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Conserved domains on  [gi|1063725605|ref|NP_001328315|]
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S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [Arabidopsis thaliana]

Protein Classification

METTL5 family protein( domain architecture ID 10006292)

METTL5 family protein similar to Homo sapiens methyltransferase-like protein 5 that is a catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
4-204 1.14e-66

Predicted RNA methylase [General function prediction only];


:

Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 203.21  E-value: 1.14e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725605   4 KQLEGLLGDLEQFSNPKVEFEQYPTGPHIASRMLFTAEnSYGDITDKVVADFGCGCGTLSAAAALLDAASVIGFDIDPES 83
Cdd:COG2263     2 RELEIILEKLPGFSNPKVELEQYPTPAELAAELLHLAY-LRGDIEGKTVLDLGCGTGMLAIGAALLGAKKVVGVDIDPEA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725605  84 LETATLNAEELEVEIDFVQCDITKLELKGLiVDTVVMNPPFGTRKKGADMEFLSAAMKVAsKAVYSLHKTSTREHIKRAA 163
Cdd:COG2263    81 LEIARENAERLGVRVDFIRADVTRIPLGGS-VDTVVMNPPFGAQRRHADRPFLEKALEIA-AVIYSIHNAGSLDFVERFA 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1063725605 164 lRDfNAKSAEVICELRYDLPKLYKFHKRKEVDIAVDLWRFE 204
Cdd:COG2263   159 -AD-RGGEITHVFRAEFPIPRTFEFHRKRRRRIEVEVYRIE 197
 
Name Accession Description Interval E-value
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
4-204 1.14e-66

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 203.21  E-value: 1.14e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725605   4 KQLEGLLGDLEQFSNPKVEFEQYPTGPHIASRMLFTAEnSYGDITDKVVADFGCGCGTLSAAAALLDAASVIGFDIDPES 83
Cdd:COG2263     2 RELEIILEKLPGFSNPKVELEQYPTPAELAAELLHLAY-LRGDIEGKTVLDLGCGTGMLAIGAALLGAKKVVGVDIDPEA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725605  84 LETATLNAEELEVEIDFVQCDITKLELKGLiVDTVVMNPPFGTRKKGADMEFLSAAMKVAsKAVYSLHKTSTREHIKRAA 163
Cdd:COG2263    81 LEIARENAERLGVRVDFIRADVTRIPLGGS-VDTVVMNPPFGAQRRHADRPFLEKALEIA-AVIYSIHNAGSLDFVERFA 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1063725605 164 lRDfNAKSAEVICELRYDLPKLYKFHKRKEVDIAVDLWRFE 204
Cdd:COG2263   159 -AD-RGGEITHVFRAEFPIPRTFEFHRKRRRRIEVEVYRIE 197
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 52-121 3.01e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 57.57  E-value: 3.01e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725605  52 VADFGCGCGTLSAAAALLDAASVIGFDIDPESLETATLNAEELEVEIDFVQCDITKLELKGLIVDTVVMN 121
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDLPFPDGSFDLVVSS 70
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 52-124 1.06e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 51.28  E-value: 1.06e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063725605  52 VADFGCGCGTLSAAAALLDAASVIGFDIDPESLETA-TLNAEELEVEIDFVQCDITKL-ELKGLIVDTVVMNPPF 124
Cdd:cd02440     2 VLDLGCGTGALALALASGPGARVTGVDISPVALELArKAAAALLADNVEVLKGDAEELpPEADESFDVIISDPPL 76
rlmL PRK11783
bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2)) ...
 75-127 6.15e-07

bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL;


Pssm-ID: 236981 [Multi-domain]  Cd Length: 702  Bit Score: 49.03  E-value: 6.15e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063725605  75 IGFDIDPESLETATLNAEELEVE--IDFVQCDITKLE--LKGLIVDTVVMNPPFGTR 127
Cdd:PRK11783  260 YGSDIDPRVIQAARKNARRAGVAelITFEVKDVADLKnpLPKGPTGLVISNPPYGER 316
 
Name Accession Description Interval E-value
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
4-204 1.14e-66

