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Conserved domains on  [gi|1677529791|ref|NP_001339391|]
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zinc finger protein 133 isoform k [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
151-560 1.93e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 1.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677529791 151 NCGECGLSFSKMTNLLSHQRIHSGEKPYVCGV--CEKGFSLKKSLARHQKAHSGEKPIVCRECGRGFNRKSTLIIHERTH 228
Cdd:COG5048    35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSS 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677529791 229 SGE-KPYMCSECGRGFSQKSNLIIHQRTHSGEKPYVCRECGKGFSQKSavvrhQRTHLEEKTIVCSDCGLGFSDRSNLIS 307
Cdd:COG5048   115 SNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTP-----QSNSLHPPLPANSLSKDPSSNLSLLIS 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677529791 308 HQRTHSGEKPYACKECGRcFRQRTTLVNHQRTHSKEKPYVCGVCGHSFSQNSTLISHRRTHTGEKPYVCGVCGRGFSLKS 387
Cdd:COG5048   190 SNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677529791 388 HLNRHQNIHSGE-------KPIVCKDCGRGFSQQSNLIRHQRT--HSGE--KPMVCGE--CGRGFSQKSNLVAHQRTHSG 454
Cdd:COG5048   269 SSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677529791 455 ERPYVCRECGRGFSHQ-------AGLIRHKRKHSREKPYMC--RQCGLGFGNKSALITHKRAHSEEKPCVCRECGQGFLQ 525
Cdd:COG5048   349 ISPAKEKLLNSSSKFSpllnnepPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSF 428
                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1677529791 526 KSHLTL--HQMTHTGEKPYVCKTCGRgFSLKSHLSRH 560
Cdd:COG5048   429 NRHYNLipHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
151-560 1.93e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 1.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677529791 151 NCGECGLSFSKMTNLLSHQRIHSGEKPYVCGV--CEKGFSLKKSLARHQKAHSGEKPIVCRECGRGFNRKSTLIIHERTH 228
Cdd:COG5048    35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSS 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677529791 229 SGE-KPYMCSECGRGFSQKSNLIIHQRTHSGEKPYVCRECGKGFSQKSavvrhQRTHLEEKTIVCSDCGLGFSDRSNLIS 307
Cdd:COG5048   115 SNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTP-----QSNSLHPPLPANSLSKDPSSNLSLLIS 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677529791 308 HQRTHSGEKPYACKECGRcFRQRTTLVNHQRTHSKEKPYVCGVCGHSFSQNSTLISHRRTHTGEKPYVCGVCGRGFSLKS 387
Cdd:COG5048   190 SNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677529791 388 HLNRHQNIHSGE-------KPIVCKDCGRGFSQQSNLIRHQRT--HSGE--KPMVCGE--CGRGFSQKSNLVAHQRTHSG 454
Cdd:COG5048   269 SSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677529791 455 ERPYVCRECGRGFSHQ-------AGLIRHKRKHSREKPYMC--RQCGLGFGNKSALITHKRAHSEEKPCVCRECGQGFLQ 525
Cdd:COG5048   349 ISPAKEKLLNSSSKFSpllnnepPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSF 428
                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1677529791 526 KSHLTL--HQMTHTGEKPYVCKTCGRgFSLKSHLSRH 560
Cdd:COG5048   429 NRHYNLipHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
304-329 1.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.10e-03
                          10        20
                  ....*....|....*....|....*.
