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Conserved domains on  [gi|1063735663|ref|NP_001330667|]
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SET domain protein 25 [Arabidopsis thaliana]

Protein Classification

SET domain-containing protein( domain architecture ID 14442795)

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones

CATH:  2.170.270.10
EC:  2.1.1.-
Gene Ontology:  GO:0005515|GO:0008168|GO:1904047
PubMed:  12372294|17013555|16086857

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 1237-1384 3.71e-100

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


:

Pssm-ID: 380946  Cd Length: 148  Bit Score: 315.82  E-value: 3.71e-100
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1237 DVLKMSQLKARKKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDA 1316
Cdd:cd19169      1 DLLKFNQLKFRKKQLKFAKSRIHDWGLFALEPIAADEMVIEYVGQVIRQSVADEREKRYEAIGIGSSYLFRVDDDTIIDA 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063735663 1317 TKRGGIARFINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDDKIPCNCGAPKCR 1384
Cdd:cd19169     81 TKCGNLARFINHSCNPNCYAKIITVESQKKIVIYSKRPIAVNEEITYDYKFPIEDEKIPCLCGAPQCR 148
 
Name Accession Description Interval E-value
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 1237-1384 3.71e-100

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


Pssm-ID: 380946  Cd Length: 148  Bit Score: 315.82  E-value: 3.71e-100
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1237 DVLKMSQLKARKKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDA 1316
Cdd:cd19169      1 DLLKFNQLKFRKKQLKFAKSRIHDWGLFALEPIAADEMVIEYVGQVIRQSVADEREKRYEAIGIGSSYLFRVDDDTIIDA 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063735663 1317 TKRGGIARFINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDDKIPCNCGAPKCR 1384
Cdd:cd19169     81 TKCGNLARFINHSCNPNCYAKIITVESQKKIVIYSKRPIAVNEEITYDYKFPIEDEKIPCLCGAPQCR 148
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 1249-1372 5.68e-43

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 152.87  E-value: 5.68e-43
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663  1249 KHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDATKRGGIARFINH 1328
Cdd:smart00317    1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYDTDGAKAFYLFDIDSDLCIDARRKGNLARFINH 80

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 1063735663  1329 SCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDD 1372
Cdd:smart00317   81 SCEPNCELLFVEVNGDDRIVIFALRDIKPGEELTIDYGSDYANE 124
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
1241-1385 1.74e-38

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 140.10  E-value: 1.74e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1241 MSQLKarkKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIrsSISEIRERqYEKMGIGSSYLFRLDDGYVLDATKRG 1320
Cdd:COG2940      1 MAMLH---PRIEVRPSPIHGRGVFATRDIPKGTLIGEYPGEVI--TWAEAERR-EPHKEPLHTYLFELDDDGVIDGALGG 74

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063735663 1321 GIARFINHSCEPNCYTkiisVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDDKIPCNCgaPKCRG 1385
Cdd:COG2940     75 NPARFINHSCDPNCEA----DEEDGRIFIVALRDIAAGEELTYDYGLDYDEEEYPCRC--PNCRG 133
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 1261-1366 7.82e-31

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 117.62  E-value: 7.82e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1261 WGLVALEPIEAEDFVIEYVGE-LIRSSISEIRERQYEKMGIG---SSYLFRLDD--GYVLDAT--KRGGIARFINHSCEP 1332
Cdd:pfam00856    2 RGLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYYDKLELrlwGPYLFTLDEdsEYCIDARalYYGNWARFINHSCDP 81

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1063735663 1333 NCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYK 1366
Cdd:pfam00856   82 NCEVRVVYVNGGPRIVIFALRDIKPGEELTIDYG 115
 
Name Accession Description Interval E-value
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 1237-1384 3.71e-100

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


Pssm-ID: 380946  Cd Length: 148  Bit Score: 315.82  E-value: 3.71e-100
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1237 DVLKMSQLKARKKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDA 1316
Cdd:cd19169      1 DLLKFNQLKFRKKQLKFAKSRIHDWGLFALEPIAADEMVIEYVGQVIRQSVADEREKRYEAIGIGSSYLFRVDDDTIIDA 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063735663 1317 TKRGGIARFINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDDKIPCNCGAPKCR 1384
Cdd:cd19169     81 TKCGNLARFINHSCNPNCYAKIITVESQKKIVIYSKRPIAVNEEITYDYKFPIEDEKIPCLCGAPQCR 148
SET_SET1 cd20072
SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...
 1237-1384 6.59e-76

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).


Pssm-ID: 380998  Cd Length: 148  Bit Score: 247.72  E-value: 6.59e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1237 DVLKMSQLKARKKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDA 1316
Cdd:cd20072      1 DLLRFNQLKKRKKQLKFARSAIHNWGLYAMENISAKDMVIEYVGEVIRQQVADEREKRYLRQGIGSSYLFRIDDDTVVDA 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063735663 1317 TKRGGIARFINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDDKIPCNCGAPKCR 1384
Cdd:cd20072     81 TKKGNIARFINHCCDPNCTAKIIKVEGEKRIVIYAKRDIAAGEELTYDYKFPREEDKIPCLCGAPNCR 148
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 1239-1384 1.42e-75

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 247.13  E-value: 1.42e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1239 LKMSQLKARKKH-LRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDAT 1317
Cdd:cd10518      3 KRFRQLRSRLKErLRVGKSGIHGWGLFAKRPIAAGEMVIEYVGEVIRPIVADKREKRYDEEGGGGTYMFRIDEDLVIDAT 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063735663 1318 KRGGIARFINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDD-KIPCNCGAPKCR 1384
Cdd:cd10518     83 KKGNIARFINHSCDPNCYAKIITVDGEKHIVIFAKRDIAPGEELTYDYKFPIEDEeKIPCLCGAPNCR 150
SET_SETD1A cd19204
SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and ...
 1236-1388 4.32e-67

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and similar proteins; SETD1A (EC2.1.1.43), also termed lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit SET1, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Human SET domain containing protein 1A (hSETD1A) expression occurs at a high rate in hepatocellular carcinoma patients and controls tumor metastasis in breast cancer by activating MMP expression.


