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Conserved domains on  [gi|1237938304|ref|NP_001341333|]
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protocadherin-15 isoform CD1-a precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ECD super family cl39769
Extracellular Cadherin domain; This is an extracellular cadherin (EC) domain which can be ...
 30-118 2.80e-47

Extracellular Cadherin domain; This is an extracellular cadherin (EC) domain which can be found at the N-terminal region of Protocadherin 15 (Pcdh15). Pcdh15 features exceptionally long extracellular domains containing 11 ECs. These repeats are structurally similar, but not identical in sequence, often featuring linkers with conserved calcium-binding sites that confer mechanical strength to them.


The actual alignment was detected with superfamily member pfam18432:

Pssm-ID: 408229  Cd Length: 110  Bit Score: 164.88  E-value: 2.80e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304   30 DGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH 109
Cdd:pfam18432   22 NGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCVNKKVGTVIYH 101


                   ....*....
gi 1237938304  110 EVRIVVRDR 118
Cdd:pfam18432  102 EVRIVVRDR 110
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 599-691 1.10e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 1.10e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  599 YSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPD 674
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDgGGPP 81

                           90
                   ....*....|....*..
gi 1237938304  675 GTSTATVNIVVTDVNDN 691
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 700-793 2.67e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 2.67e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  700 PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVH 775
Cdd:cd11304      1 SYEVSVPENAPpGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1237938304  776 PRHSTLTLAIKVLDIDDN 793
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 801-899 1.08e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.00  E-value: 1.08e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  801 TYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEafpdQEASITFLVEAFD 878
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|.
gi 1237938304  879 IYGTMPPGIATVTVIVKDMND 899
Cdd:cd11304     77 GGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1023-1118 1.68e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.84  E-value: 1.68e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304 1023 VSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAdslevvlANLR 1098
Cdd:cd11304      6 VPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTA-------TDGG 78

                           90       100
                   ....*....|....*....|
gi 1237938304 1099 VPSKSNTAKVYIEIQDENNH 1118
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 491-587 2.04e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.98  E-value: 2.04e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  491 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP 569
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGnEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1237938304  570 aeRRNSICTVYIEVLPPN 587
Cdd:cd11304     81 --PLSSTATVTITVLDVN 96
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 908-1005 6.34e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 6.34e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  908 IYKGMVAPDAVKGTPITTVYAEDADPPglPASRVRYRVDDVQfpyPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF 987
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                           90
                   ....*....|....*...
gi 1237938304  988 DDGEPVMSSSATVKILVL 1005
Cdd:cd11304     76 DGGGPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 377-483 3.11e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.03  E-value: 3.11e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  377 SYQGYILESAPVGATIsdslnltspLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGItryLTLLQPVDREEQQTY 455
Cdd:cd11304      1 SYEVSVPENAPPGTVV---------LTVSATDPDSGENGEVTYSIVSGNEDGLFSIdPSTGE---ITTAKPLDREEQSSY 68

                           90       100       110
                   ....*....|....*....|....*....|
gi 1237938304  456 TFSITAFDGVQE--SEPVIVNIQVMDANDN 483
Cdd:cd11304     69 TLTVTATDGGGPplSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 129-218 2.39e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.64  E-value: 2.39e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  129 SYYATVNELTPVGTTIFTgFSgdngATDIDDGPNGQIEYVIQynpdDPTSNDTFEI-PLmlTGNIVLRKRLNYEDKTRYF 207
Cdd:cd11304      1 SYEVSVPENAPPGTVVLT-VS----ATDPDSGENGEVTYSIV----SGNEDGLFSIdPS--TGEITTAKPLDREEQSSYT 69

                           90
                   ....*....|.
gi 1237938304  208 VIIQANDRAQN 218
Cdd:cd11304     70 LTVTATDGGGP 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1127-1221 2.64e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.64  E-value: 2.64e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304 1127 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPikeGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDY 1206
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90
                   ....*....|....*
gi 1237938304 1207 GKGLSGKADVLVSVV 1221
Cdd:cd11304     79 GPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 283-371 1.85e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.43  E-value: 1.85e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304   283 QAIDQDRNiqppsDRPGILYSILvgtPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIE 362
Cdd:smart00112    1 SATDADSG-----ENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                    ....*....
gi 1237938304   363 ILDENNQSP 371
Cdd:smart00112   73 VLDVNDNAP 81
 
Name Accession Description Interval E-value
ECD pfam18432
Extracellular Cadherin domain; This is an extracellular cadherin (EC) domain which can be ...
 30-118 2.80e-47

Extracellular Cadherin domain; This is an extracellular cadherin (EC) domain which can be found at the N-terminal region of Protocadherin 15 (Pcdh15). Pcdh15 features exceptionally long extracellular domains containing 11 ECs. These repeats are structurally similar, but not identical in sequence, often featuring linkers with conserved calcium-binding sites that confer mechanical strength to them.


