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Conserved domains on  [gi|1063726968|ref|NP_001328129|]
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tonoplast monosaccharide transporter2 [Arabidopsis thaliana]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 516-713 3.03e-69

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17315:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 365  Bit Score: 231.31  E-value: 3.03e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 516 RALVVGVGLQILQQFSGINGVLYYTPQILEQAGVG---ILLSnmgissssasllisALTTFVMLPAIAVAMRLMDLSGRR 592
Cdd:cd17315   179 RALLVGVGLQLLQQLTGINAVMYYAPTIFKSAGGGtasILAS--------------IIVGVVNLLATLVAIRLVDKVGRR 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 593 TLLLTTIPILIASLLVLVISNLVHMNSIVHAVLSTVSVVLYFCFFVMGFGPAPNILCSEIFPTRVRGICIAICALTFWIC 672
Cdd:cd17315   245 PLLLIGFAGMAASLLLLAIAFLLPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIF 324

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1063726968 673 DIIVTYSLPVLLKSIGLAGVFGMYAIVCCISWVFVFIKVPE 713
Cdd:cd17315   325 NFIVGLTFLIMVSTIGLAGVFIFFAAVCLLALVFVFFFVPE 365
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 14-174 2.71e-64

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17315:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 365  Bit Score: 218.21  E-value: 2.71e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  14 GNLLQGWDNATIAGAVLYIKKEFNLESNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWS 93
Cdd:cd17315     5 GGLLFGYDLGVINGALLYIAKDLGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  94 PNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYCMVFGMSLMPSPSWRLMLGVLFIP 173
Cdd:cd17315    85 PNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGWWRLMFALAAVP 164


                  .
gi 1063726968 174 S 174
Cdd:cd17315   165 A 165
 
Name Accession Description Interval E-value
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 516-713 3.03e-69

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 231.31  E-value: 3.03e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 516 RALVVGVGLQILQQFSGINGVLYYTPQILEQAGVG---ILLSnmgissssasllisALTTFVMLPAIAVAMRLMDLSGRR 592
Cdd:cd17315   179 RALLVGVGLQLLQQLTGINAVMYYAPTIFKSAGGGtasILAS--------------IIVGVVNLLATLVAIRLVDKVGRR 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 593 TLLLTTIPILIASLLVLVISNLVHMNSIVHAVLSTVSVVLYFCFFVMGFGPAPNILCSEIFPTRVRGICIAICALTFWIC 672
Cdd:cd17315   245 PLLLIGFAGMAASLLLLAIAFLLPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIF 324

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1063726968 673 DIIVTYSLPVLLKSIGLAGVFGMYAIVCCISWVFVFIKVPE 713
Cdd:cd17315   325 NFIVGLTFLIMVSTIGLAGVFIFFAAVCLLALVFVFFFVPE 365
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 14-174 2.71e-64

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 218.21  E-value: 2.71e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  14 GNLLQGWDNATIAGAVLYIKKEFNLESNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWS 93
Cdd:cd17315     5 GGLLFGYDLGVINGALLYIAKDLGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  94 PNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYCMVFGMSLMPSPSWRLMLGVLFIP 173
Cdd:cd17315    85 PNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGWWRLMFALAAVP 164


                  .
gi 1063726968 174 S 174
Cdd:cd17315   165 A 165
Sugar_tr pfam00083
Sugar (and other) transporter;
14-219 1.05e-42

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 160.90  E-value: 1.05e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  14 GNLLQGWDNATIAGAVLYIKKEFN---------LESNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYF 84
Cdd:pfam00083   8 GGFLFGYDTGVIGAFLTLIDFFKNfglsksvssLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFV 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  85 VGSLVMLWSP---NVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYCMVFGMSL-MPS 160
Cdd:pfam00083  88 IGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKtSNS 167

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063726968 161 PSWRLMLGVLFIPSlVFFFLTVFFLPESPRWLVSKGRMLEAKRVLQRLRGREDVSGEMA 219
Cdd:pfam00083 168 DGWRIPLGLQLVPA-LLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVPDVDRELD 225
Sugar_tr pfam00083
Sugar (and other) transporter;
512-726 7.16e-38

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 147.03  E-value: 7.16e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 512 PGVKRALVVGVGLQILQQFSGINGVLYYTPQILEQAGVGillsnmgisSSSASLLISALTTFVmlpAIAVAMRLMDLSGR 591
Cdd:pfam00083 249 KTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLS---------DSFLVTIIVGVVNFV---FTFIAIFLVDRFGR 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 592 RTLLLTTIPILIASLLVLVISNLVHMNSI-VHAVLSTVSVVLYFCFFVMGFGPAPNILCSEIFPTRVRGICIAICALTFW 670
Cdd:pfam00083 317 RPLLLLGAAGMAICFVILGIVALLGVSKSdWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANW 396

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1063726968 671 ICDIIVTYSLPVLLKSIGLAGVFGMYAIVCCISWVFVFIKVPETKGMPLEVITEFF 726
Cdd:pfam00083 397 LANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEIDELF 452
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 14-214 2.50e-36

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 143.25  E-value: 2.50e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  14 GNLLQGWDNATIAGAVLYIKKEF-----NLESNPSVE-GLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGS 87
Cdd:TIGR00879  36 GGLMFGYDTGVIGGALALPAFEFkftsaNSDSYSSSLwGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGA 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  88 LVMLWSPN---VYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYCMVFGMSLMPSPS-W 163
Cdd:TIGR00879 116 ILMGLAAFalsVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFGSGKVSLNNTLgW 195

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063726968 164 RLMLGVLFIPSlVFFFLTVFFLPESPRWLVSKGRMLEAKRVLQRLRGREDV 214
Cdd:TIGR00879 196 RIPLGLQLIPA-GLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRGTSGE 245
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 484-722 1.56e-32

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 132.08  E-value: 1.56e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 484 LLKEHTIGPAMVHPSETTKGSiWHDLHD--PGVKRALVVGVGLQILQQFSGINGVLYYTPQILEQAGVGillSNMGISSS 561
Cdd:TIGR00879 250 LDELELIDIKRSIEKRSVQPS-WGSLFSstRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVS---TDHAFLVS 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 562 SASLLISALTTFVmlpaiavAMRLMDLSGRRTLLLttIPILIASLLVLVISNL----VHMNSIVHAVLSTVSVVLYFCFF 637
Cdd:TIGR00879 326 IIVGAVNFAFTFV-------AIFLVDRFGRRPLLL--IGAAGMAICLFVLGILgasfVTGSSKSSGNVAIVFILLFIAFF 396

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 638 VMGFGPAPNILCSEIFPTRVRGICIAICALTFWICDIIVTYSLPVLLKSIGLAGVFGMYAIVCCISWVFVFIKVPETKGM 717
Cdd:TIGR00879 397 AMGWGPVPWVIVSEIFPLSLRPKGISIAVAANWLANFIVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFVYFFLPETKGR 476


                  ....*
gi 1063726968 718 PLEVI 722
Cdd:TIGR00879 477 TLEEI 481
xylE PRK10077
D-xylose transporter XylE; Provisional
 14-232 4.01e-27

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 115.56  E-value: 4.01e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  14 GNLLQGWDNATIAGAVLYIKKEF------NLESNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGS 87
Cdd:PRK10077   20 GGLLFGYDTAVISGTVESLNTVFvapqnlSESAANSLLGFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAAVLFFISA 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  88 LVMLW---------SPN---VYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYCMVFGM 155
Cdd:PRK10077  100 LGSAWpefgftsigPDNtgyVPEFVIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQLVVYFVNYFI 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 156 SLMPSPS------WRLMLGVLFIPSlVFFFLTVFFLPESPRWLVSKGRMLEAKRVLQRLRGREDVSGEMALLVEGLGIGG 229
Cdd:PRK10077  180 ARSGDASwlntdgWRYMFASEAIPA-LLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGNTLATQALQEIKHSLDHGR 258


                  ...
gi 1063726968 230 ETT 232
Cdd:PRK10077  259 KTG 261
xylE PRK10077
D-xylose transporter XylE; Provisional
 518-720 1.10e-23

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 105.16  E-value: 1.10e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 518 LVVGVGLQILQQFSGINGVLYYTPQILEQAGVGILLSNMgissssasllisalTTFVM----LPAIAVAMRLMDLSGRRT 593
Cdd:PRK10077  272 IVIGVMLSVFQQFVGINVVLYYAPEIFKTLGASTDIALL--------------QTIIVgvinLTFTVLAIMTVDKFGRKP 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 594 LLLttIPILIASLLVLVISNLVHMNSIvhAVLSTVSVVLYFCFFVMGFGPAPNILCSEIFPTRVRGICIAICALTFWICD 673
Cdd:PRK10077  338 LQI--IGALGMAIGMFSLGTAFYTQAP--GIVALLSMLFYVAAFAMSWGPVCWVLLSEIFPNAIRGKALAIAVAAQWIAN 413

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1063726968 674 IIVTYSLPVLLKSIGLAGVF------GMYAIVCCISWVFVFIKVPETKGMPLE 720
Cdd:PRK10077  414 YFVSWTFPMMDKNSWLVAHFhngfsyWIYGCMGVLAALFMWKFVPETKGKTLE 466
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 14-205 1.18e-22

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 99.11  E-value: 1.18e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  14 GNLLQGWDNATIAGAVLYIKKEFNLesNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWS 93
Cdd:COG0477    22 GTFLEGLDFTIVNVALPSIAADLGA--SSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  94 PNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYcmVFGMSLMPSPSWRLMLGVLfIP 173
Cdd:COG0477   100 PSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGP--LLGGLLVAALGWRWIFLIN-AP 176

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1063726968 174 SLVFFFLTVFFLPESPRWLVSKGRMLEAKRVL 205
Cdd:COG0477   177 LGLLALVLRLRLPESRGLLLALLALALAALLL 208
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
572-715 2.05e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 53.72  E-value: 2.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 572 TFVMLPAIAVAMRLMDLSGRRTLLLTTIPILIASLLVLVISNLVHMnsivhavlsTVSVVLYFCFFVMGFGPAPNI--LC 649
Cdd:COG2271   226 FLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSP---------ALAIALLFLAGFGLGGAFGLLwaLA 296

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063726968 650 SEIFPTRVRGICIAICALTFWICDIIVTYSLPVLLKSIGLAGVFGMYAIVCCISWVFVFIKVPETK 715
Cdd:COG2271   297 AELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
 
Name Accession Description Interval E-value
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 516-713 3.03e-69

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 231.31  E-value: 3.03e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 516 RALVVGVGLQILQQFSGINGVLYYTPQILEQAGVG---ILLSnmgissssasllisALTTFVMLPAIAVAMRLMDLSGRR 592
Cdd:cd17315   179 RALLVGVGLQLLQQLTGINAVMYYAPTIFKSAGGGtasILAS--------------IIVGVVNLLATLVAIRLVDKVGRR 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 593 TLLLTTIPILIASLLVLVISNLVHMNSIVHAVLSTVSVVLYFCFFVMGFGPAPNILCSEIFPTRVRGICIAICALTFWIC 672
Cdd:cd17315   245 PLLLIGFAGMAASLLLLAIAFLLPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIF 324

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1063726968 673 DIIVTYSLPVLLKSIGLAGVFGMYAIVCCISWVFVFIKVPE 713
Cdd:cd17315   325 NFIVGLTFLIMVSTIGLAGVFIFFAAVCLLALVFVFFFVPE 365
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 14-174 2.71e-64

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 218.21  E-value: 2.71e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  14 GNLLQGWDNATIAGAVLYIKKEFNLESNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWS 93
Cdd:cd17315     5 GGLLFGYDLGVINGALLYIAKDLGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  94 PNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYCMVFGMSLMPSPSWRLMLGVLFIP 173
Cdd:cd17315    85 PNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGWWRLMFALAAVP 164


                  .
gi 1063726968 174 S 174
Cdd:cd17315   165 A 165
Sugar_tr pfam00083
Sugar (and other) transporter;
14-219 1.05e-42

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 160.90  E-value: 1.05e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  14 GNLLQGWDNATIAGAVLYIKKEFN---------LESNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYF 84
Cdd:pfam00083   8 GGFLFGYDTGVIGAFLTLIDFFKNfglsksvssLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFV 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  85 VGSLVMLWSP---NVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYCMVFGMSL-MPS 160
Cdd:pfam00083  88 IGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKtSNS 167

