NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1241781428|ref|NP_001342167|]
View 

inactive phospholipid phosphatase 7 isoform 2 [Mus musculus]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 256)

type 2 phosphatidic acid phosphatase (PAP2) family protein may be a histidine phosphatase or a vanadium haloperoxidase, and is predicted to be a transmembrane protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PAP2_like super family cl00474
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 97-151 5.41e-25

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


The actual alignment was detected with superfamily member cd03391:

Pssm-ID: 469784 [Multi-domain]  Cd Length: 159  Bit Score: 94.69  E-value: 5.41e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1241781428  97 GVCAGRAASWASARSMVKLIGITGHGIPWIGGTILCLVRSSTLAGQEVLMNLLLA 151
Cdd:cd03391     1 GVCARETSSWGPVRPLVKLLELSGHGIPWLAGTISCLWISSSPAGQEVLVNLLLG 55
 
Name Accession Description Interval E-value
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 97-151 5.41e-25

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 94.69  E-value: 5.41e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1241781428  97 GVCAGRAASWASARSMVKLIGITGHGIPWIGGTILCLVRSSTLAGQEVLMNLLLA 151
Cdd:cd03391     1 GVCARETSSWGPVRPLVKLLELSGHGIPWLAGTISCLWISSSPAGQEVLVNLLLG 55
 
Name Accession Description Interval E-value
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 97-151 5.41e-25

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 94.69  E-value: 5.41e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1241781428  97 GVCAGRAASWASARSMVKLIGITGHGIPWIGGTILCLVRSSTLAGQEVLMNLLLA 151
Cdd:cd03391     1 GVCARETSSWGPVRPLVKLLELSGHGIPWLAGTISCLWISSSPAGQEVLVNLLLG 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH