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Conserved domains on  [gi|1121393408|ref|NP_001334831|]
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refilin-A [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FAM101 super family cl20939
FAM101 family; This protein family includes the actin regulators, Refilin A and B, however the ...
 1-122 5.93e-77

FAM101 family; This protein family includes the actin regulators, Refilin A and B, however the exact function of this protein family remains unknown. Refilin is thought to stabilize peri-nuclear actin filament bundles, important in fibroblasts. Refilin is important as changes in localization and shape in the nucleus plays a role in cellular and developmental processes.


The actual alignment was detected with superfamily member pfam15068:

Pssm-ID: 464483  Cd Length: 208  Bit Score: 226.51  E-value: 5.93e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121393408   1 MRPRMLPVFFGESIKVNPEPTHEIRCNSEVKYASEKHFQDKVFYAPVP-TVTAYSETIVAAPNCTWRNYRSQLTLEPRPR 79
Cdd:pfam15068  86 CRPRLCPLSFGEGIEVDPLPPKEIRYTSSVKYDSERHFIDDVYLAPVGlTVTSCSQTVVAVPNCTWRNYKTQLHFEPRQR 165

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1121393408  80 ALRFRSTTIIFPKHARSTFRTTLHCSLGRPSRWFTASVQLQLC 122
Cdd:pfam15068 166 PLRFQSTTIIYPKHAKNVYTTTLNYNCRRLLRRFLSSVELEAS 208
 
Name Accession Description Interval E-value
FAM101 pfam15068
FAM101 family; This protein family includes the actin regulators, Refilin A and B, however the ...
 1-122 5.93e-77

FAM101 family; This protein family includes the actin regulators, Refilin A and B, however the exact function of this protein family remains unknown. Refilin is thought to stabilize peri-nuclear actin filament bundles, important in fibroblasts. Refilin is important as changes in localization and shape in the nucleus plays a role in cellular and developmental processes.


Pssm-ID: 464483  Cd Length: 208  Bit Score: 226.51  E-value: 5.93e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121393408   1 MRPRMLPVFFGESIKVNPEPTHEIRCNSEVKYASEKHFQDKVFYAPVP-TVTAYSETIVAAPNCTWRNYRSQLTLEPRPR 79
Cdd:pfam15068  86 CRPRLCPLSFGEGIEVDPLPPKEIRYTSSVKYDSERHFIDDVYLAPVGlTVTSCSQTVVAVPNCTWRNYKTQLHFEPRQR 165

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1121393408  80 ALRFRSTTIIFPKHARSTFRTTLHCSLGRPSRWFTASVQLQLC 122
Cdd:pfam15068 166 PLRFQSTTIIYPKHAKNVYTTTLNYNCRRLLRRFLSSVELEAS 208
 
Name Accession Description Interval E-value
FAM101 pfam15068
FAM101 family; This protein family includes the actin regulators, Refilin A and B, however the ...
 1-122 5.93e-77

FAM101 family; This protein family includes the actin regulators, Refilin A and B, however the exact function of this protein family remains unknown. Refilin is thought to stabilize peri-nuclear actin filament bundles, important in fibroblasts. Refilin is important as changes in localization and shape in the nucleus plays a role in cellular and developmental processes.


Pssm-ID: 464483  Cd Length: 208  Bit Score: 226.51  E-value: 5.93e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121393408   1 MRPRMLPVFFGESIKVNPEPTHEIRCNSEVKYASEKHFQDKVFYAPVP-TVTAYSETIVAAPNCTWRNYRSQLTLEPRPR 79
Cdd:pfam15068  86 CRPRLCPLSFGEGIEVDPLPPKEIRYTSSVKYDSERHFIDDVYLAPVGlTVTSCSQTVVAVPNCTWRNYKTQLHFEPRQR 165

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1121393408  80 ALRFRSTTIIFPKHARSTFRTTLHCSLGRPSRWFTASVQLQLC 122
Cdd:pfam15068 166 PLRFQSTTIIYPKHAKNVYTTTLNYNCRRLLRRFLSSVELEAS 208
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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