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063726968 161 PSWRLMLGVLFIPSlVFFFLTVFFLPESPRWLVSKGRMLEAKRVLQRLRGREDVSGEMA 219
Cdd:pfam00083 168 DGWRIPLGLQLVPA-LLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVPDVDRELD 225
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 499-720 4.00e-42

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 158.89  E-value: 4.00e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 499 ETTKGSIWHDLHDPGVKRALVVGVGLQILQQFSGINGVLYYTPQILEQAGVGILlSNMGISSSSAsllisalttfVMLPA 578
Cdd:cd17358   222 KEAKESSFSDLFQRKYLKPLVIGLGLMLFQQLSGINAVIFYASSIFDEAGSGLD-PNTATIIIGV----------VQVVG 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 579 IAVAMRLMDLSGRRTLLLTTIPILIASLLVLVISNLVHMNSIVHA---VLSTVSVVLYFCFFVMGFGPAPNILCSEIFPT 655
Cdd:cd17358   291 TLVATLLVDRLGRRPLLLVSAIGMGIGLLALGLYFYLQEHGALLSsvsWLPLVGLVIYIISFSIGLGPLPWVIMSEIFPA 370

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063726968 656 RVRGICIAICALTFWICDIIVTYSLPVLLKSIGLAGVFGMYAIVCCISWVFVFIKVPETKGMPLE 720
Cdd:cd17358   371 KIKGLAGSLVTLVNWLFAFIVTKTFPFLTLAWGASGTFWIFAGICGLALVFVLLFVPETKGKSLE 435
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 14-197 1.15e-41

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 156.19  E-value: 1.15e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  14 GNLLQGWDNATIAGAVLYIKKEFNLesNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWS 93
Cdd:cd17359     9 GGLLFGYDTGVINGALPFLQTDFNL--TPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFS 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  94 PNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYCM------VFGMSLMPSPSWRLML 167
Cdd:cd17359    87 PNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVnylianAGGADWLGAEGWRWML 166

                         170       180       190
                  ....*....|....*....|....*....|
gi 1063726968 168 GVLFIPSlVFFFLTVFFLPESPRWLVSKGR 197
Cdd:cd17359   167 GLEAIPA-ILFLLGMLFIPESPRWLVSKGK 195
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 515-713 6.38e-39

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 148.48  E-value: 6.38e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 515 KRALVVGVGLQILQQFSGINGVLYYTPQILEQAGVGI---LLSNMGissssasllisalTTFVMLPAIAVAMRLMDLSGR 591
Cdd:cd17359   195 KPILIIGIGLAIFQQFVGINVIFYYGPEIFQNAGFSEnaaLLQTIG-------------IGVVNVIFTIIAILLVDKVGR 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 592 RTLLLTTIPILIASLLVLVISNLVHMNSIVHAVLSTVSVVLYFCFFVMGFGPAPNILCSEIFPTRVRGICIAICALTFWI 671
Cdd:cd17359   262 KPLLLIGSIGMAISLLLIGTAFYFAPGSQASGIVALVLILLFVAFFAMSWGPVTWVLLSEIFPNRIRGLAMGIAVFFLWI 341

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1063726968 672 CDIIVTYSLPVLLKSIGLAGVFGMYAIVCCISWVFVFIKVPE 713
Cdd:cd17359   342 ANFLVSLTFPILLAAFGLAFTFLIFAVICVLAFLFVWKFVPE 383
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 14-191 4.75e-38

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 145.49  E-value: 4.75e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  14 GNLLQGWDNATIAGAVLYIKKEFNLESNPSVE-GLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLW 92
Cdd:cd17360     5 GGFLFGYDTGVISGALLYIKDDLGEVVLSTGWqELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  93 SPNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYCMVFGMSLMPSpSWRLMLGVLFI 172
Cdd:cd17360    85 APNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLPG-GWRWMLGLAAV 163

                         170
                  ....*....|....*....
gi 1063726968 173 PSlVFFFLTVFFLPESPRW 191
Cdd:cd17360   164 PA-VLQFIGLLFLPESPRW 181
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 512-713 6.92e-38

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 145.11  E-value: 6.92e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 512 PGVKRALVVGVGLQILQQFSGINGVLYYTPQILEQAGV-----GILLSnmgissssasllisALTTFVMLPAIAVAMRLM 586
Cdd:cd17360   182 PSTRRALIVGCGLQAFQQFSGINTVMYYSATILQMAGFkdnqnAIWLS--------------LIVAGTNFIFTIVGMYLI 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 587 DLSGRRTLLLTTIPILIASLLVLVIsnlvhmnsivhaVLSTVSVVLYFCFFVMGFGPAPNILCSEIFPTRVRGICIAICA 666
Cdd:cd17360   248 DKFGRRKLLLISLFGVIVALVVLAV------------WLALVGLILYLAFFAPGMGPVPWTVNSEIYPLWARGTGGGCAA 315

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1063726968 667 LTFWICDIIVTYSLPVLLKSIGLAGVFGMYAIVCCISWVFVFIKVPE 713
Cdd:cd17360   316 AVNWVFNLLVSQTFLTLTQAIGPYGTFLLFAGLAVLGLIFIYFCVPE 362
Sugar_tr pfam00083
Sugar (and other) transporter;
512-726 7.16e-38

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 147.03  E-value: 7.16e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 512 PGVKRALVVGVGLQILQQFSGINGVLYYTPQILEQAGVGillsnmgisSSSASLLISALTTFVmlpAIAVAMRLMDLSGR 591
Cdd:pfam00083 249 KTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLS---------DSFLVTIIVGVVNFV---FTFIAIFLVDRFGR 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 592 RTLLLTTIPILIASLLVLVISNLVHMNSI-VHAVLSTVSVVLYFCFFVMGFGPAPNILCSEIFPTRVRGICIAICALTFW 670
Cdd:pfam00083 317 RPLLLLGAAGMAICFVILGIVALLGVSKSdWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANW 396

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1063726968 671 ICDIIVTYSLPVLLKSIGLAGVFGMYAIVCCISWVFVFIKVPETKGMPLEVITEFF 726
Cdd:pfam00083 397 LANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEIDELF 452
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 512-722 6.37e-37

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 142.88  E-value: 6.37e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 512 PGVKRALVVGVGLQILQQFSGINGVLYYTPQILEQAGVgillsnmgiSSSSASLLISALTTFVMLPAIAVAMRLMDLSGR 591
Cdd:cd17362   187 GNYRKPLIIGLGLVLFQQITGQPSVLYYAATIFKSAGF---------SAASDATLVSVGLGVFKLLMTIVAVLLVDKLGR 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 592 RTLLLTTIPILIASLLVLVISNL-VHMNSIVHAVLSTVSVVLYFCFFVMGFGPAPNILCSEIFPTRVRGICIAICALTFW 670
Cdd:cd17362   258 RPLLLGGVSGMVVSLFLLAAYNLfVQMGPAGLAWLSLVALLLYVGAYQISFGPISWLMVSEIFPLRVRGRAIALAVLVNF 337

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1063726968 671 ICDIIVTYSLPVLLKSIGLAGVFGMYAIVCCISWVFVFIKVPETKGMPLEVI 722
Cdd:cd17362   338 GSNALVSLAFLPLQELIGLPGTFLGFGVIGVLALLFIYFTVPETKGLSLEEI 389
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 14-214 2.50e-36

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 143.25  E-value: 2.50e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  14 GNLLQGWDNATIAGAVLYIKKEF-----NLESNPSVE-GLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGS 87
Cdd:TIGR00879  36 GGLMFGYDTGVIGGALALPAFEFkftsaNSDSYSSSLwGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGA 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  88 LVMLWSPN---VYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYCMVFGMSLMPSPS-W 163
Cdd:TIGR00879 116 ILMGLAAFalsVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFGSGKVSLNNTLgW 195

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063726968 164 RLMLGVLFIPSlVFFFLTVFFLPESPRWLVSKGRMLEAKRVLQRLRGREDV 214
Cdd:TIGR00879 196 RIPLGLQLIPA-GLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRGTSGE 245
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 32-219 3.13e-33

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 133.08  E-value: 3.13e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  32 IKKEFNLESNPSVE--GLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFG 109
Cdd:cd17358    28 LMSDNSLSLPLTVAqfSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFG 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 110 VGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYCM--VFGMSLMP----SPSWRLMLGVLFIpslvfffltvf 183
Cdd:cd17358   108 GGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLgsFLPWRTLAligaIPPVVFLILLFFI----------- 176

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1063726968 184 flPESPRWLVSKGRMLEAKRVLQRLRGRE-DVSGEMA 219
Cdd:cd17358   177 --PESPRWLAKKGREEEAEKSLQFLRGKDaDISKEAA 211
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 484-722 1.56e-32

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 132.08  E-value: 1.56e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 484 LLKEHTIGPAMVHPSETTKGSiWHDLHD--PGVKRALVVGVGLQILQQFSGINGVLYYTPQILEQAGVGillSNMGISSS 561
Cdd:TIGR00879 250 LDELELIDIKRSIEKRSVQPS-WGSLFSstRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVS---TDHAFLVS 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 562 SASLLISALTTFVmlpaiavAMRLMDLSGRRTLLLttIPILIASLLVLVISNL----VHMNSIVHAVLSTVSVVLYFCFF 637
Cdd:TIGR00879 326 IIVGAVNFAFTFV-------AIFLVDRFGRRPLLL--IGAAGMAICLFVLGILgasfVTGSSKSSGNVAIVFILLFIAFF 396

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 638 VMGFGPAPNILCSEIFPTRVRGICIAICALTFWICDIIVTYSLPVLLKSIGLAGVFGMYAIVCCISWVFVFIKVPETKGM 717
Cdd:TIGR00879 397 AMGWGPVPWVIVSEIFPLSLRPKGISIAVAANWLANFIVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFVYFFLPETKGR 476


                  ....*
gi 1063726968 718 PLEVI 722
Cdd:TIGR00879 477 TLEEI 481
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
 512-722 2.97e-32

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 129.44  E-value: 2.97e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 512 PGVKRALVVGVGLQILQQFSGINGVLYYTPQILEQAGV----GILLSNMGISSSSasllisalTTFvmlpaIAVAMRLMD 587
Cdd:cd17437   182 PAVRRMLIAALGIHFFQQASGIDAVVLYSPRIFKKAGIkskdKLLLATVAVGVTK--------TLF-----ILVATFLLD 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 588 LSGRRTLLLTTIPILIASLLVLVIS----NLVHMNSIVHAVLSTVSVVLYFCFFVMGFGPAPNILCSEIFPTRVRGICIA 663
Cdd:cd17437   249 KVGRRPLLLTSTGGMTLSLTALATSltfiDRNGGGLTWALVLAITAVCSFVAFFSIGAGPITWVYSSEIFPLRLRAQGAS 328

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063726968 664 ICALTFWICDIIVTYSLPVLLKSIGLAGVFGMYAIVCCISWVFVFIKVPETKGMPLEVI 722
Cdd:cd17437   329 LGVVVNRLMSGTVSMTFLSMSKAITTGGTFFLFAGVAAAAWVFFYFFLPETKGKSLEEI 387
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
 15-199 1.75e-31

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 127.13  E-value: 1.75e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  15 NLLQGWDNATIAGAVLYIKKEFNLeSNPSVEGLIVAMSLIgaTLITTCSGG-VADWLGRRPMLILSSILYFVGSLVMLWS 93
Cdd:cd17437     6 SILLGYDIGVMSGAVIFIKEDLKI-SDVQEEVLIGSLNII--SLVGSLAAGrTSDWIGRRYTIALAALIFFVGALLMGVA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  94 PNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYCMVFGMSLMPSP-SWRLMLGVLFI 172
Cdd:cd17437    83 PNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYVSNYAFSGLPLHvGWRLMLGVGAV 162

                         170       180
                  ....*....|....*....|....*..
gi 1063726968 173 PSlVFFFLTVFFLPESPRWLVSKGRML 199
Cdd:cd17437   163 PS-LFLAIGVLAMPESPRWTPAVRRML 188
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 14-201 4.73e-30

