787 296 VWDTAFAIQALRESGDHrlPEFHPALVKAHEWLLLSQIPDNPPGDWKV-YRHNLKpGGWAFSFLNCGYPdVDDTAVVALK 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 491 AALLLSQMpvnlvgEPMPEEHLVDAVNFILSLQNKNGGFASYELTRSYPELEVINPSETFGDIIIDYQYVECTSAAIQGL 570
Cdd:TIGR01787 375 AVLLLQED------EHVKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGDIMIDPPYVDVTARVIQAL 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 571 VLFTtlnssYKRKEIVGSINKAVEFIEKTQLPDGSWYGSWGVCFTYATWFGIKGMLASGKTYESSLCIRKACGFLLSKQL 650
Cdd:TIGR01787 449 GAFG-----HRADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTYRNCPEVQKACDWLLSRQM 523
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 651 CCGGWGESYLSCQNKVYTnlPGNKSHIVNTSWALLALIEAGQASRDpmPLHRGAKSLINSQMEDGDYPQQEILGVFN-RN 729
Cdd:TIGR01787 524 PDGGWGEDCFSYEDPSYV--GSGGSTPSQTGWALMALIAAGEADSE--AIERGVKYLLETQRPDGDWPQEYITGVGFpKN 599
|
650 660
....*....|....*....|..
gi 1063715067 730 CMISYSAYRNIFPIWALGEYRK 751
Cdd:TIGR01787 600 FYLKYTNYRNIFPLWALGRYRQ 621
|
|
| osq_cycl |
TIGR03463 |
2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella ... |
107-749 |
0e+00 |
|
2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella aurantiaca which produces cycloartenol, and Gemmata obscuriglobus and Methylococcus capsulatus, which each produce the closely related sterol, lanosterol.
Pssm-ID: 274591 [Multi-domain] Cd Length: 634 Bit Score: 572.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 107 LQSQDGFWPGDYGGPLFLLPALVIGLYVtevLDGTLTAQHQIEIRRYLYNHQNKDGGWGLHVEGNSTMFCTVLSYVALRL 186
Cdd:TIGR03463 4 LQDSAGDWEGDMGGCQFIIAIAVAGLHV---MGRPPDAEERAAIIAHFELHQLADGAWGLDPEAPGQVFFSVLAYVALRL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 187 MGeeLDGGDGAMESARSWIH-HHGGATFIPSWGKFWLSVLGAYEWSGNNPLPPELWLLPYSLPFHPGRMWCHCRMVYLPM 265
Cdd:TIGR03463 81 LG--LGKDDAGLARARAWFHaQPEGPKASGAWGKFILALLGLYEREGLNAVPPELFLLPESLPFHPSRFWCHCRLIYLGI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 266 SYLYGRRFVCRTNGTIL-SLRRELYTIPYHHIDWDTARNQCAKEDLYYPHPKIQDVLWSCLNKFgepllERWPLNNLRNH 344
Cdd:TIGR03463 159 AWLSGRGARAPESDPLLaAIRQEIFAEGYEQVDFGAARERVAPTDLFTPISFVLKAANDLLAGY-----ERLAGKALRAR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 345 ALQTVMQHIHYEDQNSHYICIGPVNKVLNMLCCWVESSNSEAFKSHLSRIKDYLWVAED-GMKMQGYNGSQLWDVTLAVQ 423
Cdd:TIGR03463 234 ALDFAFEQILAEDEATHYICIGPINGLLNCLAIFAHDPDGPDLAAHLEGLEAWFWEDDAeGLRMNGANSNALWDTAFAVQ 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 424 AILAT-NLVDDYGLMLKKAHNYIKNTQIRKDTSgDPGLWYRHPCKGGWGFSTGDNPWPVSDCTAEALKAALLLSQMPVNL 502