Pssm-ID: 408229  Cd Length: 110  Bit Score: 164.88  E-value: 2.80e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304   30 DGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH 109
Cdd:pfam18432   22 NGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCVNKKVGTVIYH 101


                   ....*....
gi 1237938304  110 EVRIVVRDR 118
Cdd:pfam18432  102 EVRIVVRDR 110
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 599-691 1.10e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 1.10e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  599 YSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPD 674
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDgGGPP 81

                           90
                   ....*....|....*..
gi 1237938304  675 GTSTATVNIVVTDVNDN 691
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 700-793 2.67e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 2.67e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  700 PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVH 775
Cdd:cd11304      1 SYEVSVPENAPpGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1237938304  776 PRHSTLTLAIKVLDIDDN 793
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 801-899 1.08e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.00  E-value: 1.08e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  801 TYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEafpdQEASITFLVEAFD 878
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|.
gi 1237938304  879 IYGTMPPGIATVTVIVKDMND 899
Cdd:cd11304     77 GGGPPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 718-795 7.28e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 91.26  E-value: 7.28e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304   718 KATDPDAGINGQVHYSL--GNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 794
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1237938304   795 P 795
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1023-1118 1.68e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.84  E-value: 1.68e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304 1023 VSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAdslevvlANLR 1098
Cdd:cd11304      6 VPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTA-------TDGG 78

                           90       100
                   ....*....|....*....|
gi 1237938304 1099 VPSKSNTAKVYIEIQDENNH 1118
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 617-693 3.88e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.55  E-value: 3.88e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304   617 QATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNA 692
Cdd:smart00112    1 SATDADSGEngkVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDgGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1237938304   693 P 693
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
706-788 1.04e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.73  E-value: 1.04e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  706 VEEEA--NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 780
Cdd:pfam00028    5 VPENApvGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIdPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                   ....*...
gi 1237938304  781 LTLAIKVL 788
Cdd:pfam00028   85 ATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 491-587 2.04e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.98  E-value: 2.04e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  491 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP 569
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGnEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1237938304  570 aeRRNSICTVYIEVLPPN 587
Cdd:cd11304     81 --PLSSTATVTITVLDVN 96
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1042-1120 2.96e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.16  E-value: 2.96e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1237938304  1042 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAdslevvlANLRVPSKSNTAKVYIEIQDENNHPP 1120
Cdd:smart00112   10 NGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEA-------TDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
599-686 6.91e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.34  E-value: 6.91e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  599 YSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPD 674
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpngRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDsGGPP 80

                           90
                   ....*....|..
gi 1237938304  675 GTSTATVNIVVT 686
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 908-1005 6.34e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 6.34e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  908 IYKGMVAPDAVKGTPITTVYAEDADPPglPASRVRYRVDDVQfpyPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF 987
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                           90
                   ....*....|....*...
gi 1237938304  988 DDGEPVMSSSATVKILVL 1005
Cdd:cd11304     76 DGGGPPLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
1023-1113 3.70e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.72  E-value: 3.70e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304 1023 VSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAdslevvlANLR 1098
Cdd:pfam00028    5 VPENAPVGTEVLTVTAtdpdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA-------TDSG 77

                           90
                   ....*....|....*
gi 1237938304 1099 VPSKSNTAKVYIEIQ 1113
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
802-894 6.39e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 6.39e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  802 YTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEafpdQEASITFLVEAFDI 879
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNgrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRE----SIGEYELTVEATDS 76

                           90
                   ....*....|....*
gi 1237938304  880 YGTMPPGIATVTVIV 894
Cdd:pfam00028   77 GGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 377-483 3.11e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.03  E-value: 3.11e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  377 SYQGYILESAPVGATIsdslnltspLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGItryLTLLQPVDREEQQTY 455
Cdd:cd11304      1 SYEVSVPENAPPGTVV---------LTVSATDPDSGENGEVTYSIVSGNEDGLFSIdPSTGE---ITTAKPLDREEQSSY 68