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 122.85  E-value: 4.73e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  14 GNLLQGWDNATIAGAVLYIK-------KEFNLESNPSveGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVG 86
Cdd:cd17362     5 GGLLFGYDIGATSGALLSITspalsgtDWYNLSSLQS--GLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  87 SLVMLWSPNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYCMVFGMSLMPSpSWRLM 166
Cdd:cd17362    83 SLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVG-GWRYM 161

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1063726968 167 LGvLFIPSLVFFFLTVFFLPESPRWlvsKGRMLEA 201
Cdd:cd17362   162 YG-LAAPPALLLGIGMWFLPPSPRW---QGNYRKP 192
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 14-192 1.24e-29

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 121.97  E-value: 1.24e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  14 GNLLQGWDNATIAGAV--LYIKKEFNLESN-----PSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVG 86
Cdd:cd17356     9 GGFLFGYDTGSISGILnmKSFQKYFADNTGtyypsSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  87 SLVMLWS-PNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYCMVFGMS-LMPSPSWR 164
Cdd:cd17356    89 AIIQVAAiGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHkLDGSAQWR 168

                         170       180
                  ....*....|....*....|....*...
gi 1063726968 165 LMLGVLFIPSlVFFFLTVFFLPESPRWL 192
Cdd:cd17356   169 IPLGLQIVWG-LLLLIGMFFLPESPRWL 195
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 493-716 2.19e-28

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 118.90  E-value: 2.19e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 493 AMVHPSEttkGSIWHDLHDPGVKRALVVGVGLQILQQFSGINGVLYYTPQILEQAGVGILLSnmgissssasLLISALTT 572
Cdd:cd17357   237 QMGDQKQ---VSLMQLLRDPSLRLPLLLVLVVSASQQFSGINAIFFYSTFIFENAGFSPQLA----------EWANLGIG 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 573 FVMLPAIAVAMRLMDLSGRRTLLLTTIPILIASLLVLVISNLVHMNSIVHAVLSTVSVVLYFCFFVMGFGPAPNILCSEI 652
Cdd:cd17357   304 IVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFLFLSEQNSWMSYGCIVAIFLFIFFFAIGLGPIPWFIGAEL 383

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063726968 653 FPTRVRGICIAICALTFWICDIIVTYSLPvLLKSIGLAGVFGMYAIVCCISWVFVFIKVPETKG 716
Cdd:cd17357   384 FPQAPRSAAQSLGSSVNWTSNFIVGMAFP-PLQSIGGGFVFIIFAIPCALFLLYLYRYLPETKG 446
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 508-720 6.60e-28

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 116.90  E-value: 6.60e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 508 DLHDPGVKRALVVGVGLQILQQFSGINGVLYYTPQILEQAgvgillsNMGISSSSASLLISALTTFVmlpaiAVAMRLMD 587
Cdd:cd17433   228 LLKQPGIYKPLIIGVSLMAFQQLTGINAVMFYAETIFEEA-------KFKDSSVASVIVAAIQVLFT-----AVAALIMD 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 588 LSGRRTLLlttipilIASLLVLVISnlvhmnSIVHAVLSTVSVVLYFCFFVMGFGPAPNILCSEIFPTRVRGICIAICAL 667
Cdd:cd17433   296 RAGRKVLL-------VLSGVVMVFS------TAAFGWLAVGSMGFFIAGFAVGWGPIPWLVMSEIFPLHVRGVASGICVL 362

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1063726968 668 TFWICDIIVTYSLPVLLKSIGLAGVFGMYAIVCCISWVFVFIKVPETKGMPLE 720
Cdd:cd17433   363 TNWLMAFLVTKEFSSLMEVLSSYGTFWLFSAFCAFSVLFTLFCVPETKGKTLE 415
xylE PRK10077
D-xylose transporter XylE; Provisional
 14-232 4.01e-27

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 115.56  E-value: 4.01e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  14 GNLLQGWDNATIAGAVLYIKKEF------NLESNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGS 87
Cdd:PRK10077   20 GGLLFGYDTAVISGTVESLNTVFvapqnlSESAANSLLGFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAAVLFFISA 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  88 LVMLW---------SPN---VYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYCMVFGM 155
Cdd:PRK10077  100 LGSAWpefgftsigPDNtgyVPEFVIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQLVVYFVNYFI 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 156 SLMPSPS------WRLMLGVLFIPSlVFFFLTVFFLPESPRWLVSKGRMLEAKRVLQRLRGREDVSGEMALLVEGLGIGG 229
Cdd:PRK10077  180 ARSGDASwlntdgWRYMFASEAIPA-LLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGNTLATQALQEIKHSLDHGR 258


                  ...
gi 1063726968 230 ETT 232
Cdd:PRK10077  259 KTG 261
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 518-726 8.97e-27

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 113.50  E-value: 8.97e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 518 LVVGVGLQILQQFSGINGVLYYTPQILEQAGVG---ILLSNMgissssasllisaLTTFVMLPAIAVAMRLMDLSGRRTL 594
Cdd:cd17356   198 TILGIMLQLFQQLTGINYFFYYGTTIFQSTGLTgssPLLTSI-------------ILYIVNFVSTIPGLFFVDKFGRRTC 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 595 LL------TTIPILIASLLVLVISNLVHMNSIVHAVLSTVSVVLYF--CFFVMGFGPAPNILCSEIFPTRVRGICIAICA 666
Cdd:cd17356   265 LLigaagmSICLFIYAAVGVRYLIPNPQSGTSNKSAGNGMIVFICLfiFSFATTWGPIAWVYVAEVFPLRVRSKGMALAT 344

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 667 LTFWICDIIVTYSLPVLLKSIGlAGVFGMYAIVCCISWVFVFIKVPETKGMPLEVITEFF 726
Cdd:cd17356   345 AFNWLWNFLISFFTPFIIGSIG-FKYYYIFAGCNLLAFIVVFFFVPETKGLTLEEIDELF 403
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 46-213 2.77e-25

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 109.66  E-value: 2.77e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  46 GLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWS---PNVYVLLLGRLLDGFGVGLVVTLVPIYIS 122
Cdd:cd17357    52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSksaKSPELLIFGRFLVGIACGLSTGFVPMYLQ 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 123 ETAPPEIRGLLNTLPQFTGSGGMFLSycMVFGMSLMPSP--SWRLMLGVLFIPSlVFFFLTVFFLPESPRWLV-SKGRML 199
Cdd:cd17357   132 EISPSELRGALGSLTQIGVTLGILLG--QVFGLPSVLGTetLWPYLLFFPGIPA-LLQLAALPFFPESPKFLLiSKGDEE 208

                         170
                  ....*....|....
gi 1063726968 200 EAKRVLQRLRGRED 213
Cdd:cd17357   209 EAEKSLKFLRGIED 222
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 47-223 4.79e-24

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 105.88  E-value: 4.79e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  47 LIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWS---PNVYVLLLGRLLDGFGVGLVVTLVPIYISE 123
Cdd:cd17431    54 LSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLYNNLLAFAGAALMGLSklaKSYEMLILGRFIIGLYCGLTTGLVPMYIGE 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 124 TAPPEIRGLLNTLPQFTGSGGMFLSycMVFGM-SLMPSPS-WRLMLGVLFIPSlVFFFLTVFFLPESPRWLVSK-GRMLE 200
Cdd:cd17431   134 ISPTALRGALGTLHQLGIVVGILIS--QIFGLeFILGTEElWPLLLGFTIVPA-ILQLALLPFCPESPRYLLINrNEEEE 210

                         170       180
                  ....*....|....*....|...
gi 1063726968 201 AKRVLQRLRGREDVSGEMALLVE 223
Cdd:cd17431   211 AKSVLKKLRGTTDVSEDIQEMKE 233
xylE PRK10077
D-xylose transporter XylE; Provisional
 518-720 1.10e-23

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 105.16  E-value: 1.10e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 518 LVVGVGLQILQQFSGINGVLYYTPQILEQAGVGILLSNMgissssasllisalTTFVM----LPAIAVAMRLMDLSGRRT 593
Cdd:PRK10077  272 IVIGVMLSVFQQFVGINVVLYYAPEIFKTLGASTDIALL--------------QTIIVgvinLTFTVLAIMTVDKFGRKP 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 594 LLLttIPILIASLLVLVISNLVHMNSIvhAVLSTVSVVLYFCFFVMGFGPAPNILCSEIFPTRVRGICIAICALTFWICD 673
Cdd:PRK10077  338 LQI--IGALGMAIGMFSLGTAFYTQAP--GIVALLSMLFYVAAFAMSWGPVCWVLLSEIFPNAIRGKALAIAVAAQWIAN 413

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1063726968 674 IIVTYSLPVLLKSIGLAGVF------GMYAIVCCISWVFVFIKVPETKGMPLE 720
Cdd:PRK10077  414 YFVSWTFPMMDKNSWLVAHFhngfsyWIYGCMGVLAALFMWKFVPETKGKTLE 466
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 14-205 1.18e-22

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 99.11  E-value: 1.18e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  14 GNLLQGWDNATIAGAVLYIKKEFNLesNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWS 93
Cdd:COG0477    22 GTFLEGLDFTIVNVALPSIAADLGA--SSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  94 PNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYcmVFGMSLMPSPSWRLMLGVLfIP 173
Cdd:COG0477   100 PSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGP--LLGGLLVAALGWRWIFLIN-AP 176

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1063726968 174 SLVFFFLTVFFLPESPRWLVSKGRMLEAKRVL 205
Cdd:COG0477   177 LGLLALVLRLRLPESRGLLLALLALALAALLL 208
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 512-716 1.13e-19

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 92.40  E-value: 1.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 512 PGVKRALVVGVGLQILQQFSGINGVLYYTPQILEQAGVG-ILLSNMGISSssasllisalttfVMLPAIAVAMRLMDLSG 590
Cdd:cd17431   253 SSYRQPIIIAIVLQLSQQLSGINAVFYYSTSIFEKAGVQqPVYATIGAGV-------------VNTIFTVVSLFLVERAG 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 591 RRTLLLTTIPILIASLLVLVISNLVHMNSIVHAVLSTVSVVLYFCFFVMGFGPAPNILCSEIFPTRVRGICIAICALTFW 670
Cdd:cd17431   320 RRTLHLIGLGGMAICAILMTIALLLLEGYPWMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNW 399

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1063726968 671 ICDIIVTYSLPVLLKSIGlAGVFGMYAIVCCISWVFVFIKVPETKG 716
Cdd:cd17431   400 TSNFIVGMCFQYIANLCG-PYVFIIFTVFLLTFFIFTYFKVPETKG 444
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
 52-174 1.67e-19

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 91.16  E-value: 1.67e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  52 SLIGATLITT-CSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIR 130
Cdd:cd17361    59 SLYLAGLVASlLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLR 138

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1063726968 131 GLLNTLPQFTGSGGMFLSYCMVFGMSLMPSPSWRLMLGVLFIPS 174
Cdd:cd17361   139 GALNIGFQLAITIGILIANLINYGTSKIKPNGWRLSLGLAAVPA 182
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 506-720 1.98e-19

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 91.43  E-value: 1.98e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 506 WHDLHDPGVKRALVVGVGLQILQQFSGINGVLYYTPQILEQAGVGIllsnmgissssASLLISALTTFVMLPAIAVAMRL 585
Cdd:cd17434   226 WAELKTPSYYKPILIAVVMRFLQQLTGITPILVYLEPIFHLTAVIL-----------EPKYDAALVGAVRLLSVAIAASL 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 586 MDLSGRRTLLLTTIPILIASLLVLVISNLVhmnsivhavlstvSVVLYFCFFVMGFGPAPNILCSEIFPTRVRGICIAIC 665
Cdd:cd17434   295 MDKAGRKILLFTSAFLMFAANLSMGLIPLI-------------AAMLFIMGYAMGWGPITWLLMSEILPLKARGVASGLC 361

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1063726968 666 ALTFWICDIIVTYSLPVLLKSIGLAGVFGMYAIVCCISWVFVFIKVPETKGMPLE 720
Cdd:cd17434   362 VVVSWITAFVLTQLFLPVVVTFGLQVPFLFFAAVCAVSIIFTACCVPETKGRTLE 416
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
14-210 2.78e-19

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 90.03  E-value: 2.78e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  14 GNLLQGWDNATIAGAVLYIKKEFNLesNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWS 93
Cdd:COG2814    18 GAFLSGLGIGIVLPALPLIAADLGA--SPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  94 PNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSycMVFGMSLMPSPSWRLMLGVLFIP 173
Cdd:COG2814    96 PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALG--PLLGGLLADLFGWRWVFLVNAVL 173

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1063726968 174 SLVFFFLTVFFLPESPRwlVSKGRMLEAKRVLQRLRG 210
Cdd:COG2814   174 ALLALLLLLRLLPESRP--AARARLRGSLRELLRRPR 208
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 14-174 1.46e-18

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 88.04  E-value: 1.46e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  14 GNLLQGWDNATIAGAVLYIKKEFNLESNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWS 93
Cdd:cd17316     7 GWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  94 PNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYCMVFGMSLMPSP--SWRLMLGVLF 171
Cdd:cd17316    87 PTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGdwGWRILFLIGA 166


                  ...
gi 1063726968 172 IPS 174
Cdd:cd17316   167 LPA 169
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 514-722 5.76e-18

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 86.39  E-value: 5.76e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 514 VKRALVVGVGLQILQQFSGINGVLYYTPQILE----QAGVGILLSNMGISSssasllisalttfVMLPAIAVAMRLMDLS 589
Cdd:cd17436   189 MRRRTLVGLGLVLFQQFTGQPNVLCYASTIFRsvgfQSNSSAVLASVGLGV-------------VKVIATLLAMLFADRA 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 590 GRRTLLlttipilIASLLVLVISnlVHMNSIVHAVLSTVSVVLYFCFfvmGFGPAPNILCSEIFPTRVRGICIAICALTF 669
Cdd:cd17436   256 GRRSLL-------IAGCSVMAVS--VSGIGLWITLLCLMAFVSAFSI---GFGPMTWLVLSEIYPADIRGRAFSFCNSFN 323

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1063726968 670 WICDIIVTYSLPVLLKSIGLAGVFGMYAIVCCISWVFVFIKVPETKGMPLEVI 722
Cdd:cd17436   324 WAANLLITLSFLDLIDVIGLSWTFLLYGVVGVAGVVFIYLFVPETKGQSLEEI 376
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 47-218 7.30e-18

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 86.90  E-value: 7.30e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  47 LIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVY---VLLLGRLLDGFGVGLVVTLVPIYISE 123
Cdd:cd17432    54 LTVSIFPLGGLFGSLLVGPLVIRLGRKGTLLLNNIFAIVAAILMGLSKIAKsfeMIIVGRFLVGINAGISLNVVPMYLGE 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 124 TAPPEIRGLLNTLPQFTGSGGMFLSycMVFGMS--LMPSPSWRLMLGVLFIPSlVFFFLTVFFLPESPRW-LVSKGRMLE 200
Cdd:cd17432   134 SAPKNLRGAVGLVPAIFITLGILLG--QVLGLRelLGNEEGWPLLLALTGVPA-LLQLLTLPFFPESPRYlLIEKGDEEA 210

                         170
                  ....*....|....*...
gi 1063726968 201 AKRVLQRLRGREDVSGEM 218
Cdd:cd17432   211 ARKALQRLRGKEDVDDEM 228
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 16-199 1.19e-17

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 85.62  E-value: 1.19e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  16 LLQGWDNATIAGAVLYIKKEFNLeSNPSVEgLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPN 95
Cdd:cd17435    11 LLVGYELGIISGALLQLRTLLAL-SCHEQE-MVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVS 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  96 VYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYCMVFGMSLMPSpSWRLMLGvLFIPSL 175
Cdd:cd17435    89 YTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYISNYAFANVSN-GWKYMFG-LVIPLA 166

                         170       180
                  ....*....|....*....|....
gi 1063726968 176 VFFFLTVFFLPESPRWLVSKGRML 199
Cdd:cd17435   167 ALQAIAMYFLPPSPRFLVMKDNMR 190
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 14-174 2.15e-17

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 84.79  E-value: 2.15e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  14 GNLLQGWDNATIAGAVLYIKKEFNLesNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWS 93
Cdd:cd06174     4 GFFLTGLARGLISPLLPALLQSFGL--SASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  94 PNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYCMVFGMSLMPSPSWRLMLGVLFIP 173
Cdd:cd06174    82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAAL 161


                  .
gi 1063726968 174 S 174
Cdd:cd06174   162 A 162
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
 489-713 2.20e-16

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 81.91  E-value: 2.20e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 489 TIGPAMVHPSETTKGSIWhdLHDPGVKRALVVGVGLQILQQFSGINGVLYYTPQILEQAGVGI---LLSNmgissssasl 565
Cdd:cd17361   174 SLGLAAVPALILLLGSLF--LPETPNSPQLVIAILIPFFQQLTGINVIMFYAPVLFQTLGFGSdasLISA---------- 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 566 lisALTTFVMLPAIAVAMRLMDLSGRRTLLLTTIPILIASLLVLVIsnLVHMNSIVHAVLST---VSVVLYFCFFVMGF- 641
Cdd:cd17361   242 ---VITGAVNVVSTLVSIYLVDRFGRRFLLLEGGVQMLASQVAIGI--LLAVKFGDGGELPKayaIAVVVLICLYVAAFa 316

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063726968 642 ---GPAPNILCSEIFPTRVRGICIAICALTFWICDIIVTYSLPVLLKSIGlAGVFGMYAIVCCISWVFVFIKVPE 713
Cdd:cd17361   317 wswGPLGWLVPSEIFPLETRSAGQSLTVAVNFLFTFVIAQAFLSMLCAMK-FGIFLFFAGWVVVMSLFVYFLLPE 390
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 504-716 8.53e-16

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 80.35  E-value: 8.53e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 504 SIWHDLHDPGVKRALVVGVGLQILQQFSGINGVLYYTPQILEQAGVgillsnmgisSSSASLLISALTTFVMLPAIAVAM 583
Cdd:cd17432   245 SVLELFRDRSVRWQLISIIVLMAGQQLCGINAIYFYADSIFLEAGI----------PEDKIQYVTVGTGACEVLATITCV 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 584 RLMDLSGRRTLLLTTIPILIASLLVLVISNLVHMNSIVHAVLSTVSVVLYFCFFVMGFGPAPNILCSEIFPTRVRGICIA 663
Cdd:cd17432   315 LVIERLGRRPLLIGGFGLMAVWCAVLTVALSLQNTVSWMPYLSIVCIFAYIASFGIGPAGVPFILTTEIFDQSSRPAAFM 394

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1063726968 664 ICALTFWICDIIVTYSLPVLLKSIGlAGVFGMYAIVCCISWVFVFIKVPETKG 716
Cdd:cd17432   395 VAGSLNWLSNFLVGLLFPFIQEGLG-AYCFLVFAVICLLTAIYIFFVLPETKG 446
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 62-217 1.77e-15

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 79.11  E-value: 1.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  62 CSGGVA-----DWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTL 136
Cdd:cd17434    55 AAGGLSamflnDRLGRKLSIMFSAVPSALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISHPGVRGALGAC 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 137 PQFTGSGGMFLSYcmVFGMsLMPspsWRLMLGVLFIPsLVFFFLTVFFLPESPRWLVSKGRMLEAKRVLQRLRGRE-DVS 215
Cdd:cd17434   135 PQIMAVFGSLALY--ALGL-LLP---WRWLAVAGEVP-VVIMILLLCFMPNSPRFLISKGKDEKALKALAWLRGPNtDYM 207


                  ..
gi 1063726968 216 GE 217
Cdd:cd17434   208 TE 209
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 53-209 3.04e-15

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 79.29  E-value: 3.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  53 LIGATLIttcsGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGL 132
Cdd:TIGR00898 141 LLGSFVF----GYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAI 216

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063726968 133 LNTLPQFTGSGG-MFLSYCMVFgmslmpSPSWRLMLGVLFIPSLVFFFLTVFFlPESPRWLVSKGRMLEAKRVLQRLR 209
Cdd:TIGR00898 217 VGTLIQVFFSLGlVLLPLVAYF------IPDWRWLQLAVSLPTFLFFLLSWFV-PESPRWLISQGRIEEALKILQRIA 287
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 54-212 6.04e-15

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 77.61  E-value: 6.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  54 IGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLL 133
Cdd:cd17433    52 LGAAAGGVLGGWIVDRAGRKLSLMLCSVPFIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTL 131

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063726968 134 NTLPQFTGSGGMFLSYcmVFGMSLmpspSWRLMLGVLFIPSlVFFFLTVFFLPESPRWLVSKGRMLEAKRVLQRLRGRE 212
Cdd:cd17433   132 GSCVQLMVVIGIMGAY--LAGLVL----DWRWLAVLGSIPP-TLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLRGPD 203
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
14-174 1.28e-14

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 76.06  E-value: 1.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  14 GNLLQGWDNATIAGAVLYIKKEFNLesNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWS 93
Cdd:COG2271    18 AYFLNYLDRSNLSVAAPPLQADLGL--SAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFA 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  94 PNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYcmVFGMSLMPSPSWRLMLGVLFIP 173
Cdd:COG2271    96 TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAP--PLLGWLLAAFGWRAAFLILGLP 173


                  .
gi 1063726968 174 S 174
Cdd:COG2271   174 G 174
MFS_1 pfam07690
Major Facilitator Superfamily;
14-205 4.10e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 74.38  E-value: 4.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  14 GNLLQGWDNATIAGAV-LYIKKEFNLesNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLW 92
Cdd:pfam07690   4 AAFLAALGRSLLGPALpLLLAEDLGI--SPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  93 SPNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSycMVFGMSLMPSPSWRLMLGVLFI 172
Cdd:pfam07690  82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALG--PLLGGLLASLFGWRAAFLILAI 159

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1063726968 173 PSLVFFFLTVFFLPESPRWLVSKGRMLEAKRVL 205
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEARLSLIV 192
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 15-167 4.81e-14

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 74.16  E-value: 4.81e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  15 NLLQGWDnATIAGAVL-YIKKEFNLesNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWS 93
Cdd:cd17365     8 IVLDGFD-LAVMGFVApALAQDWGL--SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFA 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063726968  94 PNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLpQFTG--SGGMFLSYcmvFGMSLMPSPSWRLML 167
Cdd:cd17365    85 QSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTL-MFCGypLGAALGGF---LAAALIPAFGWRSVF 156
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 518-722 1.25e-13

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 73.29  E-value: 1.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 518 LVVGVGLQILQQFSGINGVLYYTPQILEQAGvgiLLSNMGISSSSASLLISALTTFVmlPAIAvamrLMDLSGRRTLLLT 597
Cdd:cd17435   193 LLIGLTLVFFVQITGQPNILFYASTVLKSVG---FQSNEAASLASTGVGVVKVVSTI--PAIF----LVDKVGSKTFLCI 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 598 TIPILIASLLVLVISnlvhmnsivhavLSTVSVVLYFCFFVMGFGPAPNILCSEIFPTRVRGICIAICALTFWICDIIVT 677
Cdd:cd17435   264 GSSVMAVSLVTMGLW------------LSLASLLVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLIS 331

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1063726968 678 YSLPVLLKSIGLAGVFGMYAIVCCISWVFVFIKVPETKGMPLEVI 722
Cdd:cd17435   332 LTFLTVTELIGLPWVCFIYTAMSLASLVFVIMFVPETKGCSLEQI 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
23-148 5.87e-13

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 70.77  E-value: 5.87e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  23 ATIAGAVLYIKKEFNLesNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLG 102
Cdd:COG2814   225 ALFTYLPLYLQEVLGL--SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLA 302

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1063726968 103 RLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLS 148
Cdd:COG2814   303 LFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 14-174 7.53e-13

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 70.60  E-value: 7.53e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  14 GNLLQGWDNATIAGAVLYIKKEFNLeSNPSVEGLIVAMsLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWS 93
Cdd:cd17436     9 GGLTFGYELGIISGALLQLQTDFSL-SCFEQEALVSAL-LIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILTLA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  94 PNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYCMVFGMSLMPSpSWRLMLGVLFIP 173
Cdd:cd17436    87 GSFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYALNYFFSNVLT-GWRYMFGLAIIP 165