Cdd:TIGR03463 314 ALAALgELDEEAKHALEEAAAFIDAAQMLADLA-DPQEAFRDPAKGGWCFSDGDHCWPISDCAAEALKALFALEELGDNR 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 503 VGEPMPEEHLVDAVNFILSLQNKNGGFASYELTRSYPELEVINPSETFGDIIIDYQYVECTSAAIQGLVLFTTLNSSYKR 582
Cdd:TIGR03463 393 ISEALGAARLQDAVEFILSMQNADGGFATYELQRGGKLLELLNPSDMFGQCMTDLSYVECTAACLGALAAWLKHHPDLPD 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 583 KEIVGSINKAVEFIEKTQLPDGSWYGSWGVCFTYATWFGIKGMLASGKTyESSLCIRKACGFLLSKQLCCGGWGESYLSC 662
Cdd:TIGR03463 473 AKIDAAIRKAEEFIRRRQLDDGSFMGFWGICFTYATFFGAKGLIAAGAE-PADMALQAAAAFLLEKQRADGAWGEHVESC 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 663 QNKVYtnLPGNKSHIVNTSWALLALIEAGQASRDPMplHRGAKSLINSQMEDGDYPQQEILGVFNRNCMISYSAYRNIFP 742
Cdd:TIGR03463 552 LEARW--VEGKHGHAVMTAWALLALAAAGEAAHDAA--ERGIAWLCEQQGEDGGWPPEGIAGIFFGAAAIDYDAYLRIFP 627
|
....*..
gi 1063715067 743 IWALGEY 749
Cdd:TIGR03463 628 TWALARC 634
|
|
| SqhC |
COG1657 |
Terpene cyclase SqhC [Lipid transport and metabolism]; |
96-753 |
3.41e-172 |
|
Terpene cyclase SqhC [Lipid transport and metabolism];
Pssm-ID: 441263 [Multi-domain] Cd Length: 644 Bit Score: 509.36 E-value: 3.41e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 96 TLRRSLRFYSILQSQDGFWPGDYGGPLFLLPALVIGLYVtevLDGTLTAQHQIEIRRYLYNHQNKDGGWGLHVEGNSTMF 175
Cdd:COG1657 23 AAIAAAQALLLQQQDDGGWWGGELEADVTIAAEYILLHH---FLGPDDEELEAKIARYLRRQQNDDGGWPLYHGGPGDLS 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 176 CTVLSYVALRLMGEELDggDGAMESARSWIHHHGGATFIPSWGKFWLSVLGAYEWSGNNplppelwllpySLP------- 248
Cdd:COG1657 100 TTVKAYFALKLLGDDPD--APHMVRAREFILARGGAARANVFTKIWLALFGQYPWRGVP-----------ALPpeimllp 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 249 ----FHPGRMWCHCRMVYLPMSYLYGRRFVCRTNGTIlsLRRELYTIPYHHIDWDTARNQcakedlyyPHPKIQDVLWSc 324
Cdd:COG1657 167 rwfpFHIYKFSYWARTVIVPLLILYARKPVAPLPPGV--GIDELFVEPPEQVDYYFPAPR--------DRSPWSRFFLA- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 325 LNKFGEpLLERWPLNNLRNHALQTVMQHIHYEDQNS-HYICIGP-VNKVLNMLCCWVESSNSEAFKSHLSRIKDYLWVAE 402
Cdd:COG1657 236 LDRLLR-AYERLPPKPLRRRALRKAEDWILERLEGDgGLGGIFPaMVNSLMALLALGYPPDHPVVRRALEALEKLLVETE 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 403 DGMKMQGyNGSQLWDVTLAVQAILATNLVDDYGlMLKKAHNYIKNTQIRkdtsgDPGLW---YRHPCKGGWGFSTGDNPW 479
Cdd:COG1657 315 DGARCQP-CVSPVWDTALAVQALQEAGLPEDHP-ALERAADWLLSKQIL-----VKGDWavkRPDVEPGGWAFQFANDHY 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 480 PVSDCTAEALKAALLlsqmpVNLVGEPMPEEHLVDAVNFILSLQNKNGGFASYELTRSYPELEVINPSEtFGdIIIDYQY 559
