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Conserved domains on  [gi|1104167536|ref|NP_001334190|]
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leucine-rich repeat transmembrane neuronal protein 4 isoform 4 precursor [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-311 2.11e-26

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 111.95  E-value: 2.11e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536  66 LSLRFNSIQKLKSNQFAGLNQLIWLYLDHNyissvdeDAFQGIRRLKELILSSNKITYLhNKTFHPVPNLRNLDLSYNKL 145
Cdd:COG4886    77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQL 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 146 QTLqSEQFKGLRKLIILHLRSNSLKTVPiRVFQDCRNLDFLDLGYNRLRSLSrnafagllklkelhlehnqfskinfAHF 225
Cdd:COG4886   149 TDL-PEPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-------------------------EPL 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 226 PRLFNLRSIYLQWNRIRSVSQGLTwTWSSLHTLDLSGNDIQAIEpgTFKCLPNLQKLNLDSNKLTNVSQETvnAWISLIS 305
Cdd:COG4886   202 GNLTNLEELDLSGNQLTDLPEPLA-NLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKT 276


                  ....*.
gi 1104167536 306 ITLSGN 311
Cdd:COG4886   277 LDLSNN 282
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-311 2.11e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 111.95  E-value: 2.11e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536  66 LSLRFNSIQKLKSNQFAGLNQLIWLYLDHNyissvdeDAFQGIRRLKELILSSNKITYLhNKTFHPVPNLRNLDLSYNKL 145
Cdd:COG4886    77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQL 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 146 QTLqSEQFKGLRKLIILHLRSNSLKTVPiRVFQDCRNLDFLDLGYNRLRSLSrnafagllklkelhlehnqfskinfAHF 225
Cdd:COG4886   149 TDL-PEPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-------------------------EPL 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 226 PRLFNLRSIYLQWNRIRSVSQGLTwTWSSLHTLDLSGNDIQAIEpgTFKCLPNLQKLNLDSNKLTNVSQETvnAWISLIS 305
Cdd:COG4886   202 GNLTNLEELDLSGNQLTDLPEPLA-NLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKT 276


                  ....*.
gi 1104167536 306 ITLSGN 311
Cdd:COG4886   277 LDLSNN 282
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 90-311 1.12e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 76.36  E-value: 1.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536  90 LYLDHNYISSVDEDAFqgIRRLKELILSSNKITYLHNktFHPVPNLRNLDLSYNKLQTLqsEQFKGLRKLIILHLRSNSl 169
Cdd:cd21340     7 LYLNDKNITKIDNLSL--CKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNR- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 170 ktvpIRV---FQDCRNLDFLDLGYNRLRSlsrnafagllklkelhleHNQFskinfahfprLFNLRSIylqwnriRSVSQ 246
Cdd:cd21340    80 ----ISVvegLENLTNLEELHIENQRLPP------------------GEKL----------TFDPRSL-------AALSN 120

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1104167536 247 gltwtwsSLHTLDLSGNDIQAIEPgtFKCLPNLQKLNLDSNKLTNVSQ--ETVNAWISLISITLSGN 311
Cdd:cd21340   121 -------SLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
133-193 4.32e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.86  E-value: 4.32e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1104167536 133 PNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRL 193
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-311 3.59e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 53.31  E-value: 3.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536  55 IPENISGGSQGLSLRF--NSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPV 132
Cdd:PLN00113  276 IPPSIFSLQKLISLDLsdNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKH 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 133 PNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDfldlgynRLRsLSRNAFAGLLKlkelhl 212
Cdd:PLN00113  356 NNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLR-------RVR-LQDNSFSGELP------ 421

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 213 ehNQFSKINFAHF-------------PRLFNLRSIYLQWNRIRSVSQGLTWTWSS--LHTLDLSGNDIQAIEPGTFKCLP 277
Cdd:PLN00113  422 --SEFTKLPLVYFldisnnnlqgrinSRKWDMPSLQMLSLARNKFFGGLPDSFGSkrLENLDLSRNQFSGAVPRKLGSLS 499