Pssm-ID: 380981 [Multi-domain]  Cd Length: 153  Bit Score: 222.98  E-value: 4.32e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1236 ADVLKMSQLKARKKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLD 1315
Cdd:cd19204      1 SDLLKLNQLKFRKKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNIRQVVADMREKRYVQEGIGSSYLFRVDHDTIID 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063735663 1316 ATKRGGIARFINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDDKIPCNCGAPKCRGSLN 1388
Cdd:cd19204     81 ATKCGNLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVNEEITYDYKFPIEDNKIPCLCGTENCRGTLN 153
SET_SETD1B cd19205
SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and ...
 1236-1388 1.54e-62

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and similar proteins; SETD1B (EC2.1.1.43), also termed lysine N-methyltransferase 2G, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Loss of SETD1B occurs in up to half the gastric and colorectal cancers, most commonly via SETD1B mutations, while de novo variants in SETD1B are associated with intellectual disability, epilepsy and autism.


Pssm-ID: 380982 [Multi-domain]  Cd Length: 153  Bit Score: 209.91  E-value: 1.54e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1236 ADVLKMSQLKARKKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLD 1315
Cdd:cd19205      1 SDLLKFNQLKFRKKKLKFCKSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIID 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063735663 1316 ATKRGGIARFINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDDKIPCNCGAPKCRGSLN 1388
Cdd:cd19205     81 ATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSKQHINVNEEITYDYKFPIEDVKIPCLCGSENCRGTLN 153
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 1247-1388 1.99e-61

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 206.47  E-value: 1.99e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1247 RKKHLR--------FQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSsYLFRLDDGYVLDATK 1318
Cdd:cd19170      4 RFRHLRktakeavgVYRSPIHGRGLFCKRNIDAGEMVIEYAGEVIRSVLTDKREKYYESKGIGC-YMFRIDDDEVVDATM 82

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1319 RGGIARFINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDDKIPCNCGAPKCRGSLN 1388
Cdd:cd19170     83 HGNAARFINHSCEPNCYSRVVNIDGKKHIVIFALRRILRGEELTYDYKFPIEDVKIPCTCGSKKCRKYLN 152
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 1240-1385 8.51e-53

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 181.86  E-value: 8.51e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1240 KMSQLKARKKHLR----FQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSsYLFRLDDGYVLD 1315
Cdd:cd19171      1 KSSQYRKLKTEWRsnvyLARSRIQGLGLYAARDIEKHTMVIEYIGEIIRNEVANRREKIYESQNRGI-YMFRIDNDWVID 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063735663 1316 ATKRGGIARFINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDD--KIPCNCGAPKCRG 1385
Cdd:cd19171     80 ATMTGGPARYINHSCNPNCVAEVVTFDKEKKIIIISNRRIAKGEELTYDYKFDFEDDqhKIPCLCGAPNCRK 151
SET_KMT2A cd19206
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...
 1245-1388 6.97e-47

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).


Pssm-ID: 380983 [Multi-domain]  Cd Length: 154  Bit Score: 165.20  E-value: 6.97e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1245 KARKKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSsYLFRLDDGYVLDATKRGGIAR 1324
Cdd:cd19206     10 KTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYSGNVIRSILTDKREKYYDSKGIGC-YMFRIDDSEVVDATMHGNAAR 88

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063735663 1325 FINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLED--DKIPCNCGAPKCRGSLN 1388
Cdd:cd19206     89 FINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDasNKLPCNCGAKKCRKFLN 154
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 1249-1372 5.68e-43

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 152.87  E-value: 5.68e-43
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663  1249 KHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDATKRGGIARFINH 1328
Cdd:smart00317    1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYDTDGAKAFYLFDIDSDLCIDARRKGNLARFINH 80

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 1063735663  1329 SCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDD 1372
Cdd:smart00317   81 SCEPNCELLFVEVNGDDRIVIFALRDIKPGEELTIDYGSDYANE 124
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 1249-1365 1.79e-42

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 150.86  E-value: 1.79e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1249 KHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGigSSYLFRLDDGYVLDATKRGGIARFINH 1328
Cdd:cd10519      1 KRLLLGKSDVAGWGLFLKEPIKKDEFIGEYTGELISQDEADRRGKIYDKYN--SSYLFNLNDQFVVDATRKGNKIRFANH 78

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1063735663 1329 SCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNY 1365
Cdd:cd10519     79 SSNPNCYAKVMMVNGDHRIGIFAKRDIEAGEELFFDY 115
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 1261-1384 1.85e-42

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 151.64  E-value: 1.85e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1261 WGLVALEPIEAEDFVIEYVGELIrsSISEIRER--QYEKMGIGSSYLFRLDDGYVLDATKRGGIARFINHSCEPNCYTKI 1338
Cdd:cd10531     12 WGVKAKEDIQKGEFIIEYVGEVI--DKKEFKERldEYEELGKSNFYILSLSDDVVIDATRKGNLSRFINHSCEPNCETQK 89

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1063735663 1339 ISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDD-KIPCNCGAPKCR 1384
Cdd:cd10531     90 WIVNGEYRIGIFALRDIPAGEELTFDYNFVNYNEaKQVCLCGAQNCR 136
SET_KMT2B cd19207
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...
 1245-1388 2.71e-41

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.