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 203.21  E-value: 1.14e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725605   4 KQLEGLLGDLEQFSNPKVEFEQYPTGPHIASRMLFTAEnSYGDITDKVVADFGCGCGTLSAAAALLDAASVIGFDIDPES 83
Cdd:COG2263     2 RELEIILEKLPGFSNPKVELEQYPTPAELAAELLHLAY-LRGDIEGKTVLDLGCGTGMLAIGAALLGAKKVVGVDIDPEA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725605  84 LETATLNAEELEVEIDFVQCDITKLELKGLiVDTVVMNPPFGTRKKGADMEFLSAAMKVAsKAVYSLHKTSTREHIKRAA 163
Cdd:COG2263    81 LEIARENAERLGVRVDFIRADVTRIPLGGS-VDTVVMNPPFGAQRRHADRPFLEKALEIA-AVIYSIHNAGSLDFVERFA 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1063725605 164 lRDfNAKSAEVICELRYDLPKLYKFHKRKEVDIAVDLWRFE 204
Cdd:COG2263   159 -AD-RGGEITHVFRAEFPIPRTFEFHRKRRRRIEVEVYRIE 197
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 52-121 3.01e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 57.57  E-value: 3.01e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725605  52 VADFGCGCGTLSAAAALLDAASVIGFDIDPESLETATLNAEELEVEIDFVQCDITKLELKGLIVDTVVMN 121
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDLPFPDGSFDLVVSS 70
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 74-145 9.74e-10

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 55.44  E-value: 9.74e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063725605  74 VIGFDIDPESLETATLNAEE--LEVEIDFVQCDITKLELKGLIVDTVVMNPPFGTR--KKGADMEFLSAAMKVASK 145
Cdd:pfam01170  66 LYGSDIDRRMVQGARLNAENagVGDLIEFVQADAADLPLLEGSVDVIVTNPPYGIRlgSKGALEALYPEFLREAKR 141
RlmL COG0116
23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA ...
 74-127 4.80e-09

23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA G2445 N2-methylase RlmL is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 439886 [Multi-domain]  Cd Length: 369  Bit Score: 55.11  E-value: 4.80e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1063725605  74 VIGFDIDPESLETATLNAEELEVE--IDFVQCDITKLELKGlIVDTVVMNPPFGTR 127
Cdd:COG0116   253 IFGSDIDPRAIEAARENAERAGVAdlIEFEQADFRDLEPPA-EPGLIITNPPYGER 307
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 52-124 1.06e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 51.28  E-value: 1.06e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063725605  52 VADFGCGCGTLSAAAALLDAASVIGFDIDPESLETA-TLNAEELEVEIDFVQCDITKL-ELKGLIVDTVVMNPPF 124
Cdd:cd02440     2 VLDLGCGTGALALALASGPGARVTGVDISPVALELArKAAAALLADNVEVLKGDAEELpPEADESFDVIISDPPL 76
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 74-165 2.51e-08

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 51.49  E-value: 2.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725605  74 VIGFDIDPESLETATLNAEELEVE-IDFVQCDITKLELKGLIVDTVVMNPPFG--TRKKGADME-----FLSAAMKVA-- 143
Cdd:COG1041    51 VIGSDIDPKMVEGARENLEHYGYEdADVIRGDARDLPLADESVDAIVTDPPYGrsSKISGEELLelyekALEEAARVLkp 130

                          90       100
                  ....*....|....*....|...
gi 1063725605 144 -SKAVYSLHKTStREHIKRAALR 165
Cdd:COG1041   131 gGRVVIVTPRDI-DELLEEAGFK 152
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 52-121 1.64e-07

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 49.53  E-value: 1.64e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063725605  52 VADFGCGCGTLSAAAALLDAASVIGFDIDPESLETATLNAEELEVE-IDFVQCDITKL-ELKGLIVDTVVMN 121
Cdd:COG0500    30 VLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAGLGnVEFLVADLAELdPLPAESFDLVVAF 101
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 49-121 1.65e-07

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 48.48  E-value: 1.65e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063725605  49 DKVVADFGCGCGtLSAAAALLDAASVIGFDIDPESLETATLNAEELevEIDFVQCDITKLELKGLIVDTVVMN 121
Cdd:COG2227    25 GGRVLDVGCGTG-RLALALARRGADVTGVDISPEALEIARERAAEL--NVDFVQGDLEDLPLEDGSFDLVICS 94
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 52-124 3.54e-07

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 48.65  E-value: 3.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725605  52 VADFGCGCGtlsaaaalldaasVIG--------------FDIDPESLETATLNAEELEVE-IDFVQCDITKlELKGLIVD 116
Cdd:COG2813    53 VLDLGCGYG-------------VIGlalakrnpearvtlVDVNARAVELARANAAANGLEnVEVLWSDGLS-GVPDGSFD 118


                  ....*...
gi 1063725605 117 TVVMNPPF 124
Cdd:COG2813   119 LILSNPPF 126
rlmL PRK11783
bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2)) ...
 75-127 6.15e-07

bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL;