                           90       100       110
                   ....*....|....*....|....*....|
gi 1237938304  456 TFSITAFDGVQE--SEPVIVNIQVMDANDN 483
Cdd:cd11304     69 TLTVTATDGGGPplSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 821-902 3.27e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.30  E-value: 3.27e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304   821 AKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEafpdQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 898
Cdd:smart00112    2 ATDADSGENgkVTYSILSGNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1237938304   899 DYPP 902
Cdd:smart00112   78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 129-218 2.39e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.64  E-value: 2.39e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  129 SYYATVNELTPVGTTIFTgFSgdngATDIDDGPNGQIEYVIQynpdDPTSNDTFEI-PLmlTGNIVLRKRLNYEDKTRYF 207
Cdd:cd11304      1 SYEVSVPENAPPGTVVLT-VS----ATDPDSGENGEVTYSIV----SGNEDGLFSIdPS--TGEITTAKPLDREEQSSYT 69

                           90
                   ....*....|.
gi 1237938304  208 VIIQANDRAQN 218
Cdd:cd11304     70 LTVTATDGGGP 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1127-1221 2.64e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.64  E-value: 2.64e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304 1127 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPikeGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDY 1206
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90
                   ....*....|....*
gi 1237938304 1207 GKGLSGKADVLVSVV 1221
Cdd:cd11304     79 GPPLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
916-1005 2.76e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.24  E-value: 2.76e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  916 DAVKGTPITTVYAEDADPPglPASRVRYRVddvQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS 995
Cdd:pfam00028    8 NAPVGTEVLTVTATDPDLG--PNGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                           90
                   ....*....|
gi 1237938304  996 SSATVKILVL 1005
Cdd:pfam00028   83 STATVTITVL 92
Cadherin pfam00028
Cadherin domain;
492-584 4.33e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.86  E-value: 4.33e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  492 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 570
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|....
gi 1237938304  571 erRNSICTVYIEVL 584
Cdd:pfam00028   81 --LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 510-591 2.61e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.21  E-value: 2.61e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304   510 TAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPaeRRNSICTVYIEVLPPNN 588
Cdd:smart00112    1 SATDADSGENGKVTYSILSGnDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP--PLSSTATVTITVLDVND 78


                    ...
gi 1237938304   589 QSP 591
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 928-1005 5.07e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.74  E-value: 5.07e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1237938304   928 AEDADPPglPASRVRYRVDDvqfPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL 1005
Cdd:smart00112    2 ATDADSG--ENGKVTYSILS---GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 405-485 7.36e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.28  E-value: 7.36e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304   405 VALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGItryLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDAN 481
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIdPETGE---ITTTKPLDREEQPEYTLTVEATDGGGPplSSTATVTITVLDVN 77


                    ....
gi 1237938304   482 DNTP 485
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 154-218 6.38e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.58  E-value: 6.38e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1237938304   154 ATDIDDGPNGQIEYVIQYNPDDptsnDTFEIpLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 218
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDD----GLFSI-DPETGEITTTKPLDREEQPEYTLTVEATDGGGP 61
Cadherin pfam00028
Cadherin domain;
130-217 7.43e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 7.43e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  130 YYATVNELTPVGTTIFTgfsgdNGATDIDDGPNGQIEYVIQYNPddptSNDTFEI-PlmLTGNIVLRKRLNYEDKTRYFV 208
Cdd:pfam00028    1 YSASVPENAPVGTEVLT-----VTATDPDLGPNGRIFYSILGGG----PGGNFRIdP--DTGDISTTKPLDRESIGEYEL 69


                   ....*....
gi 1237938304  209 IIQANDRAQ 217
Cdd:pfam00028   70 TVEATDSGG 78
Cadherin pfam00028
Cadherin domain;
1131-1220 1.49e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.76  E-value: 1.49e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304 1131 VSEDARMFTSVLRVKATDKDTGNYSVMAYRliippIKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGK 1208
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYS-----ILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|..
gi 1237938304 1209 GLSGKADVLVSV 1220
Cdd:pfam00028   80 PLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 283-371 1.85e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.43  E-value: 1.85e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304   283 QAIDQDRNiqppsDRPGILYSILvgtPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIE 362
Cdd:smart00112    1 SATDADSG-----ENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                    ....*....
gi 1237938304   363 ILDENNQSP 371
Cdd:smart00112   73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
378-477 6.68e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.22  E-value: 6.68e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  378 YQGYILESAPVGatisdslnlTSPLRIVALDKDIEDTKDPElHLFLNDYTS-VFTVTQtgITRYLTLLQPVDREEQQTYT 456
Cdd:pfam00028    1 YSASVPENAPVG---------TEVLTVTATDPDLGPNGRIF-YSILGGGPGgNFRIDP--DTGDISTTKPLDRESIGEYE 68

                           90       100
                   ....*....|....*....|...
gi 1237938304  457 FSITAFDGVQE--SEPVIVNIQV 477
Cdd:pfam00028   69 LTVEATDSGGPplSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1145-1225 1.80e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.65  E-value: 1.80e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  1145 KATDKDTGNYSVMAYRLIIPPikeGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1224
Cdd:smart00112    1 SATDADSGENGKVTYSILSGN---DDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    .
gi 1237938304  1225 D 1225
Cdd:smart00112   78 D 78
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 453-723 1.37e-04

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 47.34  E-value: 1.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  453 QTYTFSITAFDGVQESEPVIVNIQVmdANDNTPTFPEISYDVYVytdmRPGDSV-IQLTAVDADegsNGEITYE-ILVGA 530
Cdd:NF038112  1252 TVLTFQLVVSDGTKTSAPDTVTVLV--RNVNRAPVAVAGAPATV----DERSTVtLDGSGTDAD---GDALTYAwTQTSG 1322

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  531 QGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAerrnsicTVYIEVLPPNnqsppRFPQLMYSLEISEAMRv 609
Cdd:NF038112  1323 PAVTLTGATTATATfTAPEVTADTQLTFTLTVSDGTASATD-------TVTVTVRNVN-----RAPVANAGADQTVDER- 1389

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  610 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTL-GKALDRESTDRYILIITAsdgrpDGTSTATVNIVVTDV 688
Cdd:NF038112  1390 STVTLSGSATDPDGDALTYAWTQTAGPTVTLTGADTATASFtAPEVAADTELTFQLTVSA-----DGQASADVTVTVTVR 1464

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 1237938304  689 NDN-APVFDpylPRNLSVVEEEANAFVgQVKATDPD 723
Cdd:NF038112  1465 NVNrAPVAH---AGESITVDEGSTVTL-DASATDPD 1496
 
Name Accession Description Interval E-value
ECD pfam18432
Extracellular Cadherin domain; This is an extracellular cadherin (EC) domain which can be ...
 30-118 2.80e-47

Extracellular Cadherin domain; This is an extracellular cadherin (EC) domain which can be found at the N-terminal region of Protocadherin 15 (Pcdh15). Pcdh15 features exceptionally long extracellular domains containing 11 ECs. These repeats are structurally similar, but not identical in sequence, often featuring linkers with conserved calcium-binding sites that confer mechanical strength to them.


Pssm-ID: 408229  Cd Length: 110  Bit Score: 164.88  E-value: 2.80e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304   30 DGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH 109
Cdd:pfam18432   22 NGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCVNKKVGTVIYH 101


                   ....*....
gi 1237938304  110 EVRIVVRDR 118
Cdd:pfam18432  102 EVRIVVRDR 110
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 599-691 1.10e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 1.10e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  599 YSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPD 674
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDgGGPP 81

                           90
                   ....*....|....*..
gi 1237938304  675 GTSTATVNIVVTDVNDN 691
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 700-793 2.67e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 2.67e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  700 PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVH 775
Cdd:cd11304      1 SYEVSVPENAPpGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1237938304  776 PRHSTLTLAIKVLDIDDN 793
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 801-899 1.08e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.00  E-value: 1.08e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  801 TYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEafpdQEASITFLVEAFD 878
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|.
gi 1237938304  879 IYGTMPPGIATVTVIVKDMND 899
Cdd:cd11304     77 GGGPPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 718-795 7.28e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 91.26  E-value: 7.28e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304   718 KATDPDAGINGQVHYSL--GNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 794
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1237938304   795 P 795
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1023-1118 1.68e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.84  E-value: 1.68e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304 1023 VSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAdslevvlANLR 1098
Cdd:cd11304      6 VPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTA-------TDGG 78