Pssm-ID: 380984 [Multi-domain]  Cd Length: 154  Bit Score: 149.02  E-value: 2.71e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1245 KARKKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSsYLFRLDDGYVLDATKRGGIAR 1324
Cdd:cd19207     10 KTSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDSKGIGC-YMFRIDDFDVVDATMHGNAAR 88

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063735663 1325 FINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLED--DKIPCNCGAPKCRGSLN 1388
Cdd:cd19207     89 FINHSCEPNCYSRVIHVEGQKHIVIFALRKIYRGEELTYDYKFPIEDasNKLPCNCGAKRCRRFLN 154
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 1261-1385 1.94e-40

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 146.19  E-value: 1.94e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1261 WGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDATKRGGIARFINHSCEPNCYTKIIS 1340
Cdd:cd19172     14 WGLRAAEDLPKGTFVIEYVGEVLDEKEFKRRMKEYAREGNRHYYFMALKSDEIIDATKKGNLSRFINHSCEPNCETQKWT 93

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1063735663 1341 VEGKKKIFIYAKRHIDAGEEISYNYKFPL-EDDKIPCNCGAPKCRG 1385
Cdd:cd19172     94 VNGELRVGFFAKRDIPAGEELTFDYQFERyGKEAQKCYCGSPNCRG 139
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
1241-1385 1.74e-38

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 140.10  E-value: 1.74e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1241 MSQLKarkKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIrsSISEIRERqYEKMGIGSSYLFRLDDGYVLDATKRG 1320
Cdd:COG2940      1 MAMLH---PRIEVRPSPIHGRGVFATRDIPKGTLIGEYPGEVI--TWAEAERR-EPHKEPLHTYLFELDDDGVIDGALGG 74

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063735663 1321 GIARFINHSCEPNCYTkiisVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDDKIPCNCgaPKCRG 1385
Cdd:COG2940     75 NPARFINHSCDPNCEA----DEEDGRIFIVALRDIAAGEELTYDYGLDYDEEEYPCRC--PNCRG 133
SET_KMT2C cd19208
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) ...
 1248-1384 2.24e-37

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) and similar proteins; KMT2C (EC2.1.1.43; also termed lysine N-methyltransferase 2C, homologous to ALR protein (HALR) myeloid/lymphoid, or mixed-lineage leukemia protein 3 (MLL3)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) and may be involved in leukemogenesis and developmental disorder. KMT2C is a catalytic subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. Overexpression of KMT2C is associated with estrogen receptor-positive breast cancer; KMT2C mediates the estrogen dependence of breast cancer through regulation of estrogen receptor alpha (ERalpha) enhancer function. KMT2C is frequently mutated in certain populations with diffuse-type gastric adenocarcinomas (DGA); its loss promotes epithelial-to-mesenchymal transition (EMT) and is associated with worse overall survival.


Pssm-ID: 380985 [Multi-domain]  Cd Length: 154  Bit Score: 137.84  E-value: 2.24e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1248 KKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSsYLFRLDDGYVLDATKRGGIARFIN 1327
Cdd:cd19208     14 KSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGV-YMFRIDNDHVIDATLTGGPARYIN 92

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063735663 1328 HSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDD--KIPCNCGAPKCR 1384
Cdd:cd19208     93 HSCAPNCVAEVVTFEKGHKIIISSSRRIQKGEELCYDYKFDFEDDqhKIPCHCGAVNCR 151
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 1261-1385 6.51e-37

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 135.88  E-value: 6.51e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1261 WGLVALEPIEAEDFVIEYVGELIrsSISEIRER---QYEKMGigSSYLFRLDDGYVLDATKRGGIARFINHSCEPNCYTK 1337
Cdd:cd19174     12 WGVRTKEPIKAGQFIIEYVGEVV--SEQEFRRRmieQYHNHS--HHYCLNLDSGMVIDGYRMGNEARFVNHSCDPNCEMQ 87

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1338 IISVEGKKKIFIYAKRHIDAGEEISYNYKFPL--EDDKIPCNCGAPKCRG 1385
Cdd:cd19174     88 KWSVNGVYRIGLFALKDIPAGEELTYDYNFHSfnVEKQQPCKCGSPNCRG 137
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 1261-1387 5.11e-36

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 133.31  E-value: 5.11e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1261 WGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDATKRGGIARFINHSCEPNCYTKIIS 1340
Cdd:cd19175     12 WGLVADEDINAGEFIIEYVGEVIDDKTCEERLWDMKHKGEKNFYMCEIDKDMVIDATFKGNLSRFINHSCDPNCELQKWQ 91

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1063735663 1341 VEGKKKIFIYAKRHIDAGEEISYNYKFPLEDDKIPCNCGAPKCRGSL 1387
Cdd:cd19175     92 VDGETRIGVFAIRDIKKGEELTYDYQFVQFGADQDCHCGSKNCRGKL 138
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 1261-1387 1.01e-34

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 129.74  E-value: 1.01e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1261 WGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDATKRGGIARFINHSCEPNCYTKIIS 1340
Cdd:cd19173     14 WGLRTKRDIKKGDFVIEYVGELIDEEECRRRLKKAHENNITNFYMLTLDKDRIIDAGPKGNLSRFMNHSCQPNCETQKWT 93

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1063735663 1341 VEGKKKIFIYAKRHIDAGEEISYNYKFP-LEDDKIPCNCGAPKCRGSL 1387
Cdd:cd19173     94 VNGDTRVGLFAVRDIPAGEELTFNYNLDcLGNEKKVCRCGAPNCSGFL 141
SET_KMT2D cd19209
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) ...
 1248-1384 2.12e-33