Pssm-ID: 236981 [Multi-domain]  Cd Length: 702  Bit Score: 49.03  E-value: 6.15e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063725605  75 IGFDIDPESLETATLNAEELEVE--IDFVQCDITKLE--LKGLIVDTVVMNPPFGTR 127
Cdd:PRK11783  260 YGSDIDPRVIQAARKNARRAGVAelITFEVKDVADLKnpLPKGPTGLVISNPPYGER 316
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 49-121 9.92e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 46.53  E-value: 9.92e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063725605  49 DKVVADFGCGCGTLSAAAALLDAAsVIGFDIDPESLETATLNAEELEVEIDFVQCDITKLELKGLIVDTVVMN 121
Cdd:COG2226    23 GARVLDLGCGTGRLALALAERGAR-VTGVDISPEMLELARERAAEAGLNVEFVVGDAEDLPFPDGSFDLVISS 94
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 21-148 1.04e-06

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 48.25  E-value: 1.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725605  21 VEFEQYPTG-----PHIASRMLFTAENSYGDITDKVVADFGCGCGT------LSAAAalldaasVIGFDIDPESLETATL 89
Cdd:COG2265   201 LTFRISPGSffqvnPEQAEALYAAALEWLDLTGGERVLDLYCGVGTfalplaRRAKK-------VIGVEIVPEAVEDARE 273

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063725605  90 NAEELEVE-IDFVQCDITKL---ELKGLIVDTVVMNPPfgtRkKGADMEFLS--AAMKVAsKAVY 148
Cdd:COG2265   274 NARLNGLKnVEFVAGDLEEVlpeLLWGGRPDVVVLDPP---R-AGAGPEVLEalAALGPR-RIVY 333
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 52-124 1.14e-05

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 44.75  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725605  52 VADFGCGCG---------TLSAAaalldaasVIGFDIDPESLETATLNAEE--LEVEIDFVQCDITKL--ELKGLIVDTV 118
Cdd:COG4123    41 VLDLGTGTGvialmlaqrSPGAR--------ITGVEIQPEAAELARRNVALngLEDRITVIHGDLKEFaaELPPGSFDLV 112


                  ....*.
gi 1063725605 119 VMNPPF 124
Cdd:COG4123   113 VSNPPY 118
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 46-112 2.21e-05

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 43.72  E-value: 2.21e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063725605  46 DITDKVVADFGCGCGTLSAAAALLDAASVIGFDIDPESLETATLNAEELEVEIDFVQCDITKLELKG 112
Cdd:COG3897    68 EVAGKRVLELGCGLGLVGIAAAKAGAADVTATDYDPEALAALRLNAALNGVAITTRLGDWRDPPAAG 134
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 47-124 2.78e-05

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 42.96  E-value: 2.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725605  47 ITDKVVADFGCGCGT-LSAAAALLDAASVIGFDIDPESLETATLNAEELEVE-IDFVQCDITKlELKGLIVDTVVMNPPF 124
Cdd:pfam05175  30 DLSGKVLDLGCGAGVlGAALAKESPDAELTMVDINARALESARENLAANGLEnGEVVASDVYS-GVEDGKFDLIISNPPF 108
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 74-123 3.89e-05

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 43.21  E-value: 3.89e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1063725605  74 VIGFDIDPESLETATLNAEELEVE--IDFVQCDITKlELKGLI-VDTVVMNPP 123
Cdd:COG2890   139 VTAVDISPDALAVARRNAERLGLEdrVRFLQGDLFE-PLPGDGrFDLIVSNPP 190
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 49-121 7.25e-05

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 41.25  E-value: 7.25e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063725605  49 DKVVADFGCGCG--TLSAAAALLDAASVIGFDIDPESLETATLNAEELEVE-IDFVQCDITKLE--LKGLIVDTVVMN 121
Cdd:pfam13847   4 GMRVLDLGCGTGhlSFELAEELGPNAEVVGIDISEEAIEKARENAQKLGFDnVEFEQGDIEELPelLEDDKFDVVISN 81
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 74-123 1.52e-04

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 41.30  E-value: 1.52e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063725605  74 VIGFDIDPESLETATLNAE-ELEVEIDFVQCDITKlELKGLIVDTVVMNPP 123
Cdd:PRK09328  135 VTAVDISPEALAVARRNAKhGLGARVEFLQGDWFE-PLPGGRFDLIVSNPP 184
Methyltransf_15 pfam09445
RNA cap guanine-N2 methyltransferase; RNA cap guanine-N2 methyltransferases such as ...
 74-156 6.52e-04

RNA cap guanine-N2 methyltransferase; RNA cap guanine-N2 methyltransferases such as Schizosaccharomyces pombe Tgs1 and Giardia lamblia Tgs2 catalyze methylation of the exocyclic N2 amine of 7-methylguanosine.


Pssm-ID: 370496  Cd Length: 165  Bit Score: 38.85  E-value: 6.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725605  74 VIGFDIDPESLETATLNAEELEVE--IDFVQCD----ITKLELKGLIVDTVVMNPPFG----TRKKGADMEFlsaamKVA 143
Cdd:pfam09445  25 VISIDINLEHLACAQHNAEVYGVSdrIWLIHGDwfelLAKLKFEKIKYDCVFASPPWGgpsyKKQNVYDLEN-----KLQ 99

                          90
                  ....*....|...
gi 1063725605 144 SKAVYSLHKTSTR 156
Cdd:pfam09445 100 PYGLSQLLKEFTK 112
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 54-121 1.15e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 36.87  E-value: 1.15e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063725605  54 DFGCGCGtLSAAAALLDAASVIGFDIDPESLETATLNAEelEVEIDFVQCDITKLELKGLIVDTVVMN 121
Cdd:pfam08241   2 DVGCGTG-LLTELLARLGARVTGVDISPEMLELAREKAP--REGLTFVVGDAEDLPFPDNSFDLVLSS 66
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 12-112 2.31e-03

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 37.22  E-value: 2.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725605  12 DLEQFSNPKVEfeqyptgpHIASRMLFTAensyGDitdkVVADFGCGCGTLSAAAALLDAASVIGFDIDPESLETATLNA 91
Cdd:COG2230    31 TLEEAQEAKLD--------LILRKLGLKP----GM----RVLDIGCGWGGLALYLARRYGVRVTGVTLSPEQLEYARERA 94

                          90       100
                  ....*....|....*....|...
gi 1063725605  92 EELEVE--IDFVQCDITKLELKG 112
Cdd:COG2230    95 AEAGLAdrVEVRLADYRDLPADG 117
PRK14967 PRK14967
putative methyltransferase; Provisional
 52-124 4.65e-03

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 36.95  E-value: 4.65e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063725605  52 VADFGCGCGTLSAAAALLDAASVIGFDIDPESLETATLNAEELEVEIDFVQCDITKlELKGLIVDTVVMNPPF 124
Cdd:PRK14967   40 VLDLCTGSGALAVAAAAAGAGSVTAVDISRRAVRSARLNALLAGVDVDVRRGDWAR-AVEFRPFDVVVSNPPY 111
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
52-121 4.75e-03

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 35.18  E-value: 4.75e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063725605  52 VADFGCGCGTLSAA-AALLDAASVIGFDIDPESLETATLNAEELEveidFVQCDITKLELKGLiVDTVVMN 121
Cdd:COG4106     5 VLDLGCGTGRLTALlAERFPGARVTGVDLSPEMLARARARLPNVR----FVVADLRDLDPPEP-FDLVVSN 70
PRK14968 PRK14968
putative methyltransferase; Provisional
 49-124 7.14e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 36.03  E-value: 7.14e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063725605  49 DKVVADFGCGCGtLSAAAALLDAASVIGFDIDPESLETATLNAEELEVE---IDFVQCDITKlELKGLIVDTVVMNPPF 124
Cdd:PRK14968   24 GDRVLEVGTGSG-IVAIVAAKNGKKVVGVDINPYAVECAKCNAKLNNIRnngVEVIRSDLFE-PFRGDKFDVILFNPPY 100
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
21-121 7.69e-03

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 35.74  E-value: 7.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725605  21 VEFEQYPTGPHIASRMLftaeNSYGDITDKVVADFGCGCGTlSAAAALLDAASVIGFDIDPESLETatlnAEELEVEIDF 100
Cdd:COG4976    23 VEDLGYEAPALLAEELL----ARLPPGPFGRVLDLGCGTGL-LGEALRPRGYRLTGVDLSEEMLAK----AREKGVYDRL 93

                          90       100
                  ....*....|....*....|.
gi 1063725605 101 VQCDITKLELKGLIVDTVVMN 121
Cdd:COG4976    94 LVADLADLAEPDGRFDLIVAA 114
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
49-121 9.40e-03

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 35.92  E-value: 9.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725605  49 DKVVADFGCG----------CGtlsaaaalldAASVIGFDIDPESLETATLNAE--ELEVEIDFVQCDItkleLKGLIVD 116
Cdd:COG2264   149 GKTVLDVGCGsgilaiaaakLG----------AKRVLAVDIDPVAVEAARENAElnGVEDRIEVVLGDL----LEDGPYD 214


                  ....*
gi 1063725605 117 TVVMN 121
Cdd:COG2264   215 LVVAN 219
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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