                  .
gi 1063726968 174 S 174
Cdd:cd17436   166 A 166
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 30-131 1.41e-12

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 69.91  E-value: 1.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  30 LYIKKefnLESNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFG 109
Cdd:cd17325    21 LYAES---LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLA 97

                          90       100
                  ....*....|....*....|..
gi 1063726968 110 VGLVVTLVPIYISETAPPEIRG 131
Cdd:cd17325    98 SAAVWPAAMALIADIAPPEERG 119
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 576-714 1.70e-11

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 66.53  E-value: 1.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 576 LPAIAVAMRLMDLSGRRTLLLTTIPILIASLLVLVISnlvhmnsIVHAVLSTVS-VVLY-FCFFVMGFGPAPN--ILCSE 651
Cdd:cd17364   254 VPGYWFTVFLIDRIGRKKIQMMGFFGMTIFLLILAGP-------YDHWKISTIGfFVLYgLTFFFSNFGPNTTtfIVPAE 326

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063726968 652 IFPTRVRGICIAICALTFWICDIIVTYSLPVLLKSIGLAGVFGMYAIVCCISWVFVFIKVPET 714
Cdd:cd17364   327 VFPARVRSTCHGISAASGKIGAIVGSFLFLSLTQNIGVRNVLIILAGVALLGIILTLLFPEEK 389
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 16-204 9.34e-11

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 64.30  E-value: 9.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  16 LLQGWDNATIAGAVLYIKKEFNLEsnPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPN 95
Cdd:TIGR00895  27 LMDGYDLAAMGFAAPAISAEWGLD--PVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATN 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  96 VYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLP----QFTGSGGMFLSYCMVfgmslmPSPSWRLMLGVLF 171
Cdd:TIGR00895 105 VTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMfcgyPIGAAVGGFLAGWLI------PVFGWRSLFYVGG 178

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1063726968 172 IPSLVFFFLTVFFLPESPRWLVSKGRMLEAKRV 204
Cdd:TIGR00895 179 IAPLLLLLLLMRFLPESIDFLVSKRPETVRRIV 211
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
29-173 2.80e-10

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 62.98  E-value: 2.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  29 VLYIKKEFNLesNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGF 108
Cdd:COG2223    28 APPLAEEFGL--SAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGI 105

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063726968 109 GVGLV-VTLVPiYISETAPPEIRGLLNTLpqFTGSGGMFLSYCMVFGMSLMPSPSWRLMLGVLFIP 173
Cdd:COG2223   106 GGGGSfAVGIA-LVSKWFPPDRRGLALGL--AAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGIL 168
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 39-208 2.85e-10

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 63.84  E-value: 2.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  39 ESNPSVEGLIVAMSL-IGATLIttcsGGVADWLGRRPMLILS----SILYFVGSLVMLWSpnvyVLLLGRLLDGFGVGLV 113
Cdd:TIGR01299 201 DSGKGMLGLIVYLGMmVGAFFW----GGLADKLGRKQCLLIClsvnGFFAFFSSFVQGYG----FFLFCRLLSGFGIGGA 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 114 VTLVPIYISETAPPEIRG-LLNTLPQFTGSGGMFLS---------YCMVFGM-SLMPSPSWRLMLGVLFIPSlVFFFLTV 182
Cdd:TIGR01299 273 IPIVFSYFAEFLAQEKRGeHLSWLCMFWMIGGIYAAamawaiiphYGWSFQMgSAYQFHSWRVFVIVCAFPC-VFAIGAL 351

                         170       180
                  ....*....|....*....|....*.
gi 1063726968 183 FFLPESPRWLVSKGRMLEAKRVLQRL 208
Cdd:TIGR01299 352 TFMPESPRFFLENGKHDEAWMILKLI 377
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
16-172 7.06e-10

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 61.79  E-value: 7.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  16 LLQGWDNATIAGAVLYIKKEFNLesNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPN 95
Cdd:COG0738    18 FLWGFATALWGPLIPALKDAFGL--SDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063726968  96 VYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYCMVFGMSLMPSPSWRLMLGVLFI 172
Cdd:COG0738    96 YPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAV 172
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 30-131 1.07e-09

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 61.07  E-value: 1.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  30 LYIKkefNLESNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFG 109
Cdd:cd17489    21 LYAH---DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIG 97

                          90       100
                  ....*....|....*....|..
gi 1063726968 110 VGLVVTLVPIYISETAPPEIRG 131
Cdd:cd17489    98 WGAFTTAAATLVADIIPPSRRG 119
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
24-174 1.62e-09

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 60.66  E-value: 1.62e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  24 TIAGAVL-YIKKEFNLesNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLG 102
Cdd:COG2807    35 TSVGPLLpEIRADLGL--SATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAG 112

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063726968 103 RLLDGFGVGLVVTLVPIYISETApPEIRGLLNTLPQFTGSGGMFLSycMVFGMSLMPSPSWRLMLGVLFIPS 174
Cdd:COG2807   113 TALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALA--AGLTVPLAAALGWRGALAVWALLA 181
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 39-208 2.21e-09

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 60.43  E-value: 2.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  39 ESNPSVEGLIVAMSL-IGATLIttcsGGVADWLGRRPMLILS----SILYFVGSLVMLWSpnvyVLLLGRLLDGFGVGLV 113
Cdd:cd17439    33 DSNKGMLGLIVYLGMmVGAFLW----GGLADRIGRRQCLLISlsvnSVFAFFSSFVQGYG----TFLFCRLLSGVGIGGS 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 114 VTLVPIYISETAPPEIRG-LLNTLPQFTGSGGMFLS---------YCMVFGM-SLMPSPSWRLMLGVLFIPSlVFFFLTV 182
Cdd:cd17439   105 IPIVFSYFSEFLAQEKRGeHLSWLCMFWMIGGIYASamawaiiphYGWSFQMgSAYQFHSWRVFVLVCAFPS-VFAIGAL 183

                         170       180
                  ....*....|....*....|....*.
gi 1063726968 183 FFLPESPRWLVSKGRMLEAKRVLQRL 208
Cdd:cd17439   184 TTMPESPRFFLENGKHDEAWMVLKQV 209
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 14-131 3.35e-09

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 59.71  E-value: 3.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  14 GNLLQGWDNATIAGAVLYIKKEFNLesnpsveGLIVAMSLIGATLITTCSGG-----VADWLGRRPMLILSSILYFVGSL 88
Cdd:PRK03893   28 GYLLDGFDFVLITLVLTEVQGEFGL-------TTVQAASLISAAFISRWFGGlllgaMGDRYGRRLAMVISIVLFSVGTL 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1063726968  89 VMLWSPNVYVLLLGRLLDGFGV----GLVVTlvpiYISETAPPEIRG 131
Cdd:PRK03893  101 ACGFAPGYWTLFIARLVIGMGMageyGSSAT----YVIESWPKHLRN 143
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 40-208 3.68e-09

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 59.81  E-value: 3.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  40 SNPSVEGLIVAMSL-IGATLIttcsGGVADWLGRRPMLILS----SILYFVGSLVMLWSpnvyVLLLGRLLDGFGVGLVV 114
Cdd:cd17363    34 SNKGMLGLIVYLGMmVGAFVW----GGLADKLGRKQCLLIAlsvnGVFAFLSSFVQGYG----FFLFCRLLSGIGIGGSI 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 115 TLVPIYISETAPPEIRG-LLNTLPQFTGSGGMFLS---------YCMVFGM-SLMPSPSWRLMLGVLFIPSLVFFFLTVF 183
Cdd:cd17363   106 PIVFSYFAEFLAREKRGeHLSWLCMFWMIGGLYASamawaiiphYGWGFSMgTAYQFHSWRVFVIVCALPSVASVVALTF 185

                         170       180
                  ....*....|....*....|....*
gi 1063726968 184 FlPESPRWLVSKGRMLEAKRVLQRL 208
Cdd:cd17363   186 M-PESPRFLLEVGKHDEAWMILKQV 209
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 40-208 5.87e-09

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 59.17  E-value: 5.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  40 SNPSVEGLIVAMSLIGATLITtcsGGVADWLGRRPMLILS----SILYFVGSLVMLWSpnvyVLLLGRLLDGFGVGLVVT 115
Cdd:cd17438    34 SNKGMLGLIVYLGMMAGAFIW---GGLADKLGRKRCLIISlainASFAFLSSFVQGYG----AFLFCRLISGFGIGGSLP 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 116 LVPIYISETAPPEIRG-LLNTLPQFTGSGGMflsYCMVFGMSLMPS-------------PSWRLMLGVLFIPSLVFFFLT 181
Cdd:cd17438   107 IVFAYFSEFLAREKRGeHLSWLCMFWMIGGL---YASAMAWSIIPHygwgfsmgtnyhfHSWRVFVIICALPCIASIIAL 183

                         170       180
                  ....*....|....*....|....*..
gi 1063726968 182 VFFlPESPRWLVSKGRMLEAKRVLQRL 208
Cdd:cd17438   184 KFM-PESPRFLLEMGKHDEAWMILKNI 209
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 30-131 7.69e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 58.36  E-value: 7.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  30 LYIKKEFNLesNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFG 109
Cdd:cd17325   224 LYAAELGGL--SPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLG 301

                          90       100
                  ....*....|....*....|..
gi 1063726968 110 VGLVVTLVPIYISETAPPEIRG 131
Cdd:cd17325   302 LGLVFPATLALLADIVPPEGRG 323
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 41-148 8.84e-09

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 57.97  E-value: 8.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  41 NPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGVGLVVTLVPIY 120
Cdd:cd17473   231 SAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSW 310

                          90       100
                  ....*....|....*....|....*...
gi 1063726968 121 ISETAPPEIRGLLNTLPQFTGSGGMFLS 148
Cdd:cd17473   311 AMSLVPPELRGRAMGIVTSAFFLGQFLS 338
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 14-165 9.59e-09

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 58.07  E-value: 9.59e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  14 GNLLQGWDNATIAGAVLYIKKEFNLESNPSVEGLIVA--------MSLIGATLIttcsGGVADWLGRRPMLILSSILYFV 85
Cdd:cd17367     7 GNLVEWYDWYVYAAFALYFAPQFFPSGDPTVALLSTAavfavgflMRPIGGWLF----GRLADRIGRRAALTLSVSLMAA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  86 GSLVM----------LWSPnvYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYCMVFGM 155
Cdd:cd17367    83 GSLVIavtptyatigIWAP--IILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVL 160

                         170
                  ....*....|....*.
gi 1063726968 156 SL------MPSPSWRL 165
Cdd:cd17367   161 QHtlgedqMAAWGWRI 176
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 516-702 1.20e-08

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 57.61  E-value: 1.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 516 RALVVGVGLQILQQFsGINGVLYYTPQILEQAGvGILLSNMGISSSSasllisalTTFVMLPAIAVAMRLMDLSGRRTLL 595
Cdd:cd17316   177 RRTLLLILLWFFISF-GYYGLTTFLPTYLQTVL-GLSPATSSLYLLL--------ISLGALVGALIAGLLSDRIGRKKTL 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 596 LTTIPILIASLLVLVIsNLVHMNSIVHAVLSTVSvvlyfcFFVMGFGPAPNILCSEIFPTRVR----GICIAICALTFwi 671
Cdd:cd17316   247 VIGLILSGILALPLFY-LLSGSPTLLLLLLFILS------FFVGGVWGALYAYLAELFPTEVRatgvGLSYNLGRLGG-- 317

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1063726968 672 cdIIVTYSLPVLLKSIGLAGVFGMYAIVCCI 702
Cdd:cd17316   318 --GGAPPLIALLLASTGGTGVPALILALLAI 346
2_A_01_02 TIGR00880
Multidrug resistance protein;
46-159 6.04e-08

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 52.27  E-value: 6.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  46 GLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGVGLVVTLVPIYISETA 125
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1063726968 126 PPEIRGLLNtlpqftgsggMFLSYCMVFGMSLMP 159
Cdd:TIGR00880  81 PPEERGVAL----------GLMSAGIALGPLLGP 104
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 23-123 8.02e-08

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 54.89  E-value: 8.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  23 ATIAGAVLYIKKEFNLESNPSVeGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLG 102
Cdd:cd17473    16 AAIAPALPAIAQHFVPNSELLV-PLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLAS 94

                          90       100
                  ....*....|....*....|.
gi 1063726968 103 RLLDGFGVGLVVTLVPIYISE 123
Cdd:cd17473    95 RALLGIGVAGIMTLATALIGD 115
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 46-131 1.11e-07

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 54.48  E-value: 1.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  46 GLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGVGLVVTLVPIYISETA 125
Cdd:cd17324    37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLV 116


                  ....*.
gi 1063726968 126 PPEIRG 131
Cdd:cd17324   117 PPEKRG 122
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 30-130 1.12e-07

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 54.51  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  30 LYIKKEFNLESNPSVEGLIVA----MSLIGATLIttcsGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLL 105
Cdd:cd17330    21 FYVREFNKLGASGYYVGLLQSsyslGQFLASPLW----GRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFL 96

                          90       100
                  ....*....|....*....|....*
gi 1063726968 106 DGFGVGLVVTlVPIYISETAPPEIR 130
Cdd:cd17330    97 DGLTGGNVSV-AQAYIADITDEEER 120
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
28-172 1.64e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 54.11  E-value: 1.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  28 AVLYIKKEFNLesNPSVEGLIVAMSLIGATLITTCSGGVADWLGRR--PMLILSSILYFVGSLVMLWSPNVYVLLLGRLL 105
Cdd:COG2271   203 LPTYLVEVRGL--SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFL 280

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063726968 106 DGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYcMVFGMsLMPSPSWRLMLGVLFI 172
Cdd:COG2271   281 AGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGP-LLVGY-LLDATGYQAAFLLLAA 345
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
572-715 2.05e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 53.72  E-value: 2.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 572 TFVMLPAIAVAMRLMDLSGRRTLLLTTIPILIASLLVLVISNLVHMnsivhavlsTVSVVLYFCFFVMGFGPAPNI--LC 649
Cdd:COG2271   226 FLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSP---------ALAIALLFLAGFGLGGAFGLLwaLA 296

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063726968 650 SEIFPTRVRGICIAICALTFWICDIIVTYSLPVLLKSIGLAGVFGMYAIVCCISWVFVFIKVPETK 715
Cdd:COG2271   297 AELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 22-169 2.86e-07

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 53.33  E-value: 2.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  22 NATIAGAVL-YIKKEFNLesNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLL 100
Cdd:cd17321    11 DVTIVNVALpTIARDLGA--SPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLI 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 101 LGRLLDGFGVGLVVTLVPIYISETAPPEIRGL-LNTLPQFTGSGGMFlsyCMVFGMSLMPSPSWRLMLGV 169
Cdd:cd17321    89 AARALQGIGAAAIMPASLALIAATFPGERRGRaLGLWGAVVGIGAAL---GPLLGGLLLELFGWRWIFLI 155
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 28-165 3.25e-07

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 53.30  E-value: 3.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  28 AVLYIKKEFNLESNPSVeGLIVAMSLIGATLITTCSGGV-----ADWLGRRPMLILSSILYFVGSLVM----------LW 92
Cdd:cd17369    25 AALVFNKLFFPAVDPAA-GTLAAFATFGVGFLARPLGGVvfghfGDRIGRKKTLVLTLLLMGIATFLIgllptyaqigIL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  93 SPNVYVLLlgRLLDGFGVG-------LVVTlvpiyisETAPPEIRGLLNTLPQFTGSGGMFLSYCMVFGMSLMPSPS--- 162
Cdd:cd17369   104 APILLVLL--RLLQGLALGgewggavLMAV-------EHAPPKRRGFYGSFPQLGAPVGLLLATGVFLLLSALLSDEafl 174


                  ....*.
gi 1063726968 163 ---WRL 165
Cdd:cd17369   175 swgWRI 180
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 46-132 3.55e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 52.99  E-value: 3.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  46 GLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLV--MLWSPNVYVLLLGRLLDGFGVGLVVTLVPIYISE 123
Cdd:cd17316   216 SLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPlfYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAE 295


                  ....*....
gi 1063726968 124 TAPPEIRGL 132
Cdd:cd17316   296 LFPTEVRAT 304
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 52-174 5.47e-07

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 52.36  E-value: 5.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  52 SLIGATLIttcsGGVAD-WLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIR 130
Cdd:cd17378    46 CLIGSGVL----GHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLATEPVGPKWR 121

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1063726968 131 GLLNTLPQFTGSGG-MFLSycmvfGMSLMPSPSWRLMLGVLFIPS 174
Cdd:cd17378   122 GQVGMSTFFFFVLGfMSLP-----GIAYLNGSSWRVLYFWTSIPA 161
MFS_MFSD5_like cd17487
Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily ...
 55-112 6.95e-07

Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily domain containing 5 protein (MFSD5) is also called molybdate-anion transporter, or molybdate transporter 2 homolog (MOT2). It acts as an atypical solute carrier (SLC) that mediates high-affinity intracellular uptake of the rare oligo-element molybdenum. It may also play a role in maintaining the glucose homeostasis and pancreatic beta-cell proliferation, as well as in altered energy homeostasis. MFSD5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341040  Cd Length: 385  Bit Score: 52.22  E-value: 6.95e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063726968  55 GATLI-TTCSGGVADWLGRRPMLILSSILYFVGSLVMLwSPNVYVLLLGRLLDGFGVGL 112
Cdd:cd17487    49 GSSVVfGTFVGSLADKFGRKRACLLFCVLYSLSCLTKH-SPNFGVLLLGRVLGGISTSL 106
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 32-174 7.63e-07

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 52.15  E-value: 7.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  32 IKKEFNLESNPsvEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGVG 111
Cdd:cd17372    25 VQCEWNLSAWQ--VALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLG 102

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063726968 112 LVVTLVPIYiSETAPPEIRGLLNTLPQ-FTGSGGMFLSYCMVFgmsLMPSPSWRLMLGVLFIPS 174
Cdd:cd17372   103 GGPQLASWY-LEFLPAKSRGTWMVLFSvFWTVGTIFEASLAWL---VMPRLGWRWLLAFSSVPS 162
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 64-208 8.40e-07

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 52.22  E-value: 8.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  64 GGVADWLGRRPMLI----LSSILYFVGSLVMLWSpnvyVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRG-LLNTLPQ 138
Cdd:cd17440    55 GGLADKVGRRQSLLicmsVNGFFAFLSSFVQGYG----LFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGeHLSWLCM 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 139 FTGSGGMFLS---------YCMVFGM-SLMPSPSWRLMLGVLFIPSlVFFFLTVFFLPESPRWLVSKGRMLEAKRVLQRL 208
Cdd:cd17440   131 FWMIGGIYASamawaiiphYGWSFSMgSAYQFHSWRVFVIVCALPC-VSSVVALTFMPESPRFLLEVGKHDEAWMILKQI 209
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 53-173 8.48e-07

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 51.81  E-value: 8.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  53 LIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGL 132
Cdd:cd17317    35 FLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSF 114

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1063726968 133 LNTLPQFTGSGGMflsycMVFGMSLMPSPSWRL------MLGVLFIP 173
Cdd:cd17317   115 VGILFGLFWALGY-----MLLALLAYLIRDWRWlqlaisLPGLLFLL 156
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 22-136 9.23e-07

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 51.81  E-value: 9.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  22 NATIAGAVL-YIKKEFNlESNPSVEGLIVAMSLIGATLITTcSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLL 100
Cdd:cd17503    11 DTTIVNVALpTIMGDLG-ASLDTVQWVITSYLLALAIMIPL-SGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLI 88

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1063726968 101 LGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTL 136
Cdd:cd17503    89 IFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGL 124
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 23-149 1.09e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 51.46  E-value: 1.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  23 ATIAGAVLYIKKEFNLesNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLG 102
Cdd:cd06173   226 ALTVLLPLLAKEVLGG--GAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAA 303

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1063726968 103 RLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSY 149
Cdd:cd06173   304 LFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGA 350
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
 20-147 1.16e-06

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 51.39  E-value: 1.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  20 WDNATIAGAVLYIKKEFNLESNPSVEGLIVAMSL----IGATLITTCsggVADWLGRRPMLILSSILYFVGSLVMLWSPN 95
Cdd:cd17444    12 RDYRIRAGLVQNIVSKWDLVCDSSWKVHIAKFSLlvglIFGYLITGC---LADWFGRRPVLLFSVVFILIFGLTVALSVN 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1063726968  96 VYVLLLGRLLDGFGV-GLVVTLVPIYIsETAPPEIRGLLNTLPQFTGSGGMFL 147
Cdd:cd17444    89 VTMFSTLRFFEGFCLaGIILSLYALRI-ELCPPGHRFMITMVASFIAMAGQFL 140
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 14-133 1.35e-06

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 51.03  E-value: 1.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  14 GNLLQGWDNATIAGAVLYIKKEFNLESNpsveglivaMSLIG-ATLITTCS-----GGVADWLGRRPMLILSSILYFVGS 87
Cdd:cd17502     4 ALFLAALDQTIVATALPTIVAEFGGLSL---------VSWVGtAYLLTSTAfqpiyGKLSDLFGRKWVLLIAIVIFELGS 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1063726968  88 LVMLWSPNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLL 133
Cdd:cd17502    75 LLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKY 120
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
22-173 2.41e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 50.67  E-value: 2.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  22 NATIAGAVLYIKKeFNLESNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSP--NVYVL 99
Cdd:COG2211   244 LALVAALLLYYFK-YVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLL 322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 100 LLGRLLDGFGVGLVVTLVPIYISETAPPE--------------IRGLLNTLPQFTGS--GGMFLSYC-MVFGMSLMPSPS 162
Cdd:COG2211   323 LVLAALAGIGLGAILVLPWAMLADVVDYDewktgrrreglyfgIFTFAIKLGQALAGalAGLLLALFgYVAGAAQSPSAL 402

                         170
                  ....*....|.
gi 1063726968 163 WRLMLGVLFIP 173
Cdd:COG2211   403 TGIRLLFFLLP 413
MFS_1 pfam07690
Major Facilitator Superfamily;
46-148 3.29e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 49.72  E-value: 3.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  46 GLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSP---NVYVLLLGRLLDGFGVGLVVTLVPIYIS 122
Cdd:pfam07690 238 GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSltlSSLWLLLALLLLGFGFGLVFPALNALVS 317

                          90       100
                  ....*....|....*....|....*.
gi 1063726968 123 ETAPPEIRGLLNTLPQFTGSGGMFLS 148
Cdd:pfam07690 318 DLAPKEERGTASGLYNTAGSLGGALG 343
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
 14-173 4.16e-06

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 49.68  E-value: 4.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  14 GNLLQGWDNATIAGAVLYIKKEFnLESNPSVEGLIVAMSLIGATLITTCSGGV-----ADWLGRRPMLILSSILYFVGSL 88
Cdd:cd17368     7 GNALEFFDFGVYGFFAVYIGRLF-FPSGSEFASLLLTFATFGVGFFMRPIGAIvlgayADRIGRKPAMTLTLAIMALGTL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  89 VM----------LWSPnvYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQF------TGSGGMFLSYCMV 152
Cdd:cd17368    86 LIalaptyatigIAAP--LLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSAsqqvaiVAGALVGYLLSLT 163

                         170       180
                  ....*....|....*....|...
gi 1063726968 153 FGMSLMPSPSWR--LMLGVLFIP 173
Cdd:cd17368   164 LTAEALAEWGWRipFFIGLLIIP 186
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 64-121 4.74e-06

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 49.50  E-value: 4.74e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063726968  64 GGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGVGLVVTLVPIYI 121
Cdd:cd17320    55 GPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIV 112
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 32-128 5.19e-06

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 49.50  E-value: 5.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  32 IKKEFNleSNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGVG 111
Cdd:cd17504    22 IQREFG--TSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGA 99

                          90
                  ....*....|....*..
gi 1063726968 112 lVVTLVPIYISETAPPE 128
Cdd:cd17504   100 -VFPLAFALVREEFPPE 115
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 573-705 5.84e-06