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins; KMT2D (EC2.1.1.43; also termed lysine N-methyltransferase 2D, ALL1-related protein (ALR), or myeloid/lymphoid or mixed-lineage leukemia protein 2 (MLL2)), acts as histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. KMT2D is a subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380986 [Multi-domain]  Cd Length: 155  Bit Score: 126.73  E-value: 2.12e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1248 KKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSsYLFRLDDGYVLDATKRGGIARFIN 1327
Cdd:cd19209     15 KNNVYLARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGI-YMFRINNEHVIDATLTGGPARYIN 93

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063735663 1328 HSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDDK--IPCNCGAPKCR 1384
Cdd:cd19209     94 HSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQFDFEDDQhkIPCHCGAWNCR 152
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 1261-1366 7.82e-31

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 117.62  E-value: 7.82e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1261 WGLVALEPIEAEDFVIEYVGE-LIRSSISEIRERQYEKMGIG---SSYLFRLDD--GYVLDAT--KRGGIARFINHSCEP 1332
Cdd:pfam00856    2 RGLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYYDKLELrlwGPYLFTLDEdsEYCIDARalYYGNWARFINHSCDP 81

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1063735663 1333 NCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYK 1366
Cdd:pfam00856   82 NCEVRVVYVNGGPRIVIFALRDIKPGEELTIDYG 115
SET_NSD2 cd19211
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...
 1261-1387 6.97e-29

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).


Pssm-ID: 380988 [Multi-domain]  Cd Length: 142  Bit Score: 113.16  E-value: 6.97e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1261 WGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDATKRGGIARFINHSCEPNCYTKIIS 1340
Cdd:cd19211     14 WGLIAKRDIKKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETQKWT 93

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1063735663 1341 VEGKKKIFIYAKRHIDAGEEISYNYKFP-LEDDKIPCNCGAPKCRGSL 1387
Cdd:cd19211     94 VNGDTRVGLFAVCDIPAGTELTFNYNLDcLGNEKTVCRCGAPNCSGFL 141
SET_EZH2 cd19218
SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43) ...
 1248-1367 8.64e-29

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380995  Cd Length: 120  Bit Score: 111.93  E-value: 8.64e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1248 KKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGigSSYLFRLDDGYVLDATKRGGIARFIN 1327
Cdd:cd19218      3 KKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYM--CSFLFNLNNDFVVDATRKGNKIRFAN 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1063735663 1328 HSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKF 1367
Cdd:cd19218     81 HSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRY 120
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 1261-1387 5.69e-28

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 113.93  E-value: 5.69e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1261 WGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKmgIGSSYLFRLD-----DGYVLDATKRGGIARFINHSCEPNcy 1335
Cdd:cd10542    100 WGVKTLEDIKKGTFVMEYVGEIITSEEAERRGKIYDA--NGRTYLFDLDyndddCEYTVDAAYYGNISHFINHSCDPN-- 175

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1336 TKIISV------EGKKKIFIYAKRHIDAGEEISYNYKFPLEDD------------KIPCNCGAPKCRGSL 1387
Cdd:cd10542    176 LAVYAVwinhldPRLPRIAFFAKRDIKAGEELTFDYLMTGTGGssestipkpkdvRVPCLCGSKNCRKYL 245
SET_EZH1 cd19217
SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43) ...
 1245-1371 4.21e-27

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380994  Cd Length: 136  Bit Score: 107.85  E-value: 4.21e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1245 KARKKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGigSSYLFRLDDGYVLDATKRGGIAR 1324
Cdd:cd19217      2 RGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYM--SSFLFNLNNDFVVDATRKGNKIR 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1063735663 1325 FINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLED 1371
Cdd:cd19217     80 FANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQQGEELFFDYRYSQAD 126
SET_NSD1 cd19210
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 1261-1387 2.90e-26

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.


Pssm-ID: 380987 [Multi-domain]  Cd Length: 142  Bit Score: 105.78  E-value: 2.90e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1261 WGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDATKRGGIARFINHSCEPNCYTKIIS 1340
Cdd:cd19210     14 WGLRCKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWT 93

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1063735663 1341 VEGKKKIFIYAKRHIDAGEEISYNYKFP-LEDDKIPCNCGAPKCRGSL 1387
Cdd:cd19210     94 VNGDTRVGLFALCDIKAGTELTFNYNLEcLGNGKTVCKCGAPNCSGFL 141
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 1244-1365 6.15e-24

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 101.68  E-value: 6.15e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1244 LKARKKHLRFQQSKIHD--WGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGigSSYLFRLDD---------GY 1312
Cdd:cd10538     82 VVQRGLQARLQVFRTSKkgWGVRSLEFIPKGSFVCEYVGEVITTSEADRRGKIYDKSG--GSYLFDLDEfsdsdgdgeEL 159

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063735663 1313 VLDATKRGGIARFINHSCEPNCYTKIISVEGKK----KIFIYAKRHIDAGEEISYNY 1365
Cdd:cd10538    160 CVDATFCGNVSRFINHSCDPNLFPFNVVIDHDDlrypRIALFATRDILPGEELTFDY 216
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 1262-1367 1.01e-23

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 97.80  E-value: 1.01e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1262 GLVALEPIEAEDFVIEYVGELIRSSISEirerQYEKMGIGSSYLFRLD-DGYVLDATKRGGIARFINHSCEPNCYTKIIS 1340
Cdd:cd10522     16 GLFAAETIAKGEFVGEYTGEVLDRWEED----RDSVYHYDPLYPFDLNgDILVIDAGKKGNLTRFINHSDQPNLELIVRT 91