Cdd:COG1657 388 PDVDDTAVVLMALLR-----LRLPDEPRYREAIERAVEWILGMQSRDGGWGAFDKDNTKEWLNKIPFAD-HG-ALLDPPT 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 560 VECTSAAIQGLvlfttlnSSYKRKEIVGSINKAVEFIEKTQLPDGSWYGSWGVCFTYATWFGIKGMLASGKTYESSLcIR 639
Cdd:COG1657 461 ADVTARCLEML-------GQLGLTEDHPAIRRAVAYLRREQEPDGSWFGRWGVNYIYGTWSVLTGLNAAGVDPDDPA-IR 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 640 KACGFLLSKQLCCGGWGESYLSCQNKVYTNLPgnKSHIVNTSWALLALIEAGQASRDpmPLHRGAKSLINSQMEDGDYPQ 719
Cdd:COG1657 533 RAVAWLLSIQNADGGWGEDCRSYEDPRYVGLG--PSTASQTAWALLALLAAGEADSP--AVARGIAYLLSTQREDGSWDE 608
|
650 660 670
....*....|....*....|....*....|....*
gi 1063715067 720 QEILGV-FNRNCMISYSAYRNIFPIWALGEYRKLM 753
Cdd:COG1657 609 EYFTGTgFPRVFYLRYHLYRQYFPLWALARYRNLR 643
|
|
| SQCY |
cd02889 |
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ... |
410-749 |
7.53e-141 |
|
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.
Pssm-ID: 239219 [Multi-domain] Cd Length: 348 Bit Score: 417.78 E-value: 7.53e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 410 YNGSQLWDVTLAVQAILATNLVDDYGLMLKKAHNYIKNTQIRKDTsGDPGLWYRHPCKGGWGFSTGDNPWPVSDCTAEAL 489
Cdd:cd02889 20 GEYSQVWDTALALQALLEAGLAPEFDPALKKALEWLLKSQIRDNP-DDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEAL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 490 KAALLLSQMPVNlvGEPMPEEHLVDAVNFILSLQNKNGGFASYELTRSYPELEVinPSETFGDIIIDYQYVECTSAAIQG 569
Cdd:cd02889 99 KALLRLQKKPPD--GKKVSRERLYDAVDWLLSMQNSNGGFAAFEPDNTYKYLEL--IPEVDGDIMIDPPYVECTGSVLEA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 570 LVLFTTLNSSYkRKEIVGSINKAVEFIEKTQLPDGSWYGSWGVCFTYATWFGIKGMLASGKTyESSLCIRKACGFLLSKQ 649
Cdd:cd02889 175 LGLFGKLYPEH-RREIDPAIRRAVKYLEREQEPDGSWYGRWGVCFIYGTWFALEALAAAGED-ENSPYVRKACDWLLSKQ 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 650 LCCGGWGESYLSCQNKVYTNlpGNKSHIVNTSWALLALIEAGQAsrDPMPLHRGAKSLINSQMEDGDYPQQEILGVFNRN 729
Cdd:cd02889 253 NPDGGWGESYESYEDPSYAG--GGRSTVVQTAWALLALMAAGEP--DSEAVKRGVKYLLNTQQEDGDWPQEEITGVFFKN 328
|
330 340
....*....|....*....|
gi 1063715067 730 CMISYSAYRNIFPIWALGEY 749
Cdd:cd02889 329 FYIRYHNYRNYFPLWALGRY 348
|
|
| hopene_cyclase |
TIGR01507 |
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) ... |
97-752 |
5.92e-54 |
|
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) biosynthesis. Squalene hopene cyclase, an integral membrane protein, directly cyclizes squalene into hopanoid products. [Fatty acid and phospholipid metabolism, Other]
Pssm-ID: 273661 [Multi-domain] Cd Length: 635 Bit Score: 197.03 E-value: 5.92e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 97 LRRSLRFYSILQSQDGFWPGDYGGPLfLLPALVIGLYvtEVLDgTLTAQHQIEIRRYLYNHQNKDGGWGLHVEGNSTMFC 176
Cdd:TIGR01507 18 IDRAVDYLLSCQKDEGYWWGELESNV-TIEAEYVLLC--HILD-RVDRDRMEKIRNYLLHEQREDGTWALYPGGPGDLST 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 177 TVLSYVALRLMGEELDggDGAMESARSWIHHHGGATFIPSWGKFWLSVLGAYEWSGNNPLPPELWLLPYSLPFHPGRMWC 256
Cdd:TIGR01507 94 TVEAYVALKYIGMSRD--EPPMQKALRFIQSQGGIESSRVFTRMWLALVGEYPWRGVPMVPPEIMLLPKRFPFNIYEFSS 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 257 HCRMVYLPMSYLYGRRFVCRTNGTILSlrRELYTIpyhhidwdtarnQCAKEDLYYPHPKIQDVLWSCLNKFGEpLLERW 336
Cdd:TIGR01507 172 WARATVVPLSIVCSRKPVFPLPERARV--PELYET------------DVPKPRRRGAKGGTGWGIFDALDRALH-GYEKL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 337 PLNNLRNHALQTVMQHIhYEDQN--SHYICIGP--VN-----KVLNMlccwveSSNSEAFKSHLSRIKDYLWVAEDGMKM 407
Cdd:TIGR01507 237 SVHPFRRAAEIRALDWL-LERQAgdGSWGGIQPamFNalialKILGM------TQHDAFIKLGWEGIDLYGVELDDSWMF 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 408 QGyNGSQLWDVTLAVQAILATNLVDDYgLMLKKAHNYIKNTQIrkDTSGDPGLWYRHPCKGGWGFSTGDNPWPVSDCTAE 487
Cdd:TIGR01507 310 QA-CVSPVWDTALAVLALREAGLPADH-DALVKAGEWLLDKQI--TVPGDWAVKRPNLEPGGWAFQFDNVYYPDVDDTAV 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 488 ALKaalllSQMPVNLVGEPMPEEHLVDAVNFILSLQNKNGGFASYELTRSYPELEVInpseTFGDI--IIDYQYVECTSA 565
Cdd:TIGR01507 386 VVW-----ALNGLRLPDERRRRDAMTKAFRWIAGMQSSNGGWGAFDVDNTSDLLNHI----PFCDFgaVTDPPTADVTAR 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 566 AIQGLVLFTtLNSSYKRkeivgsINKAVEFIEKTQLPDGSWYGSWGVCFTYATWFGIKGMLASG-KTYESSlcIRKACGF 644
Cdd:TIGR01507 457 VLECLGSFG-YDDAWPV------IERAVEYLKREQEPDGSWFGRWGVNYLYGTGAVLSALKAVGiDTREPY--IQKALAW 527
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 645 LLSKQLCCGGWGESYLSCQNKVYTNlPGNkSHIVNTSWALLALIEAGQASRDpmPLHRGAKSLINSQMEDGDYPQQEILG 724
Cdd:TIGR01507 528 LESHQNPDGGWGEDCRSYEDPAYAG-KGA-STASQTAWALIALIAAGRAESE--AARRGVQYLVETQRPDGGWDEPYYTG 603
|
650 660
....*....|....*....|....*....
gi 1063715067 725 V-FNRNCMISYSAYRNIFPIWALGEYRKL 752
Cdd:TIGR01507 604 TgFPGDFYLGYHMYRHVFPLLALARYKQA 632
|
|
| SQHop_cyclase_C |
pfam13243 |
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ... |
413-751 |
1.38e-42 |
|
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the C-terminal half of the molecule.