gi 1677529791 304 NLISHQRTHSGEKPYACKECGRCFRQ 329
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
151-560 1.93e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 1.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677529791 151 NCGECGLSFSKMTNLLSHQRIHSGEKPYVCGV--CEKGFSLKKSLARHQKAHSGEKPIVCRECGRGFNRKSTLIIHERTH 228
Cdd:COG5048    35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSS 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677529791 229 SGE-KPYMCSECGRGFSQKSNLIIHQRTHSGEKPYVCRECGKGFSQKSavvrhQRTHLEEKTIVCSDCGLGFSDRSNLIS 307
Cdd:COG5048   115 SNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTP-----QSNSLHPPLPANSLSKDPSSNLSLLIS 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677529791 308 HQRTHSGEKPYACKECGRcFRQRTTLVNHQRTHSKEKPYVCGVCGHSFSQNSTLISHRRTHTGEKPYVCGVCGRGFSLKS 387
Cdd:COG5048   190 SNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677529791 388 HLNRHQNIHSGE-------KPIVCKDCGRGFSQQSNLIRHQRT--HSGE--KPMVCGE--CGRGFSQKSNLVAHQRTHSG 454
Cdd:COG5048   269 SSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677529791 455 ERPYVCRECGRGFSHQ-------AGLIRHKRKHSREKPYMC--RQCGLGFGNKSALITHKRAHSEEKPCVCRECGQGFLQ 525
Cdd:COG5048   349 ISPAKEKLLNSSSKFSpllnnepPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSF 428
                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1677529791 526 KSHLTL--HQMTHTGEKPYVCKTCGRgFSLKSHLSRH 560
Cdd:COG5048   429 NRHYNLipHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
232-580 1.91e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.72  E-value: 1.91e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677529791 232 KPYMCSECGRGFSQKSNLIIHQRTHSGEKPYVCR--ECGKGFSQKSAVVRHQRTHLEEKTIVCSDCGLG--FSDRSNLIS 307
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677529791 308 HQRTHSgEKPYACKECGRCFRQRTTLVNHQRTHSKEKPYVCGVCGHSFSQ----NSTLISHRRTHTGEKPYVCgvcgrgf 383
Cdd:COG5048   112 SSSSNS-NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsNSLHPPLPANSLSKDPSSN------- 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677529791 384 slkSHLNRHQNIHSGEKPIVCKDCGRGFSQQSNLIRHQRTHSGEKPMVCGECGRGFSQKSNLVAHQRTHSGERPYVCREC 463
Cdd:COG5048   184 ---LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677529791 464 GRGFSHQAGLIRHKRKHS-------REKPYMCRQCGLGFGNKSALITHKRA--HSEE--KPCVCRE--CGQGFLQKSHLT 530
Cdd:COG5048   261 PRSSLPTASSQSSSPNESdsssekgFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALK 340
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1677529791 531 LHQMTHTGEKPYVCKTCGRGfSLKSHLSRHRKTTSVHHRLPVQPDPEPCA 580
Cdd:COG5048   341 RHILLHTSISPAKEKLLNSS-SKFSPLLNNEPPQSLQQYKDLKNDKKSET 389
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
352-432 1.69e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677529791 352 GHSFSQNSTLISHRRTHT------GEKPYVCGVCGRGFSLKSHLNRHQNIHSGEKPIVCKDCGRG--FSQQSNLIRHQRT 423
Cdd:COG5048     6 SQSSSSNNSVLSSTPKSTlkslsnAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRT 85

                  ....*....
gi 1677529791 424 HSGEKPMVC 432
Cdd:COG5048    86 HHNNPSDLN 94
zf-H2C2_2 pfam13465
Zinc-finger double domain;
304-329 1.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.10e-03
                          10        20
                  ....*....|....*....|....*.
gi 1677529791 304 NLISHQRTHSGEKPYACKECGRCFRQ 329
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
248-273 1.77e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.77e-03
                          10        20
                  ....*....|....*....|....*.
gi 1677529791 248 NLIIHQRTHSGEKPYVCRECGKGFSQ 273
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
403-424 2.08e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.08e-03
                          10        20
                  ....*....|....*....|..
gi 1677529791 403 VCKDCGRGFSQQSNLIRHQRTH 424
Cdd:pfam00096   2 KCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
234-256 2.17e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.17e-03
                          10        20
                  ....*....|....*....|...
gi 1677529791 234 YMCSECGRGFSQKSNLIIHQRTH 256
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
164-188 6.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.04e-03
                          10        20
                  ....*....|....*....|....*
gi 1677529791 164 NLLSHQRIHSGEKPYVCGVCEKGFS 188
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
444-469 7.65e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.65e-03
                          10        20
                  ....*....|....*....|....*.
gi 1677529791 444 NLVAHQRTHSGERPYVCRECGRGFSH 469
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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