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Conserved domains on  [gi|1143076933|ref|NP_001335032|]
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bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1 [Mus musculus]

Protein Classification

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase( domain architecture ID 10572471)

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
HSNSD pfam12062
heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase ...
 81-515 0e+00

heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes. This proteinenzyme is often found associated with pfam00685.


:

Pssm-ID: 463450  Cd Length: 429  Bit Score: 921.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076933  81 TDPLVLVFVESLYSQLGQEVVAILESSRFKYRTEIApgKGDMPTLTDKGRGRFALIIYENILKYVNLDAWNRELLDKYCV 160
Cdd:pfam12062   1 TDPKVLVFVESLYSQLGQEIIAILESNRFKYKTEIA--KKDLPVLTNKDKGRYSLIIYENYLKYLNMDKWNRELLDKYCR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076933 161 AYGVGIIGFFKANENSLLSAQLKGFPLFLHSNLGLKDCSINPKSPLLYVTRPSEVEKGVLPGEDWTVFQSNHSTYEPVLL 240
Cdd:pfam12062  79 EYGVGIIGFFKANENSLLSAQLKGFPLFLHTNLRLKDCTVNPKSPLLRITRPGEVEQGPLPGDDWTVFQSNHSTYEPVLL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076933 241 AKTRSSESIPHLGadagLHAALHATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFVDAVAFLTGKRLSLPLDRYILVDIDD 320
Cdd:pfam12062 159 AKVKSGEESPSPG----LDAALLATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFLDALSYLTGKRLSLSLDRYILVDIDD 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076933 321 IFVGKEGTRMKVEDVKALFDTQNELRTHIPNFTFNLGYSGKFFHTGTDAEDAGDDLLLSYVKEFWWFPHMWSHMQPHLFH 400
Cdd:pfam12062 235 IFVGKEGTRMKVEDVKALLETQNRLRTLVPNFTFNLGFSGKYFHNGTDEEDEGDDLLLENVKEFWWFPHMWSHMQPHLFH 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076933 401 NQSVLAEQMALNKKFAVEHGIPTDMGYAVAPHHSGVYPVHVQLYEAWKQVWGIRVTSTEEYPHLKPARYRRGFIHNGIMV 480
Cdd:pfam12062 315 NQTVLEEQMLLNKKFAQEHGIPTDSGYAVAPHHSGVYPVHEQLYEAWKKVWNIKVTSTEEYPHLKPARLRRGFIHRGIMV 394

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1143076933 481 LPRQTCGLFTHTIFYNEYPGGSSELDKIINGGELF 515
Cdd:pfam12062 395 LPRQTCGLFTHTIFYDEYPGGPKKLDKSIQGGELF 429
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
605-855 1.88e-44

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 160.97  E-value: 1.88e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076933 605 PKLLIIGPQKTGTTALYLFLGMHPDLSSNypssETFEEIQFFNGHNYHKGIDWYmeffpipsnttsdfyfeKSANYFDSE 684
Cdd:pfam00685   2 DDVLIVTYPKSGTTWLQEILSLIPNRGDF----EKSEEPHLFNNHNRSPFLEWY-----------------PGDTYFDVA 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076933 685 VAPRRAAAL--------------------LPKAKILSILINPADRAYSWYQHQRAHDDPVALKYTFHEVitagpdasskl 744
Cdd:pfam00685  61 EGPVRLNALpspriikthlplhllpkslwDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFV----------- 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076933 745 RALQNRCLVPGWYATHIERWLSAFHANQILVLDGKLLRTEPAKVMDTVQKFLGVTST----VDYHKTLAFDPKKGFWCQL 820
Cdd:pfam00685 130 EDFLNGKVNCGSYFDHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTeeelDKIVKHLSFENMKGNPCLN 209

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1143076933 821 L-------EGGKTKCLGKSkgrKYPEMDLDSRAFLKDYFRDH 855
Cdd:pfam00685 210 YsklpkevSPFFRKGLVGD---WKNYFTPEQAEKFDEIYQEK 248
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 38-83 6.61e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 6.61e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1143076933   38 LYGWNRGLEPSAdasESDCGDPPPVAPSRLLPIKPVQAVAPSRTDP 83
Cdd:PHA03247  2533 MLTWIRGLEELA---SDDAGDPPPPLPPAAPPAAPDRSVPPPRPAP 2575
 
Name Accession Description Interval E-value
HSNSD pfam12062
heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase ...
 81-515 0e+00

heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes. This proteinenzyme is often found associated with pfam00685.


