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Conserved domains on  [gi|1063725438|ref|NP_001328776|]
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P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

Protein Classification

ATP-binding protein( domain architecture ID 11440662)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain may function as an ATPase

Gene Ontology:  GO:0005524|GO:0016887

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
487-762 8.97e-85

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 273.42  E-value: 8.97e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 487 PPKAPVHEVAPDNEFEKRIRPEVIPANEIGVTFADIGSLDETKESLQELVMLPLRRPDLFKGGLLKPCRGILLFGPPGTG 566
Cdd:COG1222    45 APALLLNDANLTQKRLGTPRGTAVPAESPDVTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTG 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 567 KTMMAKAIANEAGASFINVSMSTITSKWFGEDEKNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRVGEHEAMRKIKNEFM 646
Cdd:COG1222   125 KTLLAKAVAGELGAPFIRVRGSELVSKYIGEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSGEVQRTVNQLL 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 647 THWDGLMSNagDRILVLAATNRPFDLDEAIIR--RFERRIMVGLPSVESREKILRTLLSKEKT-ENLDFQELAQMTDGYS 723
Cdd:COG1222   205 AELDGFESR--GDVLIIAATNRPDLLDPALLRpgRFDRVIEVPLPDEEAREEILKIHLRDMPLaDDVDLDKLAKLTEGFS 282
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1063725438 724 GSDLKNFCTTAAYRPVRE---LIKQECLKD--QERRKREEAEKN 762
Cdd:COG1222   283 GADLKAIVTEAGMFAIREgrdTVTMEDLEKaiEKVKKKTETATN 326
 
Name Accession Description Interval E-value
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
487-762 8.97e-85

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 273.42  E-value: 8.97e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 487 PPKAPVHEVAPDNEFEKRIRPEVIPANEIGVTFADIGSLDETKESLQELVMLPLRRPDLFKGGLLKPCRGILLFGPPGTG 566
Cdd:COG1222    45 APALLLNDANLTQKRLGTPRGTAVPAESPDVTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTG 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 567 KTMMAKAIANEAGASFINVSMSTITSKWFGEDEKNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRVGEHEAMRKIKNEFM 646
Cdd:COG1222   125 KTLLAKAVAGELGAPFIRVRGSELVSKYIGEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSGEVQRTVNQLL 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 647 THWDGLMSNagDRILVLAATNRPFDLDEAIIR--RFERRIMVGLPSVESREKILRTLLSKEKT-ENLDFQELAQMTDGYS 723
Cdd:COG1222   205 AELDGFESR--GDVLIIAATNRPDLLDPALLRpgRFDRVIEVPLPDEEAREEILKIHLRDMPLaDDVDLDKLAKLTEGFS 282
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1063725438 724 GSDLKNFCTTAAYRPVRE---LIKQECLKD--QERRKREEAEKN 762
Cdd:COG1222   283 GADLKAIVTEAGMFAIREgrdTVTMEDLEKaiEKVKKKTETATN 326
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
521-686 3.93e-83

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 262.75  E-value: 3.93e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 521 DIGSLDETKESLQELVMLPLRRPDLF-KGGLLKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDE 599
Cdd:cd19520     1 DIGGLDEVITELKELVILPLQRPELFdNSRLLQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 600 KNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRvGEHEAMRKIKNEFMTHWDGLMSNAGDRILVLAATNRPFDLDEAIIRR 679
Cdd:cd19520    81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQRSS-TDHEATAMMKAEFMSLWDGLSTDGNCRVIVMGATNRPQDLDEAILRR 159

                  ....*..
gi 1063725438 680 FERRIMV 686
Cdd:cd19520   160 MPKRFHI 166
cell_div_CdvC NF041006
cell division protein CdvC;
471-754 3.88e-71

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 238.48  E-value: 3.88e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 471 NESDTSIPAAKNECPLPPKAPVHEVAPDNEFEKRIRPEVipaneigvTFADIGSLDETKESLQELVMLPLRRPDLFKGGL 550
Cdd:NF041006   62 NEYKKRIEVLEELVPAEPAGPDVEKESDEELVVKEKPKV--------TFSDIVGLEDVKEALKEAIVYPSKRPDLFPLGW 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 551 lkPcRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDEKNVRALFTLAAKVS-----PTIIFVDEVDSM 625
Cdd:NF041006  134 --P-RGILLYGPPGCGKTMLAAAVANEIDSEFIHVDAASIMSKWLGEAEKNVAKIFKKAREKSkeegkPAIIFIDEIDAL 210
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 626 LGqrTRVGEHEAMRKIKNEFMTHWDGLM-SNAGDRILVLAATNRPFDLDEAIIRRFERRIMVGLPSVESREKILRTLLSK 704
Cdd:NF041006  211 LG--VYSSEVGGEVRVRNQFLKEMDGLQdKSENYHVYVIGATNKPWRLDEPFLRRFQKRIYIPLPDREQRLELLKYYTSK 288
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063725438 705 EKTEN-LDFQELAQMTDGYSGSDLKNFCTTAAYRPVRELIKQeclKDQERR 754
Cdd:NF041006  289 IKLENdVDLDELAEMTEGYTASDIRDIVQAAHMRVVKEMFEK---GLGEPR 336
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
498-741 4.22e-59

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 206.22  E-value: 4.22e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 498 DNEFEKRIRP-EVIPANEigVTFADIGSLDETKESLQELVMLPLRRPDLFKGGLLKPCRGILLFGPPGTGKTMMAKAIAN 576
Cdd:PRK03992  110 PSEKDPRVQAmEVIESPN--VTYEDIGGLEEQIREVREAVELPLKKPELFEEVGIEPPKGVLLYGPPGTGKTLLAKAVAH 187
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 577 EAGASFINVSMSTITSKWFGEDEKNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRV---GEHEAMRKIKnEFMTHWDGLm 653
Cdd:PRK03992  188 ETNATFIRVVGSELVQKFIGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRTDSgtsGDREVQRTLM-QLLAEMDGF- 265
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 654 SNAGDrILVLAATNRPFDLDEAIIR--RFERRIMVGLPSVESREKILRTLLSKEKT-ENLDFQELAQMTDGYSGSDLKNF 730
Cdd:PRK03992  266 DPRGN-VKIIAATNRIDILDPAILRpgRFDRIIEVPLPDEEGRLEILKIHTRKMNLaDDVDLEELAELTEGASGADLKAI 344
                         250
                  ....*....|.
gi 1063725438 731 CTTAAYRPVRE 741
Cdd:PRK03992  345 CTEAGMFAIRD 355
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
517-791 5.02e-55

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 202.83  E-value: 5.02e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 517 VTFADIGSLDETKESLQELVMLPLRRPDLFKGGLLKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFG 596
Cdd:TIGR01243 450 VRWSDIGGLEEVKQELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVG 529
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 597 EDEKNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRVGEHEAMRKIKNEFMTHWDGLMSNAGdrILVLAATNRPFDLDEAI 676
Cdd:TIGR01243 530 ESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDTSVTDRIVNQLLTEMDGIQELSN--VVVIAATNRPDILDPAL 607
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 677 IR--RFERRIMVGLPSVESREKILRT-LLSKEKTENLDFQELAQMTDGYSGSDLKNFCTTAAYRPVRELIKQeclkdQER 753
Cdd:TIGR01243 608 LRpgRFDRLILVPPPDEEARKEIFKIhTRSMPLAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIGS-----PAK 682
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1063725438 754 RKREEAEKNSEEGSEAKEEVSEERGITLRP-LSMEDMKV 791
Cdd:TIGR01243 683 EKLEVGEEEFLKDLKVEMRHFLEALKKVKPsVSKEDMLR 721
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
557-688 2.45e-50

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 172.78  E-value: 2.45e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 557 ILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDEKNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRVGEHE 636
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1063725438 637 AMRkIKNEFMTHWDGlMSNAGDRILVLAATNRPFDLDEAIIRRFERRIMVGL 688
Cdd:pfam00004  81 SRR-VVNQLLTELDG-FTSSNSKVIVIAATNRPDKLDPALLGRFDRIIEFPL 130
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
555-689 1.84e-18

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 82.81  E-value: 1.84e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438  555 RGILLFGPPGTGKTMMAKAIANEA---GASFINVSMSTITS--------------KWFGEDEKNVRALFTLAAKVSPTII 617
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELgppGGGVIYIDGEDILEevldqllliivggkKASGSGELRLRLALALARKLKPDVL 82
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063725438  618 FVDEVDSMLGQRTRVGEHEAMRKIKnefmthwdGLMSNAGDRILVLAATNRPFDLDEAIIR-RFERRIMVGLP 689
Cdd:smart00382  83 ILDEITSLLDAEQEALLLLLEELRL--------LLLLKSEKNLTVILTTNDEKDLGPALLRrRFDRRIVLLLI 147
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
544-578 1.10e-03

