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Conserved domains on  [gi|1214884402|ref|NP_001340310|]
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zinc finger protein 843 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 10442881)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0003677|GO:0008270|GO:0003700
PubMed:  11179890|12665246|11361095|10940247|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 163-334 2.17e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 2.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214884402  163 RVLPHPGEKTCRGGSVESVSLAPSSVAPDSTSGLRPCGSPGSFLQHLP-PSTLLPRPPFLYPGPPLSLQPLVPSGLPAVP 241
Cdd:PHA03247  2775 PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAsPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGG 2854

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214884402  242 AVPLGGlEVAQVPPATQPAAQQEGAMGPRscasAGRDSREAVQAPGYPEPARKASQHRAAGPLGEARARLQRQCRAPPPP 321
Cdd:PHA03247  2855 SVAPGG-DVRRRPPSRSPAAKPAAPARPP----VRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQP 2929

                          170
                   ....*....|...
gi 1214884402  322 SNPHWRGALPVFP 334
Cdd:PHA03247  2930 QPPPPPPPRPQPP 2942
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 33-55 7.60e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.43  E-value: 7.60e-03
                          10        20
                  ....*....|....*....|...
gi 1214884402  33 CKCKACGRGFTQSASLLQHWRVH 55
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 163-334 2.17e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 2.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214884402  163 RVLPHPGEKTCRGGSVESVSLAPSSVAPDSTSGLRPCGSPGSFLQHLP-PSTLLPRPPFLYPGPPLSLQPLVPSGLPAVP 241
Cdd:PHA03247  2775 PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAsPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGG 2854

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214884402  242 AVPLGGlEVAQVPPATQPAAQQEGAMGPRscasAGRDSREAVQAPGYPEPARKASQHRAAGPLGEARARLQRQCRAPPPP 321
Cdd:PHA03247  2855 SVAPGG-DVRRRPPSRSPAAKPAAPARPP----VRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQP 2929

                          170
                   ....*....|...
gi 1214884402  322 SNPHWRGALPVFP 334
Cdd:PHA03247  2930 QPPPPPPPRPQPP 2942
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 33-55 7.60e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.43  E-value: 7.60e-03
                          10        20
                  ....*....|....*....|...
gi 1214884402  33 CKCKACGRGFTQSASLLQHWRVH 55
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 163-334 2.17e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 2.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214884402  163 RVLPHPGEKTCRGGSVESVSLAPSSVAPDSTSGLRPCGSPGSFLQHLP-PSTLLPRPPFLYPGPPLSLQPLVPSGLPAVP 241
Cdd:PHA03247  2775 PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAsPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGG 2854

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214884402  242 AVPLGGlEVAQVPPATQPAAQQEGAMGPRscasAGRDSREAVQAPGYPEPARKASQHRAAGPLGEARARLQRQCRAPPPP 321
Cdd:PHA03247  2855 SVAPGG-DVRRRPPSRSPAAKPAAPARPP----VRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQP 2929

                          170
                   ....*....|...
gi 1214884402  322 SNPHWRGALPVFP 334
Cdd:PHA03247  2930 QPPPPPPPRPQPP 2942
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
224-324 4.51e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 39.06  E-value: 4.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214884402 224 GPPLSLQPLVPSGLPAVPAVPLGGLEVAQVPPATQPAAQQEGAMGPRSCASAGRDSREAVQAPGYPEPARKASQHRAAGP 303
Cdd:PRK07003  367 APGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGD 446

                          90       100
                  ....*....|....*....|....*...
gi 1214884402 304 L-------GEARARLQRQCRAPPPPSNP 324
Cdd:PRK07003  447 ApvpakanARASADSRCDERDAQPPADS 474
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 211-339 5.57e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 38.69  E-value: 5.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214884402 211 PSTLLPRPPflypGPPLSLQPLVPSGLPAVPAVPLGGLEVAQVPPATQPAAQQEGAMGPRSCASAGRDSREAVQAPGYPE 290
Cdd:PRK07994  361 PAAPLPEPE----VPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGAT 436

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1214884402 291 PARKASQHRAAGPlGEARARLQRQCRAPPPPSNPHWRGALPVFPVWKAS 339
Cdd:PRK07994  437 KAKKSEPAAASRA-RPVNSALERLASVRPAPSALEKAPAKKEAYRWKAT 484
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 33-55 7.60e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.43  E-value: 7.60e-03
                          10        20
                  ....*....|....*....|...
gi 1214884402  33 CKCKACGRGFTQSASLLQHWRVH 55
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
187-335 8.51e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 37.93  E-value: 8.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214884402 187 SVAPDSTSG----------LRPCGSPGsflQHLPPSTLL-----PRPPFLYPGPPLSLQPLVPSGLPAVPAVPLGGLEVA 251
Cdd:PRK12323  344 ALAPDEYAGftmtllrmlaFRPGQSGG---GAGPATAAAapvaqPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVA 420

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214884402 252 QVPPATQPAAQQEGAMGPRSCASAGRDSREAVQAPGYPEPARKASqhrAAGPLGEARARLQRQCR-------APPPPSNP 324
Cdd:PRK12323  421 AAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPA---AAGPRPVAAAAAAAPARaapaaapAPADDDPP 497

                         170
                  ....*....|.
gi 1214884402 325 HWRGALPVFPV 335
Cdd:PRK12323  498 PWEELPPEFAS 508
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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