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Conserved domains on  [gi|1063743051|ref|NP_001331217|]
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Pyruvate kinase family protein [Arabidopsis thaliana]

Protein Classification

PLN02461 family protein( domain architecture ID 11476851)

PLN02461 family protein

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PLN02461 PLN02461
Probable pyruvate kinase
1-510 0e+00

Probable pyruvate kinase


:

Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 1082.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051   1 MSNIDIEGILKELPNDG-RTPKTKIVCTLGPASRSVTMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRTAMQNTGILA 79
Cdd:PLN02461    1 MANIDIEGILKGLPADGlRRPKTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILC 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  80 AVMLDTKGPEIRTGFLKDGNPIQLKEGQEITITTDYDIKGDEKTISMSYKKLPVDVKPGNTILCADGSISLAVVSCDPNA 159
Cdd:PLN02461   81 AVMLDTKGPEIRTGFLKDGKPVQLKQGQEITITTDYSIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLSCDVEA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 160 GTVICRCENTAMLGERKNVNLPGVVVDLPTLTDKDVEDILKWGVPNNIDMIALSFVRKGSDLVNVRKVLGSHSKSIMLMS 239
Cdd:PLN02461  161 GTVRCRCENSAMLGERKNVNLPGVVVDLPTLTEKDKEDILQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLIS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 240 KVENQEGVLNFDEILRETDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVA 319
Cdd:PLN02461  241 KVENQEGLDNFDDILAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVA 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 320 NAVLDGTDCVMLSGESAAGAYPEIAVKTMAKICIEAESSLDYNTIFKEMIRATPLPMSTLESLASSAVRTANKAKAKLII 399
Cdd:PLN02461  321 NAVLDGTDCVMLSGETAAGAYPELAVKTMARICREAEASLDYGALFKEIMRSAPLPMSPLESLASSAVRTANKVKASLIV 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 400 VLTRGGTTAKLVAKYRPAVPILSVVVPVFTSDTFNWSCSDESPARHSLIYRGLIPVLGEGSAKATDSESTEEIIESALKS 479
Cdd:PLN02461  401 VLTRGGTTARLVAKYRPAVPILSVVVPEITTDSFDWSCSDEAPARHSLIYRGLIPVLAEGSAKATDSESTEEILEAAIEH 480
                         490       500       510
                  ....*....|....*....|....*....|.
gi 1063743051 480 ATEKGLCNHGDAVVALHRIGAASVIKICVVK 510
Cdd:PLN02461  481 AKKKGLCKPGDSVVALHRIGGASVIKILTVK 511
 
Name Accession Description Interval E-value
PLN02461 PLN02461
Probable pyruvate kinase
1-510 0e+00

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 1082.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051   1 MSNIDIEGILKELPNDG-RTPKTKIVCTLGPASRSVTMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRTAMQNTGILA 79
Cdd:PLN02461    1 MANIDIEGILKGLPADGlRRPKTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILC 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  80 AVMLDTKGPEIRTGFLKDGNPIQLKEGQEITITTDYDIKGDEKTISMSYKKLPVDVKPGNTILCADGSISLAVVSCDPNA 159
Cdd:PLN02461   81 AVMLDTKGPEIRTGFLKDGKPVQLKQGQEITITTDYSIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLSCDVEA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 160 GTVICRCENTAMLGERKNVNLPGVVVDLPTLTDKDVEDILKWGVPNNIDMIALSFVRKGSDLVNVRKVLGSHSKSIMLMS 239
Cdd:PLN02461  161 GTVRCRCENSAMLGERKNVNLPGVVVDLPTLTEKDKEDILQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLIS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 240 KVENQEGVLNFDEILRETDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVA 319
Cdd:PLN02461  241 KVENQEGLDNFDDILAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVA 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 320 NAVLDGTDCVMLSGESAAGAYPEIAVKTMAKICIEAESSLDYNTIFKEMIRATPLPMSTLESLASSAVRTANKAKAKLII 399
Cdd:PLN02461  321 NAVLDGTDCVMLSGETAAGAYPELAVKTMARICREAEASLDYGALFKEIMRSAPLPMSPLESLASSAVRTANKVKASLIV 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 400 VLTRGGTTAKLVAKYRPAVPILSVVVPVFTSDTFNWSCSDESPARHSLIYRGLIPVLGEGSAKATDSESTEEIIESALKS 479
Cdd:PLN02461  401 VLTRGGTTARLVAKYRPAVPILSVVVPEITTDSFDWSCSDEAPARHSLIYRGLIPVLAEGSAKATDSESTEEILEAAIEH 480
                         490       500       510
                  ....*....|....*....|....*....|.
gi 1063743051 480 ATEKGLCNHGDAVVALHRIGAASVIKICVVK 510
Cdd:PLN02461  481 AKKKGLCKPGDSVVALHRIGGASVIKILTVK 511
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
20-509 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 726.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  20 PKTKIVCTLGPASRSVTMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRTAMQNTGILAAVMLDTKGPEIRTGFLKDGN 99
Cdd:cd00288     2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGGK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 100 PIQLKEGQEITITTDY-DIKGDEKTISMSYKKLPVDVKPGNTILCADGSISLAVVSCDPNAgTVICRCENTAMLGERKNV 178
Cdd:cd00288    82 DISLKAGDKFLVTTDPaAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDK-TLVCEVLNGGVLGSRKGV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 179 NLPGVVVDLPTLTDKDVEDIlKWGVPNNIDMIALSFVRKGSDLVNVRKVLGSHSKSIMLMSKVENQEGVLNFDEILRETD 258
Cdd:cd00288   161 NLPGTDVDLPALSEKDKADL-RFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASD 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 259 AFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGESAAG 338
Cdd:cd00288   240 GIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 339 AYPEIAVKTMAKICIEAESSLDYNTIFKEMIRATPLPMSTLESLASSAVRTANKAKAKLIIVLTRGGTTAKLVAKYRPAV 418
Cdd:cd00288   320 KYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNA 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 419 PILSVvvpvftsdTFNwscsdESPARHSLIYRGLIPVLGEgSAKATDSESTEEIIESALKSATEKGLCNHGDAVVALHRI 498
Cdd:cd00288   400 PIIAV--------TRN-----EQTARQLHLYRGVYPVLFE-EPKPGWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGW 465
                         490
                  ....*....|....*
gi 1063743051 499 ----GAASVIKICVV 509
Cdd:cd00288   466 pvgsGSTNTMRILTV 480
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
21-509 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 638.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  21 KTKIVCTLGPASRSVTMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRTAMQNTGILAAVMLDTKGPEIRTGFLKDGnP 100
Cdd:COG0469     4 RTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG-P 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 101 IQLKEGQEITITTDyDIKGDEKTISMSYKKLPVDVKPGNTILCADGSISLAVVSCDPNAgtVICRCENTAMLGERKNVNL 180
Cdd:COG0469    83 VELKKGDTFTLTTD-DVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDE--VVCEVVNGGVLSSRKGVNL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 181 PGVVVDLPTLTDKDVEDIlKWGVPNNIDMIALSFVRKGSDLVNVRKVLGSHSKSIMLMSKVENQEGVLNFDEILRETDAF 260
Cdd:COG0469   160 PGVGLSLPALTEKDREDL-KFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGI 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 261 MVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGESAAGAY 340
Cdd:COG0469   239 MVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKY 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 341 PEIAVKTMAKICIEAESSLDYNTIFKEmiRATPLPMSTLESLASSAVRTANKAKAKLIIVLTRGGTTAKLVAKYRPAVPI 420
Cdd:COG0469   319 PVEAVETMARIAEEAEKSLDYRRILDR--LRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPI 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 421 LSVvvpvftsdtfnwsCSDESPARHSLIYRGLIPVLGEgsakatDSESTEEIIESALKSATEKGLCNHGDAVV-----AL 495
Cdd:COG0469   397 LAL-------------TPNERTARRLALVWGVYPVLVD------DVESTDEMIEEAVEALLEEGLVKPGDLVVitagvPV 457
                         490
                  ....*....|....
gi 1063743051 496 HRIGAASVIKICVV 509
Cdd:COG0469   458 GVPGTTNTLKVHRV 471
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
21-503 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 564.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  21 KTKIVCTLGPASRSVTMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRTAMQNTGILAAVMLDTKGPEIRTGFLKDGnP 100
Cdd:TIGR01064   2 RTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGG-E 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 101 IQLKEGQEITITTDYDIK-GDEKTISMSYKKLPVDVKPGNTILCADGSISLAVVSCDPNagTVICRCENTAMLGERKNVN 179
Cdd:TIGR01064  81 VKLKKGDKVIITTDDIKGeGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGD--KVICEVLNGGTLKSKKGVN 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 180 LPGVVVDLPTLTDKDVEDIlKWGVPNNIDMIALSFVRKGSDLVNVRKVLGSH-SKSIMLMSKVENQEGVLNFDEILRETD 258
Cdd:TIGR01064 159 LPGADVDLPALSEKDKKDL-KFGVEQGVDMVAASFVRTAEDVLEVREVLGEKgAKDVKIIAKIENQEGVDNIDEIAEASD 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 259 AFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGESAAG 338
Cdd:TIGR01064 238 GIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKG 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 339 AYPEIAVKTMAKICIEAESSLDYNTIFKEMIRATPLPMSTLESLASSAVRTANKAKAKLIIVLTRGGTTAKLVAKYRPAV 418
Cdd:TIGR01064 318 KYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNA 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 419 PILSVVVpvftsdtfnwscsDESPARHSLIYRGLIPVLGEGSAkatdsESTEEIIESALKSATEKGLCNHGDAVVALHRI 498
Cdd:TIGR01064 398 PIIAVTP-------------NERVARQLALYWGVFPFLVDEEP-----SDTDARVNKALELLKEKGIVKKGDLVVVIQGG 459

                  ....*
gi 1063743051 499 GAASV 503
Cdd:TIGR01064 460 PIGGE 464
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
20-365 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 562.37  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  20 PKTKIVCTLGPASRSVTMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRTAMQNTGILAAVMLDTKGPEIRTGFLKDG- 98
Cdd:pfam00224   2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDGk 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  99 NPIQLKEGQEITITTDYDIKG--DEKTISMSYKKLPVDVKPGNTILCADGSISLAVVSCDPnAGTVICRCENTAMLGERK 176
Cdd:pfam00224  82 KDIELKAGDEMIVSTDAKYKGacDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDD-DKTLVVEVLNGGVIGSRK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 177 NVNLPGVVVDLPTLTDKDVEDIlKWGVPNNIDMIALSFVRKGSDLVNVRKVLGSHSKSIMLMSKVENQEGVLNFDEILRE 256
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADL-RFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEA 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 257 TDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGESA 336
Cdd:pfam00224 240 TDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETA 319
                         330       340
                  ....*....|....*....|....*....
gi 1063743051 337 AGAYPEIAVKTMAKICIEAESSLDYNTIF 365
Cdd:pfam00224 320 KGNYPVEAVRMMHEICLEAEKALPHRNLF 348
 
Name Accession Description Interval E-value
PLN02461 PLN02461
Probable pyruvate kinase
1-510 0e+00

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 1082.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051   1 MSNIDIEGILKELPNDG-RTPKTKIVCTLGPASRSVTMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRTAMQNTGILA 79
Cdd:PLN02461    1 MANIDIEGILKGLPADGlRRPKTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILC 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  80 AVMLDTKGPEIRTGFLKDGNPIQLKEGQEITITTDYDIKGDEKTISMSYKKLPVDVKPGNTILCADGSISLAVVSCDPNA 159
Cdd:PLN02461   81 AVMLDTKGPEIRTGFLKDGKPVQLKQGQEITITTDYSIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLSCDVEA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 160 GTVICRCENTAMLGERKNVNLPGVVVDLPTLTDKDVEDILKWGVPNNIDMIALSFVRKGSDLVNVRKVLGSHSKSIMLMS 239
Cdd:PLN02461  161 GTVRCRCENSAMLGERKNVNLPGVVVDLPTLTEKDKEDILQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLIS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 240 KVENQEGVLNFDEILRETDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVA 319
Cdd:PLN02461  241 KVENQEGLDNFDDILAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVA 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 320 NAVLDGTDCVMLSGESAAGAYPEIAVKTMAKICIEAESSLDYNTIFKEMIRATPLPMSTLESLASSAVRTANKAKAKLII 399
Cdd:PLN02461  321 NAVLDGTDCVMLSGETAAGAYPELAVKTMARICREAEASLDYGALFKEIMRSAPLPMSPLESLASSAVRTANKVKASLIV 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 400 VLTRGGTTAKLVAKYRPAVPILSVVVPVFTSDTFNWSCSDESPARHSLIYRGLIPVLGEGSAKATDSESTEEIIESALKS 479
Cdd:PLN02461  401 VLTRGGTTARLVAKYRPAVPILSVVVPEITTDSFDWSCSDEAPARHSLIYRGLIPVLAEGSAKATDSESTEEILEAAIEH 480
                         490       500       510
                  ....*....|....*....|....*....|.
gi 1063743051 480 ATEKGLCNHGDAVVALHRIGAASVIKICVVK 510
Cdd:PLN02461  481 AKKKGLCKPGDSVVALHRIGGASVIKILTVK 511
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
20-509 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 726.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  20 PKTKIVCTLGPASRSVTMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRTAMQNTGILAAVMLDTKGPEIRTGFLKDGN 99
Cdd:cd00288     2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGGK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 100 PIQLKEGQEITITTDY-DIKGDEKTISMSYKKLPVDVKPGNTILCADGSISLAVVSCDPNAgTVICRCENTAMLGERKNV 178
Cdd:cd00288    82 DISLKAGDKFLVTTDPaAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDK-TLVCEVLNGGVLGSRKGV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 179 NLPGVVVDLPTLTDKDVEDIlKWGVPNNIDMIALSFVRKGSDLVNVRKVLGSHSKSIMLMSKVENQEGVLNFDEILRETD 258
Cdd:cd00288   161 NLPGTDVDLPALSEKDKADL-RFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASD 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 259 AFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGESAAG 338
Cdd:cd00288   240 GIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 339 AYPEIAVKTMAKICIEAESSLDYNTIFKEMIRATPLPMSTLESLASSAVRTANKAKAKLIIVLTRGGTTAKLVAKYRPAV 418
Cdd:cd00288   320 KYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNA 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 419 PILSVvvpvftsdTFNwscsdESPARHSLIYRGLIPVLGEgSAKATDSESTEEIIESALKSATEKGLCNHGDAVVALHRI 498
Cdd:cd00288   400 PIIAV--------TRN-----EQTARQLHLYRGVYPVLFE-EPKPGWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGW 465
                         490
                  ....*....|....*
gi 1063743051 499 ----GAASVIKICVV 509
Cdd:cd00288   466 pvgsGSTNTMRILTV 480
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
21-509 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 638.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  21 KTKIVCTLGPASRSVTMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRTAMQNTGILAAVMLDTKGPEIRTGFLKDGnP 100
Cdd:COG0469     4 RTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG-P 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 101 IQLKEGQEITITTDyDIKGDEKTISMSYKKLPVDVKPGNTILCADGSISLAVVSCDPNAgtVICRCENTAMLGERKNVNL 180
Cdd:COG0469    83 VELKKGDTFTLTTD-DVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDE--VVCEVVNGGVLSSRKGVNL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 181 PGVVVDLPTLTDKDVEDIlKWGVPNNIDMIALSFVRKGSDLVNVRKVLGSHSKSIMLMSKVENQEGVLNFDEILRETDAF 260
Cdd:COG0469   160 PGVGLSLPALTEKDREDL-KFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGI 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 261 MVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGESAAGAY 340
Cdd:COG0469   239 MVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKY 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 341 PEIAVKTMAKICIEAESSLDYNTIFKEmiRATPLPMSTLESLASSAVRTANKAKAKLIIVLTRGGTTAKLVAKYRPAVPI 420
Cdd:COG0469   319 PVEAVETMARIAEEAEKSLDYRRILDR--LRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPI 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 421 LSVvvpvftsdtfnwsCSDESPARHSLIYRGLIPVLGEgsakatDSESTEEIIESALKSATEKGLCNHGDAVV-----AL 495
Cdd:COG0469   397 LAL-------------TPNERTARRLALVWGVYPVLVD------DVESTDEMIEEAVEALLEEGLVKPGDLVVitagvPV 457
                         490
                  ....*....|....
gi 1063743051 496 HRIGAASVIKICVV 509
Cdd:COG0469   458 GVPGTTNTLKVHRV 471
PTZ00066 PTZ00066
pyruvate kinase; Provisional
2-499 0e+00

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 571.32  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051   2 SNIDIEGILKELP-NDGRTPKTKIVCTLGPASRSVTMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRTAM-QNTGILA 79
Cdd:PTZ00066   19 TNISLDKILEPISdNDLRQKKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAAkARPNANL 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  80 AVMLDTKGPEIRTGFLKDGNPIQLKEGQEITITTDYDIKGDEKTISMSYKKLPVDVKPGNTILCADGSISLAVVSCDPNa 159
Cdd:PTZ00066   99 GILLDTKGPEIRTGFLKNHKPITLKEGQTLKITTDYTFLGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDD- 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 160 gTVICRCENTAMLGERKNVNLPGVVVDLPTLTDKDVEDILKWGVPNNIDMIALSFVRKGSDLVNVRKVLGSHSKSIMLMS 239
Cdd:PTZ00066  178 -YIITKVLNNATIGERKNMNLPGVKVELPVIGEKDKNDILNFAIPMGCDFIALSFVQSADDVRLCRQLLGERGRHIKIIP 256
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 240 KVENQEGVLNFDEILRETDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVA 319
Cdd:PTZ00066  257 KIENIEGLINFDEILAESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVA 336
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 320 NAVLDGTDCVMLSGESAAGAYPEIAVKTMAKICIEAESSLDYNTIFKEMIRATPLPMSTLESLASSAVRTANKAKAKLII 399
Cdd:PTZ00066  337 NAVLDGTDCVMLSGETANGKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPTPVSVQEAVARSAVETAEDINAKLII 416
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 400 VLTRGGTTAKLVAKYRPAVPILSVvvpvftsdtfnwsCSDESPARHSLIYRGLIpvlgegSAKATDSESTEEIIESALKS 479
Cdd:PTZ00066  417 ALTETGNTARLISKYRPSCTILAL-------------SASPSVVKSLSVARGVT------TYVVNSFQGTDVVIRNAIAL 477
                         490       500
                  ....*....|....*....|
gi 1063743051 480 ATEKGLCNHGDAVVALHRIG 499
Cdd:PTZ00066  478 AKERGLVESGDSAIAVHGVK 497
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
21-503 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 564.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  21 KTKIVCTLGPASRSVTMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRTAMQNTGILAAVMLDTKGPEIRTGFLKDGnP 100
Cdd:TIGR01064   2 RTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGG-E 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 101 IQLKEGQEITITTDYDIK-GDEKTISMSYKKLPVDVKPGNTILCADGSISLAVVSCDPNagTVICRCENTAMLGERKNVN 179
Cdd:TIGR01064  81 VKLKKGDKVIITTDDIKGeGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGD--KVICEVLNGGTLKSKKGVN 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 180 LPGVVVDLPTLTDKDVEDIlKWGVPNNIDMIALSFVRKGSDLVNVRKVLGSH-SKSIMLMSKVENQEGVLNFDEILRETD 258
Cdd:TIGR01064 159 LPGADVDLPALSEKDKKDL-KFGVEQGVDMVAASFVRTAEDVLEVREVLGEKgAKDVKIIAKIENQEGVDNIDEIAEASD 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 259 AFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGESAAG 338
Cdd:TIGR01064 238 GIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKG 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 339 AYPEIAVKTMAKICIEAESSLDYNTIFKEMIRATPLPMSTLESLASSAVRTANKAKAKLIIVLTRGGTTAKLVAKYRPAV 418
Cdd:TIGR01064 318 KYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNA 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 419 PILSVVVpvftsdtfnwscsDESPARHSLIYRGLIPVLGEGSAkatdsESTEEIIESALKSATEKGLCNHGDAVVALHRI 498
Cdd:TIGR01064 398 PIIAVTP-------------NERVARQLALYWGVFPFLVDEEP-----SDTDARVNKALELLKEKGIVKKGDLVVVIQGG 459

                  ....*
gi 1063743051 499 GAASV 503
Cdd:TIGR01064 460 PIGGE 464
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
20-365 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 562.37  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  20 PKTKIVCTLGPASRSVTMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRTAMQNTGILAAVMLDTKGPEIRTGFLKDG- 98
Cdd:pfam00224   2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDGk 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  99 NPIQLKEGQEITITTDYDIKG--DEKTISMSYKKLPVDVKPGNTILCADGSISLAVVSCDPnAGTVICRCENTAMLGERK 176
Cdd:pfam00224  82 KDIELKAGDEMIVSTDAKYKGacDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDD-DKTLVVEVLNGGVIGSRK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 177 NVNLPGVVVDLPTLTDKDVEDIlKWGVPNNIDMIALSFVRKGSDLVNVRKVLGSHSKSIMLMSKVENQEGVLNFDEILRE 256
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADL-RFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEA 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 257 TDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGESA 336
Cdd:pfam00224 240 TDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETA 319
                         330       340
                  ....*....|....*....|....*....
gi 1063743051 337 AGAYPEIAVKTMAKICIEAESSLDYNTIF 365
Cdd:pfam00224 320 KGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
21-493 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 527.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  21 KTKIVCTLGPASRSVTMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRTAMQNTGILAAVMLDTKGPEIRTGFLKDGnP 100
Cdd:PRK05826    5 RTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKEG-K 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 101 IQLKEGQEITITTDYDIKGDEKTISMSYKKLPVDVKPGNTILCADGSISLAVVSCDPNagTVICRCENTAMLGERKNVNL 180
Cdd:PRK05826   84 ITLKTGDKFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGD--EVETEVKNGGPLSNNKGINI 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 181 PGVVVDLPTLTDKDVEDIlKWGVPNNIDMIALSFVRKGSDLVNVRKVLGSH-SKSIMLMSKVENQEGVLNFDEILRETDA 259
Cdd:PRK05826  162 PGGGLSLPALTEKDKADI-KFAAEQGVDYIAVSFVRSAEDVEEARRLLREAgCPHAKIIAKIERAEAVDNIDEIIEASDG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 260 FMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGESAAGA 339
Cdd:PRK05826  241 IMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGK 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 340 YPEIAVKTMAKICIEAESSLDYNTIFKEMIRATplpMSTLESLASSAVRTANKAK-AKLIIVLTRGGTTAKLVAKYRPAV 418
Cdd:PRK05826  321 YPVEAVEAMARICKGAEKEFSINLSKHRLDRQF---DRIDEAIAMSAMYAANHLKgVKAIVALTESGRTARLISRFRPGA 397
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063743051 419 PILSVvvpvftsdtfnwsCSDESPARHSLIYRGLIPVLGEGSAkatdseSTEEIIESALKSATEKGLCNHGDAVV 493
Cdd:PRK05826  398 PIFAV-------------TRDEKTQRRLALYRGVYPVLFDSAA------DTDDAAEEALRLLLEKGLVESGDLVV 453
PLN02765 PLN02765
pyruvate kinase
22-506 0e+00

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 522.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  22 TKIVCTLGPASRSVTMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRTAMQNTGILAAVMLDTKGPEIRTgFLKDGNPI 101
Cdd:PLN02765   30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQV-INKTEKPI 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 102 QLKEGQEITITTDYDIKGDEKTISMSYKKLPVDVKPGNTILCAD--------GSISLAVVscDPNAGTVICRCENTAML- 172
Cdd:PLN02765  109 SLKAGNTVTLTPDQSKEASSEVLPINFPGLAKAVKPGDTIFVGQylftgsetTSVWLEVD--EVKGDDVVCTVKNSATLa 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 173 GERKNVNLPGVVVDLPTLTDKDVEDILKWGVPNNIDMIALSFVRKGSDLVNVRKVLGSHS-KSIMLMSKVENQEGVLNFD 251
Cdd:PLN02765  187 GSLFTLHVSQVRIDLPTLSEKDKEVISTWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGlSQTQIFAKIENVEGLTHFD 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 252 EILRETDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTaTQMLESMIKSPRPTRAEATDVANAVLDGTDCVML 331
Cdd:PLN02765  267 EILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLDGADAILL 345
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 332 SGESAAGAYPEIAVKTMAKICIEAESSLDYNTIFKEMIRATPLPMSTLESLASSAVRTANKAKAKLIIVLTRGGTTAKLV 411
Cdd:PLN02765  346 GAETLRGLYPVETISTVGRICAEAEKVFNQDLYFKKTVKYVGEPMSHLESIASSAVRAAIKVKASVIIVFTSSGRAARLI 425
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 412 AKYRPAVPILSVVVPVFTSDTFNWSCSDESPARHSLIYRGLIPVLGEGSAKATDSESTEE-IIESALKSATEKGLCNHGD 490
Cdd:PLN02765  426 AKYRPTMPVLSVVIPRLKTNQLKWSFTGAFQARQCLIVRGLFPMLADPRHSAESTSATNEsVLKVALDHGKAAGVIKSHD 505
                         490
                  ....*....|....*.
gi 1063743051 491 AVVALHRIGAASVIKI 506
Cdd:PLN02765  506 RVVVCQKVGDSSVVKI 521
PRK09206 PRK09206
pyruvate kinase PykF;
21-493 4.64e-179

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 511.14  E-value: 4.64e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  21 KTKIVCTLGPASRSVTMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRTAMQNTGILAAVMLDTKGPEIRTGFLKDGNP 100
Cdd:PRK09206    3 KTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGGND 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 101 IQLKEGQEITITTDYDIKGDEKTISMSYKKLPVDVKPGNTILCADGSISLAVVSCdpNAGTVICRCENTAMLGERKNVNL 180
Cdd:PRK09206   83 VSLKAGQTFTFTTDKSVVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAI--TGNEVICKVLNNGDLGENKGVNL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 181 PGVVVDLPTLTDKDVEDiLKWGVPNNIDMIALSFVRKGSDLVNVRKVLGSHS-KSIMLMSKVENQEGVLNFDEILRETDA 259
Cdd:PRK09206  161 PGVSIALPALAEKDKQD-LIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGgENIQIISKIENQEGLNNFDEILEASDG 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 260 FMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGESAAGA 339
Cdd:PRK09206  240 IMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGK 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 340 YPEIAVKTMAKICIEAE----SSLDYNTIFKEMiRATplpmstlESLASSAVRTANKAKAKLIIVLTRGGTTAKLVAKYR 415
Cdd:PRK09206  320 YPLEAVSIMATICERTDrvmnSRLESNNDNRKL-RIT-------EAVCRGAVETAEKLDAPLIVVATQGGKSARSVRKYF 391
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063743051 416 PAVPILSVVvpvftsdtfnwscSDESPARHSLIYRGLIPVLgegsAKATDseSTEEIIESALKSATEKGLCNHGDAVV 493
Cdd:PRK09206  392 PDATILALT-------------TNEKTARQLVLSKGVVPQL----VKEIA--STDDFYRLGKELALQSGLAQKGDVVV 450
PRK06354 PRK06354
pyruvate kinase; Provisional
21-493 3.43e-158

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 462.47  E-value: 3.43e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  21 KTKIVCTLGPASRSVTMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRTAMQNTGILAAVMLDTKGPEIRTGFLKDGnP 100
Cdd:PRK06354    9 RTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEDG-P 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 101 IQLKEGQEITITTDyDIKGDEKTISMSYKKLPVDVKPGNTILCADGSISLAVVSCDPNAGTVICRCENTAMLGERKNVNL 180
Cdd:PRK06354   88 IELKTGDEFILTSR-EVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADGELHCKVLVGGVLSNKKGVNF 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 181 PGVVVDLPTLTDKDVEDILkWGVPNNIDMIALSFVRKGSDLVNVRKVLGSHS-KSIMLMSKVENQEGVLNFDEILRETDA 259
Cdd:PRK06354  167 PGVSLSLPAITEKDREDLI-FGLEQGVDWIALSFVRNPSDVLEIRELIEEHNgKHIPIIAKIEKQEAIDNIDAILELCDG 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 260 FMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGESAAGA 339
Cdd:PRK06354  246 LMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAGD 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 340 YPEIAVKTMAKICIEAESSLDYNTIFKEMiratPLPMSTLESLASSAV-RTANKAKAKLIIVLTRGGTTAKLVAKYRPAV 418
Cdd:PRK06354  326 YPVEAVQTMATIAVRIEKDLPYRDILSKR----PEFTTTITNAISQAVsHIALQLDAAAIVTLTKSGATARNVSKYRPKT 401
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063743051 419 PILSVVvpvftsdtfnwscSDESPARH-SLIYrGLIPVLGEgsakatDSESTEEIIESALKSATEKGLCNHGDAVV 493
Cdd:PRK06354  402 PILAVT-------------PNESVARRlQLVW-GVTPLLVL------DAPSTDETFDAAINVAQESGLLKQGDLVV 457
PTZ00300 PTZ00300
pyruvate kinase; Provisional
46-496 6.78e-144

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 421.00  E-value: 6.78e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  46 MNVARFNFSHGSHEYHQETLDNLRTAMQNTGILAAVMLDTKGPEIRTGFLKDGNPIqLKEGQEITITTD--YDIKGDEKT 123
Cdd:PTZ00300    1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAV-MERGATCYVTTDpaFADKGTKDK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 124 ISMSYKKLPVDVKPGNTILCADGSISLAVVSCDpNAGTVICRCENTAMLGERKNVNLPGVVVDLPTLTDKDVEDiLKWGV 203
Cdd:PTZ00300   80 FYIDYQNLSKVVRPGGYIYIDDGILILHVQSHE-DEQTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCAD-LQFGV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 204 PNNIDMIALSFVRKGSDLVNVRKVLGSHSKSIMLMSKVENQEGVLNFDEILRETDAFMVARGDLGMEIPIEKIFLAQKMM 283
Cdd:PTZ00300  158 EQGVDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKIL 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 284 IYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGESAAGAYPEIAVKTMAKICIEAESSLDYNT 363
Cdd:PTZ00300  238 ISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNEYV 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 364 IFKEMIRATPLPMSTLESLASSAVRTANKAKAKLIIVLTRGGTTAKLVAKYRPAVPILSVVVPVFTSDTFNwscsdespa 443
Cdd:PTZ00300  318 FFNSIKKLQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLN--------- 388
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1063743051 444 rhslIYRGLIPVLGEGSAKATDsESTEEIIESALKSATEKGLCNHGDAVVALH 496
Cdd:PTZ00300  389 ----ITQGVESVFFDAERLGHD-EGKEQRVAMGVGFAKSKGYVQSGDLMVVVH 436
PRK06247 PRK06247
pyruvate kinase; Provisional
18-493 2.51e-142

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 417.79  E-value: 2.51e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  18 RTPKTKIVCTLGPASRSVTMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRTAMQNTGILAAVMLDTKGPEIRTGFLKD 97
Cdd:PRK06247    3 RNRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFAD 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  98 GnPIQLKEGQEITITTDyDIKGDEKTISMSYKKLPVDVKPGNTILCADGSISLAVVSCDPNAgtVICRCENTAMLGERKN 177
Cdd:PRK06247   83 G-KVQLANGQTFRLDVD-DAPGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDD--VVCRVVEGGPVSDRKG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 178 VNLPGVVVDLPTLTDKDVEDiLKWGVPNNIDMIALSFVRKGSDLVNVRKVLGSHsksIMLMSKVENQEGVLNFDEILRET 257
Cdd:PRK06247  159 VSLPGTVLSVSALTEKDRAD-LEFALELGVDWVALSFVQRPEDVEEVRKIIGGR---VPVMAKIEKPQAIDRLEAIVEAS 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 258 DAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGESAA 337
Cdd:PRK06247  235 DAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETAS 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 338 GAYPEIAVKTMAKICIEAESSLDYNTIfkemIRAT-PLPMSTLESLASSAVR-TANKAKAKLIIVLTRGGTTAKLVAKYR 415
Cdd:PRK06247  315 GKYPVEAVRTMARIIRQVERDPTYPPL----IHAQrPQPEATKRDAISYAARdIAERLDLAALVAYTSSGDTALRAARER 390
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063743051 416 PAVPILsvvvpVFTSDTfnwscsdESPARHSLIYrGLIPVLGEgsakatDSESTEEIIESALKSATEKGLCNHGDAVV 493
Cdd:PRK06247  391 PPLPIL-----ALTPNP-------ETARRLALTW-GVHCVVVD------DARDTDDMVRRADRIALAEGFYKRGDRVV 449
PLN02623 PLN02623
pyruvate kinase
21-492 3.19e-106

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 328.81  E-value: 3.19e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  21 KTKIVCTLGPASRSVTMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRT-AMQNTGILAAVMLDTKGPEIRTGFLKDgn 99
Cdd:PLN02623  111 KTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEyNAQSKDNVIAIMLDTKGPEVRSGDLPQ-- 188
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 100 PIQLKEGQEITITTDYDIkGDEKTISMSYKKLPVDVKPGNTILCADGSISLAVVScdPNAGTVICRCENTAMLGERKNVN 179
Cdd:PLN02623  189 PIMLEEGQEFTFTIKRGV-STEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKS--KTSDSVKCEVVDGGELKSRRHLN 265
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 180 LPGVVVDLPTLTDKDVEDIlKWGVPNNIDMIALSFVRKGSDLVNVRKVLGSHSKSIMLMSKVENQEGVLNFDEILRETDA 259
Cdd:PLN02623  266 VRGKSATLPSITEKDWEDI-KFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNADIHVIVKIESADSIPNLHSIITASDG 344
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 260 FMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGESAAGA 339
Cdd:PLN02623  345 AMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGK 424
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 340 YPEIAVKTMAKICIEAESSLDYNTIFKEMIRATPLPMStlESLASSAVRTANKAKAKlIIVLTRGGTTAKLVAKYRPAVP 419
Cdd:PLN02623  425 FPLKAVKVMHTVALRTEATLPEGTTPPNLGQAFKNHMS--EMFAFHATMMANTLGTS-IIVFTRTGFMAILLSHYRPSGT 501
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063743051 420 ILSvvvpvFTsdtfnwscSDESPARHSLIYRGLIPVLGEGSAKAtdsestEEIIESALKSATEKGLCNHGDAV 492
Cdd:PLN02623  502 IFA-----FT--------NEKRIQQRLALYQGVCPIYMQFSDDA------EETFARALSLLLNKGMVKEGEEV 555
PRK06739 PRK06739
pyruvate kinase; Validated
25-356 3.50e-87

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 272.20  E-value: 3.50e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  25 VCTLGPASRSVTMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRTAMQNTGILAavmlDTKGPEIRTGFLKdGNPIQLK 104
Cdd:PRK06739    6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDDSIKILG----DVQGPKIRLGEIK-GEQITLQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 105 EGQEITITTDyDIKGDEKTISMSYKKLPVDVKPGNTILCADGSISLAV--VSCDpnagTVICRCENTAMLGERKNVNLPG 182
Cdd:PRK06739   81 AGDSFILHTQ-PVTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVekVSTD----KIETKVKTGGNISSHKGVNLPG 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 183 VVVDLPTLTDKDVEDIlKWGVPNNIDMIALSFVRKGSDLVNVRKVLGSHSK-SIMLMSKVENQEGVLNFDEILRETDAFM 261
Cdd:PRK06739  156 AIVRLPAITEKDKKDI-QFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKEtSPNLIAKIETMEAIENFQDICKEADGIM 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 262 VARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGESAAGAYP 341
Cdd:PRK06739  235 IARGDLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHP 314
                         330
                  ....*....|....*
gi 1063743051 342 EIAVKTMAKICIEAE 356
Cdd:PRK06739  315 IESVSTLRLVSEFAE 329
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
19-510 1.11e-86

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 275.86  E-value: 1.11e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  19 TPKTKIVCTLGPASRSVTMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRTAMQNTGILAAVMLDTKGPEIRTGFLKDG 98
Cdd:PLN02762   24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGDLGGA 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  99 NPIQLKEGQEITITT-DYDIKGDEKTISMSYKKLPVDVKPGNTILCADGSISLAVVscDPNAGTVICRCENTAMLGERKN 177
Cdd:PLN02762  104 SSAKAEDGEEWTFTVrKFDGSRPEFTIQVNYDGFAEDVKVGDELVVDGGMVRFEVI--EKIGPDVKCKCTDPGLLLPRAN 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 178 VNL--PGVVVD-----LPTLTDKDVEDIlKWGVPNNIDMIALSFVRKGSDLVNVRKVLGSHS--KSIMLMSKVENQEGVL 248
Cdd:PLN02762  182 LTFwrDGSLVRernamLPTISSKDWLDI-DFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSrdSDIGVIAKIESLDSLK 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 249 NFDEILRETDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDC 328
Cdd:PLN02762  261 NLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRADA 340
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 329 VMLSGESAAGAYPEIAVKTMAKICIEAESSLDYNTIFKEMIR---ATPLPMSTLESLASSAVRTANKAKAKLIIVLTRGG 405
Cdd:PLN02762  341 LMLSGESAMGLYPEKALSVLRSVSLRMELWSREEKRHEALELpqlSSSLSDRISEEICNSAAKMANNLGVDAIFVYTKHG 420
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 406 TTAKLVAKYRPAVPILSvvvpvFTSDTfnwscsdesPARHSL-IYRGLIPVLGEGSakaTDSESTEEIIESALKSateKG 484
Cdd:PLN02762  421 HMASLLSRNRPDCPIFA-----FTDTT---------SVRRRLnLQWGLIPFRLDFS---DDMESNLNKTFSLLKA---RG 480
                         490       500
                  ....*....|....*....|....*.
gi 1063743051 485 LCNHGDAVVALHRIGAASVIKICVVK 510
Cdd:PLN02762  481 MIKSGDLVIAVSDLTPSSMLQSIQVR 506
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
286-493 5.41e-47

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 165.84  E-value: 5.41e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 286 KCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGESAAGAYPEIAVKTMAKICIEAESSLDYNTIF 365
Cdd:COG3848     1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 366 KEmiRATPLPMSTLESLASSAVRTANKAKAKLIIVLTRGGTTAKLVAKYRPAVPILSVVvpvftsdtfnwscSDESPARH 445
Cdd:COG3848    81 VP--RAKESSTTITDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVT-------------PSERVARQ 145
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1063743051 446 SLIYRGLIPVLGEgsakatDSESTEEIIESALKSATEKGLCNHGDAVV 493
Cdd:COG3848   146 LSLVWGVYPLLVE------ESASTDEMFAVAVALALEAGLVKDGDLVV 187
PRK08187 PRK08187
pyruvate kinase; Validated
19-331 1.04e-42

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 158.64  E-value: 1.04e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  19 TPKTKIVCTL-GPASRSVTMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRTAMQNTGILAAVMLDTKGPEIRTGFLKD 97
Cdd:PRK08187  132 ARRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGAVAG 211
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  98 GNPIQ-LKEGQEITITTDYDIKGDEKT---ISMSYKKLPVDVKPGNTILCADGSISLAVVSCDPNAgtVICRCENTAMLG 173
Cdd:PRK08187  212 PLGKTrLYTGDRLALVAQGPPRRIDEEhfqVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGG--ALLEVTHARPKG 289
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 174 ER----KNVNLPGVVVDLPTLTDKDVEDiLKWgVPNNIDMIALSFVRKGSDL------VNVRKVLGSHSKSIMLmsKVEN 243
Cdd:PRK08187  290 LKlkpeKGLNFPDTALDLPALTEKDRAD-LDF-VARHADLVGYSFVQSPGDVealqaaLAARRPDDWRKLGLVL--KIET 365
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 244 QEGVLNFDEIL-----RETDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDV 318
Cdd:PRK08187  366 PRAVANLPELIvqaagRQPFGVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDA 445
                         330
                  ....*....|...
gi 1063743051 319 ANAvlDGTDCVML 331
Cdd:PRK08187  446 AMA--ARAECVML 456
PRK14725 PRK14725
pyruvate kinase; Provisional
28-351 1.17e-34

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 137.39  E-value: 1.17e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  28 LGPASRS------VTM----------IEKLLKAGMNVARFNFSHGSHEYHQETLDNLRTAMQNTGILAAVMLDTKGPEIR 91
Cdd:PRK14725  132 LGPPPSGrptrimVTLpteaaddpdlVRRLLAAGMDIARINCAHDDPEAWRAMIANVRTAEEELGRRCRIAMDLAGPKLR 211
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  92 TGFLKDG------------------------------------------------------------------------- 98
Cdd:PRK14725  212 TGPIAPGprviklrptrdalgrvltparlwltasespppspppgpvglpvdpewlarlepgdelrftdargkkrkltvte 291
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051  99 ---------------------------------------NPIQLKEGQEITITTDyDIKGD-------EKTISMSYKKLP 132
Cdd:PRK14725  292 vddegvlaegsqtaylangtllrlgrhdstrvgglppveQKLRLKVGDRLVLTRD-DAPGDpaqgdapPARISCTLPEAF 370
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 133 VDVKPGNTILCADGSISLAVVSCDPNAGTV-ICRC-ENTAMLGERKNVNLPGVVVDLPTLTDKDVED---ILKWGvpnni 207
Cdd:PRK14725  371 RAARVGERVWFDDGKIGAVVVKVEADEVELrITHArPGGSKLKAGKGINLPDSHLPLPALTDKDLEDlafVAKHA----- 445
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 208 DMIALSFVRKGSDlvnVRKVLGSHSK----SIMLMSKVENQEGVLNFDEILRETDAF-----MVARGDLGMEIPIEKIFL 278
Cdd:PRK14725  446 DIVALSFVRSPED---VRLLLDALEKlgadDLGVVLKIETRRAFENLPRILLEAMRHprfgvMIARGDLAVEVGFERLAE 522
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063743051 279 AQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLdgTDCVMLSgesaAGAYPEIAVKTMAKI 351
Cdd:PRK14725  523 VQEEILWLCEAAHVPVIWATQVLESLAKKGLPSRAEITDAAMALR--AECVMLN----KGPHIVEAVRVLDDI 589
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
380-506 1.39e-25

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 101.02  E-value: 1.39e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743051 380 ESLASSAVRTANKAKAKLIIVLTRGGTTAKLVAKYRPAVPILSVvvpvftsdtfnwsCSDESPARHSLIYRGLIPVLGEg 459
Cdd:pfam02887   1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAV-------------TPNELTARQLALYWGVYPVLFD- 66
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1063743051 460 sakatDSESTEEIIESALKSATEKGLCNHGDAVVALHRI-----GAASVIKI 506
Cdd:pfam02887  67 -----EAETTDEMLRRAVKVAKEAGLVKKGDLVVITAGVpfgvsGTTNTLKV 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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