NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1143474944|ref|NP_001335569|]
View 

EF-hand domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
PPP2R3A_B-like cd21504
serine/threonine protein phosphatase 2A regulatory subunit B" alpha and beta subunits, and ...
983-1259 1.19e-145

serine/threonine protein phosphatase 2A regulatory subunit B" alpha and beta subunits, and similar proteins; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. These B-family regulatory subunits play various roles including regulation of cytoskeletal assembly, neuronal differentiation, mitogen-activated protein kinase signaling, and apoptosis. This subfamily includes protein phosphatase 2A regulatory subunit B'' subunits alpha and beta, encoded by PPP2R3A and PPP2R3B. It also includes subunit delta encoded by PPP2R3D in mouse. They contain two-domain elongated structures with two calcium EF-hands which mediate Ca2+-dependent changes in phosphatase activity.


:

Pssm-ID: 410337  Cd Length: 274  Bit Score: 442.37  E-value: 1.19e-145
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  983 WKAMTSVAHDEAARFVYTLTMGSRSYLQPEDFYEMLMDVIHTHPGLAFYRDATEFHDKYCQVVMTRIFWNDAHSWSGRLT 1062
Cdd:cd21504      1 WKKILAGCHDDASRFFRILKKPDRNYLVPEDFKPFLQDLLDTHPGLEFLQDTPEFQERYAETVIYRIFYSVNRSWSGRIT 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944 1063 TERLRKGGVLQAIRNLQFDDDINKSLRYFSYEHFYVVYCKFWEIDSDHDLKISSTDLAQHAGGALVPMVVDRIFSGAVCT 1142
Cdd:cd21504     81 LRELRRSNLLQALLLLDEEEDINKVLRYFSYEHFYVIYCKFWELDTDHDLLIDKDDLLRYGDHALSPRIVDRIFSGAVRR 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944 1143 NPNrgQPVEDIGLAEFTQFLLAEEDKTHPTSIEYWFRILDLDGDGLVTLYDMELFHTQVQRKLAAEGIDSMGFADVACQL 1222
Cdd:cd21504    161 FKS--GKEGKMSYEDFVWFILSEEDKTSPTSIEYWFRCMDLDGDGVLSMYEMEYFYEEQLQRMECLGIEPVPFEDILCQM 238
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1143474944 1223 IDMLNvPGGVSAFRLSDLKKSSLRGRFINTFVNWRKF 1259
Cdd:cd21504    239 LDMIK-PENEGKITLRDLKRCKLAGNFFNTLFNLNKF 274
PHA03247 super family cl33720
large tegument protein UL36; Provisional
473-937 4.02e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 4.02e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  473 SGQGVAARKaelmREPSV-EYTEKPRTPLNPAFPSNSFLIPSFNELDNAVNE---LSRTVRGNTFGGTTFGSVSPAPVVH 548
Cdd:PHA03247  2578 SEPAVTSRA----RRPDApPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDpppPSPSPAANEPDPHPPPTVPPPERPR 2653
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  549 ND------SLNRRVGGCGRFPtgeHAFSPP--PIEVSKSPALSLHRKLHSPSPtdevsesssvyqiPTGLPHPKPKHNVK 620
Cdd:PHA03247  2654 DDpapgrvSRPRRARRLGRAA---QASSPPqrPRRRAARPTVGSLTSLADPPP-------------PPPTPEPAPHALVS 2717
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  621 eqlhlAGIHTPGYQISRTMYRNGPNFPVPSTGSVASRITEFEKRPGTPvvQLSTTtvkynehvPVAATAKAVPQTNgnmS 700
Cdd:PHA03247  2718 -----ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARP--PTTAG--------PPAPAPPAAPAAG---P 2779
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  701 PRSAvfrakPVIHVDMGSTYQHSSPTPPirhiqvhsvqnqnhqplqnhqnhqsylgkeqhnhyrpqyqqqpikqhDIATH 780
Cdd:PHA03247  2780 PRRL-----TRPAVASLSESRESLPSPW-----------------------------------------------DPADP 2807
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  781 SIfdfksnNVSAASATQIQADVTPTKSAHPAELNVVSPPKRTASVPASrLNLNGTLDSNGNYGRKSASQSdlnysAELSV 860
Cdd:PHA03247  2808 PA------AVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPS-LPLGGSVAPGGDVRRRPPSRS-----PAAKP 2875
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  861 AAPTR--------HAIPELDLTFDSYNDEQYRPTPKPTQVISRPLPPKPQAPKE-PIYYPQGKPVPQLQNDTALRRVCEV 931
Cdd:PHA03247  2876 AAPARppvrrlarPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPqPPPPPPPRPQPPLAPTTDPAGAGEP 2955

                   ....*.
gi 1143474944  932 FRSVPN 937
Cdd:PHA03247  2956 SGAVPQ 2961
 
Name Accession Description Interval E-value
PPP2R3A_B-like cd21504
serine/threonine protein phosphatase 2A regulatory subunit B" alpha and beta subunits, and ...
983-1259 1.19e-145

serine/threonine protein phosphatase 2A regulatory subunit B" alpha and beta subunits, and similar proteins; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. These B-family regulatory subunits play various roles including regulation of cytoskeletal assembly, neuronal differentiation, mitogen-activated protein kinase signaling, and apoptosis. This subfamily includes protein phosphatase 2A regulatory subunit B'' subunits alpha and beta, encoded by PPP2R3A and PPP2R3B. It also includes subunit delta encoded by PPP2R3D in mouse. They contain two-domain elongated structures with two calcium EF-hands which mediate Ca2+-dependent changes in phosphatase activity.


Pssm-ID: 410337  Cd Length: 274  Bit Score: 442.37  E-value: 1.19e-145
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  983 WKAMTSVAHDEAARFVYTLTMGSRSYLQPEDFYEMLMDVIHTHPGLAFYRDATEFHDKYCQVVMTRIFWNDAHSWSGRLT 1062
Cdd:cd21504      1 WKKILAGCHDDASRFFRILKKPDRNYLVPEDFKPFLQDLLDTHPGLEFLQDTPEFQERYAETVIYRIFYSVNRSWSGRIT 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944 1063 TERLRKGGVLQAIRNLQFDDDINKSLRYFSYEHFYVVYCKFWEIDSDHDLKISSTDLAQHAGGALVPMVVDRIFSGAVCT 1142
Cdd:cd21504     81 LRELRRSNLLQALLLLDEEEDINKVLRYFSYEHFYVIYCKFWELDTDHDLLIDKDDLLRYGDHALSPRIVDRIFSGAVRR 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944 1143 NPNrgQPVEDIGLAEFTQFLLAEEDKTHPTSIEYWFRILDLDGDGLVTLYDMELFHTQVQRKLAAEGIDSMGFADVACQL 1222
Cdd:cd21504    161 FKS--GKEGKMSYEDFVWFILSEEDKTSPTSIEYWFRCMDLDGDGVLSMYEMEYFYEEQLQRMECLGIEPVPFEDILCQM 238
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1143474944 1223 IDMLNvPGGVSAFRLSDLKKSSLRGRFINTFVNWRKF 1259
Cdd:cd21504    239 LDMIK-PENEGKITLRDLKRCKLAGNFFNTLFNLNKF 274
EF-hand_13 pfam17958
EF-hand domain; This entry represents an EF-hand domain found in one of the regulatory B ...
992-1079 4.13e-34

EF-hand domain; This entry represents an EF-hand domain found in one of the regulatory B subunits of PP2A.


Pssm-ID: 465586 [Multi-domain]  Cd Length: 90  Bit Score: 125.94  E-value: 4.13e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  992 DEAARFVYTLTMGSRSYLQPEDFYEMLMDVIHTHPGLAFYRDATEFHDKYCQVVMTRIFWNDAHSWSGRLTTERLRKGGV 1071
Cdd:pfam17958    1 DEAARFFRLLKGPGKNYLSREDFYPFVQDVVDTHPGLEFLREAEEFQDKYIQTVIARIFYVVNRSWSGKITLLELRKSDL 80

                   ....*...
gi 1143474944 1072 LQAIRNLQ 1079
Cdd:pfam17958   81 LKAVRQLD 88
PHA03247 PHA03247
large tegument protein UL36; Provisional
473-937 4.02e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 4.02e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  473 SGQGVAARKaelmREPSV-EYTEKPRTPLNPAFPSNSFLIPSFNELDNAVNE---LSRTVRGNTFGGTTFGSVSPAPVVH 548
Cdd:PHA03247  2578 SEPAVTSRA----RRPDApPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDpppPSPSPAANEPDPHPPPTVPPPERPR 2653
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  549 ND------SLNRRVGGCGRFPtgeHAFSPP--PIEVSKSPALSLHRKLHSPSPtdevsesssvyqiPTGLPHPKPKHNVK 620
Cdd:PHA03247  2654 DDpapgrvSRPRRARRLGRAA---QASSPPqrPRRRAARPTVGSLTSLADPPP-------------PPPTPEPAPHALVS 2717
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  621 eqlhlAGIHTPGYQISRTMYRNGPNFPVPSTGSVASRITEFEKRPGTPvvQLSTTtvkynehvPVAATAKAVPQTNgnmS 700
Cdd:PHA03247  2718 -----ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARP--PTTAG--------PPAPAPPAAPAAG---P 2779
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  701 PRSAvfrakPVIHVDMGSTYQHSSPTPPirhiqvhsvqnqnhqplqnhqnhqsylgkeqhnhyrpqyqqqpikqhDIATH 780
Cdd:PHA03247  2780 PRRL-----TRPAVASLSESRESLPSPW-----------------------------------------------DPADP 2807
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  781 SIfdfksnNVSAASATQIQADVTPTKSAHPAELNVVSPPKRTASVPASrLNLNGTLDSNGNYGRKSASQSdlnysAELSV 860
Cdd:PHA03247  2808 PA------AVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPS-LPLGGSVAPGGDVRRRPPSRS-----PAAKP 2875
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  861 AAPTR--------HAIPELDLTFDSYNDEQYRPTPKPTQVISRPLPPKPQAPKE-PIYYPQGKPVPQLQNDTALRRVCEV 931
Cdd:PHA03247  2876 AAPARppvrrlarPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPqPPPPPPPRPQPPLAPTTDPAGAGEP 2955

                   ....*.
gi 1143474944  932 FRSVPN 937
Cdd:PHA03247  2956 SGAVPQ 2961
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
1103-1213 4.24e-05

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 44.78  E-value: 4.24e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944 1103 FWEIDSDHDLKISSTDLAqhaggALVPMVVDRIFSGAVCTNPNRgqpvedIGLAEFTQFLLAEEDKTHPTSIEYWFRILD 1182
Cdd:COG5126     11 FDLLDADGDGVLERDDFE-----ALFRRLWATLFSEADTDGDGR------ISREEFVAGMESLFEATVEPFARAAFDLLD 79
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1143474944 1183 LDGDGLVTLYDMELFHTQ--VQRKLAAEGIDSM 1213
Cdd:COG5126     80 TDGDGKISADEFRRLLTAlgVSEEEADELFARL 112
 
Name Accession Description Interval E-value
PPP2R3A_B-like cd21504
serine/threonine protein phosphatase 2A regulatory subunit B" alpha and beta subunits, and ...
983-1259 1.19e-145

serine/threonine protein phosphatase 2A regulatory subunit B" alpha and beta subunits, and similar proteins; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. These B-family regulatory subunits play various roles including regulation of cytoskeletal assembly, neuronal differentiation, mitogen-activated protein kinase signaling, and apoptosis. This subfamily includes protein phosphatase 2A regulatory subunit B'' subunits alpha and beta, encoded by PPP2R3A and PPP2R3B. It also includes subunit delta encoded by PPP2R3D in mouse. They contain two-domain elongated structures with two calcium EF-hands which mediate Ca2+-dependent changes in phosphatase activity.


Pssm-ID: 410337  Cd Length: 274  Bit Score: 442.37  E-value: 1.19e-145
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  983 WKAMTSVAHDEAARFVYTLTMGSRSYLQPEDFYEMLMDVIHTHPGLAFYRDATEFHDKYCQVVMTRIFWNDAHSWSGRLT 1062
Cdd:cd21504      1 WKKILAGCHDDASRFFRILKKPDRNYLVPEDFKPFLQDLLDTHPGLEFLQDTPEFQERYAETVIYRIFYSVNRSWSGRIT 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944 1063 TERLRKGGVLQAIRNLQFDDDINKSLRYFSYEHFYVVYCKFWEIDSDHDLKISSTDLAQHAGGALVPMVVDRIFSGAVCT 1142
Cdd:cd21504     81 LRELRRSNLLQALLLLDEEEDINKVLRYFSYEHFYVIYCKFWELDTDHDLLIDKDDLLRYGDHALSPRIVDRIFSGAVRR 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944 1143 NPNrgQPVEDIGLAEFTQFLLAEEDKTHPTSIEYWFRILDLDGDGLVTLYDMELFHTQVQRKLAAEGIDSMGFADVACQL 1222
Cdd:cd21504    161 FKS--GKEGKMSYEDFVWFILSEEDKTSPTSIEYWFRCMDLDGDGVLSMYEMEYFYEEQLQRMECLGIEPVPFEDILCQM 238
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1143474944 1223 IDMLNvPGGVSAFRLSDLKKSSLRGRFINTFVNWRKF 1259
Cdd:cd21504    239 LDMIK-PENEGKITLRDLKRCKLAGNFFNTLFNLNKF 274
PPP2R3B cd21507
serine/threonine protein phosphatase 2A regulatory subunit B" subunit beta; Heterotrimeric ...
909-1263 1.59e-105

serine/threonine protein phosphatase 2A regulatory subunit B" subunit beta; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This group contains protein phosphatase subunit PR70 (also known as protein phosphatase 2 regulatory subunit B'' subunit beta, PR48, NYREN8, PPP2R3L, or PPP2R3LY) that is encoded by the PPP2R3B gene. This substrate-recognizing subunit of PP2A has a two-domain elongated structure with two calcium EF-hands, each displaying different affinities to Ca2+. PPP2R3B/PR70 is a gonosomal melanoma tumor suppressor gene; PR70 decreased melanoma growth by negatively interfering with DNA replication and cell cycle progression through its role in stabilizing the cell division cycle 6 (CDC6)-chromatin licensing and DNA replication factor 1 (CDT1) interaction, which delays the firing of origins of DNA replication.


Pssm-ID: 410340  Cd Length: 355  Bit Score: 338.47  E-value: 1.59e-105
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  909 YYPQGKPVPQLQNDTALRRVCEVFRSVPNQKCTLENMPAVCEAAGLPMYWKMPVFLAITNDEDRLATQVDFTSWWKAMTS 988
Cdd:cd21507      1 YFPRGCPKDSVNVDAVIAKIENTFSQFPNERATLDDMGKVAKACDCPLYWKGPLFYAAGGERTGSVSVHKFVAMWRKILQ 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  989 VAHDEAARFVYTLTMGSRSYLQPEDFYEMLMDVIHTHPGLAFYRDATEFHDKYCQVVMTRIFWNDAHSWSGRLTTERLRK 1068
Cdd:cd21507     81 NCHDDAAKFVHLLMKPGCNYLVQEDFIPFLQDVVNTHPGLSFLKEASEFHSRYITTVIQRIFYTVNRSWSGRITCTELRR 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944 1069 GGVLQAIRNLQFDDDINKSLRYFSYEHFYVVYCKFWEIDSDHDLKISSTDLAQHAGGALVPMVVDRIFSGAVcTNPNRGQ 1148
Cdd:cd21507    161 SSFLQNVALLEEEADINQLTEFFSYEHFYVIYCKFWELDTDHDLYIDQKDLARHNDHAISNRMIERIFSGAV-TRGRKAQ 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944 1149 PVEDIGLAEFTQFLLAEEDKTHPTSIEYWFRILDLDGDGLVTLYDMELFHTQVQRKLAAEGIDSMGFADVACQLIDMLNv 1228
Cdd:cd21507    240 KEGKISYADFVWFLISEEDKKTPTSIEYWFRCMDLDGDGALSMYELEYFYEEQCQKLDNMAIEPLPFEDCLCQMLDLVK- 318
                          330       340       350
                   ....*....|....*....|....*....|....*
gi 1143474944 1229 PGGVSAFRLSDLKKSSLRGRFINTFVNWRKFFAQE 1263
Cdd:cd21507    319 PRTEGKITLHDLKRCKLANVFFDTFFNIEKYLDHE 353
PPP2R3A cd21506
serine/threonine protein phosphatase 2A regulatory subunit B" subunit alpha; Heterotrimeric ...
983-1263 1.92e-89

serine/threonine protein phosphatase 2A regulatory subunit B" subunit alpha; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This group contains protein phosphatase subunit PR130 (also known as protein phosphatase 2A regulatory subunit B'' subunit alpha, PR72, or PPP2R3) that is encoded by the PPP2R3A gene. PR130 and PR72 subunits are derived from the same gene through differential splicing; they harbor specific N-terminal domains of different lengths that are encoded by alternatively spliced exons and have identical C-termini. The common C-terminus contains a two-domain elongated structure with two calcium EF-hands which mediate Ca2+-dependent changes in phosphatase activity. The PR130 subunit has been shown to interact with the LIM domain of lipoma-preferred partner (LPP) through a conserved Zn2+-finger-like motif in the N-terminus of PR130.


Pssm-ID: 410339  Cd Length: 284  Bit Score: 291.45  E-value: 1.92e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  983 WKAMTSVAHDEAARFVYTLTMGSRSYLQPEDFYEMLMDVIHTHPGLAFYRDATEFHDKYCQVVMTRIFWNDAHSWSGRLT 1062
Cdd:cd21506      1 WRKLLNNCHDDASKFVYLLAKPNCSYLEQEDFIPLLQDIVDTHPGLTFLKDAPEFHSRYITTVIQRIFYTVNRSWSGKIT 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944 1063 TERLRKGGVLQAIRNLQFDDDINKSLRYFSYEHFYVVYCKFWEIDSDHDLKISSTDLAQHAGGALVPMVVDRIFSGAVct 1142
Cdd:cd21506     81 LTELRKSNFLQTLALLEEEDDINQITDYFSYEHFYVIYCKFWELDTDHDLYIDQKDLARYNDQASSSRIIERIFSGAV-- 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944 1143 npNRGQPVEDIG---LAEFTQFLLAEEDKTHPTSIEYWFRILDLDGDGLVTLYDMELFHTQVQRKLAAEGIDSMGFADVA 1219
Cdd:cd21506    159 --TRGNSVQKEGrmsYADFVWFLISEEDKRNPTSIEYWFRCMDLDGDGVLSMYELEYFYEEQCERMEAMGIEPLPFHDLL 236
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1143474944 1220 CQLIDMLNvPGGVSAFRLSDLKKSSLRGRFINTFVNWRKFFAQE 1263
Cdd:cd21506    237 CQMLDLVK-PEVDGKITLRDLKRCRMAHIFYDTFFNLEKYLDHE 279
PPP2R3 cd21339
serine/threonine protein phosphatase 2A regulatory subunit B"; Heterotrimeric serine/threonine ...
993-1253 2.98e-73

serine/threonine protein phosphatase 2A regulatory subunit B"; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This family includes PP2A regulatory B'' subunits alpha, beta and gamma, encoded by PPP2R3A, PPP2R3B and PPP2R3C, respectively. It also includes subunit delta encoded by PPP2R3D in mouse. These B-family regulatory subunits play various roles including regulation of cytoskeletal assembly, neuronal differentiation, mitogen-activated protein kinase signaling, and apoptosis. Subunits alpha and beta contain two-domain elongated structure with two calcium EF-hands which mediate Ca2+-dependent changes in phosphatase activity.


Pssm-ID: 410336  Cd Length: 259  Bit Score: 244.80  E-value: 2.98e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  993 EAARFVYTLTMGSRSYLQPEDFYEMLMDVIHTHPGLAFYRDATEFHDKYCQVVMTRIFWNDAHSWSGRLTTERLRKGGVL 1072
Cdd:cd21339      1 DATKFGLLLYDPGCGYLRQEDFEPYLQDVVPTHPGLDFLKKAPEFHSRYITTVIQRIFYFVNRSWSGKITIQEIRASSFL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944 1073 QAIRNLQFDDDINKSLRYFSYEHFYVVYCKFWEIDSDHDLKISSTDLAQHAGGALVPMVVDRIFSGAVcTNPNRGQPVED 1152
Cdd:cd21339     81 QDLALLEEEEDINQETNWFSYEHFYVIYCKFWELDTDHDLMISKEDLSRYNDAAMSNVFIDRIFSGAV-TRGKTIQKEGE 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944 1153 IGLAEFTQFLLAEEDKTHPTSIEYWFRILDLDGDGLVTLYDMELFHTQVQRKLAAEGIDSMGFADVACQLIDMLN--VPG 1230
Cdd:cd21339    160 MSYADFVWFLISEEDKKEPTSIEYWFRCLDIDGDGYLSVFELEYFYEEQCERMKIHGIEPLPFQDVLCQILDLVKpkDPG 239
                          250       260
                   ....*....|....*....|...
gi 1143474944 1231 GVSafrLSDLKKSSLRGRFINTF 1253
Cdd:cd21339    240 KIT---LQDLKRCNIALNFFDTF 259
EF-hand_13 pfam17958
EF-hand domain; This entry represents an EF-hand domain found in one of the regulatory B ...
992-1079 4.13e-34

EF-hand domain; This entry represents an EF-hand domain found in one of the regulatory B subunits of PP2A.


