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Conserved domains on  [gi|1143076937|ref|NP_001335034|]
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guanine nucleotide-binding protein subunit beta-4 isoform 2 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-304 3.92e-83

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 252.26  E-value: 3.92e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937  12 RRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLK 91
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937  92 TREgnvrVSRELPGHTGYLSCCRFLDDGQIITSSG-DTTCALWDIETGQQTTTFTGHSGDVMSLSLSPDlKTFVSGAC-D 169
Cdd:cd00200    82 TGE----CVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSqD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937 170 ASSKLWDIRDGMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFDLRADQEL-LLYSHDNIICgitSVAFSKSGRL 248
Cdd:cd00200   157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLgTLRGHENGVN---SVAFSPDGYL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1143076937 249 LLAGYDDFNCSVWDALKGGRSGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 304
Cdd:cd00200   234 LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-304 3.92e-83

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 252.26  E-value: 3.92e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937  12 RRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLK 91
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937  92 TREgnvrVSRELPGHTGYLSCCRFLDDGQIITSSG-DTTCALWDIETGQQTTTFTGHSGDVMSLSLSPDlKTFVSGAC-D 169
Cdd:cd00200    82 TGE----CVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSqD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937 170 ASSKLWDIRDGMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFDLRADQEL-LLYSHDNIICgitSVAFSKSGRL 248
Cdd:cd00200   157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLgTLRGHENGVN---SVAFSPDGYL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1143076937 249 LLAGYDDFNCSVWDALKGGRSGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 304
Cdd:cd00200   234 LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
10-304 1.35e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 198.21  E-value: 1.35e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937  10 RTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 89
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937  90 LKTRegnvRVSRELPGHTGYLSCCRFLDDGQII-TSSGDTTCALWDIETGQQTTTFTGHSGDVMSLSLSPDLKTFVSGAC 168
Cdd:COG2319   191 LATG----KLLRTLTGHTGAVRSVAFSPDGKLLaSGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937 169 DASSKLWDIRDGMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFDLRADQelLLYSHDNIICGITSVAFSKSGRL 248
Cdd:COG2319   267 DGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFSPDGKT 344

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1143076937 249 LLAGYDDFNCSVWDALKGGRSGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 304
Cdd:COG2319   345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 4-135 7.36e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.47  E-value: 7.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937   4 VGRIQMRTRrtLRGHLAKIYAMHWGY-DSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSwvMTCAYAPS--GNYVACGG 80
Cdd:PLN00181  562 VARSQLVTE--MKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN--ICCVQFPSesGRSLAFGS 637

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937  81 LDNICSIYNLKtregnvrvSRELP-----GHTGYLSCCRFLDDGQIITSSGDTTCALWDI 135
Cdd:PLN00181  638 ADHKVYYYDLR--------NPKLPlctmiGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 179-218 9.47e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 9.47e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1143076937  179 DGMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFD 218
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
180-218 5.27e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 5.27e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1143076937 180 GMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFD 218
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-304 3.92e-83

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 252.26  E-value: 3.92e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937  12 RRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLK 91
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937  92 TREgnvrVSRELPGHTGYLSCCRFLDDGQIITSSG-DTTCALWDIETGQQTTTFTGHSGDVMSLSLSPDlKTFVSGAC-D 169
Cdd:cd00200    82 TGE----CVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSqD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937 170 ASSKLWDIRDGMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFDLRADQEL-LLYSHDNIICgitSVAFSKSGRL 248
Cdd:cd00200   157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLgTLRGHENGVN---SVAFSPDGYL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1143076937 249 LLAGYDDFNCSVWDALKGGRSGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 304
Cdd:cd00200   234 LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
10-304 1.35e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 198.21  E-value: 1.35e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937  10 RTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 89
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937  90 LKTRegnvRVSRELPGHTGYLSCCRFLDDGQII-TSSGDTTCALWDIETGQQTTTFTGHSGDVMSLSLSPDLKTFVSGAC 168
Cdd:COG2319   191 LATG----KLLRTLTGHTGAVRSVAFSPDGKLLaSGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937 169 DASSKLWDIRDGMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFDLRADQelLLYSHDNIICGITSVAFSKSGRL 248
Cdd:COG2319   267 DGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFSPDGKT 344

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1143076937 249 LLAGYDDFNCSVWDALKGGRSGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 304
Cdd:COG2319   345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
10-304 4.95e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.28  E-value: 4.95e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937  10 RTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 89
Cdd:COG2319    69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937  90 LKTRegnvRVSRELPGHTGYLSCCRFLDDGQII-TSSGDTTCALWDIETGQQTTTFTGHSGDVMSLSLSPDLKTFVSGAC 168
Cdd:COG2319   149 LATG----KLLRTLTGHSGAVTSVAFSPDGKLLaSGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSA 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937 169 DASSKLWDIRDGMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFDLRADQELLLYSHDNiiCGITSVAFSKSGRL 248
Cdd:COG2319   225 DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHS--GGVNSVAFSPDGKL 302

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1143076937 249 LLAGYDDFNCSVWDALKGGRSGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 304
Cdd:COG2319   303 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
10-263 3.89e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.56  E-value: 3.89e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937  10 RTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 89
Cdd:COG2319   153 KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937  90 LKTREgnvrVSRELPGHTGYLSCCRFLDDGQII-TSSGDTTCALWDIETGQQTTTFTGHSGDVMSLSLSPDLKTFVSGAC 168
Cdd:COG2319   233 LATGK----LLRTLTGHSGSVRSVAFSPDGRLLaSGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSD 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937 169 DASSKLWDIRDGMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFDLRADQELL-LYSHDNiicGITSVAFSKSGR 247
Cdd:COG2319   309 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRtLTGHTG---AVTSVAFSPDGR 385

                         250
                  ....*....|....*.
gi 1143076937 248 LLLAGYDDFNCSVWDA 263
Cdd:COG2319   386 TLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
10-220 7.40e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.21  E-value: 7.40e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937  10 RTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 89
Cdd:COG2319   195 KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937  90 LKTREgnvrVSRELPGHTGYLSCCRFLDDGQ-IITSSGDTTCALWDIETGQQTTTFTGHSGDVMSLSLSPDLKTFVSGAC 168
Cdd:COG2319   275 LATGE----LLRTLTGHSGGVNSVAFSPDGKlLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSD 350

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1143076937 169 DASSKLWDIRDGMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFDLR 220
Cdd:COG2319   351 DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
90-304 2.78e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.57  E-value: 2.78e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937  90 LKTREGNVRVSRELPGHTGYLSCCRFLDDGQIITSSGDTTCALWDIETGQQTTTFTGHSGDVMSLSLSPDLKTFVSGACD 169
Cdd:COG2319    20 LLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAD 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937 170 ASSKLWDIRDGMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFDLRADQELL-LYSHDNiicGITSVAFSKSGRL 248
Cdd:COG2319   100 GTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRtLTGHSG---AVTSVAFSPDGKL 176

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1143076937 249 LLAGYDDFNCSVWDALKGGRSGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 304
Cdd:COG2319   177 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232
WD40 COG2319
WD40 repeat [General function prediction only];
10-179 1.17e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 1.17e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937  10 RTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 89
Cdd:COG2319   237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937  90 LKTRegnvRVSRELPGHTGYLSCCRFLDDGQ-IITSSGDTTCALWDIETGQQTTTFTGHSGDVMSLSLSPDLKTFVSGAC 168
Cdd:COG2319   317 LATG----KLLRTLTGHTGAVRSVAFSPDGKtLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392

                         170
                  ....*....|.
gi 1143076937 169 DASSKLWDIRD 179
Cdd:COG2319   393 DGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
114-304 2.29e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.53  E-value: 2.29e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937 114 RFLDDGQIITSSGDTTCALWDIETGQQTTTFTGHSGDVMSLSLSPDLKTFVSGACDASSKLWDIRDGMCRQSFTGHISDI 193
Cdd:COG2319     2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937 194 NAVSFFPSGYAFATGSDDATCRLFDLRADQEL-LLYSHDNiicGITSVAFSKSGRLLLAGYDDFNCSVWDALKGGRSGVL 272
Cdd:COG2319    82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLrTLTGHTG---AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1143076937 273 AGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 304
Cdd:COG2319   159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 182-304 4.07e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.69  E-value: 4.07e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937 182 CRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFDLRADQELL-LYSHDNiicGITSVAFSKSGRLLLAGYDDFNCSV 260
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRtLKGHTG---PVRDVAASADGTYLASGSSDKTIRL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1143076937 261 WDALKGGRSGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 304
Cdd:cd00200    78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-134 7.84e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.22  E-value: 7.84e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937   9 MRTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIY 88
Cdd:cd00200   167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1143076937  89 NLKTREgnvrVSRELPGHTGYLSCCRFLDDGQ-IITSSGDTTCALWD 134
Cdd:cd00200   247 DLRTGE----CVQTLSGHTNSVTSLAWSPDGKrLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 4-135 7.36e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.47  E-value: 7.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937   4 VGRIQMRTRrtLRGHLAKIYAMHWGY-DSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSwvMTCAYAPS--GNYVACGG 80
Cdd:PLN00181  562 VARSQLVTE--MKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN--ICCVQFPSesGRSLAFGS 637

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937  81 LDNICSIYNLKtregnvrvSRELP-----GHTGYLSCCRFLDDGQIITSSGDTTCALWDI 135
Cdd:PLN00181  638 ADHKVYYYDLR--------NPKLPlctmiGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDL 689
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 61-295 6.87e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.39  E-value: 6.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937  61 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKT-----REGNVRVSrELPGHTGYLSCC-RFLDDGQIITSSGDTTCALWD 134
Cdd:PLN00181  483 SNLVCAIGFDRDGEFFATAGVNKKIKIFECESiikdgRDIHYPVV-ELASRSKLSGICwNSYIKSQVASSNFEGVVQVWD 561

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937 135 IETGQQTTTFTGHSGDVMSLSLSP-DLKTFVSGACDASSKLWDIRDGMCRQSFTGHiSDINAVSfFPS--GYAFATGSDD 211
Cdd:PLN00181  562 VARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTK-ANICCVQ-FPSesGRSLAFGSAD 639

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076937 212 ATCRLFDLRADQELL--LYSHDNIicgITSVAFSKSGRLLLAGYDDfNCSVWDaLKGGRSGV-------LAGHDNRVSCL 282
Cdd:PLN00181  640 HKVYYYDLRNPKLPLctMIGHSKT---VSYVRFVDSSTLVSSSTDN-TLKLWD-LSMSISGInetplhsFMGHTNVKNFV 714

                         250
                  ....*....|...
gi 1143076937 283 GVTDDGMAVATGS 295
Cdd:PLN00181  715 GLSVSDGYIATGS 727
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 179-218 9.47e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 9.47e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1143076937  179 DGMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFD 218
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 13-47 3.40e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 3.40e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1143076937   13 RTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWD 47
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
180-218 5.27e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 5.27e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1143076937 180 GMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFD 218
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
13-47 5.27e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 5.27e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1143076937  13 RTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWD 47
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
270-304 3.22e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.22e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1143076937 270 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 304
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 271-304 5.83e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 5.83e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1143076937  271 VLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 304
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 275-303 4.09e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.51  E-value: 4.09e-03
                          10        20
                  ....*....|....*....|....*....
gi 1143076937 275 HDNRVSCLGVTDDGMAVATGSWDSFLRIW 303
Cdd:pfam20426 123 HKDVVSCVAVTSDGSILATGSYDTTVMVW 151
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 98-134 5.09e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 5.09e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1143076937   98 RVSRELPGHTGYLSCCRFLDDGQ-IITSSGDTTCALWD 134
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKyLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
101-134 7.38e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 7.38e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1143076937 101 RELPGHTGYLSCCRFLDDGQ-IITSSGDTTCALWD 134
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKlLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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