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 41.30  E-value: 1.10e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1063725438 544 DLFKGGLLKPCRGILLFGPPGTGKTMMAKAIANEA 578
Cdd:NF038214   80 ELATLDFIERAENVLLLGPPGTGKTHLAIALGYAA 114
 
Name Accession Description Interval E-value
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
487-762 8.97e-85

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 273.42  E-value: 8.97e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 487 PPKAPVHEVAPDNEFEKRIRPEVIPANEIGVTFADIGSLDETKESLQELVMLPLRRPDLFKGGLLKPCRGILLFGPPGTG 566
Cdd:COG1222    45 APALLLNDANLTQKRLGTPRGTAVPAESPDVTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTG 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 567 KTMMAKAIANEAGASFINVSMSTITSKWFGEDEKNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRVGEHEAMRKIKNEFM 646
Cdd:COG1222   125 KTLLAKAVAGELGAPFIRVRGSELVSKYIGEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSGEVQRTVNQLL 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 647 THWDGLMSNagDRILVLAATNRPFDLDEAIIR--RFERRIMVGLPSVESREKILRTLLSKEKT-ENLDFQELAQMTDGYS 723
Cdd:COG1222   205 AELDGFESR--GDVLIIAATNRPDLLDPALLRpgRFDRVIEVPLPDEEAREEILKIHLRDMPLaDDVDLDKLAKLTEGFS 282
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1063725438 724 GSDLKNFCTTAAYRPVRE---LIKQECLKD--QERRKREEAEKN 762
Cdd:COG1222   283 GADLKAIVTEAGMFAIREgrdTVTMEDLEKaiEKVKKKTETATN 326
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
521-686 3.93e-83

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 262.75  E-value: 3.93e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 521 DIGSLDETKESLQELVMLPLRRPDLF-KGGLLKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDE 599
Cdd:cd19520     1 DIGGLDEVITELKELVILPLQRPELFdNSRLLQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 600 KNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRvGEHEAMRKIKNEFMTHWDGLMSNAGDRILVLAATNRPFDLDEAIIRR 679
Cdd:cd19520    81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQRSS-TDHEATAMMKAEFMSLWDGLSTDGNCRVIVMGATNRPQDLDEAILRR 159

                  ....*..
gi 1063725438 680 FERRIMV 686
Cdd:cd19520   160 MPKRFHI 166
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
522-686 6.02e-75

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 241.10  E-value: 6.02e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 522 IGSLDETKESLQELVMLPLRRPDLFKGgLLKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDEKN 601
Cdd:cd19509     1 IAGLDDAKEALKEAVILPSLRPDLFPG-LRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 602 VRALFTLAAKVSPTIIFVDEVDSMLGQRTRvGEHEAMRKIKNEFMTHWDGLMSNAGDRILVLAATNRPFDLDEAIIRRFE 681
Cdd:cd19509    80 VRALFALARELQPSIIFIDEIDSLLSERGS-GEHEASRRVKTEFLVQMDGVLNKPEDRVLVLGATNRPWELDEAFLRRFE 158

                  ....*
gi 1063725438 682 RRIMV 686
Cdd:cd19509   159 KRIYI 163
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
486-741 1.41e-72

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 243.28  E-value: 1.41e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 486 LPPKAPVHEVAPDNEFEKRIRPEVIPANEIGVTFADIGSLDETKESLQELVMLPLRRPDLFKGGLLKPCRGILLFGPPGT 565
Cdd:COG0464   123 RESAEALALAAPLVTYEDIGGLEEELLELREAILDDLGGLEEVKEELRELVALPLKRPELREEYGLPPPRGLLLYGPPGT 202
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 566 GKTMMAKAIANEAGASFINVSMSTITSKWFGEDEKNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRVGEHeAMRKIKNEF 645
Cdd:COG0464   203 GKTLLARALAGELGLPLIEVDLSDLVSKYVGETEKNLREVFDKARGLAPCVLFIDEADALAGKRGEVGDG-VGRRVVNTL 281
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 646 MTHwdglMSNAGDRILVLAATNRPFDLDEAIIRRFERRIMVGLPSVESREKILRTLLSK-EKTENLDFQELAQMTDGYSG 724
Cdd:COG0464   282 LTE----MEELRSDVVVIAATNRPDLLDPALLRRFDEIIFFPLPDAEERLEIFRIHLRKrPLDEDVDLEELAEATEGLSG 357
                         250
                  ....*....|....*..
gi 1063725438 725 SDLKNFCTTAAYRPVRE 741
Cdd:COG0464   358 ADIRNVVRRAALQALRL 374
cell_div_CdvC NF041006
cell division protein CdvC;
471-754 3.88e-71

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 238.48  E-value: 3.88e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 471 NESDTSIPAAKNECPLPPKAPVHEVAPDNEFEKRIRPEVipaneigvTFADIGSLDETKESLQELVMLPLRRPDLFKGGL 550
Cdd:NF041006   62 NEYKKRIEVLEELVPAEPAGPDVEKESDEELVVKEKPKV--------TFSDIVGLEDVKEALKEAIVYPSKRPDLFPLGW 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 551 lkPcRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDEKNVRALFTLAAKVS-----PTIIFVDEVDSM 625
Cdd:NF041006  134 --P-RGILLYGPPGCGKTMLAAAVANEIDSEFIHVDAASIMSKWLGEAEKNVAKIFKKAREKSkeegkPAIIFIDEIDAL 210
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 626 LGqrTRVGEHEAMRKIKNEFMTHWDGLM-SNAGDRILVLAATNRPFDLDEAIIRRFERRIMVGLPSVESREKILRTLLSK 704
Cdd:NF041006  211 LG--VYSSEVGGEVRVRNQFLKEMDGLQdKSENYHVYVIGATNKPWRLDEPFLRRFQKRIYIPLPDREQRLELLKYYTSK 288
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063725438 705 EKTEN-LDFQELAQMTDGYSGSDLKNFCTTAAYRPVRELIKQeclKDQERR 754
Cdd:NF041006  289 IKLENdVDLDELAEMTEGYTASDIRDIVQAAHMRVVKEMFEK---GLGEPR 336
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
521-686 2.15e-63

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 210.09  E-value: 2.15e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 521 DIGSLDETKESLQELVMLPLRRPDLFKGgLLKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDEK 600
Cdd:cd19524     1 DIAGQDLAKQALQEMVILPSLRPELFTG-LRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 601 NVRALFTLAAKVSPTIIFVDEVDSMLGQRtRVGEHEAMRKIKNEFMTHWDGLMSNAGDRILVLAATNRPFDLDEAIIRRF 680
Cdd:cd19524    80 LVRALFAVARELQPSIIFIDEVDSLLSER-SEGEHEASRRLKTEFLIEFDGVQSNGDDRVLVMGATNRPQELDDAVLRRF 158

                  ....*.
gi 1063725438 681 ERRIMV 686
Cdd:cd19524   159 TKRVYV 164
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
513-686 1.20e-60

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 203.30  E-value: 1.20e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 513 NEIGvtFADIGSLDETKESLQELVMLPLRRPDLFKGgLLKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITS 592
Cdd:cd19525    17 PPIN--WADIAGLEFAKKTIKEIVVWPMLRPDIFTG-LRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTS 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 593 KWFGEDEKNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRvGEHEAMRKIKNEFMTHWDGLMSNAGDRILVLAATNRPFDL 672
Cdd:cd19525    94 KWVGEGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGE-GEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEI 172
                         170
                  ....*....|....
gi 1063725438 673 DEAIIRRFERRIMV 686
Cdd:cd19525   173 DEAARRRLVKRLYI 186
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
498-741 4.22e-59

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 206.22  E-value: 4.22e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 498 DNEFEKRIRP-EVIPANEigVTFADIGSLDETKESLQELVMLPLRRPDLFKGGLLKPCRGILLFGPPGTGKTMMAKAIAN 576
Cdd:PRK03992  110 PSEKDPRVQAmEVIESPN--VTYEDIGGLEEQIREVREAVELPLKKPELFEEVGIEPPKGVLLYGPPGTGKTLLAKAVAH 187
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 577 EAGASFINVSMSTITSKWFGEDEKNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRV---GEHEAMRKIKnEFMTHWDGLm 653
Cdd:PRK03992  188 ETNATFIRVVGSELVQKFIGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRTDSgtsGDREVQRTLM-QLLAEMDGF- 265
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 654 SNAGDrILVLAATNRPFDLDEAIIR--RFERRIMVGLPSVESREKILRTLLSKEKT-ENLDFQELAQMTDGYSGSDLKNF 730
Cdd:PRK03992  266 DPRGN-VKIIAATNRIDILDPAILRpgRFDRIIEVPLPDEEGRLEILKIHTRKMNLaDDVDLEELAELTEGASGADLKAI 344
                         250
                  ....*....|.
gi 1063725438 731 CTTAAYRPVRE 741
Cdd:PRK03992  345 CTEAGMFAIRD 355
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
521-686 2.60e-57

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 193.66  E-value: 2.60e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 521 DIGSLDETKESLQELVMLPLRRPDLFKGgLLKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDEK 600
Cdd:cd19522     1 DIADLEEAKKLLEEAVVLPMWMPEFFKG-IRRPWKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESEK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 601 NVRALFTLAAKVSPTIIFVDEVDSMLGQRTRVGEHEAMRKIKNEFMTHWDGLMSNAGDR-----ILVLAATNRPFDLDEA 675
Cdd:cd19522    80 LVRLLFEMARFYAPTTIFIDEIDSICSRRGTSEEHEASRRVKSELLVQMDGVGGASENDdpskmVMVLAATNFPWDIDEA 159
                         170
                  ....*....|.
gi 1063725438 676 IIRRFERRIMV 686
Cdd:cd19522   160 LRRRLEKRIYI 170
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
517-686 8.32e-57

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 192.38  E-value: 8.32e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 517 VTFADIGSLDETKESLQELVMLPLRRPDLFKGGLlKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFG 596
Cdd:cd19521     4 VKWEDVAGLEGAKEALKEAVILPVKFPHLFTGNR-KPWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 597 EDEKNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRvGEHEAMRKIKNEFMTHWDGLmSNAGDRILVLAATNRPFDLDEAI 676
Cdd:cd19521    83 ESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRGE-GESEASRRIKTELLVQMNGV-GNDSQGVLVLGATNIPWQLDSAI 160
                         170
                  ....*....|
gi 1063725438 677 IRRFERRIMV 686
Cdd:cd19521   161 RRRFEKRIYI 170
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
517-791 5.02e-55

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 202.83  E-value: 5.02e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 517 VTFADIGSLDETKESLQELVMLPLRRPDLFKGGLLKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFG 596
Cdd:TIGR01243 450 VRWSDIGGLEEVKQELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVG 529
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 597 EDEKNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRVGEHEAMRKIKNEFMTHWDGLMSNAGdrILVLAATNRPFDLDEAI 676
Cdd:TIGR01243 530 ESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDTSVTDRIVNQLLTEMDGIQELSN--VVVIAATNRPDILDPAL 607
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 677 IR--RFERRIMVGLPSVESREKILRT-LLSKEKTENLDFQELAQMTDGYSGSDLKNFCTTAAYRPVRELIKQeclkdQER 753
Cdd:TIGR01243 608 LRpgRFDRLILVPPPDEEARKEIFKIhTRSMPLAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIGS-----PAK 682
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1063725438 754 RKREEAEKNSEEGSEAKEEVSEERGITLRP-LSMEDMKV 791
Cdd:TIGR01243 683 EKLEVGEEEFLKDLKVEMRHFLEALKKVKPsVSKEDMLR 721
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
488-790 3.24e-54

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 200.52  E-value: 3.24e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 488 PKAPVHeVAPDNEFEKRIRP--EVIPANEIGVTFADIGSLDETKESLQELVMLPLRRPDLFKGGLLKPCRGILLFGPPGT 565
Cdd:TIGR01243 145 PAGFVY-VTEATEVEIREKPvrEEIERKVPKVTYEDIGGLKEAKEKIREMVELPMKHPELFEHLGIEPPKGVLLYGPPGT 223
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 566 GKTMMAKAIANEAGASFINVSMSTITSKWFGEDEKNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRV-GEHEamRKIKNE 644
Cdd:TIGR01243 224 GKTLLAKAVANEAGAYFISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVtGEVE--KRVVAQ 301
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 645 FMTHWDGLMSNAgdRILVLAATNRPFDLDEAIIR--RFERRIMVGLPSVESREKILRT-LLSKEKTENLDFQELAQMTDG 721
Cdd:TIGR01243 302 LLTLMDGLKGRG--RVIVIGATNRPDALDPALRRpgRFDREIVIRVPDKRARKEILKVhTRNMPLAEDVDLDKLAEVTHG 379
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063725438 722 YSGSDLKNFCTTAAYRPVRELIKQeclkdqerrkreeaEKNSEEGSEAKEEVSEERGITLRPLsMEDMK 790
Cdd:TIGR01243 380 FVGADLAALAKEAAMAALRRFIRE--------------GKINFEAEEIPAEVLKELKVTMKDF-MEALK 433
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
528-686 5.78e-51

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 175.55  E-value: 5.78e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 528 TKESLQELVMLPLRRPDLFKGGLLKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDEKNVRALFT 607
Cdd:cd19511     1 VKRELKEAVEWPLKHPDAFKRLGIRPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 608 LAAKVSPTIIFVDEVDSMLGQRTRVGEHEAMRKIKNEFMTHWDGLmsNAGDRILVLAATNRPFDLDEAIIR--RFERRIM 685
Cdd:cd19511    81 KARQAAPCIIFFDEIDSLAPRRGQSDSSGVTDRVVSQLLTELDGI--ESLKGVVVIAATNRPDMIDPALLRpgRLDKLIY 158

                  .
gi 1063725438 686 V 686
Cdd:cd19511   159 V 159
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
557-688 2.45e-50

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 172.78  E-value: 2.45e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 557 ILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDEKNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRVGEHE 636
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1063725438 637 AMRkIKNEFMTHWDGlMSNAGDRILVLAATNRPFDLDEAIIRRFERRIMVGL 688
Cdd:pfam00004  81 SRR-VVNQLLTELDG-FTSSNSKVIVIAATNRPDKLDPALLGRFDRIIEFPL 130
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
521-684 6.93e-50

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 172.86  E-value: 6.93e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 521 DIGSLDETKESLQELVMLPLRRPDLFKGGLLKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDEK 600
Cdd:cd19503     1 DIGGLDEQIASLKELIELPLKYPELFRALGLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 601 NVRALFTLAAKVSPTIIFVDEVDSMLGQRTRVGeHEAMRKIKNEFMTHWDGlMSNAGdRILVLAATNRPFDLDEAIIR-- 678
Cdd:cd19503    81 NLREIFEEARSHAPSIIFIDEIDALAPKREEDQ-REVERRVVAQLLTLMDG-MSSRG-KVVVIAATNRPDAIDPALRRpg 157

                  ....*.
gi 1063725438 679 RFERRI 684
Cdd:cd19503   158 RFDREV 163
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
526-761 2.94e-48

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 171.22  E-value: 2.94e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 526 DETKESLQELVMLPLRRPDLFKGGLLKPcRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDEKNVRAL 605
Cdd:COG1223     8 EEAKKKLKLIIKELRRRENLRKFGLWPP-RKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGETARNLRKL 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 606 FTlAAKVSPTIIFVDEVDSMLGQRTRVGEHEAMRKIKNEFMTHWDGLMSNagdrILVLAATNRPFDLDEAIIRRFERRIM 685
Cdd:COG1223    87 FD-FARRAPCVIFFDEFDAIAKDRGDQNDVGEVKRVVNALLQELDGLPSG----SVVIAATNHPELLDSALWRRFDEVIE 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 686 VGLPSVESREKILRTLLSKEKTE-NLDFQELAQMTDGYSGSDLKNFCTTAAYRPVRE-------LIKQECLKDQERRKRE 757
Cdd:COG1223   162 FPLPDKEERKEILELNLKKFPLPfELDLKKLAKKLEGLSGADIEKVLKTALKKAILEdrekvtkEDLEEALKQRKERKKE 241

                  ....
gi 1063725438 758 EAEK 761
Cdd:COG1223   242 PKKE 245
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
529-686 6.18e-48