Pssm-ID: 465586 [Multi-domain]  Cd Length: 90  Bit Score: 125.94  E-value: 4.13e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  992 DEAARFVYTLTMGSRSYLQPEDFYEMLMDVIHTHPGLAFYRDATEFHDKYCQVVMTRIFWNDAHSWSGRLTTERLRKGGV 1071
Cdd:pfam17958    1 DEAARFFRLLKGPGKNYLSREDFYPFVQDVVDTHPGLEFLREAEEFQDKYIQTVIARIFYVVNRSWSGKITLLELRKSDL 80

                   ....*...
gi 1143474944 1072 LQAIRNLQ 1079
Cdd:pfam17958   81 LKAVRQLD 88
PPP2R3C cd21505
serine/threonine protein phosphatase 2A regulatory subunit B" subunit gamma; Heterotrimeric ...
1008-1266 2.28e-18

serine/threonine protein phosphatase 2A regulatory subunit B" subunit gamma; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This subfamily includes protein phosphatase subunit G5PR (also known as serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma, G4-1, G5pr, GDRM, SPGF36, or C14orf10) that is encoded by the PPP2R3C gene. It is involved in the control of the dynamic organization of the cortical cytoskeleton and plays an important role in the organization of interphase microtubule arrays in part through the regulation of nucleation geometry. G5PR is involved in the ontogeny of multiple organs, especially critical for testis development and spermatogenesis. PPP2R3C gene variants cause syndromic 46,XY gonadal dysgenesis and impaired spermatogenesis in humans, and thus is emerging as a potential therapeutic target for male infertility.


Pssm-ID: 410338 [Multi-domain]  Cd Length: 382  Bit Score: 88.78  E-value: 2.28e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944 1008 YLQPEDFYEMLMDVIHTHPGLAFYRDatEFHDKYCQVVMTRIFWNDAHSWSGRLTTERLRKGGVLQAIRNLQfDDDINKS 1087
Cdd:cd21505    132 FLTESDLENYILELIPTLPQLSGLEE--SFYSFYVCTAVRKFFFFLDPLRRGKIRIKDILASPFLDELLELR-DEELSEE 208
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944 1088 LRY---FSYEHFYVVYCKFWEIDSDHDLKISSTDLAQHAGGALVPMVVDRIFSgaVCTNPNRgqpveDIGLAEFTQFLLA 1164
Cdd:cd21505    209 LQEsnwFSAPSALRVYGQYLNLDKDHNGMLSKQELSRYGKGTLTSVFIDRVFQ--ECLTYNG-----EMDYKTFLDFVLA 281
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944 1165 EEDKTHPTSIEYWFRILDLDGDGLVTLYDMELFHTQVQRKLAAEGIDSMGFADVACQLIDMLNvPGGVSAFRLSDLKKSS 1244
Cdd:cd21505    282 MENRKEPQALQYFFRILDLKGQGYLTPFTLNYFFRAIQEKMKEHGQEPVSFEDVKDEIFDMVK-PKDPLKITLQDLINSG 360
                          250       260
                   ....*....|....*....|..
gi 1143474944 1245 LRGRFINTFVNWRKFFAQETNE 1266
Cdd:cd21505    361 QGDTVVSILIDLNGFWAYENRE 382
EF-hand_7 pfam13499
EF-hand domain pair;
1096-1195 2.41e-05