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 49.12  E-value: 5.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 573 FVMLPAIAVAMRLMDLSGRRTLLLTTIPIL-IASLLVLVISNLVHMNSIVHAVLSTVSVVLyfCFFVMgfgpapNILCSE 651
Cdd:cd17317   202 LVEIPAYFLALLLLDRLGRRWTLSGSLLLAgLACLVTALLPDDENTLALTLALVGKFAISA--AFSVI------YLYTAE 273

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1063726968 652 IFPTRVRGICIAICALTFWICDIIVTYSlpVLLKSIGLagvFGMYAIVCCISWV 705
Cdd:cd17317   274 LYPTVVRNTGVGLCSTVARVGAILAPFI--VLLGKIGP---LLPLIIFGVLALL 322
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
28-159 7.99e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 48.70  E-value: 7.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  28 AVLYIKKEFNLesNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDG 107
Cdd:COG0738   233 LPLYLKDVLGL--SEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVG 310

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1063726968 108 FGVGLVvtlVPIYISETappeirglLNTLPQFTGSGGMFLSYCMVFGMSLMP 159
Cdd:COG0738   311 LGLSLM---FPTIFSLA--------LDGLGKRTAAAVSAVLIMGIVGGAIGP 351
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 42-148 1.07e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 48.32  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  42 PSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGVGLVVTLVPIYI 121
Cdd:cd17477    30 TALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWL 109

                          90       100
                  ....*....|....*....|....*..
gi 1063726968 122 SETAPPEIRGLLNTLPQFTGSGGMFLS 148
Cdd:cd17477   110 NALATNENRGRVLGLYSTVLGLGFALG 136
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 35-172 1.40e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 47.95  E-value: 1.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  35 EFNLESNPSVEGLIvaMSLIGATLITTcSGGVADWLGRRPM----LILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGV 110
Cdd:cd17474   226 ELLYGISPIIIGLL--FAGWSVLLALG-SLFVGRLLKKRFGarriLVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGL 302

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063726968 111 GLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSyCMVFGMsLMPSPSWRLMLGVLFI 172
Cdd:cd17474   303 GLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVG-PLLFGL-LLEIFGLSAPFLVGAA 362
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 64-115 1.55e-05

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 47.76  E-value: 1.55e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1063726968  64 GGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGV--GLVVT 115
Cdd:TIGR00710  61 GPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGAsaGSVIS 114
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
571-715 1.74e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 47.66  E-value: 1.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 571 TTFVMLPAIAVAMRLMDLSGRRtlllttiPILIASLLVLVISNLVhmnsivhAVLSTVSVVLYFCFFVMGFG-----PAP 645
Cdd:COG2814    54 YLLGAALGAPLAGRLADRFGRR-------RVLLLGLLLFALGSLL-------CALAPSLWLLLAARFLQGLGagalfPAA 119

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 646 NILCSEIFPTRVRGICIAICALTFWICDIIVTYSLPVLLKSIGLAGVFGMYAIVCCISWVFVFIKVPETK 715
Cdd:COG2814   120 LALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESR 189
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 46-135 1.83e-05

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 48.01  E-value: 1.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  46 GLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGVGLVVtLVPIYISETA 125
Cdd:cd06179    35 TWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQG-LGAAVASELV 113

                          90
                  ....*....|
gi 1063726968 126 PPEIRGLLNT 135
Cdd:cd06179   114 PNKYRGLVQG 123
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 42-136 3.06e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 46.77  E-value: 3.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  42 PSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGVGLVVTLVPIYI 121
Cdd:cd17324   233 SSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRV 312

                          90
                  ....*....|....*
gi 1063726968 122 SETApPEIRGLLNTL 136
Cdd:cd17324   313 LRLA-PEARGLASSL 326
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
25-172 3.12e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 46.80  E-value: 3.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  25 IAGAVLYIKKEFNLEsnPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSP-NVYVLLLGR 103
Cdd:COG2223   225 SSWLPPYLVDQFGLS--AATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLF 302

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 104 LLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGS-GGMFLSYcmVFGMSLMPSPSWRLMLGVLFI 172
Cdd:COG2223   303 LLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGlGGFLGPL--LFGALLDATGSYTAAFLVFAV 370
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 42-172 3.21e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.04  E-value: 3.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  42 PSVEGLIVAMSLIGATLITTCSGGVAD-WLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGVGLVVTLVPIY 120
Cdd:cd06174   238 VAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFAL 317

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1063726968 121 ISETAPPEIRGLLNTLPQFTGSGGMFLSYcMVFGMSLMPSPSWRLMLGVLFI 172
Cdd:cd06174   318 IAELFPPEIRGTAFGLLNTFGFLGGAIGP-LLAGFLLAATFGLTGAFLVLAV 368
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 21-174 5.31e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 46.02  E-value: 5.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  21 DNATIAGAVLYIKKEFNLesNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLL 100
Cdd:cd17319    18 DRVNISVAAPTIMKDLGL--SPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLY 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063726968 101 LGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTL-PQFTGSGGMFLSYCMVFgmsLMPSPSWRLMLGVLFIPS 174
Cdd:cd17319    96 VLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLfNSGAPLGAAIGPPLSGW---LLLLFGWRWAFIIEGLLG 167
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 46-147 8.30e-05

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 45.39  E-value: 8.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  46 GLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGVGLVVTLVPIYISETA 125
Cdd:cd17333    34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALF 113

                          90       100
                  ....*....|....*....|..
gi 1063726968 126 PPEIRGLLNTLPQFTGSGGMFL 147
Cdd:cd17333   114 EESSATRLNVLHGFFGLGALIG 135
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 46-197 1.10e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 45.37  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  46 GLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGVGLVVTLVPIYISETA 125
Cdd:cd17371    37 GLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYV 116

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063726968 126 PPEIRGLLNTLPQFTGSGGMFL---SYCMVFGMsLMPSPSWRLMLGVLFIPSlVFFFLTVFFLPESPRWLVSKGR 197
Cdd:cd17371   117 PARHRGKALGYVQSGWAVGWLLatlLAALLFPL-LPPEIAWRVLFLLGALPA-LLVLFIRRFVKEPPQWQAARAA 189
MFS_1 pfam07690
Major Facilitator Superfamily;
572-715 1.29e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 44.72  E-value: 1.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 572 TFVMLPAIAVAMRLMDLSGRRtlllttiPILIASLLVLVISNLVhmnsivhAVLSTVSVVLYFCFFVMGFG-----PAPN 646
Cdd:pfam07690  42 SLGYALAQPLAGRLSDRFGRR-------RVLLIGLLLFALGLLL-------LLFASSLWLLLVLRVLQGLGagalfPAAL 107

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063726968 647 ILCSEIFPTRVRGICIAICALTFWICDIIVTYSLPVLLKSIGLAGVFGMYAIVCCISWVFVFIKVPETK 715
Cdd:pfam07690 108 ALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPE 176
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
46-147 1.41e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 44.86  E-value: 1.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  46 GLIVAMSLIGATLIttcsGGVADWLG-RRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLdGFGVGLVVTLVPIYISET 124
Cdd:COG2807   257 SLFQLAGIPGSLLV----PLLADRLGdRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLL-GLGQGGLFPLALTLIGLR 331

                          90       100
                  ....*....|....*....|....
gi 1063726968 125 AP-PEIRGLLNTLPQFTGSGGMFL 147
Cdd:COG2807   332 ARtPAEAAALSGMAQSVGYLLAAL 355
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 29-148 1.53e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 44.49  E-value: 1.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  29 VLYIKKEFNLesNPSVEGLIvaMSLIGATLITTcSGGVADWL----GRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRL 104
Cdd:cd17330   198 SLFLKDRFGF--SPSQIGLL--LALVGIAGILA-QLLLIPRLakrlGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAA 272

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1063726968 105 LDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLS 148
Cdd:cd17330   273 ILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIG 316
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 51-130 1.74e-04

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 44.55  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  51 MSLIGATLIttcsGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFgVGLVVTLVPIYISETAPPEIR 130
Cdd:cd17388    50 MQFIFAPIL----GALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGI-TGATGAVAAAYIADVTPPEQR 124
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 64-170 2.51e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 44.07  E-value: 2.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  64 GGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGllntlpqfTGSG 143
Cdd:cd17370   255 GRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRG--------TAYG 326

                          90       100
                  ....*....|....*....|....*..
gi 1063726968 144 gmflSYCMVFGMSLMPSPswrLMLGVL 170
Cdd:cd17370   327 ----LFNTVVGIGWLLAS---LIAGYL 346
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 571-715 2.51e-04

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 44.21  E-value: 2.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 571 TTFVMLPAIAVAMRLMDLSGR------RTLLLTTIPILIASLLVLVISNLVHMNSIVHA-VLSTVSVVlyfcfFVMGFGP 643
Cdd:cd17367   261 ATWITTAALLVFMLLQPLGGRlsdrigRRPLLLFFGIGGTLATVPLLSALDHTDSPYTAfALVLVGLV-----FLSGYTS 335

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063726968 644 APNILCSEIFPTRVRGICIAIC-ALTFWICDIIVTYsLPVLLKSIGLAGVFGMYAIVCCISWVFVFIKVPETK 715
Cdd:cd17367   336 INAVVKAELFPTHVRALGVGLPyALAVAIFGGTAPY-VALWLKSIGHEWVFFWYVAGLIAISLVVYLRMPETR 407
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 22-131 2.61e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 44.10  E-value: 2.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  22 NATIAGAVLYIKKEFNLeSNPSVEGLIVAMSLIGAtLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLL 101
Cdd:cd17474    15 VSIVDPILPAIAEALGA-SPAQVGLLITAFTLPAA-VLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLA 92

                          90       100       110
                  ....*....|....*....|....*....|
gi 1063726968 102 GRLLDGFGVGLVVTLVPIYISETAPPEIRG 131
Cdd:cd17474    93 GRALQGIGAAGLGPLALTLIGDLFEGGERA 122
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 28-136 3.31e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 43.76  E-value: 3.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  28 AVLYIKKEFNLesNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDG 107
Cdd:cd17329    22 MAIYLHQQLGL--SASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTG 99

                          90       100
                  ....*....|....*....|....*....
gi 1063726968 108 FGVGLVVTLVPIYISETAPPEIRGLLNTL 136
Cdd:cd17329   100 FGGGLFEPASEAMIADVTTPENRTRAFSL 128
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 515-658 3.44e-04

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 43.67  E-value: 3.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 515 KRALVVGVGLQILQQ---FSGINGVLYYTPQILEQAGVGILLSNMgissssasllisaLTTFVMLPAIAVAMRLMDLSGR 591
Cdd:cd17369   227 WRALLLAIGLRLAENvlfYLFTTFALSYATQTLGVDRSTVLLAVL-------------IASVVAAITIPLFGWLSDRVGR 293

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063726968 592 RTLLLTTIPILIASLLVLVISnlvhMNSIVHAVLSTVSVVLYFCFFVMGFGPAPnILCSEIFPTRVR 658
Cdd:cd17369   294 RPVYLAGALLAALFAFPFFWL----LDTGSTWLIVLAAVVVLGVLHGMMYGPQA-AFLAELFPTRVR 355
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
 47-170 3.57e-04

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 43.52  E-value: 3.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  47 LIVAMSLIGATLIttcSGGVADWLGRRPMLILSSILYFVGSL-VMLW---SPNVYVLLLGRLLDGFGVGLVVTLVPIYIS 122
Cdd:cd17368   265 LLAGVANFIWAPL---GGALSDRIGRRPVLLVITLAALVTLYpVFAWltaAPSFGRLLLVLLVLSFFFGMYGGAMVVALV 341

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1063726968 123 ETAPPEIRGLLNTLPQ------FTGSGGMFLSYCMVFGMSLMpSPSWRLMLGVL 170
Cdd:cd17368   342 ELFPVRVRSTGFSLVYalavaiFGGFAQFIVTWLIELTGSPL-APAWYLMGAAL 394
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 53-173 5.22e-04

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 42.79  E-value: 5.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  53 LIGATLIttcsGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGL 132
Cdd:cd17446    47 LVGAIVF----GGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRVRAV 122

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1063726968 133 LNTLpqftgsggmfLSYCMVFGMSLMPS-----PSWRLMLGVLFIP 173
Cdd:cd17446   123 VGTL----------LGYCYTLGQLILAGvayaiRDWRWLQLAVSLP 158
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 47-132 8.95e-04

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 42.37  E-value: 8.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  47 LIVAMSLIGATLITTcSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGVGLVVTLVPIYISETAP 126
Cdd:TIGR00711  42 VITSYMLANAISIPL-TGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYP 120


                  ....*.
gi 1063726968 127 PEIRGL 132
Cdd:TIGR00711 121 PEKRGR 126
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
 15-128 9.32e-04

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 42.23  E-value: 9.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  15 NLLQGWDNATIAGAVLYIKKEFNLESnpSVEGLIVAMSLIGATLITTCsggVADWLGR--RP-MLILSSILYFVGSLVML 91
Cdd:cd17336    12 GLLQGAVVSYFVSTITTIEKRFGLSS--SQSGLILSANDIGQLLAVLL---VSYFGGRghRPrWIGIGSILMGLGCFLLA 86

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1063726968  92 wSPnvYVLLLGRLLDGFGVGLVVTLVPIYISETAPPE 128
Cdd:cd17336    87 -LP--HFLFVGQFLLGIGSSPLYTLGITYIDDNVSKK 120
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 38-135 9.56e-04

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 42.21  E-value: 9.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  38 LESNPSVEGLIV----AMSLIGATLIttcsGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFgVGLV 113
Cdd:cd17390    26 LGASPTVIGLIGsvygALQLFSSPLV----GSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGI-FKHT 100

                          90       100
                  ....*....|....*....|....*.
gi 1063726968 114 VTLVPIYISETAPPEIR----GLLNT 135
Cdd:cd17390   101 QSLCKAYLSDLVSEQERsrvlGRFNA 126
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
 576-722 9.88e-04

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 42.41  E-value: 9.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 576 LPAIAVAMRLMDLSGRRTLLLTTIPILIASLLVLVISnlvhMNSIVHAVLstvsVVLY-FCFFVMGFGPAPN--ILCSEI 652
Cdd:TIGR00887 349 VPGYWVTVFLVDIIGRKPIQLMGFFILTVLFFVLGFA----YNHLSTHGF----LAIYvLAQFFANFGPNATtfIVPGEV 420

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 653 FPTRVRGICIAICALTFWICDIIVTYSLPVLLKS----------IGLAGVFGMYAIVCCISWVFVFIkVPETKGMPLEVI 722
Cdd:TIGR00887 421 FPTRYRSTAHGISAASGKAGAIIGQFGFLYLAQHgdptkgyptgIWMGHVLEIFALFMFLGILFTLL-IPETKGKSLEEL 499
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 42-173 1.07e-03

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 42.11  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  42 PSVE-GLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGVGLVVTLVPIY 120
Cdd:cd17441    32 PSWQvALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGGVPQSVTLY 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1063726968 121 iSETAPPEIRGLLNTLPQ-FTGSGGMFLSYCMVFgmsLMPSPSWRLMLGVLFIP 173
Cdd:cd17441   112 -AEFLPMKSRAKCILLIEvFWALGTVFEVLLAVF---VMPTLGWRWLLILSALP 161
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 47-130 1.10e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 42.13  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  47 LIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLW----SPNVYVLLLGRLLDGFGVGLVVTLVPIYIS 122
Cdd:cd17369   268 LAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWlldtGSTWLIVLAAVVVLGVLHGMMYGPQAAFLA 347


                  ....*...
gi 1063726968 123 ETAPPEIR 130
Cdd:cd17369   348 ELFPTRVR 355
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 15-171 1.21e-03

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 41.84  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  15 NLLQGWDNATIAGAVLYIKKEFNLesNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILS----SILYFVGSLVm 90
Cdd:cd17328     8 NLLNYMDRFTIAGVLPDIQSDFLI--DDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGiliwSAATLLSSFA- 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  91 lwsPNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYcmVFGmSLMPS--PSWRL--- 165
Cdd:cd17328    85 ---PNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGY--VVG-GLVAQatGGWRWafr 158


                  ....*....
gi 1063726968 166 ---MLGVLF 171
Cdd:cd17328   159 vtgVLGVLL 167
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
64-110 1.33e-03

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 41.80  E-value: 1.33e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1063726968  64 GGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGV 110
Cdd:PRK11043   62 GPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGV 108
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 43-131 1.88e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 41.13  E-value: 1.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  43 SVEGLIVAMSL--IGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVY-VLLLGRLLDGFGVGLVVTLVPI 119
Cdd:cd17371   243 SFEGSAGYLVVtiLGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPtLILILGFPLGFFASGPFSGMGA 322

                          90
                  ....*....|..
gi 1063726968 120 YISETAPPEIRG 131
Cdd:cd17371   323 YLTELFPTAVRA 334
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 63-134 2.05e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.04  E-value: 2.05e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063726968  63 SGGVADWLGRRPMLILSSILYFVGsLVMLW-SPNVYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLN 134
Cdd:cd17489   247 SGKLSDRKGPKTVIIPGLLLLALG-LLLLSfAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAAN 318
MFS_ProP cd17366
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ...
 14-165 2.34e-03

Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340924 [Multi-domain]  Cd Length: 377  Bit Score: 40.80  E-value: 2.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  14 GNLLQGWDNATIAGAVLYIKKEFNLESNPSVEGLIVAMSLIGATLITTCSGGV----ADWLGRRPMLILSSILYFVGSLV 89
Cdd:cd17366     7 GNAMEWFDFGVYGYLAVTIGKVFFPGGDPTAQLLATFATFAVAFLVRPLGGLVfgplGDKYGRQKVLAITIILMAASTFC 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  90 M----------LWSPnvYVLLLGRLLDGFGVGLVVTLVPIYISETAPPEIRGLLNTLPQFTGSGGMFLSYCMVFGMSL-- 157
Cdd:cd17366    87 IgllptyatigVWAP--ILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLLTLll 164

                         170
                  ....*....|..
gi 1063726968 158 ----MPSPSWRL 165
Cdd:cd17366   165 teaqMLDWGWRI 176
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 23-132 2.35e-03

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 41.02  E-value: 2.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  23 ATIAGAVLYIKKEFNleSNPSVEGLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLG 102
Cdd:cd17323    16 SIYSPALPQIAEDFH--VSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIIL 93

                          90       100       110
                  ....*....|....*....|....*....|
gi 1063726968 103 RLLDGFGVGLVVTLVPIYISETAPPEIRGL 132
Cdd:cd17323    94 RFLQGFFGSSPLAIGAGTIADLFTPEERGK 123
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
 46-112 2.43e-03

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 40.70  E-value: 2.43e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063726968  46 GLIVAMSLIGATLITTCSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGVGL 112
Cdd:cd17393    37 GLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGA 103
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
502-671 2.61e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 40.73  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 502 KGSIWHDLHDPGVKRALVVGVGLQIlqqfsGINGVLYYTPQILEQ------AGVGILLSNMGissssasllisalttFVM 575
Cdd:COG2814   197 RGSLRELLRRPRLLLLLLLAFLLGF-----GFFALFTYLPLYLQEvlglsaSAAGLLLALFG---------------LGG 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 576 LPAIAVAMRLMDLSGRRTLLLTTIPILIASLLVLVISNlvhmnsivHAVLSTVSVVLyFCFFVMGFGPAPNILCSEIFPT 655
Cdd:COG2814   257 VLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG--------SLWLLLLALFL-LGFGFGLLFPLLQALVAELAPP 327

                         170
                  ....*....|....*.
gi 1063726968 656 RVRGICIAICALTFWI 671
Cdd:COG2814   328 EARGRASGLYNSAFFL 343
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
 64-174 2.73e-03

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 40.58  E-value: 2.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  64 GGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGF---GVGLVVTLVPIyisETAPPEIRGLLNTLPQFT 140
Cdd:cd17373    46 GCIADRFGRRPVLLFSLILILIFGLTVALAVSVTMFSTLRFLEGFclaGIILTLYLLRL---ELCDPGKRLMITMVASLV 122

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1063726968 141 GSGGMFLsycmVFGMSLMpSPSWRLMLGVLFIPS 174
Cdd:cd17373   123 AVAGQFL----MPGLAAL-CRDWRVLQALIICPF 151
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 573-736 3.20e-03

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 40.18  E-value: 3.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 573 FVMLPAIAVAM-RLMDLSGRRtlllttiPILIASLLVLVISNLVhmnsivhAVLSTVSVVLYFCFFVMGFG-----PAPN 646
Cdd:COG0477    59 LLGRAIGLLLFgRLGDRYGRK-------RVLLIGLLLFGLASLL-------CGLAPSPELLIAARALQGIGagglmPGAL 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 647 ILCSEIFPTRVRGICIAICALTFWICDIIVTYSLPVLLKSIGLAGVFGMYAIVCCISWVFVFiKVPETKGMPLEVITEFF 726
Cdd:COG0477   125 ALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRL-RLPESRGLLLALLALAL 203

                         170
                  ....*....|
gi 1063726968 727 SVGARQAEAA 736
Cdd:COG0477   204 AALLLAALAL 213
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 32-158 5.73e-03

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 39.87  E-value: 5.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  32 IKKEFNLESNPSVEGLIVAMSLIGATLITTcsgGVADWLGRRPMLILSSILYFVGSLVM-----------LWSPNVYVLL 100
Cdd:cd17358   266 IFDEAGSGLDPNTATIIIGVVQVVGTLVAT---LLVDRLGRRPLLLVSAIGMGIGLLALglyfylqehgaLLSSVSWLPL 342

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063726968 101 LGRLLD--GFGVGLVVtlVP-IYISETAPPEIRGLLNTLPQFTgsgGMFLSYCMVFGMSLM 158
Cdd:cd17358   343 VGLVIYiiSFSIGLGP--LPwVIMSEIFPAKIKGLAGSLVTLV---NWLFAFIVTKTFPFL 398
PRK15075 PRK15075
tricarballylate/proton symporter TcuC;
51-131 6.08e-03

tricarballylate/proton symporter TcuC;


Pssm-ID: 237902 [Multi-domain]  Cd Length: 434  Bit Score: 39.54  E-value: 6.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  51 MSLIGATLIttcsGGVADWLGRRPMLILSSILYFVGSLVM----------LWSPnvYVLLLGRLLDGFGVGLVVTLVPIY 120
Cdd:PRK15075   68 MRPLGAIVL----GAYIDRVGRRKGLIVTLSIMASGTLLIafvpgyatigLAAP--LLVLLGRLLQGFSAGVELGGVSVY 141

                          90
                  ....*....|.
gi 1063726968 121 ISETAPPEIRG 131
Cdd:PRK15075  142 LAEIATPGRKG 152
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 68-154 8.06e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 39.12  E-value: 8.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  68 DWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDgfGVGLVVTLVPIYISETAPPEIRGLLNTLpqFTGSGGMFL 147
Cdd:cd17472    57 DRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQ--GSGAISSVVMALLADLTREENRTKAMAL--IGASIGIAF 132


                  ....*..
gi 1063726968 148 SYCMVFG 154
Cdd:cd17472   133 AISMVLG 139
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
601-709 9.34e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 39.09  E-value: 9.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968 601 ILIASLLVLVISNLVHMNSIVHAVLSTVSVVLYFCFFVMGFGPAPNiLCSEIFPTRVRGICIAICALTFWICDIIVTYSL 680
Cdd:COG2223   273 VLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFA-LVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLF 351

                          90       100       110
                  ....*....|....*....|....*....|
gi 1063726968 681 PVLLKSIG-LAGVFGMYAIVCCISWVFVFI 709
Cdd:COG2223   352 GALLDATGsYTAAFLVFAVLALVALVLTLL 381
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 41-173 9.81e-03

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 38.81  E-value: 9.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726968  41 NPSVEGLIVAMSLIGATLittcSGGVADWLGRRPMLILSSILYFVGSLVMLWSPNVYVLLLGRLLDGFGVGLVVTLVPIY 120
Cdd:cd17374    37 KSVAQSIFMAGLLVGALI----FGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLIL 112

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063726968 121 ISETAPPEIRGLlntlpqftgsGGMFLSYCMVFGMSLMPS-----PSWRLMLGVLFIP 173
Cdd:cd17374   113 GTEWTTPRHRAL----------AITLTSCFFSIGQMLLAGlayaiRDWRLLQLVVSVP 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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