Pssm-ID: 433057 [Multi-domain] Cd Length: 319 Bit Score: 157.11 E-value: 1.38e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 413 SQLWDVTLAVQAILATNlVDDYGLMLKKAHNYIKNTQIRkdtsgDPGLWY---RHPCKGGWGFSTgDNPW-PVSDCTAEA 488
Cdd:pfam13243 2 SPVWDTALALHALLEAG-VPADHPALVKAAQWLLDRQVL-----VKGDWAvkrPDLEPGGWAFQF-ANDHyPDVDDTAVV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 489 LKAALLlsqmpVNLVGEPMPEEHLVDAVNFILSLQNKNGGFASYELTRSYpelEVIN--PsetFGDI--IIDYqyvecTS 564
Cdd:pfam13243 75 VLALDR-----VRLPDERRRDDAIARGIEWILGMQSKNGGWGAFDKDNTK---YYLNkiP---FADHgaLLDP-----PT 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 565 AAIQGLVLFTTLNSSYKRKEIVgsINKAVEFIEKTQLPDGSWYGSWGVCFTYATWFGIKGMLASGKTYESSLcIRKACGF 644
Cdd:pfam13243 139 ADVTARVLEMLGQLGYPDDHPV--AARALEYLKKEQEPDGSWFGRWGVNYIYGTWSVLCGLAAVGEDHNRPY-IRKAVDW 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 645 LLSKQLCCGGWGEsylSCQNKVYTNLPG-NKSHIVNTSWALLALIEAGQASRDpmPLHRGAKSLINSQMEDGDYPQQEIL 723
Cdd:pfam13243 216 LKSRQNPDGGWGE---DCESYKDPKLAGrGPSTASQTAWALLALMAAGEVDSP--AVRRGIQYLLETQKPDGTWDEPYFT 290
|
330 340
....*....|....*....|....*....
gi 1063715067 724 GV-FNRNCMISYSAYRNIFPIWALGEYRK 751
Cdd:pfam13243 291 GTgFPRVFYLKYHGYRNYFPLWALARYRN 319
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
388-749 |
1.39e-40 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 151.16 E-value: 1.39e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 388 KSHLSRIKDYLwvAEDGMKMQGYNGSQLWDVTLAVQAIL----ATNLVDDYGLMLKKAHNYIKNtqirkdtsgdpglwYR 463
Cdd:cd00688 2 EKHLKYLLRYP--YGDGHWYQSLCGEQTWSTAWPLLALLlllaATGIRDKADENIEKGIQRLLS--------------YQ 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 464 HPcKGGWGFSTGdNPWPVSDCTAEALKAALLLSQMpvnlvgEPMPEEHLVDAVNFILSLQNKNGGFASYEltrsypelev 543
Cdd:cd00688 66 LS-DGGFSGWGG-NDYPSLWLTAYALKALLLAGDY------IAVDRIDLARALNWLLSLQNEDGGFREDG---------- 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 544 inpsETFGDIIIDYQYVECTSAAIQGLVLFttlnssyKRKEIVGSINKAVEFIEKTQLPDGSWyGSWGVCFTYATWFGIK 623
Cdd:cd00688 128 ----PGNHRIGGDESDVRLTAYALIALALL-------GKLDPDPLIEKALDYLLSCQNYDGGF-GPGGESHGYGTACAAA 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 624 GMLASGKTyeSSLCIRKACGFLLSKQLCCGGWGESYLscqnkvytnLPGNKSHIVNTSWALLALIEAGQAsRDPMPLHRG 703
Cdd:cd00688 196 ALALLGDL--DSPDAKKALRWLLSRQRPDGGWGEGRD---------RTNKLSDSCYTEWAAYALLALGKL-GDLEDAEKL 263
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1063715067 704 AKSLINSQMEDGDYPQQEIlgvfnrncmISYSAYRNIFPIWALGEY 749
Cdd:cd00688 264 VKWLLSQQNEDGGFSSKPG---------KSYDTQHTVFALLALSLY 300
|
|
| SQHop_cyclase_N |
pfam13249 |
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ... |
107-347 |
1.54e-30 |
|
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the N-terminal domain.
Pssm-ID: 433061 [Multi-domain] Cd Length: 290 Bit Score: 121.82 E-value: 1.54e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 107 LQSQDGFWPGDyggplfL-----LPALVIGL-YVTEVLDGTLTAqhqiEIRRYLYNHQNKDGGWGLHVEGNSTMFCTVLS 180
Cdd:pfam13249 11 LQHPDGHWVGE------LeanvtITAEYILLrHFLGPDDPELEA----KIARYLRSQQREDGGWPLFHGGPGDLSTTVEA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 181 YVALRLMGEELDggDGAMESARSWIHHHGGATFIPSWGKFWLSVLGAYEWSG------------NNplppelwllpysLP 248
Cdd:pfam13249 81 YFALKLLGDSPD--APHMVRAREFILARGGAAKANVFTRIWLALFGQYPWRGvpsmppeimllpRW------------FP 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 249 FHPGRMWCHCRMVYLPMSYLYGRRFVCRTNGTIlsLRRELYTIPYHHIDwdtarnqcakedlYYPHPKiQDVLWSCLNKF 328
Cdd:pfam13249 147 FNIYKFSSWARTTIVPLLILSALKPVAPLPPGI--GLDELFVEPPENVR-------------YYPRPH-RLFSWTNLFLG 210
|
250 260
....*....|....*....|..
gi 1063715067 329 GEPLL---ERWPLNNLRNHALQ 347
Cdd:pfam13249 211 LDRVLklyERLPPKPLRRRALR 232
|
|
| squa_tetra_cyc |
TIGR04277 |
squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, ... |
125-751 |
1.70e-14 |
|
squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, occurs a small number of eukaryotes, some of them anaerobic. The pathway can occur under anaerobic conditions, and the product is thought to replace sterols, letting organisms with this compound build membrane suitable for performing phagocytosis.
Pssm-ID: 212000 [Multi-domain] Cd Length: 624 Bit Score: 77.37 E-value: 1.70e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 125 LPALVIGLYVTEVLDGTLTAQHQIEIRRY---LYNHQNKDGGWGLHVEGN---STMFCTVLSYVALRLMGEELDGgDGAM 198
Cdd:TIGR04277 45 LGELFISEYYFELKALGWIHKSAFEASKFteiLLGSQFEDGSWEQVEDANietGQLDATIFNYWYLKAIGIDIHI-DAAL 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 199 ESARSWIHHHGGATFIPSWGKFWLSVLGAYEWSgnNPLPPELWLLPYSLPFHPGRM------WCHCRMVYLpmSYLYGRR 272
Cdd:TIGR04277 124 KKAQEWIKANGGIEAAQTMTKFKLAAFGQYPWE--DLFKIPLFIFKKKGIFKPLYIkditaqWVYPHLTAL--AYLQNQR 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 273 FVCRTNgtiLSLRRELYTipyhhidwDTARNQCAKEDLYYPHPKIQDVLWSCLNkfgEPLLERWPLNNLRNHALQTVMQH 352
Cdd:TIGR04277 200 IIFNVA---VADIRELWI--------NKAKKGIKHQKKERPSFFIDNDLLILMD---EIFKLKQPLGSFGAYTISTLLSL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 353 IHYEDQNShyicigpvnKVLNMlccwvessnseafksHLSRIKDYLwvaEDGMKM---------QGYNGS----QLWDVT 419
Cdd:TIGR04277 266 LAFKDFQG---------KHPHK---------------HKNEIQDAL---EDGLDFvefnyfnfrEAYHGSlddgRWWDTI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 420 LAVQAILATnlvddyGLMLKKAHNYIKNtQIRKDTSGDPGLWYrhpckgGWGFSTGdnpwPVSDCTAEALKAALLLSQMp 499
Cdd:TIGR04277 319 LISWAMLES------GEDKEKIFPIVEN-MLKEGLQPKGGIEY------GYDFEYA----PDADDTGLLLQVLSYYGEA- 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 500 vnlVGEPMPEehlvdAVNFILSLQNKNGGFASYELTR---------SYPELEVINPSETFgdiiiDYQYVECTSAAIQGL 570
Cdd:TIGR04277 381 ---FADAIDE-----GAEFLFSMQNDDGGFPAFDKGKmednllfkfAFKIAGIADSAEIF-----DPSCPDITAHILEGL 447
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 571 VLFTTlNSSYKRkeivgsINKAVEFIEKTQLPDGSWYGSWGVCFTYATWFGIKGmLASGKTYESSLCIRKACGFLLSKQL 650
Cdd:TIGR04277 448 GEFGD-QANHDQ------IQKMIKYFMDTQEKFGSWEARWGINYIMAAGAVLPA-LAKMNYDLNEGWAKNAINWLLNKQN 519
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 651 CCGGWGESYLSCQNKVYTNLPGnKSHIVNTSWALLALIEA-GQASRDPMPLHRGAKSLINS-QMEDGDYPQQEILGVFNR 728
Cdd:TIGR04277 520 ADGGFGECTLSYNDPEKWNGIG-KSTVTQTSWGLLALLAVeDHNDQIKEAADKAAQYLLDQfKRDDGEFKDHSTIGTGHR 598
|
650 660
....*....|....*....|....
