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Conserved domains on  [gi|1063726921|ref|NP_001329237|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
55-403 2.91e-25

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.07  E-value: 2.91e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921  55 LEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWDWQLGNVKLSFhSGHANNVFQAKFMPfsDDRTIVTCAADGMVRRASIL 134
Cdd:COG2319   116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL-TGHSGAVTSVAFSP--DGKLLASGSDDGTVRLWDLA 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 135 EGDKVETsfLGLHQGRAHKLCIEPGNPHIFyTCGEDGLVQRFDLRTEAPTELFTcrsvdprrrnMDAIQLNAIAIDPrNS 214
Cdd:COG2319   193 TGKLLRT--LTGHTGAVRSVAFSPDGKLLA-SGSADGTVRLWDLATGKLLRTLT----------GHSGSVRSVAFSP-DG 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 215 NLFAVGGMEEYARLYDIRRFQgeglngftraadhfcPPHLIGNEDVGITGLAFSEQSELLVS-YNDEFIYLFTPGMGlgs 293
Cdd:COG2319   259 RLLASGSADGTVRLWDLATGE---------------LLRTLTGHSGGVNSVAFSPDGKLLASgSDDGTVRLWDLATG--- 320

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 294 npipsspiskspvsksesssspkdenehSVSLVYKGHKNceTVKGVNfFGPRSEYVVSGSDCGRIFIWRKKGGELIRVME 373
Cdd:COG2319   321 ----------------------------KLLRTLTGHTG--AVRSVA-FSPDGKTLASGSDDGTVRLWDLATGELLRTLT 369

                         330       340       350
                  ....*....|....*....|....*....|
gi 1063726921 374 ADRHVVNCIEPHPHIPVLASSGIESDIKVW 403
Cdd:COG2319   370 GHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
55-403 2.91e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.07  E-value: 2.91e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921  55 LEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWDWQLGNVKLSFhSGHANNVFQAKFMPfsDDRTIVTCAADGMVRRASIL 134
Cdd:COG2319   116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL-TGHSGAVTSVAFSP--DGKLLASGSDDGTVRLWDLA 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 135 EGDKVETsfLGLHQGRAHKLCIEPGNPHIFyTCGEDGLVQRFDLRTEAPTELFTcrsvdprrrnMDAIQLNAIAIDPrNS 214
Cdd:COG2319   193 TGKLLRT--LTGHTGAVRSVAFSPDGKLLA-SGSADGTVRLWDLATGKLLRTLT----------GHSGSVRSVAFSP-DG 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 215 NLFAVGGMEEYARLYDIRRFQgeglngftraadhfcPPHLIGNEDVGITGLAFSEQSELLVS-YNDEFIYLFTPGMGlgs 293
Cdd:COG2319   259 RLLASGSADGTVRLWDLATGE---------------LLRTLTGHSGGVNSVAFSPDGKLLASgSDDGTVRLWDLATG--- 320

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 294 npipsspiskspvsksesssspkdenehSVSLVYKGHKNceTVKGVNfFGPRSEYVVSGSDCGRIFIWRKKGGELIRVME 373
Cdd:COG2319   321 ----------------------------KLLRTLTGHTG--AVRSVA-FSPDGKTLASGSDDGTVRLWDLATGELLRTLT 369

                         330       340       350
                  ....*....|....*....|....*....|
gi 1063726921 374 ADRHVVNCIEPHPHIPVLASSGIESDIKVW 403
Cdd:COG2319   370 GHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 55-403 2.53e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.46  E-value: 2.53e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921  55 LEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWDWQLGNVKLSFhSGHANNVfqAKFMPFSDDRTIVTCAADGMVRRASiL 134
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPV--RDVAASADGTYLASGSSDKTIRLWD-L 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 135 EGDKVETSFLGlHQGRAHKLCIEPgNPHIFYTCGEDGLVQRFDLRTEAPTELFTCRSvdprrrnmDAIqlNAIAIDPrnS 214
Cdd:cd00200    81 ETGECVRTLTG-HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHT--------DWV--NSVAFSP--D 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 215 NLFAVGGMEE-YARLYDIRRFQGEGLngftraadhfcpphLIGNEDvGITGLAFSEQ-SELLVSYNDEFIYLFTPGMGlg 292
Cdd:cd00200   147 GTFVASSSQDgTIKLWDLRTGKCVAT--------------LTGHTG-EVNSVAFSPDgEKLLSSSSDGTIKLWDLSTG-- 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 293 snpipsspiskspvsksesssspkdenehSVSLVYKGHKNcetvkGVNF--FGPRSEYVVSGSDCGRIFIWRKKGGELIR 370
Cdd:cd00200   210 -----------------------------KCLGTLRGHEN-----GVNSvaFSPDGYLLASGSEDGTIRVWDLRTGECVQ 255

