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Conserved domains on  [gi|1219862402|ref|NP_001340727|]
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zinc finger protein 846 isoform 2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
2-367 3.54e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 3.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862402   2 THMITHIGEKTSEDNQSGKALRKNFPHSFYKKSHAEGKMPKCVKHEKAFNQFPNLTRQNKTHTQEKLCECKDC--WRTFL 79
Cdd:COG5048    82 HLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsSSVNT 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862402  80 NQSSLKLHIRSHNgdkhyvcKECGKAFSNSSHLIGHGRIHSGEKPYVCKECGKAFTQSTGLKLHIRTHSgEKPYKCKECG 159
Cdd:COG5048   162 PQSNSLHPPLPAN-------SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNS 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862402 160 KAFTHS------SYLTDHTRIHSGKKPYVCMECGKAFTRSTGLILHMRIHTG-EKPYECKECGKAFIHSSYLTKHVR--I 230
Cdd:COG5048   234 QLSPKSllsqspSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvN 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862402 231 HSGEKL--YLCKA--CGKAFTRSSGLVLHMRTHTGEKPYECK--ECGKAFN------NSSMLSQHVRIHTgEKPYEC--K 296
Cdd:COG5048   314 HSGESLkpFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSpllnnePPQSLQQYKDLKN-DKKSETlsN 392

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1219862402 297 ECGKAFTQSSGLSTHLRTHT--GEKACECKECGKAFARSTNLNMHMRTHTGEKPYACKECGKAFRYSTYLNVH 367
Cdd:COG5048   393 SCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHG 465
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
2-367 3.54e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 3.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862402   2 THMITHIGEKTSEDNQSGKALRKNFPHSFYKKSHAEGKMPKCVKHEKAFNQFPNLTRQNKTHTQEKLCECKDC--WRTFL 79
Cdd:COG5048    82 HLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsSSVNT 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862402  80 NQSSLKLHIRSHNgdkhyvcKECGKAFSNSSHLIGHGRIHSGEKPYVCKECGKAFTQSTGLKLHIRTHSgEKPYKCKECG 159
Cdd:COG5048   162 PQSNSLHPPLPAN-------SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNS 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862402 160 KAFTHS------SYLTDHTRIHSGKKPYVCMECGKAFTRSTGLILHMRIHTG-EKPYECKECGKAFIHSSYLTKHVR--I 230
Cdd:COG5048   234 QLSPKSllsqspSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvN 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862402 231 HSGEKL--YLCKA--CGKAFTRSSGLVLHMRTHTGEKPYECK--ECGKAFN------NSSMLSQHVRIHTgEKPYEC--K 296
Cdd:COG5048   314 HSGESLkpFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSpllnnePPQSLQQYKDLKN-DKKSETlsN 392

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1219862402 297 ECGKAFTQSSGLSTHLRTHT--GEKACECKECGKAFARSTNLNMHMRTHTGEKPYACKECGKAFRYSTYLNVH 367
Cdd:COG5048   393 SCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHG 465
zf-H2C2_2 pfam13465
Zinc-finger double domain;
335-360 1.22e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.22e-04
                          10        20
                  ....*....|....*....|....*.
gi 1219862402 335 NLNMHMRTHTGEKPYACKECGKAFRY 360
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 124-171 1.48e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 38.32  E-value: 1.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1219862402 124 PYVCKECGKAFTQSTGLKLHIRTHSGEKpyKCKECGKAFTHSSYLTDH 171
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
2-367 3.54e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 3.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862402   2 THMITHIGEKTSEDNQSGKALRKNFPHSFYKKSHAEGKMPKCVKHEKAFNQFPNLTRQNKTHTQEKLCECKDC--WRTFL 79
Cdd:COG5048    82 HLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsSSVNT 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862402  80 NQSSLKLHIRSHNgdkhyvcKECGKAFSNSSHLIGHGRIHSGEKPYVCKECGKAFTQSTGLKLHIRTHSgEKPYKCKECG 159
Cdd:COG5048   162 PQSNSLHPPLPAN-------SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNS 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862402 160 KAFTHS------SYLTDHTRIHSGKKPYVCMECGKAFTRSTGLILHMRIHTG-EKPYECKECGKAFIHSSYLTKHVR--I 230
Cdd:COG5048   234 QLSPKSllsqspSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvN 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862402 231 HSGEKL--YLCKA--CGKAFTRSSGLVLHMRTHTGEKPYECK--ECGKAFN------NSSMLSQHVRIHTgEKPYEC--K 296
Cdd:COG5048   314 HSGESLkpFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSpllnnePPQSLQQYKDLKN-DKKSETlsN 392

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1219862402 297 ECGKAFTQSSGLSTHLRTHT--GEKACECKECGKAFARSTNLNMHMRTHTGEKPYACKECGKAFRYSTYLNVH 367
Cdd:COG5048   393 SCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
79-398 3.93e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 3.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862402  79 LNQSSLKLHIRSHNGDKHYVCKECGKAFSNSSHLIGHGRIHSGEKPYVCKECGKAFTQSTGLKL--HIRTHSGE------ 150
Cdd:COG5048    16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNpsdlns 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862402 151 -----------------------KPYKCKECGKAFTHSSYLTDHTRIHS---GKKPYVCMECGKAFTRSTGLILHMRIHT 204
Cdd:COG5048    96 kslplsnskasssslsssssnsnDNNLLSSHSLPPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTPQSNSLHPPLPANS 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862402 205 gekpyeckECGKAFIHSSYLTKHVRIHSGEKLYLCKACGKAFTRSSGLVLHMRTHTgEKPYECKECGKAFNNSSMLSQHV 284
Cdd:COG5048   176 --------LSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPS 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862402 285 RIHTGEKPYECKECG------KAFTQSSGLSTHLRTHTG-EKACECKECGKAFARSTNLNMHMRT--HTGE--KPYACKE 353
Cdd:COG5048   247 SLSSSDSSSSASESPrsslptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPY 326

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1219862402 354 --CGKAFRYSTYLNVHTRTHTGAKPYECK--KCGKNFTQSSALAKHLRT 398
Cdd:COG5048   327 slCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSL 375
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
42-352 2.51e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 2.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862402  42 KCVKHEKAFNQFPNLTRQNKTHTQEKLCECKDCWRT--FLNQSSLKLHIRSHNGDKHYVC--KECGKAFSNSSHLIGHGR 117
Cdd:COG5048    35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSLSSSS 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862402 118 IHSgekPYVCKECGKAFTQSTGLKLHI----RTHSGEKPYK-CKECGKAFTHSSYLTDHTRIHSGKKPYvcmecgkafTR 192
Cdd:COG5048   115 SNS---NDNNLLSSHSLPPSSRDPQLPdllsISNLRNNPLPgNNSSSVNTPQSNSLHPPLPANSLSKDP---------SS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862402 193 STGLILHMRIHTGEK-PYECKECGKAFIHSSYLTKHVRIHSgEKLYLCKACGKAFTRSSGLVLHMRTHTGEKPYECKECG 271
Cdd:COG5048   183 NLSLLISSNVSTSIPsSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862402 272 KAFNNSSMLSQHVRIHTGE-------KPYECKECGKAFTQSSGLSTHLRT--HTGE--KACECKE--CGKAFARSTNLNM 338
Cdd:COG5048   262 RSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKR 341

                         330
                  ....*....|....
gi 1219862402 339 HMRTHTGEKPYACK 352
Cdd:COG5048   342 HILLHTSISPAKEK 355
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 121-199 1.03e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862402 121 GEKPYVCK--ECGKAFTQSTGLKLHiRTHSGEKPykckecgkaFTHSSYLTDHTRIHSGK-KPYVCMECGKAFTRSTGLI 197
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQ---------KLHENPSPEKMNIFSAKdKPYRCEVCDKRYKNLNGLK 415


                  ..
gi 1219862402 198 LH 199
Cdd:COG5189   416 YH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
335-360 1.22e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.22e-04
                          10        20
                  ....*....|....*....|....*.
gi 1219862402 335 NLNMHMRTHTGEKPYACKECGKAFRY 360
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 69-148 1.41e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 1.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862402  69 CECKDCWRTFLNQSSLKLHiRSHNgdkhyvckECGKAFSNSSHLIGHGRIHSGEKPYVCKECGKAFTQSTGLKLHiRTHS 148
Cdd:COG5189   352 CPVEGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
279-304 2.86e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.86e-04
                          10        20
                  ....*....|....*....|....*.
gi 1219862402 279 MLSQHVRIHTGEKPYECKECGKAFTQ 304
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
252-276 4.91e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 4.91e-04
                          10        20
                  ....*....|....*....|....*
gi 1219862402 252 LVLHMRTHTGEKPYECKECGKAFNN 276
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
140-164 5.42e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.42e-04
                          10        20
                  ....*....|....*....|....*
gi 1219862402 140 LKLHIRTHSGEKPYKCKECGKAFTH 164
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
196-220 9.38e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 9.38e-04
                          10        20
                  ....*....|....*....|....*
gi 1219862402 196 LILHMRIHTGEKPYECKECGKAFIH 220
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 124-171 1.48e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 38.32  E-value: 1.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1219862402 124 PYVCKECGKAFTQSTGLKLHIRTHSGEKpyKCKECGKAFTHSSYLTDH 171
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 233-316 7.29e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.55  E-value: 7.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862402 233 GEKLYLCK--ACGKAFTRSSGLVLHMRT-HTGEKPYECKECGKafnnssmlsqHVRIHTGEKPYECKECGKAFTQSSGLS 309
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 1219862402 310 THlRTHT 316
Cdd:COG5189   416 YH-RKHS 421
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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