                           90       100
                   ....*....|....*....|....*....
gi 1063735663 1341 VEGKKKIFIYAKRHIDAGEE--ISYNYKF 1367
Cdd:cd10522     92 LKGEQHIGFVAIRDIKPGEElfISYGPKY 120
SET_NSD3 cd19212
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 1261-1387 1.95e-23

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins; NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. NSD3 is amplified and overexpressed in multiple cancer types, including acute myeloid leukemia (AML), breast, lung, pancreatic and bladder cancers, as well as squamous cell carcinoma of the head and neck (SCCHN). NSD3 contributes to tumorigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukemia (AML). NSD3 is amplified in primary tumors and cell lines from breast carcinoma, and can promote the cell viability of small-cell lung cancer and pancreatic ductal adenocarcinoma. High NSD3 expression is implicated in poor grade and heavy smoking history in SCCHN. Thus, NSD3 may serve as a potential druggable target for selective cancer therapy.


Pssm-ID: 380989 [Multi-domain]  Cd Length: 142  Bit Score: 97.69  E-value: 1.95e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1261 WGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDATKRGGIARFINHSCEPNCYTKIIS 1340
Cdd:cd19212     14 WGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWT 93

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1063735663 1341 VEGKKKIFIYAKRHIDAGEEISYNYKFP-LEDDKIPCNCGAPKCRGSL 1387
Cdd:cd19212     94 VNGDVRVGLFALCDIPAGMELTFNYNLDcLGNGRTECHCGADNCSGFL 141
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 1261-1387 2.19e-23

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 100.84  E-value: 2.19e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1261 WGLVALEPIEAEDFVIEYVGELIrsSISEIRERQYEKMGIGSSYLF----RLDDGYVL----DATKRGGIARFINHSCEP 1332
Cdd:cd10544    102 WGLRTLEFIPKGRFVCEYAGEVI--GFEEARRRTKSQTKGDMNYIIvlreHLSSGKVLetfvDPTYIGNIGRFLNHSCEP 179

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063735663 1333 NCYTKIISVEGK-KKIFIYAKRHIDAGEEISYNY---------------KFPLEDDKiPCNCGAPKCRGSL 1387
Cdd:cd10544    180 NLFMVPVRVDSMvPKLALFAARDIVAGEELSFDYsgefsnsvesvtlarQDESKSRK-PCLCGAENCRGFL 249
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 1261-1386 4.13e-23

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 99.72  E-value: 4.13e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1261 WGLVALEPIEAEDFVIEYVGELIRSSISEIRErqyekmgiGSSYLFRLD----DGYVLDATKRGGIARFINHSCEPNcyt 1336
Cdd:cd10543    103 WGVRALQDIPKGTFVCEYIGELISDSEADSRE--------DDSYLFDLDnkdgETYCIDARRYGNISRFINHLCEPN--- 171

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063735663 1337 kIISVegkkKIFI------------YAKRHIDAGEEISYNY--KF-PLEDDKIPCNCGAPKCRGS 1386
Cdd:cd10543    172 -LIPV----RVFVehqdlrfpriafFASRDIKAGEELGFDYgeKFwRIKGKYFTCRCGSPKCKYS 231
SET_EHMT1 cd10535
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 1244-1386 1.67e-22

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380933 [Multi-domain]  Cd Length: 231  Bit Score: 97.70  E-value: 1.67e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1244 LKARkkhLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERqyekmgigSSYLFRLD--DG--YVLDATKR 1319
Cdd:cd10535     89 LRAR---LQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREE--------DSYLFDLDnkDGevYCIDARFY 157

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063735663 1320 GGIARFINHSCEPNCYTKIISVEGKK----KIFIYAKRHIDAGEEISYNYKFPLEDDK---IPCNCGAPKCRGS 1386
Cdd:cd10535    158 GNVSRFINHHCEPNLVPVRVFMAHQDlrfpRIAFFSTRLIEAGEQLGFDYGERFWDIKgklFSCRCGSPKCRHS 231
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 1262-1365 3.10e-22

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 94.18  E-value: 3.10e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1262 GLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDG---YVLDATKR-GGIARFINHSC-EPNCYT 1336
Cdd:cd10528     30 GVIATRPFEKGDFVVEYHGDLITITEAKKREALYAKDPSTGCYMYYFQYKgktYCVDATKEsGRLGRLINHSKkKPNLKT 109

                           90       100
                   ....*....|....*....|....*....
gi 1063735663 1337 KIISVEGKKKIFIYAKRHIDAGEEISYNY 1365
Cdd:cd10528    110 KLLVIDGVPHLILVAKRDIKPGEELLYDY 138
SET_EZH-like cd19168
SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...
 1249-1365 4.03e-22

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380945  Cd Length: 124  Bit Score: 93.02  E-value: 4.03e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1249 KHLRFQQSKIHD-WGLVALEPIEAEDFVIEYVGELIrsSISEIRERQYEKMGIGSSYLFRLDDGYVLDATKRGGIARFIN 1327
Cdd:cd19168      1 KAVVLGKSQLECgLGLFAAEDIKEGEFVIEYTGELI--SHDEGVRREHRRGDVSYLYLFEEQEGIWVDAAIYGNLSRYIN 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1063735663 1328 HSCEP----NCYTKIISVEGKKKIFIYAKRHIDAGEEISYNY 1365
Cdd:cd19168     79 HATDKvktgNCMPKIMYVNHEWRIKFTAIKDIKIGEELFFNY 120
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 1253-1387 1.08e-21