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 43.40  E-value: 2.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944 1096 FYVVYCKFWEIDSDHDLKISstdlaqhaggalvpmvvdrifsgavctnpnrgqpvedigLAEFTQFL--LAEEDKTHPTS 1173
Cdd:pfam13499    1 EEKLKEAFKLLDSDGDGYLD---------------------------------------VEELKKLLrkLEEGEPLSDEE 41
                           90       100
                   ....*....|....*....|..
gi 1143474944 1174 IEYWFRILDLDGDGLVTLYDME 1195
Cdd:pfam13499   42 VEELFKEFDLDKDGRISFEEFL 63
PHA03247 PHA03247
large tegument protein UL36; Provisional
473-937 4.02e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 4.02e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  473 SGQGVAARKaelmREPSV-EYTEKPRTPLNPAFPSNSFLIPSFNELDNAVNE---LSRTVRGNTFGGTTFGSVSPAPVVH 548
Cdd:PHA03247  2578 SEPAVTSRA----RRPDApPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDpppPSPSPAANEPDPHPPPTVPPPERPR 2653
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  549 ND------SLNRRVGGCGRFPtgeHAFSPP--PIEVSKSPALSLHRKLHSPSPtdevsesssvyqiPTGLPHPKPKHNVK 620
Cdd:PHA03247  2654 DDpapgrvSRPRRARRLGRAA---QASSPPqrPRRRAARPTVGSLTSLADPPP-------------PPPTPEPAPHALVS 2717
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  621 eqlhlAGIHTPGYQISRTMYRNGPNFPVPSTGSVASRITEFEKRPGTPvvQLSTTtvkynehvPVAATAKAVPQTNgnmS 700
Cdd:PHA03247  2718 -----ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARP--PTTAG--------PPAPAPPAAPAAG---P 2779
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  701 PRSAvfrakPVIHVDMGSTYQHSSPTPPirhiqvhsvqnqnhqplqnhqnhqsylgkeqhnhyrpqyqqqpikqhDIATH 780
Cdd:PHA03247  2780 PRRL-----TRPAVASLSESRESLPSPW-----------------------------------------------DPADP 2807
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  781 SIfdfksnNVSAASATQIQADVTPTKSAHPAELNVVSPPKRTASVPASrLNLNGTLDSNGNYGRKSASQSdlnysAELSV 860
Cdd:PHA03247  2808 PA------AVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPS-LPLGGSVAPGGDVRRRPPSRS-----PAAKP 2875
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  861 AAPTR--------HAIPELDLTFDSYNDEQYRPTPKPTQVISRPLPPKPQAPKE-PIYYPQGKPVPQLQNDTALRRVCEV 931
Cdd:PHA03247  2876 AAPARppvrrlarPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPqPPPPPPPRPQPPLAPTTDPAGAGEP 2955

                   ....*.
gi 1143474944  932 FRSVPN 937
Cdd:PHA03247  2956 SGAVPQ 2961
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
1103-1213 4.24e-05

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 44.78  E-value: 4.24e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944 1103 FWEIDSDHDLKISSTDLAqhaggALVPMVVDRIFSGAVCTNPNRgqpvedIGLAEFTQFLLAEEDKTHPTSIEYWFRILD 1182
Cdd:COG5126     11 FDLLDADGDGVLERDDFE-----ALFRRLWATLFSEADTDGDGR------ISREEFVAGMESLFEATVEPFARAAFDLLD 79
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1143474944 1183 LDGDGLVTLYDMELFHTQ--VQRKLAAEGIDSM 1213
Cdd:COG5126     80 TDGDGKISADEFRRLLTAlgVSEEEADELFARL 112
PHA03378 PHA03378
EBNA-3B; Provisional
707-939 6.29e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.21  E-value: 6.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  707 RAKPVIHvdmGStyQHSSPTPPIRHIQVHSVQNQNHQPLQNHQNHQSYLGKEQHN-------HYRPQYQQQPIKQHDIAT 779
Cdd:PHA03378   595 TPWPVPH---PS--QTPEPPTTQSHIPETSAPRQWPMPLRPIPMRPLRMQPITFNvlvfptpHQPPQVEITPYKPTWTQI 669
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  780 HSIfdfKSNNVSAASATQIQADVTPTKSAHPAELNVVSPPKRTASVPASRlnlngtldSNGNYGRKSASQSDLNySAELS 859
Cdd:PHA03378   670 GHI---PYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQR--------PAAATGRARPPAAAPG-RARPP 737
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143474944  860 VAAPTRHAIPELDLTFDSYNDEQYRPTPKPTQVISRPLP-PKPQAPKEPIYYPQGKPVPQLQNDTALRRVCEVFRSVPNQ 938
Cdd:PHA03378   738 AAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPqPPPQAPPAPQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQ 817

                   .
gi 1143474944  939 K 939
Cdd:PHA03378   818 Q 818
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH