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Conserved domains on  [gi|1179685332|ref|NP_001337322|]
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complex I assembly factor TMEM126B, mitochondrial isoform e [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM126 super family cl06236
Transmembrane protein 126; This entry includes the transmembrane protein 126 A/B (TMEM126A/B) ...
 53-154 4.19e-52

Transmembrane protein 126; This entry includes the transmembrane protein 126 A/B (TMEM126A/B) from animals. Human TMEM126B participates in constructing the membrane arm of mitochondrial respiratory complex I.


The actual alignment was detected with superfamily member pfam07114:

Pssm-ID: 462092  Cd Length: 181  Bit Score: 163.58  E-value: 4.19e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685332  53 QTLLQDNISKENC-VFRSSLIGIVCGVFYPSSLAFTKNGRLATKYHTVPLPPKGRVLIHWMTLCQTQMKLMAIPLVFQIM 131
Cdd:pfam07114  79 DPLLSGDLNCEVCaVIRGGLVGVVCGGLYPIGLAFPKNGGLAARYHTAPLPPKGNVLRFWLKLSQPVFRKMSIPLVLQAV 158

                          90       100
                  ....*....|....*....|...
gi 1179685332 132 FGILNGLYHYAVFEETLEKTIHE 154
Cdd:pfam07114 159 FGAYLGSRHYEIYEKALELTEPE 181
 
Name Accession Description Interval E-value
TMEM126 pfam07114
Transmembrane protein 126; This entry includes the transmembrane protein 126 A/B (TMEM126A/B) ...
 53-154 4.19e-52

Transmembrane protein 126; This entry includes the transmembrane protein 126 A/B (TMEM126A/B) from animals. Human TMEM126B participates in constructing the membrane arm of mitochondrial respiratory complex I.


Pssm-ID: 462092  Cd Length: 181  Bit Score: 163.58  E-value: 4.19e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685332  53 QTLLQDNISKENC-VFRSSLIGIVCGVFYPSSLAFTKNGRLATKYHTVPLPPKGRVLIHWMTLCQTQMKLMAIPLVFQIM 131
Cdd:pfam07114  79 DPLLSGDLNCEVCaVIRGGLVGVVCGGLYPIGLAFPKNGGLAARYHTAPLPPKGNVLRFWLKLSQPVFRKMSIPLVLQAV 158

                          90       100
                  ....*....|....*....|...
gi 1179685332 132 FGILNGLYHYAVFEETLEKTIHE 154
Cdd:pfam07114 159 FGAYLGSRHYEIYEKALELTEPE 181
 
Name Accession Description Interval E-value
TMEM126 pfam07114
Transmembrane protein 126; This entry includes the transmembrane protein 126 A/B (TMEM126A/B) ...
 53-154 4.19e-52

Transmembrane protein 126; This entry includes the transmembrane protein 126 A/B (TMEM126A/B) from animals. Human TMEM126B participates in constructing the membrane arm of mitochondrial respiratory complex I.


Pssm-ID: 462092  Cd Length: 181  Bit Score: 163.58  E-value: 4.19e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685332  53 QTLLQDNISKENC-VFRSSLIGIVCGVFYPSSLAFTKNGRLATKYHTVPLPPKGRVLIHWMTLCQTQMKLMAIPLVFQIM 131
Cdd:pfam07114  79 DPLLSGDLNCEVCaVIRGGLVGVVCGGLYPIGLAFPKNGGLAARYHTAPLPPKGNVLRFWLKLSQPVFRKMSIPLVLQAV 158

                          90       100
                  ....*....|....*....|...
gi 1179685332 132 FGILNGLYHYAVFEETLEKTIHE 154
Cdd:pfam07114 159 FGAYLGSRHYEIYEKALELTEPE 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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