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 167.29  E-value: 6.18e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 529 KESLQELVMLPLRRPDLFKGGLLKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDEKNVRALFTL 608
Cdd:cd19529     2 KQELKEAVEWPLLKPEVFKRLGIRPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIFRK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 609 AAKVSPTIIFVDEVDSMLGQRTRVGEHEAMRKIKNEFMTHWDGLMSNAGdrILVLAATNRPFDLDEAIIR--RFERRIMV 686
Cdd:cd19529    82 ARQVAPCVIFFDEIDSIAPRRGTTGDSGVTERVVNQLLTELDGLEEMNG--VVVIAATNRPDIIDPALLRagRFDRLIYI 159
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
528-686 8.29e-48

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 166.69  E-value: 8.29e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 528 TKESLQELVMLPLRRPDLFKGGLLKPcRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDEKNVRALFT 607
Cdd:cd19481     1 LKASLREAVEAPRRGSRLRRYGLGLP-KGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 608 LAAKVSPTIIFVDEVDSMLGQRTRVGEHEAMRKIKNEFMTHWDGLmsNAGDRILVLAATNRPFDLDEAIIR--RFERRIM 685
Cdd:cd19481    80 RARRLAPCILFIDEIDAIGRKRDSSGESGELRRVLNQLLTELDGV--NSRSKVLVIAATNRPDLLDPALLRpgRFDEVIE 157

                  .
gi 1063725438 686 V 686
Cdd:cd19481   158 F 158
ftsH CHL00176
cell division protein; Validated
502-745 3.87e-47

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 178.32  E-value: 3.87e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 502 EKRIRPEVipanEIGVTFADIGSLDETKESLQELVMLpLRRPDLFKGGLLKPCRGILLFGPPGTGKTMMAKAIANEAGAS 581
Cdd:CHL00176  169 KARFQMEA----DTGITFRDIAGIEEAKEEFEEVVSF-LKKPERFTAVGAKIPKGVLLVGPPGTGKTLLAKAIAGEAEVP 243
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 582 FINVSMSTITSKWFGEDEKNVRALFTLAAKVSPTIIFVDEVDSMLGQR-TRV-GEHEAMRKIKNEFMTHWDGLMSNAGdr 659
Cdd:CHL00176  244 FFSISGSEFVEMFVGVGAARVRDLFKKAKENSPCIVFIDEIDAVGRQRgAGIgGGNDEREQTLNQLLTEMDGFKGNKG-- 321
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 660 ILVLAATNRPFDLDEAIIR--RFERRIMVGLPSVESREKILRTLLSKEK-TENLDFQELAQMTDGYSGSDLKNFCTTAAY 736
Cdd:CHL00176  322 VIVIAATNRVDILDAALLRpgRFDRQITVSLPDREGRLDILKVHARNKKlSPDVSLELIARRTPGFSGADLANLLNEAAI 401

                  ....*....
gi 1063725438 737 RPVRELIKQ 745
Cdd:CHL00176  402 LTARRKKAT 410
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
521-687 1.06e-45

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 161.06  E-value: 1.06e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 521 DIGSLDETKESLQELVMLPLRRPDLFKGGLLKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDEK 600
Cdd:cd19519     1 DIGGCRKQLAQIREMVELPLRHPELFKAIGIKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESES 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 601 NVRALFTLAAKVSPTIIFVDEVDSMLGQRTRV-GEHEamRKIKNEFMTHWDGLMSNAgdRILVLAATNRPFDLDEAIIR- 678
Cdd:cd19519    81 NLRKAFEEAEKNAPAIIFIDEIDAIAPKREKThGEVE--RRIVSQLLTLMDGLKQRA--HVIVMAATNRPNSIDPALRRf 156
                         170
                  ....*....|
gi 1063725438 679 -RFERRIMVG 687
Cdd:cd19519   157 gRFDREIDIG 166
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
517-686 1.11e-45

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 161.25  E-value: 1.11e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 517 VTFADIGSLDETKESLQELVMLpLRRPDLFK--GGllKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKW 594
Cdd:cd19501     1 VTFKDVAGCEEAKEELKEVVEF-LKNPEKFTklGA--KIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMF 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 595 FGEDEKNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRV--GEHEAMRKIKNEFMTHWDGLMSNAGdrILVLAATNRPFDL 672
Cdd:cd19501    78 VGVGASRVRDLFEQAKKNAPCIVFIDEIDAVGRKRGAGlgGGHDEREQTLNQLLVEMDGFESNTG--VIVIAATNRPDVL 155
                         170
                  ....*....|....*.
gi 1063725438 673 DEAIIR--RFERRIMV 686
Cdd:cd19501   156 DPALLRpgRFDRQVYV 171
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
506-769 1.79e-45

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 173.68  E-value: 1.79e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 506 RPEVIPANEIGVTFADIGSLDETKESLQELVMLpLRRPDLFK--GGllKPCRGILLFGPPGTGKTMMAKAIANEAGASFI 583
Cdd:PRK10733  138 KARMLTEDQIKTTFADVAGCDEAKEEVAELVEY-LREPSRFQklGG--KIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFF 214
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 584 NVSMSTITSKWFGEDEKNVRALFTLAAKVSPTIIFVDEVDSMLGQRTR--VGEHEAMRKIKNEFMTHWDGLMSNAGdrIL 661
Cdd:PRK10733  215 TISGSDFVEMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGAglGGGHDEREQTLNQMLVEMDGFEGNEG--II 292
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 662 VLAATNRPFDLDEAIIR--RFERRIMVGLPSVESREKILRTLLSKEKTE-NLDFQELAQMTDGYSGSDLKNFCTTAAY-- 736
Cdd:PRK10733  293 VIAATNRPDVLDPALLRpgRFDRQVVVGLPDVRGREQILKVHMRRVPLApDIDAAIIARGTPGFSGADLANLVNEAALfa 372
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1063725438 737 ----RPVRELIKQECLKDQ-----ERRK--REEAEKNSEEGSEA 769
Cdd:PRK10733  373 argnKRVVSMVEFEKAKDKimmgaERRSmvMTEAQKESTAYHEA 416
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
518-686 3.86e-45

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 159.81  E-value: 3.86e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 518 TFADIGSLDETKESLQELVMLPLRRPDLFKGGLLKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGE 597
Cdd:cd19502     1 TYEDIGGLDEQIREIREVVELPLKHPELFEELGIEPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 598 DEKNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRV---GEHEAMRKIKnEFMTHWDGLmsNAGDRILVLAATNRPFDLDE 674
Cdd:cd19502    81 GARLVRELFEMAREKAPSIIFIDEIDAIGAKRFDSgtgGDREVQRTML-ELLNQLDGF--DPRGNIKVIMATNRPDILDP 157
                         170
                  ....*....|....
gi 1063725438 675 AIIR--RFERRIMV 686
Cdd:cd19502   158 ALLRpgRFDRKIEF 171
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
517-765 2.93e-43

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 161.85  E-value: 2.93e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 517 VTFADIGSLDETKESLQELVMLPLRRPDLFKGGLLKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFG 596
Cdd:PTZ00454  142 VTYSDIGGLDIQKQEIREAVELPLTCPELYEQIGIDPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQKYLG 221
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 597 EDEKNVRALFTLAAKVSPTIIFVDEVDSMLGQR--TRVGEHEAMRKIKNEFMTHWDGLMSNAGdrILVLAATNRPFDLDE 674
Cdd:PTZ00454  222 EGPRMVRDVFRLARENAPSIIFIDEVDSIATKRfdAQTGADREVQRILLELLNQMDGFDQTTN--VKVIMATNRADTLDP 299
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 675 AIIR--RFERRIMVGLPSVESREKILRTLLSKEK-TENLDFQELAQMTDGYSGSDLKNFCTTA---AYRPVRELIKQecl 748
Cdd:PTZ00454  300 ALLRpgRLDRKIEFPLPDRRQKRLIFQTITSKMNlSEEVDLEDFVSRPEKISAADIAAICQEAgmqAVRKNRYVILP--- 376
                         250
                  ....*....|....*..
gi 1063725438 749 KDQERRKREEAEKNSEE 765
Cdd:PTZ00454  377 KDFEKGYKTVVRKTDRD 393
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
506-735 7.80e-43

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 164.82  E-value: 7.80e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 506 RPEVIPANEIGVTFADIGSLDETKESLQELVMLpLRRPDLFK--GGllKPCRGILLFGPPGTGKTMMAKAIANEAGASFI 583
Cdd:COG0465   128 KAKLYDEDKPKVTFDDVAGVDEAKEELQEIVDF-LKDPEKFTrlGA--KIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFF 204
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 584 NVSMSTIT--------SKwfgedeknVRALFTLAAKVSPTIIFVDEVDSmLGqRTR---VG----EHEA--------Mrk 640
Cdd:COG0465   205 SISGSDFVemfvgvgaSR--------VRDLFEQAKKNAPCIIFIDEIDA-VG-RQRgagLGgghdEREQtlnqllveM-- 272
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 641 iknefmthwDGLMSNAGdrILVLAATNRPFDLDEAIIR--RFERRIMVGLPSVESREKILRTLLSKEKT-ENLDFQELAQ 717
Cdd:COG0465   273 ---------DGFEGNEG--VIVIAATNRPDVLDPALLRpgRFDRQVVVDLPDVKGREAILKVHARKKPLaPDVDLEVIAR 341
                         250
                  ....*....|....*...
gi 1063725438 718 MTDGYSGSDLKNFCTTAA 735
Cdd:COG0465   342 RTPGFSGADLANLVNEAA 359
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
518-766 1.81e-41

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 158.01  E-value: 1.81e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 518 TFADIGSLDETKESLQELVMLPLRRPDLFKGGLLKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGE 597
Cdd:PTZ00361  181 SYADIGGLEQQIQEIKEAVELPLTHPELYDDIGIKPPKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQKYLGD 260
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 598 DEKNVRALFTLAAKVSPTIIFVDEVDSMLGQR---TRVGEHEAMRKIKnEFMTHWDGLMSNaGDrILVLAATNRPFDLDE 674
Cdd:PTZ00361  261 GPKLVRELFRVAEENAPSIVFIDEIDAIGTKRydaTSGGEKEIQRTML-ELLNQLDGFDSR-GD-VKVIMATNRIESLDP 337
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 675 AIIR--RFERRIMVGLPSVESREKILRTLLSKEK-TENLDFQELAQMTDGYSGSDLKNFCTTA---AYRPVRELIKQECL 748
Cdd:PTZ00361  338 ALIRpgRIDRKIEFPNPDEKTKRRIFEIHTSKMTlAEDVDLEEFIMAKDELSGADIKAICTEAgllALRERRMKVTQADF 417
                         250
                  ....*....|....*...
gi 1063725438 749 KDQERRKREEAEKNSEEG 766
Cdd:PTZ00361  418 RKAKEKVLYRKKGNIPEG 435
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
529-686 6.98e-41

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 147.27  E-value: 6.98e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 529 KESLQELVMLPLRRPDLFKGGLLKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDEKNVRALFTL 608
Cdd:cd19528     2 KRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 609 AAKVSPTIIFVDEVDSMLGQR--TRVGEHEAMRKIKNEFMTHWDGLmsNAGDRILVLAATNRPFDLDEAIIR--RFERRI 684
Cdd:cd19528    82 ARAAAPCVLFFDELDSIAKARggNIGDAGGAADRVINQILTEMDGM--NTKKNVFIIGATNRPDIIDPAILRpgRLDQLI 159

                  ..
gi 1063725438 685 MV 686
Cdd:cd19528   160 YI 161
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
521-686 4.66e-40

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 145.03  E-value: 4.66e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 521 DIGSLDETKESLQELVMLPLRRPDLFKGgLLKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDEK 600
Cdd:cd19523     1 DIAGLGALKAAIKEEVLWPLLRPDAFSG-LLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 601 NVRALFTLAAKVSPTIIFVDEVDSMLGqrTRVGEHEAMRKIKNEFMTHWDGLMSNAGDRILVLAATNRPFDLDEAIIRRF 680
Cdd:cd19523    80 ILQASFLAARCRQPSVLFISDLDALLS--SQDDEASPVGRLQVELLAQLDGVLGSGEDGVLVVCTTSKPEEIDESLRRYF 157

                  ....*.
gi 1063725438 681 ERRIMV 686
Cdd:cd19523   158 SKRLLV 163
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
521-684 2.05e-39

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 143.70  E-value: 2.05e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 521 DIGSLDETKESLQELVMLPLRRPDLFKGGLLKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDEK 600
Cdd:cd19518     1 DIGGMDSTLKELCELLIHPILPPEYFQHLGVEPPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESEE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 601 NVRALFTLAAKVSPTIIFVDEVDSMLGQRtRVGEHEAMRKIKNEFMTHWDGL--MSNAGDRILVLAATNRPFDLDEAIIR 678
Cdd:cd19518    81 KIRELFDQAISNAPCIVFIDEIDAITPKR-ESAQREMERRIVSQLLTCMDELnnEKTAGGPVLVIGATNRPDSLDPALRR 159

                  ....*...
gi 1063725438 679 --RFERRI 684
Cdd:cd19518   160 agRFDREI 167
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
525-686 1.44e-37

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 138.00  E-value: 1.44e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 525 LDETKESLQELVMLPLRRPDLFKG-GLLKPcRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDEKNVR 603
Cdd:cd19530     1 LDHVREELTMSILRPIKRPDIYKAlGIDLP-TGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 604 ALFTLAAKVSPTIIFVDEVDSMLGQRTRvGEHEAMRKIKNEFMTHWDGLMSNAGdrILVLAATNRPFDLDEAIIR--RFE 681
Cdd:cd19530    80 QVFQRARASAPCVIFFDEVDALVPKRGD-GGSWASERVVNQLLTEMDGLEERSN--VFVIAATNRPDIIDPAMLRpgRLD 156

                  ....*
gi 1063725438 682 RRIMV 686
Cdd:cd19530   157 KTLYV 161
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
529-686 7.53e-34

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 127.24  E-value: 7.53e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 529 KESLQELVMLPLRRPDLFKGGLLKPcRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDEKNVRALFTL 608
Cdd:cd19527     2 KKEILDTIQLPLEHPELFSSGLRKR-SGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 609 AAKVSPTIIFVDEVDSMLGQRTRVGEHEA-MRKIKNEFMTHWDGlMSNAGDRILVLAATNRPFDLDEAIIR--RFERRIM 685
Cdd:cd19527    81 ARDAKPCVIFFDELDSLAPSRGNSGDSGGvMDRVVSQLLAELDG-MSSSGQDVFVIGATNRPDLLDPALLRpgRFDKLLY 159

                  .
gi 1063725438 686 V 686
Cdd:cd19527   160 L 160
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
521-682 5.57e-32

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 122.23  E-value: 5.57e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 521 DIGSLDETKESLQELVMLPLRRPDLFKGGLLKPCRGILLFGPPGTGKTMMAKAIANEAGA-----SFINVSMSTITSKWF 595
Cdd:cd19517     1 DIGGLSHYINQLKEMVFFPLLYPEVFAKFKITPPRGVLFHGPPGTGKTLMARALAAECSKggqkvSFFMRKGADCLSKWV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 596 GEDEKNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRVGEhEAMRKIKNEFMTHWDGLMSNAgdRILVLAATNRPFDLDEA 675
Cdd:cd19517    81 GEAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVRSSKQE-QIHASIVSTLLALMDGLDNRG--QVVVIGATNRPDALDPA 157

                  ....*....
gi 1063725438 676 IIR--RFER 682
Cdd:cd19517   158 LRRpgRFDR 166
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
529-684 2.52e-30

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 117.14  E-value: 2.52e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 529 KESLQELVMLPLRRPDLFKGGLLKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDEKNVRALFTL 608
Cdd:cd19526     2 KKALEETIEWPSKYPKIFASSPLRLRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFSR 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 609 AAKVSPTIIFVDEVDSMLGQR----TRVGEheamrKIKNEFMTHWDGlmSNAGDRILVLAATNRPFDLDEAIIR--RFER 682
Cdd:cd19526    82 AQSAKPCILFFDEFDSIAPKRghdsTGVTD-----RVVNQLLTQLDG--VEGLDGVYVLAATSRPDLIDPALLRpgRLDK 154

                  ..
gi 1063725438 683 RI 684
Cdd:cd19526   155 LV 156
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
555-688 4.52e-23

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 96.06  E-value: 4.52e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 555 RGILLFGPPGTGKTMMAKAIANEA---GASFINVSMSTITSKWFGEDEKN---VRALFTLAAKVSPTIIFVDEVDSMlgq 628
Cdd:cd00009    20 KNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAELFGhflVRLLFELAEKAKPGVLFIDEIDSL--- 96
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063725438 629 rtRVGEHEAMRKIKNEFMThwdglMSNAGDRILVLAATNRPF--DLDEAIIRRFERRIMVGL 688
Cdd:cd00009    97 --SRGAQNALLRVLETLND-----LRIDRENVRVIGATNRPLlgDLDRALYDRLDIRIVIPL 151
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
521-682 1.47e-21

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 92.05  E-value: 1.47e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 521 DIGSLDETKESLQelvmlplRR-----PDLFKGGLLKPcRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWF 595
Cdd:cd19507     1 DVGGLDNLKDWLK-------KRkaafsKQASAYGLPTP-KGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLV 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 596 GEDEKNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRVGEHEAMRKIKNEFMThWdglMSNAGDRILVLAATNRPFDLDEA 675
Cdd:cd19507    73 GESESRLRQMIQTAEAIAPCVLWIDEIEKGFSNADSKGDSGTSSRVLGTFLT-W---LQEKKKPVFVVATANNVQSLPPE 148

                  ....*....
gi 1063725438 676 IIR--RFER 682
Cdd:cd19507   149 LLRkgRFDE 157
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
551-681 2.98e-19

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 86.00  E-value: 2.98e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 551 LKPCRGILLFGPPGTGKTMMAKAIANEAGASFIN-VSMSTITSKWFGEDEKNVRALF--------TLAAKVSPTIIFVDE 621
Cdd:cd19504    32 CKHVKGILLYGPPGTGKTLMARQIGKMLNAREPKiVNGPEILNKYVGESEANIRKLFadaeeeqrRLGANSGLHIIIFDE 111
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063725438 622 VDSMLGQR-TRVGEHEAMRKIKNEFMTHWDGLmsNAGDRILVLAATNRPFDLDEAIIR--RFE 681
Cdd:cd19504   112 IDAICKQRgSMAGSTGVHDTVVNQLLSKIDGV--EQLNNILVIGMTNRKDLIDEALLRpgRLE 172
ycf46 CHL00195
Ycf46; Provisional
508-728 1.63e-18

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 89.69  E-value: 1.63e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 508 EVIPANEigvTFADIGSLDETKESLQelvmlplRRPDLFKG-----GLLKPcRGILLFGPPGTGKTMMAKAIANEAGASF 582
Cdd:CHL00195  219 EFYSVNE---KISDIGGLDNLKDWLK-------KRSTSFSKqasnyGLPTP-RGLLLVGIQGTGKSLTAKAIANDWQLPL 287
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 583 INVSMSTITSKWFGEDEKNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRVGEHEAMRKIKNEFMThWdglMSNAGDRILV 662
Cdd:CHL00195  288 LRLDVGKLFGGIVGESESRMRQMIRIAEALSPCILWIDEIDKAFSNSESKGDSGTTNRVLATFIT-W---LSEKKSPVFV 363
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063725438 663 LAATNRPFDLDEAIIR--RFERRIMVGLPSVESREKILRTLLSK---EKTENLDFQELAQMTDGYSGSDLK 728
Cdd:CHL00195  364 VATANNIDLLPLEILRkgRFDEIFFLDLPSLEEREKIFKIHLQKfrpKSWKKYDIKKLSKLSNKFSGAEIE 434
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
555-689 1.84e-18

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 82.81  E-value: 1.84e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438  555 RGILLFGPPGTGKTMMAKAIANEA---GASFINVSMSTITS--------------KWFGEDEKNVRALFTLAAKVSPTII 617
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELgppGGGVIYIDGEDILEevldqllliivggkKASGSGELRLRLALALARKLKPDVL 82
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063725438  618 FVDEVDSMLGQRTRVGEHEAMRKIKnefmthwdGLMSNAGDRILVLAATNRPFDLDEAIIR-RFERRIMVGLP 689
Cdd:smart00382  83 ILDEITSLLDAEQEALLLLLEELRL--------LLLLKSEKNLTVILTTNDEKDLGPALLRrRFDRRIVLLLI 147
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
553-684 4.60e-13

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 67.55  E-value: 4.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 553 PCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSkwFGEDE-KNVRALFTLAAKVSP-TIIFVDEVDSMLGQRT 630
Cdd:cd19512    21 LYRNILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAP--MGREGvTAIHKVFDWANTSRRgLLLFVDEADAFLRKRS 98
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1063725438 631 RVGEHEAMRKIKNEFMTHwdglMSNAGDRILVLAATNRPFDLDEAIIRRFERRI 684
Cdd:cd19512    99 TEKISEDLRAALNAFLYR----TGEQSNKFMLVLASNQPEQFDWAINDRIDEMV 148
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
555-685 4.15e-11

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 62.16  E-value: 4.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 555 RGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGED--EKNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRV 632
Cdd:cd19506    27 KSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNglQMMLHLVLKVARQLQPSVIWIGDAEKTFYKKVPK 106
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1063725438 633 GEHEA-MRKIKNEFMTHWDGLMSNagDRILVLAATNRPFDLDEAIIRRFERRIM 685
Cdd:cd19506   107 TEKQLdPKRLKKDLPKILKSLKPE--DRVLIVGTTSRPFEADLKSFCKVYNKII 158
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
555-679 2.34e-10

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 60.92  E-value: 2.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 555 RGILLFGPPGTGKTMMAKAIANE---------AGASFINVSMSTITSKWFGEDEKNVRALFTLA---AKVSPTIIFV--D 620
Cdd:cd19508    53 RLVLLHGPPGTGKTSLCKALAQKlsirlssryRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIqelIDDKDALVFVliD 132
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063725438 621 EVDSMLGQRT----RVGEHEAMRKIkNEFMTHWDGLMSNagDRILVLAATNRPFDLDEAIIRR 679
Cdd:cd19508   133 EVESLAAARSasssGTEPSDAIRVV-NAVLTQIDRIKRY--HNNVILLTSNLLEKIDVAFVDR 192
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
709-752 3.82e-10

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 55.62  E-value: 3.82e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1063725438 709 NLDFQELAQMTDGYSGSDLKNFCTTAAYRPVRELIKQECLKDQE 752
Cdd:pfam17862   1 DVDLEELAERTEGFSGADLEALCREAALAALRRGLEAVTQEDLE 44
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
555-686 1.63e-09

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 57.36  E-value: 1.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 555 RGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSkwfgeDEKNVRALFTLAAKVSptIIFVDEVDSMLGQRtrvgE 634
Cdd:cd19510    24 RGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEVVL-----TDDRLNHLLNTAPKQS--IILLEDIDAAFESR----E 92
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063725438 635 HEAMRKIKNEFMTH--WDGLMsNAGD-------RILVLaATNRPFDLDEAIIR--RFERRIMV 686
Cdd:cd19510    93 HNKKNPSAYGGLSRvtFSGLL-NALDgvasseeRIVFM-TTNHIERLDPALIRpgRVDMKIYM 153
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
539-622 2.22e-09

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 60.45  E-value: 2.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 539 PLRRpdLFKGGLLkpcRGILLFGPPGTGKTMMAKAIANEAGASFINVS--MSTItskwfgedeKNVRALFTLAAKVS--- 613
Cdd:COG2256    39 PLRR--AIEAGRL---SSMILWGPPGTGKTTLARLIANATDAEFVALSavTSGV---------KDIREVIEEARERRayg 104
                          90
                  ....*....|
gi 1063725438 614 -PTIIFVDEV 622
Cdd:COG2256   105 rRTILFVDEI 114
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
539-622 2.70e-09

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 60.10  E-value: 2.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 539 PLRRpdLFKGGLLkpcRGILLFGPPGTGKTMMAKAIANEAGASFINVSmSTITSKwfgedeKNVRALFTLAAKVS----P 614
Cdd:PRK13342   26 PLRR--MIEAGRL---SSMILWGPPGTGKTTLARIIAGATDAPFEALS-AVTSGV------KDLREVIEEARQRRsagrR 93

                  ....*...
gi 1063725438 615 TIIFVDEV 622
Cdd:PRK13342   94 TILFIDEI 101
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
529-699 3.73e-08

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 55.56  E-value: 3.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 529 KESLQELVMLplrrpdlfkgGLLkpCRG-ILLFGPPGTGKTMMAKAIANEAGASFINV-----SM------STITSKWFG 596
Cdd:COG0714    17 QEELIELVLI----------ALL--AGGhLLLEGVPGVGKTTLAKALARALGLPFIRIqftpdLLpsdilgTYIYDQQTG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 597 EDEKNVRALFTlaakvspTIIFVDEVD--------SMLgqrtrvgehEAM--RKIKNEFMTHwdglmsNAGDRILVLAAT 666
Cdd:COG0714    85 EFEFRPGPLFA-------NVLLADEINrappktqsALL---------EAMeeRQVTIPGGTY------KLPEPFLVIATQ 142
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1063725438 667 NRP-----FDLDEAIIRRFERRIMVGLPSVESREKILR 699
Cdd:COG0714   143 NPIeqegtYPLPEAQLDRFLLKLYIGYPDAEEEREILR 180
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
557-582 2.06e-05