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1063726921 371 VMEADRHVVNCIEPHPHIPVLASSGIESDIKVW 403
Cdd:cd00200   256 TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 pfam00400
WD domain, G-beta repeat;
50-87 3.89e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 3.89e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1063726921  50 EIYKKLEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWD 87
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 53-87 4.48e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 4.48e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1063726921   53 KKLEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWD 87
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
55-403 2.91e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.07  E-value: 2.91e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921  55 LEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWDWQLGNVKLSFhSGHANNVFQAKFMPfsDDRTIVTCAADGMVRRASIL 134
Cdd:COG2319   116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL-TGHSGAVTSVAFSP--DGKLLASGSDDGTVRLWDLA 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 135 EGDKVETsfLGLHQGRAHKLCIEPGNPHIFyTCGEDGLVQRFDLRTEAPTELFTcrsvdprrrnMDAIQLNAIAIDPrNS 214
Cdd:COG2319   193 TGKLLRT--LTGHTGAVRSVAFSPDGKLLA-SGSADGTVRLWDLATGKLLRTLT----------GHSGSVRSVAFSP-DG 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 215 NLFAVGGMEEYARLYDIRRFQgeglngftraadhfcPPHLIGNEDVGITGLAFSEQSELLVS-YNDEFIYLFTPGMGlgs 293
Cdd:COG2319   259 RLLASGSADGTVRLWDLATGE---------------LLRTLTGHSGGVNSVAFSPDGKLLASgSDDGTVRLWDLATG--- 320

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 294 npipsspiskspvsksesssspkdenehSVSLVYKGHKNceTVKGVNfFGPRSEYVVSGSDCGRIFIWRKKGGELIRVME 373
Cdd:COG2319   321 ----------------------------KLLRTLTGHTG--AVRSVA-FSPDGKTLASGSDDGTVRLWDLATGELLRTLT 369

                         330       340       350
                  ....*....|....*....|....*....|
gi 1063726921 374 ADRHVVNCIEPHPHIPVLASSGIESDIKVW 403
Cdd:COG2319   370 GHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
40-276 5.68e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.20  E-value: 5.68e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921  40 SASENLVLRL------EIYKKLEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWDWQLGNVKLSFHsGHANNVFQAKFMPf 113
Cdd:COG2319   179 SGSDDGTVRLwdlatgKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT-GHSGSVRSVAFSP- 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 114 sDDRTIVTCAADGMVRRASILEGDKVETsfLGLHQGRAHKLCIEPGNPHIFyTCGEDGLVQRFDLRTEAPTELFTCRSVD 193
Cdd:COG2319   257 -DGRLLASGSADGTVRLWDLATGELLRT--LTGHSGGVNSVAFSPDGKLLA-SGSDDGTVRLWDLATGKLLRTLTGHTGA 332

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 194 PRrrnmdaiqlnAIAIDPrNSNLFAVGGMEEYARLYDIRRFQgeglngftraadhfCPPHLIGNEDvGITGLAFSEQSEL 273
Cdd:COG2319   333 VR----------SVAFSP-DGKTLASGSDDGTVRLWDLATGE--------------LLRTLTGHTG-AVTSVAFSPDGRT 386