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 96.12  E-value: 1.08e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1253 FQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMgiGSSYLFRLD---DGYVLDATKRGGIARFINHS 1329
Cdd:cd10525     91 FRTDNGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQ--GATYLFDLDyveDVYTVDAAYYGNISHFVNHS 168

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1330 CEPN--CYTKIISV--EGKKKIFIYAKRHIDAGEEISYNYKF------------------------PLEDDKIPCNCGAP 1381
Cdd:cd10525    169 CDPNlqVYNVFIDNldERLPRIALFATRTIRAGEELTFDYNMqvdpvdaestkmdsnfglaglpgsPKKRVRIECKCGVR 248


                   ....*.
gi 1063735663 1382 KCRGSL 1387
Cdd:cd10525    249 SCRKYL 254
SET_SUV39H2 cd10532
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 1253-1387 1.49e-21

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380930 [Multi-domain]  Cd Length: 243  Bit Score: 95.34  E-value: 1.49e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1253 FQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIgsSYLFRLD---DGYVLDATKRGGIARFINHS 1329
Cdd:cd10532     89 FRTSNGRGWGVKTLQKIKKNSFVMEYVGEVITSEEAERRGQFYDSKGI--TYLFDLDyesDEFTVDAARYGNVSHFVNHS 166

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063735663 1330 CEPNCYTKIISVEGKK----KIFIYAKRHIDAGEEISYNYKFPLEDD---------------KIPCNCGAPKCRGSL 1387
Cdd:cd10532    167 CDPNLQVFNVFIDNLDtrlpRIALFSTRTIKAGEELTFDYQMKGSGDlssdsidnspakkrvRTVCKCGAVTCRGYL 243
SET_SUV39H_Clr4-like cd20073
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...
 1245-1387 3.10e-19

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.


Pssm-ID: 380999 [Multi-domain]  Cd Length: 259  Bit Score: 89.17  E-value: 3.10e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1245 KARKKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIgsSYLFRLD-------DGYVLDAT 1317
Cdd:cd20073     89 RGRKLPLEIFKTKHKGWGLRCPRFIKAGTFIGVYLGEVITQSEAEIRGKKYDNVGV--TYLFDLDlfedqvdEYYTVDAQ 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1318 KRGGIARFINHSCEPNCYTKIISVE-GKKKIF---IYAKRHIDAGEEISYNYKFPLEDD------------------KIP 1375
Cdd:cd20073    167 YCGDVTRFINHSCDPNLAIYSVLRDkSDSKIYdlaFFAIKDIPALEELTFDYSGRNNFDqlgfignrsnskyinlknKRP 246

                          170
                   ....*....|..
gi 1063735663 1376 CNCGAPKCRGSL 1387
Cdd:cd20073    247 CYCGSANCRGWL 258
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 1261-1387 3.32e-18

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 86.57  E-value: 3.32e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1261 WGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYekmgiGSSYLFRLD---------DG---------YVLDATKRGGI 1322
Cdd:cd10517    141 WGIRCLDDIPKGSFVCIYAGQILTEDEANEEGLQY-----GDEYFAELDyievveklkEGyesdveehcYIIDAKSEGNL 215

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063735663 1323 ARFINHSCEPNCYTKIISVEGKKKIF----IYAKRHIDAGEEISYNYKFPL---EDDKIPCNCGAPKCRGSL 1387
Cdd:cd10517    216 GRYLNHSCSPNLFVQNVFVDTHDLRFpwvaFFASRYIRAGTELTWDYNYEVgsvPGKVLYCYCGSSNCRGRL 287
SET_EHMT2 cd10533
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 1248-1386 3.73e-18

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380931 [Multi-domain]  Cd Length: 239  Bit Score: 85.45  E-value: 3.73e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1248 KKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRErqyekmgiGSSYLFRLD--DG--YVLDATKRGGIA 1323
Cdd:cd10533     90 KVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVRE--------DDSYLFDLDnkDGevYCIDARYYGNIS 161

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1324 RFINHSCEPNCYTKIISVEGKK----KIFIYAKRHIDAGEEISYNYKFPLEDDK---IPCNCGAPKCRGS 1386
Cdd:cd10533    162 RFINHLCDPNIIPVRVFMLHQDlrfpRIAFFSSRDIRTGEELGFDYGDRFWDIKskyFTCQCGSEKCKHS 231
SET_SUV39H_DIM5-like cd19473
SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...
 1253-1387 8.31e-18

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.


Pssm-ID: 380996 [Multi-domain]  Cd Length: 274  Bit Score: 85.06  E-value: 8.31e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1253 FQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLD--------------DGYVLDATK 1318
Cdd:cd19473    110 FRTSDGRGWGVRSTVDIKRGQFVDCYVGEIITPEEAQRRRDAATIAQRKDVYLFALDkfsdpdsldprlrgDPYEIDGEF 189

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1319 RGGIARFINHSCEPNcyTKIISVEG---KKKIF---IYAKRHIDAGEEISYNY------------KFPLEDDKIPCNCGA 1380
Cdd:cd19473    190 MSGPTRFINHSCDPN--LRIFARVGdhaDKHIHdlaFFAIKDIPRGTELTFDYvdgvtgldddagDEEKEKEMTKCLCGS 267


                   ....*..
gi 1063735663 1381 PKCRGSL 1387
Cdd:cd19473    268 PKCRGYL 274
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 1289-1365 4.25e-17