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 45.57  E-value: 2.06e-05
                          10        20
                  ....*....|....*....|....*.
gi 1063725438 557 ILLFGPPGTGKTMMAKAIANEAGASF 582
Cdd:pfam05496  36 VLLYGPPGLGKTTLANIIANEMGVNI 61
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
555-592 3.28e-05

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 47.27  E-value: 3.28e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1063725438 555 RGILLFGPPGTGKTMMAKAIANEAGAS--FINVSMSTITS 592
Cdd:COG1224    65 KGILIVGPPGTGKTALAVAIARELGEDtpFVAISGSEIYS 104
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
557-592 3.38e-05

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 46.66  E-value: 3.38e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1063725438 557 ILLFGPPGTGKTMMAKAIANEAGASFinvsmsTITS 592
Cdd:PRK00080   54 VLLYGPPGLGKTTLANIIANEMGVNI------RITS 83
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
557-623 4.17e-05

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 44.88  E-value: 4.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 557 ILLFGPPGTGKTMMAKAIANEAGAS---FINVSMSTIT-----SKWFGEDEKNVRA----LFTLAAKVSP-TIIFVDEVD 623
Cdd:pfam07724   6 FLFLGPTGVGKTELAKALAELLFGDeraLIRIDMSEYMeehsvSRLIGAPPGYVGYeeggQLTEAVRRKPySIVLIDEIE 85
T7SS_EccA TIGR03922
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ...
555-684 4.90e-05

type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188437 [Multi-domain]  Cd Length: 557  Bit Score: 46.76  E-value: 4.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 555 RGILLFGPPGTGKTMMAKAIANE-AGASFI------NVSMSTITSKWFGEDEKNVRALFTLAAKvspTIIFVDEVDSMLG 627
Cdd:TIGR03922 313 NHMLFAGPPGTGKTTIARVVAKIyCGLGVLrkplvrEVSRADLIGQYIGESEAKTNEIIDSALG---GVLFLDEAYTLVE 389
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063725438 628 QRTRVGEHEAMRKIkNEFMTHwdglMSNAGDRILVLAA-----TNRPFDLDEAIIRRFERRI 684
Cdd:TIGR03922 390 TGYGQKDPFGLEAI-DTLLAR----MENDRDRLVVIGAgyrkdLDKFLEVNEGLRSRFTRVI 446
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
544-578 5.25e-05

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 45.54  E-value: 5.25e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1063725438 544 DLFKGGLLKPCRGILLFGPPGTGKTMMAKAIANEA 578
Cdd:COG1484    89 ELATLDFIERGENLILLGPPGTGKTHLAIALGHEA 123
PRK04195 PRK04195
replication factor C large subunit; Provisional
552-721 5.34e-05

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 46.45  E-value: 5.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 552 KPCRGILLFGPPGTGKTMMAKAIANEAGASFI--NVS-------------MSTITSKWFGEDEKnvralftlaakvsptI 616
Cdd:PRK04195   37 KPKKALLLYGPPGVGKTSLAHALANDYGWEVIelNASdqrtadviervagEAATSGSLFGARRK---------------L 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 617 IFVDEVDSMLGQRTRVGEHEAMRKIKnefmthwdglmsNAGDRIlVLAAtNRPFDLDEAIIRrfERRIMVGLPSVESRE- 695
Cdd:PRK04195  102 ILLDEVDGIHGNEDRGGARAILELIK------------KAKQPI-ILTA-NDPYDPSLRELR--NACLMIEFKRLSTRSi 165
                         170       180
                  ....*....|....*....|....*....
gi 1063725438 696 -KILRTLLSKEKTENLD--FQELAQMTDG 721
Cdd:PRK04195  166 vPVLKRICRKEGIECDDeaLKEIAERSGG 194
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
551-686 8.60e-05

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 43.90  E-value: 8.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 551 LKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWF-----------GEDEKNVRAL---FTLAAKVSPTI 616
Cdd:cd19505     9 LSPSKGILLIGSIETGRSYLIKSLAANSYVPLIRISLNKLLYNKPdfgnddwidgmLILKESLHRLnlqFELAKAMSPCI 88
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063725438 617 IFVD---EVDS-MLGQRTRVGEHEAMRKIKNEFMThwdGLMSNAGDRILVLAATNRPFDLDEAII--RRFERRIMV 686
Cdd:cd19505    89 IWIPnihELNVnRSTQNLEEDPKLLLGLLLNYLSR---DFEKSSTRNILVIASTHIPQKVDPALIapNRLDTCINI 161
RuvB COG2255
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ...
557-592 1.11e-04

Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];


Pssm-ID: 441856 [Multi-domain]  Cd Length: 337  Bit Score: 45.07  E-value: 1.11e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1063725438 557 ILLFGPPGTGKTMMAKAIANEAGASFinvsmsTITS 592
Cdd:COG2255    57 VLLYGPPGLGKTTLAHIIANEMGVNI------RITS 86
RecA-like_HslU cd19498
ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease ...
557-633 1.25e-04

ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease HslVU. In HslVU, HslU ATPase serves to unfold and translocate protein substrate, and the HslV protease degrades the unfolded proteins. This RecA-like_HslU subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410906 [Multi-domain]  Cd Length: 183  Bit Score: 43.52  E-value: 1.25e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063725438 557 ILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWF-GED-EKNVRALFTlaakvspTIIFVDEVDSMLGQRTRVG 633
Cdd:cd19498    49 ILMIGPTGVGKTEIARRLAKLAGAPFIKVEATKFTEVGYvGRDvESIIRDLVE-------GIVFIDEIDKIAKRGGSSG 120
44 PHA02544
clamp loader, small subunit; Provisional
557-642 1.92e-04

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 44.21  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 557 ILLFGP-PGTGKTMMAKAIANEAGAS--FINVSMSTITskwFGEDE-KNVRALFTLAAKvsPTIIFVDEVDsmlgqrtRV 632
Cdd:PHA02544   45 MLLHSPsPGTGKTTVAKALCNEVGAEvlFVNGSDCRID---FVRNRlTRFASTVSLTGG--GKVIIIDEFD-------RL 112
                          90
                  ....*....|
gi 1063725438 633 GEHEAMRKIK 642
Cdd:PHA02544  113 GLADAQRHLR 122
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
435-580 3.06e-04

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 44.38  E-value: 3.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 435 FEDSLKLDTNIDSKVEEGEGITKSESKSETTVPENKNESDTSIPAAKNECPLPPKAPVHEVAPDNEFEKRIRPEVIPANE 514
Cdd:COG1401   105 YELEADSEIEAVGLLLELAERSDALEALERARLLLELADLEERAALETEVLEALEAELEELLAAPEDLSADALAAELSAA 184
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063725438 515 IGVTFADIGSLDE-TKESLQELVMLPLRRpdlfKGGLLKPCRGILLFGPPGTGKTMMAKAIANEAGA 580
Cdd:COG1401   185 EELYSEDLESEDDyLKDLLREKFEETLEA----FLAALKTKKNVILAGPPGTGKTYLARRLAEALGG 247
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
524-625 5.43e-04

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 41.78  E-value: 5.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 524 SLDETKESLQELVMLPLRRPDLfKGGLLkpcrgiLLFGPPGTGKTMMAKAIANEAGASFINVSMSTITskwfgeDEKNVR 603
Cdd:cd19500    14 GLEDVKERILEYLAVRKLKGSM-KGPIL------CLVGPPGVGKTSLGKSIARALGRKFVRISLGGVR------DEAEIR 80
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1063725438 604 ----------------ALFTlaAKVSPTIIFVDEVDSM 625
Cdd:cd19500    81 ghrrtyvgampgriiqALKK--AGTNNPVFLLDEIDKI 116
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
555-592 6.58e-04

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 42.68  E-value: 6.58e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1063725438 555 RGILLFGPPGTGKTMMAKAIANEAGAS--FINVSMSTITS 592
Cdd:pfam06068  51 RAVLIAGPPGTGKTALAIAISKELGEDtpFTSISGSEVYS 90
ruvB TIGR00635
Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions ...
557-622 8.17e-04

Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs serve as a 5'-3' Holliday junction helicase. RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129721 [Multi-domain]  Cd Length: 305  Bit Score: 42.29  E-value: 8.17e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063725438 557 ILLFGPPGTGKTMMAKAIANEAGASFinvsmsTITSKWFGEDEKNVRALFTLAAKVSptIIFVDEV 622
Cdd:TIGR00635  33 LLLYGPPGLGKTTLAHIIANEMGVNL------KITSGPALEKPGDLAAILTNLEEGD--VLFIDEI 90
RecA-like_ClpX cd19497
ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent ...
557-623 1.08e-03

ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent protease ClpXP. In ClpXP, ClpX ATPase serves to specifically recognize, unfold, and translocate protein substrates into the chamber of ClpP protease for degradation. This RecA-like_ClpX domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410905 [Multi-domain]  Cd Length: 251  Bit Score: 41.82  E-value: 1.08e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063725438 557 ILLFGPPGTGKTMMAKAIANEAGASFINVSMSTIT-SKWFGEDEKNVRALFTLAA-----KVSPTIIFVDEVD 623
Cdd:cd19497    53 ILLIGPTGSGKTLLAQTLAKILDVPFAIADATTLTeAGYVGEDVENILLKLLQAAdydveRAQRGIVYIDEID 125
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
544-578 1.10e-03

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 41.30  E-value: 1.10e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1063725438 544 DLFKGGLLKPCRGILLFGPPGTGKTMMAKAIANEA 578
Cdd:NF038214   80 ELATLDFIERAENVLLLGPPGTGKTHLAIALGYAA 114
PRK08116 PRK08116
hypothetical protein; Validated
555-599 1.15e-03

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 41.54  E-value: 1.15e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1063725438 555 RGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTIT----------SKWFGEDE 599
Cdd:PRK08116  115 VGLLLWGSVGTGKTYLAACIANELIEKGVPVIFVNFPqllnrikstyKSSGKEDE 169
YifB COG0606
Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational ...
557-574 1.41e-03

Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440371 [Multi-domain]  Cd Length: 502  Bit Score: 41.95  E-value: 1.41e-03
                          10
                  ....*....|....*...
gi 1063725438 557 ILLFGPPGTGKTMMAKAI 574
Cdd:COG0606   214 LLMIGPPGSGKTMLARRL 231
ABC_ATPase cd00267
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ...
557-663 1.50e-03

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213179 [Multi-domain]  Cd Length: 157  Bit Score: 39.92  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 557 ILLFGPPGTGKTMMAKAIANEAGASFINVSMS--TITSKWFGEDEKNV----------RALFTLAAKV--SPTIIFVDEV 622
Cdd:cd00267    28 VALVGPNGSGKSTLLRAIAGLLKPTSGEILIDgkDIAKLPLEELRRRIgyvpqlsggqRQRVALARALllNPDLLLLDEP 107
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1063725438 623 DSMLGQRTRVGEHEAMRKIKNEFM-----THWDGLMSNAGDRILVL 663
Cdd:cd00267   108 TSGLDPASRERLLELLRELAEEGRtviivTHDPELAELAADRVIVL 153
Mg_chelatase pfam01078
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that ...
557-574 1.58e-03

Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that catalyzes the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.


Pssm-ID: 426032 [Multi-domain]  Cd Length: 207  Bit Score: 40.60  E-value: 1.58e-03
                          10
                  ....*....|....*...
gi 1063725438 557 ILLFGPPGTGKTMMAKAI 574
Cdd:pfam01078  25 LLMIGPPGSGKTMLAKRL 42
Sigma54_activat pfam00158
Sigma-54 interaction domain;
557-676 1.91e-03

Sigma-54 interaction domain;


Pssm-ID: 425491 [Multi-domain]  Cd Length: 168  Bit Score: 39.69  E-value: 1.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 557 ILLFGPPGTGKTMMAKAIANE---AGASFINVSM-----STITSKWFG---------EDEKnvRALFTLAAKvspTIIFV 619
Cdd:pfam00158  25 VLITGESGTGKELFARAIHQLsprADGPFVAVNCaaipeELLESELFGhekgaftgaDSDR--KGLFELADG---GTLFL 99
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 620 DEVDSM-------L------GQRTRVGEHEAmRKIknefmthwdglmsnagdRILVLAATNRpfDLDEAI 676
Cdd:pfam00158 100 DEIGELplelqakLlrvlqeGEFERVGGTKP-IKV-----------------DVRIIAATNR--DLEEAV 149
clpC CHL00095
Clp protease ATP binding subunit
555-710 2.08e-03

Clp protease ATP binding subunit


Pssm-ID: 214361 [Multi-domain]  Cd Length: 821  Bit Score: 41.58  E-value: 2.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 555 RGILLFGPPGTGKTMMAKA----IANEAGASF--------INVSMSTITSKWFGEDEKNVRALFTLAAKVSPTIIFVDEV 622
Cdd:CHL00095  201 NNPILIGEPGVGKTAIAEGlaqrIVNRDVPDIledklvitLDIGLLLAGTKYRGEFEERLKRIFDEIQENNNIILVIDEV 280
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 623 DSMLGQRTRVGEHEAMRKIKNEFmthwdglmsnAGDRILVLAATN-----RPFDLDEAIIRRFErRIMVGLPSVESREKI 697
Cdd:CHL00095  281 HTLIGAGAAEGAIDAANILKPAL----------ARGELQCIGATTldeyrKHIEKDPALERRFQ-PVYVGEPSVEETIEI 349
                         170
                  ....*....|....
gi 1063725438 698 LRTLLSK-EKTENL 710
Cdd:CHL00095  350 LFGLRSRyEKHHNL 363
PRK13341 PRK13341
AAA family ATPase;
548-622 2.69e-03

AAA family ATPase;


Pssm-ID: 237354 [Multi-domain]  Cd Length: 725  Bit Score: 41.19  E-value: 2.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 548 GGLLKpcRGI--------LLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKwfgeDEKNV--RALFTLAAKVSPTII 617
Cdd:PRK13341   40 GRLLR--RAIkadrvgslILYGPPGVGKTTLARIIANHTRAHFSSLNAVLAGVK----DLRAEvdRAKERLERHGKRTIL 113

                  ....*
gi 1063725438 618 FVDEV 622
Cdd:PRK13341  114 FIDEV 118
rfc PRK00440
replication factor C small subunit; Reviewed
518-625 3.62e-03

replication factor C small subunit; Reviewed


Pssm-ID: 234763 [Multi-domain]  Cd Length: 319  Bit Score: 40.24  E-value: 3.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 518 TFADIGSLDETKESLQELVmlplRRPDLfkggllkPCrgiLLF-GPPGTGKTMMAKAIANEAgasfinvsmstitskwFG 596
Cdd:PRK00440   15 TLDEIVGQEEIVERLKSYV----KEKNM-------PH---LLFaGPPGTGKTTAALALAREL----------------YG 64
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1063725438 597 ED------EKN---------VRALFTLAAKVSPT------IIFVDEVDSM 625
Cdd:PRK00440   65 EDwrenflELNasdergidvIRNKIKEFARTAPVggapfkIIFLDEADNL 114
clpA PRK11034
ATP-dependent Clp protease ATP-binding subunit; Provisional
558-704 6.25e-03

ATP-dependent Clp protease ATP-binding subunit; Provisional


Pssm-ID: 236828 [Multi-domain]  Cd Length: 758  Bit Score: 40.21  E-value: 6.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 558 LLFGPPGTGKTMMAKAIANE--AGASFINVSMSTITS----------KWFGEDEKNVRALFTLAAKVSPTIIFVDEVDSM 625
Cdd:PRK11034  211 LLVGESGVGKTAIAEGLAWRivQGDVPEVMADCTIYSldigsllagtKYRGDFEKRFKALLKQLEQDTNSILFIDEIHTI 290
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 626 LGQ-RTRVGEHEAMRKIKNefmthwdgLMSNAgdRILVLAAT-----NRPFDLDEAIIRRFErRIMVGLPSVESREKILR 699
Cdd:PRK11034  291 IGAgAASGGQVDAANLIKP--------LLSSG--KIRVIGSTtyqefSNIFEKDRALARRFQ-KIDITEPSIEETVQIIN 359

                  ....*
gi 1063725438 700 TLLSK 704
Cdd:PRK11034  360 GLKPK 364
RecA-like_superfamily cd01120
RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 ...
557-645 8.50e-03

RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410865 [Multi-domain]  Cd Length: 119  Bit Score: 37.10  E-value: 8.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725438 557 ILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWfgedeknVRALFTLAAKVSPTIIFVDEVDSMLGQRTRVGEHE 636
Cdd:cd01120     1 ILITGPPGSGKTTLLLQFAEQALLSDEPVIFISFLDTI-------LEAIEDLIEEKKLDIIIIDSLSSLARASQGDRSSE 73

                  ....*....
gi 1063725438 637 AMRKIKNEF 645
Cdd:cd01120    74 LLEDLAKLL 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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