                  ...
gi 1063726921 274 LVS 276
Cdd:COG2319   387 LAS 389
WD40 COG2319
WD40 repeat [General function prediction only];
5-403 6.01e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.20  E-value: 6.01e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921   5 ARRGRSNFNGLHHPVVDFWRREVGGISSRNFSNRFSASENLVLRLEIYKKLEKHKGCVNTVSFNAEGDVLISGSDDRRVV 84
Cdd:COG2319    24 ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVR 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921  85 LWDWQLGNVKLSFHsGHANNVFQAKFMPfsDDRTIVTCAADGMVRRASILEGDKVETsfLGLHQGRAHKLCIEPGNpHIF 164
Cdd:COG2319   104 LWDLATGLLLRTLT-GHTGAVRSVAFSP--DGKTLASGSADGTVRLWDLATGKLLRT--LTGHSGAVTSVAFSPDG-KLL 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 165 YTCGEDGLVQRFDLRTEAPTELFTCRSvdprrrnmDAIqlNAIAIDPrNSNLFAVGGMEEYARLYDIRRFQgeglngftr 244
Cdd:COG2319   178 ASGSDDGTVRLWDLATGKLLRTLTGHT--------GAV--RSVAFSP-DGKLLASGSADGTVRLWDLATGK--------- 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 245 aadhfcPPHLIGNEDVGITGLAFSEQSELLVS-YNDEFIYLF--TPGMGLGSNPIPSSPIskspvsksesssspkdeneH 321
Cdd:COG2319   238 ------LLRTLTGHSGSVRSVAFSPDGRLLASgSADGTVRLWdlATGELLRTLTGHSGGV-------------------N 292

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 322 SVSlvykghkncetvkgvnfFGPRSEYVVSGSDCGRIFIWRKKGGELIRVMEADRHVVNCIEPHPHIPVLASSGIESDIK 401
Cdd:COG2319   293 SVA-----------------FSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVR 355


                  ..
gi 1063726921 402 VW 403
Cdd:COG2319   356 LW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 55-403 2.53e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.46  E-value: 2.53e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921  55 LEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWDWQLGNVKLSFhSGHANNVfqAKFMPFSDDRTIVTCAADGMVRRASiL 134
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPV--RDVAASADGTYLASGSSDKTIRLWD-L 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 135 EGDKVETSFLGlHQGRAHKLCIEPgNPHIFYTCGEDGLVQRFDLRTEAPTELFTCRSvdprrrnmDAIqlNAIAIDPrnS 214
Cdd:cd00200    81 ETGECVRTLTG-HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHT--------DWV--NSVAFSP--D 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 215 NLFAVGGMEE-YARLYDIRRFQGEGLngftraadhfcpphLIGNEDvGITGLAFSEQ-SELLVSYNDEFIYLFTPGMGlg 292
Cdd:cd00200   147 GTFVASSSQDgTIKLWDLRTGKCVAT--------------LTGHTG-EVNSVAFSPDgEKLLSSSSDGTIKLWDLSTG-- 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 293 snpipsspiskspvsksesssspkdenehSVSLVYKGHKNcetvkGVNF--FGPRSEYVVSGSDCGRIFIWRKKGGELIR 370
Cdd:cd00200   210 -----------------------------KCLGTLRGHEN-----GVNSvaFSPDGYLLASGSEDGTIRVWDLRTGECVQ 255

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1063726921 371 VMEADRHVVNCIEPHPHIPVLASSGIESDIKVW 403
Cdd:cd00200   256 TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 26-285 1.33e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.15  E-value: 1.33e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921  26 EVGGISSRNFSNR-FSASENLVLRL------EIYKKLEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWDWQLGNVKLSFH 98
Cdd:cd00200    53 PVRDVAASADGTYlASGSSDKTIRLwdletgECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLR 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921  99 sGHANNVFQAKFMPfsDDRTIVTCAADGMVRrasI--LEGDKVETSFLGlHQGRAHKLCIEPGNPHIFyTCGEDGLVQRF 176
Cdd:cd00200   133 -GHTDWVNSVAFSP--DGTFVASSSQDGTIK---LwdLRTGKCVATLTG-HTGEVNSVAFSPDGEKLL-SSSSDGTIKLW 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 177 DLRTEAPTELFTCRSVdprrrnmdaiQLNAIAIDPrNSNLFAVGGMEEYARLYDIRRFQgeglngftraadhfCPPHLIG 256
Cdd:cd00200   205 DLSTGKCLGTLRGHEN----------GVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGE--------------CVQTLSG 259

                         250       260       270
                  ....*....|....*....|....*....|
gi 1063726921 257 NEDvGITGLAFSEQSELLVS-YNDEFIYLF 285
Cdd:cd00200   260 HTN-SVTSLAWSPDGKRLASgSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 50-280 1.44e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.29  E-value: 1.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921  50 EIYKKLEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWDWQLGNVKLSFHsGHANNVFQAKFMPfsDDRTIVTCAADGMVR 129
Cdd:cd00200    42 ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLT-GHTSYVSSVAFSP--DGRILSSSSRDKTIK 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 130 RASILEGdKVETSFLGlHQGRAHKLCIEPGNPHIFyTCGEDGLVQRFDLRTEAPTELFTCRSVDprrrnmdaiqLNAIAI 209
Cdd:cd00200   119 VWDVETG-KCLTTLRG-HTDWVNSVAFSPDGTFVA-SSSQDGTIKLWDLRTGKCVATLTGHTGE----------VNSVAF 185