                           90       100
                   ....*....|....*....|
gi 1237938304 1099 VPSKSNTAKVYIEIQDENNH 1118
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 617-693 3.88e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.55  E-value: 3.88e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304   617 QATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNA 692
Cdd:smart00112    1 SATDADSGEngkVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDgGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1237938304   693 P 693
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
706-788 1.04e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.73  E-value: 1.04e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  706 VEEEA--NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 780
Cdd:pfam00028    5 VPENApvGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIdPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                   ....*...
gi 1237938304  781 LTLAIKVL 788
Cdd:pfam00028   85 ATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 491-587 2.04e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.98  E-value: 2.04e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  491 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP 569
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGnEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1237938304  570 aeRRNSICTVYIEVLPPN 587
Cdd:cd11304     81 --PLSSTATVTITVLDVN 96
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1042-1120 2.96e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.16  E-value: 2.96e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1237938304  1042 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAdslevvlANLRVPSKSNTAKVYIEIQDENNHPP 1120
Cdd:smart00112   10 NGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEA-------TDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
599-686 6.91e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.34  E-value: 6.91e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  599 YSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPD 674
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpngRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDsGGPP 80

                           90
                   ....*....|..
gi 1237938304  675 GTSTATVNIVVT 686
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 908-1005 6.34e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 6.34e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  908 IYKGMVAPDAVKGTPITTVYAEDADPPglPASRVRYRVDDVQfpyPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF 987
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                           90
                   ....*....|....*...
gi 1237938304  988 DDGEPVMSSSATVKILVL 1005
Cdd:cd11304     76 DGGGPPLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
1023-1113 3.70e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.72  E-value: 3.70e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304 1023 VSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAdslevvlANLR 1098
Cdd:pfam00028    5 VPENAPVGTEVLTVTAtdpdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA-------TDSG 77

                           90
                   ....*....|....*
gi 1237938304 1099 VPSKSNTAKVYIEIQ 1113
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
802-894 6.39e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 6.39e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  802 YTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEafpdQEASITFLVEAFDI 879
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNgrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRE----SIGEYELTVEATDS 76

                           90
                   ....*....|....*
gi 1237938304  880 YGTMPPGIATVTVIV 894
Cdd:pfam00028   77 GGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 377-483 3.11e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.03  E-value: 3.11e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  377 SYQGYILESAPVGATIsdslnltspLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGItryLTLLQPVDREEQQTY 455
Cdd:cd11304      1 SYEVSVPENAPPGTVV---------LTVSATDPDSGENGEVTYSIVSGNEDGLFSIdPSTGE---ITTAKPLDREEQSSY 68

                           90       100       110
                   ....*....|....*....|....*....|
gi 1237938304  456 TFSITAFDGVQE--SEPVIVNIQVMDANDN 483
Cdd:cd11304     69 TLTVTATDGGGPplSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 821-902 3.27e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.30  E-value: 3.27e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304   821 AKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEafpdQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 898
Cdd:smart00112    2 ATDADSGENgkVTYSILSGNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1237938304   899 DYPP 902
Cdd:smart00112   78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 129-218 2.39e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.64  E-value: 2.39e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  129 SYYATVNELTPVGTTIFTgFSgdngATDIDDGPNGQIEYVIQynpdDPTSNDTFEI-PLmlTGNIVLRKRLNYEDKTRYF 207
Cdd:cd11304      1 SYEVSVPENAPPGTVVLT-VS----ATDPDSGENGEVTYSIV----SGNEDGLFSIdPS--TGEITTAKPLDREEQSSYT 69

                           90
                   ....*....|.
gi 1237938304  208 VIIQANDRAQN 218
Cdd:cd11304     70 LTVTATDGGGP 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1127-1221 2.64e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.64  E-value: 2.64e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304 1127 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPikeGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDY 1206
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90
                   ....*....|....*
gi 1237938304 1207 GKGLSGKADVLVSVV 1221
Cdd:cd11304     79 GPPLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
916-1005 2.76e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.24  E-value: 2.76e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  916 DAVKGTPITTVYAEDADPPglPASRVRYRVddvQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS 995
Cdd:pfam00028    8 NAPVGTEVLTVTATDPDLG--PNGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                           90
                   ....*....|
gi 1237938304  996 SSATVKILVL 1005
Cdd:pfam00028   83 STATVTITVL 92
Cadherin pfam00028
Cadherin domain;
492-584 4.33e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.86  E-value: 4.33e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  492 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 570
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|....
gi 1237938304  571 erRNSICTVYIEVL 584
Cdd:pfam00028   81 --LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 510-591 2.61e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.21  E-value: 2.61e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304   510 TAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPaeRRNSICTVYIEVLPPNN 588
Cdd:smart00112    1 SATDADSGENGKVTYSILSGnDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP--PLSSTATVTITVLDVND 78