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 76.91  E-value: 4.25e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1289 EIRERQYEKMGIGssyLFrlddgyVLDATKRG---GIARFINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNY 1365
Cdd:cd08161      1 EIRPSTIPGAGFG---LF------ATRDIPKGeviGLARFINHSCEPNCEFEEVYVGGKPRVFIVALRDIKAGEELTVDY 71
SET_SETD5-like cd10529
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...
 1262-1365 5.90e-17

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380927  Cd Length: 127  Bit Score: 78.47  E-value: 5.90e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1262 GLVALEPIEAEDFVIEYVGELirSSISEIRErQYEKMGIGSSYLFrLDDGY-----VLDATKRGGIARFINHSCEPNCYT 1336
Cdd:cd10529     18 GLVATEDISPGEPILEYKGEV--SLRSEFKE-DNGFFKRPSPFVF-FYDGFeglplCVDARKYGNEARFIRRSCRPNAEL 93

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1063735663 1337 KIISVEGKK-KIFIYAKRHIDAGEEI----SYNY 1365
Cdd:cd10529     94 RHVVVSNGElRLFIFALKDIRKGTEItipfDYDY 127
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 1251-1387 7.82e-15

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 76.41  E-value: 7.82e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1251 LRFQQSKIHD--WGLVALEPIEAEDFVIEYVGELIRSSISEI------------RERQYEKMGIGSSYLFRLDDG-YVLD 1315
Cdd:cd10523    108 VRLQVFKTEKkgWGVRCLDDIDKGTFVCIYAGRVLSRARSPTeplppklelpseNEVEVVTSWLILSKKRKLRENvCFLD 187

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063735663 1316 ATKRGGIARFINHSCEPNCYTKIISVEGKKKIF----IYAKRHIDAGEEISYNYKF---PLEDDKIPCNCGAPKCRGSL 1387
Cdd:cd10523    188 ASKEGNVGRFLNHSCCPNLFVQNVFVDTHDKNFpwvaFFTNRVVKAGTELTWDYSYdagTSPEQEIPCLCGVNKCQKKI 266
SET_SETDB cd10541
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...
 1261-1387 1.66e-14

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380939 [Multi-domain]  Cd Length: 236  Bit Score: 74.50  E-value: 1.66e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1261 WGLVALEPIEAEDFVIEYVGELIRSSISEireRQYEKMGigSSYLFRLD----DGYVLDATKRGGIARFINHSCEPNCYT 1336
Cdd:cd10541    104 WGIRCLDDIAKGTFVCIYAGKILTDDFAD---KEGLEMG--DEYFANLDhieeSCYIIDAKLEGNLGRYLNHSCSPNLFV 178

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063735663 1337 KIISVEGKKKIF----IYAKRHIDAGEEISYNYKF---PLEDDKIPCNCGAPKCRGSL 1387
Cdd:cd10541    179 QNVFVDTHDLRFpwvaFFASKRIKAGTELTWDYNYevgSVEGKELLCCCGSNECRGRL 236
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 1238-1365 6.89e-14

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 72.82  E-value: 6.89e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1238 VLKMSQlKARKKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRE-----------RQYEKMGIGSSYLF 1306
Cdd:cd10545     76 YNRVTQ-KGLRYRLEVFKTAERGWGVRSWDSIPAGSFICEYVGELLDTSEADTRSgnddylfdidnRQTNRGWDGGQRLD 154

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063735663 1307 RLDD-------------GYVLDATKRGGIARFINHSCEPNCYTKIISVEGKK----KIFIYAKRHIDAGEEISYNY 1365
Cdd:cd10545    155 VGMSdgerssaedeessEFTIDAGSFGNVARFINHSCSPNLFVQCVLYDHNDlrlpRVMLFAADNIPPLQELTYDY 230
SET_SpSET3-like cd19183
SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET ...
 1260-1369 3.20e-13

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.


Pssm-ID: 380960  Cd Length: 173  Bit Score: 69.35  E-value: 3.20e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1260 DWGLVALEPIEAEDFVIEYVGEL-IRSSISEIRERQYEKMGIGSSYLFRLDDG-YVLDATKRGGIARFINHSCEPNC--Y 1335
Cdd:cd19183     13 RFGLFADRPIPAGDPIQELLGEIgLQSEYIADPENQYQILGAPKPHVFFHPQSpLYIDTRRSGSVARFIRRSCRPNAelV 92

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1063735663 1336 TKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPL 1369
Cdd:cd19183     93 TVASDSGSVLKFVLYASRDISPGEEITIGWDWDN 126
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 1256-1365 2.55e-09

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 56.62  E-value: 2.55e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1256 SKIHDWGLVALEPIEAEDFVIEY--VGELIRSSISEIRERQYEKMGigssyLFRLddgyvldatkrggiARFINHSCEPN 1333
Cdd:cd20071      6 EGSKGRGLVATRDIEPGELILVEkpLVSVPSNSFSLTDGLNEIGVG-----LFPL--------------ASLLNHSCDPN 66

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1063735663 1334 CytkIISVEGKKKIFIYAKRHIDAGEEISYNY 1365
Cdd:cd20071     67 A---VVVFDGNGTLRVRALRDIKAGEELTISY 95
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 1262-1365 4.10e-09

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 55.72  E-value: 4.10e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1262 GLVALEPIEAEDfVIEYVGELIRSsiseIRERQYEKMGIGSSYLFRLDDGYVLDATKRGGIArfiNHSCEPNCYTKIisV 1341
Cdd:cd10540     13 GVFATRPIKKGE-VIEEAPVIVLP----KEEYQHLCKTVLDHYVFSWGDGCLALALGYGSMF---NHSYTPNAEYEI--D 82

                           90       100
                   ....*....|....*....|....
gi 1063735663 1342 EGKKKIFIYAKRHIDAGEEISYNY 1365
Cdd:cd10540     83 FENQTIVFYALRDIEAGEELTINY 106
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 1321-1365 1.87e-08

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 54.59  E-value: 1.87e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1063735663 1321 GIARFINHSCEPNCytKIISVeGKKKIFIYAKRHIDAGEEISYNY 1365
Cdd:cd10524     75 GPAAFINHDCRPNC--KFVPT-GKSTACVKVLRDIEPGEEITVYY 116
SET_KMT2E cd19182
SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar ...
 1263-1367 5.19e-06

SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; KMT2E (also termed inactive lysine N-methyltransferase 2E, myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) plays a key role in hematopoiesis, spermatogenesis and cell cycle progression. It associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Lack of key residues in the SET domain as well as the presence of an unusually large loop in the SET-I subdomain preclude the interaction of MLL5 SET with its cofactor and substrate thus making MLL5 devoid of any in vitro methyltransferase activity on full-length histones and histone H3 peptide.


Pssm-ID: 380959  Cd Length: 129  Bit Score: 47.19  E-value: 5.19e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1263 LVALEPIEAEDFVIEYVGELIrssiseIRErQYEKMGigssYLFRLDDGYVL------------DATKRGGIARFINHSC 1330
Cdd:cd19182     21 LKAAKDLPPDTLIIEYRGKFM------LRE-QFEANG----YFFKRPYPFVLfyskfhglemcvDARTFGNEARFIRRSC 89

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1063735663 1331 EPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKF 1367
Cdd:cd19182     90 TPNAEVRHVIEDGTIHLYIYSIRSIPKGTEITIAFDF 126
SET_KMT5C cd19185
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) ...
 1281-1385 1.38e-05

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) and similar proteins; KMT5C (also termed lysine N-methyltransferase 5C, lysine-specific methyltransferase 5C, suppressor of variegation 4-20 homolog 2, Su(var)4-20 homolog 2 or Suv4-20h2) is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 (H4K20me3). It plays a central role in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380962  Cd Length: 142  Bit Score: 46.19  E-value: 1.38e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1281 ELIRSSISEIRERQYEKMGIGSsylfrlDDGYVLDATKRG------GIARFINHSCEPNCytKIISVEGKKKIfIYAKRH 1354
Cdd:cd19185     35 ELLVGCIAELREEDEGLLRAGE------NDFSIMYSTRKRsaqlwlGPAAFINHDCKPNC--KFVPADGNAAC-VKVLRD 105

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1063735663 1355 IDAGEEIS--YNYKFPLEDDKIpCNCGAPKCRG 1385
Cdd:cd19185    106 IEPGDEVTcfYGEGFFGEKNEH-CECHTCERKG 137
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 1325-1365 4.11e-05

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 46.52  E-value: 4.11e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1063735663 1325 FINHSCEPNCytkIISVEGkKKIFIYAKRHIDAGEEISYNY 1365
Cdd:cd10536    153 LLNHSCDPNT---IRSFYG-NTIVVRATRPIKKGEEITICY 189
SET_ATXR5_6-like cd10539
SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The ...
 1265-1365 4.51e-05

SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The family includes Arabidopsis thaliana ATXR5 and ATXR6. Both ATXR5 (also termed protein SET DOMAIN GROUP 15, or TRX-related protein 5) and ATXR6 (also termed protein SET DOMAIN GROUP 34, or TRX-related protein 6) function as histone methyltransferase that specifically monomethylates 'Lys-37' of histone H3 (H3K27me1). They are required for chromatin structure and gene silencing.


Pssm-ID: 380937  Cd Length: 138  Bit Score: 44.71  E-value: 4.51e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1265 ALEPIEAEDFVIEYVGElirssISEIRERQYEKmgiGSSYLFRLDDG-----YVLDATKRGGIARFI----NHSCE---- 1331
Cdd:cd10539     20 ADGFIKDLTIIAEYTGD-----VDYIRNREFDD---NDSIMTLLLAGdpsksLVICPDKRGNIARFIsginNHTKDgkkk 91

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1063735663 1332 PNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNY 1365
Cdd:cd10539     92 QNCKCVRYSINGEARVLLVATRDIAKGERLYYDY 125
SET_SETD5 cd19181
SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and ...
 1263-1378 7.43e-04

SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. SETD5 loss-of-function mutations are a likely cause of a familial syndromic intellectual disability with variable phenotypic expression.


Pssm-ID: 380958  Cd Length: 150  Bit Score: 41.53  E-value: 7.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1263 LVALEPIEAEDFVIEYVGELIrssiseIRErQYEKMGigssYLFRLDDGYVL------------DATKRGGIARFINHSC 1330
Cdd:cd19181     21 LRAARDLALDTLIIEYRGKVM------LRQ-QFEVNG----HFFKRPYPFVLfyskfngvemcvDARTFGNDARFIRRSC 89

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1063735663 1331 EPNCYTKIISVEGKKKIFIYAKRHI--DAGEEISYNYKFPLEDDKIPCNC 1378
Cdd:cd19181     90 TPNAEVRHMIADGMIHLCIYAVAAIakDAEVTIAFDYEYSNCNYKVDCAC 139
PostSET smart00508
Cysteine-rich motif following a subset of SET domains;
1372-1388 9.85e-04

Cysteine-rich motif following a subset of SET domains;


Pssm-ID: 214703  Cd Length: 17  Bit Score: 37.77  E-value: 9.85e-04
                            10
                    ....*....|....*..
gi 1063735663  1372 DKIPCNCGAPKCRGSLN 1388
Cdd:smart00508    1 KKQPCLCGAPNCRGFLG 17
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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