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Conserved domains on  [gi|1174098829|ref|NP_001337071|]
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protein arginine N-methyltransferase 9 isoform 2 [Homo sapiens]

Protein Classification

SAM-dependent methyltransferase( domain architecture ID 1905023)

SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4076 super family cl44002
Predicted RNA methylase [General function prediction only];
35-206 2.09e-38

Predicted RNA methylase [General function prediction only];


The actual alignment was detected with superfamily member COG4076:

Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 142.48  E-value: 2.09e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098829  35 LVERWHFIMLNDTKRNTIYNAAIQKAVCLGSKsVLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACDVVAANKMEA 114
Cdd:COG4076     7 FVPRWHHPMLNDVERNDAFKAAIERVVKPGDV-VLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098829 115 GIKLLHTKSLDIEipkhIPERVSLVVTETVDAGLFGEGIVESLIHAWEHLLlqpktkgesancEKYGKVIPASAVIFGMA 194
Cdd:COG4076    86 RITVINADATDLD----LPEKADVIISEMLDTALLDEGQVPILNHARKRLL------------KPGGRIIPERITNAAQP 149

                         170
                  ....*....|..
gi 1174098829 195 VECAEIRRHHRV 206
Cdd:COG4076   150 VESPVDAEGFED 161
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
35-206 2.09e-38

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 142.48  E-value: 2.09e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098829  35 LVERWHFIMLNDTKRNTIYNAAIQKAVCLGSKsVLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACDVVAANKMEA 114
Cdd:COG4076     7 FVPRWHHPMLNDVERNDAFKAAIERVVKPGDV-VLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098829 115 GIKLLHTKSLDIEipkhIPERVSLVVTETVDAGLFGEGIVESLIHAWEHLLlqpktkgesancEKYGKVIPASAVIFGMA 194
Cdd:COG4076    86 RITVINADATDLD----LPEKADVIISEMLDTALLDEGQVPILNHARKRLL------------KPGGRIIPERITNAAQP 149

                         170
                  ....*....|..
gi 1174098829 195 VECAEIRRHHRV 206
Cdd:COG4076   150 VESPVDAEGFED 161
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 68-140 1.93e-07

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 49.74  E-value: 1.93e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1174098829  68 VLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACDVVAANKMEaGIKLLHTKSLdiEIPKHIPERVSLVV 140
Cdd:cd02440     2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLAD-NVEVLKGDAE--ELPPEADESFDVII 71
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 68-103 6.46e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 45.25  E-value: 6.46e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1174098829  68 VLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELA 103
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERA 36
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
56-93 1.08e-05

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 47.45  E-value: 1.08e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1174098829  56 AIQKAVcLGSKSVLDIGAGTGILSMFAKKAGAHSVYAC 93
Cdd:PRK00517  112 ALEKLV-LPGKTVLDVGCGSGILAIAAAKLGAKKVLAV 148
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
35-206 2.09e-38

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 142.48  E-value: 2.09e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098829  35 LVERWHFIMLNDTKRNTIYNAAIQKAVCLGSKsVLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACDVVAANKMEA 114
Cdd:COG4076     7 FVPRWHHPMLNDVERNDAFKAAIERVVKPGDV-VLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098829 115 GIKLLHTKSLDIEipkhIPERVSLVVTETVDAGLFGEGIVESLIHAWEHLLlqpktkgesancEKYGKVIPASAVIFGMA 194
Cdd:COG4076    86 RITVINADATDLD----LPEKADVIISEMLDTALLDEGQVPILNHARKRLL------------KPGGRIIPERITNAAQP 149

                         170
                  ....*....|..
gi 1174098829 195 VECAEIRRHHRV 206
Cdd:COG4076   150 VESPVDAEGFED 161
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 66-141 2.26e-10

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 61.31  E-value: 2.26e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1174098829  66 KSVLDIGAGTGILS-MFAKKAGAHSVYACELSKTMYELACDVVAANKMEAGIKLLHTkslDI-EIPKHI-PERVSLVVT 141
Cdd:COG4123    39 GRVLDLGTGTGVIAlMLAQRSPGARITGVEIQPEAAELARRNVALNGLEDRITVIHG---DLkEFAAELpPGSFDLVVS 114
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 68-140 1.93e-07

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 49.74  E-value: 1.93e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1174098829  68 VLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACDVVAANKMEaGIKLLHTKSLdiEIPKHIPERVSLVV 140
Cdd:cd02440     2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLAD-NVEVLKGDAE--ELPPEADESFDVII 71
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
56-120 2.58e-07

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 52.87  E-value: 2.58e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1174098829  56 AIQKAVCLGsKSVLDIGAGTGILSMFAKKAGAHSVYACELSktmyELACDV----VAANKMEAGIKLLH 120
Cdd:COG2264   141 ALEKLLKPG-KTVLDVGCGSGILAIAAAKLGAKRVLAVDID----PVAVEAarenAELNGVEDRIEVVL 204
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 45-140 2.35e-06

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 47.32  E-value: 2.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098829  45 NDTKRNTIYNAAIQ---KAVCLGSKSVLDIGAGTGILSMFAKKAGAHsVYACELSKTMYELAcdvvAANKMEAGIKLLHT 121
Cdd:COG2227     2 SDPDARDFWDRRLAallARLLPAGGRVLDVGCGTGRLALALARRGAD-VTGVDISPEALEIA----RERAAELNVDFVQG 76

                          90
                  ....*....|....*....
gi 1174098829 122 KSLDIEIPkhiPERVSLVV 140
Cdd:COG2227    77 DLEDLPLE---DGSFDLVI 92
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 68-103 6.46e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 45.25  E-value: 6.46e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1174098829  68 VLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELA 103
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERA 36
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
56-93 1.08e-05

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 47.45  E-value: 1.08e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1174098829  56 AIQKAVcLGSKSVLDIGAGTGILSMFAKKAGAHSVYAC 93
Cdd:PRK00517  112 ALEKLV-LPGKTVLDVGCGSGILAIAAAKLGAKKVLAV 148
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 53-109 3.03e-05

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 44.60  E-value: 3.03e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1174098829  53 YNAAIQKAVCLGSKSVLDIGAGTGILSMFAKKAGAHsVYACELSKTMYELACDVVAA 109
Cdd:COG2226    11 REALLAALGLRPGARVLDLGCGTGRLALALAERGAR-VTGVDISPEMLELARERAAE 66
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
66-103 1.46e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 43.35  E-value: 1.46e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1174098829  66 KSVLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELA 103
Cdd:COG2263    47 KTVLDLGCGTGMLAIGAALLGAKKVVGVDIDPEALEIA 84
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 66-110 3.27e-04

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 42.56  E-value: 3.27e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1174098829  66 KSVLDIGAGTGILSMFAKKAGAHSVYACELSktmyELACDVVAAN 110
Cdd:COG3897    72 KRVLELGCGLGLVGIAAAKAGAADVTATDYD----PEALAALRLN 112
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 63-118 6.93e-04

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 42.25  E-value: 6.93e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1174098829  63 LGSKSVLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACDVVAANKMEAGIKL 118
Cdd:pfam06325 160 KPGESVLDVGCGSGILAIAALKLGAKKVVGVDIDPVAVRAAKENAELNGVEARLEV 215
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
52-140 7.19e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 41.14  E-value: 7.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098829  52 IYNAAIQKAVCLGSKSVLDIGAGTGILSMFAKKAGAHsVYACELSKTMYELacdvvaANKMEAGIKLLHTkslDIEIPKH 131
Cdd:COG4976    34 LAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYR-LTGVDLSEEMLAK------AREKGVYDRLLVA---DLADLAE 103


                  ....*....
gi 1174098829 132 IPERVSLVV 140
Cdd:COG4976   104 PDGRFDLIV 112
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 68-120 1.25e-03

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 39.91  E-value: 1.25e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1174098829  68 VLDIGAGTGILSMF-AKKAGAHsVYACELSKTMYELACDVVAANKMEAGIKLLH 120
Cdd:COG2230    55 VLDIGCGWGGLALYlARRYGVR-VTGVTLSPEQLEYARERAAEAGLADRVEVRL 107
PRK14968 PRK14968
putative methyltransferase; Provisional
 66-128 5.14e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 38.73  E-value: 5.14e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1174098829  66 KSVLDIGAGTGILSMFAKKAGaHSVYACELSktmyELACDVVAANkmeagIKLLHTKSLDIEI 128
Cdd:PRK14968   25 DRVLEVGTGSGIVAIVAAKNG-KKVVGVDIN----PYAVECAKCN-----AKLNNIRNNGVEV 77
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 69-103 7.93e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 36.49  E-value: 7.93e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1174098829  69 LDIGAGTGILSMFAKKAGAHsVYACELSKTMYELA 103
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGAR-VTGVDISPEMLELA 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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