CCR4-NOT transcription complex subunit 1 is a scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation
CCR4-Not complex component, Not1; The Ccr4-Not complex is a global regulator of transcription ...
1928-2292
2.31e-153
CCR4-Not complex component, Not1; The Ccr4-Not complex is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID.
:
Pssm-ID: 427680 Cd Length: 365 Bit Score: 479.32 E-value: 2.31e-153
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
525-722
3.91e-03
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
The actual alignment was detected with superfamily member pfam03154:
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 42.45 E-value: 3.91e-03
CCR4-Not complex component, Not1; The Ccr4-Not complex is a global regulator of transcription ...
1928-2292
2.31e-153
CCR4-Not complex component, Not1; The Ccr4-Not complex is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID.
Pssm-ID: 427680 Cd Length: 365 Bit Score: 479.32 E-value: 2.31e-153
CCR4-NOT transcription complex subunit 1 CAF1-binding domain; This is the CAF1-binding domain ...
960-1192
3.51e-99
CCR4-NOT transcription complex subunit 1 CAF1-binding domain; This is the CAF1-binding domain of CCR4-NOT transcription complex. It adopts a MIF4G (middle portion of eIF4G) fold.
Pssm-ID: 465111 Cd Length: 225 Bit Score: 318.68 E-value: 3.51e-99
Connector domain of NOT1; This NOT1 connector domain is one of several catalytically inactive ...
1512-1689
5.55e-08
Connector domain of NOT1; This NOT1 connector domain is one of several catalytically inactive subunits of the multisubunit CCR4-NOT complex assembly that plays a central role in post-translational gene regulation in eukaryotes. CCR4-NOT contains the catalytic center formed by two deadenylase subunits CCR4 and CAF1, and the conserved core complex which contains a minimum of four catalytically inactive subunits, NOT1, NOT2, NOT3 and CAF40/NOT9. NOT1 is the largest subunit which functions as a central scaffold for complex assembly in human orthologs. The Chaetomium thermophilum NOT1 connector domain consists of five alpha-helical hairpin repeats of the HEAT type that structurally resemble MIF4G domains, and hence is also called the MIF4G-C domain. However, NOT1 MIF4G-C does not interact with DEAD-box helicases such as DDX6 like MIF4G does. Structural conservation of this domain suggests an important role but its function is as yet unknown.
Pssm-ID: 411008 [Multi-domain] Cd Length: 202 Bit Score: 55.34 E-value: 5.55e-08
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
525-722
3.91e-03
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 42.45 E-value: 3.91e-03
CCR4-Not complex component, Not1; The Ccr4-Not complex is a global regulator of transcription ...
1928-2292
2.31e-153
CCR4-Not complex component, Not1; The Ccr4-Not complex is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID.
Pssm-ID: 427680 Cd Length: 365 Bit Score: 479.32 E-value: 2.31e-153
CCR4-NOT transcription complex subunit 1 CAF1-binding domain; This is the CAF1-binding domain ...
960-1192
3.51e-99
CCR4-NOT transcription complex subunit 1 CAF1-binding domain; This is the CAF1-binding domain of CCR4-NOT transcription complex. It adopts a MIF4G (middle portion of eIF4G) fold.
Pssm-ID: 465111 Cd Length: 225 Bit Score: 318.68 E-value: 3.51e-99
CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819; This is an uncharacterized ...
1299-1447
3.89e-51
CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819; This is an uncharacterized domain that is found on the CCR4-Not complex component Not1. Not1 is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID.
Pssm-ID: 463726 Cd Length: 143 Bit Score: 177.33 E-value: 3.89e-51
CCR4-NOT transcription complex subunit 1 TTP binding domain; This is the TTP binding domain of ...
726-889
1.80e-48
CCR4-NOT transcription complex subunit 1 TTP binding domain; This is the TTP binding domain of CCR4-NOT transcription complex subunit 1. It adopts a MIF4G (middle portion of eIF4G) fold.
Pssm-ID: 465112 Cd Length: 183 Bit Score: 171.63 E-value: 1.80e-48
Connector domain of NOT1; This NOT1 connector domain is one of several catalytically inactive ...
1512-1689
5.55e-08
Connector domain of NOT1; This NOT1 connector domain is one of several catalytically inactive subunits of the multisubunit CCR4-NOT complex assembly that plays a central role in post-translational gene regulation in eukaryotes. CCR4-NOT contains the catalytic center formed by two deadenylase subunits CCR4 and CAF1, and the conserved core complex which contains a minimum of four catalytically inactive subunits, NOT1, NOT2, NOT3 and CAF40/NOT9. NOT1 is the largest subunit which functions as a central scaffold for complex assembly in human orthologs. The Chaetomium thermophilum NOT1 connector domain consists of five alpha-helical hairpin repeats of the HEAT type that structurally resemble MIF4G domains, and hence is also called the MIF4G-C domain. However, NOT1 MIF4G-C does not interact with DEAD-box helicases such as DDX6 like MIF4G does. Structural conservation of this domain suggests an important role but its function is as yet unknown.
Pssm-ID: 411008 [Multi-domain] Cd Length: 202 Bit Score: 55.34 E-value: 5.55e-08
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
525-722
3.91e-03
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 42.45 E-value: 3.91e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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