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063726921 210 DPrNSNLFAVGGMEEYARLYDIRRFQGEGLngftraadhfcpphLIGNEDvGITGLAFSEQSELLVSYNDE 280
Cdd:cd00200   186 SP-DGEKLLSSSSDGTIKLWDLSTGKCLGT--------------LRGHEN-GVNSVAFSPDGYLLASGSED 240
WD40 COG2319
WD40 repeat [General function prediction only];
40-129 5.87e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.55  E-value: 5.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921  40 SASENLVLRL------EIYKKLEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWDWQLGNVKLSFhSGHANNVFQAKFMPf 113
Cdd:COG2319   305 SGSDDGTVRLwdlatgKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL-TGHTGAVTSVAFSP- 382

                          90
                  ....*....|....*.
gi 1063726921 114 sDDRTIVTCAADGMVR 129
Cdd:COG2319   383 -DGRTLASGSADGTVR 397
WD40 COG2319
WD40 repeat [General function prediction only];
66-403 1.14e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.31  E-value: 1.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921  66 SFNAEGDVLISGSDDRRVVLWDWQLGNVKLSFHSGHANNVFQAkfmPFSDDRTIVTCAADGMVRRASILEGDKVETsfLG 145
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLA---ASPDGARLAAGAGDLTLLLLDAAAGALLAT--LL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 146 LHQGRAHKLCIEPGNPHIfYTCGEDGLVQRFDLRTEAPTELFTCRSvdprrrnmDAIqlNAIAIDPrNSNLFAVGGMEEY 225
Cdd:COG2319    76 GHTAAVLSVAFSPDGRLL-ASASADGTVRLWDLATGLLLRTLTGHT--------GAV--RSVAFSP-DGKTLASGSADGT 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 226 ARLYDirrfqgeglngftrAADHFCPPHLIGNEDvGITGLAFSEQSELLVS-YNDEFIYLFtpgmglgsnpipsspisks 304
Cdd:COG2319   144 VRLWD--------------LATGKLLRTLTGHSG-AVTSVAFSPDGKLLASgSDDGTVRLW------------------- 189

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 305 pvsksesssspkDENEHSVSLVYKGHKNceTVKGVNFfGPRSEYVVSGSDCGRIFIWRKKGGELIRVMEADRHVVNCIEP 384
Cdd:COG2319   190 ------------DLATGKLLRTLTGHTG--AVRSVAF-SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF 254

                         330
                  ....*....|....*....
gi 1063726921 385 HPHIPVLASSGIESDIKVW 403
Cdd:COG2319   255 SPDGRLLASGSADGTVRLW 273
WD40 pfam00400
WD domain, G-beta repeat;
50-87 3.89e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 3.89e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1063726921  50 EIYKKLEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWD 87
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 53-87 4.48e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 4.48e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1063726921   53 KKLEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWD 87
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
40-89 3.46e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 3.46e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1063726921  40 SASENLVLRL------EIYKKLEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWDWQ 89
Cdd:COG2319   347 SGSDDGTVRLwdlatgELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 326-403 1.16e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.25  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 326 VYKGHKncetvKGVNF--FGPRSEYVVSGSDCGRIFIWRKKGGELIRVMEADRHVVNCIEPHPHIPVLASSGIESDIKVW 403
Cdd:cd00200     4 TLKGHT-----GGVTCvaFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW 78
WD40 COG2319
WD40 repeat [General function prediction only];
326-414 1.50e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.13  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063726921 326 VYKGHKNceTVKGVNFFgPRSEYVVSGSDCGRIFIWRKKGGELIRVMEADRHVVNCIEPHPHIPVLASSGIESDIKVW-T 404
Cdd:COG2319   157 TLTGHSG--AVTSVAFS-PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWdL 233

                          90
                  ....*....|
gi 1063726921 405 SKAAERATLP 414
Cdd:COG2319   234 ATGKLLRTLT 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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