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1104167536 278 NLQKLNLDSNKLTNVSQETVNAWISLISITLSGN 311
Cdd:PLN00113  500 ELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHN 533
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-311 2.11e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 111.95  E-value: 2.11e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536  66 LSLRFNSIQKLKSNQFAGLNQLIWLYLDHNyissvdeDAFQGIRRLKELILSSNKITYLhNKTFHPVPNLRNLDLSYNKL 145
Cdd:COG4886    77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQL 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 146 QTLqSEQFKGLRKLIILHLRSNSLKTVPiRVFQDCRNLDFLDLGYNRLRSLSrnafagllklkelhlehnqfskinfAHF 225
Cdd:COG4886   149 TDL-PEPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-------------------------EPL 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 226 PRLFNLRSIYLQWNRIRSVSQGLTwTWSSLHTLDLSGNDIQAIEpgTFKCLPNLQKLNLDSNKLTNVSQETvnAWISLIS 305
Cdd:COG4886   202 GNLTNLEELDLSGNQLTDLPEPLA-NLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKT 276


                  ....*.
gi 1104167536 306 ITLSGN 311
Cdd:COG4886   277 LDLSNN 282
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-311 5.13e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.85  E-value: 5.13e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536  43 KIVYCESHAFADIPENISGGS--QGLSLRFNSIQKLkSNQFAGLNQLIWLYLDHNYISSVDEdAFQGIRRLKELILSSNK 120
Cdd:COG4886   116 ESLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQ 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 121 ITYLHnKTFHPVPNLRNLDLSYNKLQTLqSEQFKGLRKLIILHLRSNSLKTVPirVFQDCRNLDFLDLGYNRLRSLSrnA 200
Cdd:COG4886   194 ITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLP--P 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 201 FAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSVSQGLTWTWSSLHTLDLSGNDIQAIEPGTFKCLPNLQ 280
Cdd:COG4886   268 LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLL 347

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1104167536 281 KLNLDSNKLTNVSQETVNAWISLISITLSGN 311
Cdd:COG4886   348 ALLTLLLLLNLLSLLLTLLLTLGLLGLLEAT 378
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-311 1.10e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.45  E-value: 1.10e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536  63 SQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSY 142
Cdd:COG4886    26 LLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 143 NklqtlqsEQFKGLRKLIILHLRSNSLKTVPIRvFQDCRNLDFLDLGYNRLRSLSRNafagllklkelhlehnqfskinf 222
Cdd:COG4886   106 N-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEP----------------------- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 223 ahFPRLFNLRSIYLQWNRIRSVSQGLTwTWSSLHTLDLSGNDIQAIePGTFKCLPNLQKLNLDSNKLTNVSQEtVNAWIS 302
Cdd:COG4886   155 --LGNLTNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTN 229


                  ....*....
gi 1104167536 303 LISITLSGN 311
Cdd:COG4886   230 LETLDLSNN 238
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 90-311 1.12e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 76.36  E-value: 1.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536  90 LYLDHNYISSVDEDAFqgIRRLKELILSSNKITYLHNktFHPVPNLRNLDLSYNKLQTLqsEQFKGLRKLIILHLRSNSl 169
Cdd:cd21340     7 LYLNDKNITKIDNLSL--CKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNR- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 170 ktvpIRV---FQDCRNLDFLDLGYNRLRSlsrnafagllklkelhleHNQFskinfahfprLFNLRSIylqwnriRSVSQ 246
Cdd:cd21340    80 ----ISVvegLENLTNLEELHIENQRLPP------------------GEKL----------TFDPRSL-------AALSN 120