gi 1063715067 729 NCM-ISYSAYRNIFPIWALGEYRK 751
Cdd:TIGR04277 599 GLLyLQYPSYAQSFPLIALGRFLD 622
|
|
| Prenyltrans |
pfam00432 |
Prenyltransferase and squalene oxidase repeat; |
149-188 |
1.06e-06 |
|
Prenyltransferase and squalene oxidase repeat;
Pssm-ID: 395346 [Multi-domain] Cd Length: 44 Bit Score: 45.97 E-value: 1.06e-06
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1063715067 149 EIRRYLYNHQNKDGGWGLHVEGNSTMFCTVLSYVALRLMG 188
Cdd:pfam00432 5 KLVDYLLSCQNEDGGFGGRPGGESDTYYTYCALAALALLG 44
|
|
| Prenyltrans |
pfam00432 |
Prenyltransferase and squalene oxidase repeat; |
589-622 |
1.27e-06 |
|
Prenyltransferase and squalene oxidase repeat;
Pssm-ID: 395346 [Multi-domain] Cd Length: 44 Bit Score: 45.58 E-value: 1.27e-06
10 20 30
....*....|....*....|....*....|....*
gi 1063715067 589 INKAVEFIEKTQLPDGSWYGSWGVC-FTYATWFGI 622
Cdd:pfam00432 3 KEKLVDYLLSCQNEDGGFGGRPGGEsDTYYTYCAL 37
|
|
| Prenyltrans |
pfam00432 |
Prenyltransferase and squalene oxidase repeat; |
638-687 |
4.90e-03 |
|
Prenyltransferase and squalene oxidase repeat;
Pssm-ID: 395346 [Multi-domain] Cd Length: 44 Bit Score: 35.56 E-value: 4.90e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1063715067 638 IRKACGFLLSKQLCCGGWGESylscqnkvytnlPGNKSHIVNTSWALLAL 687
Cdd:pfam00432 3 KEKLVDYLLSCQNEDGGFGGR------------PGGESDTYYTYCALAAL 40
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
582-698 |
6.44e-03 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 39.29 E-value: 6.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715067 582 RKEIVGSINKAVEFIEKTQLPDGSwYGSWGVCFTYATW---FGIKGML-ASGKTYESSLCIRKACGFLLSKQLCCGGWGE 657
Cdd:cd02891 44 REKALEYIRKGYQRLLTYQRSDGS-FSAWGNSDSGSTWltaYVVKFLSqARKYIDVDENVLARALGWLVPQQKEDGSFRE 122
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1063715067 658 SYlscQNKVYTNLPGNKSHIVNTSWALLALIEAGQASRDPM 698
Cdd:cd02891 123 LG---PVIHREMKGGVDDSVSLTAYVLIALAEAGKACDASI 160
|
|
| |