                    ...
gi 1237938304   589 QSP 591
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 928-1005 5.07e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.74  E-value: 5.07e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1237938304   928 AEDADPPglPASRVRYRVDDvqfPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL 1005
Cdd:smart00112    2 ATDADSG--ENGKVTYSILS---GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 405-485 7.36e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.28  E-value: 7.36e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304   405 VALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGItryLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDAN 481
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIdPETGE---ITTTKPLDREEQPEYTLTVEATDGGGPplSSTATVTITVLDVN 77


                    ....
gi 1237938304   482 DNTP 485
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 154-218 6.38e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.58  E-value: 6.38e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1237938304   154 ATDIDDGPNGQIEYVIQYNPDDptsnDTFEIpLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 218
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDD----GLFSI-DPETGEITTTKPLDREEQPEYTLTVEATDGGGP 61
Cadherin pfam00028
Cadherin domain;
130-217 7.43e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 7.43e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  130 YYATVNELTPVGTTIFTgfsgdNGATDIDDGPNGQIEYVIQYNPddptSNDTFEI-PlmLTGNIVLRKRLNYEDKTRYFV 208
Cdd:pfam00028    1 YSASVPENAPVGTEVLT-----VTATDPDLGPNGRIFYSILGGG----PGGNFRIdP--DTGDISTTKPLDRESIGEYEL 69


                   ....*....
gi 1237938304  209 IIQANDRAQ 217
Cdd:pfam00028   70 TVEATDSGG 78
Cadherin pfam00028
Cadherin domain;
1131-1220 1.49e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.76  E-value: 1.49e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304 1131 VSEDARMFTSVLRVKATDKDTGNYSVMAYRliippIKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGK 1208
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYS-----ILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|..
gi 1237938304 1209 GLSGKADVLVSV 1220
Cdd:pfam00028   80 PLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 283-371 1.85e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.43  E-value: 1.85e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304   283 QAIDQDRNiqppsDRPGILYSILvgtPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIE 362
Cdd:smart00112    1 SATDADSG-----ENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                    ....*....
gi 1237938304   363 ILDENNQSP 371
Cdd:smart00112   73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
378-477 6.68e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.22  E-value: 6.68e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  378 YQGYILESAPVGatisdslnlTSPLRIVALDKDIEDTKDPElHLFLNDYTS-VFTVTQtgITRYLTLLQPVDREEQQTYT 456
Cdd:pfam00028    1 YSASVPENAPVG---------TEVLTVTATDPDLGPNGRIF-YSILGGGPGgNFRIDP--DTGDISTTKPLDRESIGEYE 68

                           90       100
                   ....*....|....*....|...
gi 1237938304  457 FSITAFDGVQE--SEPVIVNIQV 477
Cdd:pfam00028   69 LTVEATDSGGPplSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1145-1225 1.80e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.65  E-value: 1.80e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  1145 KATDKDTGNYSVMAYRLIIPPikeGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1224
Cdd:smart00112    1 SATDADSGENGKVTYSILSGN---DDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    .
gi 1237938304  1225 D 1225
Cdd:smart00112   78 D 78
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 453-723 1.37e-04

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 47.34  E-value: 1.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  453 QTYTFSITAFDGVQESEPVIVNIQVmdANDNTPTFPEISYDVYVytdmRPGDSV-IQLTAVDADegsNGEITYE-ILVGA 530
Cdd:NF038112  1252 TVLTFQLVVSDGTKTSAPDTVTVLV--RNVNRAPVAVAGAPATV----DERSTVtLDGSGTDAD---GDALTYAwTQTSG 1322

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  531 QGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAerrnsicTVYIEVLPPNnqsppRFPQLMYSLEISEAMRv 609
Cdd:NF038112  1323 PAVTLTGATTATATfTAPEVTADTQLTFTLTVSDGTASATD-------TVTVTVRNVN-----RAPVANAGADQTVDER- 1389

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938304  610 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTL-GKALDRESTDRYILIITAsdgrpDGTSTATVNIVVTDV 688
Cdd:NF038112  1390 STVTLSGSATDPDGDALTYAWTQTAGPTVTLTGADTATASFtAPEVAADTELTFQLTVSA-----DGQASADVTVTVTVR 1464

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 1237938304  689 NDN-APVFDpylPRNLSVVEEEANAFVgQVKATDPD 723
Cdd:NF038112  1465 NVNrAPVAH---AGESITVDEGSTVTL-DASATDPD 1496
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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