Pssm-ID: 463450  Cd Length: 429  Bit Score: 921.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076933  81 TDPLVLVFVESLYSQLGQEVVAILESSRFKYRTEIApgKGDMPTLTDKGRGRFALIIYENILKYVNLDAWNRELLDKYCV 160
Cdd:pfam12062   1 TDPKVLVFVESLYSQLGQEIIAILESNRFKYKTEIA--KKDLPVLTNKDKGRYSLIIYENYLKYLNMDKWNRELLDKYCR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076933 161 AYGVGIIGFFKANENSLLSAQLKGFPLFLHSNLGLKDCSINPKSPLLYVTRPSEVEKGVLPGEDWTVFQSNHSTYEPVLL 240
Cdd:pfam12062  79 EYGVGIIGFFKANENSLLSAQLKGFPLFLHTNLRLKDCTVNPKSPLLRITRPGEVEQGPLPGDDWTVFQSNHSTYEPVLL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076933 241 AKTRSSESIPHLGadagLHAALHATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFVDAVAFLTGKRLSLPLDRYILVDIDD 320
Cdd:pfam12062 159 AKVKSGEESPSPG----LDAALLATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFLDALSYLTGKRLSLSLDRYILVDIDD 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076933 321 IFVGKEGTRMKVEDVKALFDTQNELRTHIPNFTFNLGYSGKFFHTGTDAEDAGDDLLLSYVKEFWWFPHMWSHMQPHLFH 400
Cdd:pfam12062 235 IFVGKEGTRMKVEDVKALLETQNRLRTLVPNFTFNLGFSGKYFHNGTDEEDEGDDLLLENVKEFWWFPHMWSHMQPHLFH 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076933 401 NQSVLAEQMALNKKFAVEHGIPTDMGYAVAPHHSGVYPVHVQLYEAWKQVWGIRVTSTEEYPHLKPARYRRGFIHNGIMV 480
Cdd:pfam12062 315 NQTVLEEQMLLNKKFAQEHGIPTDSGYAVAPHHSGVYPVHEQLYEAWKKVWNIKVTSTEEYPHLKPARLRRGFIHRGIMV 394

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1143076933 481 LPRQTCGLFTHTIFYNEYPGGSSELDKIINGGELF 515
Cdd:pfam12062 395 LPRQTCGLFTHTIFYDEYPGGPKKLDKSIQGGELF 429
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
605-855 1.88e-44

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 160.97  E-value: 1.88e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076933 605 PKLLIIGPQKTGTTALYLFLGMHPDLSSNypssETFEEIQFFNGHNYHKGIDWYmeffpipsnttsdfyfeKSANYFDSE 684
Cdd:pfam00685   2 DDVLIVTYPKSGTTWLQEILSLIPNRGDF----EKSEEPHLFNNHNRSPFLEWY-----------------PGDTYFDVA 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076933 685 VAPRRAAAL--------------------LPKAKILSILINPADRAYSWYQHQRAHDDPVALKYTFHEVitagpdasskl 744
Cdd:pfam00685  61 EGPVRLNALpspriikthlplhllpkslwDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFV----------- 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076933 745 RALQNRCLVPGWYATHIERWLSAFHANQILVLDGKLLRTEPAKVMDTVQKFLGVTST----VDYHKTLAFDPKKGFWCQL 820
Cdd:pfam00685 130 EDFLNGKVNCGSYFDHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTeeelDKIVKHLSFENMKGNPCLN 209

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1143076933 821 L-------EGGKTKCLGKSkgrKYPEMDLDSRAFLKDYFRDH 855
Cdd:pfam00685 210 YsklpkevSPFFRKGLVGD---WKNYFTPEQAEKFDEIYQEK 248
PHA03247 PHA03247
large tegument protein UL36; Provisional
 38-83 6.61e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 6.61e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1143076933   38 LYGWNRGLEPSAdasESDCGDPPPVAPSRLLPIKPVQAVAPSRTDP 83
Cdd:PHA03247  2533 MLTWIRGLEELA---SDDAGDPPPPLPPAAPPAAPDRSVPPPRPAP 2575
 
Name Accession Description Interval E-value
HSNSD pfam12062
heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase ...
 81-515 0e+00

heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes. This proteinenzyme is often found associated with pfam00685.


Pssm-ID: 463450  Cd Length: 429  Bit Score: 921.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076933  81 TDPLVLVFVESLYSQLGQEVVAILESSRFKYRTEIApgKGDMPTLTDKGRGRFALIIYENILKYVNLDAWNRELLDKYCV 160
Cdd:pfam12062   1 TDPKVLVFVESLYSQLGQEIIAILESNRFKYKTEIA--KKDLPVLTNKDKGRYSLIIYENYLKYLNMDKWNRELLDKYCR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076933 161 AYGVGIIGFFKANENSLLSAQLKGFPLFLHSNLGLKDCSINPKSPLLYVTRPSEVEKGVLPGEDWTVFQSNHSTYEPVLL 240
Cdd:pfam12062  79 EYGVGIIGFFKANENSLLSAQLKGFPLFLHTNLRLKDCTVNPKSPLLRITRPGEVEQGPLPGDDWTVFQSNHSTYEPVLL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076933 241 AKTRSSESIPHLGadagLHAALHATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFVDAVAFLTGKRLSLPLDRYILVDIDD 320
Cdd:pfam12062 159 AKVKSGEESPSPG----LDAALLATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFLDALSYLTGKRLSLSLDRYILVDIDD 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076933 321 IFVGKEGTRMKVEDVKALFDTQNELRTHIPNFTFNLGYSGKFFHTGTDAEDAGDDLLLSYVKEFWWFPHMWSHMQPHLFH 400
Cdd:pfam12062 235 IFVGKEGTRMKVEDVKALLETQNRLRTLVPNFTFNLGFSGKYFHNGTDEEDEGDDLLLENVKEFWWFPHMWSHMQPHLFH 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076933 401 NQSVLAEQMALNKKFAVEHGIPTDMGYAVAPHHSGVYPVHVQLYEAWKQVWGIRVTSTEEYPHLKPARYRRGFIHNGIMV 480
Cdd:pfam12062 315 NQTVLEEQMLLNKKFAQEHGIPTDSGYAVAPHHSGVYPVHEQLYEAWKKVWNIKVTSTEEYPHLKPARLRRGFIHRGIMV 394

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1143076933 481 LPRQTCGLFTHTIFYNEYPGGSSELDKIINGGELF 515
Cdd:pfam12062 395 LPRQTCGLFTHTIFYDEYPGGPKKLDKSIQGGELF 429
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
605-855 1.88e-44

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 160.97  E-value: 1.88e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076933 605 PKLLIIGPQKTGTTALYLFLGMHPDLSSNypssETFEEIQFFNGHNYHKGIDWYmeffpipsnttsdfyfeKSANYFDSE 684
Cdd:pfam00685   2 DDVLIVTYPKSGTTWLQEILSLIPNRGDF----EKSEEPHLFNNHNRSPFLEWY-----------------PGDTYFDVA 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076933 685 VAPRRAAAL--------------------LPKAKILSILINPADRAYSWYQHQRAHDDPVALKYTFHEVitagpdasskl 744
Cdd:pfam00685  61 EGPVRLNALpspriikthlplhllpkslwDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFV----------- 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076933 745 RALQNRCLVPGWYATHIERWLSAFHANQILVLDGKLLRTEPAKVMDTVQKFLGVTST----VDYHKTLAFDPKKGFWCQL 820
Cdd:pfam00685 130 EDFLNGKVNCGSYFDHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTeeelDKIVKHLSFENMKGNPCLN 209

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1143076933 821 L-------EGGKTKCLGKSkgrKYPEMDLDSRAFLKDYFRDH 855
Cdd:pfam00685 210 YsklpkevSPFFRKGLVGD---WKNYFTPEQAEKFDEIYQEK 248
Sulfotransfer_3 pfam13469
Sulfotransferase family;
607-799 4.17e-09

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 56.53  E-value: 4.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076933 607 LLIIGPQKTGTTALYLFLGMHPDLSSNYpssETFEEIQFFNGHnYHKGIDWYMEFFPIPSNTtsDFYFEKSANYFdseVA 686
Cdd:pfam13469   1 IFIVGLPRSGTTLLHRLLAAHPDVRPPE---ETWFVIPRILAL-LQAWGKSLEALARVPSYA--RWLCDKSPSHL---FH 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076933 687 PRRAAALLPKAKILSILINPADRAYSWYQHQRAHDdpvALKYTFHEVITAGPDASsklralqnrclvpgWYATHIERWLS 766
Cdd:pfam13469  72 LDLLLKAFPDAKFIHLHRDPVDTVISSYCSLFGFT---LSSYSTAFLRDIGLALA--------------RWSRAYERLMA 134

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1143076933 767 A---FHANQILVLDGKLLRTEPAKVMDTVQKFLGVT 799
Cdd:pfam13469 135 ArarVPPGRFLDVRYEDLVADPEGTLRRILEFLGLP 170
PHA03247 PHA03247
large tegument protein UL36; Provisional
 38-83 6.61e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 6.61e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1143076933   38 LYGWNRGLEPSAdasESDCGDPPPVAPSRLLPIKPVQAVAPSRTDP 83
Cdd:PHA03247  2533 MLTWIRGLEELA---SDDAGDPPPPLPPAAPPAAPDRSVPPPRPAP 2575
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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