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1104167536 247 gltwtwsSLHTLDLSGNDIQAIEPgtFKCLPNLQKLNLDSNKLTNVSQ--ETVNAWISLISITLSGN 311
Cdd:cd21340   121 -------SLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
133-193 4.32e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.86  E-value: 4.32e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1104167536 133 PNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRL 193
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-265 1.82e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.74  E-value: 1.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536  43 KIVYCESHAFADIPENISGGS--QGLSLRFNSIQKLkSNQFAGLNQLIWLYLDHNYISSVDEDaFQGIRRLKELILSSNK 120
Cdd:COG4886   162 KSLDLSNNQLTDLPEELGNLTnlKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQ 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 121 ITYLHNktFHPVPNLRNLDLSYNKLQTLQSEqfKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNA 200
Cdd:COG4886   240 LTDLPE--LGNLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1104167536 201 FAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSVSQGLTWTWSSLHTLDLSGNDI 265
Cdd:COG4886   316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLL 380
LRR_8 pfam13855
Leucine rich repeat;
86-145 8.91e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.01  E-value: 8.91e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536  86 QLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKL 145
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
66-121 3.37e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 3.37e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1104167536  66 LSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKI 121
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
109-169 6.67e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 6.67e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1104167536 109 RRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSL 169
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
230-289 3.95e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 3.95e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 230 NLRSIYLQWNRIRSVSQGLTWTWSSLHTLDLSGNDIQAIEPGTFKCLPNLQKLNLDSNKL 289
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
253-311 1.60e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 1.60e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1104167536 253 SSLHTLDLSGNDIQAIEPGTFKCLPNLQKLNLDSNKLTNVSQetvNAWI---SLISITLSGN 311
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSP---GAFSglpSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
157-241 4.53e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 4.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 157 RKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGllklkelhlehnqfskinfahfprLFNLRSIYL 236
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG------------------------LPSLRYLDL 56


                  ....*
gi 1104167536 237 QWNRI 241
Cdd:pfam13855  57 SGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 71-268 9.33e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.87  E-value: 9.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536  71 NSIQKLKsnQFAGLNQLIWLYLDHNYISSVDEdaFQGIRRLKELILSSNKITYLHNktFHPVPNLRNLDLSYnklQTLQS 150
Cdd:cd21340    34 NKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIEN---QRLPP 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 151 EQFkglrkliiLHLRSNSLKTVpirvfqdCRNLDFLDLGYNRLRSLSrnafagllklkelhlehnqfskiNFAHfprLFN 230
Cdd:cd21340   105 GEK--------LTFDPRSLAAL-------SNSLRVLNISGNNIDSLE-----------------------PLAP---LRN 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1104167536 231 LRSIYLQWNRIRSVSQgLTWT---WSSLHTLDLSGNDIQAI 268
Cdd:cd21340   144 LEQLDASNNQISDLEE-LLDLlssWPSLRELDLTGNPVCKK 183
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-311 3.59e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 53.31  E-value: 3.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536  55 IPENISGGSQGLSLRF--NSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPV 132
Cdd:PLN00113  276 IPPSIFSLQKLISLDLsdNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKH 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 133 PNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDfldlgynRLRsLSRNAFAGLLKlkelhl 212
Cdd:PLN00113  356 NNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLR-------RVR-LQDNSFSGELP------ 421

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 213 ehNQFSKINFAHF-------------PRLFNLRSIYLQWNRIRSVSQGLTWTWSS--LHTLDLSGNDIQAIEPGTFKCLP 277
Cdd:PLN00113  422 --SEFTKLPLVYFldisnnnlqgrinSRKWDMPSLQMLSLARNKFFGGLPDSFGSkrLENLDLSRNQFSGAVPRKLGSLS 499

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1104167536 278 NLQKLNLDSNKLTNVSQETVNAWISLISITLSGN 311
Cdd:PLN00113  500 ELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHN 533
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 84-295 3.77e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 52.36  E-value: 3.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536  84 LNQLIWLYLDHNYISSVDEDAFQGIRR---LKELILSSNKITYLHNKTF-----HPVPNLRNLDLSYNKLQTLQSEQ--- 152
Cdd:cd00116    80 GCGLQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNGLGDRGLRLLakglkDLPPALEKLVLGRNRLEGASCEAlak 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 153 -FKGLRKLIILHLRSNSLKTVPIRV----FQDCRNLDFLDLGYNRLRSLSRNAFAGLlklkelhlehnqfskinfahFPR 227
Cdd:cd00116   160 aLRANRDLKELNLANNGIGDAGIRAlaegLKANCNLEVLDLNNNGLTDEGASALAET--------------------LAS 219

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1104167536 228 LFNLRSIYLQWNRIRSV-----SQGLTWTWSSLHTLDLSGNDI------QAIEPGTFKCLpnLQKLNLDSNKLTNVSQE 295
Cdd:cd00116   220 LKSLEVLNLGDNNLTDAgaaalASALLSPNISLLTLSLSCNDItddgakDLAEVLAEKES--LLELDLRGNKFGEEGAQ 296
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 133-297 2.14e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.05  E-value: 2.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 133 PNLRNLDLSYNKLQTLQSEQFKGLRK---LIILHLRSNSL-----KTVpIRVFQDCR-NLDFLDLGYNRLRSLSRNAFAG 203
Cdd:cd00116    81 CGLQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNGLgdrglRLL-AKGLKDLPpALEKLVLGRNRLEGASCEALAK 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 204 LLKLKEL----HLEHNQFSKINFAH----FPRLFNLRSIYLQWNRIRS-----VSQGLTwTWSSLHTLDLSGN-----DI 265
Cdd:cd00116   160 ALRANRDlkelNLANNGIGDAGIRAlaegLKANCNLEVLDLNNNGLTDegasaLAETLA-SLKSLEVLNLGDNnltdaGA 238

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1104167536 266 QAIEPGTFKCLPNLQKLNLDSNKLTNVSQETV 297
Cdd:cd00116   239 AALASALLSPNISLLTLSLSCNDITDDGAKDL 270
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 61-311 3.46e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.79  E-value: 3.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536  61 GGSQGLSLRFNSIQKLKSNQFAGLNQLIWL---YLDHNYISSvdedafQGIRRLKE----------LILSSNKITYL--- 124
Cdd:COG5238   153 GNAVHLLGLAARLGLLAAISMAKALQNNSVetvYLGCNQIGD------EGIEELAEaltqnttvttLWLKRNPIGDEgae 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 125 -------HNKTfhpvpnLRNLDLSYNKLqtlqseqfkGLRKLIIL--HLRSNslktvpirvfqdcRNLDFLDLGYNRL-- 193
Cdd:COG5238   227 ilaealkGNKS------LTTLDLSNNQI---------GDEGVIALaeALKNN-------------TTVETLYLSGNQIga 278

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 194 ---RSLSrNAFAGLLKLKELHLEHNQF---SKINFA-HFPRLFNLRSIYLQWNRI-----RSVSQGLtWTWSSLHTLDLS 261
Cdd:COG5238   279 egaIALA-KALQGNTTLTSLDLSVNRIgdeGAIALAeGLQGNKTLHTLNLAYNGIgaqgaIALAKAL-QENTTLHSLDLS 356

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1104167536 262 GN---DIQAIEPGTF-KCLPNLQKLNLDSNKLTNVSQETVNAWI---SLISITLSGN 311
Cdd:COG5238   357 DNqigDEGAIALAKYlEGNTTLRELNLGKNNIGKQGAEALIDALqtnRLHTLILDGN 413
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
86-294 5.96e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 49.31  E-value: 5.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536  86 QLIWLYLDHNYISSVDEDaFQGirRLKELILSSNKITYLHNKtfhpVPN-LRNLDLSYNKLQTLQSEQFKGLRKLIILHl 164
Cdd:PRK15370  200 QITTLILDNNELKSLPEN-LQG--NIKTLYANSNQLTSIPAT----LPDtIQEMELSINRITELPERLPSALQSLDLFH- 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 165 rsNSLKTVPIRVFQDCRNLDFLDlgyNRLRSLSRNAFAGLLKLkelhlehNQFSKiNFAHFPRLF--NLRSIYLQWNRIR 242
Cdd:PRK15370  272 --NKISCLPENLPEELRYLSVYD---NSIRTLPAHLPSGITHL-------NVQSN-SLTALPETLppGLKTLEAGENALT 338

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1104167536 243 SVSQGLTwtwSSLHTLDLSGNDIQAIePGTFKclPNLQKLNLDSNKLTNVSQ 294
Cdd:PRK15370  339 SLPASLP---PELQVLDVSKNQITVL-PETLP--PTITTLDVSRNALTNLPE 384
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 57-311 1.72e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 1.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536  57 ENISGGSQGLSLRFNSIQ--KLKSNQFAGlnqliwlyldhnyisSVDEDAFQGIRRLKELILSSNKITYLHNKTFhpVPN 134
Cdd:PLN00113   79 KNISGKISSAIFRLPYIQtiNLSNNQLSG---------------PIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPN 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 135 LRNLDLSYNKLQtlqseqfkglrkliilhlrsnslKTVP--IRVFQdcrNLDFLDLGYNRLRSLSRNAFAGLLKLKELHL 212
Cdd:PLN00113  142 LETLDLSNNMLS-----------------------GEIPndIGSFS---SLKVLDLGGNVLVGKIPNSLTNLTSLEFLTL 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 213 EHNQFSKINFAHFPRLFNLRSIYLQWNRIRSVSQGLTWTWSSLHTLDLSGNDIQAIEPGTFKCLPNLQKLNLDSNKLTNV 292
Cdd:PLN00113  196 ASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGP 275

                         250
                  ....*....|....*....
gi 1104167536 293 SQETVNAWISLISITLSGN 311
Cdd:PLN00113  276 IPPSIFSLQKLISLDLSDN 294
LRR_9 pfam14580
Leucine-rich repeat;
66-185 2.90e-05

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 44.75  E-value: 2.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536  66 LSLRFNSIQKLKsNQFAGLNQLIWLYLDHNYISSVDedAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKL 145
Cdd:pfam14580  24 LDLRGYKIPIIE-NLGATLDQFDTIDFSDNEIRKLD--GFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNL 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1104167536 146 QTL-QSEQFKGLRKLIILHLRSNSLKTVP------IRVFQDCRNLDF 185
Cdd:pfam14580 101 QELgDLDPLASLKKLTFLSLLRNPVTNKPhyrlyvIYKVPQLRLLDF 147
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 76-193 1.46e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536  76 LKSNQFAG--------LNQLIWLYLDHNYISSVDEDAFqGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQT 147
Cdd:PLN00113  435 ISNNNLQGrinsrkwdMPSLQMLSLARNKFFGGLPDSF-GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSG 513

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1104167536 148 LQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRL 193
Cdd:PLN00113  514 EIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 254-293 1.71e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 1.71e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1104167536 254 SLHTLDLSGNDIQAIEPgtFKCLPNLQKLNLDSN-KLTNVS 293
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNnKITDLS 40
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 95-183 1.15e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.07  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536  95 NYISSVDEDAFQGIRRLKELILSSN---------------------KITYLHNKTFHPVPNLRNLDLSyNKLQTLQSEQF 153
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLPSSltsigsyafyncsltsitipsSLTSIGEYAFSNCSNLKSITLP-SNLTSIGSYAF 98

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1104167536 154 KG--LRKLIIlhlrSNSLKTVPIRVFQDCRNL 183
Cdd:pfam13306  99 SNcsLKSITI----PSSVTTIGSYAFSNCSNL 126
LRR_9 pfam14580
Leucine-rich repeat;
215-291 1.48e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 39.75  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536 215 NQFSKINFA--------HFPRLFNLRSIYLQWNRIRSVSQGLTWTWSSLHTLDLSGNDIQA---IEPgtFKCLPNLQKLN 283
Cdd:pfam14580  42 DQFDTIDFSdneirkldGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQElgdLDP--LASLKKLTFLS 119


                  ....*...
gi 1104167536 284 LDSNKLTN 291
Cdd:pfam14580 120 LLRNPVTN 127
PLN03150 PLN03150
hypothetical protein; Provisional
 226-290 1.54e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.34  E-value: 1.54e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1104167536 226 PRLFNLRSIYLQWNRIRSVSQGLTWTWSSLHTLDLSGNDIQAIEPGTFKCLPNLQKLNLDSNKLT 290
Cdd:PLN03150  439 SKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS 503
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 133-167 4.41e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 4.41e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1104167536 133 PNLRNLDLSYNKLQTLQSeqFKGLRKLIILHLRSN 167
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLSGN 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 66-145 6.75e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.45  E-value: 6.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104167536  66 LSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKL 145
Cdd:PLN00113  480 LDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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